Abstract: The device enables a second drop to be mixed in a first drop deposited on an electrically insulating layer of an analysis support, in a viscous liquid environment and to mix the resulting drop. The device comprises at least one injector forming the second drop above the first drop. After formation of the second drop, a voltage impulse is applied between a first electrode, arranged under the electrically insulating layer of the analysis support, underneath the first drop, and a second electrode arranged near the outlet orifice of the injector. The voltage impulse fosters the coalescence phenomenon between the two drops, while preventing risks of contamination of the injector by the reagent of the first drop.

Abstract: Laboratory device design particularly for a multiplate format that includes a plate or tray having a plurality of wells, and a drain in fluid communication with each of the plurality of wells. The plate is a one-piece design having a honeycomb structure that brings high rigidity to the plate in order to accept very high centrifugal load. The design also maximizes the well volume and active filtration area while remaining in compliance with SBS format.

Abstract: The present invention provides a simple, inexpensive apparatus for and method of capturing biological or other material from sample suspensions on a collection surface and for depositing captured material on a receiving surface, such as a microscope slide, for observation and analysis. Accordingly, cytological material may be deposited in near mono-layers for the detection of disease. In one embodiment of the present invention, density gradients of material are captured and deposited, thus providing a desired range of concentrations for examination. In another embodiment multiple depositions or multiple slides may be made from the same sample suspension. The method and apparatus to exploit this new method are both presented for various applications. The dimensions of material captured and deposited may be controlled and used in conjunction with microscope slides that confine material to specific regions of interest.

Abstract: An exhaust aftertreatment combined filter and catalytic converter has a plurality of flow channels each having both: a) a flow-through channel catalytically reacting with the exhaust; and b) a wall-flow channel trapping particulate such as soot. A filter is also provided.

Abstract: The present invention relates to a plasma reactor for reducing noxious gas by using a plasma reaction, a production method for such a plasma reactor, and an emission control apparatus for reducing noxious gas contained in exhaust gas of a vehicle by use of such a plasma reactor.

Abstract: A heater is disposed in contact with a hydrogen storage unit filled with a hydrogen absorption material. The heater includes at least one combustion chamber which includes a catalyst carrier and in which a combustible gas is burned, a combustible gas burning catalyst carried on the catalyst carrier, at least one combustible gas introduction chamber adjoining the combustion chamber with its chamber wall interposed therebetween, a plurality of combustible gas inlets disposed in a dispersed manner in the chamber wall to permit the combustion chamber and the introduction chamber to communicate with each other, and a combustion gas outlet communicating with the combustion chamber. Thus, the degree of uniformity of a temperature profile is decreased.

Abstract: Continuous biowaste sterilization process, the operability of which is ensured in such a way that during process startup, extreme conditions possibly coming into question during operation are simulated, i.e. the greatest possible flow rate and the lowest temperature of the feed flow. In the startup stage, a liquid to be sterlized is circulated in the apparatus, until the capacity has been ascertained, whereafter the discharge stream can be conducted to a sewer system. The apparatus according to the invention comprises, in the flow direction of the biowaste-containing liquid, a storage tank, at least one feed pump capable of delivering a constant flow, at least one heating unit, at least one cooling unit, and a circulation circuit for circulating the biowaste-containing liquid through the heating unit, as well as connecting piping and valves. By means of specific piping and valve arrangements it is also ensured that all parts of the apparatus can be sterilized for maintenance purposes.

Abstract: The present invention discloses a process for producing nanometer powders, comprising the following steps: (a) providing reactant solution A and reactant solution B that can rapidly react to form precipitate; (b) continuously adding said solution A and solution B into a mixing and reacting precipitator with a stator and a rotor in operation, respectively; and (c) post-treating the precipitate-containing slurry discharged continuously from the mixing and reacting precipitator. The present process could produce nanometer powders with adjustable particle size, good homogeneity in size and good dispersity. The method also has the characteristics of high production yield, simplicity in process and low consumption of energy. It could be applied to produce various nanometer powders of metals, oxides, hydroxides, salts, phosphides and sulfides as well as organic compounds.

Abstract: A bismuth-213 generator comprising an insoluble composition having the general formula Zr(Phosponate)x(HPO4)2?x.nH2O, wherein x is between 0 and 2; and n is the number of waters of hydration; and wherein cations of radioactive isotopes selected from radium, actinium and combinations thereof are immobilized on the composition. The value of x may be between about 0.2 and about 1. The phosphonate may be n-phosphonomethyl-miniodiacetic acid (PMIDA), wherein x may be between about 0.1 and about 1.9. The phosphonate may be one or more phosphonate having the formula: H2O3P—(CH2)a—N—((CH2)bCO2H)—((CH2)cCO2H), wherein a, b, and c are numbers from 1 to 3 that may or may not be equal. The value of x may also be between about 0.1 and 1.9.

Abstract: A method for catalytically cleaning an exhaust gas, including receiving the exhaust gas in an inlet channel, blocking the exhaust gas in the inlet channel, diffusing the exhaust gas through a porous substantially fibrous nonwoven wall of the inlet channel, reacting the exhaust gas with at least one catalyst material to at least partially remove nitrous oxides, hydrocarbons and carbon monoxide therefrom, the at least one catalyst material being disposed on the porous wall, trapping particulate matter in the porous substantially fibrous nonwoven wall, receiving the diffused exhaust gas into an outlet channel, and transitioning the exhaust gas from the outlet channel to the atmosphere.

Abstract: A method of preparing spherical pellets from a slurry comprising a ceramic powder, a solvent, and any desired additives, by means of a drop-generating orifice to which said slurry is fed is described, wherein the drops are released from said orifice by means of a relative flow of a liquid medium which is a poor solvent for the solvent of the slurry, formed into spherical bodies in said liquid medium by means of the action of surface tension, and thereafter treated for consolidation. More specifically, the present invention relates to the preparation of pellets of a catalyst or catalyst support material, suitable for use in high temperature conditions.

Abstract: The present invention is directed to lanthanide vanadate crystals having the formula LnVO4, wherein Ln is selected from La, Nd, Ce, Pr, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y, and combinations of at least two thereof, made by a hydrothermal method for a wide variety of end-use applications. The present method requires reacting a source of Ln3+ ions and a source of VO43+ ions, wherein Ln is selected from the group consisting of La, Nd, Ce, Pr, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y and combinations of at least two thereof, in an aqueous solution at a temperature of from about 350° C. to about 600° C. and at a pressure of from about 8 kpsi to about 40 kpsi, the aqueous solution comprising hydroxide ions at a concentration of from about 0.01 to about 5 molarity. Specifically, when made by the present hydrothermal method, single crystals of sufficient size for use in a variety of optical applications are readily formed.

Abstract: A method is described for the manufacture of hydrotalcites by using at least one compound of a bivalent metal (Component A) and at least one compound of a trivalent metal (Component B), wherein at least one of these components is not used in the form of a solution, characterized in that a) at least one of the Components A and/or B which is not used in the form of a solution, shortly before or during mixing of the components, and/or b) the mixture containing the Components A and B is subjected to intensive grinding until an average particle size (D50) in the range of approx. 0.1 to 5 ?m is obtained, and optionally, after aging treatment or hydrothermal treatment, the resulting hydrotalcite product is separated, dried, and optionally calcinated.

Abstract: Described is a method for the production of metal oxides by flame spray pyrolysis, in particular mixed metal oxides such as ceria/zirconia, and metal oxides obtainable by said method. Due to high enthalpy solvents with a high carboxylic acid content said metal oxides have improved properties. For example ceria/zirconia has excellent oxygen storage capacity at high zirconium levels up to more than 80% of whole metal content.

Abstract: Single-phase lithium-transition metal oxide compounds containing cobalt, manganese and nickel can be prepared by wet milling cobalt-, manganese-, nickel- and lithium-containing oxides or oxide precursors to form a finely-divided slurry containing well-distributed cobalt, manganese, nickel and lithium, and heating the slurry to provide a lithium-transition metal oxide compound containing cobalt, manganese and nickel and having a substantially single-phase O3 crystal structure. Wet milling provides significantly shorter milling times than dry milling and appears to promote formation of single-phase lithium-transition metal oxide compounds. The time savings in the wet milling step more than offsets the time that may be required to dry the slurry during the heating step.

Abstract: Mesoporous aluminum oxides with high surface areas have been synthesized using inexpensive, small organic templating agents instead of surfactants. Optionally, some of the aluminum can be framework-substituted by one or more other elements. The material has high thermal stability and possesses a three-dimensionally randomly connected mesopore network with continuously tunable pore sizes. This material can be used as catalysts for dehydration, hydrotreating, hydrogenation, catalytic reforming, steam reforming, amination, Fischer-Tropsch synthesis and Diels-Alder synthesis, etc.

Abstract: A process for preparing a zeolitic material, comprising (i) preparing a mixture comprising the at least one silicon containing precursor compound from which the zeolitic framework is formed, at least one pore forming agent, and at least one polymer which has an essentially spheroidal geometry in the mixture; (ii) crystallizing the zeolitic material from the mixture obtained in (i) to obtain the crystallized zeolitic material in its mother liquor.

Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.

Abstract: Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging.

Abstract: The present invention relates to a hair care composition comprising a terminal aminofunctional polysiloxane, which provides improved durable conditioning particularly when utilised in conjunction with a hair colouring composition.

Abstract: A composition for coating a keratinous fiber comprising, in a cosmetically acceptable medium, at least one volatile solvent and a nonvolatile fraction comprising: at least one polymer capable of adhering to a keratinous material; particles which are solid at 25° C. comprising at least one first material chosen from crystalline and semicrystalline materials which are solid at 25° C. and have at least one of a first order phase transition, a melting transition and a combustion transition, greater than 100° C.; wherein the first solid particles are present in the composition in an amount such that the volume fraction of the solid particles is greater than or equal to 50% of the total volume of the nonvolatile fraction of the composition. The composition makes it possible to obtain good curling of keratinous fibers, such as eyelashes.

Abstract: The invention relates to a novel cosmetic product with special flexibility and stretching characteristics, so-called “stretch-mascara”. The mascara has an oil phase and an aqueous phase, said oil phase containing 2 to 10 wt. % of an unbranched polyethylene wax with a molecular weight of 400 to 1500 Dalton, in relation to the weight of the oil phase, and at least one other wax or oil or mixture thereof. The aqueous phase contains 0.5 to 5% of a film former PVP/PVP-VA, polyquaternium-46 and mixtures thereof. The product also contains 0.5 to 20 wt. % of an external film former phase with a water-soluble film former selected from the group PEG/PPG-25/25 dimethicone/carylates/t-butyl acrylates copolymer, polyurethane-1 and mixtures thereof.

Abstract: The present invention provides a composition comprising (i) a compound comprising a sulphamate group (“a sulphamate compound”); and (ii) an apoptosis inducer.

Abstract: The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical side. Transduction efficiency in AEC increased with increasing MOI and greatly exceeded that achieved with a similarly pseudotyped MLV retrovirus vector. The present invention also demonstrates the successful in vivo transfer of genes through lentivirus vector transduction. Mammals injected with lentivirus vector via the trachea expressed the reporter protein in alveolar epithelial cells within 48 to 72 hours after infection.

Abstract: A method for transfection of DNA or RNA encoding apo A1 into the liver to regulate lipid metabolism comprises injection of a solution containing the DNA or RNA gene into the liver in combination with gas microbubbles or microspheres and using ultrasound to induce the transfection of the DNA or RNA in the liver.

Abstract: The present invention provides a method of sustaining the rate of heat felt on the skin as a result of an exothermic reaction between a combination of an unencapsulated and an encapsulated catalase, and peroxide. The catalase component provides a sustained heat release and in combination with other non-catalase heat-generating agents, the rate of heat released and felt on the skin can be further controlled. The compositions of the present invention also soften the skin and contribute to the health of the skin by reducing the presence of oxygen free radicals on the skin surface.

Abstract: A pharmaceutical composition and method for use in inhibiting growth of cancer cells in a mammalian subject are disclosed. The composition includes a urease enzyme, and associated therewith, a chemical entity effective to enhance the delivery of the enzyme to cancer cells, when the composition is administered to the subject. Also disclosed are a method of enhancing the effectiveness of weakly basic anti-tumor compounds, a method assessing the presence, size or condition a solid tumor in a subject, and a gene therapy composition for treating a cancer in a subject.

Abstract: The present invention provides isolated nucleic acids encoding TfR2 polypeptides, or fragments thereof, and isolated TfR2 polypeptides encoded thereby. Further provided are vectors containing the nucleic acids of the present invention, host cells transformed therewith, antisense oligonucleotides thereto and compositions containing antibodies that specifically bind to invention polypeptides. Methods of detecting TfR2 protein in a cell are also provided.

Abstract: Antagonists of alpha 4 integrin/alpha 4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of multiple myeloma cells to bone marrow and their alpha 4 integrin-dependent release of bone-resorbing factors, resulting in bone destruction in patients with multiple myeloma, is inhibited.

Abstract: The invention relates to novel modified erythropoietin (EPO) forms such as fusion proteins comprising a Fc portion of an Ig molecule and a target molecule having the biological activity of EPO. By selective altering of the amino acid sequences of the erythropoietin moiety as well as of the immunoglobulin moiety and the glycosylation pattern of erythropoietin fusion proteins with enhanced biological activity can be obtained. The invention relates also to novel nun-fused EPO molecules which have a pattern of cysteines or disulfide bonding which is distinct from human or animal EPO.

Abstract: A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein.

Abstract: Oral, topical and injectable contraceptives, which are based on sperm protein 22 kDa (SP22) polypeptides and antibodies and infertility diagnostics are provided.

Abstract: The present invention relates, in part, to a purified polyclonal or monoclonal antibody which recognizes an epitope of a protein of 48,000 dalton, where the protein recognizes is a surface protein of a merozoite of Plasmodium falciparum which has a peptide of SEQ ID NO:1 or a sequence wherein SEQ ID NO:1 has been modified by insertion, deletion or substitution and the sequence inhibits the binding of monoclonal antibody 245 to Plasmodium merozoites, as well as fragments of the antibody; the present invention relates to composition and kits containing the same, as well as methods of using the same.

Abstract: The present invention is directed to compositions and methods to modulate inflammatory and immune responses in a subject, which includes immune activation and inhibiting inflammatory responses, by modulating the regeneration and tolerance factor (RTF).

Abstract: The invention provides methods for modulating an immune response in a subject including, for example, administering to the subject a composition comprising an effective amount of a lymphocyte differentiation factor sufficient to modulate the immune response. In one aspect, the lymphocyte differentiation factor comprises protein A (PA).

Abstract: Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.

Abstract: The present invention is concerned with isolated infectious bursitis (or bursal) disease virus(es) and a vaccine containing said virus(es) which is capable of protecting poultry against disease caused by infectious bursitis virus, characterized in that the vaccine virus(es) has/have the combined properties of, upon administration to a chicken, causing a reduction in the bursal size, expressed as bursa/body weight ratio, of less than 55%, and the capability to protect poultry having an ELISA antibody titer of at least about 500.

Abstract: The invention includes liquid formulations of botulinum toxin that are stable to storage in liquid form at standard refrigerator temperatures for at least 1–2 years and to storage at higher temperatures for at least 6 months. The invention also includes methods of treatment using such formulations for various therapeutic and cosmetic purposes.

Abstract: Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.

Abstract: The invention relates to a method of immunizing a mammal against infection by a first Bordetella species. The method comprises administering to the mammal a preparation comprising a portion of the amino acid sequence of mature adenylate cyclase of a second Bordetella species. The invention also relates to vaccine preparations comprising a portion of the amino acid sequence of mature adenylate cyclase from Bordetella species.

Abstract: The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.

Abstract: Vaccines for the prevention and/or treatment of Eimeria infection including one or more strains of E. maxima ARI-73/97, E. acervulina ARI-77/97, E. tenella ARI-11/98, E. necatrix MCK01 and/or E. necatrix ARI-MEDNEC3+8 are described. Eimeria selected from E. maxima ARI-73/97, E. acervuina ARI-77/97, E. tenella ARI-11/98, E. necatrix MCK01 and/or E. mecatrix ARI-MEDNEC3+8 are also described.

Abstract: A composition includes calcium sulfate hemihydrate, stearic acid, an accelerant, and a mixing solution. The composition can be injected, e.g., through a needle, and is capable of setting, e.g., in vivo, in a relatively short period of time to a relatively high hardness.

Abstract: A method of treating acne in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat acne but has substantially no antibiotic activity, without administering a bisphosphonate compound.

Abstract: A process for preparing compounds from the polysaccharide betainate family, novel compounds so obtained, and their use in cosmetics or in dermatology, as well as the compositions, such as cosmetic or dermatological compositions, comprising said novel compounds.

Abstract: Method for preparing a cosmetic or dermatological composition, of a sufficient amount of peptides of sequence (Gly-Pro-Gln)n-NH2, wherein: n ranges between 1 and 3, and the amino acids can be in the form L, D or DL; the peptides or the composition being designed to: promote adhesion between skin cells, promote cell adhesion, to provide curative and/or preventive treatment for ageing skin symptoms (of physiological or solar origin) and to enhance skin appearance. In a preferred embodiment, the peptide is of sequence (Gly-Pro-Gln)2-NH2.

Abstract: This invention provides compounds of Formula I, N-oxides and suitable salts thereof wherein A is O or S(O)?m#191;J is a phenyl or heterocyclic ring as defined herein; and R1 through R12, n, m and r are as defined in the disclosure. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula I, an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula I, an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of a surfactant, a solid diluent and a liquid diluent.

Abstract: Hydroxyapatite is treated by a combination of nitridation and the application of bone morphogenetic protein or DNA encoding such a protein to improve the tissue compatibility and affinity of the hydroxyapatite, rendering the hydroxyapatite more useful as a material for biomedical implants.

Abstract: A drug delivery device for placement in the eye includes a drug core comprising a pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material impermeable to passage of the active agent and includes an opening for passage of the pharmaceutically agent therethrough to eye tissue. The device includes a layer of material permeable to passage of the active agent. In assembling the device, a pin or weight, having a shape similar to the drug core, is used during curing of the permeable material.

Abstract: Detergent or personal care compositions comprising capsules, which in turn comprise a hydrophobic continuous phase, the latter comprising an isotropic mixture of a thermoplastic-type co-polymer and hydrocarbon oil. Preferably, the capsules further comprise an oil-soluble benefit agent. Preferably, the compositions are liquid, especially aqueous-based compositions. In the preferred embodiment, the capsules are transparent or translucent.