Abstract: A low loss high-frequency dielectric ceramic composition for sintering at a low temperature and method of manufacturing the same which is characterized in that excellent dielectric properties such as a much lower sintering temperature and higher quality coefficient and dielectric constant, compared to a conventional high-frequency ceramic composition, a stabilized temperature coefficient, and a temperature compensating property varied according to a composition, are implemented using a low-priced material such as ZnO—Mo (M═Mg, Co, Ni)—TiO2. In addition, Ag, Cu, an alloy thereof, or an Ag/Pd alloy can be used as an internal electrode. Thus, the composition of the present invention can be used as a dielectric material for all sorts of high-frequency devices, such as a multilayer chip capacitor, multilayer chip filter, multilayer chip capacitor/inductor composite device and module, low temperature sintered substrate, resonator or filter and ceramic antenna.

Abstract: A process for the production of a molecular sieve adsorbent blend product with improved performance characteristics produced by preparing a zeolite powder, preparing a highly dispersed attapulgite fiber binder, mixing the zeolite powder with the highly dispersed attapulgite binder to form a mixture, forming molecular sieve adsorbent products into a shaped material and calcining the shaped material, wherein the tapped bulk density of the highly dispersed attapulgite fibers measured according to DIN/ISO 787 is more than about 550 g/ml.

Abstract: A catalyst used in the low-temperature pyrolysis of hydrocarbon-containing polymer materials, and being mainly intended for use in the recycling of rubber waste materials. The catalyst is prepared from a carbon-iron component in the form of microscopic carbon particles and ultra-dispersed iron particles. In order to increase the yield of light hydrocarbon fractions in the condensate and to bind substantially completely the sulphur in the products of the rubber pyrolysis, the catalyst further contains a metal-carbon component. This component consists of the product from the stripping and the pyrolysis of a dispersion that comprises at least one salt of a metal from the group VIII in the periodic table which is capable of decay upon heating in order to form an oxide, wherein the metal is selected from the group comprising iron, nickel and cobalt. The dispersion further includes a carbohydrate as well as a highly volatile solvent.

Abstract: Disclosed is a crystalline silicoaluminophosphate molecular sieve comprising a porous framework structure and at least one single ring aromatic compound within the porous framework structure. The silicoaluminophosphate molecular sieve is used to convert oxygenate feedstock to olefin product. The olefin product is high in ethylene and propylene content, with a high selectivity to ethylene. The silicoaluminophosphate molecular sieve can be included with a binder and other materials in finished catalyst form.

Abstract: The present invention provides a catalyst capable of producing an epoxy compound in high yield and improving the utilization efficiency of the oxidizing agent as well as a method of producing an epoxy compound using that catalyst. A catalyst for producing an epoxy compound by oxidizing a compound having at least one ethylenic double bond with an oxidizing agent, comprising a polyatom-containing heteropolyoxometalate anion (A1) having two defective and/or three defective structure sites and containing silicon as the heteroatom, and an element (E1) being at least one element selected from the group consisting of vanadium, tantalum, niobium, antimony, bismuth, chromium, molybdenum, selenium, tellurium, rhenium, cobalt, nickel, ruthenium, rhodium, palladium, osmium, platinum, iridium, silver, gold, zinc, aluminum, gallium, indium, scandium, yttrium, titanium, zirconium, hafnium, germanium, tin and lanthanoids, and being different from the polyatom.

Abstract: A Ti—O—N film is formed on an SiO2 substrate by sputtering. For example, TiO2 is used as a target and nitrogen gas is introduced into the atmosphere. Crystallization is carried out by a post-sputtering heat treatment. Then a charge separation material such as Pt is supported on the Ti—O—N film. With the fabricated TiO2 crystals, the Ti—O—N film containing nitrogen exhibits a good catalytic reaction by using visible light as acting light. Since the charge separation material captures electrons or positive holes, recombination of electrons and positive holes is effectively prevented, and consequently more efficient photocatalytic reaction is performed. It is preferable to form a photocatalyst material film (Ti—Cr—O—N film) by sputtering the SiO2 substrate by use of TiO2 and Cr as the target in a nitrogen atmosphere. Crystallization is performed by a post-sputtering heat treatment.

Abstract: A heat-sensitive recording material includes, on a support thereof, a heat-sensitive recording layer containing a diazo compound and a coupler.

Abstract: A thermal transfer image-receiving sheet 1 includes a seal part 9 including at least a receptive layer 8, a substrate 7 and a pressure-sensitive adhesive layer 6 which are laminated in the order mentioned; and a release sheet 5 which is separably adhered to the pressure-sensitive adhesive layer 6 of the seal part 9. The seal part 9 is provided with a half cut 2 that is useful for separating a part of the seal part 9 from the release sheet 5. The groove width of the half cut 2 is preferably from 25 to 60 &mgr;m. It is also preferable that the seal part 9 and the release sheet 5 be adhered to each other so that they show continuous and slight changes in peel strength when the seal part 9 is separated from the release sheet 5. The slight changes in peel strength measured in accordance with JIS Z0237-8.3.1 (180 Degrees Peeling Method) are referably in the range of 1 to 10 g/cm. Further, it is preferable that the mean peel strength be from 10 to 75 g/cm.

Abstract: Improved methods and compositions for protecting plants or seeds from plant diseases are provided. Broadly, the compositions comprise (and preferably consist essentially of) saponin, such as triterpene type saponins extracted from quinoa or quillaja. The methods comprise contacting the portion of the plant (e.g., foliage, shoot, etc.) to be treated with a disease-inhibiting or protective amount of the composition. The compositions can also be used to treat plant seeds or tubers prior to planting thereof, as well as soil adjacent a growing plant. The inventive compositions are particularly useful for the treatment, control and/or prevention of bacterial diseases. The saponins of the invention can be applied as liquids or dry particulates, and are especially suited for the treatment of tomato and potato plants and their respective seeds.

Abstract: This invention relates to new herbicidal compositions comprising a mixture of (a) an alkoxypyrimidyloxybenzoic acid derivatives of formula (I): wherein X is a hydrogen atom or a group (C6H5)2C═N—, or an agriculturally acceptable salts thereof, for example alkali or alkaline earth metal salts and (b) a partner herbicide. This invention additionally relates to a method of controlling weeds comprising applying these new herbicidal compositions to a locus.

Abstract: The present invention relates to a herbicidal composition comprising A) one or more sulfonylureas of the formula (I) and/or their salts in which R1 is C2-C4-alkoxy or CO—Ra, where Ra is OH, C1-C6-alkoxy or NRbRc, where Rb and Rc independently of one another are identical or different and are H or C1-C6-alkyl, R2 is halogen or (A)n—NRdRe, where n is zero or 1, A is a group CRfRg, where Rf and Rg independently of one another are identical or different and are H or C1-C6-alkyl, Rd is H or C1-C6-alkyl and Re is H, C1-C6-alkyl or an acyl radical, where Rd and Re may also form a heterocyclic ring and where, if R1 is C2-C4-alkoxy, R2 may also be H, R3 is H or C1-C6-alkyl, m is zero or 1, X and Y independently of one another are identical or different and are C1-C6-alkyl, C1-C6-alkoxy or C1-C6-alkylthio, where each of the three radicals mentioned is unsubstituted or substituted by one or more radicals selected from the group consisting of halogen, C1-C4-alkoxy and C1-C4-alkylthio,

Abstract: The invention relates to novel substituted N-aryl nitrogen-containing heterocyclic compounds of the general formula (I) and to the compounds isomeric to the substituted N-aryl nitrogen-containing heterocyclic compounds of the formula (I), of the formulae (Ia) and (Ib) in which Q1, Q2, R1, R2 and Ar have the meanings given in the description, processes for their preparation and their use as herbicides.

Abstract: Liquid suspensions of particles in non-aqueous solvents are extremely stable over long periods of time with minimum separation of the solvent and no hard packing of the dispersed particles. The suspensions enable a user to rapidly add the suspension to water and to mix at low speeds without generating fugitive dust in the process. In addition, a liquid dispersion can provide an easy to use liquid containing higher concentrations of the active dispersed phase than can be accomplished by simply preparing an aqueous solution of the dispersed phase. Alternatively, highly water-soluble particles may also be suspended which have poor storage, freeze/thaw, or heat/cool stability. In some cases, liquid dispersions can yield controlled release of the dispersed phase because the dispersed phase is not in aqueous solution. The suspensions are environmentally safe and biodegradable and may be used in environmentally sensitive applications, such as for oil well treating fluids for offshore areas.

Abstract: A dispersant that is a reaction product of a polyalkenyl-substituted mono- or dicarboxylic acid, anhydride or ester; and a polyamine, wherein the reaction product has from greater than about 1.3 to less than about 1.7 mono- or di-carboxylic acid producing moieties per polyalkenyl moiety, and the polyalkenyl moiety has a number average molecular weight of at least about 1800, and a molecular weight distribution (Mw/Mn) of from about 1.5 to about 2.0.

Abstract: The passage of a container along a conveyor is lubricated by applying to the container or conveyor a mixture of a water-miscible silicone material and a water-miscible lubricant. The mixture can be applied in relatively low amounts and with relatively low or no water content, to provide thin, substantially non-dripping lubricating films. In contrast to dilute aqueous lubricants, the lubricants of the invention provide drier lubrication of the conveyors and containers, a cleaner conveyor line and reduced lubricant usage, thereby reducing waste, cleanup and disposal problems.

Abstract: This invention relates to improved antioxidant antiwear/extreme pressure compositions consisting of (a) methylenebis(di-n-butyldithiocarbamate) and (b) a diphenylamine derivative of tolutriazole or benzotriazole wherein the (a):(b) mass precent ratio ranges from above about 4:1 to about 50:1 and lubricating compositions containing same.

Abstract: A conditioning shampoo comprising: (a) 8-18 weight % of an anionic surfactant; (b) 0.5-0.8 weight % of a conditioning system comprising: (i) 0.1-0.75 weight % of silicone Quaternium-8; (ii) 0.1-0.5 weight % of a low molecular weight guar gum with a molecular weight less than 100,000 centipoise as an aqueous clear cationic solution of a modified polysaccharide clear cationic solution; and (iii) 0.1-0.5 weight % of Polyquaternium-10; (c) 1.0-6.0 weight % of an amphoteric surfactant; (d) 0.5-5.0 weight % of a member selected from the group consisting of cocodiethanol amide, and cocomonoethanol amide; and (e) the remainder as water.

Abstract: A one step method for the treatment of a non-finished textile component is provided. The method comprises the combination of a bleaching and de-sizing treatment steps into a single step and comprises treating a non-finished textile component in an aqueous treatment solution of a hydrophobic bleaching system and a de-sizing system. Preferred hydrophobic bleaching systems are combinations of hydrogen peroxide and a hydrophobic bleach activator or a hydrophobic peracid. Preferred bleach activators include the alkanoyloxybenzene sulfonates and in particular noanoyloxybenzene sulfonate. The method provides superior fiber protection and fabric strength benefits versus conventional processing as well as allows significant savings in both energy and time due to the elimination of multiple washing and/or drying stages and lower bleaching temperatures.

Abstract: The present invention is a laundry detergent booster liquid composition comprising from about 0.3% to about 7% of a soluble alkali metal carbonate, especially sodium carbonate in an aqueous solution. The booster liquid formulation may contain additional laundry detergent additive materials such as thickening agents, optical brighteners, anti-redeposition agents, surfactants, phosphates, dyes, and fragrances in addition to the alkali metal carbonate.

Abstract: Stable aqueous laundry detergents containing vinly pyrrolidone copolymers are provided. The stable aqueous laundry detergents contain, in addition to the vinyl pyrrolidone copolymers, a combination of anionic and nonionic surfactants.

Abstract: This invention addresses methods and compositions for providing alkyl diphenyl oxide sulfonic acid blends at useful viscosities for use in surfactants such as DOWFAX-containing surfactants. The low viscosity alkyl diphenyl oxide sulfonic acid blend is made by admixing a fatty acid having a carboxylic chain length between 1 and 12 (e.g., formic acid, acetic acid, propionic acid, butanoic acid, pentanoic acid, valeric acid, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, undecanoic acid, or dodecanoic acid into an alkyl diphenyl oxide sulfonic acid reaction product to provide between about 5 weight percentage and about 50 weight percentage of fatty acid in the admixture.

Abstract: Compositions comprising 1,1,1,3,3-pentafluorobutane and more than 5% by weight of at least one non-flammable fluoro compound, and use thereof.

Abstract: The invention relates to a sparingly soluble alkali metal silicate which comprises alkali metal phyllosilicate in finely divided form in a non-phyllosilicatic alkali metal silicate environment of the formula x MI2O.y SiO2, in which MI is an alkali metal and y/x (1.9 to 500): 1; a process for its preparation and its use in detergents and cleaners.

Abstract: A fabric treatment composition comprising a textile compatible carrier and a supramolecular polymer, the supramolecular polymer comprising a building block comprising at least two moieties each moiety having at least 3 groups capable of forming cross-linking hydrogen bonds with other building blocks to form the supramolecular polymer.

Abstract: The present invention relates to a fragrance composition containing a mixture of (9E)-undecenonitrile, (9Z)-undecenonitrile, and 10-undecenonitrile, which can be combined with additional fragrance ingredients, and which is useful in perfumery, and a process of preparing a scented consumer product using the composition.

Abstract: The peptides and derivative metapeptides based upon natural antimicrobial peptides have potent and broad spectrum activity against pathogens exhibiting multiple antibiotic resistance. In addition, they exhibit lower inherent mammalian cell toxicities than conventional antimicrobial peptides, and overcome problems of toxicity, immunogenicity, and shortness of duration of effectiveness due to biodegradation, retaining activity in plasma and serum. The peptides and derivative metapeptides exhibit rapid microbicidal activities in vitro, can be used to potentiate conventional antimicrobial agents, to potentiate other antimicrobial peptides, and are active against many organisms that exhibit resistance to multiple antibiotics currently in existence.

Abstract: A nutritional supplement to be incorporated into the diet of an individual under stress (e.g., chronic stress) is described, comprising a low-glycemic-index carbohydrate, alpha lactalbumin-enriched whey protein, fat, caffeine and a source of 5-hydroxytryptophan (5-HTP). The supplement provides active food-grade ingredients to improve the management of stress and symptoms associated therewith.

Abstract: Compositions and methods for controlling prepathological and pathological protein assembly or aggregation using picolinic acid, analogs, or derivatives thereof are described. The compositions of the invention, capable of solubilizing a conformationally altered protein, comprise a carboxylic acid anion of picolinic acid, its analogs, or derivatives thereof and a cation. According to the methods of the invention, conformationally altered protein assembly or aggregation in an animal is prevented or reversed by introducing the compositions of the invention to the conformationally altered protein. The compositions can be administered systemically by injection, oral administration, inhalation, transdermal, or other routes of administration.

Abstract: The invention described herein relates to the discovery of methods and compositions for the inhibition of growth and/or migration of cells that have the P antigen, including but not limited to, cells of hematopoietic origin and endothelial cells. More specifically, parvovirus capsid particles or fragments of parvovirus capsid proteins are used to manufacture medicaments that can be administered to a subject to inhibit hematopoietic progenitor cell growth (e.g., prior to stem cell transplantation), endothelial cell growth, (e.g., as an anti-tumorigenesis treatment or to prevent restenosis or fibrotic build up following prosthetic implantation), or to prevent disorders that involve the abnormal proliferation of cells that have the P antigen (e.g., polycytemia vera).

Abstract: In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are administered to the vagina prior to sexual intercourse. The lectins immobilize the sperm to render them incapable of fertilization and also bind to the microorganisms to render them non-pathogenic or to the cells to prevent infection by the microorganisms. Lectins can also be administered to treat sexually transmitted vaginal infections. The invention also encompasses a device for to be placed in the vault of the vagina which comprises a ring which surrounds the cervix and a membrane spanning the central aperture of the ring to prevent the direct contact of ejaculate with the cervical tissues. The device is impregnated or coated with lectins and releases them into the vaginal environment over a period of time.

Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.

Abstract: A slow release formulation includes a biocompatible anionic polysaccharide material containing glucuronic acid in the polymer chain.

Abstract: This invention relates to new polypeptide compounds represented by general formula [I]: wherein R1 and R2 are as defined in the description and pharmaceutically acceptable salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious disease including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.

Abstract: Provided are compounds of the formula (1): wherein R′ is hydrogen, methyl or NH2C(O)CH2—; R″ and R′″ are independently methyl or hydrogen; R adn Ry are independently hydroxy or hydrogen; R1 is hydroxy, hydrogen, or hydroxysulfonyloxy; R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy; R2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R=H) forms of the compounds.

Abstract: The present invention concerns therapeutic agents that mimic the activity of Apo-AI amphipathic helix peptide. In accordance with the present invention, the compounds of the invention comprise: a. a Apo-AI amphipathic helix peptide or Apo-AI amphipathic helix peptide-mimetic domain, preferably the amino acid sequence of SEQ ID NO: 7, or sequences derived therefrom by phage display, RNA-peptide screening, or the other techniques mentioned above; and b. a vehicle, such as a polymer (e.g., PEG or dextran) or an Fc domain, which is preferred; wherein the vehicle, preferably an Fc domain, is covalently attached to the Apo-AI amphipathic helix peptide or Apo-AL amphipathic helix peptide-mimetic domain. The vehicle and the Apo-AI amphipathic helix peptide or Apo-AI amphipathic helix peptide-mimetic domain may be linked through the N- or C-terminus of the Apo-AI amphipathic helix peptide or Apo-AI amphipathic helix peptide-mimetic domain, as described further below.

Abstract: The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.

Abstract: A system is described which utilizes a novel system of repressor titration for maintenance of a plasmid useful in gene therapy and production of a recombinant protein. The system utilizes a transformed host cell containing a plasmid including an operator susceptible to binding by a repressor expressed in trans, a first chromosomal gene encoding the repressor, and a second chromosomal gene that is functionally associated with an operator and essential for cell growth, wherein the plasmid is present in the cell in sufficient numbers to titrate the repressor such that the essential gene is expressed, thereby permitting cell growth.

Abstract: The invention concerns novel compounds of formula (I) in which: R1 and R2, which are identical or different, are C6-C23 alkyl or alkenyl radicals, linear or branched or —C(═O)—(C6-C23) alkyl or -c(═O)—(C6-C23) alkenyl, linear or branched. X is the oxygen atom or an amino-NR3 radical, R3 being a hydrogen atom or an inferior alkyl radical of 1 to 4 carbon atoms; n is a positive whole number from 1 to 6; m is a positive whole number from 1 to 6, and when n>1, m can be identical or different. The invention also concerns novel compositions of said compounds and of active substances in particular therapeutically, comprising at least a negative charge for inserting said active susbtances in cells. It concerns in particular novel complexes, of which the active substance consists of one or several nucleic acids, useful for cell transfection.

Abstract: The invention relates to compositions comprising acyl derivates of 2′-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunligth-induced cellular damage, methods for improving wound healing and tissue repair, and methods for ameliorating the effects of aging comprising administering the composition of the present invention to an animal.

Abstract: The present invention relates to a purified, easily produced poly-&bgr;-1→4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a &bgr;-1→4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.

Abstract: A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) wherein R1 is —O(CH2)mR3 or —(CH2)nR3; wherein R3 is an anionic substituent; m is an integer from 1 to 4; and n is an integer from 0 to 4; and wherein R2 is either H or —OH. Each of R1 and R2 can be either meta or para to its respective phenyl ethyl linkage. Compounds having the formula (I) wherein R1 is —O(CH2)mR3 or —(CH2)nR3; R3 is an anionic substituent; m is 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; R2 is H or —OH; and wherein each of R1 and R2 is independently meta or para to its respective phenyl ethyl linkage are also provided, with the proviso that R2 is not para —OH when m is 1 and R3 is —COOH.

Abstract: The present invention provides selective kinase inhibitors of formula (I).

Abstract: The invention provides methods for treating cancer and compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates useful for preparing the compounds.

Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, R4, W, X, and Y are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

Abstract: Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.

Abstract: The present invention is a compound of formula The compound and derivatives or pharmaceutically acceptable salts thereof of the invention have a good affinity and selectivity to the GABA A &agr;5 receptor and are useful for the treatment of diseases related to this receptor.

Abstract: The present invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5, R6, A, X, m and n have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, for example as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

Abstract: The present invention is concerned with the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p represents 0, 1, 2 or 3; q represents 0, 1, 2, 3 or 4; R1 represents hydrogen, C1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyloxy, mercapto, C1-6alkylthio, C3-7cycloalkyl, aryl or C1-6alkyl substituted with mono- or di(C1-6alkyl)-amino, C1-6alkyloxy, aryl or Het; R2 represents cyano or a radical of formula —C(═X)—Y—R5; wherein X represents O or S; Y represents O, S, NR6 or a direct bond; R5 represents hydrogen; C3-7cycloalkyl; aryl or optionally substituted C1-6alkyl; and where Y is a direct bond, R5 may also be halo or Het; R3 and R4 each independently represents halo, haloC1-6alkyl, C1-6alkyl, hydroxy, C1-6alkyloxy, C1-6alkylcarbonyloxy, mercapto, C1-6alkylthio, C1-6alkylsulfonyl, C1-6alkylsulfinyl, haloC1-6alkylsulfonyl, aryl, cyano, nitro, amino, mono- and di(C1-6alkyl)amino o

Abstract: Indole derivatives represented by formula (I): (wherein all symbols are described in the description), a process for the preparation of the same and a DP receptor antagonist comprising it as an active ingredient. Since the compounds of formula (I) binds to and are antagonistic to a DP receptor, they are useful in for the prevention and/or treatment of diseases, for example, allergic diseases (allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma, food allergy, etc., systemic mastocytosis; disorders due to systemic mastocyte activation, anaphylactic shock, bronchoconstriction, urticaria, eczema, etc.), diseases accompanied with itching (atopic dermatitis, urticaria, etc.), secondary diseases caused by behaviors (scratching behaviors, beating, etc.) (cataract, retinal detachment, inflammation, infection, sleep disorder, etc.