Abstract: The invention relates to a process for the oxidation of starch, wherein a root or tuber starch comprising at least 95 wt. % of amylopectin, based on dry substance of the starch, is treated with an oxidizing agent and the resulting product is subjected to an alkaline treatment, said treatment comprising keeping the product for at least 15 minutes at a temperature of 20-50° C. and a pH higher than 10. The invention further relates to an oxidized starch obtainable by said process and to various applications of said oxidized starch.

Abstract: A process for the production of a compound of formula comprising i) silylating a compound of formula then reacting a resulting with a compound of formula R′BS—X′  IVB wherein R′B is hydrogen or trialkysilyl and X′ is as defined above, in the presence of a compound of formula wherein R2, R3 and R4 independently of each another are aryl or alkyl, and R5 is alkyl, perfluorinated alkyl, or aryl; and isolating the desired product.

Abstract: N-formyl hydroxylamines are provided which have the structure wherein R is H, alkyl, alkenyl, aryl-(CH2)p—, heteroaryl-(CH2)p— or cycloheteroalkyl-(CH2)p— R1 is H or COR2 where R2 is alkyl, aryl-(CH2)p—, cycloheteroalkyl-(CH2)p—, heteroaryl-(CH2)p—, alkoxy or cycloalkyl-(CH2)p—, p is 0 to 8, and A is a dipeptide derived from an amino acid or is a conformationally restricted dipeptide mimic. The above compounds are useful in treating hypertension congestive heart failure, renal failure, and hepatic cirrhosis.

Abstract: The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.

Abstract: Processes for preparing a calcium salt of a statin from an ester derivative or protected ester derivative of the statin by using calcium hydroxide are provided. The ester or protected ester derivative is contacted with calcium hydroxide to obtain the calcium salt. Preferred statins are rosuvastatin, pitavastatin and atorvastatin, simvastatin and lovastatin. In processes beginning with a protected statin ester derivative, the protecting group is hydrolyzed during salt formation by contact with calcium hydroxide, or is contacted with an acid catalyst followed by contact with calcium hydroxide.

Abstract: The present invention relates to a process for the synthesis of bis-(substituted-4-quinolyl) disulphides.

Abstract: The present invention provides a process for preparing N-methylparoxetine, an intermediate in the synthesis of paroxetine, by reacting sesamol-tetrabutylammonium salt with CIPMA. The present invention is not limited to the synthesis of N-methylparoxetine, but also includes other similar compounds.

Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, n is an integer 0.

Abstract: The present invention relates to a process for preparing 2-haloalkylnicotinic acids and haloalkylnicotinic acid derivatives starting from halomethyl-substituted enones and 3-dialkylaminoacrylic esters and also to intermediates of the process according to the invention.

Abstract: In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue diffusion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.

Abstract: A process for the preparation heterocyclic indene analogs, especially with the preparation of 4-hydroxycarbazole or N-protected 4-hydroxycarbazole, involves cyclocarbonylation followed by saponification. This process avoids high temperatures and high catalyst loadings.

Abstract: A method for preparing 5-(4-fluorophenyl)-1-[2-((2R,4R)4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide (I), a key intermediate in the synthesis of atorvastatin calcium, is described.

Abstract: Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

Abstract: The method of the invention comprises a process for synthesizing a trans-calanolide A ketone intermediate used in the synthesis of racemic trans-calanolide A. The invention further comprises a method for removing a racemic calanolide B diastereomer from a mixture of calanolide A and calanolide B diastereomers formed in the last step of the synthesis of calanolide A by crystallization.

Abstract: The present invention provides a process for synthesizing 3-fluoroalkoxymethyl-3-alkyloxetanes, suitable as intermediates for preparing various fluorine-containing functional materials, represented by General Formula (Ia): wherein, X1 and X2 independently represent hydrogen or fluorine; Rf represents fluorine or C1-C18 linear or branched perfluoroalkyl; and R represents methyl, ethyl, n-propyl or isopropyl.

Abstract: A novel compound with anthraquinone structure and having the following foluma (I): wherein R1, R2 and R3 each independently is hydrogen, hydroxy, amino or C1-6 alkyl group; R4 is hydrogen, C1-18 alkyl carbonyl, C1-6 alkyl group substituted by at least a functional group; R5 is hydrogen amino or a group of the following formula wherein R1, R2, R3 and R4 are defined as the above; and R and R′ each independently is hydrogen, hydroxyl, amino, C1-6 alkyl group or a group of the following formula wherein R1, R2, R3 and R4 are defined as the above.

Abstract: Disclosed are organometallic compounds derived from Groups VIIb, VIII, IX, and X metals useful as precursors for the formation of metal containing powders and for the chemical deposition of the metals on substrates, particularly for the chemical vapor deposition of metal films suitable for the manufacture of electronic devices. Methods for their use are also disclosed.

Abstract: A process for producing platinum alkenyl polysiloxane complex compounds, especially platinum divinyltetramethyldisiloxane, by reacting a haloplatinum compound with at least one alkenyl polysiloxane in the initial presence of platinum in the form of a platinum complex compound as an autocatalyst and in the initial presence of at least one base in an organic solvent or mixture of organic solvents that can be oxidized by the haloplatinum compound.

Abstract: Compounds of the formula (I) and (Ia) in the form of racemates, mixtures of diastereomers or in essentially enantiomerically pure form, (I), (Ia), where R is hydrogen, C1-C8alkyl, C5-C12cycloakyl, phenyl or phenyl substituted by from 1 to 3 C1-C4alky or C1-C4alkoxy groups; n is 0 or an integer from 1 to 4 and R1 are identical or different substituents selected from the group consisting of C1-C4alkyl, C1-C4fluoroalkyl and C1-C4alkoxy; X1 and X2 are each, independently of one another, secondary phosphino; T is C6-C20arylene or C3-C16heteroarylene; and X2 is bound in the ortho position relative to the T-cyclopentadienyl bond.

Abstract: A new crystalline maganese phosphate composition having an empirical formula: Mn3(PO4)4.2(H3NCH2CH2)3N.6(H2O). The compound was determined to crystallize in the trigonal space group P-3c1 with a=8.8706(4) Å, c=26.1580(2) Å, and V (volume)=1783 Å3. The structure consists of sheets of corner sharing Mn(II)O4 and PO4 tetrahedra with layers of (H3NCH2CH2)3N and water molecules in-between. The pronated (H3NCH2CH2)3N molecules provide charge balancing for the inorganic sheets. A network of hydrogen bonds between water molecules and the inorganic sheets holds the structure together.

Abstract: A process for the manufacture of a blocked mercaptosilane comprising: reacting at least one polysulfane-containing organosilicon compound of the general formula: (R13SiG)2Sn (a) in which each R1 is independently methoxy, ethoxy or alkyl of from 1 to about 6 carbon atoms, provided, that at least one R1 group is methoxy or ethoxy, G is an alkylene group of from 1 to about 12 carbon atoms and n is from 2 to about 8, with at least one alkali metal, alkaline earth metal or a basic derivative of an alkali metal or alkaline earth metal to provide the corresponding metal salt of the polysulfane-containing organosilicon compound and; (b) reacting the metal salt of the polysulfane-containing organosilicon compound with an acyl halide or carbonyl dihalide to provide a blocked mercaptosilane.

Abstract: A process for producing a norbornene derivative having an organosilyl group suitable as a synthetic intermediate for pesticides and medicaments and for production of polyolefin polymers, particularly polyolefin polymers having a good adhesiveness with metals or insulating inorganic materials in high yields with a satisfactory purity. A process for producing a norbornene derivative having an organosilyl group represented by the general formula (3): wherein R each represents an alkyl group or an aryl group, R′ represents an alkyl group or an aryl group, n represents an integer of 0 to 2 and m represents an integer of 0 or more, which comprises reacting a compound represented by the general formula (1): wherein R, n and m have the same meanings as above, and X represents a halogen atom, with a Grignard agent represented by the general formula (2): R′MgCl  (2) wherein R′ has the same meaning as above.

Abstract: A catalyst comprising a mixed metal oxide is useful for the vapor phase oxidation of an alkane or a mixture of an alkane and an alkene to an unsaturated carboxylic acid and for the vapor phase ammoxidation of an alkane or a mixture of an alkane and an alkene to an unsaturated nitrile.

Abstract: Compounds characterized generally as propargyl glycine amino propargyl diol derivatives are useful for treatment of renal failure.

Abstract: A method has been developed for the preparation of ceralure B1, a potent attractant for the Mediterranean fruit fly. The method utilizes trans-siglure acid as starting material to produce iodolactone which is subsequently reduced to lactone. The lactone is converted to a mixture of epimers ceralure A acid and ceralure B1 acid. The ceralure A acid is recyclized to lactone, leaving epimer ceralure B1 acid intact. Following separation from lactone, the ceralure B1 acid is esterified to produce ceralure B1 of about 92-94% purity. The overall yield is about 58-65%, a significant improvement over currently known methods which result in yields of about 30-33%.

Abstract: Compounds of formula I in the form of their racemates or enantiomers, preferably compounds of formula Ia wherein R4 is C1-C6alkyl, Z is chlorine, bromine or iodine, and X is —OH, chloride, bromide or iodide, or X forms an ester group with the carbonyl substituent, as well as salts of carboxylic acids. The compounds are valuable intermediates for the propagation of &dgr;-amino-&ggr;-hydroxy-&ohgr;-aryl-alkanecarboxamides, which exhibit renin-inhibiting properties and could be used as antihypertensive agents in pharmaceutical preparations.

Abstract: A process for preparing a compound of the formula comprising reacting a compound of the formula wherein R3 is nitro or halo, or a salt thereof, with a compound of the formula R1SX (III) wherein X is hydrogen or alkali metal.

Abstract: The present invention relates to production of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid useful as an intermediate for pharmaceutical products, by an industrial means, economically, safely in a good yield. Novel 2-(2′-cyclohexen-1′-yl)-2-hydroxy-2-phenylacetic acid ester obtained by reacting cyclohexene and benzoylformic acid ester in the presence of a Lewis acid is hydrolyzed and reduced to give 2-cyclohexyl-2-hydroxy-2-phenylacetic acid.

Abstract: Amide, sulfonamide and urea compounds having an inhibitory effect on Src kinase including enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates of said compound, said compound having the general structure shown in Formulae I and II:

Abstract: The benzophenone derivative of combretastatin A-1, designated “hydroxyphenstatin”, was synthesized by compiling a protected bromobenzene and a benzaldehyde to form a benzhydrol which was subsequently oxidized to the ketone. Hydroxyphenstatin was converted to a sodium phosphate prodrug by dibenzyl phosphite phosphorylation and subsequent benzyl cleavage: Hydroxyphenstatin and the prodrugs thereof were found to be a potent inhibitor of tubulin polymerization and to demonstrate surprisingly effective antineoplastic activity against a series of human cancer cells and murine P388 lymphocytic leukemia cells.

Abstract: A hydroformylation process is provided that involves reacting a compound having at least one olefinic carbon-to-carbon bond with hydrogen and carbon monoxide in the presence of a cobalt catalyst and a sulfur-containing additive which suppresses the formation of cobalt carbide in the reaction mixture.

Abstract: The present invention is concerned with novel processes for the preparation of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

Abstract: A subject of the invention is a method for transformation of polyolefin wastes into hydrocarbons and a plant for carrying thereof. According to the method, disintegrated polyolefin raw material is subjected in a reactor to the progressive heating to the temperature below 600° C. together with a catalyst chosen from a group comprising cements, heavy metal silicates and resinates and mixtures thereof, where a catalyst is used in an amount below 30% b.w., preferably in an amount of 5-10 % b.w., calculated on the weight of the polyolefin raw material.

Abstract: A C3 to C6 hydrogen cut from a cracking unit is processed for the conversion of olefins to propylene and hexene via autometathesis. The autometathesis of a mixed normal butenes feed in the presence of a metathesis catalyst operates without any ethylene in the feed mix to the metathesis reactor. Some fraction of the 2-butene feed may be isomerized to 1-butene and the 1-butene formed plus the 1-butene in the feed react rapidly with the 2-butene to form propylene and 2-pentene. The feed to the reactor also includes the recycle of the 2-pentene formed in the reactor with unreacted butenes to simultaneously form additional propylene and hexene. In one embodiment, some or all of the 3-hexene formed in the reaction is isomerized to 1-hexene. In another embodiment, some portion of the 3-hexene produced in the main metathesis reaction is reacted with ethylene to produce 1-butene without the need for superfractionation.

Abstract: There is provided a substantially binder-free catalytic molecular sieve which has been modified by being ex situ selectivated with a silicon compound. The ex situ selectivation involves exposing the molecular sieve to at least two silicon impregnation sequences, each sequence comprising an impregnation with a silicon compound followed by calcination. The catalyst may be used in a hydrocarbon conversion process, such as toluene disproportionation.

Abstract: A process for producing a linear &agr;-olefin which comprises: reacting a stoichiometric excess of a terminal Cn olefin with ethylene in the presence of an organometallic catalyst to produce a Cn+2 linear &agr;-olefin, wherein the catalyst is capable of producing a Schulz-Flory distribution of the linear &agr;-olefin with a Schulz-Flory constant of less than about 0.8 and wherein n is an integer between about 3 to 20.

Abstract: The present invention is directed to a process for handling and/or disposing catalyst fines produced in an oxygenate-to-olefins reactor. The process enhances the way catalyst fines are separated from the liquid fraction by use of a flocculent.

Abstract: A solvent extraction process for the separation recovery of TNT and RDX from Composition B-containing munitions. The munitions also contain liner materials, such as asphalt and binders, and sealers, such as wax, each of which are also recovered by use of solvent technology.

Abstract: The present invention relates to a method of preparing transformed plant cells which are resistant to infection by a Geminivirus, comprising transforming said plant cells with a DNA construct comprising a polynucleotide that encodes a plant or yeast SNF-1 protein kinase and is operably linked to a promoter, and expressing said SNF-1 protein kinase in said plant cells. Also disclosed is a method for conferring viral resistance to plants, comprising regenerating the transformed plant cells to produce transgenic plants that express the SNF-1 kinase and are resistant to infection by Geminivirus.

Abstract: The invention relates to methods for producing transgenic cereal plants resistant to Barley Yellow Dwarf Virus, particularly in the presence of co-infecting Cereal Yellow Dwarf Virus, by stably integrating into the cells of the transgenic plant a chimeric gene comprising a DNA region operably linked to plant expressible promoter in such a way that the RNA molecule may be transcribed from the DNA region, the RNA molecule comprising both sense and antisense RNA capable of pairing and forming a double stranded RNA molecule or hairpin RNA.

Abstract: This invention relates to a reproducible system for the production of stable, genetically transformed maize cells, and to methods of selecting cells that have been transformed. One method of selection disclosed employs the Streptomyces bar gene introduced by microprojectile bombardment into embryogenic maize cells which were grown in suspension cultures, followed by exposure to the herbicide bialaphos. The methods of achieving stablefs transformation disclosed herein include tissue culture methods and media, methods for the bombardment of recipient cells with the desired transforming DNA, and methods of growing fertile plants from the transformed cells. This invention also relates to the transformed cells and seeds and to the fertile plants grown from the transformed cells and to their pollen.

Abstract: The invention provides isolated nucleic acids and their encoded proteins that are involved in cell cycle regulation. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention provides methods and compositions relating to altering cell cycle protein content, cell cycle progression and/or composition of plants.

Abstract: Novel methods for the expression of non-native genes in flax seeds and the seeds of other plant species are provided. The methods involve the use of seed-specific promoters obtained from flax. Additionally provided are novel flax seed-specific promoters, chimeric nucleic acid constructs comprising novel flax seed-specific promoters, transgenic plant cells, transgenic plants and transgenic plant seeds containing novel flax seed-specific promoters. The promoters and methods are useful, for example, for altering the seed oil and protein composition in flax seed or other plant seeds.

Abstract: This invention relates to an isolated nucleic acid fragment encoding a defensin which shares a high degree of sequence identity with the disclosed sequences from Scolopendra canidens, Vaejovis carolinianus, and Argiope spp. The invention also relates to the construction of a chimeric gene encoding all or a portion of the defensin, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the defensin in a transformed host cell.

Abstract: A novel soybean cultivar, designated 0322579, is disclosed. The invention relates to the seeds of soybean cultivar 0322579, to the plants of soybean 0322579 and to methods for producing a soybean plant produced by crossing the cultivar 0322579 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar 0322579 with another soybean cultivar.

Abstract: A novel soybean cultivar, designated S010350, is disclosed. The invention relates to the seeds of soybean cultivar S010350, to the plants of soybean S010350 and to methods for producing a soybean plant produced by crossing the cultivar S010350 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar S010350 with another soybean cultivar.

Abstract: A novel soybean cultivar, designated 0332129, is disclosed. The invention relates to the seeds of soybean cultivar 0332129, to the plants of soybean 0332129 and to methods for producing a soybean plant produced by crossing the cultivar 0332129 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar 0332129 with another soybean cultivar.

Abstract: According to the invention, there is provided a hybrid maize plant, designated as 38A24, produced by crossing two Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. This invention relates to the hybrid seed 38A24, the hybrid plant produced from the seed, and variants, mutants, and trivial modifications of hybrid 38A24. This invention also relates to methods for producing a maize plant containing in its genetic material one or more transgenes and to the transgenic maize plants produced by that method. This invention further relates to methods for producing maize lines derived from hybrid maize line 38A24 and to the maize lines derived by the use of those methods.

Abstract: According to the invention, there is provided a hybrid maize plant, designated as 31R88, produced by crossing two Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. This invention relates to the hybrid seed 31R88, the hybrid plant produced from the seed, and variants, mutants, and trivial modifications of hybrid 31R88. This invention also relates to methods for producing a maize plant containing in its genetic material one or more transgenes and to the transgenic maize plants produced by that method. This invention further relates to methods for producing maize lines derived from hybrid maize line 31R88 and to the maize lines derived by the use of those methods.

Abstract: According to the invention, there is provided a hybrid maize plant, designated as 38J54, produced by crossing two Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. This invention relates to the hybrid seed 38J54, the hybrid plant produced from the seed, and variants, mutants, and trivial modifications of hybrid 38J54. This invention also relates to methods for producing a maize plant containing in its genetic material one or more transgenes and to the transgenic maize plants produced by that method. This invention further relates to methods for producing maize lines derived from hybrid maize line 38J54 and to the maize lines derived by the use of those methods.