Patents Issued in October 12, 2004
  • Patent number: 6803004
    Abstract: The present invention provides low cost resins (e.g., advanced epoxy resins), processes for making these resins, and coatings made with theses resins. Specifically, the present invention provides high throughput extrusion processing of advanced epoxy resins using an appropriate amount of an iminium salt catalyst. Preferred iminium salt catalysts are stable at room temperature in the reaction mixture (thereby enabling the pre-mixing of ingredients and the stable storage of the pre-mixed ingredients) and yet are highly efficient at the processing temperatures described herein. An example of one such advance epoxy resin is the reaction product of diglycidyl ether of bisphenol A with bisphenol A in the presence of an iminium salt catalyst. Preferred processes are performed using no solvent or only negligible amounts of solvent. One preferred extrusion process utilizes an intermeshing co-rotating twin-screw extruder, however, other types of extruders may alternatively be employed.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: October 12, 2004
    Assignee: Valspar Sourcing, Inc.
    Inventors: Alan Bochan, Thomas R. Mallen, Mike A. Lucarelli
  • Patent number: 6803005
    Abstract: A method for making a multi-layer helmet shell wherein inner and outer, structural, load-bearing semi-rigid layers are spray-deposited onto opposite surfaces of a pre-shaped, pliable viscoelastic, acceleration-rate-sensitive, microcellular foam core.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: October 12, 2004
    Assignee: MJD Innovations, LLC
    Inventors: Mike Dennis, Russell A. Monk
  • Patent number: 6803006
    Abstract: A method for creating a patterned concrete surface with the aid of a concrete surface retarding agent. According to the invention, printing technique or an output technique is used to transfer the surface retarding agent forming the desired pattern to the surface coming into direct contact with the concrete to be cast. The printing or output technique can also be used to transfer a release agent or other substance affecting the surface of the concrete to the surface coming into contact with the concrete to be cast, in the same or in a separate transfer stage.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: October 12, 2004
    Inventor: Janne Samuli Naamanka
  • Patent number: 6803007
    Abstract: A connector element for connecting frame parts at a joint location in a bicycle frame is made of a single part of structural fiber based material, typically carbon fiber material, after reticulation in a mould exploiting the expansion of a core on which windings of fiber fabric material are provided, to obtain the application of a uniform radial pressure on the layers of fiber based material. In one embodiment, the connector element defines a bicycle bottom bracket and tubular extensions departing therefrom for connection to elements of the bicycle frame.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: October 12, 2004
    Assignee: Campagnolo S.r.l.
    Inventor: Mario Meggiolan
  • Patent number: 6803008
    Abstract: This invention provides a method of applying a coating of a resin-rich material to a substrate to produce a molded device. The method involves installing a layer of the resin-rich material over a mold die and adding a molten substrate to melt the resin-rich layer and filling the mold. The mold is cooled and a molded device with a surface containing the resin-rich layer is formed.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: October 12, 2004
    Assignee: Valeo Electrical Systems, Inc.
    Inventor: Harry Charles Buchanan, Jr.
  • Patent number: 6803009
    Abstract: A process for making a necked nonwoven web having improved cross directional uniformity includes the steps of passing a nonwoven web between a first nip having a first surface velocity and a second nip having a second surface velocity, necking the nonwoven web between the first and second nips, and selectively increasing the necking of a central region of the nonwoven web relative to two edge regions or selectively decreasing the necking in the edge regions. The selective increase in necking in the central region or selective decrease in necking in the edge regions offsets the relatively higher necking in the edge regions which is inherent in conventional necking processes. A process for making a laminate having improved cross-directional uniformity is also provided.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: October 12, 2004
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Michael T. Morman, Sjon-Paul L. Conyer, Randall J. Palmer, Charles J. Morell
  • Patent number: 6803010
    Abstract: A method of making a segmented hook and loop type fastener which accommodates molding contours. Several different methods for fabricating such a fastener are disclosed. A plurality of mold plates include a fastener forming zone, having similar arcuate edges. The fastener forming zone further comprises fastening element mold cavities intersecting these edges and one face of the mold plate, the mold cavities being arranged into a plurality of segment forming regions. Circumscribing each of the segment forming regions, is a gasket mold cavity; and between each adjacent pair of segment forming regions, is a hinge forming region. The mold plates form a cylindrical mold wheel having a circular surface formed by the arcuate edges of the mold plates such that the segment forming regions are spaced apart circumferentially around the cylindrical surface. The apparatus further comprises an extruder having a die whose surface is disposed close to the cylindrical surface.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: October 12, 2004
    Assignee: Velcro Industries B.V.
    Inventors: Peter E. Leach, Christopher M. Gallant
  • Patent number: 6803011
    Abstract: A method of making a feedstock for injection molding, including the steps of: mixing at a temperature of at least 100° C. polymeric materials having a thermal conductivity in the range of 0.001 to 0.01 cal/cm-sec-° C. wherein the polymeric materials are selected from the group consisting of polyethylene, polystyrene, polyester, and polycarbonate or combinations thereof, and one or more materials selected from the group consisting of ceramics, ceramic composites, metals and metal alloys in a blended relationship to form a viscous phase mixture, the materials in the viscous phase mixture being selected so that when in a solid phase it has a density greater than 4 grams/cc and a thermal conductivity greater than 0.101 cal/cm-sec-° C. and; cooling the blended viscous phase mixture to form the feedstock.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: October 12, 2004
    Assignee: Eastman Kodak Company
    Inventors: Syamal K. Ghosh, Dilip Chatterjee, Donn B. Carlton
  • Patent number: 6803012
    Abstract: A surface treatment composition of the present invention comprises (A) urethaneacrylate oligomer, (B) acrylate based monomer, (C) photoinitiator; (D) silicon additive, and (E) silica matting agent. The present invention provides a surface treatment composition in which imparts abrasion and scratch resistance to the surface of a soft type urethaneacrylate oligomer decorative floor covering, and ameliorates the problem of low stain resistance caused a low density of elaborate crosslinks by using a small amount of single functional group monomer. The present invention also provides a surface treatment composition in which employs only hard type urethaneacrylate without single functional group monomer so that cross linking density is increased and the effects of oxygen that prohibits the surface curing are minimized, resulting in improved stain resistance.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: October 12, 2004
    Assignee: LG Chem Ltd.
    Inventors: Ho-Zun Park, Min-Ho Son
  • Patent number: 6803013
    Abstract: The present invention relates to an apparatus and method for forming meltblown material with a die assembly. The die may further include a die tip and a heating element positioned relative to the die tip apex to maintain the polymer material extruded from the die tip in a molten state.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: October 12, 2004
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Jeffrey E. Fish, Lamar H. Gipson, Jark C. Lau
  • Patent number: 6803014
    Abstract: The present invention relates to a method for making a heat-resistant elastic article and a heat-resistant elastic article. The invention especially relates to a method of making elastic fibers and polymeric elastic fibers wherein the elastic fibers are capable of withstanding dyeing and heat-setting processes that typically are conducted at elevated temperatures (such as 110-230° C. and especially at greater than or equal to 130° C. for minutes). The inventive method comprises radiation crosslinking an article (or plurality of articles) under an inert or oxygen limited atmosphere (for example, in N2, argon, helium, carbon dioxide, xenon and/or a vacuum) wherein the article (or articles) comprises at least one amine stabilizer and preferably another optional stabilizer additive. More preferably, the radiation crosslinking is performed at a low temperature (−50 to 40° C.).
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: October 12, 2004
    Assignee: Dow Global Technologies Inc.
    Inventors: Thoi H. Ho, Selim Bensason, Rajen M. Patel, Kimberly S. Houchens, Rona L. Reid, Pak-Wing S. Chum, Leonie K. Walsh
  • Patent number: 6803015
    Abstract: A ceramic honeycomb wall-flow filter is prepared by plugging channels in a ceramic honeycomb by a method comprising the following. First, a mixture comprised of a dispersing liquid and ceramic powder is formed. Next, the mixture is inserted on one end of the channel in an unplugged ceramic honeycomb such that the mixture flows to the other end where the mixture collects and forms a plugged ceramic honeycomb. Then, the plugged ceramic honeycomb is heated to a temperature sufficient to sinter the plugged ceramic honeycomb to form a porous sintered plugged ceramic honeycomb.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: October 12, 2004
    Assignee: Dow Global Technologies Inc.
    Inventors: Fredrick W. Vance, Sten A. Wallin
  • Patent number: 6803016
    Abstract: In a device for atomizing and granulating liquid oxidic slags such as, e.g., converter slags, blast furnace slags or waste incineration slags, including a slag tundish having an outlet opening into which a height-adjustable lance for a propellant jet opens and to which a cooling chamber is connected, the outlet opening is surrounded by an immersion tube arranged concentrically therewith while forming an annular gap. A guide body capable of being adjusted in the axial direction of the lance is arranged in the region of the nozzle mouth of the propellant jet lance, which guide body deflects the propellant jet in the radial direction.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: October 12, 2004
    Assignee: Tribovent Verfahrensentwicklung GmbH
    Inventor: Alfred Edlinger
  • Patent number: 6803017
    Abstract: The powder homogenizing apparatus of the invention comprises a cylindrical shell with a circular section and a substantially horizontal axis, an assembly of cylindrical drums disposed inside the shell and comprising an inner drum and an outer drum, the external face of the cylindrical wall of said outer drum being overlaid with blades, which drum assembly can homogenize the powder contained in the annular space formed between the outer drum and the shell, a space of revolution being formed between said inner and outer drums, and a shaft on which said cylindrical drum assembly is mounted in integral manner, said shaft being hollow and connected outside the shell to a cold air supply system and also connected to an air exhaust system outside the shell; drive means for rotating said shaft are also provided.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: October 12, 2004
    Assignee: Compagnie Generale des Matieres Nuclearies
    Inventors: Gérard Bertolotti, Christian Orange
  • Patent number: 6803018
    Abstract: A transport device conveys sample holders with medical specimens to and from treatment stations as well as sampling and dispensing stations within an autosampler. The transport device consists of a carriage which is conveyable horizontally along at least one axis with a vertically conveyable hoisting device and, arranged on the hoisting device, a coupling element for the sample holder. A collecting device to catch any liquid dripping from the sample holder can be placed underneath the sample holder during transport.
    Type: Grant
    Filed: July 14, 1998
    Date of Patent: October 12, 2004
    Assignee: Helmut Goldbecker
    Inventor: Bernd Stiller
  • Patent number: 6803019
    Abstract: A continuous form microstructure array device (20) is constructed as a flexible elongate film laminate containing microstructure arrays (26) arranged serially along the laminate. The laminate can be continuously drawn from a roll, passed through a processing and analysis device and rerolled or stacked for storage.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: October 12, 2004
    Assignee: Aclara Biosciences, Inc.
    Inventors: Torleif Ove Bjornson, Laurence R. Shea
  • Patent number: 6803020
    Abstract: The invention concerns a novel method for preparing latex by emulsion (co)polymerization of ethylenically unsaturated monomers, wherein the direct inline monitoring is carried out by Raman spectroscopy. The invention also concerns latex compositions obtainable by the emulsion (co) ploymerization method whereof the direct inline monitoring is performed by Raman spectroscopy. The invention further concerns a device for implementing said method, said device comprising a reactor, at least an optical probe, a Raman spectrometer, optical fibers, a computer and a regulating automaton.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: October 12, 2004
    Assignee: Raisio Chemicals OY
    Inventors: Mathias Agnely, Bruno Amram, Phil D. Armitage, Dominique Charmot, Bruno Drochon, Eve Pere
  • Patent number: 6803021
    Abstract: The invention relates to a device for receiving and discharging a given amount of liquid, comprising agitating means (2) arranged on one end (E1) of a capillary (1) and a diaphragm (3) in the vicinity of the other end (E2).
    Type: Grant
    Filed: October 3, 2000
    Date of Patent: October 12, 2004
    Assignee: November AG Novus Medicatus Bertling Gesellschaft fur Molekulare Medizin
    Inventor: Wolf Bertling
  • Patent number: 6803022
    Abstract: A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising a deformable bellows, a ballast mounted to the lower end of the bellows, and a float is engageable with an upper end of the bellows. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the ballast to move toward the bottom of the tube and causes an elongation and narrowing of the bellows. The separator then moves down the tube and stabilizes in a position between the separated phases of the fluid sample. Termination of the centrifugal load enables the bellows to return to its original condition in sealing engagement with the walls of the tube.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: October 12, 2004
    Assignee: Becton, Dickinson and Company
    Inventors: Paul C. DiCesare, Jeffrey R. Radziunas, Robert Losada, Fu-Chung Lin
  • Patent number: 6803023
    Abstract: A composite structure having a photocatalytic function and can be used for deodorization and wastewater treatment, comprising a foamed or porous substrate having apparent specific gravity of 0.9 to 0.01 and finely divided titanium oxide particles having a photocatalytic function which are adhered onto the surface of the foamed or porous substrate. Gas such as air having offensive odor or wastewater is allowed to be in contact with the composite structure having a photocatalytic function, whereby smelly or harmful substances contained in the gas or wastewater are decomposed.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: October 12, 2004
    Assignee: Showa Denko Kabushiki Kaisha
    Inventors: Masahiro Ohmori, Akihiko Kotera, Hidenori Nakamura, Masayoshi Nobiki
  • Patent number: 6803024
    Abstract: This invention relates to a method of treating titania slag to increase the leachability of impurities from the slag consisting of the steps of sizing the titania slag to a particle size from 75 to 850 &mgr;m; oxidizing the sized slag particles at a temperature from about 700° C. to below about 900° C. causing the iron present in the slag to concentrate at the exposed surfaces of the slag particles and/or causing an anatase phase to stabilize in the slag, causing a major portion of the iron in the Fe(II) state to convert to the Fe(III) state, and causing the titanium in the Ti(III) state to be converted to the Ti(IV) state; and reducing the oxidized slag in a reducing atmosphere from about 700° C. to about 950° C. to convert a major portion of the iron in the Fe(III) state to the Fe(II) state. The invention also relates to a method of beneficiating titania slag to increase the TiO2 content thereof wherein the above treated slag is leached with acid.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: October 12, 2004
    Assignee: Ipcor NV
    Inventors: Jacobus Philippus Van Dyk, Nanne Mattheus Vegter, Cornelia Petronella Visser, Thomas De Lange, John David Winter, Ernest Alan Walpole, Johannes Nell
  • Patent number: 6803025
    Abstract: A process of using sodium carbonate and sodium bicarbonate solutions to remove SO3 and other acidic gases or vapors from a flue gas without substantially decreasing the amount of sulfur dioxide also present in the flue gas. Very limited quantities of such solutions are injected into the flue gas in a manner that achieves a controlled droplet size, such that the solution dries on contact with the flue gas and the resulting dry particles of sodium carbonate/bicarbonate are sufficiently small as to have adequate surface area for reacting with SO3, as well as any H2SO4 and, to some extent, HCl vapors in the flue gas.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: October 12, 2004
    Inventors: Frank B. Meserole, Robert E. Moser, James H. Wilhelm
  • Patent number: 6803026
    Abstract: This invention relates to carbon black pellets obtained by compaction of carbon black powder in the presence of auxiliary substances, which pellets, despite the compaction, surprisingly exhibit greater color intensity than the powders on which they are based.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: October 12, 2004
    Assignee: Bayer Chemicals AG
    Inventors: Günter Linde, Uwe Hempelmann, Manfred Eitel
  • Patent number: 6803027
    Abstract: A process is disclosed for forming a nanosize ceramic powder. A precursor ceramic material is formed of a fugitive constituent and a non-soluble constituent in a single phase. The precursor is contacted with a selective solvent (water, acid, etc.) to form a solution of the fugitive constituent in the solvent and a residue of the non-soluble constituent. The precursor is sufficiently reactive with the solvent to form the solution of the fugitive constituent in the solvent and form the nondissolved residue of the non-soluble constituent. The precursor material and the non-soluble residue are sufficiently insoluble in the solvent such that there is insufficient precursor material and non-soluble residue in solution to deposit and precipitate upon the residue of the non-soluble-constituent.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: October 12, 2004
    Assignee: University of Utah Research Foundation
    Inventors: Anil Vasudeo Virkar, Sanjeevani Vidyadhar Bhide
  • Patent number: 6803028
    Abstract: Methods of manufacturing stoichiometric lithium niobate elements are provided. The method involves heating lithium niobate substrates in the presence of a monolithic sintered source of lithium and/or niobium. The method is useful for producing lithium niobate optical elements such as waveguides, switches and modulators.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: October 12, 2004
    Assignee: Corning Incorporated
    Inventors: Kishor P. Gadkaree, Kamal K. Soni
  • Patent number: 6803029
    Abstract: The present invention provides a process for suppressing the formation of metal-containing coke during processing of a hydrocarbonaceous material, such as for example a hydrocarbon conversion processes. The process involves using a feed comprising CO2 and steam in combination with equipment comprising high nickel and/or cobalt alloy metallurgy including aluminum or an aluminum coating in order to reduce metal catalyzed coking at process temperatures above about 800 degrees F. The process is particularly useful in the reforming of a hydrocarbon material to make hydrogen for operation in a fuel cell.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: October 12, 2004
    Assignee: Chevron U.S.A. Inc.
    Inventor: Gunther H. Dieckmann
  • Patent number: 6803030
    Abstract: Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.).
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: October 12, 2004
    Assignee: Bracco Imaging S.p.A.
    Inventors: Christoph De Haen, Andrea Beltrami, Enrico Cappelletti, Luciano Lattuada, Mario Virtuani
  • Patent number: 6803031
    Abstract: The present invention relates to the delivery of erectile dysfunction drugs through an inhalation route. Specifically, it relates to aerosols containing erectile dysfunction drugs that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an erectile dysfunction drug. In a method aspect of the present invention, an erectile dysfunction drug is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an erectile dysfunction drug, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: October 12, 2004
    Assignee: Alexza Molecular Delivery Corporation
    Inventors: Joshua D. Rabinowitz, Alejandro C. Zaffaroni
  • Patent number: 6803032
    Abstract: A shaving composition containing a skin-tightening effective amount of an astringent additive, wherein the shaving composition is applied onto human skin prior to shaving.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: October 12, 2004
    Assignee: Cognis Corporation
    Inventors: James A. McCaulley, Pat Hoontrakul
  • Patent number: 6803033
    Abstract: A process is provided for absorbing moisture and/or malodor and providing a fragrance to the surrounding ambience that includes providing a delivery vehicle containing an enrobement material, a fragrance, and a fixative, combining the delivery vehicle with an absorbent material, and contacting the mixture of delivery vehicle and absorbent material with moisture and/or a malodor source.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: October 12, 2004
    Assignee: Givaudan SA
    Inventors: Thomas McGee, Kenneth Leo Purzycki, Richard P. Sgaramella
  • Patent number: 6803034
    Abstract: The present invention relates to a composition and methods for odor and fungal control in ballistic fabrics and other protective garments. The composition is essentially free of any material that would soil or stain fabric or react negatively with the ballistic fabric or other protective gear. The composition is preferably applied as small particle size droplets, especially from spray containers. The cyclodextrin/surfactant combination, either alone, or in combination with the other ingredients, provides improved antimicrobial and antifungal activity.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: October 12, 2004
    Assignee: Procter & Gamble Company
    Inventors: Dean Larry DuVal, Kofi Ofosu-Asante, Michael Joseph Orr
  • Patent number: 6803035
    Abstract: A food product and method for treating and preventing diarrhea in a subject animal suffering from or susceptible to diarrhea. The method comprises administering an egg product to the subject animal wherein the egg product is obtained from a hyperimmunized avian.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: October 12, 2004
    Assignee: Arkion Life Sciences
    Inventors: Hellen Chaya Greenblatt, Orn Adalsteinsson, David A. Brodie, Henry Jacoby
  • Patent number: 6803036
    Abstract: The field of the invention is generally related to pharmaceutical agents useful in treating graft-versus-host disease (GVHD) in patients that have received allogenic bone marrow transplants.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: October 12, 2004
    Assignee: University of Southern California
    Inventor: David A. Horwitz
  • Patent number: 6803037
    Abstract: The present invention relates to a biological material having a matrix which contains at least one derivative of hyaluronic acid on which endothelial cells, glandular cells such as islets of Langerhans and liver cells, skin adnexa, germinative cells of hair bulbs, and kerinatocytes are grown, optionally in presence of a medium treated with fibroblasts or in a co-culture with fibroblasts. A process for the production of said biologic materials and the use of such materials for human and veterinary applications such as cardiovascular and oncological surgery, in connection with transplants, for enhancing the biological process of tissue vascularization and for aesthetic use, and also for the screening of medicaments or toxic substances and as a support in the process of gene transfection. The biological material is based on an efficacious cell culture and a biocompatible and biodegradable three-dimensional matrix containing a hyaluronic acid derivative.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: October 12, 2004
    Assignee: Fidia Advanced Biopolymers S.r.l.
    Inventors: Giovanni Abatangelo, Lanfranco Callegaro
  • Patent number: 6803038
    Abstract: The present invention relates to the use of bromelaine proteases for inhibiting blood coagulation, especially for stimulating the production of plasmin, for inhibiting the production of fibrin and for inhibiting the adhesion of human thrombocytes on endothelilum cells. Especially the basic proteases isolable from raw bromelaine have proved to be particularly suitable proteases.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: October 12, 2004
    Assignee: Ursapharm Arzneimittel GmbH
    Inventors: Rainer Maurer, Klaus Eckert, Edyta Grabowska, Klaus Eschmann
  • Patent number: 6803039
    Abstract: Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that the human monoclonal antibody is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: October 12, 2004
    Assignee: Japan Tobacco Inc.
    Inventors: Takashi Tsuji, Katsunari Tezuka, Nobuaki Hori
  • Patent number: 6803040
    Abstract: The present invention is directed to novel tricyclic antidepressant derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to tricyclic antidepressant and tricyclic antidepressant metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: October 12, 2004
    Assignee: Biosite, Inc.
    Inventors: Kenneth Francis Buechler, Joseph Barry Noar
  • Patent number: 6803041
    Abstract: A vaccine for protecting a horse against diseases associated with EHV-1 and/or EHV-4 is provided. The vaccine commonly includes inactivated EHV-1 (e.g., chemically inactivated EHV-1 KyA virus) and an adjuvant. The adjuvant can include a cross-linked olefinically unsaturated carboxylic acid polymer which may have bioadhesive properties. The vaccine may also include antigens against other equine pathogens such as inactivated EHV-4 and inactivated A1 and/or A2 strains of equine influenza virus. Methods for protecting horses against diseases associated with EHV-1 and/or EHV-4 and methods of producing the equine herpesvirus vaccine are also provided.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: October 12, 2004
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventor: Mark W. Mellencamp
  • Patent number: 6803042
    Abstract: An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccharide and formulated in accordance with the current invention for mucosal delivery such as via the oral or intranasal route is used as a vaccine. Specifically, a vaccine using shigella lipopolysaccharides complexed to proteosomes for such mucosal administration induces IgG and IgA antibodies in sera and in respiratory and intestinal fluids. Furthermore, such antibodies are associated with protection against shigella infection and these vaccines are herein demonstrated to protect against mucosal infection with shigella.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: October 12, 2004
    Assignee: U.S. Army Medical Research Materiel Command
    Inventor: George H. Lowell
  • Patent number: 6803043
    Abstract: The invention provides BASB027 polypeptides and polynucleotides encoding BASB027 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: October 12, 2004
    Assignee: GlaxoSmithKline Biologicals S.A.
    Inventor: Carlota Vinals y de Bassols
  • Patent number: 6803044
    Abstract: The present invention is directed to a method and pharmaceuticals for treating HIV and secondary infection. One aspect of this invention involves the use of one or more polypeptides with an amino acid sequence including KPV, MEHFRWG, HFRWGKPV, or SYSMEHFRWGKPV for treatment of HIV. HIV is accompanied by infections, inflammation or both. In one preferred embodiment of the invention, the one or more polypeptides are used for treatment of HIV itself via medication taken orally or parentally. In another preferred embodiment of the invention, the treatment is for secondary infections arising from Staphylococcus aureus and Candidia albicans and can be taken either orally or parentally. In another preferred embodiment of the invention, treatment is carried out by local application of the polypeptides through a carrier onto the site of S. aureus or C. albicans infection.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: October 12, 2004
    Assignee: Zengen, Inc.
    Inventors: Anna P. Catania, James M. Lipton
  • Patent number: 6803045
    Abstract: A method and apparatus for treating diaper rash including applying an anti-diaper rash cream from an applicator. The applicator includes an elongated housing containing the anti-diaper rash agent, an elliptically domed applicator portion at one end of the housing and elongated slots formed through the elliptically domed applicator portion. The anti-diaper rash agent includes zinc oxide and one or more-selected from the group consisting of aloe, vitamin E, antibacterial agent, silicon oil, petroleum.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: October 12, 2004
    Inventor: David Goldberg
  • Patent number: 6803046
    Abstract: The invention features sincalide formulations that include an effective amount of sincalide, a bulking agent/tonicity adjuster, a stabilizer, a surfactant, a chelator, and a buffer. The invention also features kits and methods for preparing improved sincalide formulations, as well as methods for treating, preventing, and diagnosing gall bladder-related disorders using sincalide formulations.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: October 12, 2004
    Assignee: Bracco International B.V.
    Inventors: Edmund C. Metcalfe, Jo Anna Monteferrante, Margaret Newborn, Irene Ropiak, Ernst Schramm, Gregory W. White, Julius P. Zodda
  • Patent number: 6803047
    Abstract: A topical composition containing an aqueous gel which contains a hydrophilic gelling material, wherein the gel has at least one of the following properties: an initial viscosity V0 ranging from 3000 to 50,000 Pa.s, wherein the initial viscosity is stable up to a shear strain C1, a viscosity V2 after shear at a strain C2, wherein a ratio of V0/V2 is greater than or equal to 1000, and a difference of C2-C1 is less than or equal to 100 Pa.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: October 12, 2004
    Assignee: L'Oreal
    Inventor: Christine Dupuis
  • Patent number: 6803048
    Abstract: Emulsifier-free cosmetic or dermatological preparations, which are finely dispersed systems of the water-in-oil type, comprising 1. an oil phase, 2. an aqueous phase and 3. one or more types of micronized, inorganic pigments which a) have an average particle size of less than 200 nm, and whose particles b) have both hydrophilic and lipophilic properties, i.e. have an amphiphilic character, and thus position themselves at the water/oil interface, and which c) are selected from the group consisting of metal oxides, which d) are optionally coated on the surface and also optionally comprising further cosmetic or pharmaceutical auxiliaries, additives and/or active substances.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: October 12, 2004
    Assignee: Beiersdorf AG
    Inventors: Heinrich Gers-Barlag, Anja Müller
  • Patent number: 6803049
    Abstract: Pickering emulsions, which are finely disperse systems of the water-in-oil or oil-in-water type, comprising (1) an oil phase, (2) a water phase, (3) at least one type of microfine particles which a) have an average particle size of less than 200 nm, which b) display both hydrophilic and lipophilic properties, i.e. which have amphiphilic character, and are dispersible both in water and in oil and which c) have optionally been coated on the surface, (4) at least one polymeric moisturizer and (5) at most 0.5% by weight of one or more emulsifiers.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: October 12, 2004
    Assignee: Beiersdorf AG
    Inventors: Heinrich Gers-Barlag, Anja Müller
  • Patent number: 6803050
    Abstract: The invention relates to optically transparent aqueous compositions containing hydrophobic silicone oil and a comparably low amount of wash-active matter, being suitable as a hair treatment composition such as a shampoo. In particular, it provides an optically transparent aqueous composition comprising (a) a hydrophobic silicone oil in an amount of 1-3 wt.-% with respect to the total weight of the composition; (b) a solubilizer for the silicone oil; and (d) an anionic surfactant; wherein the weight-ratio of component (b) to component (a) is in the range of 1:1 to 12:1; and wherein the total amount of the components (b) and (c) is in the range of 10-25 wt.-% with respect to the total weight of the composition. The invention also provides a method for preparing the above composition.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: October 12, 2004
    Assignee: Kao Chemicals Europe S.L.
    Inventors: Horst Denzer, Hiroshi Abe, Monika Pytlik, Rosemarie Jansen, Andrea Buhmann
  • Patent number: 6803051
    Abstract: A method and device are disclosed which prevent the intrusion of insects onto wood structures by using a barrier capable of retaining pesticide. In the disclosed method, the barrier maintains a minimal effective level of insecticide for a predetermined period of time.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: October 12, 2004
    Assignee: Battelle Memorial Institute K1-53
    Inventors: Peter Van Voris, Dominic A. Cataldo, Frederick G. Burton
  • Patent number: 6803052
    Abstract: The invention relates to the use of biodegradable microspheres that release a radiosensitizing anticancer agent for producing a medicament to be used simultaneously with, separately from or spread over time with a radiotherapy, for treating glioblastoma. The use of said biodegradable microspheres according to the invention results in a patient survival time of least 90 weeks, a thereapeutically effective concentration being maintained in the parenchymatous area throughout this time. The microspheres used prefereably contain 5-fluorouracile of the tumor, by intratissular injection. The radiothereapy targeting the tumorous mass is dosed at 60 Gy over approximately 6 weeks. The invention also relates to a method for producing the biodegradable microspheres by emulsion-extraction, and to a suspension containing the biodegradable microspheres obtained using this method.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: October 12, 2004
    Assignee: Laboratoires des Produits Ethiques Ethypharm
    Inventors: Nathalie Faisant, Jean-Pierre Benoit, Philippe Menei
  • Patent number: 6803053
    Abstract: The invention provides lipidic microparticles stably associated with at least two different targeting moieties, which targeting moieties are attached to linker molecules comprising a hydrophilic domain and a hydrophobic domain. The targeting moieties can be antibodies, antibody fragments, hormones, growth factors, enzymes, or nucleic acid binding proteins, or other proteins. The targeting moieties can be chemically conjugated to the linker molecules, or they can be fused by recombinant techniques.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: October 12, 2004
    Assignee: The Regents of the University of California
    Inventors: Demetrios Papahadjopoulos, Keelung Hong, Weiwen Zheng, Dmitri B. Kirpotin