Abstract: Devices, systems, methods and kits are provided for delivering interventional devices to a target location with a body. Such interventional devices particularly include fixation devices or any devices which approximate tissue, such as valve leaflets. The delivery devices and systems direct the interventional device to the target location through a minimally invasive approach, such as through the patient's vasculature, and provide for manipulation of the interventional device at the target location, such as to approximate tissue. Optionally, the delivery devices and systems may provide for decoupling of the interventional device, allowing the interventional device to be left behind as an implant.

Abstract: Endoscopic devices and methods used for fastening multiple tissue layers, such as, for example, an endoscopic fundoplication procedure, are disclosed. The device may include, for example, an elongated tubular member having a proximal end for extending outside of the body and a distal end for positioning proximate the multiple tissue layers, a grasper configured for positioning proximate the distal end of the tubular member and for grasping at least one of the multiple tissue layers, a device coupled to the distal end of the tubular member for folding the multiple tissue layers together, a tissue fastener configured to be inserted into the tissue layers to hold the tissue layers together, and a fastener head for inserting the tissue fastener into the tissue layers.

Abstract: Surgical instrumentation and methods for performing a bypass procedure in a digestive system incorporate laparoscopic techniques to minimize surgical trauma to the patient. The instrumentation includes an outer guide member dimensioned for insertion and passage through an esophagus of a patient and defining an opening therein extending at least along a portion of the length of the outer guide member, an elongate anvil delivery member at least partially disposed within the opening of the outer guide member and being adapted for longitudinal movement within the outer guide member between an initial position and an actuated position and an anvil operatively engageable with the delivery member. The anvil includes an anvil rod defining a longitudinal axis and an anvil head connected to the anvil rod.

Abstract: A surgical instrument, a snap-on guide and method capable of being used for closure of fascia and other laparoscopic procedures that use large operative ports or trocars and is intended to help prevent post-operative hernia defects and is also used to stop acute bleeding from the abdominal wall. The instrument shaft with the needle tip is attached to a hand piece allowing the operator to control the retractable grasping surface. The needle guide directly applies onto the shaft of a trocar and it slides down to the level of the subcutaneous tissue helping the operator to place the needle. Once the suture is passed through the abdominal wall, it is released then the needle is re-inserted through the opposite “guide port”. The suture creates an intra-abdominal loop of suture outside the abdomen. Suture ends will be tied, allowing closure of the fascial defect within the abdominal wall.

Abstract: A device is disclosed for introducing a flexible elongated element through at least two portions of a subject. In a preferred embodiment, the device includes a proximal end and a distal end, and an advancement unit for longitudinally advancing the flexible elongated element toward the distal end of the device such that a proximal end of the elongated element may exit from the distal end of the device with sufficient force to pass through the subject. The device also includes a curved die at the distal end of the device for imparting a looping configuration to portions of the flexible elongated element exiting the distal end of the device, and a curved guide at the distal end for receiving the looped flexible elongated element as it returns to the distal end of the device. In a further feature of the invention, a cutting mechanism is provided to permit the looped flexible elongated element to be separated from the remainder of the flexible elongated element.

Abstract: An implantable prosthesis for repairing an anatomical defect, such as a tissue or muscle wall hernia, including an umbilical hernia, and for preventing the occurrence of a hernia at a small opening or weakness in a tissue or muscle wall, such as at a puncture tract opening remaining after completion of a laparoscopic procedure. The prosthesis includes a patch and/or plug having a body portion that is larger than a portion of the opening or weakness so that placement of the body portion against the defect will cover or extend across that portion of the opening or weakness. At least one tether, such as a strap, extends from the patch or plug and may be manipulated by a surgeon to position the patch or plug relative to the repair site and/or to secure the patch or plug relative to the opening or weakness in the tissue or muscle wall. The tether may be configured to extend through the defect and outside a patient's body to allow a surgeon to position and/or manipulate the patch from a location outside the body.

Abstract: A tissue fastener comprises a shaft having a member disposed thereon for lodging the shaft within the tissue, the shaft having a region that is relatively flexible to render a tissue engaging head disposed at a proximal end of the shaft movable with respect to the shaft. In one embodiment, the region comprises substantially an entire length of the shaft and is made from flexible material, such as a mesh, onto which the member and the head are molded. In another embodiment, the shaft comprises generally rigid material, and the region comprises a flexible joint between the shaft and the head. The flexible joint comprises a breakable (e.g., frangible) section of the shaft, and a flexible member (e.g., a plurality of filaments or a flexible tube) extends between the shaft and the head past the breakable section.

Abstract: The present invention is directed to novel apparatus for use in medical procedures relating to tubular body fluid conduits. According to a first aspect of the invention, a filter apparatus is provided for delivery over a guidewire within a tubular body conduit, such as a blood vessel. The filter apparatus comprises: (a) a filter element transformable between a collapsed state and a deployed state, wherein the filter element is adapted to filter particulate matter from fluid within the tubular body conduit while in the deployed state; and (b) a locking member comprising one or more electroactive polymer actuators which switch the locking member between (i) a locking state wherein the locking member securely engages the guidewire and (ii) a release state wherein the locking member is movable along the length of the guidewire. According to a second aspect of the invention, a connector apparatus is provided for use in making an anastomotic connection between first and second tubular fluid conduits in a patient.

Abstract: A high-energy density magnetic particulate is mixed with a biocompatible material to form a composite. The composite may be formed into a sheet, which may be rolled into a tube and laser-cut to form at least one medical device, such as one piece of a multi-piece anastomosis device. The device includes a number of interconnected struts, which may be sized such that any portion of the member placed in the bloodstream is substantially non-thrombogenic. A magnetic field is induced in the composite.

Abstract: The present invention provides devices and associated methods for delivering side-to-side and end-to-side anastomotic connectors to join any two (or more) vessels together such that fluid communication is established between the lumens of the two or more joined vessels. The systems of the present invention employ one or more deployment mechanisms over which the anastomotic connector is positioned for delivery and subsequently deployment within a vessel. The deployment mechanisms may be inflatable balloons or expandable baskets or a combination thereof or the like, which, when inflated and/or expanded, cause one or more portions of the anastomotic connector to deploy.

Abstract: A vascular attachment device (800) seals an opening between two blood conduit tips, where the device comprises a ring element (752); a plurality of fingers (754) mounted on the ring element (752) and adapted to seal at least a portion of an opening between the two blood conduit lips by compressing at least two lips between at least one finger (754) and the ring element (752); and at least one puller spike (812) adapted for pulling, inside the body, at least one of the lips to a space defined between the finger (754) and the ring element (752).

Abstract: The invention relates to a device for connecting a cannula (and/or tube) made of a flexible material with a tube.

Abstract: A surgical ligation clip capable of remote deployment through a catheter.

Abstract: An elongate tubular body extends between a rotatable cutter and a control. The cutter is connected to the control with a rotatable element. A vacuum is applied through an annular passage defined between the tubular body and the rotatable element. The cutter has at least one radial projection which cooperates with at least one stationary element on the tubular body to cut material drawn into the tubular body. Material that has been processed by the cutter is aspirated through the tubular body for disposal.

Abstract: The present invention provides improved devices and methods for making a small incision with a surgical scalpel through skin overlying an intercostal space to establish an access tract for the subsequent placement of minimally invasive direct cardiac massagers, chest tubes, defibrillation electrodes, and the like. A sheathed scalpel according to the present invention comprises a handle having a proximal end and a distal end, a cutting blade attached to the distal end of the handle and having a cutting edge and a tip, and a sheath attached to the handle and having a central passage configured to receive the blade. The sheath covers the blade when the blade is retracted within the central passage and exposes the cutting edge of the blade but not the tip when the blade is advanced within the central passage.

Abstract: In one aspect, a body fluid sampling device is provided using a penetrating member to extract fluid from an anatomical feature. The device comprises a penetrating member actuator for moving the penetrating member inbound towards the anatomical feature and a non-spring based, penetrating member retractor for moving the penetrating member outbound away from the anatomical feature. The penetrating member actuator may be adapted to move the penetrating member at a velocity greater than a velocity achieved by the penetrating member retractor.

Abstract: A tracheostomy dilator moulded from a plastics material is formed with an S shape having a flexible, tapered patient end region for insertion to the trachea. A handle region at the opposite end has a substantially constant diameter along its length. A passage along the dilator receives a guide member, the tip of the patient end of the dilator making a stepless transition with the surface of the guide member.

Abstract: An improved method and apparatus is provided as a system to deliver a composition, preferably a medical or pharmaceutical composition or active, through the stratum corneum of skin, without introducing bleeding or damage to tissue, and absent pain or other trauma. The dimensions and shapes of the microelements are controlled so as to control the penetration depth into the skin. The microelements can be “hollow” such that passageways are created therethrough to allow the composition to flow from a chamber, through the microelements, and into the skin. Alternatively, the microelements can be “solid,” and the composition is applied directly to the skin just before or just after the microelements are applied to the skin surface to create the openings in the stratum corneum. Another alternative embodiment uses cylindrical microstructures that are rotatably applied to the skin and which penetrate through the stratum corneum; and which can dispense fluid by various different structures.

Abstract: An auxiliary surgery tool includes: a handle, a protruding portion generally formed as a conical shape on a front portion of the handle, and a probe portion formed on a front end of the protruding portion, whereby upon insertion of the probe portion into a resected organ part or canal and upon a forward thrusting of the protruding portion, the resected organ part or canal will be gradually bulged, protruded or even unwound for enhancing a smooth and safe suturing for successfully anastomosing the damaged organ part such as a resected rectal poriton.

Abstract: A mechanical bone tamping device for osteoporotic repair include a pair of arms mounted on a spreading mechanism such as a screw jack. The mechanism is introduced into a small hole in a vertebra through a cannula, and is then operated to spread the arms apart, forming a cavity which may be filled with cement to fortify the vertebra.

Abstract: Described are methods and devices relating to reconnecting the urethra and bladder after a radical prostatectomy, wherein the devices incorporate tissue approximating structure to maintain contact between a severed bladder neck tissue and a severed urethral stump tissue, preferably without the use of sutures.

Abstract: The present invention provides a catheter positioning system which serves to control and stabilize a distal end of a catheter at a treatment site within a patient so that a medical procedure can be performed with accuracy. Generally, the positioning system operates by providing a deformable mechanical members at the distal end of the catheter which can be operated from the proximal end of the catheter to extend radially outward to engage surrounding tissue adjacent to treatment site. In one embodiment of the invention a flexible superstructure comprising the plurality of flexible veins extending longitudinally along the distal end of the catheter can be deformed to bow radially outward to engage surrounding tissue. The distal tip of the catheter joined to one of the veins was correspondingly displaced or rotated angularly as the veins bow outward.

Abstract: Medical devices capable of exhibiting stress-induced martensite, but which do not exhibit stress-induced martensite during deployment or removal. The medical devices are sized and proportioned such that deformation of the device during deployment or removal is elastic, thus avoiding stress-induced martensite during deployment and removal. The use of stress-induced martensite materials decreases the temperature sensitivity of the devices. The SIM materials also allow the medical devices, while in use inside the body, to repeatedly deform and revert to their original shape at constant force without metal fatigue.

Abstract: A device for the occlusion of a vascular defect includes a first sheet and a second sheet which may be formed from a material which is the same as or different from the first sheet. At least one sheet functions as a securement member, and at least one sheet functions as an occluding member. The first sheet may be replaced by an alternative securement structure. At least one sheet may be coated with a biocompatible material for promoting integration with the vasculature and/or healing of the vascular defect.

Abstract: The present invention relates to a vascular filter which can be placed in a blood vessel, for the purpose of intercepting thrombus, and which has improved structural features for enhancing position stability at the desired site. These features may include improved barbs or anchor designs. An example of an improved anchor for retaining a vascular filter in position includes for example cutting a barb member from a circumferential side of a filter member or rib, or bending part of a barb slightly in an outward direction to form a gentle spring, or a bevel or bend of an outwardly extending barb toward the longitudinal direction. The various features of the present invention may be used singly or in any combination, as desired in a particular vascular filter.

Abstract: A single-wire expandable cage for an embolic filtering device includes a single cage wire coupled to an elongated member, such as a guide wire, and adapted to expand from an unexpanded position to an expanded position in a patient's body vessel. The wire includes a first end and a second end which are coupled to the guide wire. A filter element is attached to the single-wire cage. The single-wire cage may be rotatably mounted to the guide wire or may be slidably disposed on the guide wire to allow the composite cage and filter element to be slid over the guide wire in an over-the-wire fashion once the guide wire is delivered to the target location in the patient's vasculature. One embodiment of the single-wire cage utilizes an offset arrangement in which the guide wire remains extended along the wall of the body vessel once the single-wire cage is deployed. Another embodiment of the device centers the guide wire within the body vessel.

Abstract: The present invention relates to a retrievable medical filter which can be placed in a blood vessel or other body passage. The filter has improved structural features for enhancing its performance, including deployment, filtration and position stability at the desired site, as well as retrievability. The filter may preferably have a hook structure that provides multiple retrieval surfaces, or may be provided with anchors for removably retaining the filter in position. A filter may be designed with one end being customized for retrieval and the other end being customized for position retention, in which case a cartridge may be provided to ensure proper orientation of the filter during delivery.

Abstract: A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter.

Abstract: A barbed suture for connecting tissue, and a combination surgical needle with a barbed suture. The suture includes an elongated body and a plurality of barbs projecting from the body. Each barb causes the suture to resist movement in an opposite direction from which the barb faces. The disposition of the barbs on the body may be staggered, twist cut multiple spiral, overlapping, or random. Also, the configuration of the barbs may be a certain spirality angle &agr;, barb cut angle &THgr;, barb cut depth, barb cut length, barb cut distance, corrugated barb underside, arcuate barb base, or varying barb size.

Abstract: A suture anchor is provided which includes an attachment formation for attaching a suture to the anchor, the attachment formation being configured to allow relative movement between the suture and the anchor in an operative direction and to inhibit relative movement between the suture and the anchor in an operative direction. Typically, the suture anchor includes two attachment formations arranged in side by side fashion. In certain embodiments, the attachment formation is defined by a passage that extends through the anchor, the passage being shaped and dimensioned to inhibit retraction of the suture in the operative direction. The attachment formation and the anchoring portion may be composite or integrally formed. The invention extends to a suture anchor attachment component for attaching a suture to a suture anchor and to a method of attaching tissue to an anchoring substrate. Further, the invention also extends to a suture anchor insertion tool.

Abstract: A novel nipple protection device designed to prevent the nipple of a pacifier or bottle, used by a mammal, from contacting the ground when dropped is disclosed. The basic form of the invention has fixed guards, on each side of a nipple, attached to a housing, which protrude beyond the nipple and prevent it from touching the floor if it falls. The guard members can be rigid or flexible. In another embodiment, the guard members are hinged and light springs are used to partly close them against the mammal's cheeks when in use or around the nipple when the pacifier or bottle falls. A retractable nipple may also be included with either the fixed or pivotal guard designs to further protect the nipple from contamination when dropped. Finally, another variation is to replace the nipple with a straw and the bottle with any other container.

Abstract: An apparatus and method for pacifier withdrawal are disclosed. The apparatus comprises a plurality of successive pacifiers wherein each pacifier has a handle, a nipple connected to said handle, and a shield interposed between the handle and the nipple. Each successive pacifier has a nipple which is shorter in length than its predecessor. The invention may be practiced as a set of complete pacifiers, as a single pacifier with interchangeable nipples, or as a single pacifier having a nipple which retracts into the handle to shorten its exposed length. The method of using the pacifier withdrawal apparatus is to provide the infant with a first pacifier having a full length nipple and to allow the infant to use the first pacifier for a specified time period in order to become accustomed to it.

Abstract: An expandable stent for percutaneous procedures comprises a tubular structure disposed about a longitudinal axis and a plurality of fingers. The plurality of fingers, upon expansion of the stent, extends from the tubular structure about a second longitudinal axis which is angularly offset from the first longitudinal axis. At least one of the plurality of fingers has a length that is greater than that of the other fingers.

Abstract: Magnetic anchoring devices are disclosed herein. Expandable devices that are inserted into the stomach of a patient are attached to its interior wall by magnetically coupling. Such expandable devices, like inflatable balloons, comprise at least one magnetic device, which may be a magnet, a magnetizable material, or a magnetic metal. The magnetic device may be positioned on the external or interior surface of the expandable device or may be integral thereto. The magnetic device is magnetically coupled to a magnetic anchor positioned on a surface of the stomach wall. In this way, the expandable devices are anchored to the stomach walls, preventing migration of the device to other areas of the body where they may become obstructions and pose health risks.

Abstract: Apparatus and an associated method are provided for detecting a cardiac arrhythmia and delivering cardioversion therapy after first delivering a prepulse inhibition stimulus directly to the central nervous system for inhibiting cardioversion pain perceived by the patient. Circuitry for controlling and delivering a prepulse stimulus may be included in the cardioverting device or in a separate stimulating device that is in communication with the cardioverting device. The prepulse stimulus is delivered directly to the spinal cord via a spinal cord lead at a predetermined time interval prior to cardioversion shock delivery.

Abstract: The invention is directed to techniques for applying overdrive pacing to one or both atria following termination of an AF episode, to prevent a recurrent AF episode. An implantable medical device such as a pacemaker applies overdrive pacing according to overdrive pacing parameters, and sets the parameters as a function of the response of the patient to overdrive pacing. The parameters may be adjusted upward or downward, so that overdrive pacing may be applied effectively but not over-applied.

Abstract: A defibrillation circuit generates a defibrillation pulse and includes a patient-parameter compensator that causes the pulse to have a predetermined characteristic regardless of the value of a patient parameter. For example, the circuit can generate defibrillation pulses that have a desired shape, decay rate, voltage level, current level, and/or energy level regardless of the patient impedance. Consequently, a defibrillator that includes the circuit is likely to be more effective than prior defibrillators in restoring normal heart rhythms to patients having an atypical value for a parameter such as impedance.

Abstract: An implantable cardiac stimulation device is equipped with an isolation system capable of attenuating or eliminating induction currents flowing through the stimulation device by eliminating induction loops. The isolation system comprises a magnetic insulator configured to shield selected components of the stimulation device from external magnetic fields or radio-frequency (RF) signals. The magnetic insulator comprises a plurality of sensors that are configured to detect the intensity of the external magnetic fields and/or RF signals, and a switch bank that electrically isolates certain components of the stimulation device to eliminate the induction loops. The isolation system further comprises an attenuation system comprised of at least one magnetoresistor disposed along potential induction loops to attenuate induction currents when subjected to undesirable external magnetic fields and/or RF signals.

Abstract: The invention is directed to method and process for discriminating supraventricular tachycardia (SVT) with 1:1 atrial to ventricular conduction (AV conduction). Upon detection of a rapid heart rate, an implanted medical device may determine whether the rhythm exhibits insufficient evidence of sinus tachycardia, whether the rhythm exhibits 1:1 conduction, and whether an electrical signal corresponding to the rhythm exhibits a normal morphology. When these tests have been satisfied, the device determines that an SVT with 1:1 AV conduction has been detected.

Abstract: The invention provides techniques for delivering anti-tachycardia pacing therapies to a heart. A medical device for providing anti-tachycardia therapy consistent with the invention may include two or more electrodes located proximate to or within the ventricles and/or two or more electrodes located proximate to or within the atria of a heart for treating ventricular and/or atrial tachycardias. At least some of the pulses within a sequence of pulses of a selected therapy may be delivered via each of the two or more electrodes. The timing of the delivery of these pulses by a particular electrode may be based on a programmed cycle length between consecutive pulses within the sequence and delay periods that are programmed for each electrode for each of these pulses. Thus, different electrodes may deliver the same pulse within a sequence at different times, increasing the effectiveness of anti-tachycardia pacing therapies.

Abstract: The invention is directed to an implantable medical device that stimulates a nerve associated with respiration. The nerve may, for example be a phrenic nerve, and the stimulation may cause a diaphragm of the patient to contract. The implantable medical device receives a signal that indicates a need for increased cardiac output and stimulates the nerve in response to the signal. The implantable medical device may receive such a signal by, for example, detecting a ventricular tachyarrhythmia, sensing a pressure that indicates a need for increased cardiac output, or receiving a signal from a patient via a patient activator.

Abstract: A rate-adaptive pacemaker is disclosed in which a sensor-indicated rate is calculated by adding a function of the measured exertion level to a programmed lower rate limit.

Abstract: Methods and process for detection of myocardial ischemia involve detection and analysis of changes in electrical conduction velocity within the heart to monitor changes in the condition of the cardiac muscle and indicate possible ischemia. Conduction velocity slows considerably when oxygen supply to the heart is reduced. Analysis of electrical conduction velocity can be used to verify the occurrence of myocardial ischemia in a more reliable manner. Changes in conduction velocity may be monitored based on conduction time between electrodes positioned in the left and right ventricles of the heart. The electrodes may be endocardial or epicardial electrodes. In general, the techniques may involve launching a stimulation waveform at one electrode and sensing a local cardiac depolarization at another electrode to assess conduction time.

Abstract: A cardiac pacing device and method for automatically selecting an optimal evoked response sensing vector based on an evaluation of the evoked response signal quality are provided. Electrode switching circuitry allows selection of multiple sensing electrode vectors. Capture detection circuitry provides capture and loss of capture signal characteristics determined during a pacing threshold search to be used in determining evoked response signal quality parameters. An optimal evoked response sensing vector is selected based on evoked response signal quality parameters meeting predetermined criteria for reliable evoked response sensing.

Abstract: Techniques for increase the accuracy of detection of atrial capture may involve determining a ventricular sensing window for ventricular senses associated with atrial test pulses based on observed ventricular senses. For example, an implanted medical device may deliver atrial test pulses to a patient at a time prior to respective atrial pacing pulses to evaluate atrial capture. The implanted medical device observes ventricular senses in response to the atrial test pulses. The implanted medical device may determine a point such as, for example, a midpoint of the ventricular sensing window for the ventricular senses and shift a midpoint of the default ventricular window to the determined midpoint. Further, the implanted medical device may measure patient parameters, such as heart rate and activity level, and determine a ventricular sensing window for ventricular senses associated with atrial test pulses based on the observed ventricular senses and measured patient parameters.

Abstract: A programmer including a user interface, and techniques for programming a rate responsive implantable medical device using such a programmer and user interface are presented. The programmer may retrieve currently programmed rate response parameters and optimization target values of an implantable medical device. The programmer may display the currently programmed rate response parameters and optimization target values via a user interface. The programmer may also generate a current rate response curve and a current target rate histogram, and display the current rate response curve and current target rate histogram via the user interface. The programmer may receive changes to the displayed currently programmed rate response parameters and/or target values made by a user via the user interface, generate a pending rate response curve and/or a pending target rate histogram based on these changes, and display the pending rate response curve and/or pending target rate histogram via the user interface.

Abstract: The invention relates to a method of treating sexual dysfunction. The method includes stimulating sacral nerve roots, S2 and/or S3, with electromagnetic stimulation in or about the sacrum. The stimulation may be achieved with leads terminating in electrodes that extend with an emerging sacral nerve root or extend transverse the sacrum at or about the location of the nerve root to be stimulated. Alternately, spiraled electrodes and nerve cuffs may be used to stimulate the nerve root within the sacrum, as it emerges from the sacrum, or outside the sacrum. In this manner, the selected sacral nerve root may be stimulated to provide genital stimulation and thereby induce orgasm.

Abstract: An improved process using electrostimulation for treating obesity, especially morbid obesity, is provided. The improved method of this invention provides electrostimulation on or along the small intestines, preferably on or along the duodenum and/or jejunum, which provides improved control of obesity. In one embodiment, the process employs stimulation of the lesser curvature at a rate of about 2 to about 30 pulses/minute with each pulse lasting about 0.1 to about 4 seconds such that there is a pause of about 3 to about 30 seconds between the pulses. More preferably, the pulse rate is about 12 to about 14 pulses/minute with each pulse lasting about 0.1 to about 0.5 seconds with a pause of about 4.5 to about 5 seconds between pulses. Preferably, the pulse amplitude is about 0.5 to about 15 milliamps. More preferable, each pulse consists of a train of micro-bursts with a frequency of about 5 to about 100 Hz.

Abstract: A device, system and method for diagnosing and treating gastric disorders is provided. A functional device resides within the patient's stomach and is secured to the stomach wall by an attachment device. The functional device may be a sensor for sensing various parameters of the stomach or stomach environment, or may be a therapeutic delivery device. The functional device in one embodiment provides a device, system and method for gastric electrical stimulation where stimulating electrodes are secured to the wall of the stomach by the attachment device or otherwise. A preferred device includes: at least one stimulating electrode in electrical contact with the stomach wall; an electronics unit containing the electronic circuitry of the device; and an attachment mechanism for attaching the device to the stomach wall. The functional devices may be programmed to respond to sensed information or signals.

Abstract: Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.