Abstract: Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by wet granulation tablet formulation. These pharmaceutical compositions are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease. These compositions are prepared without the addition of binder; instead, the drug itself acts as a binder.

Abstract: The invention describes a tablet with two end faces and a circumferential face, in which the mutually opposite end faces of the tablet a) overall are nonplanar and are arranged at least approximately parallel to one another, and b) are each provided with a score on the top and bottom sides, the scores lying in the center of the tablet parallel to and above one another.

Abstract: The present invention relates to a controlled release drug delivery system comprising a drug which is susceptible to enzymatic degradation by enzymes present in the intestinal tract; and a polymeric matrix which undergoes erosion in the gastrointestinal tract comprising a hydrogel-forming polymer selected from the group consisting of (a) polymers which are themselves capable of enhancing absorption of said drug across the intestinal mucosal tissues and of inbihiting degradation of said drug by intestinal enzymes; and (b) polymers which are not themselves capable of enhancing absorption of said drug across the intestinal mucosal tissues and of inhibiting degradation of said drug by intestinal enzymes; wherein when the matrix comprises a polymer belonging to group (b) the delivery system further comprises an agent which enhances absorption of said drug across the intestinal mucosal tissues and/or an agent which inhibits degradation of said drug by intestinal enzymes and when the matrix comprises a polymer belon

Abstract: Disclosed is a beadlet comprising (i) a hydrophobic long chain fatty acid or ester material; (ii) a surfactant; and (iii) a therapeutic agent which in admixture form a solid solution at room temperature. The hydrophobic material preferably has a melting point of about 40 to about 100° C., and is most preferably glyceryl behenate. The surfactant is preferably a polyglycolyzed glyceride, polyoxyethylene sorbate, ethylene or propylene block copolymer or combinations thereof, and is most preferably polyoxyethylene 20 sorbitan monolaurate.

Abstract: The present invention discloses an efficient preparation method of spherical fine particles containing a drug for an easily-swallowed, controlled-release preparation comprising the production of drug-containing spherical fine particles (mean particle size: 60-200 &mgr;m) by adding a binder solution to a mixture containing an excipient powder having the property of retaining solvent (and preferably having a mean length of the long axis of 40 &mgr;m or less) and a drug powder (preferably having a mean length of the long axis of 50 &mgr;m or less), followed by high-speed mixing granulation.

Abstract: The present invention discloses sustained release particles having a mean particle size of 300 &mgr;m, or less, comprising a drug-containing core substance coated with a mixed coating of a hydrophobic organic compound-water-insoluble polymer, which prevents sticking during compression molding when producing oral sustained release tablets, a preparation method of those sustained release particles, and a preparation method of tablets using those sustained release particles.

Abstract: A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are med to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 &mgr;g and have no covalent chemical cross-linking.

Abstract: Novel emulsion compositions which improve the rate and/or extent of absorption of drugs are disclosed. The novel emulsion compositions of the present invention include drug-containing emulsions adsorbed onto solid particles which may be further formulated into solid dosage forms, methods of preparing such emulsion compositions and their uses thereof. The emulsion compositions and their dosage forms improve the drug-load and the bioavailability of a wide range of drugs including drugs that are known or suspected of having poor bioavailability by the utilization of several different mechanisms.

Abstract: Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications.

Abstract: The invention relates to the use of one or more noble metals selected from silver, gold, platinum, and palladium but most preferably silver, in a nanocrystalline form, for the treatment of a hyperproliferative skin disorder or disease such as psoriasis. Among the noble metals, silver is preferred for such treatment. The nanocrystalline noble metal of choice may be used in the form of a nanocrystalline coating of one or more noble metals, a nanocrystalline powder of one or more noble metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more noble metals.

Abstract: Novel synergistic fungicidal compositions used for protecting seeds, plants and other vegetative material against fungi contain a mixture of one or more compounds selected from group A and one or more compounds selected from group B. Compounds from group A are selected from &bgr;-Amino butyric acid and its N-benzoyl-octyl ester derivatives. Compounds from group B are selected from the group of fosetyl aluminum, dimethomorph, a mixture of folpet and ofurace (45:5), folpet, fencaramid (Bayer SZX), mancozeb, cymoxanil, methalaxyl, the single optical isomer of metalaxyl, a mixture of cymoxanil and mancozeb (4:1), copper sulfate, copper hydroxide, copper sulfate hydrate, azoxystrobin, and acibenzolar-s-methyl.

Abstract: A gel formulation is combined with a bactericidal concentrate which is a liquid mixture of about 1000 parts by volume of ultra pure water having an electrical resistance of 16-26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 mho with about 1.2 to 3 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943. The bactericidal liquid concentrate in the amount of 3.5 to 12 ml in one liter of gel formulation is applied directly to a skin surface area having a burn or other dermal lesion to protect the area from bacterial contamination.

Abstract: Damaged or imperfect hair shafts are treated by: (a) hydrating hair shafts to open flaps of the cuticles layer, (b) applying to the hair shafts amino acids or peptides effective to nourish hair, and (c) compressing the hair shafts under heat by sandwiching the hair shafts between heated plates to cause the amino acids or peptides to penetrate through the cuticle layer and close the openings between the flaps. The penetrated amino acids or peptides nourish the cortex. The hair shafts may be subjected to hair styling treatment.

Abstract: This invention relates to a pharmaceutical composition containing herbal ingredients for the treatment of diabetes mellitus and more particularly, to the antidiabetic composition comprising 1) 15 herbal ingredients (i.e., Shinseng Radix, Coptis Rhizoma, Ligustri Fructus Semen, Salix spp. Cortex, Rhei coreani Rhizoma, Anemarrhena Rhizoma, Salviae Radix, Scrophulariae Radix, Lycii Cortex Radicis, Reynoutriae Radix, Platycodi Radix, Astragali Radix, Puerariae Radix, Atractylis Rhizoma, and Morus alba Radix Cortex), 2) vitamins such as B1 and B6, and 3) zinc, manganese, chromium, germanium as inorganic materials. The antidiabetic herbal composition of this invention for the prevention and treatment of diabetes serves to lower the glucose level in diabetic patients and prevent the destruction of beta-cell in the pancreas, while increasing insulin secretion based on the mechanism of recovering the function of damaged beta-cell.

Abstract: The present invention includes a method for producing a chewing gum with a modified release sweetener selected from the group of N-substituted derivatives of aspartame, particularly neotame, as well as the chewing gum so produced. The modified release neotame or other N-substituted derivative of aspartame sweetener is obtained by physically modifying the sweetener properties by coating and drying. Neotame or another N-substituted derivative of aspartame sweetener is coated by encapsulation, partially coated by agglomeration, entrapped by absorption or extrusion, or treated by multiple steps of encapsulation, agglomeration, absorption, or extrusion. The coated sweetener is then co-dried and particle sized to produce a release-modified high-intensity sweetener. When incorporated into the chewing gum, these particles are adapted to enhance the shelf stability of the sweetener and/or produce a modified release when the gum is chewed.

Abstract: Food products can include dried microorganisms as a biocontrol agent. The dried cultures resist inactivation during pasteurization of the food product. The microorganisms are selected to be nontoxic and to inhibit growth of pathogenic microorganisms. For example, the biocontrol microorganisms can produce acid to lower the pH of the product thereby inhibiting the growth of pathogens.

Abstract: The invention is a beverage device having a beverage pack, such as a bag containing substances to be added to flavor a liquid and a shield. The shield is connected to the pack and encapsulates the pack in the bottom of a cup. The shield has an open orientation which allows beverage pack steeping and a closed orientation. The shield can be made from two portions. A stick can be used to push the shield to the bottom of the cup and orient the shield in its closed orientation.

Abstract: A beverage infusion device comprises a handle and a support member extending from the handle having a pair of flat legs spaced apart by a predetermined width. Attached to each side of the flat legs is a flexible porous member, for example, a pouch of filter material having an unfolded width greater than the width of the support legs. Each porous member contains an infusible beverage preparation and is supported by the support legs in a folded position wherein, upon immersion of the porous members in a liquid, the porous members expand and become spaced to facilitate infusion of a beverage preparation therein into the liquid. In the folded position, the porous members may have a plurality of folds across its width, for example, folds adjacent the first and second ends and an unfolded portion therebetween. The first and second ends of the porous member are preferably heat bonded to the support legs.

Abstract: Potato products that retain shred integrity and that are sufficiently thin to fit into a standard toaster have been produced. In some embodiments, the potato products contain a filling. The potato products contain a network of shredded potatoes that enables the potato products to retain structural integrity during production and further manipulation of the product. Extrusion and sheeting methods are used to obtain potato products that retain the desirable shred integrity. A method and apparatus is provided for simultaneously cutting and crimping individual food items from a filled extruded or sheeted product.

Abstract: A method and apparatus for distributing the residual flavor from herbs and aromatics into the interior of meat for seasoning prior to and during cooking. The apparatus comprises a reservoir for holding the aromatics in the form of a tapered, split, meat-piercing rod inserted into the interior of meat containing a predetermined amount of aromatics and or herbs. After reaching the desired depth, the devise remains in the meat during the cooking or marinating process. The devise is removed prior to the consumption of the meat leaving behind the residual flavor from the contents of the devise.

Abstract: There is provided a process for pasteurizing in shell chicken eggs (2) carried in stacks (1) by placing the eggs in a heated fluid bath (4) having a temperature of between about 128 to 145 degrees F., allowing the eggs to dwell in the heated fluid bath until there is a log reduction of at least 4.6 of any Salmonella bacteria within the eggs, removing the eggs from the heated liquid bath and into a gaseous atmosphere (26), and contacting the eggs with an antibacterial fluid (28) containing an antibacterial agent. Preferably, the eggs are thereafter contacted with a sealant such as wax. In the gaseous atmosphere the eggs further pasteurize to at least a 5 logs reduction of the bacteria by way of residual heat in the eggs. During cooling in the gaseous atmosphere, the eggs suck the antibacterial fluid into the eggs between the inside of the shells and the membranes and provide antibacterial barriers in the eggs.

Abstract: A manipulating apparatus (10) receives a plurality of previously frozen pieces of pH modified foodstuffs or workpieces (23) and physically manipulates or stresses the workpieces while they remain in a frozen state. The physical manipulation causes relative movement between various points within the volume of the workpieces (23) and kills microbes within the foodstuff. One preferred pH modifying arrangement includes a supply of NH3 gas (11) and a pump (9) for placing the comminuted foodstuffs to be processed and the NH3 gas together under an operating pressure for a period of time sufficient to increase the pH of the foodstuffs.

Abstract: The invention relates to a process for the crossflow micro-filtration of beer. In order to prevent the clogging of the membrane of the filter module by components of the non-clarified beer which are to be filtered out and settle in the form of a covering, the filtration is interrupted at intervals. In a subsequent brief pause the covering on the membrane is chemically and partially dissolved with a caustic solution whereafter the covering is subsequently removed by backwashing of the membrane with water. In order to further improve the filtration, the transmembrane pressure (p) is regulated during the filtration phase according to a substantially periodic time function, and the crossflow velocity (v) of the beer over the membrane is increased substantially continuously.

Abstract: Canned pet food products as well as methods of manufacturing or producing same are provided. The pet food comprises a base layer including solid food pieces in a gravy that has a conical recess formed in its upper surface. An upper layer comprising substantially solid foodstuff that can support the base layer when the food product is inverted fills the conical recess.

Abstract: Compositions for generating a cooked flavor in a foodstuff, comprising specified flavor precursors that react on heating to generate the flavor and maintain a reactive association after inclusion in the foodstuff. The compositions may include combination of a sulphur source, e.g. hydrogen sulphide, methane thiol, a sulfur-containing amino acid, thiamine, cystine, sodium sulphide, ammonium sulphide, ammonium polysulphide, onions, garlic, shallots, eggs, methionine, and mixtures thereof, and at least one reductone, e.g. a furanone, a ketone, a pyrone, an aldehyde, a carbonyl compound, isomaltol, maltol, pyruvaldehyde, hydroxyacetone, 3-deoxyglucosone, 5-hydroxy-5,6-dihydromaltol, 2,3-butanedione, 3-hydroxy-2-butanone, a process flavor, cooked vegetable concentrates, soy sauce, and mixtures thereof.

Abstract: The present invention relates to a corn syrup composition that can be used in many applications in place of butter, margarine or other spreadable products. The corn syrup composition is lower in fat than conventional spreads, provides a pleasing flavor and is compatible with many flavoring and coloring options. The formulation combines a corn syrup component, such as high fructose corn syrup, with a fat/oil component, such as butter or other fats. The formulation may also include other flavorings, preservatives, emulsifiers and anti-oxidant ingredients. The formulation may be utilized in any food application but is preferably utilized as a coating, spread or as a cooking or baking ingredient.

Abstract: The invention relates to a method for providing a proteinaceous coating on a medical implant, comprising the steps of: submersing the implant in a first aqueous solution comprising a protein and magnesium, calcium and phosphate ions through which a gaseous weak acid is passed; degassing the solution; allowing a coating to precipitate onto the implant; submersing the coated implant in a second solution to redissolve the magnesium, calcium and phosphate ions and to obtain the proteinaceous coating.

Abstract: The present invention provides a method for manufacturing a carbon nanotube field emission display. The method comprises the steps of providing a substrate, screen printing a first conducting layer on the substrate, sintering the first conducting layer, screen printing an isolation layer on the first conducting layer and a second conducting layer on the isolation layer, etching the second conducting layer and the isolation layer, whereby a cavity exposing the first conducting layer is formed, sintering the second conducting layer and the isolation layer, and forming a carbon nanotube layer on the first conducting layer in the cavity.

Abstract: Printed wiring boards improved in the drilling processability and insulation properties are produced either by treating the surfaces of base materials or inorganic fillers with silicone oligomers having specified structures, particularly, a three-dimensionally crosslinked silicone oligomer, or by using resin varnish prepared by compounding such a silicone oligomer with a resin varnish for impregnation of the base materials, or by dipping the inorganic fillers in a solution of such a silicone oligomer for surface treatment and then directly compounding resin materials with the solution.

Abstract: A photo curable resin composition, which comprises (A) an acid-modified, vinyl group-containing epoxy resin, (B) an elastomer, (C) a photopolymerization initiator, (D) a diluent and (E) a curing agent, can give a high performance cured film having distinguished heat resistance, humidity-heat resistance, adhesibility, mechanical characteristics and electrical characteristics, and a photosensitive element, which comprises a support and a layer of the photo curable resin composition laid on the support, has distinguished heat resistance, humidity-heat resistance, adhesibility, mechanical characteristics and electrical characteristics.

Abstract: This invention provides a composite having a hydrophilic film made of amorphous titanium oxide. A film is deposited on a substrate made of, for example, glass or synthetic resin. The film is composed of amorphous titanium oxide partially having structures in which a network of Ti—O—Ti bond is broken to give Ti—OH bond terminals.

Abstract: A method for fabricating a semiconductor device is provided. The method includes the steps of: forming an insulating layer having an opening region on a semiconductor substrate; forming a first ruthenium layer on the insulating layer and the opening region by sputtering at a first pressure; forming a second ruthenium layer on the first ruthenium layer by first chemical vapor deposition (CVD) at a first flow rate of oxygen gas and at a second pressure, wherein the second pressure is greater than the first pressure; and forming a third ruthenium layer on the second ruthenium layer by second CVD at a second flow rate of oxygen gas and at a third pressure, wherein the third pressure is greater than the first pressure.

Abstract: The instant invention relates to liquid crystal media comprising a component A, comprising one or more compounds of formula I and a component B, comprising one or more compounds of formula II wherein the parameters are as defined in the text and to liquid crystal displays comprising these media, in particular to TN AMD displays.

Abstract: Alignment layers for use in liquid crystal devices comprising photoactive pentaerythritol derivatives. 1,2,3,4-trakiskis(8-[2-oxo-2H-1-benzopyran-7-yloxy]octanoyloxy)pentaerythritol is but one example.

Abstract: This invention relates to an imaging member comprising an image layer and a paper base comprising a mixture of vegetable fibers and wood fibers wherein said vegetable fibers comprise between 5 and 25 percent by weight of said paper base.

Abstract: An imageable media is disclosed. An imageable media in accordance with the present invention comprises a substrate having a first surface and a porous layer overlaying the first surface of the substrate. In a preferred embodiment, for pigmented inks, a plurality of ink retaining silica particles are disposed within the porous layer. After inkjet imaging with pigmented ink, the porous layer may be fused to create a durable, tamper and scuff resistant, waterproof graphic without a laminate. In another preferred embodiment for dye based inks, a plurality of zeolite particles and a plurality of cross-linked polyvinylpyrrolidone particles are disposed within the porous layer. The porous layer may be imbibed with an ink retention coating for dye based inks. Imageable media made with this invention has utility for commercial graphics, labels and ID cards.

Abstract: A method for reducing the migration of aldehyde compounds present in packaging material the interior of a package formed by said packaging material, said method comprising: (a) selecting an initial packaging sheet stock used for forming a package having an interior in which an aldehyde sensitive product can be contained, wherein said initial packaging sheet stock has a first surface that forms the interior wall of said formed package, wherein said initial packaging sheet stock has a second surface that forms the exterior wall of said formed package, and wherein said initial packaging sheet stock contains one or more aldehyde compounds that are capable of migrating from said initial packaging sheet stock to said package interior or exterior; (b) preparing an amine-containing composition comprising an amine that chemically reacts with said aldehyde compounds to form a substantially non-migrating compound; and (c) applying said amine-containing composition onto said first surface of said initial packaging sheet

Abstract: The present invention provides a method for producing a packaging laminate having excellent gas barrier properties. The method involves applying a solution or dispersion of starch or starch derivative to a surface of a substrate of paper or paperboard, and applying a layer of plastic to said starch or starch derivative so as to modify the properties of same such that the starch or starch derivative provides a gas barrier property.

Abstract: A method of lining a surface of a substrate comprises providing a reactive mixture which comprises (1) a resin containing active hydrogens; (2) a polycarbodiimide; and (3) an organic diluent; reacting the resin containing active hydrogens and the polycarbodiimide to chemically bind the resin and the polycarbodiimide; applying the chemically bound resin and polycarbodiimide to the surface of the substrate; and curing the chemically bound resin and polycarbodiimide in the presence of an initiator to form a cured resin material which lines the surface of the substrate.

Abstract: The present invention relates to membranes including an urethane including a polyester polyol, wherein the membrane has a gas transmission rate of 15.0 or less for nitrogen gas wherein the membrane has an average thickness of approximately 20.0 mils. Under certain embodiments, the membranes include blends of one or more polyester polyol based thermoplastic urethanes and one or more barrier materials. The membranes can be employed in a variety of applications and can be used as either monolayers or multi-layered laminates.

Abstract: Using a balanced flow path, multiple layers of extruded plastic are supplied to a chamber having independently rotating surfaces. Said rotating surfaces apply a shear force to at least the inner and outer layers of said extruded plastic to orient said materials in said layers in different helical patterns, thereby forming a multi-layer tubular product in which at least inner and outer layers have different helical patterns to strengthen the product.

Abstract: A three-layer microwaveable, plastic wrap having a core layer between a cling layer and a release layer is disclosed, along with a method for making the plastic wrap. The cling layer comprises a base resin and an effective amount of a tackifier to provide sufficient cling to different surfaces such as, for example, glass, plastic, ceramic, stainless steel laminated cardboard, and aluminum. The release layer includes an effective amount of an anti-blocking agent to facilitate dispensing of the wrap from a dispensing roll.

Abstract: A device, used for holding and displaying items such as photographs, certificates, compact discs and the like, includes a coversheet having an outward side and an inward side and an edge. A foam sheet material has front and back sides with the front side being connected with respect to the coversheet such that the device includes an entry portion to a pocket for holding the item. The back side of such foam clings to a display surface in a removable and replaceable manner. A backing material may be positioned between the foam sheet material and the coversheet.

Abstract: An adhesive tape construction is removable from one or more objects to which it is adhered and which is reusably separable within its construction so that an object can be separated from another and subsequently reconnected with one another. The adhesive tape construction can be used to bond the other opposed surfaces of objects, including rigid objects such as a picture frame to a wall, where no portion of the adhesive tape construction projects from between the objects, and which subsequently affords easy separation of the objects without damage to either of them. More specifically, the adhesive tape construction includes a stretch release adhesive tape structure combined with a reusable connector surface.

Abstract: A joint apparatus for joining two objects together with end faces in face-to-face engagement includes first and second flat plates for attachment to faces of the respective objects adjacent the end face. Each plate has a first side edge for facing the first side edge of the other plate when secured to the respective object, and the first side edges each have at least one tongue and recess positioned for alignment with the recess and tongue of the other plate, respectively. The plates are positioned on the respective objects such that the tongues project out from the end face of the object and engage in the recess of the other plate when the end faces are abutted, in a zipper-like fashion. The plates may be temporarily clamped together while the tongues are secured to the face of the opposing object, thereby forming the joint.

Abstract: An optical recording medium is provided which comprises: a substrate including concentrically or spirally formed grooves each having a V-shaped cross section; a first dielectric layer formed on the substrate; a phase-change recording layer formed on the first dielectric layer; a second dielectric layer formed on the phase-change recording layer; and a metallic reflecting layer formed on the second dielectric layer. In particular, the optical recording medium is so formed that an objective lens having an aperture number of 0.55-0.70 can be used and a laser beam having a wavelength of 600-700 nm and passing through the objective lens is passed through the substrate and then converged on the recording layer, thereby recording or reproducing information on the recording layer in areas corresponding to the grooves.

Abstract: The purpose is to obtain efficiently, from a large piece of flat optical material, flat optical elements that allow for miniaturization of optical devices because they are octagonal, and that can be fixed securely in the inner opening of permanent magnets by brazing. Rounded openings 11, 12 . . . that are circular or elliptical in shape are made at intersections P1, P2 . . . of the cut lines C1, C2 . . . at which flat optical material 10 is cut vertically and horizontally; the flat optical material 10 in which the openings 11, 12 . . . have been made is cut vertically and horizontally; and a number of flat optical elements, each with a nearly octagonal outline with sides that are alternately four straight lines and curves, are obtained.

Abstract: A substrate having flocked fibers of superabsorbent polymer thereon is provided. The substrate may be one of a variety of materials, such as nonwoven materials, polymer films, apertured films, absorbent layers, netting, woven fabrics, foams, reticulated films and the like.

Abstract: A multilayer sheet structure (10) comprises a front sheet (11), a net-like backing sheet (12), and sewing threads (14) for partially joining the front sheet with the backing sheet so as to form bag portions (13) between the front and backing sheets. Paddings (15) such as cotton, wool or the like can be stuffed through net clearances of the backing sheet into bag portions surrounded with sewing threads to form bulges (11b) at desired locations on the front surface of the front sheet. Thus, a quilted multilayer sheet structure (17) having bulges on the front surface thereof can be easily produced.

Abstract: A system and method of bonding is disclosed which is suitable for providing a strong interlocking adhesive bond between two surfaces. At least one bonding surface is provided with multiple layers of spherical shaped protrusions. The multilayer spherical bonding surface is formed from the substrate and therefore is continuous. Many methods may be employed to form this surface, including the lost wax casting process. Such bonding surfaces provide good interlocking properties for bonding agents such as epoxy resins and ceramics. In addition, the uniform curvature of the spherical particles themselves reduces points of stress thereby substantially reducing or even eliminating the formation of stress fractures.