Patents Issued in September 14, 2004
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Patent number: 6790564Abstract: In the step of manufacturing a photomask, an opaque pattern is formed by using a photosensitive resin composition containing a specified light absorbent, which then used to manufacture a photomask for KrF excimer laser lithography in a short manufacturing time and at a reduced cost. Accordingly, the manufacturing time and the cost for semiconductor integrated circuit devices is reduced.Type: GrantFiled: December 19, 2001Date of Patent: September 14, 2004Assignee: Renesas Technology CorporationInventors: Sonoko Migitaka, Tadashi Arai, Tsutomu Araki, Satoshi Momose, Osamu Yamaguchi
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Patent number: 6790568Abstract: The present invention provides a photosensitive transfer material comprising a temporary support, a peelable layer, an alkali-soluble thermoplastic resin layer, an intermediate layer and a photosensitive resin layer that are disposed in this order, wherein the bonding strength between the peelable layer and the thermoplastic resin layer is the smallest of all the bonding strengths between neighboring layers.Type: GrantFiled: January 23, 2003Date of Patent: September 14, 2004Assignee: Fuji Photo Film Co., Ltd.Inventor: Hidenori Goto
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Patent number: 6790569Abstract: A color photothermographic element comprising at least three light-sensitive units which have their individual sensitivities in different wavelength regions, each of the units comprising at least one light-sensitive silver-halide emulsion, binder, and dye-providing coupler, and a blocked developer in the presence of a thermal solvent represented by the following structure: wherein the groups are as defined in the specification to promote the thermal development of the photothermographic element.Type: GrantFiled: May 16, 2001Date of Patent: September 14, 2004Assignee: Eastman Kodak CompanyInventors: Xiqiang Yang, Zbyslaw R. Owczarczyk, David T. Southby, Mark E. Irving, Paul B. Merkel, Lyn M. Irving, David H. Levy
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Patent number: 6790570Abstract: A method of using scatterometric techniques to control stepper process is disclosed. In one illustrative embodiment, the method comprises providing a library of optical characteristic traces, each of which corresponds to a grating structure comprised of a plurality of features having a known profile, and forming a plurality of grating structures in a layer of photoresist, each of said formed grating structures being comprised of a plurality of features having an unknown profile.Type: GrantFiled: November 8, 2001Date of Patent: September 14, 2004Assignee: Advanced Micro Devices, Inc.Inventors: James Broc Stirton, Richard D. Edwards, Christopher A. Bode
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Patent number: 6790571Abstract: An electrophotographic photoconductor has an electroconductive support, and a photoconductive layer formed thereon containing as an effective component an aromatic polycarbonate resin having a structural unit of formula (2) and a structural unit with charge transporting properties, each of the structural units being contained in an amount of 5 wt. % or more of the total weight of the polycarbonate resin. There is disclosed an aromatic polycarbonate resin having a structural unit of formula (1) and the structural unit of formula (2), with the relationship between the composition ratios being 0<k/(k+j)<1 when the composition ratio of the structural unit (1) is k and that of the structural unit (2) is j, or an aromatic polycarbonate resin having a repeat unit of formula (3). The formulas (1) to (3) are specified in the specification.Type: GrantFiled: January 22, 2002Date of Patent: September 14, 2004Assignee: Ricoh Company, Ltd.Inventors: Shinichi Kawamura, Masaomi Sasaki, Kazukiyo Nagai, Kohkoku Ri, Susumu Suzuka, Katsuhiro Morooka
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Patent number: 6790572Abstract: An electrophotographic photoreceptor including an electroconductive substrate, a photosensitive layer located overlying the electroconductive substrate, and optionally a protective layer overlying the photosensitive layer, wherein an outermost layer of the photoreceptor includes a filler, a binder resin and an organic compound having an acid value of from 10 to 700 mgKOH/g. The photosensitive layer can be the outermost layer. A coating liquid for an outermost layer of a photoreceptor including a filler, a binder resin, an organic compound having an acid value of from 10 to 700 mgKOH/g and plural organic solvents. A method for preparing a photoreceptor including forming a photosensitive layer, and coating the coating liquid on the photosensitive layer. An image forming method and apparatus and a process cartridge using the photoreceptor are also provided.Type: GrantFiled: November 2, 2001Date of Patent: September 14, 2004Assignee: Ricoh Company LimitedInventors: Nozomu Tamoto, Tetsuro Suzuki, Hiroshi Tamura, Tatsuya Niimi, Akihiko Matsuyama, Eiji Kurimoto, Hidetoshi Kami
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Patent number: 6790573Abstract: An imaging member including at least a support, a charge blocking layer, a charge imaging layer, and an interfacial adhesive layer including at least a copolyester-polycarbonate resin. A process for fabricating the imaging member is also disclosed.Type: GrantFiled: January 25, 2002Date of Patent: September 14, 2004Assignee: Xerox CorporationInventors: Stephan V. Drappel, Kathleen M. Carmichael, David J. Maty, John A. Bergfjord, Sr.
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Patent number: 6790574Abstract: An electrophotographic photoreceptor having a photosensitive layer containing, as a charge transporting material, at least one indane compound of the formula (1), and at least one polycarbonate resin of the formula (4) and/or an organic additive containing at least one atom selected from the group consisting of nitrogen, oxygen, phosphorus and sulfur for an electrophotographic photoreceptor.Type: GrantFiled: September 26, 2002Date of Patent: September 14, 2004Assignee: Hodogaya Chemical Co., Ltd.Inventors: Katsumi Abe, Chieko Inayoshi, Masaki Ohkubo, Mitsutoshi Anzai, Yasuo Murakami
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Patent number: 6790575Abstract: A two component developer comprising a magnetic toner containing a binder resin and a magnetic particle, and a magnetic carrier containing a magnetic particle, wherein the magnetic toner has an average particle diameter of 4.0 to 10.0 &mgr;m, and contains 5 to 80 No. % of toner particles having particle diameter of 5 &mgr;m or less, and exhibits magnetization of 10 to 25 emu/g under magnetic field of 5 kiloersteds.Type: GrantFiled: March 21, 2002Date of Patent: September 14, 2004Assignee: Ricoh Company, Ltd.Inventors: Fumihiro Sasaki, Hiroaki Matsuda, Bing Shu, Maiko Kondo, Hiroshi Nakai, Hiroto Higuchi, Yasuaki Iwamoto, Yoshihiro Suguro, Hiroyuki Yoshikawa, Masahide Yamashita, Kazuyuki Yazaki
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Patent number: 6790576Abstract: It is an object of the present invention to provide a dispersing agent for a pigment capable of finely dispersing a pigment in a dispersion medium. The present invention provides a dispersing agent for a pigment comprising at least a metallic compound having a specific structure with a central metal capable of taking a penta-coordinated structure, and n-electron-donating compound having affinity for the dispersion medium and capable of being coordinated with the central metal of the metallic compound.Type: GrantFiled: January 10, 2003Date of Patent: September 14, 2004Assignee: Canon Kabushiki KaishaInventors: Norikazu Fujimoto, Hitoshi Itabashi
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Patent number: 6790577Abstract: A toner for developing an electrostatically charged image, which is constituted with a microcapsule toner particle composed of a core and a shell, the core comprising a colorant and a binder resin containing an olefin copolymer having a cyclic structure, said olefin copolymer having a glass transition temperature ranging from −20° C. to less than 60° C. and a number average molecular weight ranging from 100 to 20,000, and the shell comprising a coating resin for the core, and/or a shell comprising a resin for coating the core containing an olefin copolymer having a cyclic structure, said olelin copolymer having a glass transition temperature ranging from 60° C. to 180° C. and a number average molecular weight ranging from 1,000 to 100,000. Since this toner is excellent in anti-spent toner effect, transfer properties, fixing ability, and offset-free properties, it is applicable to electrostatically charge image type copiers, printers, etc.Type: GrantFiled: November 4, 2002Date of Patent: September 14, 2004Assignee: Ticona GmbHInventor: Toru Nakamura
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Patent number: 6790578Abstract: A weather resistant sign and a method of printing a sign including the steps of providing a sign component and an image definition, applying dry toner powder to surface portions corresponding to the image definition, and fusing the applied toner. Preferably, the fused toner is protected from weather by a transparent protective layer. A toner composition and a computer program for printing are also disclosed.Type: GrantFiled: March 7, 1994Date of Patent: September 14, 2004Assignee: 3M Innovative Properties CompanyInventors: J. Sundar Rajan, Vincent Joseph Mako
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Patent number: 6790579Abstract: The present invention relates to a radiation sensitive photoresist composition comprising a photoacid initiator and a polycyclic polymer comprising repeating units that contain pendant acid labile groups. Upon exposure to an imaging radiation source the photoacid initiator generates an acid which cleaves the pendant acid labile groups effecting a polarity change in the polymer. The polymer is rendered soluble in an aqueous base in the areas exposed to the imaging source.Type: GrantFiled: August 2, 2000Date of Patent: September 14, 2004Assignee: Sumitomo Bakelite Co., Ltd.Inventors: Brian L. Goodall, Saikumar Jayaraman, Robert A. Shick, Larry F. Rhodes
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Patent number: 6790580Abstract: A resist material is made of a polymer or copolymer having a cyclic hydrocarbon as a skeletal structure and an alkali-soluble group to which a protective group is attached as a side chain. Because of the protective group, the resist material is insoluble in alkali solution. In addition, an acid generating agent is added to the resist material. When the acid generating agent is irradiated with a radiation ray, an acid is generated from the acid generating agent, and the protective group is detached from the alkali-soluble group by the function of the acid. Therefore, a resist film made of the resist material can be formed in a desired pattern by irradiating the resist film with the radiation ray.Type: GrantFiled: December 23, 2002Date of Patent: September 14, 2004Assignee: Fujitsu LimitedInventor: Satoshi Takechi
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Patent number: 6790581Abstract: A phenolic resin/silicone resin hybrid compound is obtained by effecting hydrolytic condensation of an organooxysilane in the co-presence of a phenolic resin. The hybrid compound is used as the base polymer in a resist for endowing a resist film with excellent adhesion to a metal substrate.Type: GrantFiled: October 11, 2002Date of Patent: September 14, 2004Assignee: Shin-Etsu Chemical Company, LimitedInventors: Hideto Kato, Tomoyoshi Furihata
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Patent number: 6790582Abstract: The present invention relates to a composition and a process for preparing a composition that comprises: a) a novolak resin partially esterified with from about 3 to about 7 weight percent of a naphthoquinonediazidosulfonyl group; b) one or more dilution resins; and c) at least one solvent.Type: GrantFiled: April 1, 2003Date of Patent: September 14, 2004Assignee: Clariant Finance BVI LimitedInventor: J. Neville Eilbeck
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Patent number: 6790583Abstract: A method of producing a light absorbing pattern film coated article with a transmitted light spectrum distribution corresponding to the pattern of a photomask, wherein a light absorbing film coating solution, containing a silicon oxide raw material, a titanium oxide raw material, which contains titanium oxide microparticles, and a gold microparticle raw material, is coated onto the surface of a substrate, the photomask is positioned on top of said coated film, ultraviolet light is irradiated onto said coated film, and said coated film is thereafter heated. By the abovementioned method of producing, this invention can provide light absorbing film coated articles with various transmitted light spectra distribution while keeping the visible light reflectivity low.Type: GrantFiled: June 22, 2001Date of Patent: September 14, 2004Assignee: Nippon Sheet Glass Co., Ltd.Inventor: Mitsuhiro Kawazu
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Patent number: 6790584Abstract: A silver halide photographic light-sensitive material having layers containing a swellable inorganic stratifying compound on both sides of a support and having at least one silver halide emulsion layer on at least one of the layers. There is provided a silver halide photographic light-sensitive material showing good dimensional stability.Type: GrantFiled: March 21, 2003Date of Patent: September 14, 2004Assignee: Fuji Photo Film Co., Ltd.Inventors: Tadashi Ito, Toshiaki Kubo
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Patent number: 6790585Abstract: The present invention relates to a method for developing an exposed high contrast photographic silver halide material, said photographic material comprising a support bearing at least one silver halide emulsion layer, containing at least one hydrazide nucleating agent. According to the invention, the nucleating agent has the formula (I) and the photographic material is developed in a hydroquinone-free developer, comprising a main developing agent of the ascorbic acid or ascorbic acid salt type, and as auxiliary developing agent a mixture of 3-pyrazolidones of which at least one has the formula (II): wherein at least one of the radicals R3 to R9 contains a solubilizing group. This combination enables photographic materials with ultrahigh contrast to be obtained.Type: GrantFiled: June 19, 2003Date of Patent: September 14, 2004Assignee: Eastman Kodak CompanyInventors: Jacques Roussilhe, Siu C. Tsoi, John D. Goddard, Llewellyn J. Leyshon
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Patent number: 6790586Abstract: A resist composition comprising (A) a polymer comprising recurring units having an alicyclic hydrocarbon backbone to which a carboxylate moiety capable of generating carboxylic acid when decomposed under acidic conditions is attached through a C1-C20 alkylene spacer, (B) a photoacid generator, and (C) an organic solvent is sensitive to high-energy radiation, and has excellent sensitivity and resolution at a wavelength below 180 nm, and good plasma etching resistance. Because these features of the inventive resist composition enable its use particularly as a resist at the exposure wavelength of a F2 excimer laser, a finely defined pattern can easily be formed, making the resist ideal as a micropatterning material in VLSI fabrication.Type: GrantFiled: September 7, 2001Date of Patent: September 14, 2004Assignees: Shin-Etsu Chemical Co., Ltd., Matsushita Electric Industrial Co., Ltd., Central Glass Co., Ltd.Inventors: Jun Hatakeyama, Yuji Harada, Jun Watanabe, Yoshio Kawai, Masaru Sasago, Masayuki Endo, Shinji Kishimura, Michitaka Ootani, Satoru Miyazawa, Kentaro Tsutsumi, Kazuhiko Maeda
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Patent number: 6790587Abstract: Fluorinated polymers, photoresists and associated processes for microlithography are described. These polymers and photoresists are comprised of a fluoroalcohol functional group which simultaneously imparts high ultraviolet (UV) transparency and developability in basic media to these materials. The materials of this invention have high UV transparecy, particularly at short wavelengths, e.g., 157 nm, which makes them highly useful for lithography at these short wavelengths.Type: GrantFiled: October 17, 2001Date of Patent: September 14, 2004Assignee: E. I. du Pont de Nemours and CompanyInventors: Andrew Edward Feiring, Jerald Feldman, Frank Leonard Schadt, III
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Patent number: 6790588Abstract: Disclosed is a thermally sensitive imagable article and compositions therefor. The imagable article comprises a coating on a substrate, the coating comprising an amino acid or amide, and a compound capable of generating an acid upon heating. The coating optionally comprises a radiation absorbing compound. When imagewise exposed the coating has the property that exposed regions become relatively insoluble in a developer liquid whereas regions that have not been exposed remain relatively soluble in the developer and dissolve in the developer, leaving the exposed substrate in those regions.Type: GrantFiled: December 10, 2001Date of Patent: September 14, 2004Assignee: Kodak Polychrome Graphics LLCInventors: Gregory Turner, Denise Howard
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Patent number: 6790589Abstract: A radiation sensitive material comprising a copolymer including itaconic anhydride and methods of using such radiation sensitive materials in methods for forming a pattern.Type: GrantFiled: December 21, 2001Date of Patent: September 14, 2004Assignee: Fujitsu LimitedInventors: Satoshi Takechi, Makoto Takahashi, Yuko Kaimoto
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Patent number: 6790590Abstract: Infrared absorbing compounds in which both the anion and the cation absorb infrared radiation, imageable elements that contain these compounds, and methods for forming images using the imageable elements are disclosed. The compounds have the structure: in which Y1 and Y2 are each independently hydrogen, halo, alkyl, diphenylamino, or phenylthio; R1, R2, R3, and R4 are each independently hydrogen, methyl, or SO3−, with the proviso that two of R1, R2, R3, and R4 are SO3−; R5 and R6 are each independently an alkyl group; Z1, Z2, Z4, and Z5 are each independently a benzo group or a naphtho group; Z3 and Z6 are each independently two hydrogen atoms, a cyclohexene residue, or a cyclopentene residue; X1, X2, X3, and X4 are each independently S, O, NH, CH2, or C(CH3)2; and n1 and n2 are each independently 0 to 4.Type: GrantFiled: January 27, 2003Date of Patent: September 14, 2004Assignee: Kodak Polychrome Graphics, LLPInventors: Jeffrey Collins, Ting Tao, Thomas Jordan
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Patent number: 6790591Abstract: A resist composition comprising a fluorinated polymer having carboxylate pendants and with a weight average molecular weight of 1,000-500,000 as a base resin is sensitive to high-energy radiation below 200 nm, has high transparency, resolution and plasma etching resistance, and is suited for lithographic microprocessing.Type: GrantFiled: April 4, 2003Date of Patent: September 14, 2004Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Yuji Harada, Jun Hatakeyama, Yoshio Kawai
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Patent number: 6790592Abstract: A phase-change optical information recording medium capable of recording information therein, reproducing recorded information therefrom, rewriting recorded information, and erasing recorded information therefrom, which phase-change optical information recording medium is provided with a recording layer containing therein a phase-change recording material including Ge, Ga, Sb, Te, and one element selected from the group consisting of Mg and Ca, which recording material is capable of performing a reversible phase transition from a noncrystalline phase to a crystalline phase and vice verse with the application of an electromagnetic wave thereto.Type: GrantFiled: September 14, 2001Date of Patent: September 14, 2004Assignee: Ricoh Company, Ltd.Inventors: Makoto Harigaya, Katsuhiko Tani, Noriyuki Iwata, Kazunori Ito, Hajime Yuzurihara, Eiko Hibino, Hiroko Ohkura, Nobuaki Onagi, Hiroshi Miura, Yoshiyuki Kageyama
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Patent number: 6790593Abstract: There was found a metallocenyl-phthalocyanine or its metal complex of a divalent metal, oxometal, halogenometal or hydroxymetal, in which at least one of the four phenyl rings of the phthalocyanine contains, bound via a bridge unit E, at least one metallocene radical as substituent, E being composed of a chain of at least two atoms or atom groups selected from the group consisting of —CH2—, —C(═O)—, —CH(C1-C4alkyl)—, —C(C1-C4alkyl)2—, —NH—, —S—, —O— and —CH═CH—, as well as mixtures of the novel compounds which comprise, inter alia, isomers, a process for the production, the use and recording media comprising the novel compounds.Type: GrantFiled: October 22, 2001Date of Patent: September 14, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Heinz Wolleb, Annemarie Wolleb, Beat Schmidhalter, Jean-Luc Budry
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Patent number: 6790594Abstract: Making a high absorption donor substrate for providing one or more OLED materials to an OLED device by: providing an absorber anti-reflection layer over a transparent support element, the anti-reflection layer having the real portion of its index of refraction greater than 3.0, and a thickness near the first reflectivity minimum at the wavelength of interest; providing a metallic heat-absorbing layer over the anti-reflection layer for absorbing laser light which passes through the transparent support element and the anti-reflection layer; and selecting the transparent support element, the anti-reflection layer, and the metallic heat-absorbing layer to have an average reflectivity of less than 10%, and the micro reflectivity variation due to variations in the thickness of the transparent support element of less than 10% at the wavelength of interest; and providing one or more organic material layers in the absence of a binder material, over the metallic heat-absorbing layer.Type: GrantFiled: March 20, 2003Date of Patent: September 14, 2004Assignee: Eastman Kodak CompanyInventors: Donald R. Preuss, Fridrich Vazan
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Patent number: 6790595Abstract: A negative-working heat-sensitive material for making a lithographic printing plate by direct-to-plate recording is disclosed. The material comprises in the order given a lithographic base having a hydrophilic surface, an oleophilic imaging layer and a cross-linked hydrophilic upper layer which comprises an organic compound derived from sulfonic acid, sulfuric acid, phosphoric acid or phosphonic acid. Materials according to the invention are characterized by an increased water-acceptance in the non-printing areas, which allows a rapid start-up of the press.Type: GrantFiled: November 2, 2001Date of Patent: September 14, 2004Assignee: Agfa-GevaertInventors: Marc Van Damme, Wim Sap, Huub Van Aert
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Patent number: 6790596Abstract: A photoreactive resin composition having high sensitivity and causing less gelation, and methods of manufacturing a circuit board and a ceramic multilayer substrate having a high-resolution wiring pattern and via holes by a photolithography process using the photoreactive resin composition are described. The photoreactive resin composition contains an inorganic powder containing a polyvalent metal powder and/or a polyvalent metal oxide powder, an alkali-soluble first polymer having an ethylenically unsaturated double bond, a monomer having an ethylenically unsaturated double bond, a photoreaction initiator, an organic solvent, and a second polymer having a pyrrolidone ring in a side chain.Type: GrantFiled: October 11, 2002Date of Patent: September 14, 2004Assignee: Murata Manufacturing Co., LtdInventors: Masahiro Kubota, Michiaki Iha, Shizuharu Waatanabe
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Patent number: 6790597Abstract: In accordance with the present invention, there are provided novel thermosetting resin compositions which do not require solvent to provide a system having suitable viscosity for convenient handling. Invention compositions have the benefit of undergoing rapid cure. The resulting thermosets are stable to elevated temperatures, are highly flexible, have low moisture uptake and are consequently useful in a variety of applications, e.g., in adhesive applications since they display good adhesion to both the substrate and the device attached thereto.Type: GrantFiled: August 1, 2002Date of Patent: September 14, 2004Assignee: Henkel CorporationInventors: Stephen M. Dershem, Dennis B. Patterson, Jose A. Osuna, Jr.
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Patent number: 6790598Abstract: Methods of patterning resists and structures including the patterned resists are disclosed. A patterned, multi-transmissive mask is used during patterning of resists to control exposure at areas of the resist at which features having different detail are desired. Exposure is varied in more finely patterned and more grossly patterned areas of the resist. The patterned resists have a high degree of topographical uniformity.Type: GrantFiled: January 16, 2002Date of Patent: September 14, 2004Assignee: Xerox CorporationInventors: Cathie J. Burke, Diane Atkinson, Mildred Calistri-Yeh
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Patent number: 6790599Abstract: Planar microfluidic devices are laminate structures having a matrix layer at an upper side laminated at an interface to a lower substrate layer. The structure has one or more cavities extending from the upper side to the interface. A membrane is laminated on the upper side of the structure thereby to form a fluid barrier for the cavities. Devices for use as electrochemical sensors further include an electrode at the laminate structure interface below the matrix layer cavity and a well through the substrate layer below the electrode for electrical communication.Type: GrantFiled: July 13, 2000Date of Patent: September 14, 2004Assignee: Microbionics, Inc.Inventor: Marc J. Madou
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Patent number: 6790600Abstract: A method of processing photographic color papers is carried out using a photographic bleach-fixing composition in a bleach-fixing step that is carried out for less than 60 seconds. The bleach-fixing composition comprises certain aliphatic or aromatic sulfur-containing compounds that include a —N═C(SH)—group. The bleach-fixing composition can be prepared from a two-part bleach-fixing kit having two solutions that can be added directly to a processing chamber or premixed to form a replenisher solution.Type: GrantFiled: February 7, 2003Date of Patent: September 14, 2004Assignee: Eastman Kodak CompanyInventors: Paul A. Schwartz, Valerie L. Kuykendall, Eric R. Schmittou, Leif P. Olson, Susan M. Flavin
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Patent number: 6790602Abstract: This invention relates to a method of spectrally sensitizing a silver halide emulsion comprising the following steps in the following order a) providing a silver halide emulsion comprising tabular silver halide grains having an inner dye layer adjacent to the silver halide grain, said dye layer comprising at least one dye (Dye 1) that is capable of spectrally sensitizing silver halide, b) adding to the emulsion at least one dye (Dye 2) capable of providing a second dye layer adjacent to the inner dye layer, and c) adding to the emulsion a non-cationic surfactant or a scavenger for oxidized developer, or a combination of the two, to form a silver halide emulsion comprising silver halide grains having associated therewith two dye layers, wherein the dye layers are held together by non-covalent forces or by in situ bond formation; the outer dye layer adsorbs light at equal or higher energy than the inner dye layer; and the energy emission wavelength of the outer dye layer overlaps with the energy absorptionType: GrantFiled: January 17, 2003Date of Patent: September 14, 2004Assignee: Eastman Kodak CompanyInventors: David R. Foster, Stephen P. Singer, William J. Harrison, Alan R. Pitt
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Patent number: 6790603Abstract: Blood platelets stored in an isotonic, balanced salt solution under standard storage conditions retain function after ten days of storage when micormolar or nanomolar amounts of pentose are added to the solution. The preferred pentoses are D-Ribose, xylulose-5-phosphate and the pentose-related alcohol xylitol.Type: GrantFiled: December 21, 2000Date of Patent: September 14, 2004Assignee: Bioenergy, Inc.Inventors: Daniel G. Ericson, John St. Cyr
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Patent number: 6790604Abstract: A method of predicting the lymphotropic metastatic potential of a solid non-lymphoid tumor. The percentage of cells of each of a plurality of representative samples of the tumor which express lymphoid gene products is determined. The metastatic potential is predicted to be low when no tumor cells in all of the samples are detected to express lymphoid gene products. The metastatic potential is predicted to be high when a high percentage of tumor cells in at least one of the samples are detected to express lymphoid gene products. A solid non-lymphoid tumor is treated by systemically administering a substance comprising a therapeutically effective amount of a molecule linked to a toxin, radionuclide, or chemotherapeutic agent and having binding specificity for a tumor specific lymphoid gene product idiotype.Type: GrantFiled: May 12, 1998Date of Patent: September 14, 2004Inventors: Stefan A. Cohen, Untae Kim, David P. Montesanti
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Patent number: 6790605Abstract: Disclosed is a process for obtaining an enzyme having a specified enzyme activity derived from a heterogeneous DNA population by screening, for the specified enzyme activity, a library of clones containing DNA from the heterogeneous DNA population which have been exposed to directed mutagenesis towards production of the specified enzyme activity. Also disclosed is a process for obtaining an enzyme having a specified enzyme activity by screening, for the specified enzyme activity, a library of clones containing DNA from a pool of DNA populations which have been exposed to directed mutagenesis in an attempt to produce in the library of clones DNA encoding an enzyme having one or more desired characteristics which can be the same or different from the specified enzyme activity.Type: GrantFiled: August 17, 1999Date of Patent: September 14, 2004Assignee: Diversa CorporationInventor: Jay M. Short
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Patent number: 6790606Abstract: Polynucleotides encoding mammalian ECM signaling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis, chondrogenesis, and oncogenesis, are provided. The polynucleotide compositions include DNAs and RNAs comprising part, or all, of an ECM signaling molecule coding sequence, or biological equivalents. Polypeptide compositions are also provided. The polypeptide compositions comprise mammalian ECM signaling molecules, peptide fragments, inhibitory peptides capable of interacting with receptors for ECM signaling molecules, and antibody products recognizing Cyr61. Also provided are methods for producing mammalian ECM signaling molecules. Further provided are methods for using mammalian ECM signaling molecules to screen for, and/or modulate, disorders associated with angiogenesis, chondrogenesis, and oncogenesis; ex vivo methods for using mammalian ECM signaling molecules to prepare blood products are also provided.Type: GrantFiled: January 31, 2000Date of Patent: September 14, 2004Assignee: Munin CorporationInventor: Lester F. Lau
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Patent number: 6790607Abstract: A method for detecting interactions between first and second interacting molecules at variable sensitivity. This variable sensitivity may be obtained by providing for the overexpression of either a bait hybrid protein containing a DNA binding domain (desensitization) or a prey hybrid protein containing the DNA activation domain for a reporter gene (enhanced sensitivity). The use of exogenous activators of one or the other according to the needs of a particular system is readily accomplished.Type: GrantFiled: October 6, 2000Date of Patent: September 14, 2004Assignee: Hybrigen, Inc.Inventors: David N. Edwards, Arlene Leon, David F. Ranney
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Patent number: 6790608Abstract: The present invention provides an isolated nucleic acid molecule containing a nucleotide sequence which encodes an ADP-glucose receptor, and isolated polynucleotides therefrom. Also provided is an isolated ADP-glucose receptor polypeptide, an isolated immunogenic peptide therefrom, and antibodies specific therefor. The invention also provides a method of identifying an ADP-glucose receptor agonist or antagonist, by contacting an ADP-glucose receptor with one or more candidate compounds under conditions suitable for detection of a G-protein coupled signal in response to ADP-glucose, and identifying a candidate compound that alters production of the signal. Further provided is a method of identifying an ADP-glucose receptor ligand, by contacting an ADP-glucose receptor with one or more candidate compounds under conditions suitable for detecting selective binding of ADP-glucose to ADP-glucose receptor, and identifying a candidate compound that selectively binds the ADP-glucose receptor.Type: GrantFiled: February 9, 2001Date of Patent: September 14, 2004Assignee: The Regents of the University of CaliforniaInventors: Olivier Civelli, Hans-Peter Nothacker, Zhiwei Wang, Rainer Reinscheid
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Patent number: 6790609Abstract: A method for measuring a thiol group-containing compound, which comprises the steps of (1) contacting a sample containing a thiol group-containing compound with a thin membrane comprising a microparticle of a substance selected from the group consisting of a metal and a metal compound and comprising a hydrophilic binder; and (2) detecting a color change on the thin membrane resulting from interaction of the thiol group-containing compound and the microparticle, and a thin membrane used for said method. A thiol group containing compound such as an alkylmercaptan or a protein containing thiol groups can be conveniently and accurately measured.Type: GrantFiled: June 7, 2001Date of Patent: September 14, 2004Assignee: Fuji Photo Film Co., Ltd.Inventors: Ryoichi Nemori, Junji Nishigaki, Yutaka Tamura
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Patent number: 6790610Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.Type: GrantFiled: June 27, 2001Date of Patent: September 14, 2004Assignee: Pharmacia & Upjohn CompanyInventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
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Patent number: 6790611Abstract: The present invention relates to a kit and an assay method for rapidly and directly detecting a predetermined respiratory syncytial virus-related biological cell in a sample, even when present in an amount of less than about 2000 cells per microliter. In a preferred embodiment, a labeled antibody targets a nucleoprotein or a glycoprotein of RS virus. One may further detect an inflammatory indicator in the sample.Type: GrantFiled: October 17, 2001Date of Patent: September 14, 2004Assignee: Besst-Test APSInventors: Michael Rud Lassen, Morten Breindahl
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Patent number: 6790612Abstract: A cell-based assay system in which the detection of the reporter gene activity, or secreted alkaline phosphatase (SEAP), is dependent upon the protease activity of the Hepatitis C virus NS3 gene product. This system can be used to assess the activity of candidate protease inhibitors in a mammalian cell-based assay system. The assay system is simpler than previously described assays due to the use of SEAP which allows the reporter gene activity to be quantified by measuring the amount of secreted gene product in the cell media by monitoring the conversion of luminescent or calorimetric alkaline phosphatase substrate.Type: GrantFiled: July 10, 2002Date of Patent: September 14, 2004Assignee: Agouron Pharmaceuticals, Inc.Inventors: Karen Elizabeth Potts, Roberta Lynn Jackson, Amy Karen Patick
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Patent number: 6790613Abstract: This invention relates to the improvement of arrays of porous polymer pads on solid supports used in biological assays. The invention involves freeze drying the porous polymer pads to increase pore size. The increased pore size results in an enhanced ability of the porous polymer pads to bind specific binding substances such as DNA, RNA and polypeptides.Type: GrantFiled: November 12, 1999Date of Patent: September 14, 2004Assignee: Amersham Biosciences ABInventors: Song Shi, George Maracas, Vi-En Choong
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Patent number: 6790614Abstract: The present invention concerns a method of identifying genetically modified mammalian cells using a mutated protein-tyrosine kinase receptor (PTKR) as a selectable marker in mammalian cells. Particularly preferred mutated PTKR selective markers are mutated epidermal growth factor receptor (EGFR) family members, and muscle specific tyrosine kinase receptor (MuSK-R) family members. Further a method for the immunoselection of transduced mammalian cells is disclosed comprising retrovirally transducing mammalian cells with a nucleic acid sequence encoding a mutated EGFR, incubating the transduced cells with a marked antibody which recognizes and binds specifically to the mutated PTKR, and identifying the marked transduced cells.Type: GrantFiled: November 17, 2000Date of Patent: September 14, 2004Assignee: Novartis AGInventors: Susanne Dagmar Pippig, Gabor Veres
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Patent number: 6790615Abstract: Method and compositions for regulating cell cycle progression are disclosed. Compositions include nucleic acids comprising a human Cdc5 gene, antisense gene and fragments thereof and a human Cdc5 protein and polypeptide fragments thereof polypeptide. The consensus DNA binding site for hCdc5 has been described.Type: GrantFiled: January 8, 2001Date of Patent: September 14, 2004Assignee: Regents of the University of CaliforniaInventor: Harold S. Bernstein
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Patent number: 6790616Abstract: This invention provides a method, a kit and a reagent for typing of the HLA class I alleles. Explaining concretely, a single HLA class I antigen or allele is determined by combining PCR amplification using a primer pair which can amplify all HLA-A alleles, all HLA-B alleles or all HLA-C alleles, or which is specific to the common sequence to alleles of the specific group consisting of the specific HLA-A alleles or the specific HLA-B alleles, with reverse hybridization analysis using DNA probes capable of specifically hybridizing with the sequence of al least a specific HLA-A allele, at least a specific HLA-B allele or at least a specific HLA-C allele, which are covalently immobilized on wells of microtiter plates.Type: GrantFiled: May 24, 2001Date of Patent: September 14, 2004Assignee: Shionogi & Co., Ltd.Inventors: Toyoki Moribe, Toshihiko Kaneshige
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Patent number: 6790617Abstract: Genomic DNA region including the about 1.5 kb upstream region of MEGSIN gene was isolated and its nucleotide sequence was determined. In the genomic DNA region, two regulatory sequences that regulate the transcription positively were identified. Furthermore, nucleotide substitutions were introduced in the promoter regions located at the 3′ sites of the two regulatory sequences by site specific mutagenesis, and the nucleotide sequences that play important roles in the promoter activity were successfully identified.Type: GrantFiled: October 16, 2001Date of Patent: September 14, 2004Assignees: Toshio Miyata, Kiyoshi KurokawaInventor: Toshio Miyata