Patents Issued in June 24, 2008
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Patent number: 7390606Abstract: The toner includes emulsion aggregation toner particles having a core and a shell. The core includes binder including a first non-crosslinked styrene acrylate polymer and a crosslinked styrene acrylate polymer, at least one colorant, at least one wax, and aluminized silica. The shell includes a second non-crosslinked styrene acrylate polymer that is preferably the same as the non-crosslinked styrene acrylate polymer of the core. The aluminized silica is advantageously used as a coagulant in the emulsion aggregation formation of the toner. A developer containing the toner and a method of forming an image using the toner are also described.Type: GrantFiled: October 17, 2005Date of Patent: June 24, 2008Assignee: Xerox CorporationInventors: Raj D. Patel, Edward G. Zwartz, Biritawit Asfaw
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Patent number: 7390607Abstract: To provide a toner production process in which at least radically polymerizable monomers are polymerized in at least one of a supercritical fluid and a subcritical fluid to thereby produce toner particles, wherein a polymer of the radically polymerizable monomers is insoluble in at least one of the supercritical fluid and the subcritical fluid.Type: GrantFiled: July 12, 2006Date of Patent: June 24, 2008Assignee: Ricoh Company, Ltd.Inventors: Chiaki Tanaka, Masayuki Ishii
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Patent number: 7390608Abstract: In a first aspect, silicon polymers are provided that have controlled ratio of silanol (Si—OH) moieties:Si atoms and/or a controlled amount of alkaline aqueous-solubilizing groups. Si-polymers of the invention are particularly useful as a photoresist resin component. In a further aspect, halogenated sulfonamide and thiol compounds and Si-containing polymers comprising such reacted monomers are provided.Type: GrantFiled: October 21, 2003Date of Patent: June 24, 2008Assignee: Rohm and Haas Electronic Materials LLCInventors: George G. Barclay, Subbareddy Kanagasabapathy
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Patent number: 7390609Abstract: New polymers are provided that have non-carbon tetravalent species (Si, Ti, Ge, Zr, Sn) and photoimageable compositions that contain such polymers. Preferred polymers are organic, e.g. one or more polymer repeat units comprise carbon atom(s). Particularly preferred are polymers that comprise SiO2 or TiO2 repeat units and which can be highly useful as a resin component of resists imaged at short wavelengths such as sub-300 nm and sub-200 nm.Type: GrantFiled: March 3, 2004Date of Patent: June 24, 2008Assignee: Rohm and Haas Electronic Materials LLCInventors: Anthony Zampini, Tao Zhang, Jaihyoung Lee
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Patent number: 7390610Abstract: The present disclosure discloses a color former phase. According to one exemplary embodiment discussed herein, an exemplary color former phase includes at least one color former, a radiation absorber, and an acrylic resin, in which the color former, the radiation absorber, and the acrylic resin form an amorphous solid.Type: GrantFiled: October 18, 2005Date of Patent: June 24, 2008Assignee: Hewlett-Packard Development Company, L.P.Inventor: Michael J. Day
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Patent number: 7390611Abstract: A photoresist coating composition that includes a compound represented by Formula 1 and an aqueous solvent, and a method for forming a fine pattern by coating the composition on a photoresist pattern to effectively reduce a size of a photoresist contact hole and a space, which can be applied to all of the semiconductor processes.Type: GrantFiled: November 2, 2005Date of Patent: June 24, 2008Assignee: Hynix Semiconductor Inc.Inventor: Geun Su Lee
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Patent number: 7390612Abstract: There is provided a positive type resin composition comprising (A) a resin component comprising within the principal chain a structural unit derived from a (meth)acrylate ester and incorporating an acid dissociable, dissolution inhibiting group containing a polycyclic group on an ester side chain section, for which the solubility in alkali increases under the action of acid, (B) an acid generator component which generates acid on exposure, and (C) an organic solvent, wherein the component (A) comprises both a structural unit derived from a methacrylate ester and a structural unit derived from an acrylate ester. According to such a resist composition, a resist pattern can be formed which displays little surface roughness and line edge roughness on etching, and also offers excellent resolution and a wide depth of focus range.Type: GrantFiled: February 2, 2006Date of Patent: June 24, 2008Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Takeshi Iwai, Naotaka Kubota, Satoshi Fujimura, Miwa Miyairi, Hideo Hada
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Patent number: 7390613Abstract: The present application relates to a compound of formula Ai Xi Bi where Ai and Bi are each individually an organic onium cation; and Xi is anion of the formula ?O3S—CF2CF2OCF2CF2—SO3?. The compounds are useful as photoactive materials.Type: GrantFiled: December 4, 2006Date of Patent: June 24, 2008Assignee: AZ Electronic Materials USA Corp.Inventors: M. Dalil Rahman, David L. Rentkiewicz
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Patent number: 7390614Abstract: A lithographic projection apparatus includes an alignment sensor having an electron beam source constructed and arranged to provide an electron beam for impinging on an alignment marker on a substrate, and a back-scattered electron detector constructed and arranged to detect electrons back-scattered from the alignment marker. The alignment sensor is independent of the projection system and projection radiation, and is an off-axis alignment sensor.Type: GrantFiled: March 29, 2005Date of Patent: June 24, 2008Assignee: ASML Netherlands B.V.Inventors: Johannes G. Gijsbertsen, Pieter W. H. De Jager, Michiel D. Nijkerk
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Patent number: 7390615Abstract: An integrated circuit, a fuse therefor and fuse opening method are disclosed. The method implements fuse opening using a wet etchant. As a result, there is no explosion that causes damage to surrounding material. In addition, use of the wet etchant allows positioning of a fuse in any metal layer including any non-last metal layer, thus increasing design possibilities.Type: GrantFiled: June 20, 2003Date of Patent: June 24, 2008Assignee: International Business Machines CorporationInventor: Stephen E. Greco
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Patent number: 7390616Abstract: A method for post lithographic critical dimension shrinking of a patterned semiconductor feature includes forming an overcoat layer over a patterned photoresist layer, and removing portions of the overcoat layer initially formed over top surfaces of the patterned photoresist layer. The remaining portions of the overcoat layer on sidewalls of said patterned photoresist layer are reacted so as to chemically bind the remaining portions of the overcoat layer on the sidewalls.Type: GrantFiled: January 12, 2005Date of Patent: June 24, 2008Assignee: International Business Machines CorporationInventor: Colin J. Brodsky
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Patent number: 7390617Abstract: The invention includes a process for forming a laser pixel array useful with a pump-beam, comprising: a) forming a layer containing a formamide of an amino dye compound on a support wherein the layer absorbs light outside the laser wavelength and predominantly outside the pump-beam wavelength range; and b) subjecting the layer to UV radiation in the areas of the layer where it is desired to be free of pixels for a time sufficient to shift the absorption envelope of the areas into the pump-beam wavelength range. The invention also provides for unimolecularly forming an image or an information record and a composition of matter. The invention provides methods for forming filters, images or information records having a smooth surface and in particular for forming a pixel region pattern for use with an Organic VCSEL that would ease manufacturing.Type: GrantFiled: June 30, 2004Date of Patent: June 24, 2008Assignee: Eastman Kodak CompanyInventors: J. Ramon Vargas, Denis Y. Kondakov, Keith B. Kahen
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Patent number: 7390618Abstract: Minute structures are obtained by exposing a process target material and changing the shape thereof by relatively shifting a laser beam or electron beam against the process target material and simultaneously repeating irradiation in an intermittent manner. A plurality of minute convex or concave shapes are formed on the process target material by employing a branching element for branching a single beam into a plurality of beams; a parallel element for converting said plurality of beams into beams which respectively advance in parallel; and a condensing element for condensing the plurality of beams to the process target material and generating a plurality of minute spots thereon.Type: GrantFiled: December 12, 2005Date of Patent: June 24, 2008Assignee: Seiko Epson CorporationInventors: Kimio Nagasaka, Akira Miyamae, Hiroyasu Kaseya
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Patent number: 7390619Abstract: This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.Type: GrantFiled: November 28, 2000Date of Patent: June 24, 2008Assignee: Maxygen, Inc.Inventors: Juha Punnonen, Willem P. C. Stemmer, Robert Gerald Whalen, Russell J. Howard
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Patent number: 7390620Abstract: This invention relates to a novel method for the identification of obligatory essential nucleic acid sequences, in particular microbial sequences. Further, a method for the identification of novel antimicrobial compounds using the obligatory essential nucleic acids and proteins encoded thereby is provided.Type: GrantFiled: April 8, 2002Date of Patent: June 24, 2008Assignee: Creatogen Laboratories GmbHInventor: Thilo M. Fuchs
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Patent number: 7390621Abstract: A method for determining telomerase activity using primer extension followed with real time PCR quantification is disclosed. The method of the present invention provides a rapid, sensitive and accurate measurement for telomerase activity in a biological sample. In one embodiment, the method includes the steps of: adding the biological sample to a reaction tube containing a first reaction mixture having a first primer and nucleoside triphosphates, a second reaction mixture having a second primer and a DNA polymerase, and a wax layer that separates the first reaction mixture from the second reaction mixture; incubating the biological sample with the first reaction mixture; admixing the extension product with the second reaction mixture; amplifying and quantifying the extension product using real-time PCR and a control template. In another embodiment, the detection method includes an in situ primer extension step that allows the production of the extension product within an intact cell.Type: GrantFiled: November 12, 2003Date of Patent: June 24, 2008Assignee: Allied Biotech, Inc.Inventors: Zhunagwu Li, Jun Bao, Hua Mao, Wenbin Ma, Lina Li
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Patent number: 7390622Abstract: There are disclosed apparatus and methods for the field-assisted acceleration of biological processes involving charged entities, including in particular the detection of target DNA in a biological sample. A reaction cell is provided with a dielectric surface, and a field is generated by inducing charge-separation in the dielectric material by applying a potential to an electrode in contact with the dielectric material.Type: GrantFiled: October 16, 2003Date of Patent: June 24, 2008Assignee: Hai Kang Life Corporation LimitedInventors: Cheung Hoi Yu, Lok Ting Lau, Ka Wai Wong
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Patent number: 7390623Abstract: The present invention relates to 16S-23S rRNA spacer sequences from Staphylococcus aureus and their use in a method for detection and/or identification of Staphylococcus aureus . The invention further relates to a method for detection and identification of Staphylococcus aureus in a sample, involving the steps of: (i) optionally releasing, isolating and/or concentrating the polynucleic acids present in the sample; (ii) optionally amplifying the 16S-23S rRNA spacer region, or a part thereof, with at least one primer pair; (iii) detecting the presence of a 16S-23S rRNA spacer sequence; and (iv) identifying the Staphylococcus aureus present in the sample from the nucleic acid(s) detected in the sample.Type: GrantFiled: July 21, 2004Date of Patent: June 24, 2008Assignee: Innogenetics N.V.Inventors: Geert Jannes, Rudi Rossau, Hugo Van Heuverswyn
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Patent number: 7390624Abstract: The invention concerns a process for the production of metal chelate-labelled peptide antigens, peptides obtainable by this process and their use in an immunological method of detection.Type: GrantFiled: February 10, 2003Date of Patent: June 24, 2008Assignee: Roche Diagnostics GmbHInventors: Christoph Seidel, Ursula-Henrike Wienhues, Eva Höss
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Patent number: 7390625Abstract: The present invention provides a partial peptide comprising the functional domain of a protein comprising an amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NO:2 or SEQ ID NO: 4; a screening method and a kit therefor for a substance which regulates ASK1 activation, or a prophylactic or therapeutic substance for diseases associated with apoptosis or inflammation, which comprises using the protein or the partial peptide or a cell which produces the same, and optionally ASK1 or a partial peptide thereof or a cell which produces the same; and an agent for regulating apoptosis or inflammatory cytokine production, or a prophylactic or therapeutic agent for diseases associated with apoptosis or inflammation, which comprises a substance for regulating an activity of a protein comprising an amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NO:2 or SEQ ID NO: 4.Type: GrantFiled: November 20, 2003Date of Patent: June 24, 2008Assignee: Takeda Pharmaceutical Company LimitedInventor: Hidenori Ichijo
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Patent number: 7390626Abstract: ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different components of Borrelia during different cycles, including peptides from outer surface protein, leukocyte function associated antigens, immunodominant antigens, variable major proteins, and peptides from decorin-binding proteins of Borrelial subspecies (B. sensu stricto. B. afzelii, B. garinii) were used. Antibodies against specific peptides from Babesia and Ehrlichia were also measured.Type: GrantFiled: February 25, 2005Date of Patent: June 24, 2008Assignee: Immunosciences Lab., Inc.Inventor: Aristo Vojdani
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Patent number: 7390627Abstract: Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the assays, and a storage-stable standard (which may be used as a calibrator and/or control) are disclosed. MDA-modified LDL and OxLDL are implicated in atherosclerosis and its etiology.Type: GrantFiled: June 12, 2007Date of Patent: June 24, 2008Assignee: Leuven Research & Development VZWInventors: Paul Noel Holvoet, Désiré José Collen
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Patent number: 7390628Abstract: The present invention concerns novel materials and methods to detect low frequency surface changes utilizing modified microspheres. Upon exposing the surface to the modified microspheres of the subject invention, the microspheres selectively adhere to any targeted surface marker.Type: GrantFiled: December 23, 2004Date of Patent: June 24, 2008Assignee: University of Florida Research Foundation, Inc.Inventor: Christopher D. Batich
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Patent number: 7390629Abstract: Methods of screening and identifying tumor-activated prodrug forms of therapeutic agents are described.Type: GrantFiled: March 8, 2006Date of Patent: June 24, 2008Assignees: La Region Wallonne, Universite Catholique de LouvainInventors: Andre Trouet, Roger Baurain
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Patent number: 7390630Abstract: A method of identifying a compound with efficacy in the treatment of chronic inflammatory disease by testing the compound for an ability to selectively inhibit the ability of Tck cells to induce pro-inflammatory cytokine release from a monocyte is disclosed. The method includes pre-incubatin Tck cells with a compound to be tested, optionally resuspending the Tck cells in the absence of the test compound, co-culturing the Tck cells with monocytes, and assaying for the production of pro-inflammatory cytokines by the monocytes. The Tck cells are produced by incubating a population of T cells with one or more cytokines or the Tck cells are isolated from synovial tissue. The Tck cells have not been contacted with an anti-CD3 antibody. The ability to selectively inhibit cytokine release indicates that the compound has efficacy in the treatment of chronic inflammatory disease.Type: GrantFiled: September 25, 2000Date of Patent: June 24, 2008Assignee: Mathilda and Terence Kennedy Institute of Rheumatology TrustInventors: Fionula Mary Brennan, Marc Feldmann, Brian Maurice John Foxwell
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Patent number: 7390631Abstract: Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d deposited on surfaces of red blood cells in the sample, and optionally also determining complement receptor CR1 deposited on the red blood cell surfaces. For diagnosis this is compared with the quantity of C4d (and optionally CR1) present on red blood cells of normal individuals. For monitoring it is compared with a value in a sample or samples previously obtained from the individual patient. The comparison may be made with individual values for C4d and CR1 and/or with a ratio of the two found in normal individuals.Type: GrantFiled: September 9, 2002Date of Patent: June 24, 2008Assignee: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Joseph M. Ahearn, Susan M. Manzi
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Patent number: 7390632Abstract: The present invention discloses a system and method using the human ErbB3 receptor, p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention also discloses a system and method of p85-sErbB3 binding to heregulin with an affinity comparable to that of full-length ErbB3, and competitively inhibiting high affinity heregulin binding to ErbB2/3 heterodimers on the cell surface of breast carcinoma cells. The present invention also uses p85-sErbB3 to inhibit heregulin-induced phosphorylation of ErbB2, ErbB3, and ErbB4 in cells and uses p85-sErbB3 as a negative regulator of heregulin-stimulated signal transduction and as a block for cell growth. The present invention is also directed to nucleic acids and expression vectors encoding p85-sErbB3, host cells harboring such expression vectors, and methods of preparing the protein.Type: GrantFiled: May 31, 2002Date of Patent: June 24, 2008Assignee: Tumor Biology Investment Group, Inc.Inventors: Nita J. Maihle, Hakjoo Lee
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Patent number: 7390633Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.Type: GrantFiled: April 18, 2006Date of Patent: June 24, 2008Assignee: Massachusetts Institute of TechnologyInventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
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Patent number: 7390634Abstract: ?-netrin nucleic acid molecules and polypeptides are provided. Methods of using the ?-netrin nucleic acid molecules and polypeptides are also provided.Type: GrantFiled: February 28, 2001Date of Patent: June 24, 2008Assignees: The General Hospital Corporation, Tufts UniversityInventors: Pamela Olson, Dale Hunter, William Brunken, Manuel Koch, Robert Burgeson
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Patent number: 7390635Abstract: The present invention provides recombinant peptides that specifically and selectively bind to the human milk fat globule (HMFG) antigen, BA46. In particular, the present invention provides recombinant variants of the Mc3 antibody, including humanized versions of Mc3. The variant Mc3 peptides are particularly useful for diagnostic, prognostic, and therapeutic applications in the field of breast cancer. The present invention also provides methods for the humanization of antibodies such as murine monoclonal antibodies. The novel humanization methods are applied to the production of humanized Mc3 antibodies and it is shown that these humanized antibodies retain the ability to engage in high affinity binding to their cognate antigen. Such humanization enables the use of these antibodies for immunodiagnostic and immunotherapeutic applications in humans.Type: GrantFiled: October 13, 2004Date of Patent: June 24, 2008Assignee: Cancer Research Institute of Contra CostaInventors: Fernando J. R. Do Couto, Robert L. Ceriani, Jerry A. Peterson
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Patent number: 7390636Abstract: Methods and compositions are provided relating to production of recombinant protein in yeast. A modified PLAC4 is described where one or more mutations may be introduced into the Pribnow box-like sequences in the promoter. The modified promoter when placed upstream of a target gene in a vector causes a significant reduction of target gene expression in transformed bacteria but produces efficient expression of the target gene in yeast.Type: GrantFiled: April 8, 2005Date of Patent: June 24, 2008Assignee: New England Biolabs, Inc.Inventors: Christopher Taron, Paul Colussi
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Patent number: 7390637Abstract: The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide, called “KDI”. KDI polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of KDI activity. Also provided are therapeutic methods for treating immune system-related disorders.Type: GrantFiled: September 12, 2002Date of Patent: June 24, 2008Assignee: Human Genome Sciences, Inc.Inventors: David W. LaFleur, Paul A. Moore, Steven M. Ruben
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Patent number: 7390638Abstract: When interferon gamma (IFNG) is produced in mammalian cell lines a heterogenous population of IFNG polypeptides is obtained due to C-terminal processing of the IFNG polypeptide. Clearly, this constitutes a severe problem in that valuable polypeptide material is lost and, further, it is necessary to carry out time-consuming and cumbersome purification in order to obtain a homogenous population of active IFNG polypeptides having the desired length. It has now been found that an IFNG fragment containing 132 amino acid residues (truncated at the nucleotide level by introducing a stop-codon after the codon encoding amino acid residue no. 132) does not undergo C-terminal truncation or, at least, is not significantly C-terminally truncated. Furthermore, as the IFNG fragment containing 132 amino acid residues is active, this opens up the possibility of producing a homogenous active IFNG polypeptide in eukaryotic host cells, such as CHO cells.Type: GrantFiled: April 27, 2005Date of Patent: June 24, 2008Assignee: Maxygen Holdings, Ltd.Inventors: Bart Van Den Hazel, Anne Dam Jensen, Frank Bech Nygaard, Kim Vilbour Andersen
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Patent number: 7390639Abstract: Peptides are produced as fusions with a suitable carrier protein. The carrier protein disclosed herein are adapted from the N-terminal domain of staphylococcus nuclease. This novel carrier protein acts to promote the over-expression of the peptide-protein fusion in the form of inclusion bodies, which minimizes in-cell proteolysis of desired peptides. The fusion protein is readily purified by conventional procedures or His-tag affinity chromatography when His-tag is inserted into the fusion protein. The target peptide is released from the purified fusion protein by a simple cleavage step and separated from the librated carrier protein by use of a reverse-phase HPLC process or by repeating the same affinity purification method. A particular advantage of the disclosed method, in addition to the obvious advantage of high yields, is its use for producing isotopically labeled peptides for NMR characterization of bioactive peptides and their interactions with target proteins.Type: GrantFiled: August 7, 2003Date of Patent: June 24, 2008Assignee: National Research Council of CanadaInventors: Zhengding Su, Feng Ni
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Patent number: 7390640Abstract: Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.Type: GrantFiled: February 22, 2006Date of Patent: June 24, 2008Assignee: Los Alamos National Security, LLCInventors: Geoffrey S. Waldo, Stephanie Cabantous
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Patent number: 7390641Abstract: A process for the production of peroxidase which comprises of establishing a plant cell culture producing cells from neem (Azardiracta indica) and nirgundi (Vitex negundo) wherein the peroxidase has higher enzymatic activity not reported earlier.Type: GrantFiled: May 24, 2005Date of Patent: June 24, 2008Assignee: Council of Scientific and Industrial ResearchInventors: Tholath Emilia Abraham, Nisha Rani Devaki, Thomson Kuruvilla, Jegan Roy Joseph
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Patent number: 7390642Abstract: This invention provides: (A) a protein the sequence of which is in FIG. 8 (SEQ. ID n° 14), or a fragment thereof having at least 15 amino acids, or a variant thereof, having at least 70% identity with FIG. 8 (SEQ. ID n° 14) over a length of at least 400 amino acids; (B) a peptide comprising a fragment of salutaridinol 7-O-acetyltransferase of at least 6 consecutive amino acids not present in other plant acetyltransferases as in FIG. 2 (SEQ. IDs n° 8 to 12); (C) a nucleic acid (i) the sequence of which is in FIG. 9 (SEQ. ID n° 13) or FIG. 10 (SEQ. ID n° 15), or (ii) a fragment thereof of at least 45 nucleotides, or (iii) a variant thereof, having at least 70% identity with FIG. 9 (SEQ. ID n° 13) or FIG. 10 (SEQ.Type: GrantFiled: June 11, 2002Date of Patent: June 24, 2008Assignee: Donald Danforth Plant Science CenterInventors: Toni M. Kutchan, Meinhart H. Zenk, Torsten Grothe
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Patent number: 7390643Abstract: In one aspect, the present invention provides isolated nucleic acid molecules that each encode a geranyl diphosphate synthase protein, wherein each isolated nucleic acid molecule hybridizes to a nucleic acid molecule consisting of the sequence set forth in SEQ ID NO:1 under conditions of 5×SSC at 45° C. for one hour. The present invention also provides isolated geranyl diphosphate synthase proteins, and methods for altering the level of expression of geranyl diphosphate synthase protein in a host cell.Type: GrantFiled: January 31, 2005Date of Patent: June 24, 2008Assignee: Washington State University Research FoundationInventors: Rodney Bruce Croteau, Charles Cullen Burke
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Patent number: 7390644Abstract: The present invention is directed to a Sphingomonas bacteria and a method of producing exopolysaccharides by culturing a Shpingomonas bacteria in a fermentation broth for a time and temperature effective for providing a sphingan exopolysaccharide in a slime form.Type: GrantFiled: July 10, 2003Date of Patent: June 24, 2008Assignees: Shin-Etsu Bio., Inc., Shin-Etsu Chemical Company, Ltd.Inventors: Motohide Yamazaki, Marcia Mikolajczak, Thomas J. Pollock, Richard W. Armentrout
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Patent number: 7390645Abstract: The present invention provides altered lac repressor proteins that recognize the lactose operator with increased affinity and have either normal or enhanced ligand responsivity. For example, the lac repressor Gln60Gly mutant protein exhibits increased binding affinity for lactose operator DNA, while maintaining near-normal responsivity to IPTG. Alternatively, the present invention provides modified repressors which exhibit responsiveness to an alternative ligand, such as arabinose, or have enhanced responsivity to IPTG. For example, Gln60Gly/Leu148Phe binds with wild-type affinity to lactose operator DNA and exhibits enhanced responsivity to IPTG. The present invention also provides for repressors that exhibit both characteristics: increased affinity for lactose operator and enhanced ligand responsivity. Enhanced ligand response enables induction of gene expression to be finely controlled by a researcher.Type: GrantFiled: July 17, 2002Date of Patent: June 24, 2008Assignee: William Marsh Rice UniversityInventors: Kathleen S. Matthews, Catherine M. Foster, Liskin Swint-Kruse
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Patent number: 7390646Abstract: The present invention provides a live, attenuated, invasive bacterium that infects a mammalian host cell, and releases exogenous RNA into the cytoplasm of the host cell. The present invention further provides compositions, including immunogenic compositions, comprising a subject bacterium. The present invention provides methods of delivering an RNA to a eukaryotic host cell in vitro, ex vivo, or in vivo. The present invention provides methods of delivering a protein to a host cell in vitro, ex vivo, or in vivo. The present invention provides methods of controlling expression of a target gene in a eukaryotic host cell. The present invention provides methods of inducing an immune response in a mammalian host to a polypeptide antigen, the method involving administering to the host a subject bacterium, wherein the antigen is encoded by the exogenous RNA produced by the bacterium.Type: GrantFiled: September 17, 2004Date of Patent: June 24, 2008Assignee: The Regents of the University of CaliforniaInventors: Raul Andino-Pavlovsky, Marco Vignuzzi, Derek H. Wells
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Patent number: 7390647Abstract: The invention relates to a method for producing chiral ?-hydroxycarboxylic crystalline acids consisting in transforming cyanhydrins (R) or (S) into ?-hydroxycarboxylic acids (R) or (S), respectively by enzymatic hydrolysis in the presence of Rhodococcus erythropolis NCIMB 11540.Type: GrantFiled: January 30, 2004Date of Patent: June 24, 2008Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KGInventors: Herfried Griengl, Ingrid Osprian, Hans Schoemaker, Christoph Reisinger, Helmut Schwab
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Patent number: 7390648Abstract: The present invention relates generally to microelectromechanical systems (MEMS) devices for the manipulation of cells or groups of cells, such as oocytes, embryos, and sperm. In particular, the present invention relates to Cell Labeling MEMS devices (2F), Microinjection MEMS devices, IntraCytoplasmic Sperm Injection (“ICSI”) MEMS devices, Zona Coring MEMS devices, Enucleation MEMS devices, Enucleation/Nuclear Transfer MEMS devices, and Cytoplasmic Transfer MEMS devices. The present invention also relates to kits containing the MEMS devices of the present invention.Type: GrantFiled: April 24, 2000Date of Patent: June 24, 2008Inventor: Monica Palacios-Boyce
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Patent number: 7390649Abstract: The invention relates to sensor chips with multiple layers of polysiloxane with improve homogeneity.Type: GrantFiled: July 24, 2001Date of Patent: June 24, 2008Assignee: Micronas Holding GmbHInventors: Holger Klapproth, Jürgen Rühe, Sonia Mohry
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Patent number: 7390650Abstract: The invention provides a system, system components, and a method for rapidly obtaining and stably maintaining a cell in optimal contact with the cell-contacting surface of a sensor in a cell-based biosensor. In one aspect, the system maximizes the seal between a whole cell and the cell-contact surface of a patch clamp micropipette, maximizing the efficiency of a whole cell patch clamp recording.Type: GrantFiled: August 20, 2003Date of Patent: June 24, 2008Assignee: Cellectricon ABInventors: Mattias Karlsson, Owe Orwar, Daniel T. Chiu, Jon Sinclair, Kent Jardemark, Jessica Olofsson, Johan Pihl, Cecilia Farre
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Patent number: 7390651Abstract: A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from which it is derived. Methods using the cells of the serum-free C3A clonal cell line for the production, expression and recovery of harvestable polypeptides, screening compounds for metabolic activity, studying enteric disease and for use in a bio-artificial liver device are also provided.Type: GrantFiled: November 25, 2003Date of Patent: June 24, 2008Assignee: Vital Therapies, Inc.Inventors: Dennis Triglia, Anthony Purchio
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Patent number: 7390652Abstract: This invention relates to methods for the cultivating cells, and in particular to methods for propagating viruses.Type: GrantFiled: August 16, 2004Date of Patent: June 24, 2008Assignee: Schering CorporationInventors: Russell G. G. Condon, Nancy V. Connelly, Andreas Frei, Edward Glowacki, Vijay Yabannavar, Serge Batandolo
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Patent number: 7390653Abstract: The culture chamber of the present invention has a fluid-filled culture compartment in which cells, tissues and other biologicals are cultured. The culture compartment is transversed by one or more molecular weight cut-off membranes attached to a membrane carrier assembly. Incoming nutrients are transported through the membrane into the culture compartment and metabolic waste products are transported away from the fluid-filled culture compartment through the membrane and out the chamber outlet. Both reusable and disposable culture chambers are described for culturing cells, cell aggregates, particles, tissues and organoids.Type: GrantFiled: December 2, 2003Date of Patent: June 24, 2008Assignee: Synthecon, Inc.Inventors: Roger Akers, William J. Anderson, Adrian F. Dinges, Jr., Stephen S. Navran, Jr.
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Patent number: 7390654Abstract: Disclosed herein are improved plasmid shuttle vectors, vaccines based on them, and methods related to their construction and use. Particular arrangements of functional elements of such plasmids, namely origins of replication and eukaryotic transcription/translation control elements, which give rise to generally undesirable side-products upon propagation of the plasmids in bacterial culture are disclosed. These side-products apparently arise as terminated replication intermediates. Strategies both to eliminate accumulation of these side-products, and to make them useful as a vaccine adjuvant, are described.Type: GrantFiled: May 13, 2003Date of Patent: June 24, 2008Assignee: MannKind CorporationInventor: John Levy
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Patent number: 7390655Abstract: The present invention provides DNA molecules isolated from corn and sorghum plants that are useful for expressing transgenes in plants. The present invention also provides expression constructs containing the DNA molecules useful for expressing transgenes in plants. The present invention also provides transgenic plants and seeds containing the DNA molecules useful for expressing transgenes in plants.Type: GrantFiled: March 21, 2006Date of Patent: June 24, 2008Assignee: Monsanto Technology LLCInventor: Brendan Hinchey