Patents Issued in January 9, 2007
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Patent number: 7160953Abstract: A biocompatibilizing process in which a substrate having a surface which bears substrate pendant functional groups is biocompatibilized by coating it with a coating composition containing a polymer formed from a radical polymerizable monomers including a radical polymerisable zwitterionic monomer and a radical polymerizable monomer containing a reactive group to form a polymer having zwitterionic groups and pendant reactive groups and the said pendant reactive groups are reacted to form covalent bonds with said substrate pendant functional group and thereby form a stable coating of polymer on the said surface.Type: GrantFiled: March 10, 2004Date of Patent: January 9, 2007Assignee: Biocompatibles UK LimitedInventors: Roderick William Jonathon Bowers, Stephen Alister Jones, Peter William Stratford
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Patent number: 7160954Abstract: The present invention is directed to a golf ball and to a process for forming a golf ball having at least one layer, where the layer is formed of an ionomer composition having greater than about 70 percent of the acid groups neutralized by a neutralizing component including ammonium salts, monoamine salts, or a combination thereof.Type: GrantFiled: June 25, 2004Date of Patent: January 9, 2007Assignee: Acushnet CompanyInventors: Nathan Zieske, Murali Rajagopalan, David A. Bulpett
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Patent number: 7160955Abstract: Polymers grafted with a compound of formula I, formula (I) wherein the general symbols are as defined in claim 1, have outstanding stability against oxidative, thermal, dynamic, light-induced and/or ozone-induced degradation [R1—SOmnR—SOp—R2.Type: GrantFiled: March 26, 2002Date of Patent: January 9, 2007Assignee: Ciba Specialty Chemicals CorporationInventors: Hans-Rudolf Meier, Gerrit Knobloch, Pierre Rota-Graziosi, Samuel Evans, Paul Dubs, Michèle Gerster
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Patent number: 7160956Abstract: The present invention relates to sulfur-vulcanizable silica-containing rubber compounds with improved processability and a process for their production.Type: GrantFiled: April 11, 2003Date of Patent: January 9, 2007Assignee: Rhein Chehie Rheinau GmbHInventors: Ludger Heiliger, Thomas Früh, Michaela Meiers
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Patent number: 7160957Abstract: A method for residual monomer diminution by which a residual monomer is speedily removed from an N-vinyl compound polymer or the like without posing a problem such as an increase in ash content; and a process for producing an N-vinyl compound polymer solution or powder which has a regulated pH and is free from a decrease in pH with time. The method comprises adding an organic acid having a boiling point of 140° C. or higher at ordinary pressure to anaqueous solution of an N-vinyl compound polymer. The process comprises adding an organic base to an aqueous N-vinyl compound polymer solution having a pH lower than 7.0 to thereby neutralize the solution and regulate the pH thereof. Those operations are conducted in a reaction vessel in which a gaseous phase is regulated so as to have an oxygen concentration of 5.0% by volume or lower.Type: GrantFiled: July 8, 2003Date of Patent: January 9, 2007Assignee: Dai-Ichi Kogyo Seiyaku Co., Ltd.Inventors: Toshiaki Kuriyama, Yasuko Inui
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Patent number: 7160958Abstract: The present invention provides a method of increasing the absorption rate of peroxides into polymer particles used to fabricate electrical cable insulation. The method includes contacting the polymer particles with a peroxide compound and an additive under physical mixing conditions at a temperature that is above the melting point of the peroxide compound but below the softening point of the polymer particles for a period of time sufficient to allow he peroxide compound to absorb into the polymer particles. Preferably, the additive is squalane or another branched, hydrocarbon oil that substantially increases the rate at which the peroxide compound is absorbed into the polymer particles and improves the peroxide cure.Type: GrantFiled: May 9, 2005Date of Patent: January 9, 2007Assignee: GEO Specialty Chemicals, Inc.Inventor: Peter R. Dluzneski
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Patent number: 7160959Abstract: Comb polymers prepared by reacting an acrylic polyol or a siloxane polyol with a lactone are disclosed. These comb polymers find particular application as additives for powder coating compositions, to improve various performance properties thereof. Powder coating composition comprising the described comb polymers are also disclosed.Type: GrantFiled: March 19, 2004Date of Patent: January 9, 2007Assignee: PPG Industries Ohio, Inc.Inventors: Michael J. Ziegler, William H. Retsch, Jr., Anthony M. Chasser, Ronald R. Ambrose, Jackie L. Kulfan
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Patent number: 7160960Abstract: An acryl-based solvent-type pressure sensitive adhesive composition comprising a base component containing a solvent soluble acryl-based polymer, a cross-linking agent, and acetyl acetone, is disclosed.Type: GrantFiled: February 18, 2005Date of Patent: January 9, 2007Assignee: Toyo Ink Manufacturing Co., Ltd.Inventors: Hiroyuki Ilda, Eiichi Takama
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Patent number: 7160961Abstract: The invention relates to cast resins containing A) at least one solid unsaturated polyester and B) at least one oligomer and/or polymer cross-linking agent that can be copolymerised therewith, said cross-linking agent having at least one terminal and/or lateral propenyl-, isoprenyl- and/or (meth)acrylester group in relation to the oligomer- and/or polymer main chain. The invention also relates to the use of cast resins as casting beans and impregnants and as coating agents. The invention further relates to a method for melt impregnating or melt coating components, absorbent mattes or grounded or ungrounded substrates with the cast resins.Type: GrantFiled: July 31, 2000Date of Patent: January 9, 2007Assignee: Altana Electrical Insulation GmbHInventors: Rainer Blum, Manfred Eichhorst, Gunther Hegemann, Klaus-Wilhelm Lienert
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Patent number: 7160962Abstract: Elastomer-modified Epoxy-polysiloxane compositions of this invention are prepared by combining a silicone intermediate, with an epoxy resin, an elastomeric resinous intermediate, a polyfunctional amine, an optional organometallic catalyst, and optional fillers, pigments, and processing agents. The composition is prepared using a sufficient amount of water to promote hydrolysis of the polysiloxane and the polycondensation of the silanols produced by such hydrolysis. In its cured form, the epoxy-polysiloxane composition exists as a uniformly dispersed arrangement of linear epoxy chain fragments that are cross-linked with a continuous polysiloxane polymer chain, wherein either or both of the epoxy and/or polysiloxane polymers are elastomer modified to provide coatings and floorings having significantly improved properties of impact resistance, flexibility, crack resistance, and abrasion resistance with compared to conventional epoxy systems.Type: GrantFiled: October 27, 2003Date of Patent: January 9, 2007Assignee: Ameron International CorporationInventor: Haruji Sakugawa
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Patent number: 7160963Abstract: A toner fuser member contains a substrate on which is disposed a toner release surface layer formed from a composition that includes a silsesquioxane and a curable epoxy resin. On curing, the composition forms an interpenetrating polymer network of the silsesquioxane and cured epoxy resin.Type: GrantFiled: April 30, 2004Date of Patent: January 9, 2007Assignee: Eastman Kodak CompanyInventors: Jiann-Hsing Chen, Joseph A. Pavlisko, Muhammed Aslam, Nataly Boulatnikov
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Patent number: 7160964Abstract: A liquid-phase process for polymerizing ?-olefins of the formula CH2?CHR, where R is H or an alkyl radical C1–C6, to produce a polymer that is soluble in the reaction medium, comprising the steps of: a) continuously polymerizing in liquid phase the ?-olefin in the presence of a catalyst system based on a transition metal compound; b) continuously withdrawing from step a) a solution of polymer in the liquid reaction medium; c) mixing in one or more mixing stages said solution of polymer in the reaction medium with an organic deactivator having: at least a hydroxy group, a boiling point higher than 150° C., and a ratio between the molecular weight (MW) and the number of hydroxy groups (OH) comprised between 20 and 100.Type: GrantFiled: June 17, 2003Date of Patent: January 9, 2007Assignee: Basell Poliolefine Italia S.p.A.Inventors: Daniele Bigiavi, Gabriele Mei, Nicolo' Arich De Finetti, Giuseppe Penzo, Gianni Vitale, Massimo Covezzi
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Patent number: 7160965Abstract: A catalyst system useful to polymerize and co-polymerize polar and non-polar olefin monomers is formed by in situ reduction with a reducing agent of a catalyst precursor comprising {Cp*MRR?n}+{A}? wherein Cp* is a cyclopentadienyl or substituted cyclopentadienyl moiety; M is an early transition metal; R is a C1–C20 hydrocarbyl; R? are independently selected from hydride, C1–C20 hydrocarbyl, SiR?3, NR?2, OR?, SR?, GeR?3, SnR?3, and C?C-containing groups (R?=C1–C10 hydrocarbyl); n is an integer selected to balance the oxidation state of M; and A is a suitable non-coordinating anionic cocatalyst or precursor. This catalyst system may form stereoregular olefin polymers including syndiotactic polymers of styrene and methylmethacrylate and isotactic copolymers of polar and nonpolar olefin monomers such as methylmethacrylate and styrene.Type: GrantFiled: May 4, 2005Date of Patent: January 9, 2007Assignee: Northwestern UniversityInventors: Tobin J. Marks, Lubin Luo, Sung Cheol Yoon
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Patent number: 7160966Abstract: The present invention relates to selected 1-alkoxy-2,2 diethyl-6,6 dimethyl piperidine and 1-alkoxy-2,6 diethyl-2,3,6 trimethyl piperidine derivatives which are substituted in the 4 position by an oxygen or nitrogen atom; a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) said piperidine derivatives. Further aspects of the present invention are a process for polymerizing ethylenically unsaturated monomers, and the use of 1-alkoxy-2,2 diethyl-6,6 dimethyl piperidine and 1-alkoxy-2,6 diethyl-2,6 dimethyl piperidine derivatives which are substituted in the 4 position by an oxygen or nitrogen atom for controlled polymerization. The intermediate N-oxyl derivatives, a composition of the N-oxyl derivatives with ethylenically unsaturated monomers and a free radical initiator, as well as a process for polymerization are also subjects of the present invention.Type: GrantFiled: February 1, 2005Date of Patent: January 9, 2007Assignee: Ciba Specialty Chemicals Corp.Inventors: Peter Nesvadba, Marie-Odile Zink, Andreas Kramer
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Patent number: 7160967Abstract: Fluorovinyl ethers having the formula CFX?CXOCF2OR, wherein R is a C2–C6 linear, branched or C5–C6 cyclic (per)fluoroalkyl group, or a C2–C6 linear, branched (per)fluoro oxyalkyl group containing from one to three oxygen atoms; when R is fluoroalkyl or fluorooxyalkyl group as above defined, it can contain from 1 to 2 atoms, equal or different, selected from the following: H, Cl, Br, I; X?F, H; and homopolymers or polymers obtainable polymerizing said Fluorovinyl ethers with at least another polymerizable monomer.Type: GrantFiled: April 27, 2005Date of Patent: January 9, 2007Assignee: Solvey Solexis S.p.A.Inventor: Walter Navarrini
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Patent number: 7160968Abstract: The invention relates to solid polyelectrolyte membranes and processes for their production. As solid polyelectrolyte materials, there have been known fluoropolymers which have perfluoroskeletons and side chains bearing sulfonic acid groups and heat-resistant resins which have hydrocarbon skeletons and contain alkylsulfonic acid or alkylphosphoric acid groups introduced thereto. The fluoropolymers are excellent in heat resistance and chemical resistance but have the problem of being expensive, while the heat-resistant resins have the problem of being poor in chemical resistance. Further, solid polyelectrolyte materials having higher electric conductivities have been desired.Type: GrantFiled: October 19, 2001Date of Patent: January 9, 2007Assignee: Canon Kabushiki KaishaInventors: Iko Ito, Masahiro Rikukawa
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Patent number: 7160969Abstract: The invention relates to metathesis oligomers wherein one or more alkoxy ether groups are attached to the oligomer moiety. Also disclosed is a polymerizable composition comprising a catalytically effective amount of a penta- or hexavalent ruthenium or osmium carbene catalyst, the process for preparing the metathesis polymer by applying the reaction conditions of Ring Opening Metathesis Polymerization (=ROMP) to the polymerisable composition; and various technical applications of the metathesis oligomers as antifog agents.Type: GrantFiled: March 8, 2002Date of Patent: January 9, 2007Assignee: Ciba Specialty Chemicals Corp.Inventors: Piero Piccinelli, Manuel Vitali, Alessandro Zedda
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Patent number: 7160970Abstract: The present invention is directed to methods for preparing multi-functional emulsion polymers.Type: GrantFiled: September 17, 2004Date of Patent: January 9, 2007Assignee: Rohm and Haas CompanyInventors: Marianne Patricia Creamer, Lester William Greene, Jr., Ari Kenneth Kar, Miao Wang
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Patent number: 7160971Abstract: The present invention provides novel multi-functional methacrylic copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility under acidic conditions. The copolymers are constructed from tertiary amine methacrylates and poly(ethylene glycol) containing methacrylates. The copolymers are useful as gene vectors, pharmaceutical carriers, and in protein separation applications.Type: GrantFiled: November 22, 2005Date of Patent: January 9, 2007Assignee: Iowa State University Research FoundationInventors: Surya K. Mallapragada, Brian C. Anderson, Paul D. Bloom, Valerie V. Sheares Ashby
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Patent number: 7160972Abstract: A thermally stable polysiloxane composition is a cross-linked product of a Part A composition, of a Part B composition and a catalyst, the Part A composition being a polysiloxane having 60 to 75 percent by weight phenyl groups, the Part B composition being a polysiloxane having 50 to 80 percent by weight phenyl groups. The composition has the properties of optical clarity as measured by 90% or greater transmission of light of 400 nm wavelength in a 1.0 centimeter path, a refractive index at 589 nm of 1.545 or greater and still has 90% or greater transmission of light of 400 nm wavelength in a 1.0 centimeter path after exposure to 150° C. for 6 hours. The composition is well suited for application as an optically transmissive cover or lens for light emitting diodes and for use in other optical and related devices.Type: GrantFiled: February 12, 2004Date of Patent: January 9, 2007Assignee: NuSil Technology LLCInventors: Nickelous David Young, David B. Stone, legal representative, Robert Vincent Thomaier, Keith Bryan Reichel, David Stevenson Stone, deceased
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Patent number: 7160973Abstract: A composition comprising a reaction product of a diisocyanate, a chain extension agent having at least difunctional reactivity with an isocyanate, and a material comprising a blend of i) a primary carbamate material having at least one functional group reactive with an isocyanate and at least one primary carbamate group or a group convertible to a primary carbamate group, and ii) a reaction product of the primary carbamate material with an extending agent, wherein at least one of i) the isocyanate groups of the diisocyanate have a different reactivity in relation to each other, and ii) at least two of the groups with reactivity with an isocyanate on the chain extension agent have a different reactivity in relation to each other.Type: GrantFiled: December 12, 2002Date of Patent: January 9, 2007Assignee: BASF CorporationInventors: Walter H. Ohrbom, Craig S. Schang, Joanne Casale, Thaddeus J. Lepkowski
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Patent number: 7160974Abstract: The present invention relates to thermoplastically processable polyurethane elastomers (TPU) with tensile strengths of >35 MPa (measured in accordance with EN ISO 527-3), with shrinkages of <3% and with self-extinguishing properties based on the use of at least one flameproofing agent which can be built in, a process for their preparation and their use.Type: GrantFiled: August 18, 2003Date of Patent: January 9, 2007Assignee: Bayer MaterialScience AGInventors: Henricus Peerlings, Wolfgang Bräuer, Hans-Georg Wussow, Juergen Winkler, Hans-Georg Hoppe
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Patent number: 7160975Abstract: This invention relates to ethylenically unsaturated macromers which contain reactive unsaturation, and to a process for preparing these ethylenicallly unsaturated macromers which contain reactive unsaturation. The process of preparing these ethylenically unsaturated macromers comprises reacting a monofunctional compound which corresponds to a specific formula with at least one alkylene oxide, in the presence of at least one alkoxylation catalyst. The ethylenically unsaturated macromers correspond to the formula set forth herein. This invention also relates to preformed stabilizers comprising ethylenically unsaturated macromers, to a process for preparing these preformed stabilizers, to polymer polyols comprising these preformed stabilizers, and to a process of preparing these polymer polyols which comprise these preformed stabilizers. Polymer polyols comprising ethylenically unsaturated macromers and a process for their preparation are also described.Type: GrantFiled: August 2, 2004Date of Patent: January 9, 2007Assignee: Bayer MaterialScience LLCInventors: Rick L. Adkins, Scott A. Guelcher
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Patent number: 7160976Abstract: Pressure-sensitive adhesive based on polyurethane, characterized in that the polyurethane is composed of the following starting materials which are reacted with one another in the stated proportions: a) at least one aliphatic or alicyclic diisocyanate having in each case an asymmetrical molecular structure, b) a combination of at least one polypropylene glycol diol and at least one polypropylene glycol triol, the ratio of the number of hydroxyl groups in the diol component to the number of hydroxyl groups in the triol component being between 0.7 and 9.0, preferably between 1.5 and 2.5, additionally the ratio of the number of isocyanate groups to the total number of hydroxyl groups being between 0.9 and 1.1, preferably between 0.95 and 1.Type: GrantFiled: April 1, 2004Date of Patent: January 9, 2007Assignee: tesa AktiengesellschaftInventors: Bernd Lühmann, Philippe Hesse, Sianty Sunarto, Uwe Schümann, Kirstin Weiland, Carsten Böhmer
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Patent number: 7160977Abstract: This invention relates to a blend of biodegradable polymers comprising: (A) about 70% to about 80% by weight of at least one flexible biodegradable polymer (A) having a glass transition less than about 0° C., (B) about 30% to about 20% by weight of at least one rigid biodegradable polymer (B) having a glass transition greater than about 10° C.; said percentages being based on the total weight of the polymer blend; wherein said polymer blend has a notched Izod impact strength according to ASTM D256 of at least 7.5 ft-lbs/in.Type: GrantFiled: December 6, 2004Date of Patent: January 9, 2007Assignee: Eastman Chemical CompanyInventors: Wesley Raymond Hale, Candace Michele Tanner
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Patent number: 7160978Abstract: A method of making amide polymers with improved back-bone rigidity, stability and/or planarity through the promotion of intra-molecular interactions is disclosed. Amide polymers, in accordance with the embodiments of the invention, are formed using aromatic dicarboxylic acids and heterocyclic diamine precursors or reactive amino-acid heterocyclic precursors. The heterocyclic precursors used in the present invention have heterocyclic structures that include hetero-atoms in a position that is beta relative to one or more reactive amine groups. Preferably, the hetero-atoms are nitrogen atoms. In accordance with further embodiments, precursors include functional groups that promote inter-molecular interactions, intra-molecular interactions and/or enhance solubility of the amide polymers formed.Type: GrantFiled: February 27, 2004Date of Patent: January 9, 2007Inventor: Steven W. Fowkes
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Patent number: 7160979Abstract: The reaction of dimer acids, C6 to C18 aliphatic dicarboxylic acids, dimer amines, alkylene diamines having from 2 to 8 carbon atoms, and polyoxyalkylene diamines provides polyamides having excellent cold flexibility, high heat resistance, and low moisture absorbency (low water vapor transmission).Type: GrantFiled: October 25, 2004Date of Patent: January 9, 2007Assignee: Henkel CorporationInventors: Tina Nataniel, Dwight Heinrich
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Patent number: 7160980Abstract: Method of purifying a polymeric material of a type which includes (A) phenyl moieties; (B) carbonyl and/or sulphone moieties; and; (C) ether and/or thioether moieties. The method includes contacting the polymeric material with a solvent formulation which is at a temperature of greater than 100° C. and a pressure above ambient pressure thereby to charge the solvent formulation with impurities derived from the polymeric material, and separating the charged solvent from the polymeric material.Type: GrantFiled: May 29, 2002Date of Patent: January 9, 2007Assignee: Victrex Manufacturing LimitedInventors: John Neil Devine, Stuart Green, David John Kemmish, Brian Wilson
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Patent number: 7160981Abstract: The invention provides a polypeptide consisting essentially of a sequence corresponding to residues 163 to 199 of DP-1 as shown in the Figure, and fragments and variants thereof capable of antagonizing the heterodimerization of a DP protein with an E2F protein. Such peptides may be used to induce apoptosis in a cell by introducing into the cell an effective amount of said peptide. Such cells include cardiovascular cells, and the peptide may be delivered in a stent to treat or prevent restinosis.Type: GrantFiled: July 9, 2001Date of Patent: January 9, 2007Assignee: Prolifix LimitedInventors: Nicholas B. La Thangue, Lasantha R. Bandara
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Patent number: 7160982Abstract: A peptide substrate is identified by type BoNT/B botulinus toxin, characterized in that it incorporates in its structure a fragment of formula PYA-(Z)-pNF, wherein Z represents one or several amino acids, said fragment being cleavable by said toxin.Type: GrantFiled: May 31, 2001Date of Patent: January 9, 2007Assignee: Institut National de la Sante et de la Recherche Medicale (Inserm)Inventors: Bernard Roques, Christine Anne
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Patent number: 7160983Abstract: Compound of the formula wherein R2 is —CH2—CH2—NH2, R3 is —CH3, R4 is —OH, R is Z is methyl and salts thereof which are useful as antifungal agents.Type: GrantFiled: September 19, 2003Date of Patent: January 9, 2007Assignee: Aventis Pharma S.A.Inventors: Olivier Courtin, Patrick Fauveau, Astrid Markus, Dominique Melon Manguer, Jean-Marc Michel, Laurent Schio
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Patent number: 7160984Abstract: Disclosed are processes for preparing glycopeptide antibiotic derivatives having an amino-containing side chain. The multi-step process is conducted in a single reaction vessel without isolation of intermediate reaction products.Type: GrantFiled: November 8, 2005Date of Patent: January 9, 2007Assignee: Theravance, Inc.Inventors: Junning Lee, Jyanwei Liu
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Patent number: 7160985Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: December 6, 2001Date of Patent: January 9, 2007Assignee: Genentech, Inc.Inventors: Audrey Goddard, Paul J Godowski, J Christopher Grimaldi, Austin L Gurney, William I Wood
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Patent number: 7160986Abstract: The present invention relates to BCL-x?, a novel isoform of the BCL-x family of proteins which is predominantly expressed in T-lymphocytes and is associated with resistance to apoptosis. Both compositions of matter and methods are described which are useful in the treatment or prevention of immune system disorders.Type: GrantFiled: July 29, 2002Date of Patent: January 9, 2007Assignee: Dana-Farber Cancer Institute, Inc.Inventors: Xiao-Feng Yang, Georg F. Weber, Harvey Cantor
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Patent number: 7160987Abstract: A method for the prevention or reversal of transplant rejection, or for therapy for autoimmune diseases, is provided comprising administering compounds such as monoclonal antibodies, that bind specifically to one or more preselected CD45R leukocyte antigens, including the CD45RB epitope.Type: GrantFiled: March 19, 2002Date of Patent: January 9, 2007Assignee: Alimunne, L.L.C.Inventors: Andrew I. Lazarovits, Sibrand Poppema
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Patent number: 7160988Abstract: We disclose isolated terminal fusion polypeptides comprising a soybean glycinin or proglycinin polypeptide operably linked to the peptide of SEQ ID NO:12.Type: GrantFiled: March 5, 2004Date of Patent: January 9, 2007Assignee: Pioneer Hi-Bred International, Inc.Inventors: Keith R. Roesler, Jennifer K. Barry, Aragula Gururaj Rao
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Patent number: 7160989Abstract: A phosphorylation site-specific antibody that recognizes phosphorylated serine 213 within the N-terminus of the androgen receptor was obtained which can be used in methods for determining the presence of activated androgen receptors in cells or tissue of human androgen responsive tissue and for screening for an androgen inhibitor or an androgen agonist.Type: GrantFiled: May 20, 2004Date of Patent: January 9, 2007Assignee: New York UniversityInventors: Susan K. Logan, Michael J. Garabedian
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Patent number: 7160990Abstract: A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding activity and a recombinant DNA molecule coding for the protein (or fragments thereof), and micro-organisms (including viruses) containing this recombinant DNA molecule. The present invention further comprises the therapeutic and diagnostic use of the protein and/or DNA, e.g., a diagnostic kit for determining the presence and/or type of coagulase negative staphylococci and a vaccine composition, comprising the protein or DNA.Type: GrantFiled: March 23, 2004Date of Patent: January 9, 2007Assignee: Biostapro ABInventors: Bengt Guss, Martin Nilsson, Lars Frykberg, Jan-Ingmar Flock, Martin Lindberg
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Patent number: 7160991Abstract: The present invention relates generally to an isolated molecule having vascular endothelial growth factor-like properties and to a genetic sequence encoding same. The molecule will be useful in the development of a range of therapeutics and diagnostics useful in the treatment, prophylaxis and/or diagnosis of conditions requiring enhanced or diminished vasculature and/or vascular permeability. The molecule of the present invention is also a useful effector of primary and central neurons and is capable of inducing astroglial proliferation.Type: GrantFiled: January 27, 1999Date of Patent: January 9, 2007Assignees: Ludwig Institute for Cancer Research, Licentia Ltd.Inventors: Nicholas Kim Hayward, Gunther Weber, Sean Grimmond, Magnus Nordenskjold, Catharina Larsson
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Patent number: 7160992Abstract: Novel amino-modified polysaccharides are provided. The amino-modified polysaccharides have one or more amino groups, each being linked to one or more arginine residues.Type: GrantFiled: April 26, 2004Date of Patent: January 9, 2007Assignee: Yeda Research and Development Co., Ltd.Inventors: Aviva Lapidot, Veerappan Vijayabaskar, Gadi Borkow
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Patent number: 7160993Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: May 21, 2002Date of Patent: January 9, 2007Assignee: Genentech, Inc.Inventors: Kevin P. Baker, Maureen Beresini, Laura DeForge, Luc Desnoyers, Ellen Filvaroff, Wei-Qiang Gao, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Steven Sherwood, Victoria Smith, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, William I. Wood, Zemin Zhang
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Patent number: 7160994Abstract: Isolated nucleic acid and amino acid sequence for osteoclast-specific genes and proteins are provided. Methods for using these osteoclast-specific genes and proteins in the detection and isolation of osteoclasts, in production of antibodies specific to osteoclasts and to identify agents capable of modulating osteoclast function and treating diseases linked to osteoclasts are also provided.Type: GrantFiled: February 14, 2003Date of Patent: January 9, 2007Assignee: Trustees of the University of PennsylvaniaInventor: Yongwon Choi
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Patent number: 7160995Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-? (TNF?) and are useful in vivo diagnosis and therapy of a number of TNF?-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.Type: GrantFiled: July 22, 2002Date of Patent: January 9, 2007Assignees: New York University, Centocor, Inc.Inventors: Junming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel
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Patent number: 7160996Abstract: The present invention provides a class of Conformationally Assisted Probes comprising (a) a nucleic acid moiety; (b) an energy donor moiety; (c) an energy acceptor moiety; and (d) one or more stabilizing moieties.Type: GrantFiled: June 8, 2000Date of Patent: January 9, 2007Assignee: Bioresearch Technologies, Inc.Inventor: Ronald M. Cook
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Patent number: 7160997Abstract: Methods and compositions are provided for detecting a primer extension product in a reaction mixture. In the subject methods, a primer extension reaction is conducted in the presence of a polymerase having 3??5? exonuclease activity and at least one FET labeled oligonucleotide probe that includes a 3??5? exonuclease resistant quencher domain. Also provided are systems and kits for practicing the subject methods. The subject invention finds use in a variety of different applications, and are particularly suited for use in high fidelity PCR based reactions, including SNP detection applications, allelic variation detection applications, and the like.Type: GrantFiled: August 15, 2002Date of Patent: January 9, 2007Inventors: Quin Chou, Dragan Spasic
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Patent number: 7160998Abstract: The present invention is directed to kits for monitoring a nucleic acid during amplification. More particularly, the present invention relates to kits comprising a first oligonucleotide labeled with a first fluorophore, a second oligonucleotide labeled with a second fluorophore, and components for amplifying the locus, wherein the first and second fluorophores comprise a fluorescence resonance energy transfer pair. Hybridization of at least the first oligonucleotide to the amplified locus places the first and second fluorophores in a resonance energy transfer relationship.Type: GrantFiled: March 26, 2003Date of Patent: January 9, 2007Assignee: University of Utah Research FoundationInventors: Carl T. Wittwer, Randy P. Rasmussen, Marla Lay
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Patent number: 7160999Abstract: A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers. The nucleoside enantiomer (?)-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.Type: GrantFiled: August 20, 2003Date of Patent: January 9, 2007Assignee: Emory UniversityInventors: Dennis C. Liotta, Raymond F. Schinazi, Woo-Baeg Choi
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Patent number: 7161000Abstract: Provided is a method for producing a phenol condensate by oxidative condensation of a phenol compound not having a substituted group on at least one ortho-position, in the presence of a specific complex (II) and oxygen, wherein a condensate coupled at para-position of the phenol can be produced in an excellent yield, L-M (X)n??(II) wherein L represents a ligand having 2 to 4 nitrogen atoms as donor atoms, M represents copper ion, nickel ion, cobalt ion, iron ion, manganese ion, chromium ion or vanadyl ion, X represents a counter ion, n is a number of Xs.Type: GrantFiled: May 27, 2004Date of Patent: January 9, 2007Assignee: Sumitomo Chemical Company, LimitedInventors: Hideyuki Higashimura, Eiichi Kotake, Masaaki Kubota, Shiro Kobayashi
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Patent number: 7161001Abstract: A method is provided for synthesizing acylamides, useful as protectant for cultivated plants. A benzoxazine, such as 3,4-dihydro-3-methyl-2H-1,4-benzoxazine, is made in a stepwise manner by initially forming an o-nitrophenoxyketone by reacting a haloketone and a nitrophenol. The o-nitrophenoxyketone is hydrogenated to form the corresponding benzoxazine, which is thereafter acylated with an acylhalide to produce the acylamide, such as 4-dichloroacetyl-3,4-dihydro-3-methyl-2H-1,4-benzoxazine.Type: GrantFiled: August 15, 2005Date of Patent: January 9, 2007Assignee: Syngenta Crop Protection, Inc.Inventors: Catherine Munson, legal representative, Michael Allen Oliver, Heinz Peter Schwemlein, Robert Eugene Munson, deceased
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Patent number: 7161002Abstract: The present invention provides novel quinazolinone compositions of matter comprising enantiomerically pure compound represented by Formula I: or a pharmaceutically acceptable salt thereof, having a detectable amount of one or more starting material and/or reagent used in the synthesis thereof.Type: GrantFiled: October 20, 2005Date of Patent: January 9, 2007Assignees: Cytokinetics, Inc., SmithKline Beecham CorporationInventors: Gustave Bergnes, Edward Ha, George Yiannikourous, Panos Kalaritis, Brandon E. Yonce, Kurt Alan Welday, Jr.