Abstract: The present invention relates to an antitumor immune response, and in more detail, to a method for inducing cytotoxic T lymphocytes specific to a tumor-associated antigen that acts specifically on tumor cells. Immunotherapy using the present invention may be most effective among immune therapies that use immunity of our body, because in the present invention, CEA-specific cytotoxic T lymphocytes can be induced in vitro by using a dendritic cell transduced with a recombinant adenovirus. Further, immunotherapy using the present invention can function as a powerful tool for tumor prevention or treatment, if being used in combination with antitumor vaccines or other treatments.

Abstract: A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide fused to a protein sequence that mediates the induction of RPBLA formation is expressed and accumulated in host cells after transformation with an appropriate vector. The eukaryotic host cell does not produce protein bodies in the absence of the fusion protein. Methods for preparing and using the RPBLAs and the fusion protein are also disclosed, as are nucleic acid molecules that encode the fusion proteins.

Abstract: The present invention provides methods of inducing an immune response against Clostridium species in birds, for protecting birds from Clostridium infection, and/or for protecting birds from related disorders such as necrotic enteritis. The methods can be practiced in ovo and/or post-hatch. The invention further provides compositions and methods for delivery of a composition of this invention in ovo directly to the embryo body.

Abstract: The present invention relates to methods for using prokaryotic cells which have been modified or induced to synthesize trehalose as vaccines and to vaccine compositions obtained thereby.

Abstract: The invention relates to a method for the selection of epitopes for immunotherapy, peptides obtained by said method, the use of said peptides as vaccines and diagnostics and an immune serum obtainable by said method.

Abstract: The invention concerns new tumor necrosis factor receptor associated factors, designated TRAF. The new factors are capable of specific association with the intracellular domain of the type 2 TNF receptor (TNF-R2), and are involved in the mediation of TNF biological activities.

Abstract: This invention relates to novel HIV polypeptide and polynucleotide fusions of Gag; Pol and Nef which are useful in immunogenic compositions and vaccines. The invention relates in particular to a polypeptide which comprises Nef or an immunogenic fragment thereof, and p17 Gag and/or p24 Gag or immunogenic fragments thereof, wherein when both p17 and p24 Gag are present there is at least one HIV antigen or immunogenic fragment between them. The polypeptide may also comprise Pol or RT or an immunogenic fragment thereof.

Abstract: This invention provides polypeptides of Helicobacter Pylori cytotoxin associated immunodominant (CAI) antigen. The invention also provides prophylactic and therapeutic vaccines comprising polypeptides of Helicobacter pylori CAI antigen, and methods for preparation. The invention also provides methods of treatment of Helicobacter pylori infection using these vaccines.

Abstract: The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a derivative of a full length S. aureus polypeptide. The full-length naturally occurring polypeptide is referred to herein as full length “ORF0826”. The SEQ ID NO: 1 derivative contains an alanine addition after the initial methionine. A His-tag derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.

Abstract: The present invention provides synthetic chimeric fimbrin peptides which induce an immunogenic response in animals to non-typable Haemophilus influenzae and that do not require tedious purification techniques. The synthetic chimeric fimbrin peptides reduce the severity of otitis media caused by Haemophilus influenzae. The synthetic chimeric fimbrin peptides are synthesized using commercially available peptide synthesizers. The synthetic chimeric fimbrin peptides comprises three peptide units. The first peptide unit is a subunit of the fimbrin protein. Preferably, the fimbrin subunit is comprised of the amino acids of Sequence ID No. 1 or Sequence ID No. 2. The second peptide unit is a t cell epitope, and preferably has the amino acid sequence of SEQ ID NO. 3. The third peptide unit is a linker peptide unit which joins the first and second peptide unit.

Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

Abstract: This invention relates to bispecific fusion proteins effective in viral neutralization. More specifically, such proteins have two different binding domains, an inducing-binding domain and an induced-binding domain, functionally linked by a peptide linker. Such proteins, nucleic acid molecules encoding them, and their production and use in preventing or treating viral infections are provided. One prototypical bispecific fusion protein is sCD4-SCFv(17b), in which a soluble CD4 fragment (containing domains D1 and D2) is fused to a single chain Fv portion of antibody 17b via a linker.

Abstract: The present invention relates to various pharmaceutical compositions that can be used as active or passive vaccines for the treatment or prevention of fungal disease. Methods for prevention and treatment of infectious and allergic fungal diseases in subjects using the pharmaceutical compositions of the present invention are also disclosed.

Abstract: Methods for increasing energy in men and women include ingesting internally, twice a day, products that include, for women, multivitamins, multiminerals, high-calcium bone support products, high-ORAC super food products, and enzymes, and, for men, multivitamins, multiminerals, prostate support products, high-ORAC super food products, and enzymes.

Abstract: The invention relates to compositions comprising a combination of ingredients including one or more oxidative fat metabolizers, neurotransmitters, algin or algin equivalents and medium chain triglycerides that are useful in regulating disorders and maintaining healthy metabolism. The compositions of the invention are useful in enhancing metabolism, burning fat, and enhancing energy.

Abstract: The present invention provides methods of inducing an immune response against Clostridium species in birds, for protecting birds from Clostridium infection, and/or for protecting birds from related disorders such as necrotic enteritis. The methods can be practiced in ovo and/or post-hatch. The invention further provides compositions and methods for delivery of a composition of this invention in ovo directly to the embryo body.

Abstract: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.

Abstract: Disclosed is a panel of biomarkers associated with angiogenesis, and the use of such biomarkers (genes, proteins, homologues and analogs thereof) to regulate angiogenesis. Methods for identifying compounds useful for regulating angiogenesis and conditions related thereto are disclosed.

Abstract: The present invention provides a DNA vaccine useful for treating breast cancer. Generally, the vaccine includes an expression vector that encodes a clinically relevant breast cancer-associated antigenic peptide and an IRM compound. The present invention also provides a DNA vaccine adjuvant that can increase the efficacy of a DNA vaccine. Generally, the adjuvant includes a TLR8-selective agonist.

Abstract: Dosage forms of a pharmaceutical composition comprising a sealed actives compartment containing a stable prostaglandin in a pharmaceutical composition for topical application to a patient are disclosed. Preferably, the prostaglandin compound is substantially uniformly dispersed in a delivery vehicle, and in certain embodiments the prostaglandin compound contains stabilizing agent comprising a moisture scavenger, an antioxidant and a chelating agent for metal ions. In certain embodiments the delivery vehicle is preferably substantially anhydrous, free of metal ions and oxygen and water. The improved compositions of the present invention are useful for treating medical conditions by providing a packed mono or multi-component dosage form that comprises a sealed section containing an active pharmaceutical ingredient and a delivery vehicle pharmaceutically compatible for topical delivery. The medical condition can be, for example male or female sexual dysfunction broadly and male erectile dysfunction specifically.

Abstract: Film-shaped medicaments administered orally, particularly buccally, for treating climacteric complaints. The medicaments contain estriol and/or at least one pharmacologically acceptable ester of estriol, either alone or in combination with at least one gestagen.

Abstract: Various pentosan polysulfate (PPS) formulations useful for treatment of osteoarthritis, interstitial cystitis, and other conditions of mammals are provided. These formulations showed improved resistance to degradation and discoloration and improved stability at physiological pH, even after sterilization. Capillary electrophoresis analysis of these formulations indicates that various formulations remain stable under conditions that caused degradation of PPS in prior art PPS formulations.

Abstract: This invention relates to the clear, substantially anhydrous, warming compositions containing one or more polyhydric alcohols. The invention also relates to the compositions that include at least one or more antioxidant or antioxidants in combination selected from the group consisting of tocopherol, ascorbic acid and butylated hydroxytoluene (BHT), to prevent oxidation of polyhydric alcohol combination that results in the development of odor.

Abstract: A cosmetic composition comprising a crosslinked particulate polyester polyol in a cosmetically acceptable carrier.

Abstract: The present invention relates to the cosmetic use of at least one 4-aminopiperidine compound of formula (I) in which: Alk1 and Alk2 denote a C1-C10 alkylene radical; Ar1 denotes a phenyl group optionally substituted with one or more radicals, which may be identical or different, chosen from —F, —CF3, —R1, —OR1, —NR1R2; Ar2 denotes a phenyl group optionally substituted with one or more radicals, which may be identical or different, chosen from —F, —CF3, —NR1R2; R denotes a hydrogen atom or a C1-C10 alkyl radical; R1 and R2 denoting a C1-C7 alkyl radical; and the salts, optical isomers and solvates thereof, as an agent for combating wrinkles, especially expression wrinkles, and/or for decontracting the skin and/or relaxing the features. The invention also relates to a cosmetic composition containing such a compound and to the corresponding novel compounds.

Abstract: A method for treating onychomycosis of a nail of an animal, which comprises a topical application of a solution to said nail, wherein said solution is comprised of at least one chemical agent capable of chelating iron metal ions

Abstract: The present invention relates to a hygienic and/or cosmetic and/or disinfectant composition including, at least one repulsive and/or repellent vermin-killer agent. According to the invention, the repulsive and/or repellent agent is a fatty acid. The present invention also relates to the use of the composition as a vermin-killer and/or repulsive and/or repellent treatment composition for arthropods, in particular insects such as flies, when treating and/or washing the udders and/or the dug of mammals.

Abstract: Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.

Abstract: The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement.

Abstract: An isolated protein complex is provided which includes a growth factor, growth factor binding protein and vitronectin. Preferably, the isolated protein complex includes an insulin-like growth factor-I, insulin-like growth factor binding protein-3 or insulin-like growth factor binding protein-5 and vitronectin. Also provided are methods of modulating cell proliferation and/or migration by administering said protein complex for the purposes of wound healing, skin repair and tissue replacement therapy. Conversely, by using agents that disrupt growth factor protein complexes formed in vivo, growth factor-driven cell proliferation and/or migration may be suppressed such as for the purposes of treating cancers, psoriasis, atherosclerosis and wounds prone to hypertrophic scarring.

Abstract: A material with a first state and a second state is applied to a surgical stapler. The stapler is applied to tissue in a surgical field while the material is in the first state. Subsequently, the second state is achieved by the material to secure the staple line. In some embodiments, bioactive agents are eluted from or into the staple line.

Abstract: The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement.

Abstract: A biodegradable biodelivery device is disclosed. The biodelivery device is formed from a polymer comprising the reaction product of a polyol and a polyacid. When exposed to water, the polymer degrades through hydrolysis. Of particular advantage, the polymer can be formed so as to be elastic and flexible. In one embodiment, the polymer is formed into a vaginal insert. As the polymer degrades, the polymer releases acid to a vaginal environment for decreasing the pH of the environment.

Abstract: Implant devices, systems and methods for insertion into a punctum of a patient optionally comprises a drug core and a sheath body disposed over the drug core. The drug core includes a therapeutic agent deliverable into the eye, and the sheath defines at least one exposed surface of the drug core. The exposed surface(s) of the drug core may contact a tear or tear film fluid and release the therapeutic agent at therapeutic levels over a sustained period when the implant is implanted for use. The implant may include a retention element to retain the drug core and sheath body near the punctum, optionally comprising a shape memory alloy that can resiliently expand. An occlusive element may be attached to the retention element to at least partially occlude tear flow through the canalicular lumen.

Abstract: The invention relates to the use of whey permeate, preferably sweet whey permeate and more preferably hydrolysed or partially-hydrolysed sweet whey permeate for the production of a pharmaceutical composition for prophylaxis or treatment of symptoms of metabolic syndrome, type-2 diabetes and secondary diseases, said composition being provided for a mammal.

Abstract: Asthma is an inflammatory disease of the airways in the lungs and bronchial tubes, the lower airway, that impairs breathing, causes wheezing, coughing and excess mucus and phlegm production. Asthma is the source of about one-fourth of all emergency room admissions. Throat lozenges and orally-retained liquids, such as syrups, containing magnesium are used in the invention to rapidly terminate asthma attacks and prevent asthma attacks. Magnesium lozenges and magnesium orally-retained liquids are effective in asthma rescue. Treatment of asthma with orally-retained magnesium, an essential human nutrient, is much safer than treatment by drugs yet they appear as effective as current drugs. An added benefit from magnesium treatment is relaxation. A preferred composition is 100 mg of magnesium from 400 mg magnesium chloride in a 4-gram lozenge. Magnesium lozenges or orally-retained liquids are administered as needed to treat asthma attacks or prevent incipient asthma attacks.

Abstract: This invention relates generally to the field of compositions for use as nutraceuticals, food additives or adjuncts to conventional drug therapies. In particular, the invention relates to compositions derived from natural oil sources which can be used for effective and inexpensive treatment of cardiovascular diseases, hypercholesterolemia, diabetes, cerebrovascular disease, neurological disorders, or liver abnormalities.

Abstract: A microscopic tagging material is provided comprised of a material to which has imparted at least two degrees of identification selected from the group consisting of physical configuration, elemental analysis, functional analysis, and polymeric composition analysis. The material may be a polymeric material, and the tagging material may comprise cut sections of an extruded polymer or polymer composition. The tagging material may be used as an authenticating means for a variety of compositions, coatings and/or products, such as food or drug products.

Abstract: The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microoganism.

Abstract: An animal diet and method of feeding an animal an amount of different pelleted feed compositions having different amounts of available energy per kilogram of the composition and a different specific ratio of kilocalories total available energy per gram amino acids throughout the animal lifecycles along with the different pelleted feed compositions and the methods of making those compositions that yield improved efficiencies in overall animal production methods.

Abstract: The antimicrobial thin film coating is a polyelectrolyte complex film applied to a substrate, with the polyelectrolyte complex material having biocidal properties. The polyelectrolyte complex material is formed from a first polyelectrolyte material having a positive charge, which is applied to the substrate in the form of a solution, and a second polyelectrolyte material having a negative charge, which is applied to the substrate following application of the first material. The positively charged polyelectrolytes and the negatively charged polyelectrolytes arrange themselves into a polyelectrolyte complex, rather than an alternating multi-layer structure, due to the electrostatic attraction between particles, allowing for the formation of a thin film with optimal coverage of the substrate.

Abstract: A method for treating a mouth sore opposite a tooth by adhering an oral patch on the tooth to speed healing and relieve pain. The oral patch is placed either directly on the portion of the tooth that comes into contact with the sore or is first place onto the sore and then adhered to the tooth. The patch may be a blob of hydrophilic gums. If certain medications are applied to a mouth sore using an oral patch that delivers the medication for at least 30 minutes and the patches are used for at least two or more hours per day, the method reduces the healing time for mouth sores from typical 10-14 days to 1-5 days. The method can be used with various antimicrobials, glucocorticoids or anthihistamines incorporated into the patch that reduce inflammation or speed the healing of mouth sores.

Abstract: A patch is disclosed which is capable of dispensing a scent. The patch includes a pad impregnated with a liquid and the pad is located between a liquid-impermeable barrier layer and a vapor permeable carrier layer. An evaporative interface is situated between the pad and the carrier layer and represents a location where the liquid is transformed into a vapor as it contacts air. A plurality of vaporization ports extend from the evaporative interface to an upper surface of the carrier layer and provide an escape route through which the vapor can escape. The patch is designed to be housed in a package until it is ready to be used. When the package is opened, the patch will emit vapors which are released into the surrounding environment over a desired period of time.

Abstract: The invention concerns a transdermal therapeutic system containing ergoline derivatives, preferably lisuride, with a stabilized ergoline compound. Stabilization of the oxidation sensitive ergoline combination is done through a combination of at least one fat-soluble, radical-trapping antioxidant, preferably Di-tert.-butylmethylphenols, Di-tert.-butylmetoxyphenols, tocopherols or ubichinones and a basic polymer. Use of a transdermal therapeutic system (TTS) comprising a pharmaceutical layer containing at least one matrix having an active ingredient and/or an active ingredient reservoir; a diffusion barrier that is permeable to said active ingredient and arranged on the skin side of the active ingredient reservoir; and an ergoline derivative or salt thereof as an active ingredient for producing an agent for obtaining and maintaining the circadian rhythm under dopamine therapy.

Abstract: A process for preparing a vesicle composition based upon mixing an organopolysiloxane having at least one hydrophilic substituent group, a water miscible volatile solvent, and water is disclosed. The vesicle compositions produced by the method are useful in various personal, household, and health care applications.

Abstract: This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of genes encoding proteins involved in deafness caused by dominant negative mechanism of action by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of genes involved in deafness caused by dominant negative mechanism of action.

Abstract: The present disclosure provides oral dosage forms comprising an antiplatelet agent and an acid inhibitor, as well as methods of treating subjects with an antiplatelet agent and an acid inhibitor.

Abstract: Disclosed herein are methods of treating at least one bacterial infection, such as lower gastrointestinal infections, comprising orally administering a pharmaceutical composition comprising tigecycline. The composition can take solid or liquid forms, such as solutions, dispersions, or solid forms comprising tigecycline having at least one enteric coating.

Abstract: A multi-particulate oral dosage form, comprising a plurality of pellets, the pellets comprising a core having disposed thereon a core composition layer, the core composition layer comprising an active agent, and a sustained-release coating disposed on the core composition layer, wherein the sustained-release coating comprises a first polymer comprising a copolymer of acrylic and methacrylic esters comprising quaternary ammonium groups and having a ratio of quaternary ammonium groups to neutral meth(acrylic) esters of 1:40 and optionally a second polymer comprising a copolymer of acrylic and methacrylic esters comprising quaternary ammonium groups and having a ratio of quaternary ammonium groups to neutral meth(acrylic) esters of 1:20, wherein the ratio of the first polymer to the second polymer is about 50:50 to about 100:0, and wherein the first and second polymer comprise about 20 wt % to about 90 wt % of the total weight of the sustained-release coating; and about 10 wt % to about 50 wt % of colloidal sili

Abstract: The invention provides pills and tablets having lubricious coating deposited over the outer surface of the pills and the tablets.