Abstract: A consumable film adapted to adhere to and dissolve in the oral cavity of a consumer comprising at least one water soluble polymer, at least one antitussive agent and a mucosa-coating effective amount of a mucosa-coating agent.

Abstract: A catamenial device, the device having a topsheet having a body facing surface, wherein the topsheet has a level of hydrophobicity. A lotion composition is applied to at least a portion of at least to the body facing surface of the topsheet, the lotion composition having a level of hydrophobicity equal or greater than that of said topsheet. A backsheet is joined to the topsheet and an absorbent core is disposed between the topsheet and said backsheet.

Abstract: The invention provides wound dressings and methods of their use, especially for the treatment of chronic, non-healing wounds. The wound dressings are composed of a support matrix, such as cotton cellulose, and an active agent associated with the support matrix. The active agent may be a protease inhibitor or a protease sequestrant, in particular an inhibitor or sequestrant of a neutrophil-derived cationic protease such as elastase.

Abstract: A sticking plaster for controlled release of natural human &agr;-interferon for use in viral therapies, in particular anti-herpes therapies, comprises a thin flexible support and a layered adhesive forming a matrix, a therapeutically effective quantity of the interferon being dispersed in said matrix.

Abstract: Compounds of a histone deacetylase inhibitor. The compounds are capable of simultaneously modulating cell cycle-related gene expression and inflammatory cytokine production, and are useful as anti-inflammatory agents in connective tissue disease resulting from altered patterns of immunoregulation. The present invention provides methods of treating, preventing or ameliorating connective tissue diseases, which share common features including inflammation of skin, joints and soft tissues as well as altered patterns of immunoregulation, by administering a therapeutically effective amount of a histone deacetylase inhibitor.

Abstract: The present invention relates to stable quick-release extrudates that contain low-viscosity hydroxypropylcellulose and at least one active ingredient. This invention also relates to a method for preparing said extrudates without the use of solvents as well as to the use of said extrudates in the production of quick-release preparations.

Abstract: The soluble, rubber-containing, coated chewable tablet contains chewable components, syrup components and fat or wax components and optionally fillers. It can be prepared by a process in which pulverulent chewable components are mixed with the molten fat or wax components. The mixture, with the addition of at least one syrup component, then becomes a crumbly material, which is then cooled to below 0° C., then milled to a particle size of not more than 5 mm and, after cooling to below 10° C., compressed to give tablets which are coated in a known manner. The finished product—due to compression of the cooled granules—presumably has a partially granular structure in which the moisture has been initially immobilized by the low temperature. After compression, this moisture becomes mobile as a result of heating (in particular during the coating process) and migrates or diffuses—initially at the surface—into the water-soluble ingredients present.

Abstract: Rapidly dispersing solid dry therapeutic dosage form comprised of a water insoluble compound existing as a nanometer or micrometer particulate solid which is surface stabilized by the presence of at least one phospholipid, the particulate solid being dispersed throughout a bulking matrix. When the dosage form is introduced into an aqueous environment the bulking matrix is substantially completely dissolves within less than 2 minutes thereby releasing the water insoluble particulate solid in an unaggregated and/or unagglomerated state. The matrix is composed of a water insoluble substance or therapeutically useful water insoluble or poorly water soluble compound, a phospholipid and optionally also at least one non-ionic, anionic, cationic, or amphipathic surfactant, together with a matrix or bulking agent and if needed a release agent. The volume weighted mean particle size of the water insoluble particle is 5 micrometers or less.

Abstract: Sucralfate gel in the dry state in porous granular form having a particle-size distribution of between 100 and 1000 &mgr;m, an apparent density of the powder bed of between 0.7 and 0.9 g/ml, a settling index of between 5 and 15%, and a residual humidity of between 5 and 15%, and the corresponding process of preparation, which comprises a treatment with microwaves of a diluted solution of powdered sucralfate gel, with a sucralfate titre of between 20 and 70 wt. %. This solid product may be advantageously used in the preparation of solid pharmaceutical compositions that contain it as single active principle, or else as coating of solid compositions that contain, as active principle, a substance that may cause lesions to the gastric mucosa.

Abstract: An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more delayed release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.

Abstract: Extended release tiagabine formulations that demonstrate fewer side-effects when administered to a patient.

Abstract: The present invention discloses a process for preparing controlled-release preparations which can rapidly release 99% or more of a slightly soluble medicament (which has by itself shows a slow dissolution rate) in the upper part of the small intestine and compositions thereof. The present invention also discloses a process comprising carrying a slightly soluble medicament which has a slow intestinal dissolution rate on aggregates of the spherical microparticles of a multivalent metal alginate, in which each of the secondary particles (i.e., the aggregates) has a specific surface area ranging from 1 to 280 m2/g and compositions thereof.

Abstract: A solid dosage form for oral administration to a patient comprising a core tablet sheathed in an annular body of compressed powder or granular material is provided. A preferred embodiment of the solid dosage form reduces contact of the active ingredient in solid form with the mucosa lining the gastrointestinal tract, which is particularly advantageous for delivering an ulcerative drug. A tool set comprising a columnar punch and a punch assembly comprising an annular punch and core rod, and a tableting process for making the solid dosage form are also provided.

Abstract: The present application relates to an oil-in-water nanoemulsions which comprising an oily phase dispersed in an aqueous phase, the oil globules of which have a mean size of less than 100 nm, characterized in that it comprises at least one amphiphilic lipid chosen from nonionic amphiphilic lipids, anionic amphiphilic lipids and their mixtures and at least one anionic polymer which contains at least one hydrophobic chain and in which the weight ratio of the amount of oily phase to the amount of amphiphilic lipid ranges from 1.2 to 10. The anionic polymer can in particular be an acrylic or methacrylic acid copolymer or a 2-acrylamido-2-methylpropanesulphonic acid copolymer, in particular an acrylic or methacrylic acid terpolymer. The nanoemulsion obtained is transparent and stable on storage. It can constitute a composition for topical use and in particular for cosmetic or dermatological use, a pharmaceutical composition, or an ophthalmological composition.

Abstract: The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regimen can also be provided by the use of an appropriate depot. Furthermore, a composition containing a combination of medicaments is also provided.

Abstract: The specification discloses an alginate composition in which medicaments or cells may be interspersed with aqueous insoluble alginate molecules, so that pellets prepared by this procedure would survive the stomach contents, any enzymatic activity contained therein, as well as the low pH, and gradually dissolve in the intestinal tract behaving as a controlled release system of any specific medicament or cells including, but not limited to, vaccines that are entrapped in the alginate coacervate. Orally administered particles so prepared could be used to eliminate the need for parenteral needle inoculation of various medicaments in man and animals.

Abstract: The present invention relates to a carrier base for the topical delivery of an active agent comprising a high viscosity chitosan biopolymer. The invention further relates to a method of controlling the release of an active agent from a carrier base, comprising as a carrier base a high viscosity chitosan; providing the active agent; and mixing the active agent and the chitosan. Preferably, the carrier base comprises a high viscosity chitosan having a molecular weight of at least about 100,000 Dalton, more preferably at least about 250,000 Dalton and most preferably at least about 300,000 Dalton. In other preferred embodiments the chitosan has a concentration of at least about 2 weight %.

Abstract: The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.

Abstract: Administration of a formulation comprising a antirestenotic compound conjugated to a microparticle carrier is effective to inhibit stenosis formation in a blood vessel. Such stenosis typically results, in the absence of treatment, from trauma to a vessel, such as an incision, excessive pressure, an angioplasty procedure and/or stent implantation. The antirestenotic compound is typically an antiproliferative, immunosuppressive, or antiinflammatory drug, such as rapamycin, tacrolimus, paclitaxel, dexamethasone, or an active analog or derivative, an antisense oligonucleotide, or combinations thereof. The microparticle carrier comprises a suspension of gas-filled microbubbles or biocompatible polymeric microparticles, in a pharmaceutically acceptable liquid vehicle, and is effective to deliver the conjugated therapeutic to the site of vessel injury.

Abstract: Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins.

Abstract: A method for treating cancer patients undergoing chemotherapeutic treatments by administering Product R, a peptide-nucleic acid preparation, is disclosed.

Abstract: A highly safe bone resorption suppressing agents, which can be used as medicines or admixed to food products or feeds, is produced. Milk-derived basic cystatins and/or milk-derived basic cystatin decomposition products prepared from milk are made into bone resorption suppressing agents, or admixed to drinks, food products and feeds.

Abstract: A process for controlling a wide variety of simple celled pests by applications of various formulations using sodium peroxyhydrate as a principal active ingredient. Some forms of the pesticide further include at least one other less reactive material which may be selected from the group consisting of lime (calcium oxide), gypsum, clay calcium nitrate, urea, calcium nitrate tetrahydrate, ammonium nitrate, monocalcium phosphate, dicalcium phosphate, ammonium phosphate, a fertilizer, a form phosphate, and epsom salt. In some embodiments of the invention the pesticide includes a material selected to control the pH at the area of application and thereby constrain the development of microorganisms. The invention also includes the process for controlling microorganisms on turf which comprises applying sodium percarbonate and irrigating the turf. The sodium percarbonate may be utilized in either a solid form or may be in solution.

Abstract: Allergen neutralization compositions for use on inanimate objects having an effective amount of an allergy neutralizing metal ion, and a solvent. The allergen neutralization compositions are sprayable, and preferably contain allergen denaturing compounds such as polyphenol compounds, hydrogen peroxide, salicylic acid, citric acid, lactic acid, glycolic acid, and mixtures of these. The metal ion is selected from ions of zinc, stannous, stannic, magnesium, calcium, manganese, titanium, iron, copper, nickel, and mixtures of these. These allergen neutralization compositions provide excellent efficacy against various allergens, and specifically, the allergens associated with house dust mites and other common allergens such as cat dander, pollen and the like. Moreover, these compositions do not stain common household surfaces.

Abstract: Methods of inducing apoptosis and modulating metalloproteinases, particularly with metal-containing compounds, are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

Abstract: Disclosed are a multipurpose, high-functional, alkaline solution composition, preparation therefor and use thereof as a nonspecific immunostimulator. The composition comprises 1-25 parts by weight of borax (Na2B4O7.10H2O), 10−5-10−4 parts by weight of sodium thiosulfate (Na2S2O3.5H2O), 30-150 parts by weight of potassium carbonate, 30-200 parts by weight of refined sugar (C12H22O11), and 100-200 parts by weight of water, based on 100 parts by weight of sodium metasilicate (Na2SiO3.5H2O). In addition to bringing about an improvement in disease resistance, weight gain rate, crop yield, crop quality, harvest time, the composition shows nonspecific immunostimulating activities, including antibody production and immune enhancement, by activating immune cells, thereby maximizing vaccination effects on malignant viral diseases.

Abstract: Fungicidal compositions comprising an acceptable carrier and/or surface active agent and synergistically effective amounts of

Abstract: Multivitamin/Multimineral supplements are provided for supplementing iron and desirable nutrients in the diet of mammals. The supplements include an iron-amino acid chelate, a form of iron more bioavailable than traditional iron salts. The supplements may further include a pharmaceutically accepted salt form of iron as well as other nutritional vitamins and minerals. The supplements are useful for providing iron for pregnant and lactating females as well as for persons suffering from anemia.

Abstract: The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon administration to the eye. The present invention also discloses methods of topical ophthalmic administration of the compositions to the eye.

Abstract: The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The indicator aspect provides ease of visually detecting the material on the animal skin and can indicate efficacy of the material. The compositions of the invention are made by combining an aqueous liquid composition containing the visual indicator combined with the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite.

Abstract: A novel formulation is provided that serves to synergistically inhibit the generation of free radicals and oxidative stress in warm blooded animals. The formulation comprises an effective amount of a first component of a carotenoid species, and, as a second component, a tocotrienol species and derivatives thereof, and provides for synergistic anti-oxidant activity.

Abstract: The present invention consists of and all natural deodorant/antiperspirant which contains olive oil, almond oil, wheat germ oil as gentle soothing emolients, salvia officianalis and cupressus semperiens as natural astringents, lavendula angustifolio and citrus aurantium as natural, mild antiseptic compounds. Beeswax or hydrogenated castor oil may be added as a gentle thickening agent where the inventive formulation is to be used in cream or solid form. In such a manner, skin irritation, swelling, occlusions and inflamations are prevented. 1 Preferred Permissible Range Ingredient Embodiment (volume % given) 100% Olive Oil 29.2% 27.2-31.2% 100% Almond Oil 43.8% 41.8-45.8% 100% Wheat Germ Oil 21.9% 19.9-23.9% Beeswax 2.9% 2.7-3.1% Salvia Officinalis 0.73% 0.71-0.75% Lavendula Angustifolio 0.58% 0.56-0.60% Citrus Aurantium 0.44% 0.42-0.46% Cupressus Semperiens 0.44% 0.42-0.

Abstract: Substances having antiviral activity against one or more human disease-causing viruses are disclosed. These antiviral substances are obtained from the cuticular and extracuticular layers of plants. Pharmaceutical and nutraceutical formulations comprising the antiviral substances are also disclosed, as are methods of using such formulations to treat viral diseases.

Abstract: The invention relates to compositions and methods for preventing, treating, or managing sleeplessness, restlessness, weight gain including weight gain due to stress or lack of sleep, or all three comprising the administration of a prophylactically and therapeutically effective amount of Magnoliaceae plant or extracts thereof to a mammal in need of such therapy. Preferably the mammal is human and the compositions have comprise at least two compounds selected from magnolol, honokiol, and magnoflorine. Alternatively, the compositions may also comprise about 2% honokiol by weight of the composition.

Abstract: An active substance is extracted from an herbal composition which comprises: Centaurii umbellatum, Gentianaceae (centaury plant), Teraxacum officinale, Asteraceae (dandelion root), Juniperi communis L, Cupresaceae (juniper berry), Urticae dioica L, Urticeae (nettle plant), Urticae dioica L, Urticaceae (nettle root), Cichorium intybus L, Cichoriaceae (chicory root), Morus nigra L, Moraceae, (mulberry leaf), Achilleae millefolium L, Asteraceae (yarrow flower), Vaccinium myrtillus L, Ericaceae (bilberry leaf), Phaseolus vulgaris L, Fabaceae (bean pods), Valeriana officinalis L, Valerlanaceae (Valerian root). The active substance is used in the manufacture of pharmaceutical compositions used in connection with control of diabetes mellitus type II.

Abstract: Disclosed are a natural invigorating tea and a method for preparing the same. The natural invigorating tea may be in the form of powder, liquid, or granules and is made of parasitic herb, and alder and/or schizandrae fructus, optionally supplemented with torilis fructus and/or polygalae japonica herba. Taking of the tea at least twice a day, morning and evening, invigorates human body.

Abstract: A solid dosage form is provided which includes an active agent and silicified microcrystalline cellulose, the dosage form formed by a) combining a wetted active agent with dry silicified microcrystalline cellulose in a dryer to form agglomerated particles; and b) incorporating the agglomerated particles into the solid dosage form. In certain preferred embodiments, step b comprises combining said silicified microcrystalline cellulose, said active agent, and colloidal silicon dioxide in a dryer. Preferably, the dryer is a spray dryer, and, in certain embodiments, the active agent may be an herbal extract.

Abstract: The present invention relates to compositions and absorbent articles including compositions for protecting the skin barrier. The compositions can be applied to the bodyfacing surfaces of absorbent articles so that the compositions come into contact with the skin. The compositions of the invention provide several benefits including prevention and alleviation of skin irritations associated with the use of absorbent articles. The compositions can include hydrophilic and non-aqueous components as well as extracted botanical actives.

Abstract: Biologically active extracts of celery seed are produced by controlled ethanolic extraction, distillation and drying, and further processing by supercritical fluid extractions (SFE), and may be further fractionated by column fractionation, distillation, LiAlH reduction and the like. These extracts possess activity for the treatment and prevention of acute and chronic pain, inflammation and gastrointestinal irritation.

Abstract: The present invention relates to cacao extract including dietary fiber, more specifically cacao extract including dietary fiber useful for the treatment of diabetes obtained as a residue of solvent extraction of the cacao bean husk (CBH) conventionally wasted after using only cacao bean (CB), which has the following characteristics:

Abstract: A method of inducing weight loss and promoting homeostasis in an individual relies on olfactory and gustatory reaction of the individual to a wide variety of offered groups of food items. The individual is encouraged to select one particular type of a food item, for instance one type of fruit, based on positive alliesthesial response, and consume this type of food item until negative alliesthesia is detected. Once alliesthesia is reached, the individual is encouraged to stop eating. The next meal, removed by several hours from the first meal, relies on similar concepts.

Abstract: Methods of prophylaxis or treatment of a disease state initiated by or characterized by platelet aggregation, that employ a fruit extract or active fraction thereof, are disclosed. In one embodiment, the fruit extract or active fraction thereof, is obtained from the fruit of plants of the families Solanaceae, Rutaceae, Cucurbitaceae, Rosaceae, Musaceae, Anacardiaceae, Bromeliaceae, Vitaceae, Arecaceae, Ericaceae and Lauraceae. Pharmaceutical compositions comprising a fruit extract or active fraction thereof having platelet aggregation inhibitory activity are also disclosed.

Abstract: An air injection valve assembly includes an actuator and a valve section. The valve section generally includes a valve body and a valve stem movable therein. The valve stem includes a valve head which mates with a valve seat when in the closed position. A valve head facing surface of the valve head is manufactured to be completely flush with a valve seat facing surface of the valve seat. The facing surfaces are preferably contoured to exactly match the interior contour of the mold cavity. When in the closed position the valve head blends into the mold cavity and thus minimizes the chance of a blemish being formed on the molded article.

Abstract: A process for injection molding a composite of rigid thermoplastic and soft thermoplastic, the soft thermoplastic including a cavity established with pressurized assist gas or an assist liquid. The process includes the steps of: injecting a hard molten thermoplastic into a first mold chamber; injecting a soft molten thermoplastic into a second mold chamber; establishing communication between the first chamber and the second chamber so that the rigid thermoplastic and soft thermoplastic integrally bond; and injecting an assist fluid into the soft thermoplastic to form a cavity. In a preferred embodiment, the formed composite is an automotive cowl where the rigid thermoplastic forms the rigid body portion of the cowl and the integrally bonded soft thermoplastic forms a compressible bulb seal.

Abstract: A part-forming machine having an in-mold integrated vision system and method therefor for verifying the presence, absence and quality of molded parts therein. The image of the mold and/or part is acquired at a substantially parallel angle relative to the image-capturing source thereby allowing the imaging of the mold while the mold is opening thus increasing the resolution, speed and accuracy of part-forming machine imaging systems.

Abstract: An improved melt distribution system and method is provided for a multi-level stack mold having three or more moving platens. The injection machine communicates with a bifurcated sprue bar for providing pressurized melt through the first moving platen to a central distribution manifold in the second moving platen. From the central distribution manifold, the flow of pressurized melt is distributed to the first and third platens for transfer to a plurality of mold cavities.

Abstract: In a method and apparatus for cutting expanded graphite sheet material, at least one cutting tool is urged against the sheet(s). The cutting tool has at least one ridge extending therefrom that includes a substantially tapered cross-section having sloping sides and an edge surface. At least a portion of the sheet material is displaced as the ridge is urged against the sheet. A region of the sheet material in contact with the ridge is compressed so that the density of the region reaches or exceeds the breaking density of the sheet.

Abstract: Novel thermoplastic pipes which can withstand extremely high internally generated and/or applied pressures for utilization within, primarily, high pressure underground liquid and gas transport systems are provided. Such pipes are improvements over standard metal (i.e., steel, lead, and the like) pipes due to construction costs, shipping costs, implementation costs (particularly underground), modulus strength allowances to compensate for underground movements (i.e., earthquakes and tremors), non-rusting characteristics, and ease in manufacture. Such pipes are preferably reinforced with specific fabric articles which permit a lower thickness of plastic to be utilized than is generally required to withstand high pressure situations. A simplified, potentially on-site production method for producing more uniform, better-performing pipes as well as a specific molding dorn for such a purpose are also contemplated within this invention.

Abstract: A process for the production of a shaped article of a consumable product in which a composition is extruded through a die comprising at least one orifice characterised in that the cross-sectional area for flow through the said at least one orifice is varied in a continuous fashion during at least part of the time said extrusion is occurring, whereby an extrudate is obtained whose cross-sectional area varies along at least a part of its length. Apparatus suitable for carrying out the process are also described.

Abstract: Improved mold manifold and hot runner nozzle using thin film elements include at least one active or passive thin film element disposed along a melt channel between the manifold inlet and the hot runner nozzle. Preferably, the thin film element may comprise a thin film heater in direct contact with the molten resin and position to aid in the heat and flow management of the resin within the melt channel. Thin film temperature sensors, pressure sensors, and leak detectors may also be provided in the vicinity of the melt channel to enhance process control in the injection molding machine.