Patents Issued in January 9, 2007
  • Patent number: 7161003
    Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: January 9, 2007
    Assignees: Schering Corporation, Pharmacopeia Drug Discovery, Inc.
    Inventors: Timothy J. Guzi, Kamil Paruch, Michael P. Dwyer, Ronald J. Doll, Viyyoor M. Girijavallabhan, Alan Mallams, Carmen S. Alvarez, Kartik M. Keertikar, Jocelyn Rivera, Tin-Yau Chan, Vincent Madison, Thierry O. Fischmann, Lawrence W. Dillard, Vinh D. Tran, Zhen Min He, Ray Anthony James, Haengsoon Park, Vidyadhar M. Paradkar, Douglas Walsh Hobbs
  • Patent number: 7161004
    Abstract: Intermediate compounds for preparing rosuvastatin are prepared by a process comprising oxidizing hydroxy groups to aldehyde groups, using sodium hypochlorite and 2,2,6,6-tetramethyl piperidinyl oxy free radical (TEMPO) as a catalyst.
    Type: Grant
    Filed: June 21, 2005
    Date of Patent: January 9, 2007
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Srinivasulu Gudipati, Srinivas Katkam, Rajeshwar Reddy Sagyam, Jaya Satyanaraya Kudavalli
  • Patent number: 7161005
    Abstract: Use of metal complex compounds of formula [LnMemXp]zYq??(1) wherein Me is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, n and m are each independently of the other an integer having a value of from 1 to 8, p is an integer having a value of from 0 to 32, z is the charge of the metal complex, y is a counter-ion, q=z/(charge Y), and L is a ligand of formula wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are each independently of the others hydrogen; unsubstituted or substituted C1–C18alkyl or aryl; cyano; halogen; nitro; —COOR12 or —SO3R12 wherein R12 is in each case hydrogen, a cation or unsubstituted or substituted C1–C18alkyl or aryl; —SR13, —OR13 or —OR13 wherein R13 is in each case hydrogen or unsubstituted or substituted C1–C18alkyl or aryl; —N(R13)—NR?13R?13 wherein R13, R?13 and R?13 are as defined above for R13; —NR14R15 or —N?R14R15R16 wherein R14, R15 and R16 are each independently of the other(s) hydrogen or unsubstituted or substi
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: January 9, 2007
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Gunther Schlingloff, Torsten Wieprecht, Frank Bachmann, Josef Dannacher, Marie-Josée Dubs, Menno Hazenkamp, Grit Hänsler (-Richter), Brigitte Schmidt, Albert Schneider, Peter Weingartner
  • Patent number: 7161006
    Abstract: The invention provides compounds of formula I: which are inhibitors of ?-secretase and hence useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: January 9, 2007
    Assignee: Merck Sharp & Dohme Limited
    Inventors: James Michael Crawforth, Jason Matthew Elliott, Andrew Pate Owens, Francine Sternfeld
  • Patent number: 7161007
    Abstract: The present invention relates to a process of preparing quinacridone by oxidizing a 6,13-dihydroquinacridone salt corresponding to the quinacridone pigment with hydrogen peroxide as the oxidizing agent in the presence of 2,7-anthraquinone disulfonic acid as catalyst. The inventive process is economical and environmentally friendly and yields high performance quinacridone pigments in a high yield.
    Type: Grant
    Filed: July 8, 2003
    Date of Patent: January 9, 2007
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Fridolin Bäbler, Hans Rudolf Merstetter
  • Patent number: 7161008
    Abstract: The invention relates to chiral Mannich bases of formula (I), chiral 1,3-amino alcohols of formula (II) derived therefrom, wherein R1, R2, R3, R4 and R5 are as defined herein, and to processes for preparing Mannich salts of formula (III) containing a chiral anion Y*? and compounds of formulae (I) and (II), wherein R1, R2, R3, R4, R5 and Y*? are as defined herein.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: January 9, 2007
    Assignee: Sanofi - Aventis Deutschland GmbH
    Inventors: Heiner Jendralla, Wilfried Schwab, Thomas Stuedemann
  • Patent number: 7161009
    Abstract: The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: January 9, 2007
    Assignee: Elbion AG
    Inventors: Norbert Höfgen, Ute Egerland, Hildegard Poppe, Degenhard Marx, Stefan Szelényi, Thomas Kronbach, Emmanuel Polymeropoulos, Sabine Heer
  • Patent number: 7161010
    Abstract: Disclosed is a compound represented by the following formula (I): wherein Z1 represents an atomic group necessary to form a 5- or 6-membered nitrogen-containing heterocyclic ring; Z2 represents an atomic group necessary to form a 5- or 6-membered heterocyclic ring, Z2 may further be substituted, or may be condensed with a hetero ring of a benzene ring; R1 represents a hydrogen atom, a halogen atom, a mercapto group, an alkyl group, an alkenyl group, an aryl group, an alkylthio group, an alkenylthio group, or an arylthio group; L1 and L2 each represents a methine group; pi represents 0 or 1; V1 represents a substituent; and n represents 0, 1 or 2, and when n represents 2, a plurality of V1 may be the same or different.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: January 9, 2007
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Katsumi Kobayashi, Takashi Katoh, Junji Nishigaki
  • Patent number: 7161011
    Abstract: Described is a process for the preparation of a compound of the formula wherein R is unsubstituted or substituted C1–C12alkyl, C2–C4alkenyl, C2–C4alkynyl, C3–C6cycloalkyl, aryl or heteroaryl, or —SR1; R1 is unsubstituted or substituted C1–C12alkyl, C2–C4alkenyl, C2–C4alkenyl, C2–C4alkynyl, cycloalkyl, aryl or heteroaryl; and X is a leaving group; which comprises a) reacting a compound of the formula wherein R is as defined for formula (I), with a water removing reagent.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: January 9, 2007
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Thomas Pitterna, Henry Szczepanski, Peter Maienfisch, Ottmar Franz Hüter, Thomas Rapold, Marcel Senn, Thomas Göbel, Anthony Cornelius O'Sullivan
  • Patent number: 7161012
    Abstract: The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: January 9, 2007
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Limor Tessler, Judith Aronhime, Revital Lifshitz-Liron, Dalia Maidan-Hanoch, Nir Hasson
  • Patent number: 7161013
    Abstract: A novel terthiophene-3-carboxylic acid compound is disclosed that a functionalized conductive terthiophene polymer having carboxylic groups produced in an electrochemical method using the compound as a monomer and a novel process for detecting DNA hybridization through impedance measurement using the polymer. In addition, a method for manufacturing a probe DNA used in the process for detecting DNA hybridization is provided. Since the process can detect DNA hybridization using impedance change, without the use of any indicator, small-sized sensor systems which measure impedance in a particular frequency range can be fabricated. The systems are applicable to portable sensors for identifying DNA sequence hybridization for clinical examination and disease diagnosis. Further, the process has an excellent selectivity of complementary sequences to mismatched sequences.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: January 9, 2007
    Assignee: Pusan National University Industry-University Cooperation Foundation
    Inventor: Yoon-Bo Shim
  • Patent number: 7161014
    Abstract: Process for converting certain lactones to their alpha-methylene substituted forms that not only exhibits high initial activity (conversion), but also maintains a high level of activity with time on stream.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: January 9, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Kostantinos Kourtakis, Leo Ernest Manzer
  • Patent number: 7161015
    Abstract: A method of making a compound by: providing a furyl compound being 2-furoyl chloride or corresponding carboxylic acid, amide, ester, anhydride, or lactone; reacting the furyl compound with CH3O(CH3)NH.HCl to form an amide; reacting the amide with an alkane Grignard reagent or alkyllithium to form a chelated intermediate; and reacting the chelated intermediate with an aqueous acid to form a (2-furyl)-alkylketone.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: January 9, 2007
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Linda Passaro
  • Patent number: 7161016
    Abstract: Novel analogs of arachidonylethanolamide are presented which have higher affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and selectivity and/or greater metabolic stability make these analogs therapeutically useful as medications for relief of pain caused by cancer and nausea caused by chemotherapy, as well as for peripheral pain. The compounds may also be useful as oral and topical contraceptives, in suppression of the immune system, enhancement of appetite and in treatment of psychomotor disorders, multiple sclerosis and hypertension.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: January 9, 2007
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Atmaram Khanolkar, Andreas Goutopoulos
  • Patent number: 7161017
    Abstract: A process for producing unsaturated and saturated free fatty acid from trap oils, trap greases, brown greases and grease trap waste as starting material. The process consist in subjecting the starting material to a pretreatment, a first purification step, a fractional step, a second purification step and eventually a hydrogenation step. Methyl esters of unsaturated and saturated free fatty acids, oleic acid and stearin is obtained from this process.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: January 9, 2007
    Assignee: Prolab Technologies Inc.
    Inventors: Juan Miguel Garro, Alain Lemieux, Paul Jollez, Nicole Cadoret
  • Patent number: 7161018
    Abstract: A series of soluble ?-diimine late transition metal catalysts has been invented. The catalysts demonstrate high activity and selectivity for linear ?-olefins. As such, these catalysts conveniently oligomerize ethylene. Typical activators as known to those of ordinary skill in the art are used to activate these transition metal catalyst. These catalysts can be used in a supported or unsupported form.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: January 9, 2007
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Baiyi Zhao, Enock Berluche, Smita Kacker, Jo Ann Marie Canich
  • Patent number: 7161019
    Abstract: A compound of the general formula R1MR4R5R6 is provided where R1 is a partially or fully fluorinated aryl, alkyl, alkenyl or alkynyl group, wherein M is selected from group 14 of the periodic table, wherein R4, R5 and R6 are independently an alkoxy group OR3 or a halogen group X—except, a) where R4, R5 and R6 are each ethoxy, M is Si and R1 is perfluorinated phenyl or perfluorinated vinyl; b) where R4 is ethoxy, R5 and R6 are chlorine, M is Si, and R1 is perfluorinated phenyl; or c) where R4, R5 and R6 are chlorine, M is Si, and R1 is perfluorinated phenyl, perfluorinated methyl or perfluorinated vinyl. This compound formed can be further reacted to attach an additional organic R group, and/or hydrolyzed, alone or with one or more similar compounds, to form a material having a molecular weight of from 500 to 10,000, which material can be deposited on various substrates as a coating or deposited and patterned for a waveguide or other optical device components.
    Type: Grant
    Filed: June 8, 2004
    Date of Patent: January 9, 2007
    Assignee: Silecs Oy
    Inventors: Juha A. Rantala, Arto L. T. Maaninen, Tina J. Maaninen, Jarkko J. Pietikainen
  • Patent number: 7161020
    Abstract: Phosphites of the formula I and phosphite-metal complexes, their preparation and their use in catalytic reactions, in particular in processes for the hydroformylation of olefins, are described.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: January 9, 2007
    Assignee: Oxeno Olefinchemie GmbH
    Inventors: Detlef Selent, Armin Boerner, Cornelia Borgmann, Dieter Hess, Klaus-Diether Wiese
  • Patent number: 7161021
    Abstract: In a process for producing a polynitrile compound comprising introducing a polysubstituted organic compound (POC) which is a carbon ring or heterocyclic compounds having a plurality of organic substituents into a reactor with ammonia and a gas containing oxygen and ammoxidizing POC in the presence of a catalyst, at least a portion of the unreacted POC and a mononitrile compound of an intermediate product in the reaction gas discharged from the reactor is separated, recovered and recycled to the reactor so that the flow rate of the mononitrile compound at the outlet of the reactor is 2 to 16% by mole of the total flow rate of POC and the mononitrile compound supplied to the reactor. Burning reaction of the side reaction is suppressed and the loss of POC can be decreased without adverse effects on productivity and the polynitrile compound can be obtained at a high yield.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: January 9, 2007
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Kenichi Nakamura, Shuji Ebata, Fumio Tanaka, Takuji Shitara
  • Patent number: 7161022
    Abstract: A 4-phenyl-4-oxo-2-butenoate derivative is stably supplied in a short period of time, at low cost, in high purity and on an industrial scale by a process for producing the 4-phenyl-4-oxo-2-butenoate derivative, which comprises simultaneously or continuously reacting a sulfuric ester, an aromatic hydrocarbon and a maleic anhydride derivative.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: January 9, 2007
    Assignees: Fujifilm Finechemicals Co., Ltd., Meiji Seika Kaisha, Ltd.
    Inventors: Isamu Itoh, Taichi Shintou
  • Patent number: 7161023
    Abstract: A system for recovering a diacetylenic monomer shelf life monitoring compound of reduced particle size and narrow size distribution range which comprises quenching a solution of the monomer by mixing the solution in a lower temperature quenching fluid having a base temperature which is at least about 30° C. below the nominal temperature at which the monomer compound recrystallizes from solution, the mixing being effected in such a manner as to limit the resulting quenching mixture temperature to one which is not higher than a maximum of about 15° C. above the quenching fluid base temperature.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: January 9, 2007
    Assignee: Temptime Corporation
    Inventors: Thaddeus Prusik, Dawn E. Smith, Ingo H. Leubner, Wesley A. Olmsted
  • Patent number: 7161024
    Abstract: In its several embodiments, this invention discloses a novel process to prepare the compounds of Formula 3: wherein R1 is lower alkyl, and R2 and R3 can be the same or different, each being independently selected from the group consisting of alkyl, aryl and aralkyl; said process being carried out in a suitable solvent with at least one tert-amine carboxylate salt catalyst. The compounds of formula 3 are chemical intermediates useful for the synthesis of various heterocyclic compounds. These heterocyclic compounds are in turn useful precursors for diverse pharmaceutical, herbicidal and insecticidal agents. In particular, these intermediates are useful precursors to a variety of CCR5 inhibitors.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: January 9, 2007
    Assignee: Schering Corporation
    Inventor: Richard W. Draper
  • Patent number: 7161025
    Abstract: The present invention provides a method for producing industrially useful fluorine-containing compounds such as a fluorinated ester compound and an acid fluoride compound. Namely, the present invention resides in a method for producing a fluorinated ester compound, which comprises fluorinating an ester compound which is an ester of a compound having hydroxyl group(s) with a compound having acyl fluoride group(s) and which has a structure which can be fluorinated, in a liquid phase to produce a fluorinated ester compound, wherein the fluorination is carried out in the form of a liquid mixture of the ester compound and the compound having acyl fluoride group(s).
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: January 9, 2007
    Assignee: Asahi Glass Company, Limited
    Inventors: Takashi Okazoe, Kunio Watanabe, Shin Tatematsu, Koichi Yanase, Yasuhiro Suzuki, Daisuke Shirakawa
  • Patent number: 7161026
    Abstract: A process for producing phenylacetic acid is provided. The process includes combining sodium, chlorobenzene, toluene, and a catalyst to form a suspension. This suspension is mixed to form phenylsodium. Upon boiling, the suspension forms benzylsodium. The suspension is then carbonized and acidified to form phenylacetic acid.
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: January 9, 2007
    Assignee: Property Development Corporation International, Ltd, Inc.
    Inventors: Alimamed Latif Shabanov, Elmira Mamedem Ramazanova
  • Patent number: 7161027
    Abstract: Disclosed is a process to produce a purified carboxylic acid slurry. The process comprises removing impurities from a crystallized product in a solid liquid displacement zone to form the purified carboxylic acid slurry. The purified carboxylic acid slurry is further cooled in a cooling zone and subsequently filtered and dried in a filtration and drying zone. The process produces purified carboxylic acid product having good color and low impurity levels without the use of purification steps like hydrogenation or filtrate purge.
    Type: Grant
    Filed: August 21, 2003
    Date of Patent: January 9, 2007
    Assignee: Eastman Chemical Company
    Inventors: Ronald Buford Sheppard, Brent Alan Tennant, Thomas Earl Woodruff, Robert Lin
  • Patent number: 7161028
    Abstract: The invention concerns a method for producing acrylic acid from propane in the absence of molecular oxygen. Said method is characterized in that it consists in passing a gas mixture free of molecular oxygen and comprising propane, water vapour, as well as, optionally, an inert gas, over a catalyst including molybdenum, vanadium, tellurium, oxygen and at least another element X selected among niobium, tantalum, tungsten, titanium, aluminium, zirconium, chromium, manganese, iron, ruthenium, cobalt, rhodium, nickel, palladium, platinum, antimony, bismuth, boron, indium and cerium, and on a co-catalyst of formula (II): Mo1Bia?Feb?Coc?Nid?Ke?Sbf?Tig?Sih?Cai?Nbj?Tek?Pbl?Wm?Cun?. The invention also concerns a solid catalytic composition comprising said catalyst and co-catalyst and the use of said composition for producing acrylic acid from propane.
    Type: Grant
    Filed: November 28, 2002
    Date of Patent: January 9, 2007
    Assignee: Arkema France
    Inventors: Jean-Luc Dubois, Stephanie Serreau, Julien Jacquel
  • Patent number: 7161029
    Abstract: A diL-lysine monosulfate trihydrate crystal which has a large tabular form and is more easily separable from the mother liquor. The crystal is obtained by a novel process of conducting crystallization at a lower temperature.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: January 9, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takeshi Kushiku, Dave Steckelberg, Toshiya Tanabe, Jirou Haga
  • Patent number: 7161030
    Abstract: Hydrofluoroethers of formula: T-CFX?—O—Rf—CFX-T???(II) wherein: T=CH3; X, X?, equal to or different from each other, are selected between F, CF3; T00?=F, Cl, H, C1–C3 perfluoroalkyl, CH3, CH2OH, COCl, CHO, CO2H; Rf is a perfluoroalkylene or a perfluoropolyoxyalkylene and respective preparation process by reduction with hydrogen in the presence of a platinum catalyst supported on metal fluorides of the corresponding compounds with at least one —COCl end group.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: January 9, 2007
    Assignee: Solvay Solexis S.p.A.
    Inventors: Rosaldo Picozzi, Antonella Di Meo, Claudio Tonelli
  • Patent number: 7161031
    Abstract: Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: Ar, X, X1, g, R and R3 are as defined herein.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: January 9, 2007
    Assignees: Temple University - Of The Commonwealth System of Higher Education, Onconova Therapeutics, Inc.
    Inventors: E. Premkumar Reddy, M.V. Ramana Reddy, Stanley C. Bell
  • Patent number: 7161032
    Abstract: Sulfonamide derivatives represented by general formula (I) or salts thereof; insecticides for agricultural and horticultural use containing the same as the active ingredient; and usage thereof: [wherein A is optionally substituted (C1–C6)alkylene, (C3–C6)alkenylene or the like; R1 is H, optionally substituted (C1–C6)alkyl, (C3–C6)alkenyl, (C3–C6)cycloalkyl or the like; R2, R3 and R4 are each H, (C1–C6)alkyl, (C3–C6)alkenyl or the like, or R2 and A or R2 and R1 may form a 3- to 8-membered ring which may be interrupted by one to three atoms selected from among O, S and N; Q is C or N; X and Y are each halogen, CN, NO2, (C1–C6)alkyl, (C2–C6)alkenyl or the like; m is 0 to 2; n is 0 to 3; and two adjacent Xs or Ys on the aromatic ring may be united to form a fused ring]. The compounds exhibit excellent insecticidal activity against insect pests resistant to existing pesticides even when applied in dosages lower than those of similar pesticides.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: January 9, 2007
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Minoru Yamaguchi, Hayami Nakao, Makoto Goto, Masayuki Morimoto, Shinsuke Fujioka, Masanori Tohnishi
  • Patent number: 7161033
    Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: January 9, 2007
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Raj Nagarajan, David L. Brown, Joseph J. McDonald
  • Patent number: 7161034
    Abstract: Lidocaine analogs, latex particle-analog conjugates, and methods of making and using the same. The analogs have the formula: wherein Z comprises a nucleophilic group and optionally a protecting group; L is a linker; R1, R2, R3, R4, R5 are each independently H, a protecting group, or C1 to C6 alkyls, provided that R1 and R3 may form a six membered ring with the nitrogen and carbon atom to which R1 and R3 are attached; R6 and R7 are each independently H or C1 to C20 alkyls; and including salts thereof. The analogs are immobilized on latex particles and prepared for use in assays for lidocaine.
    Type: Grant
    Filed: April 20, 2004
    Date of Patent: January 9, 2007
    Assignee: Dade Behring Inc.
    Inventors: Victor P. Chu, Zhu Teng, Sandra Lewisch, Ronald L. Edwards
  • Patent number: 7161035
    Abstract: The invention relates to compounds of formula (I): wherein: B represents a hydrogen atom, a COOR group, a CONRR? group, or a (C1–C6)alkyl group substituted by a COOR, CONRR? or OR group, G1 represents a —X?—(CH2)n—X—(CH2)m—X?— chain wherein X, X?, X?, n and m are as defined in the description, Cy represents a grouping of formula (II) or (III): G2 represents an alkylene chain as defined in the description, and A represents a NRCOR?, NRCSR?, CONRR?, CSNRR?, NRCONR?R? or NRCSNR?R? group.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: January 9, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Carole Descamps-Francois, Said Yous, Daniel Lesieur, Gérald Guillaumet, Marie-Claude Viaud, Hervé Da Costa, Caroline Bennejean, Philippe Delagrange, Pierre Renard
  • Patent number: 7161036
    Abstract: A process for producing an oxime is provided, wherein the process comprises the step of reacting a ketone, hydrogen peroxide and ammonia in the presence of a crystalline titanosilicate having MWW structure under the condition that the ammonia concentration in the liquid portion of the reaction mixture is about 1% by weight or more. By the process, an ammoximation reaction of the ketone can be carried out with a high conversion of the ketone and a high selectivity to the oxime corresponding to the ketone, thereby producing the oxime with a high yield.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: January 9, 2007
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Miyuki Oikawa, Masami Fukao
  • Patent number: 7161037
    Abstract: The invention relates to a process for preparing nitric acid by treating an aqueous medium containing organic compounds and phosphate, said process comprising: feeding the aqueous medium to a nitric acid synthesis zone; forming nitric acid by contacting the aqueous medium with a gaseous medium in said nitric acid synthesis zone, said gaseous medium containing NO2; discharging an off-gas from said nitric acid synthesis zone; wherein the total organic carbon concentration in the aqueous medium entering the nitric acid synthesis zone is less than 0.03 wt. %.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: January 9, 2007
    Assignee: DSM IP Assets B.V.
    Inventors: Arno Herald Benneker, Hendrik Oevering, Johannes Antonius Leonardus Brouwers
  • Patent number: 7161038
    Abstract: The present invention is a process for producing polyoxyalkylene triamine by bringing polyoxyalkylene triol having at its terminal a hydroxyl group into contact with ammonia and hydrogen in the presence of a catalyst comprising ruthenium metal at an amount of 0.5 to 20% by weight of the total of the catalyst, the ruthenium metal being carried on at least one carrier selected from alumina, silica, silica-alumina, titanium dioxide, and titanium dioxide-silica.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: January 9, 2007
    Assignee: Kao Corporation
    Inventors: Tetsuaki Furushima, Masaharu Jono
  • Patent number: 7161039
    Abstract: A process for preparing ethylamines, butylamines and mixed ethyl/butylamines comprising the following steps: (i) Hydroamination of butadiene and ethylene by means of a monoalkylamine and/or a dialkylamine in which alkyl=ethyl and/or butyl in the presence of an alkali metal amide as catalyst, (ii) isomerization of the amines obtained in the hydroamination (i), if appropriate under the following conditions: (iia) prior fractionation into particular fractions and/or (iib) isomerization under hydrogenating conditions and/or (iic) isomerization in the presence of ammonia, (iii) fractionation of the resulting product mixture with isolation of the desired product amines and recycle of the amines suitable as starting material to step (i).
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: January 9, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulrich Steinbrenner, Frank Funke, Ralf Böhling
  • Patent number: 7161040
    Abstract: This invention relates to an improved method for making unsubstituted carborane anions and monosubstituted carborane anions of formula: (R—CBn—Hm?)? where n is an integer ranging from 5 to about 11 and m? is an integer ranging from 5 to 16 where the relative values of n and m? depend upon the exact structure of the carborane and the presence of a non-hydrogen substituent. m as used herein is an integer ranging from 5 to 16. When R is hydrogen the anion is unsubstituted. When R is a halogen, a phenyl, a substituted phenyl group, such as fluorophenyl group, or any other substituent, the carborane is substituted. The method is particularly useful for preparation of twelve-vertex carborane anions R—CB11H11?, where R is a defined above, and is specifically useful for preparation of the unsubstituted carborane CB11H12-??, where R is H.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: January 9, 2007
    Assignee: The Board of Regents of the University and Community College System of Nevada on Behalf of the University of Nevada Reno
    Inventors: Andreas Franken, Benjamin T. King, Josef Michl
  • Patent number: 7161041
    Abstract: The present invention provides a process for producing 2-(1-hydroxyalkyl)cycloalkanone and/or 2-(1-hydroxyaryl)cycloalkanone in high yield and selectivity, as well as a process using the same to produce a cycloalkanone derivative useful as a perfume material and a physiologically active substance. Disclosed is a process for producing compound (3), which includes subjecting a cycloalkanone, and aldehyde (2) containing carboxylic acid (1), to aldol condensation in the presence of water and a basic catalyst, wherein the molar amount (referred to hereinafter as A) of the basic catalyst added is not less than the molar amount (referred to hereinafter as B) of the carboxylic acid (1) contained in the aldehyde (2) and the difference between A and B, that is, (A?B) is 0.06 mol or less per mol of the aldehyde (2), as well as a process for producing compounds (7) and (8) by using the compound (3) obtained by the above process.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: January 9, 2007
    Assignee: Kao Corporation
    Inventors: Koji Mine, Kimikazu Fukuda
  • Patent number: 7161042
    Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; and (CH2)nOR? wherein n is an integer from 1 to 3 and R? represents a C6–C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; B is selected from OR? and NHR? wherein R? is C1–C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: January 9, 2007
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Derek Wyndham Clissold, Stuart Wilbert Craig, Rajendrakumar Reddy Gadikota, Min He, Jurjus Fayez Jurayj, Shahrokh Kazerani, Erwin Rannala, Pradeep Kumar Sharma
  • Patent number: 7161043
    Abstract: Process for the carbonylation of optionally substituted ethylenically unsaturated compounds by reaction with carbon monoxide and a coreactant in the presence of a catalyst system. The catalyst system includes (a) a source of Pt group metal cations, (b) a certain bidentate diphosphine composition.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: January 9, 2007
    Assignee: Shell Oil Company
    Inventor: Eit Drent
  • Patent number: 7161044
    Abstract: An object of the present invention is to provide a catalytic gas phase oxidation reaction in which: even under reaction conditions of a higher gas pressure, a higher concentration of the raw material gas and a larger space velocity of a reaction gas, the thermal accumulation at the hot spot portion can be sufficiently suppressed with ease and at low costs, so that the reaction can be continued for a long time while a high yield is maintained.
    Type: Grant
    Filed: October 4, 2004
    Date of Patent: January 9, 2007
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Daisuke Nakamura, Michio Tanimoto
  • Patent number: 7161045
    Abstract: A process of manufacture of polytrimethylene ether glycol comprising: (a) polycondensing reactant comprising diol selected from the group consisting of 1,3-propanediol, 1,3-propanediol dimer and 1,3-propanediol trimer or mixtures thereof in the presence of acid polycondensation catalyst to form polytrimethylene ether glycol; (b) adding water to the polytrimethylene ether glycol and hydrolyzing the acid esters formed during the polycondensation to form a hydrolyzed mixture containing the polytrimethylene ether glycol and the hydrolyzed acid esters; (c) adding organic solvent that is miscible with water to the hydrolyzed mixture to form an aqueous-organic mixture comprising (i) organic phase containing polytrimethylene ether glycol and residual acid polycondensation catalyst from the polycondensing and (ii) water phase; (d) separating the water phase and the organic phase; (e) adding base to the separated organic phase to neutralize the residual acid polycondensation catalyst by forming salts of the residual ac
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: January 9, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Hari Babu Sunkara, Howard C. Ng, Wei Zheng
  • Patent number: 7161046
    Abstract: Disclosed is a process for the preparation of alkylene glycols from the corresponding alkylene oxide, such as ethylene glycol from ethylene oxide, in the presence of water, a catalyst and, optionally, carbon dioxide. The catalyst is a SALEN-type compound which contains an amino group and an oxy or hydroxy group connected by a hydrocarbon, such as an alkyl or an alkylaryl. The SALEN-type compounds may be Schiff bases, i.e., a condensate product of a primary amine with an aldehyde, ketone or an alcohol. The SALEN-type compound may be a mono or bis compound and may be complexed with a Group 4-14 metal, such as aluminum, tin, vanadium, chromium, manganese, iron, cobalt or platinum.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: January 9, 2007
    Assignee: Saudi Basic Industries Corporation
    Inventors: Jaap W. Van Hal, John S. Ledford, Xiankuan Zhang
  • Patent number: 7161047
    Abstract: A process for preparing a secondary alcohol which is characterized in adding a primary or a secondary amine in the reaction system in case that the secondary alcohol is prepared by hydrogenating in the presence of a noble metal, an epoxy derivative represented by the following formula, wherein R1 and R2 are the same or different, an organic group not containing aldehyde group or ketone group therein or hydrogen atom, provided that both R1 and R2 are not simultaneously hydrogen atom.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: January 9, 2007
    Assignee: Daiso Co., Ltd.
    Inventors: Yasushi Miki, Daisuke Fukumoto, Masafumi Mikami
  • Patent number: 7161048
    Abstract: Methanol is produced from bacterially oxidized waste methane by reaction with Pd+2, Cu+2, air, and molten phthalic anhydride in an entrained oxidizer generating half ester of methyl phthalate which is reaction distilled to produce methanol and recycle phthalic anhydride containing the Pd+2, Cu+2 phthalate catalyst.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: January 9, 2007
    Assignee: Rinnovi, L.L.C.
    Inventors: Carol Knox, legal representative, Walter R. Knox, deceased
  • Patent number: 7161049
    Abstract: A process is disclosed for purifying a hydrofluoropropane of undesirable C2–C4 olefinic and C1–C4 saturated chlorinated impurities, comprising the steps of: contacting a first mixture of hydrofluoropropane, olefinic impurity and saturated chlorinated impurity with hydrogen and hydrogen fluoride concurrently in the presence of a bifunctional catalyst, for example an alloy of gold and palladium supported on carbon, capable of catalyzing hydrogenation and fluorination. During the contacting step, olefinic impurity is converted to saturated hydrogenated derivative and/or saturated hydrofluorinated derivative, and saturated chlorinated impurity is converted to a saturated hydrodechlorinated derivative and/or saturated fluorinated derivative. The hydrofluoropropane thus formed is substantially free of both the olefinic and saturated chlorinated impurities and may be used as obtained or subject to further purification steps such as distillation to remove the process derivatives (e.g.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: January 9, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Velliyur Nott Mallikarjuna Rao, Allen C. Sievert
  • Patent number: 7161050
    Abstract: A reactant selected from the group consisting of alkanes, alkenes, alkynes, dienes, and aromatics is reacted with a halide selected from the group including chlorine, bromine, and iodine to form a first reaction product. The first reaction product is reacted with a solid oxidizer to form a product selected from the group including olefins, alcohols, ethers, and aldehydes, and spent oxidizer. The spent oxidizer is oxidized to form the original solid oxidizer and the second reactant which are recycled.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: January 9, 2007
    Assignees: GRT, Inc., The Regents of the University of California
    Inventors: Jeffrey H. Sherman, Eric W. McFarland, Michael J. Weiss, Ivan Marc Lorkovic, Leroy E. Laverman, Shouli Sun, Dieter J. Schaefer, Galen Stucky, Peter Ford
  • Patent number: 7161051
    Abstract: Disclosed is a process for producing light olefins in an integrated methanol synthesis/MTO reaction system. The integrated system implements a shared separation system for separating oxygenate components from the respective methanol synthesis system and MTO reaction system. By providing a shared separation system, the number of separation units in an integrated methanol/MTO reaction system may be advantageously reduced.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: January 9, 2007
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventor: Cor F. Van Egmond
  • Patent number: 7161052
    Abstract: A process is described for the valorization of a charge of hydrocarbons and for reducing the vapour pressure of said charge, comprising three steps: a step a) consisting of separating said charge of hydrocarbons into a fraction (O1) comprising essentially compounds containing 5 carbon atoms, including at least 2% by weight of pentenes, a step b) consisting of placing said fraction (O1) in contact with a cut of hydrocarbons (O2) at least partly comprising hydrocarbons having a number of carbon atoms between 6 and 10, including at least 2% by weight of olefins, and a step c) consisting of separating the effluents originating from step b) into a gasoline cut (?) the upper distillation point of which is less than 100° C. and a kerosene cut (?) having a distillation range between 100° C. and 300° C.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: January 9, 2007
    Assignee: Institut Francais de Petrole
    Inventors: Patrick Briot, Vincent Coupard, Alain Forestiere, Eric Llido, Thierry Poussereau