Abstract: The present invention provides methods and compositions involving resorbable hemostatic agents that have the essential absence of microfibrillar collagen. Resorbable hemostatic agents of the present invention comprise polyethylene glycol, which controls bleeding in tissue and does not delay or interfere with healing. The resorbable hemostatic agents of the present invention are biodegradable and biocompatible agents that effectively control bleeding in bone and other tissue without interfering with the subsequent healing of the tissue.

Abstract: The present invention is directed to ion triggerable, water-dispersible cationic polymers. The present invention is also directed to a method of making ion triggerable, water-dispersible cationic polymers and their applicability as binder compositions. The present invention is further directed to fiber-containing fabrics and webs comprising ion triggerable, water-dispersible binder compositions and their applicability in water-dispersible personal care products, such as wet wipes.

Abstract: A protective glove includes a coating of dehydrated material on its inside surface. The dehydrated material, in contact with perspiration from a hand wearing the glove, soothes the hand. Some methods of placing the coating onto the inside surface of the glove include spraying or dipping with a solution that includes Aloe Vera.

Abstract: Proteinaceous tissue defect dressings and methods for their use.

Abstract: The present invention relates to a method for reducing triglyceride levels in a patient and effecting hormone replacement therapy comprising continuously and transdermally administering an essentially constant therapeutically effective amount of a composition comprising an estradiol (17&bgr;-estradiol) and a progestin (levonorgestrel (LNG)) in a pharmaceutically acceptable carrier.

Abstract: An article of manufacture for use in removing corns and callus from a person comprising a first strip comprising a backing member and first and second medicated patches having salicylic acid releaseably affixed to the backing member. Each of the first and second mediated patches comprise first and second outside edges and an inside edge. The first and second medicated patches are nested and adjoined along the inside edges of said first and second medicated patches, respectively.

Abstract: UEA-1 Mimetics, pharmaceutical formulations comprising them, and their uses as targeting agents for therapeutic and diagnostic purposes.

Abstract: Particles larger than 7 microns in diameter and containing a therapeutic material are described. Such particles are sufficiently large to lodge in tissue or a blood vessel and can be made to rapidly degrade therein before creating infarcts. Rapid degradation of liposomes containing a therapeutic agent can be achieved by either preparing the liposome in a high salt solution or incorporating in the liposome a component which is stable at or below room temperature, but which becomes unstable at 35° C. or higher. Such particles are useful in delivering, for example, angiogenic growth factors or genes coding for angiogenic growth factors into the coronary arteries of the heart or the heart muscle, as well as other therapeutic agents into organs or tissues or blood vessels feeding the same to achieve a desired effect.

Abstract: The present invention relates to a composition or article containing at least one oxidizing agent and at least one reducing agent, wherein the equivalent ratio of the at least one oxidizing agent to the at least one reducing agent is greater than 1:1, and the article is exothermic when wet with water, and the use thereof to whiten at least one tooth.

Abstract: A therapeutic composition comprising a drug and a polyitol, a dosage form comprising the therapeutic composition, and the method of using the therapeutic composition and the dosage form are disclosed for an indicated therapy.

Abstract: A pharmaceutical composition comprising at least one pharmaceutically active agent that is pH dependent, at least one non-pH dependent sustained release agent, and at least one pH dependent agent that increases the dissolution rate of the at least one pharmaceutically active agent at a pH in excess of 5.5. Such compositions have minimized pH-dependent dissolution profiles or pH-independent dissolution profiles.

Abstract: The present invention provides a dual release solid dosage form containing a first composition that releases a neuraminidase inhibitor, such as oseltamivir, zanamivir, or peramivir, in a controlled manner and a second composition that releases an H1 antagonist in a rapid and/or immediate manner. A wide range of H1 antagonist antihistamines, especially fexofenadine and loratadine, can be used in this device. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. The device is useful for the treatment of respiratory congestion and other viral infection associated symptoms.

Abstract: The present disclosure relates to novel dosage forms, drug delivery regimens, methods and pharmaceutical compositions which optimize the therapeutic effects of active therapeutic substances through the application of the concept of uneven dosing.

Abstract: There is provided an orally deliverable pharmaceutical composition comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility such as celecoxib and a release-extending polymer. The composition is useful in treatment of cyclooxygenase-2 mediated conditions and disorders by once-a-day administration.

Abstract: A dosage form comprises: (a) at least one active ingredient; (b) a core; and(c) a shell which surrounds the core, wherein the shell is substantially free of pores having a diameter of 0.5-5.0 microns, and the shell comprises a first shell portion and a second shell portion which are compositionally different and the dosage form provides a modified release profile of the active ingredient upon contacting of the dosage form with a liquid medium.

Abstract: The present invention concerns the use of pregelatinized starch to prevent dose-dumping from a hydrophilic controlled release formulation. It also concerns a hydrophilic controlled release formulation, more in particular a hydrophilic controlled release matrix formulation, and solid dosage forms prepared therefrom, preferably for once daily oral administration. The hydrophilic controlled release formulation comprises pregelatinized starch, one or more active ingredients, one or more viscous hydrophilic polymers and optionally pharmaceutically acceptable formulating agents. Preferred hydrophilic polymers include hydroxypropyl cellulose and hydroxypropyl methylcellulose.

Abstract: The present invention relates to a process using ultrasonic cutting for the preparation of an oral delivery device comprising a core which includes a pharmaceutically active agent covered by an outer coating which includes one or more openings communicating from the exterior of the device toward the core.

Abstract: A biocide comosition useful for industrial materialsl comrising at least one metal oxide and at least one metal salt, wherein said at least one metal oxide is in a molar ratio of between 4:1 and 1:2 with said meal salt. The invention additionally relates to a process for roducing a biocide composition, comprising the steps of mixing a metal salt solution with at least one metal oxide in a molar ratio of between 4:1 and 1:2 oxide to salt and drying the resultant mixture thereby forming a cement powder.

Abstract: The present invention provides a composition for selectively delivering an active agent to a portion of an organism. The composition comprises first and second polymer portions, having first and second functional groups attached as a side-chain thereto, respectively. The first and second functional groups form cross-links between the first and second polymer portions. The cross-links are capable of being broken by a substance of the organism, thereby resulting in release of the active agent. The composition provides a novel means for controlling the selective release of the active agent in the organism.

Abstract: Disclosed are porous biocompatible polymers in the form of hydrogels, methods of preparing the hydrogels, and methods of using the hydrogels, e.g., in vitro cell culture and body implants.

Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.

Abstract: PHA containing a novel 3-hydroxy-thioalkanoic acid unit having a highly reactive thienyl group in a side chain thereof, and a method of producing the same are provided. Specifically, 5-(2-thienylsulfanyl) valeric acid represented by Chemical Formula [4] below and 6-(2-thienylsulfanyl) hexanoic acid represented by Chemical Formula [5] below are provided. Further, a method of producing PHA, comprising the step of collecting PHA from cells of a microorganism cultured in a medium containing the valeric acid or hexanoic acid, and a novel PHA represented by Chemical Formula [1] below are provided.

Abstract: A solid, oral, controlled release dosage form comprising a therapeutically effective amount of an opioid compound, or a salt thereof, a matrix-forming polymer and an ionic exchange resin.

Abstract: Methods are provided for preparation of a coating on one or more microprojections of a microprojection array using wetting agents either as a pretreatment of the microprojection surfaces or incorporated in the coating formulation along with the active agent.

Abstract: A method and apparatus for controlling the migration of binder liquid in a bulk powder. The bulk powder may be deposited in a powder bed and contains at least two different substances, each in powder form. One substance gives the printed part its bulk properties, forms most of the powder, and preferably is either insoluble or not significantly soluble in the binder liquid. The other powder substance is a migration control substance. Upon interaction with the binder liquid, this substance may absorb the binder liquid and form a gel or dissolve into the binder liquid increasing viscosity thereby inhibiting binder migration. No chemical reactions occur between the binder liquid and any of the substances in the powder bed. In another embodiment of the instant invention, binder migration may be further controlled by first printing a barrier region in the powder bed containing the migration control substance.

Abstract: The invention relates to solid particles for transportation of pharmaceutically active substances, to processes for the preparation thereof, to medicinal drugs containing said particles, and to the use of said particles for various specific indications.

Abstract: A bone repair material is described that is of putty-like consistency, particularly useful for repairing dental bony defects such as those caused by bone loss resulting from moderate or severe periodontitis, augmenting of bony defects of the alveolar ridge, filling tooth extraction sites, or sinus elevation grafting. The repair material includes a porous, resorbable particulate that is bone-derived or derived from bone-like hydroxyapatite or synthetic hydroxyapatite; and, a resorbable carrier, such as high molecular weight polysaccharides, such as hyaluronic acid. A high concentration of particulate in the putty enhances bone repair and requires a high concentration of carrier to retain the putty at the defect site. For a particulate density of about 1.2 g/cc such as PEPGEN P-15® Bone Graft, a preferred formulation comprises about 55% percent by weight of the putty suspended in a hyaluronic acid gel of about 1.

Abstract: This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprise a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide and (b) fat-soluble vitamins. The therapeutic antibacterial/antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the antibacterial/antifungal-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.

Abstract: Composition of Hypochlorous acid characterized because it has the following chemical composition

Abstract: A method for treating severe tinnitus is disclosed. The method of the present invention comprises implanting a catheter into a patient and administering a drug formulation or fluid comprising a therapeutic agent intrathecally into the patient's cerebrospinal fluid.

Abstract: The present invention is directed to a method for increasing the bone mineralization of a human, and more preferably an infant or toddler. The method comprises administering to said human a source of calcium and a fat blend that is low in palmitic acid. The enhanced mineralization results in the production of a higher peak bone mass and correspondingly lowers the incidence of osteoporosis.

Abstract: Therapeutic anti-fatigue compositions for administration to a subject including an active combination of a compound of magnesium and sulfur such as magnesium thiosulfate and a mixture of vitamins including A, B6, B12 and D. The combination is present in the composition in an amount sufficient to treat the symptoms of fatigue in a subject. Methods of using such compositions for treating or managing fatigue are also encompassed by the invention.

Abstract: A method is disclosed comprising placing about thirty-two fluid ounces of water into a receptacle, placing the receptacle with water on a burner and bringing the water to a boil, ceasing to heat the water, adding about one teaspoonful or five grams of tea beverage flavorant to the water; and brewing the combination of the water and the tea beverage flavorant for about three to five minutes. The method may further include filtering out any solid tea in the combination of water and tea beverage flavorant, and consuming the combination of the water and the tea beverage flavorant.

Abstract: The present invention is directed toward a method for inhibiting COX-2 in an organism. In particular, the method is preferably directed toward selectively inhibiting COX-2 in an organism. The method comprises administering to the organism an organic extract isolated from a non-edible plant wherein such extract inhibits COX-2 . A method to purify a composition that exhibits COX-2 inhibition and COX-2 selective inhibition from the organic extract is also provided. In addition, a method for treating and/or preventing COX-2 mediated inflammation or inflammation-associated disorders in an organism is provided.

Abstract: The invention relates to a dietary supplement consisting of an aqueous extract of red vine leaves and an acceptable carrier which prevents and reduces the discomfort relating to mild-to-moderate chronic venous insufficiency of the legs.

Abstract: Remedies for allergic diseases obtained by mixing shoots of plants belonging to the family Pinaceae with water and saccharides followed by spontaneous fermentation. As the plants belonging to the family Pinaceae, it is preferable to use plants belonging to the genus Pinus. These remedies, which enable complete recovery in a short administration time without showing any side effects, are useful as remedies for allergic diseases, in particular, asthma and atopic dermatitis. Also, a yeast isolated from these remedies for allergic diseases is provided.

Abstract: A method of manufacturing metal spheres to prevent irregularities on the surface of the metal spheres. The method reduces the manufacturing time and makes it easy to manufacture extremely small diameter metal spheres.

Abstract: An extrusion molding apparatus comprises a shaping die for producing a ceramic molded product, and a screw extruder having built therein an extruding screw (40) for mixing while leading a ceramic material forward. The extruding screw (40) includes a pressing screw portion (410) having a first lead (411) and a dispersing screw portion (420) having a second lead (421) adjacent to a forward end (412) of the pressing screw portion (410). The second lead (421) is formed in such a manner that the rear ends of all the second lead surfaces (426) at the rear end (422) of the dispersing screw portion (420) and the forward end of the first lead surface (416) at the forward end (412) of the pressing screw portion (410) are displaced from each other.

Abstract: The extruding apparatus has the molding die to form the ceramic molding, the screw extruder containing the extrusion screw to knead and guide the ceramic material toward the molding die. The extrusion screw is comprised of the pressure screw part and the diffusion screw part. The diffusion screw part provided at the front end of the extrusion screw has a diameter greater than the screw diameter of the pressure screw part.

Abstract: This invention concerns an apparatus for producing seamless plastic tubes. It has an injection head to which molten plastic material is fed by an extrusion device. The injection head has a plate-shaped distribution device 13a, 13b having an intake opening 20 into which the feed passage 17a, 17b for the molten plastic material opens. In the distribution device, distribution passages 14 extend in a star configuration from the intake opening 20 and extend perpendicularly to the axis of the injection head, wherein each distribution passage 14 has a straight radial passage portion 14r and three branch passages 14z which branch therefrom and which each go into arcuate passage portions 14k which, in the region of the periphery of the distribution device, communicate with the annular gap 25 of the injection head, with the adjacent ends at a respectively identical angular spacing, and they each introduce a respectively identical volume flow into the annular gap 25.

Abstract: There is provided a mold component which makes it possible to mold a substrate for an optical recording medium which enables a functional layer having a uniform thickness to be formed thereon without using a resin-coating assisting member. A stamper holder holds a stamper thereon, and has a generally hollow cylindrical shape. An insertion hole formed through a central portion of the stamper has a diameter which is larger than an outer diameter of a cavity-side end of the stamper holder at a higher temperature of the holder than a normal temperature, and is slightly smaller than the outer diameter at the normal temperature of the holder. The cavity-side end inserted into the insertion hole at the higher temperature of the stamper is grasped by a rim of the insertion hole which is reduced in diameter at the normal temperature of the stamper.

Abstract: The invention relates to a clamping device for an injection molding machine for plastics, including a fixed platen (11) which is connected to a moving platen (12) by means of a toggle mechanism (13). A hollow-shaft motor (7) is provided to cooperate with a spindle (21) for operating the toggle mechanism, wherein the hollow-shaft motor (7) is connected to the toggle mechanism (13). According to the invention, the spindle (21) is arranged in a rotationally fixed manner, the end of the spindle (21), facing the moving platen (12), is in engagement with the rotor (6) of the hollow-shaft motor (7), and the stator (4) of the hollow-shaft motor is connected with the toggle mechanism (13). Preferably, a spindle nut is fixed in the rotor (6) for engagement with the spindle (21), preferably in the form of a recirculating ball screw.

Abstract: A method of producing an animal feed that is free from transmittable degenerativeencephalopathies is provided. Central to the method is alkali treatment of animalmaterial at a pH of at least 8.5 under temperature conditions below 100 C. at atmospheric pressure. This method provides a decontaminated animal feed produced under relatively low temperature and pressure conditions that are achievable instandard animal carcass rendering facilities.

Abstract: A breath-freshening pet food composition comprising at least 40 ppm by weight of one or more plant extract(s), preferably selected from essential oils.

Abstract: A polyamide-based sausage casing suitable for use with uncooked meats such as chorizo is disclosed. A polyamide resin is blended with a silicon-based barrier control agent, preferably a polyhedral oligomeric silsesquioxane, to increase the permeability of the sausage casing. The resultant blend can be biaxially stretch-oriented to produce a single-layered polyamide-based sausage casing suitable for use with uncooked sausage meats such as chorizo, and specifically suitable for the gas and moisture permeability needed during the curing process for uncooked sausage meats. Such polyamide-based casings can also be employed for cooked sausages by choosing a silicon-based barrier control agent that increases gas and moisture barrier, thereby increasing shelf-life for unpeeled sausages. A method for improving the peelability of cooked sausage casings by injecting a thin coating of a releasing agent, without the addition of a surfactant, into the sausage casing during the shirring process is also disclosed.

Abstract: A process for stabilising a beverage against haze formation comprises treating the beverage with a stabilising agent comprising a particulate silica having a mean pore diameter of at least 6 nm and which has been modified by interaction with a water-soluble polymer having pendant pyrrolidone groups, the polymer being present on the silica in an amount from 5 to 35 per cent by weight with respect to anhydrous weight of silica.

Abstract: An anatomically correct candy novelty made of an exterior layer of confectionery material that represents the skin and flesh of an anatomically correct human body part, and an interior layer of hard candy material that represents the skeleton of the same anatomically correct human body part. The human body parts include, for example, a skull and face on a stick, a hand and a thumb on a stick. The exterior layers of confectionery material can also be made of chocolate, marshmallow, taffy, etc.

Abstract: The present invention pertains to the use of a degraded and cross linked starch in a food coating or batter composition for food products. Surprisingly, it has been found that by virtue of the use of this specific starch, the textural properties and in particular the crispiness of a coating on a food product are significantly improved.

Abstract: A food package for sliced food products to be maintained with a fluffed appearance, the package including a rigid base member forming a compartment for receiving the food product and a rigid lid sealed to the compartment. Advantageously, the base member includes a bottom wall and side wall portions that are configured to engage the food product to hold the slices in a fluffed arrangement thereof. Preferably, one or more tapered side wall portions hold the food product upwardly toward the lid and inwardly toward a center of the package. In preferred embodiments, the base member and lid provide a rigid-rigid construction of the food package. In preferred embodiments, the food package is also configured to stand-up in a vertical display orientation and does not require the food product be contained within a sealed pouch within the compartment.

Abstract: There is described packing (2) of cardboard and shaped as a tube, preferably horizontal, or a box for use in cooking dough products (38) and other fast-food products, such as pizzas, pita breads, French loaves, hamburgers, calzones, spring rolls, or breaded products, e.g. breaded chicken or fish pieces, in a microwave oven. The packing has a susceptor coating (4) on parts of internal areas, where a lower part of the packing has such a shape or is formed with such shaped spacers, by way of example legs (8,30), that provide access for ventilation for a part of the underside of the packing. The packing (2) at the underside part (16) and preferably in one or more side walls (6,24) have ventilation openings (36), the mutual position and shape of which are adapted to the shape of the packing, of the dough item and/or of the product. The packing according to the invention may be placed in an outer packing that by way of example consists of a plastic bag.