Patents Issued in November 13, 2007
  • Patent number: 7294470
    Abstract: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3? side of a target SNP base is C, while a base adjacent with one base spaced apart is G. According to the present invention, the 3? end base is designed to be the base corresponding to SNP; the second and the third bases from the 3? end to be 5?-AT-3?, 5?-TT-3?, 5?-GA-3? or 5?-GT-3?; and the base sequence of from the fourth from the 3? end to the 5? end base to be completely complementary to the sequence of from a base three bases away from the target SNP base on the 3? side to a desired base.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: November 13, 2007
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventors: Hidenobu Yaku, Hiroaki Oka, Tetsuo Yukimasa
  • Patent number: 7294471
    Abstract: A method for purifying cancer-specific Proliferating Cell Nuclear Antigen (csPCNA) is described, as well as an immunoassay based thereon.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: November 13, 2007
    Assignee: csKeys, LLC
    Inventors: Linda H. Malkas, Robert J. Hickey, Pamela E. Bechtel, Min Park, Derek J. Hoelz, Dragana Tomic, Lauren Schnaper
  • Patent number: 7294472
    Abstract: This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor. Assays, methods of treatment and other methods developed in conjunction with these methods also are disclosed.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: November 13, 2007
    Assignee: Caden Biosciences
    Inventors: Annette Gilchrist, Heidi M. Hamm
  • Patent number: 7294473
    Abstract: Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have been isolated, identified, and analyzed for their functions. The cell surface molecules are expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes, and induce cell adhesion. Antibodies against the cell surface molecules significantly ameliorate pathological conditions of autoimmune diseases and allergic diseases.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: November 13, 2007
    Assignee: Japan Tobacco Inc.
    Inventors: Takuya Tamatani, Katsunari Tezuka
  • Patent number: 7294474
    Abstract: Functional assays for identifying compounds that activate or modulate the activation of the T1R2/T1R3 (sweet) taste receptor are provided. These assays detect the effect of one or more compounds on the activation of T1R2/T1R3 (sweet) taste receptor or on the activation of T1R2/T1R3 sweet taste receptor by another, compound e.g., saccharin or another artificial or natural sweetener. These assays preferably are cell-based functional assays and typically use cells, e.g., HEK-293 cells that stably express a G protein such as G?15, G?16 or gustducin. Compounds identified in the disclosed functional assays are potentially useful as additives in compositions for human or animal consumption.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: November 13, 2007
    Assignee: Senomyx, Inc.
    Inventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
  • Patent number: 7294475
    Abstract: A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: November 13, 2007
    Assignee: Takeda Chemical Industries, Limited
    Inventors: Hideaki Tojo, Nozomi Katayama, Shigeya Kakimoto
  • Patent number: 7294476
    Abstract: Several lines of evidence have shown a role for the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the development of spinal hyperalgesia. However, the roles of effectors for cGMP are not fully understood in the processing of pain in the spinal cord. cGMP-dependent protein kinase (PKG) I? but not PKGI? was localized in the neuronal bodies and processes, and was distributed primarily in the superficial laminae of the spinal cord. Intrathecal administration of an inhibitor of PKGI?, Rp-8-[(4-Chlorophenyl)thio]-cGMPS triethylamine, produces significant antinociception. Moreover, PKGI? protein expression was dramatically increased in the lumbar spinal cord after noxious stimulation. This upregulation of PKGI? expression was completely blocked not only by a neuronal NO synthase inhibitor, and a soluble guanylate cyclase inhibitor, but also by an N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: November 13, 2007
    Assignee: The John Hopkins University
    Inventors: Roger A. Johns, Yuanxiang Tao
  • Patent number: 7294477
    Abstract: The present invention is related to novel nucleoli sequences encoding a louse allergen and a methods for diagnosing, treating and preventing lice infestation and associated allergic disease with the nucleoli sequences and protein allergen of the invention. The present invention also relates to kits for diagnostic assays.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: November 13, 2007
    Assignee: Ovita Limited
    Inventors: Alexander Terrance Pfeffer, Charles Bix Shoemaker
  • Patent number: 7294478
    Abstract: An apparatus and method are provided for shipping, storing, and high-throughput processing of microarrays. An exemplary microarray cartridge according to the present invention includes a body having a cavity defined by an outer surface and two dimple features in fluid communication with the cavity. The cavity includes at least one ledge for supporting a microarray of biological probes, and a reaction chamber defined at least in part by the ledge. A plate covers the cavity and sealingly attaches to the outer surface of the body. Ports in the plate or the dimple features allow introduction of sample, reaction and wash solutions into the reaction chamber such that the solutions contacts the probes on the microarray. The disposable microarray cartridges of the present invention are used to package and store microarrays prior to use and to process microarrays in a high-throughput manner. The footprint of the cartridge is designed to be compatible with standard robotic formats or standard re-formatting approaches.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: November 13, 2007
    Assignee: Rosetta Inpharmatics LLC
    Inventor: John Hinchcliffe
  • Patent number: 7294479
    Abstract: Provided are compositions and methods for accurate determination of the concentration of anticoagulant in a sample such as a blood or plasma sample. The compositions can contain a Factor X compound and Factor V compound, and additional components as well. Methods for performing the assay include one-step methods in which a sample is added to a coagulation assay composition, and time is monitored from the point of adding the sample and coagulation assay composition to an endpoint, such as clot formation.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: November 13, 2007
    Inventor: Thye Yin
  • Patent number: 7294480
    Abstract: High throughput screening assays for the identification of potential therapeutic agents able to modulate the activity of enzymes of fatty acid biosynthesis, especially desaturases and/or elongases, are disclosed along with therapeutic uses of the agents identified by such assays for the prevention and/or treatment of diseases related to fatty acid metabolism. Substrates useful in such assays are also described.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: November 13, 2007
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Michael D. Winther, Mark P. Gray-Keller
  • Patent number: 7294481
    Abstract: A method for producing recombinant proteins, preferably fusion proteins comprising an Fc portion of an immunoglobulin molecule, more preferably fusion proteins comprising an extracellular domain of a tumor necrosis factor receptor fused to the Fc portion of an immunoglobulin molecule, is disclosed. The method of the present invention allows a reduction of misfolding of the protein, thereby giving rise to a higher yield of the desired protein.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: November 13, 2007
    Inventor: Victor P. Fung
  • Patent number: 7294482
    Abstract: The invention provides isolated nucleic acid molecules, designated ELVIS-1, ELVIS-2, and ELVIS-3 (for Epidermal Growth Factor-Like Variant In Skin-1, 2, and 3). ELVIS nucleic acid molecules encode wholly secreted and transmembrane proteins with homology to EGF and TGF-?. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The ELVIS nucleic acids of the present invention are useful as modulating agents in regulating a variety of cellular processes, and are particularly useful for diagnostic, screening and therapeutic methods for the treatment of skin conditions, such as for wound healing.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: November 13, 2007
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Samantha J. Busfield, David P. Gearing
  • Patent number: 7294483
    Abstract: A process is described for producing a polypeptide heterologous to E. coli wherein E. coli cells comprising nucleic acid encoding the polypeptide are cultured in a culture medium while feeding to the culture medium a transportable organophosphate, such that the nucleic acid is expressed. The polypeptide is then recovered from the cells.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: November 13, 2007
    Assignee: Genentech, Inc.
    Inventors: Woon-Lam Susan Leung, James R. Swartz
  • Patent number: 7294484
    Abstract: An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative asparagine ratio of less than about 2; iii) a molar cumulative glutamine to cumulative total amino acid ratio of less than about 0.2; iv) a molar cumulative inorganic ion to cumulative total amino acid ratio between about 0.4 to 1; or v) a combined cumulative glutamine and cumulative asparagine concentration between about 16 and 36 mM, is provided. The use of such a system allows high levels of protein production and lessens accumulation of certain undesirable factors such as ammonium and/or lactate. Additionally, culture methods including a temperature shift, typically including a decrease in temperature when the culture has reached about 20-80% of it maximal cell density, are provided.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: November 13, 2007
    Assignee: Wyeth Research Ireland Limited
    Inventors: Denis Drapeau, Yen-Tung Luan, James R. Mercer, Wenge Wang, Daniel R. Lasko
  • Patent number: 7294485
    Abstract: Novel sequences for calcium channel ?2?-2 and ?2?-3 subunits are provided. Also provided are cell lines that express the novel calcium channel subunits of the invention. These cells may be used for identifying compounds capable of stimulating or inhibiting the activation of the calcium channels.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: November 13, 2007
    Assignee: Neuromed Pharmaceuticals Ltd.
    Inventors: David Parker, Xianghong Xu, Afsheen Khawaja, Terrance P. Snutch
  • Patent number: 7294486
    Abstract: There is described a process for the synthesis of a fluoronucleoside compound, said process comprising mixing a substrate and an enzyme from Streptomyces cattelya as catalyst. The process may be used to produce an 18F labelled fluoronucleoside compound. There is also described an enzyme derived from Streptomyces cattelya which has the capacity to catalyse the synthesis of a fluoronucleoside compound.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: November 13, 2007
    Assignee: The University Court of the University of St. Andrews
    Inventors: David O'Hagan, Christoph Schaffrath
  • Patent number: 7294487
    Abstract: The present invention relates to a method for the detection of gene expression and analysis of both known and unknown genes. The invention is a highly sensitive, rapid and cost-effective means of monitoring gene expression, as well as for the analysis and quantitation of changes in gene expression for a defined set of genes and in response to a wide variety of events.” It is an important feature of the present invention that no single molecular species of cDNA gives rise to more than one fragment in the collection of products which are subsequently amplified and representative of each expressed gene. This achievement is facilitated by immobilizing the cDNA prior to digesting and then digesting with sequentially with two frequently cutting enzymes. Linker oligomers are ligated to each cut site following the respective digestion. Primers, complementary to the oligomer sequence with an additional 3? variable sequence are used to amplify the fragments.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: November 13, 2007
    Assignee: Board of Regents, the University of Texas System
    Inventors: Michael C. MacLeod, C. Marcelo Aldaz, Sara S. Gaddis
  • Patent number: 7294488
    Abstract: The present invention provides amplification and hybridisation method for detecting and typing human papillomavirus (HPV), and the primers and hybridisation probes used in the method. The invention relates to a concrete part of the HPV genome, which is suitable for designing HPV genus-specific and HPV genotype-specific hybridisation oligonucleotide probes.
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: November 13, 2007
    Assignee: Genoid KFT
    Inventors: Csaba Jeney, Tibor Takács
  • Patent number: 7294489
    Abstract: Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting Mycobacterium species using the oligonucleotides in in vitro nucleic acid amplification are disclosed.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: November 13, 2007
    Assignees: Gen-Probe Incorporated, BioMerieux S.A.
    Inventors: Steven T. Brentano, Markus T. Jucker, Francisco D. Delgado, Philippe Cleuziat, Marc Rodrigue
  • Patent number: 7294490
    Abstract: The invention concerns a method for detecting micro-organisms constituting a flora of micro-organisms, whereof at least part of the elements has a common operon. The invention is characterised in that it consists in identifying the elements of said flora by studying the intergenetic sequence of said operon, and the support exhibiting nucleic acids capable of hybridizing said intergenetic sequence.
    Type: Grant
    Filed: November 28, 2003
    Date of Patent: November 13, 2007
    Assignee: Compagnie Gervais Danone
    Inventors: Pierre-Charles Romond, Johanne Renaud, legal representative, Mathias Renaud, legal representative, Monique Alric, Olivier Meiniel, Lionel Ballut, Michel Renaud, deceased
  • Patent number: 7294491
    Abstract: The present invention provides a method for producing L-glutamic acid by fermentation, by culturing in a liquid medium a microorganism that can metabolize a carbon source at a specific pH, and wherein said medium contains a carbon source and L-glutamic acid at a saturation concentration, and wherein said microorganism is able to cause accumulation of an amount of L-glutamic acid in a liquid medium having said pH, wherein said amount exceeds the amount of L-glutamic acid at said saturation concentration when the pH of the medium is controlled so that L-glutamic acid is precipitated, making L-lysine exist in the medium when L-glutaminc acid concentration is lower than the concentration at which natural crystallization of L-glutamic acid occurs, and precipitating the ?-form crystals of L-glutamic acid.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: November 13, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hiroshi Ueda, Kunihiko Toumori
  • Patent number: 7294492
    Abstract: The present invention is directed to the use of yeasts to produce spiroketal fragrance materials. The preferred yeasts used in the method of the invention are Bensingtonia ciliate and Cryptococcus laurentii.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: November 13, 2007
    Inventors: Kwang-Pil Choi, Michael P. McLean, John Lyons Buckley, III, Mark L. Dewis
  • Patent number: 7294493
    Abstract: The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitriles to the corresponding amides, and the amidase is useful for hydrolysis of amides to the corresponding carboxylic acids. Also provided are transformed host cells containing polynucleotides for expressing the nitrile hydratase or amidase enzymes from Comamonas testosteroni 5-MGAM-4D.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: November 13, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Mark S. Payne, Robert DiCosimo, John E. Gavagan, Robert D. Fallon
  • Patent number: 7294494
    Abstract: RecA protein mutants and RecA homolog protein mutants which contain one or more mutations in the MAW motif are presented. The mutants rely on replacement of wildtype amino acid residues in the MAW motif with specific replacement residues to alter the three-dimensional structure of the MAW motif and to change the protein's DNA-binding properties. Three classes of mutants are described: mutants which will reduce the protein's dependence on ATP to initiate DNA-binding; mutants which more tightly bind DNA; and combination mutants which possess both of these properties.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: November 13, 2007
    Inventor: Alberto Roca
  • Patent number: 7294495
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: November 13, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, Colin K. Watanabe, William I. Wood
  • Patent number: 7294496
    Abstract: A cloned of a human brain lysophospholipid-specific lysophospholipase enzyme molecule, its potential use for treatment of a host of diseases and method of inactivation are disclosed. Also disclosed are its distribution in tissue sand detailed kinetic analysis. hLysoPLA has a single substrate binding site and a surface recognition site. In contrast to many nonspecific lipolytic enzymes that exhibit lysophospholipase activity, hLysoPLA hydrolyzes only lysophospholipids and has no other significant enzymatic activity.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: November 13, 2007
    Assignee: The Regents of the University of California
    Inventors: Edward A. Dennis, Aijun Wang
  • Patent number: 7294497
    Abstract: Isolated nucleic acid sequences and amino acid sequences for soluble, ?-N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are provided. An isolated mutant bacteria which forms biofilm colonies which tightly adhere to surface but which are unable to release cells into the medium or spread over the surface is also provided. In additions, methods are described for modulating detachment of bacterial cells from biofilm by mutating soluble,?-N-acetylglucosamimidase or altering its expression or activity are also provided. Also provided are compositions, methods and devices for preventing, inhibiting and treating bacterial infections.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: November 13, 2007
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventor: Jeffrey B. Kaplan
  • Patent number: 7294498
    Abstract: A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry, pharmaceutical industry and in the textile industry, detergent industry and in the baking industry.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: November 13, 2007
    Assignee: Verenium Corporation
    Inventors: Edward J. Bylina, Ronald V. Swanson, Eric J. Mathur, David E. Lam
  • Patent number: 7294499
    Abstract: The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN? subtilase and to TY145 and BPN? variants having altered properties as compared to the parent TY145/BPN? subtilase.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: November 13, 2007
    Assignee: Novozymes A/S
    Inventors: Allan Svendsen, Henriette Draborg
  • Patent number: 7294500
    Abstract: The invention relates to Infectious Bursal Disease Virus (“IBDV”) and vaccines therefor. Provided are infectious recombinant Infectious Bursal Disease Virus (“rIBDV”) essentially incapable of growing in a cell that is not derived from a bursa cell, or an infectious rIBDV having retained at least part of the very virulent characteristics of a very virulent Infectious Bursal Disease Virus (“vvIBDV”).
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: November 13, 2007
    Assignee: ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V.
    Inventors: Hendrik Johannis Boot, Anna Agnes H. M. ter Huurne, Bernardus Petrus H. Peeters
  • Patent number: 7294501
    Abstract: A use of an inoculum of a geldanamycin-producing strain able to survive in a plant rhizosphere as a biocontrol of common scab affecting the plant and a method for biocontrolling common scab comprising the use of such strain. A biologically pure culture of a Streptomyces strain deposited at the American Type Culture Collection (ATCC) Accession number BAA-668, or a variant thereof.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: November 13, 2007
    Assignee: Universite De Sherbrooke
    Inventors: Carole Beaulieu, Julie Beauséjour, Sonya Agbessi
  • Patent number: 7294502
    Abstract: The invention relates to a device for collecting samples of fluids, in particular of body fluids such as saliva, said device comprising an absorbent pad and two housing parts which are connected to the latter in a movable manner and can enclose the absorbent pad. The device permits easy and safe handling when taking a sample and when transferring the sample for testing for an analyte in the sample. The device can also be handled hygienically and safely by persons not trained in taking samples.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: November 13, 2007
    Assignee: EnviteC-Wismar GmbH
    Inventors: Martin Eckermann, Martin Ullmann, Bernd Lindner
  • Patent number: 7294503
    Abstract: A microfluidic device for analyzing and/or sorting biological materials (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for its use are provided. The device and methods of the invention are useful for sorting particles, e.g. virions. The invention is also useful for high throughput screening, e.g. combinatorial screening. The microfluidic device comprises a main channel and an inlet region in communication with the main channel at a droplet extrusion region. Droplets of solution containing the biological material are deposited into the main channel through the droplet extrusion region. A fluid different from and incompatible with the solution containing the biological material flows through the main channel so that the droplets containing the biological material do not diffuse or mix.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: November 13, 2007
    Assignee: California Institute of Technology
    Inventors: Stephen R. Quake, Todd Thorsen
  • Patent number: 7294504
    Abstract: DNA compositions that mediate gene silencing via RNA interference are provided. Also provided are methods of using such compositions to silence gene expression in a cell.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: November 13, 2007
    Assignee: Allele Biotechnology & Pharmaceuticals, Inc.
    Inventor: Jiwu Wang
  • Patent number: 7294505
    Abstract: The present invention provides a vector system which can be stably translocated from the cytoplasm of a cell to the nucleus where it is a stable nuclear episomal vector. A basic vector system according to the present invention is generally composed of nucleic acid encoding (a) a promoter functional both in cytoplasm and nucleus, operably linked to (b) a plasmid maintenance/translocation factor and (c) an origin of replication.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: November 13, 2007
    Assignee: GHC Research Development Corporation
    Inventors: Thomas E. Wagner, Xianzhang Yu
  • Patent number: 7294506
    Abstract: The subject invention relates in part to tobacco chloroplast transformation vectors comprising a multi-gene operon that generates a polycistron that encodes a biopharmaceutical protein and a chaperonin.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: November 13, 2007
    Inventors: Henry Daniell, William Moar
  • Patent number: 7294507
    Abstract: The present invention includes nucleic acid molecules comprising an artificial chromosome and an avian ovomucoid gene expression controlling region operably linked to the coding sequence of a useful polypeptide.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: November 13, 2007
    Assignee: AviGenics, Inc.
    Inventors: Alex J. Harvey, Markley C. Leavitt, Youliang Wang
  • Patent number: 7294508
    Abstract: A method for isolating an inner cell mass comprising the steps of immobilizing a blastocyst stage embryo having a zona pellucida, trophectoderm, and inner cell mass, creating an aperture in the blastocyst stage embryo by laser ablation, and removing the inner cell mass from the blastocyst stage embryo through the aperture. The aperture is through the zona pellucida and the trophectoderm. The laser ablation is acheived using a non-contact diode laser. The inner cell mass removed from the blastocyst stage embryo is used to establish human Embryonic Stem Cell lines.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: November 13, 2007
    Assignee: Reliance Life Sciences Pvt. Ltd.
    Inventors: Firuza Rajesh Parikh, Satish Mahadoerao Totey, Shailaja Anupam Saxena
  • Patent number: 7294509
    Abstract: This invention relates to new immortalized human pre-adipose cell lines capable of differentiating into adipose cells and methods of obtaing the immortalized cells. In particular, the present invention pertains to immortalized pre-adipocyte cell lines derived from white adipose tissue and methods of producing the cell lines. The immortalized pre-adipocyte cells are capable of maturing into immortalized white adipose cells useful in developing drugs, food ingredients and supplements against obesity, diabetes and cardiovascular diseases.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: November 13, 2007
    Assignee: Nestec S.A.
    Inventors: Christian Darimont, Katherine Mace, Andrea Pfeifer
  • Patent number: 7294510
    Abstract: The present invention provides a method for producing motor neurons and GABAergic neurons characterized by including suspension-culturing embryonic stem cells in the presence or absence of a protein noggin to form embryoid bodies, selectively amplifying into neural stem cells from them by suspension culture in the presence of a fibroblast growth factor and a sonic hedgehog protein, and then differentiating the same. According to this method, at least motor neurons and GABAergic neurons can be systemically and efficiently produced from ES cells. Selective acquisition of neurons would be applicable to transplant therapy for amyotrophic lateral sclerosis, Huntington's chorea, Alzheimer's disease, etc.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: November 13, 2007
    Assignee: Japan Science and Technology Corporation
    Inventors: Hideyuki Okano, Takuya Shimazaki
  • Patent number: 7294511
    Abstract: Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial chromosomes, into cells, and are practiced in vitro and in vivo.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: November 13, 2007
    Assignee: Chromos Molecular Systems, Inc.
    Inventors: Gary deJong, Sandra Louise Vanderbyl, Volker Oberle, Dirk Hoekstra
  • Patent number: 7294512
    Abstract: A multi-analyte calibration solution having known amounts of sodium carbonate, ammonium bicarbonate, and ethyl alcohol, with pH adjusted within a range between about 7.8 and 8.4.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: November 13, 2007
    Assignee: Dade Behring Inc.
    Inventor: Douglas Paul Clark
  • Patent number: 7294513
    Abstract: A method and apparatus is described by which means molecules in suspension may be characterized in terms of the size and mass distributions present. As a sample solution is separated by centrifugal means, it is illuminated at a particular radial distance from the axis of rotation by a fine, preferably monochromatic, light beam. Despite the high resolution of such devices, a key problem associated with most separators based upon use of centrifugal forces is the difficulty in deriving the absolute size and/or molar mass of the separating molecules. By integrating means to detect light scattered, over a range of scattering angles, from samples undergoing centrifugal separation, molecular sizes in the sub-micrometer range may be derived, even in the presence of diffusion. Adding a second light beam at a displaced rotational angle, preferably of an ultraviolet wavelength, that intersects the sample at the same radial region as the first beam permits determination of the molecular concentration at that region.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: November 13, 2007
    Assignee: Wyatt Technology Corporation
    Inventor: Philip J. Wyatt
  • Patent number: 7294514
    Abstract: The invention provides a diagnostic or prognostic assay method for Alzheimer's Disease by assaying a body fluid sample or a test sample derived therefrom for holo-trancobalamin II.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: November 13, 2007
    Assignee: Axis Shield ASA
    Inventor: Lars Örning
  • Patent number: 7294515
    Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: November 13, 2007
    Assignee: Baylor College of Medicine
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Patent number: 7294516
    Abstract: A test pattern and a method of controlling a CMP using the same are provided. The test pattern is disposed on a monitoring region of a semiconductor substrate having a main region and a monitoring region. The test pattern includes a planar region and a pattern region. The method comprises setting a correlation between a step difference of a test pattern and an etched thickness of a main pattern, then applying the CMP to a semiconductor substrate having the test pattern and the main pattern for a predetermined time. The step difference of the test pattern is measured and the etched thickness of the main pattern, which corresponds to the step difference of the test pattern, is determined from the correlation. A polishing time is corrected by comparing the determined etched thickness of the main pattern with a reference value, and the corrected polishing time is applied to a subsequent lot or subsequent substrate.
    Type: Grant
    Filed: February 10, 2005
    Date of Patent: November 13, 2007
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jeong-Heon Park, Bo-Un Yoon, Jae-Dong Lee
  • Patent number: 7294517
    Abstract: It is characteristic of an organic material suited to an interlayer insulating film to transmit vapor therethrough and to be liable to absorb moisture, and the material has a disadvantage that it is extremely susceptible to oxygen and moisture to be readily deteriorated no matter whether it is low-molecular or high-molecular. Further, alkali metal or alkaline earth metal is used for a positive electrode or a negative electrode of a light emitting element, and these are liable to be oxidized by oxygen. Thus moisture is responsible for deterioration of a light emitting element and for failure such as dark spots or the like.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: November 13, 2007
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Toru Takayama, Hirokazu Yamagata, Akihiko Koura, Shunpei Yamazaki
  • Patent number: 7294518
    Abstract: The present invention provides a photoresist stripper including about 5 wt % to about 20 wt % alcohol amine, about 40 wt % to about 70 wt % glycol ether, about 20 wt % to about 40 wt % N-methyl pyrrolidone, and about 0.2 wt % to about 6 wt % chelating agent.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: November 13, 2007
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Hong-Sick Park, Jong-Hyun Jeong, Suk-Il Yoon, Seong-Bae Kim, Wy-Yong Kim, Soon-Beom Huh, Byung-Uk Kim
  • Patent number: 7294519
    Abstract: Provided are a semiconductor light-emitting device having nano-needles and a method of manufacturing the same. The provided semiconductor light-emitting device improves the extraction efficiency of photons, and includes a gallium nitride (GaN) group multi-layer and nano-needles grown on the GaN group multi-layer. The nano-needles improve the extraction efficiency of photons.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: November 13, 2007
    Assignee: Luxpia Co., Ltd.
    Inventors: Jong Soo Lee, Min Sang Lee, Young Ki Lee