Abstract: The invention relates to a dosage form, containing the active ingredient cholylsarcosine, in the form of pellets, which are provided with a polymer coating that is resistant to gastric juices. The invention is characterised in that it discloses pellets comprising an active ingredient, which contain between 50 and 80 wt. % of the active ingredient cholylsarcosine and between 50 and 20 wt. % of one or more conventional pharmaceutical adjuvants as binding agents, whereby at least 90 wt. % of said adjuvants are water-soluble and the size of at least 80 % of the pellets comprising an active ingredient is between 800 and 2,500 $g(m)m. The granulates containing an active ingredient are coated with an anonic, film-forming polymer coating agent, which dissolves in a 0.07M sodium phosphate buffer with a pH value of 5.5 at a dissolution rate of at least 10 mg/min*g and whose dissolution rate in a 0.07M sodium phosphate buffer with a pH value of 6.0 is at least 200 mg/min*g.

Abstract: Solid dose rapidly disintegrating compositions for administering pharmaceutical and nutritional supplement agents and methods for the preparation thereof are disclosed and described. Preparation methods which maintain the particulate size of an active agent at the pre-processing size in the final composition are further disclosed. The ability to maintain such particulate size provides a number of advantages, including improved bioavailability and more accurate dosing.

Abstract: A pyridoxal-5?-phosphate pharmaceutical formulation suitable for oral administration is provided comprising a dissolution profile, when measured in a standard dissolution apparatus, according to the United States Pharmacopoeia dissolution test, at 37° C. in a 0.05M phosphate buffered solution having a pH of 6.8 at 75 rpm, as follows: (a) greater than about 30% at 15 minutes, (b) greater than about 85% at 30 minutes, (c), greater than about 90% at 45 minutes, or (d) greater than about 95% at 60 minutes. Additionally, in vivo oral intake of between 15 and 60 mg/kg of a pyridoxal-5?-phosphate pharmaceutical formulation can produce a maximum plasma level (Cmax) of between about 1 mg/L and 8 mg/L. A pharmaceutical formulation provided comprises (a) a core, wherein said core comprises pyridoxal-5?-phosphate or a pharmaceutically acceptable salt thereof; (b) a sub-coat surrounding the core; and (c) an enteric coat surrounding the sub-coat.

Abstract: A method of optimizing a dissolution profile for a selected active agent dosage form, comprises combining a first amount of a first ensemble of pulsed-release pellets having a first dissolution profile with a first T50 and a second amount of a second ensemble of pulsed-release pellets having a second dissolution profile with a second T50 to produce a combination ensemble of pellets having a combination dissolution profile of a combination slope, wherein the combination slope corresponds to a single phase release, and wherein the combination slope is greater than 10% lower than the slope of the first dissolution profile and greater than 10% lower than the slope of the second dissolution profile, and wherein the first ensemble of pellets and the second ensemble of pellets comprise a core having disposed thereon a core composition layer, the core composition layer comprising the active agent, and a pulsed-release coating disposed on the core composition layer.

Abstract: Provided herein, are dosage forms comprising an NSAID, a buffer and a PPI, as well as methods of treating various maladies using the above dosage form.

Abstract: Disclosed herein are methods and compositions suitable for providing zero-order release of active agents. Disclosed herein is a multiparticulate oral dosage form comprising a plurality of pulsed-release pellets, wherein the dosage form releases the active agent at a substantially constant rate following a lag time. The dosage form comprises a combination ensemble of pellets produced by combining 2 to 8 individual ensembles of pulsed-release pellets having a particular T50 and dissolution profile.

Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon

Abstract: The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.

Abstract: The present invention pertains to the design and application of a supramolecular hydrogel having a three-dimensional, self-assembling, elastic, network structure comprising non-polymeric, functional molecules and a liquid medium, whereby the functional molecules are noncovalently crosslinked. The functional molecules may be, for instance, anti-inflammatory molecules, antibiotics, metal chelators, anticancer agents, small peptides, surface-modified nanoparticles, or a combination thereof. The design of the hydrogel includes: 1) modifying functional molecules to convert them into hydrogelators while enhancing or maintaining their therapeutic properties and 2) triggering the hydrogelation process by physical, chemical, or enzymatic processes, thereby resulting in the creation of a supramolecular hydrogel via formation of non-covalent crosslinks by the functional molecules.

Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.

Abstract: The present invention relates to a solid pharmaceutical composition comprising a solid dispersion containing at least one active principle and a pharmaceutically acceptable polymer matrix, a characterized in that said pharmaceutically acceptable polymer matrix comprises a blend of (i) polydextrose, in the form of a continuous polydextrose phase, in order to promote the disintegration of the composition in an aqueous medium, and (ii) at least one polymer other than polydextrose, in the form of a continuous phase of this polymer, whereby the polydextrose is in a concentration of at least 20 wt % and the at least one polymer other than polydextrose is in a concentration of at least 20 wt % in relation to the total weight of said pharmaceutically acceptable polymer matrix.

Abstract: An apparatus and method of making crosslinked chromonic nanoparticles includes providing a first aqueous liquid stream including a continuous water-soluble polymer phase and a discontinuous chromonic material phase, providing a second aqueous liquid stream including a salt solution having a multivalent cation, and contacting the first aqueous liquid stream with the second aqueous liquid stream in parallel laminar flow to non-covalently crosslink the chromonic material with the multivalent cation, forming crosslinked chromonic nanoparticles. The chromonic material phase can optionally include an encapsulated guest molecule.

Abstract: The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins or peptides to an animal subject. The nanoparticles are composed of positively charged shell substrate, negatively charged core substrate with encapsulated bioactive agents of proteins or peptides.

Abstract: Glycopyrrolate or an analogue thereof is useful for the treatment of childhood asthma.

Abstract: One of the most prominent amino acids found in biological proteins is aspartic acid. In the present invention L-aspartic acid was heated at 150 deg C for up to 100 hrs to form thermal polyaspartylimide which when heated in boiling water without addition of base hydrolyzed to form thermal polyaspartic acid which upon cooling formed protective biocompatible microcapsules.

Abstract: The invention provides stable S-nitrosothiol, such as S-nitrosoglutathione, formulations for long term storage and in vivo delivery of S-nitrosothiols. The invention provides stable aerosol formulations comprising S-nitrosothiol, such as S-nitrosoglutathione, and methods of treating patients in need of S-nitrosothiol, such as S-nitrosoglutathione, and/or nitric oxide treatment.

Abstract: Combinations of silver and copper ion sources or a single source of both silver and copper ions are found effective in methods for treating viral infections and for treating surfaces so as to eradicate viral contaminants and/or prevent subsequent contamination of said surfaces with viruses. These methods are particularly applicable in addressing SARS and avian flu viruses.

Abstract: This invention relates to methods of thickening dilute hypochlorite and hypochlorous acid compositions. These compositions are thickened with inorganic thickeners, especially synthetic clays. The compositions can additionally contain buffering agents. The compositions show good performance on mold.

Abstract: A system and method for extracting active elemental iodine from the contact of water with stored crystal iodine and for introducing the extracted elemental iodine into a water supply line and/or otherwise making the extracted elemental iodine available for an intended use. The system operates by allowing a portion of the water entering from a water supply line to be redirected to a first housing where it makes contact with stored crystal iodine causing to extract active elemental iodine. The iodinized water leaves the first housing and enters a second housing where it makes contact additional stored crystal iodine to help stabilize the elemental iodine concentration. The system can be designed to provide the elemental iodine in more than one potency concentration through the use of a metering valve and different travel routes for the elemental iodine out of the second housing.

Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Abstract: Methods of preparing and using natural or synthetic zeolitic compositions therapeutically to alleviate, cure, or even preclude human host indisposition from exposure to bacteria within the Bacillus anthracis group: namely, B. anthracis, B. cereus, B. Mycoides, and B. thurigiensis. Exposure to bacilli of the first member of that group causes the often fatal disease anthrax.

Abstract: The invention relates to compositions comprising one or more prebiotics (e.g., one or more dietary fibers) in combination with selenium compounds, flavonoids and/or flavonols, and phosphatides. The invention also relates to methods of regulating disorders, specifically disorders of the intestinal tract and related disorders, by administering a composition of the invention.

Abstract: The invention is related to methods and compositions for improving feeding and/or production characteristics in animals. In an embodiment, the invention includes a method for improving feeding characteristics of an animal including administering a first composition comprising an effective amount of saponins to the animal, and administering a second composition comprising an effective amount of a preservative to the animal. In an embodiment, the invention includes a method for improving production characteristics of an animal including administering a first composition comprising an effective amount of saponins to the animal, and administering a second composition comprising an effective amount of a preservative to the animal.

Abstract: Methods of reducing cellular damage are described that include (a) administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant, and (b) administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant, wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate. Methods of inhibiting free radical production, methods of scavenging free radicals, and kits for reducing cellular damage are also described.

Abstract: A composition is provided to treat and/or prevent for treating skin conditions including fine lines and wrinkles, acne rosacea, surface irregularities of the skin and hyper-pigmentation melasma of the skin, which includes use of a topically applied composition such as an ointment, lotion, cream, serum, gel or pad applied formulation, containing an effective amount of polyphenols, such as green tea based polyphenols, including but not limited to catechins, such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicathechin 3-gallate (ECG) and epicatechin (EC). The formulation is preferably composed of 90 percent polyphenol isolates, derived from green tea with potent antioxidant properties, to assist in minimizing free-radical induced skin damage.

Abstract: A nutritional fiber derived from stabilized rice bran is described, which is beneficial for treating colon cancer in an individual. Methods for decreasing the likelihood of colon cancer are also described.

Abstract: The invention features a method for inhibiting or reducing the deleterious effects of tobacco smoking including increased incidence of cancers, cardiovascular diseases, various lung disorders and the oxidative effects. The method includes the incorporation of an effective amount of a compound or a standardized plant extract that is that comprises an inhibitor of NF-?B into tobacco or a tobacco product. In particular, it relates to useful NF-?B inhibitor diterpenes and compositions containing them for incorporation into tobacco or a tobacco product.

Abstract: Compositions and methods of making compositions containing nopal cactus isolates derived from the juice and/or soluble solid fractions of nopal pads. In another aspect, the invention relates to compositions for making coffee, coffee compositions and methods of making such compositions, which contain nopal cactus isolates.

Abstract: The instant invention provides methods and compositions for the treatment of infection or infectious colonization of the eyelid and/or ocular surface for the treatment and prevention of ocular disorders and eyelid disorders.

Abstract: The invention refers to a laboratorial extrusion line, illustrated in FIG. 1, that has the ability to be used both for the production of conventional and bi-oriented tubular film (monolayer or multilayer), with simple commutation between the two techniques. The line encompasses two movable extruders (1 and 2), one extrusion die for the production of conventional film (3), one extrusion die for the production of bi-oriented film (4), one unit for the internal calibration/cooling of the primary (5), one water ring for the external cooling of the primary (6), four sets of pulling rolls (7 to 10), three air rings to cool down the film (11 to 13), two units for the thermal conditioning of the primary (14 and 15) and one winding unit (16). The use of some of the components (1, 3, 11, 8, 10 and 16) enables the production of conventional tubular film, while another set of components (1, 2, 4, 5, 6, 7, 9, 14, 15, 12, 13, 10 and 16) is used for the production of bi-oriented tubular film.

Abstract: An exemplary molding assembly includes: a first mold housing defining a first engaging hole; a second mold housing configured for attachment to the first mold housing; a containing block received in the first mold housing and defining a second engaging hole; a first core member received in the first containing block and having a molding surface thereon; a second core member received in the second mold housing for matching with the first core member; a first elongated adjusting member having a first portion locked by rotational engagement in the first engaging hole and a second portion in threaded engagement with the containing block; a second elongated adjusting member having a first portion locked by rotational engagement in the second engaging hole and a second portion in threaded engagement with the first core member. Lengthwise directions of the first and the second elongated adjusting members are oriented perpendicular to each other.

Abstract: A logo embossing assembly for sheet products comprising at least one supporting frame for at least one embossing roller and at least one presser roller, which are arranged so as to have parallel axes substantially in mutual contact along respective generatrices and between which at least one continuous ribbon from which the sheet products are obtained can pass, the embossing roller and the presser roller being provided with respective motion transmission elements which are associated with a power-assisted rotary actuation, that is functionally controlled by at least one programmable control and processing unit adapted to perform the angular phase adjustments of the embossing roller with respect to fixed references of the continuous ribbon, so as to provide figures in relief on the products in predefined regions in relation to specific production requirements.

Abstract: The present invention is directed to a template that features a control surface extending from a periphery of a mold toward a recessed surface of the template forming an oblique angle between a portion of the control surface disposed proximate to the periphery.

Abstract: A concentric machining device for a roller includes a movable upper base, a stationary lower base, two movable mold seats, two slide rods and four first hydraulic cylinders. Each of the mold seats has a forming mold inside, the forming mold has a fitting hole with an enlarged conical opening at the front side thereof, a locating shaft is received in the forming mold of the first mold seat and penetrates the fitting hole thereof and the first cylinder member, a clamping shaft is received in the forming mold of the second mold seat and penetrates the fitting hole thereof and the second hydraulic cylinder to connect with the fourth hydraulic cylinder. The roller is held by the bases and the shafts via two of the hydraulic cylinders and both ends of the roller are machined by the forming molds in the mold seats to provide squeezed and shrunk shapes once the mold seats are actuated by the other two hydraulic cylinders.

Abstract: A method of transcribing a shape of a surface of a stamper on a transcription surface of a transcription object by pressing the stamper on the transcription object, which comprises steps of: having one of the stamper and the transcription object positioned opposite a plate surface and the other of the stamper and the transcription object placed on one surface of a pressure plate; and having the one of the stamper and the transcription object pressed onto the plate surface by applying a fluid on the other surface of the pressure plate, wherein an area of the one surface of the pressure plate is larger than a contact area in which the other of the stamper and the transcription object is in contact with the pressure plate.

Abstract: It is intended to further improve the dimensional accuracy of a catheter molded by a catheter molding apparatus 1. The catheter molding apparatus (1) includes a fore-stage extrusion molding device (12) for extrusion molding an inner layer tube (4) of resin so as to fit a core wire material (3) of metal therein, a braided layer attaching unit (14) for attaching a braided layer (5) made by the braiding of a reinforcing thread (6) to the outer surface of the inner layer tube (4) molded by the fore-stage extrusion molding device (12) and once cooled, thereby molding a braided tube (7), a post-stage extrusion molding device (19) for extrusion molding a raw material tube (2) for a catheter by fitting an outer layer tube (8) of resin thereon, and a take-off unit (21) for taking off the raw material tube (2).

Abstract: An extrusion-molding machine according to the present invention comprises: a screw having a blade portion for extruding a molding material, the screw disposed in a tightly-closed space; and a die for molding an extruded molding material, wherein the space is maintained in a reduced-pressure atmosphere, and a high-hardness coat layer is formed at least on the blade portion.

Abstract: A device for expansion injection moulding, by which a polymer melt placed under pressure by a main pressure source can be injected from a storage chamber (4) into a mould cavity (3) by expansion of the polymer melt stored under pressure, the injection is optionally assisted by elastic deformation of the wall (8) of the storage chamber (4) and/or the wall (7) of a runner 6 leading to the storage chamber (4), the storage chamber (4) having an exit (5) which can be shut off, wherein the storage chamber (4) is arranged in a mould (1) which forms the mould cavity (3) and an additional pressure accumulator and/or an additional pressure source is (are) provided which is (are) capable of exerting additional pressure on the polymer melt during injection of the polymer melt into the mould cavity (3), in order to fill—preferably completely—the mould cavity (3).

Abstract: The present invention provides a composite nozzle cap having a first part made of metal and an outer tip of a polymeric material. The first part mechanically secures the nozzle into the nozzle housing by engaging the nozzle housing and pressing against a base flange on the nozzle to clamp the flange between the first part of the nozzle housing. The second part extends away from the nozzle housing and is mechanically secured to the first part. An inner face of the second part contacts the nozzle tip to prevent melt flow between the second part of the nozzle tip. An outer face of the second part contacts the gate insert to avoid melt flow between the second part and the gate insert. As the second part is of a polymeric material, it avoids the heat transfer concerns associated with a metallic interface between the nozzle tip and the gate insert.

Abstract: An angular ejector mechanism for ejecting a plastic article with a recess in an inner side includes an angular ejector pin, a sliding pin, an elastic elements and a stopping block. The angular ejector pin includes a molding plate and a supporting plate. A moving hole and a sliding groove are respectively defined in a front face and an opposite rear face of the molding plate to communicate with each other. The sliding pin has a stopping protrusion dividing the sliding pin into a moving portion and a sliding portion. A sliding channel is defined on a front face of the stopping block. The sliding includes a vertical channel and a inclined channel. The moving portion is received in the moving hole of the molding plate, and the sliding portion slides from the sliding channel into the inclined channel until the angular ejector pin separates from the plastic article.

Abstract: The present invention encompasses, in part, a method and apparatus for lens casting in which two molds, preferably formed of plastic, are interconnected or joined together via a ring to form a mold cavity having substantially the same dimensions of the lens to be formed therein. The invention is further directed to compositions and methods used in lens casting. In a first implementation the invention includes a mold having a ring having an interior periphery; a front mold formed of a plastic and having a lens-forming surface, an edge circumscribing the lens-forming surface that is sized to be complementarily received within a portion of the interior periphery of the ring, and a base having dimensions greater than the interior periphery; and a rear mold formed of a plastic and having a lens-forming surface.

Abstract: Meat and methods to produce meat having elevated levels of HDL or an HDL mimetic are disclosed.

Abstract: The present invention relates to a method of preparing a stable liquid leaven composition which contains a bread flavor improvement composition (for instance sourdough or sponge based composition), an active yeast and a bread improver composition. Stable liquid compositions according to the invention are obtained when the residual sugar content is kept low, preferably below 0.5% w/w on the liquid composition and/or when severe drops in pH are prevented. The present invention further relates to liquid leaven compositions obtained as such and to their use in for instance bakery products like bread, snacks and pizzas.

Abstract: Disclosed is a method of tailoring infant formulas to individual nutrition needs prior to use. The method comprises (A) determining the desired volume and optimal caloric density of a formula to be fed to a preterm or low birth weight infant; (B) obtaining a plurality of base infant formulas, all in liquid form, comprising fat, protein, carbohydrate, vitamins, and minerals, each of which has an osmolality of from about 200 to about 360 mOsm/kg water and a different caloric density within a range of from about 609 to about 1082 kcal/L; (C) selecting two of the base liquid formulas having a caloric density value above and below the optimal caloric density, (D) calculating the volume of each selected base formula needed to produce the desired volume of an infant formula blend having the optimal caloric density; (E) combining the calculated volumes to produce a an isotonic blend having the desired feeding volume and optimal caloric density. The formula is then fed to the preterm or low birth weight infant.

Abstract: A pizza includes a dough member and at least one topping disposed on the dough member. The dough member defines a substantially flattened shape and includes a central portion and a border portion. The central portion defines a perimeter. The border portion extends about the perimeter of the central portion. The border portion of the dough member is divided into a plurality of dough segments, each dough segment being turned relative to the perimeter of the central portion.

Abstract: Making a pizza crust includes forming a mass of dough into a substantially flattened shape to define an inner crust bordered by an outer crust extending around the inner crust. The outer crust is divided into a plurality of segments without cutting the inner crust by pressing a plurality of cutting fins of a cutting ring through the outer crust to form the plurality of segments. Each of the plurality of segments defines a first end, a second end opposite the first end, a first side facing the inner crust, and a second side facing opposite the inner crust. Each of the plurality of segments is turned such that the second end is moved away from the inner crust.

Abstract: The invention relates to a flexible packaging. Specifically, this invention relates to a laminate, the use of the laminate in the packaging of food, drinks, medicine and toys, and a corresponding package. The laminate can be a film-to-film and film-to-foil laminates, suitable for typical food packaging uses, using hot melt laminating adhesives. Such laminates are substantially fee from volatile contaminates, especially migratable isocyanates and aromatic amines.

Abstract: The invention provides a method for the preparation of a foamed drink comprising the steps of: providing a capsule containing a foamable ingredient; providing a receptacle positioned to collect fluid escaping from the capsule; injecting liquid into the capsule to mix with the foamable ingredient; allowing the foamable ingredient mixed with the liquid to escape from the capsule into the receptacle; followed by injecting further liquid into the receptacle in a jet having a diameter of from about 0.5 to about 2 mm to produce foamed liquid in the receptacle. The invention also provides capsules, apparatus and systems specifically adapted for use in the method. Preferably, the food ingredient is a milk powder, and the method produces a hot foamed beverage such as a cappuccino coffee.

Abstract: The present invention relates to processes for inactivating microbial spores in packaged materials including foods pharmaceuticals and cosmetics, by a combination of ultra high pressure processing and oxygen absorption.

Abstract: A therapeutic supplement utilizes a processed form of the Ume fruit in the absence of the Ume seed. In a preferred form, the Ume fruit is processed to achieve a higher alkalinity to increase its therapeutic effectiveness.