Abstract: Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.

Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.

Abstract: Processes for preparing carboxylic acids and derivatives thereof in which an ammonium salt of the carboxylic acid is heated in the presence of an organic reagent to split the salt and form the acid or, where the organic reagent is an esterifying agent, the corresponding ester. Both the acid and the ester may be dehydrated to form unsaturated counterparts.

Abstract: The present invention relates to a process for the preparation of di- and polyamines of the diphenylmethane series, and to the preparation of di- and poly-isocyanates of the diphenylmethane series from these di- and poly-amines. The di- and poly-amines of the diphenylmethane series are prepared by the reaction of aniline and formaldehyde in the presence of hydrochloric acid. In with the present invention, the hydrochloric acid employed contains less than 0.001 wt. % of metal ions which are divalent and/or more than divalent.

Abstract: The present invention provides a safe, convenient and efficient method for producing carboxylic acid by a reaction of alicyclic alcohol with an aqueous hydrogen peroxide to thereby obtain carboxylic acid in high yield from alicyclic alcohol or alicyclic ketone under mild reaction conditions, wherein the reaction operation is simple and easy, a step for removing solvent after completion of the reaction is not necessary and influence and toxicity upon the environment and human body are markedly small. In order to provide it, an oily alicyclic alcohol is allowed to react with an aqueous hydrogen peroxide in the presence of a catalyst containing a metal compound belonging to Group 6 of the Periodic Table in a heterogeneous solution system.

Abstract: The present invention is directed to the use of compounds of the formula: for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches.

Abstract: Process for the preparation of 2-[(diphenylmethyl)thioacetamide, an intermediate for the preparation of Modafinil which is a CNS stimulant and used for the treatment of narcolepsia. The process comprises reacting 2-[(diphenylmethyl)thio]acetic acid with alcohols, in presence of catalytic amount of inorganic acid or organic acid at reflux temperature of alcohol to obtain corresponding ester which is reacted with ammonia to give 2-[(diphenylmethyl)thio]acetamide. If desired 2-[(diphenylmethyl)thioacetamide thus produced is reacted with hydrogen peroxide to produce Modafinil.

Abstract: Z-substituted acrylamides of formula (I), where the substituents have the following meanings: X?H, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, with X in the 3- or 4-position, n=1 or 2, where X can be different if n=2, R1=alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, aziridine and oxirane and R2?H, alkyl, haloalkyl, allyl, propargyl or CH2C?C-alkyl. Methods for production thereof, agents comprising the above and the use thereof for the treatment of plant-pathogenic fungal pests.

Abstract: The present invention relates to novel microbicidal compositions based on biphenylbenzamide derivatives of the formula (I) in which R1, R2, R3 and m are as defined in the disclosure, to novel biphenylbenzamides, to a plurality of processes for preparing these substances and their use for controlling pests, and to novel intermediates and processes for their preparation.

Abstract: An acid salt of sertraline, wherein the acid is citric acid, fumaric acid, malic acid, maleic acid, malonic acid, phosphoric acid, succinic acid, sulfuric acid, L-tartaric acid, HBr, acetic acid, benzoic acid, benzenesulfonic acid, ethanesulfonic acid, lactic acid, methanesulfonic acid or toluenesulfonic acid. Similarly, a solvate of sertraline HCl, wherein the solvent is methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, t-butanol, acetic acid, ethyl acetate, or propylene glycol.

Abstract: A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Abstract: An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula 4 is produced by a process including (a) reacting an optically active secondary amine, represented by the formula 1, with an alkylation agent R2—X, in the presence of a base, thereby converting the secondary amine into an optically active tertiary amine represented by the formula 3; and (b) subjecting the tertiary amine to a hydrogenolysis, thereby producing the N-monoalkyl derivative, wherein R represents a fluorine atom, trifluoromethyl group or trifluoromethoxy group, n represents an integer of from 1 to 5, each of R1 and R2 independently represents an alkyl group having a carbon atom number of from 1 to 6, Me represents a methyl group, Ar represents a phenyl group or 1- or 2-naphthyl group, * represents a chiral carbon, and X represents a leaving group.

Abstract: Products from the decomposition of cumene hydroperoxide (CHP) are recovered by distillation. The majority of the undesirable by-product acetol (hydroxyacetone) is removed from the phenol stream by distillation wherein the majority of the acetol is carried with an overheads stream comprising acetone, cumene and alphamethylstyrene (AMS). Acetol is subsequently separated from acetone by distillation wherein acetone is taken as an overheads stream and acetol remains with a bottoms stream comprising cumene, AMS and phenol. The acetol, along with residual phenol, is extracted from the cumene and AMS by counter-current washing with an aqueous alkali metal hydroxide. The phenol stream is then distilled to separate phenol from cumene, alphamethylstyrene and higher boiling compounds. The phenol, containing only a small amount of acetol, can then be treated to remove methylbenzofuran by treatment with an acidic resin or solid superacid catalyst without formation of significant amounts of additional methylbenzofuran.

Abstract: Process for preparing polyether polyols having an end block of ethylene oxide by addition of alkylene oxides onto H-functional starter substances, in which A) a polyether polyol precursor is prepared by means of double metal cyanide (DMC) catalysis in a semicontinuous mode of operation in which previously prepared polyether polyol together with the DMC catalyst are placed in a reactor and H-functional starter substance and propylene oxide are added continuously, B) the polyether polyol precursor from stage A) is reacted with propylene oxide or an ethylene oxide/propylene oxide mixture in the presence of the DMC catalyst in a continuously operating reactor to give a polyether polyol intermediate, C) the intermediate from stage B) is mixed with an alkali metal hydroxide as catalyst and D) reacted with ethylene oxide in a continuously operating reactor to give the final product, E) the catalyst is separated off from the final product obtained in stage D).

Abstract: The invention pertains to a hydroformylation process for the conversion of an ethylenically unsaturated compound to an alcohol comprising a first step of reacting at an elevated temperature in a reactor the ethylenically unsaturated compound, carbon monoxide, hydrogen, and a phosphine-containing cobalt hydroformylation catalyst, which are dissolved in a solvent, followed by a second step of separating a mixture comprising the alcohol and heavy ends from a solution comprising the catalyst and the solvent, followed by a third step of recycling the solution to the reactor.

Abstract: A process for removing one or more unsaturated halocarbons from a halocarbon mixture comprising one or more unsaturated halocarbons and one or more saturated halocarbons, which process comprises contacting the halocarbon mixture with a mixture of a solid chemical oxidant and a solid support in the presence of water.

Abstract: The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of the formulae (Ia), (Ib) and (Ic) or a mixture thereof: wherein R1, R2, R3, R4, and R5 are defined herein. Compounds of formulae (Ia), (Ib) and (Ic) or mixtures thereof are useful in the preparation of compounds of formula (II): wherein R2, R3 and R6 are also defined herein.

Abstract: Aromatization of alkanes having one to four carbon atoms per molecule to aromatics, such as benzene, toluene and xylenes (BTX), uses a catalyst of a crystalline zeolite on which platinum has been deposited, specifically a platinum-containing ZSM-5. A byproduct of the process is a light gas fraction of methane and ethane. The use of a platinum-containing ZSM-5 catalyst in an alkane aromatization process, such as the Cyclar process, suppresses the formation of methane and increases selectivity to BTX. The high content of ethane relative to methane in the light gas fraction allows this process effluent to be a feedstream for a cracker.

Abstract: A catalyst of a gallium zeolite on which platinum (Pt/Ga-ZSM-5) has been deposited may be used for aromatization of alkanes having two to six carbon atoms per molecule, such as ethane, propane, butane, etc., to aromatics, such as benzene, toluene and xylenes (BTX). The gallium zeolite contains gallium and silicon in the framework of the zeolite structure. The zeolite structure may be of MFI, FAU, TON, MFL, VPI, MEL, AEL, AFI, MWW or MOR, but preferably, the zeolite has a MFI structure, more preferably is ZSM-5 MFI zeolite. According to the IUPAC recommendations, an example of the sodium form of the zeolite would be represented as: |Nax·(H2O)z|[GaxSiyO2y+3x/2]?MFI where x=0.1–25; y=60–100; and z=0.1–10. Platinum may be deposited on the gallium zeolite by ion exchange or impregnation.

Abstract: A process is provided for the production of xylenes from reformate by reactive distillation. The process is carried out by methylating the benzene/toluene present in the reformate in a reactive distillation zone and under reactive distillation conditions to produce a resulting product having a higher xylenes content than the reformate. Greater than equilibrium amounts of para-xylene can be produced by the process.

Abstract: Sulphur-containing olefinic feedstocks are oligomerized over zeolite catalysts.

Abstract: A process is described for converting an oxygenate-containing feedstock into one or more olefins in a reactor system including a plurality of fixed bed reactors each containing a catalyst composition comprising a molecular sieve and at least one metal oxide having an uptake of carbon dioxide at 100° C. of at least 0.03 mg/m2 of the metal oxide. Each reactor is sequentially rotated between at least one operating mode, wherein the catalyst composition in the reactor is contacted with the oxygenate-containing feedstock, and a regeneration mode, wherein the catalyst composition in the reactor is contacted with a regeneration medium.

Abstract: A process to prepare a process oil with an aromatic content of more than 50 wt % (according to ASTM D 2007) and a polycyclic aromatics (PCA) less than 3 wt % (according to IP 346) by (a) contacting a feed mixture of a petroleum fraction boiling in the lubricating oil range and an aromatic rich hydrocarbon fraction with a polar solvent in a counter-current liquid-liquid extraction column, wherein the process oil is obtained by removing the polar solvent from the top product and an extract is obtained by removing the polar solvent from the top product and an extract is obtained by removing the polar solvent from the bottom product.

Abstract: Methods and systems for processing vesicants as well as other irritants are described. In some methods a vesicant, for example, a Lewisite such as the L1 form, the L2 form, L3 form, or combination thereof, is combined with permanganate, for example, as an aqueous solution of sodium permanganate. The methods can include releasing the vesicants or irritants from a munition, for example, by explosively rupturing the munition.

Abstract: A method for moving a first epidermal area relative to a second epidermal area using a plurality of adhesive coated anchoring structures and an elastic material, the elastic material being coupled to the anchor structures.

Abstract: The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify CAR ligands, including compounds that modulate CAR receptor activity, compounds likely to have CAR-mediated toxicity, and analogs of these compounds with less potential toxicity.

Abstract: The present invention provides an adult T cell leukemia model animal, which is a T cell function deficient animal to which a cell line infected with human T cell leukemia virus-1 is transplanted. This model animal allows the HTLV-1 infected cell line to proliferate over a long period of time, and enables not only the tumorigenesis process but also the mechanism of onset of ATL and immune response mechanism of the host against ATL to be precisely analyzed.

Abstract: The construction of transgenic animal models of human Alzheimer's disease, and methods of using the models to screen potential Alzhe## disease therapeutics, are described. The models are characterized by pathologies similar to pathologies observed in Alzheimer's disease, based on expression of all three forms of the ?-amyloid precursor protein (APP), APP695, APP751, and APP770, as well as various point mutations based on naturally occurring mutations, such as the London and Indiana familial Alzheimer's disease (FAD) mutations at amino acid 717, predicted mutations in the APP gene, and truncated forms of APP that contain the A? region. Animal cells can be isolated from the transgenic animals or prepared using the same constructs with standard techniques such as lipofection or electroporation.

Abstract: A transgenic mouse whose genome comprises a transcriptional control region operably linked to a cDNA encoding calreticulin (CRT) is described.

Abstract: The present invention relates to the use of leukemia inhibitory factor (LIF) in the isolation and propagation of embryonic stem cells in vitro.

Abstract: Disclosed are isolated ?-amyrin synthase-encoding cDNA and genomic nucleic acids, which are involved in saponin synthesis. Also provided are complementary sequences, vectors, transformed host cells, transformed plants, and methods for influencing or affecting triterpene synthesis, and hence resistance to a fungal pathogen of a plant using ?-amyrin synthase encoding nucleic acids.

Abstract: This invention relates to an isolated nucleic acid fragment encoding a viral movement protein. The invention also relates to the construction of a chimeric gene encoding all or a substantial portion of the viral movement protein, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the viral movement protein in a transformed host cell.

Abstract: A protein which has an amino acid sequence shown by SEQ ID NO: 2, 4, 6, 23, 25, 27 or 29, or any of these amino acid sequences modified, and which has activity for transferring an aliphatic acyl group to a glycosyl group at the 5-position of flavonoids, and a gene encoding the same.

Abstract: An isolated polynucleotide encoding a full-length rice cap binding protein 80 (CBP80) is provided. The reduction in expression or activity of CBP80 in a transgenic rice plant cell may be accomplished by antisense sequences which can inhibit expression or activity of endogenous CBP80 in a rice plant cell which may lead to alterations in hormone signaling.

Abstract: The invention relates to isolated genes encoding polypeptides that interact with calreticulin (CRT), plants and plant cells transformed with the CRT genes for resistance against cold stress, and methods of producing the transformed plants and cells.

Abstract: The invention refers to a method to transform and obtain plants of woody trees, particularly Eucalyptus spp., transformed by the introduction of exogenous genes of interest into their cells. The method makes use of sterilized seeds, which are co-cultivated with Agrobacterium cells containing a transference plasmid (tDNA), and any gene of interest. The method used for the transformation employs sonication to increase the efficiency of bacteria penetration within teguments and seed embryo tissues.

Abstract: This invention relates to an isolated nucleic acid fragment encoding a serine O-acetyltransferase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of the serine O-acetyltransferase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the serine O-acetyltransferase in a transformed host cell.

Abstract: The invention features plant cells and plants that include a nucleic acid molecule encoding a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned homologous domain. The chimeric isoprenoid synthases of the invention catalyze the production of isoprenoid reaction products that are not produced when the asymmetrically positioned homologous domain is positioned at its naturally-occurring site in an isoprenoid synthase polypeptide.

Abstract: Sedoheptulose 1,7-bisphosphatase (SBPase) is an enzyme catalyzing the reaction converting sedoheptulose 1,7-bisphosphate into sedoheptulose 7-phosphate. This enzyme is located in the chloroplast in leaves and stems. Overexpression of SBPase in transgenic plants is provided to improve plant yield by increasing leaf starch biosynthetic ability in particular and sucrose production in general. Deregulated variants of the enzymes are also provided.

Abstract: Disclosed are transgenic plants, seeds, and progeny from such plants comprising a cryET29 DNA segment. The cryET29 DNA segment encodes CryET29 crystal protein which comprises SEQ ID NO:2 and exhibits insecticidal activity against siphonapteran insects, including larvae of the cat flea (Ctenocephalides felis), as well as against coleopteran insects, including the southern corn rootworm (Diabrotica undecimpunctata), western corn rootworm (D. virgifera), Colorado potato beetle (Leptinotarsa decemlineata), Japanese beetle (Popillia japonica), and red flour beetle (Tribolium castaneum).

Abstract: The present invention is in the field of soybean variety S05-97016-G99-21212 breeding and development. The present invention particularly relates to the soybean variety S05-97016-G99-21212 and its progeny, and methods of making S05-97016-G99-21212.

Abstract: A soybean cultivar designated CL727422 with high yield potential and tolerance to Roundup™ herbicide, further including the plants and seeds of the cultivar CL727422, methods for producing a soybean plant by crossing the cultivar CL727422 with itself or another soybean plant. The invention also relates to soybean cultivar CL727422 further comprising one or more single gene traits, and to methods of producing a soybean having such traits by introgression, transformation or mutagenesis. The invention also includes using the soybean cultivar CL727422 to produce other soybean cultivars, breeding lines, and progeny.

Abstract: According to the invention, there is provided a novel soybean variety designated XB29R06. This invention thus relates to the seeds of soybean variety XB29R06, to the plants of soybean XB29R06 to plant parts of soybean variety XB29R06 and to methods for producing a soybean plant produced by crossing plants of the soybean variety XB29R06 with another soybean plant, using XB29R06 as either the male or the female parent.

Abstract: A cotton cultivar, designated 02X25R, is disclosed. The invention relates to the seeds of cotton cultivar 02X25R, to the plants of cotton 02X25R and to methods for producing a cotton plant produced by crossing the cultivar 02X25R with itself or another cotton variety. The invention further relates to hybrid cotton seeds and plants produced by crossing the cultivar 02X25R with another cotton cultivar.

Abstract: Nucleic acid molecules are described encoding a starch granule-bound protein from maize as well as methods and recombinant DNA molecules for the production of transgenic plant cells and plants synthesizing a modified starch. Moreover, the plant cells and plants resulting from those methods as well as the starch obtainable therefrom are described.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated I918166. This invention thus relates to the plants, seeds and tissue cultures of the variety I918166, and to methods for producing a corn plant produced by crossing a corn plant of variety I918166 with itself or with another corn plant, such as a plant of another variety. This invention further relates to corn seeds and plants produced by crossing plants of variety I918166 with plants of another variety, such as another inbred line, and to crosses with related species. This invention further relates to the inbred and hybrid genetic complements of plants of variety I918166, and also to the SSR and isozyme typing profiles of corn variety I918166.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated I156024. This invention thus relates to the plants, seeds and tissue cultures of the variety I156024, and to methods for producing a corn plant produced by crossing a corn plant of variety I156024 with itself or with another corn plant, such as a plant of another variety. This invention further relates to corn seeds and plants produced by crossing plants of variety I156024 with plants of another variety, such as another inbred line, and to crosses with related species. This invention further relates to the inbred and hybrid genetic complements of plants of variety I156024.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated LH249. The invention thus relates to the plants, seeds and tissue cultures of the variety LH249, and to methods for producing a corn plant produced by crossing a corn plant of variety LH249 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety LH249 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety LH249.

Abstract: An inbred maize line, designated PH0GC, the plants and seeds of inbred maize line PH0GC, methods for producing a maize plant, either inbred or hybrid, produced by crossing the inbred maize line PH0GC with itself or with another maize plant, and hybrid maize seeds and plants produced by crossing the inbred line PH0GC with another maize line or plant and to methods for producing a maize plant containing in its genetic material one or more transgenes and to the transgenic maize plants produced by that method. This invention also relates to inbred maize lines derived from inbred maize line PH0GC, to methods for producing other inbred maize lines derived from inbred maize line PH0GC and to the inbred maize lines derived by the use of those methods.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated I029010. The invention thus relates to the plants, seeds and tissue cultures of the variety I029010, and to methods for producing a corn plant produced by crossing a corn plant of variety I029010 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety I029010 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety I029010.