Patents Issued in June 24, 2008
  • Patent number: 7390756
    Abstract: A dielectric layer containing an atomic layer deposited zirconium silicon oxide film disposed in an integrated circuit and a method of fabricating such a dielectric layer provide a dielectric layer for use in a variety of electronic devices. Embodiments include forming zirconium silicates as dielectric layers in devices in an integrated circuit. In an embodiment, a zirconium silicon oxide film is formed by atomic layer deposition using a zirconium precursor containing silicon and a silicon precursor. Embodiments include structures for capacitors, transistors, memory devices, and electronic systems with dielectric layers containing an atomic layer deposited zirconium silicon oxide film, and methods for forming such structures.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: June 24, 2008
    Assignee: Micron Technology, Inc.
    Inventors: Kie Y. Ahn, Leonard Forbes
  • Patent number: 7390757
    Abstract: The present invention relates to fluorinated silicate glass (FSG) with low dielectric constant and improved gap-fill characteristics. In the present method, a fluorinated silicon source, an optional fluorine source, an optional carbon source, a hydrogen source, and an oxygenator are used as the reactant gases. Inert or carrier gas(es) may also be used. In accordance with the present invention, the reactant gas mixture does not comprise a silane compound having the general formula SixHy, wherein x has a range of 1 to 2, y has a range of 4 to 6. The material deposited is thus referred to herein alternatively as “SixFy-only FSG” or “SixFy-only fluorinated oxide” (“SOFO”).
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: June 24, 2008
    Assignee: Applied Materials, Inc.
    Inventors: Seong-Oh Woo, Jun Tae Choi
  • Patent number: 7390758
    Abstract: A sealed type container accommodating a semiconductor substrate is positioned to a load port of a semiconductor manufacturing apparatus. The semiconductor substrate is taken out of the container. An ionizer is used for static-eliminating the semiconductor substrates before and after process treatment in a transport area between the load port and a treatment section. The static-eliminated semiconductor substrate is accommodated in the container positioned to the load port. Thus, it is possible to decrease foreign materials adhering to the semiconductor substrate and errors in handling the semiconductor substrate.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: June 24, 2008
    Assignee: Renesas Technology Corp.
    Inventor: Yoshiaki Kobayashi
  • Patent number: 7390759
    Abstract: The invention provides a steel plate reinforcing sheet having light weight and thin layer, providing sufficient adhesion and reinforcing effect to a steel plate, and having excellent workability. In the steel plate reinforcing sheet comprising a restricting layer and a resin layer, a curing composition is first prepared by mixing rubber components comprising diene-based rubber and rubber having a vinyl group in its side chain, with a cross-linking agent capable of reacting with these rubber components, and then by kneading the mixture. Thereafter, the curing composition thus prepared is rolled by molding, to form a resin layer. Then, the resin layer thus formed is adhesively bonded to the restricting layer, to produce a steel plate reinforcing sheet.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: June 24, 2008
    Assignee: Nitto Denko Corporation
    Inventors: Yasuhiko Kawaguchi, Katsuhiko Tachibana
  • Patent number: 7390760
    Abstract: A composite material comprising a plurality of nanofibers intertwined with a plurality of coarse fibers to form one or more layers is provided. The nanofibers can be any suitable type of nanofiber, including electrospun fibers. A composite material comprising a plurality of electrospun fibers intertwined with a plurality of coarse fibers to form a single layer is also provided. A composite material comprising a plurality of electrospun fibers combined with a plurality of coarse fibers to form a plurality of layers, i.e., a multi-layer material, is also provided. In some embodiments, gradients in one or more directions are produced. Embodiments of the invention also provide processes for producing the composite nanofiber material. The materials are useful for any type of disposable garment, wipe, hospital garment, face mask, sterile wrap, air filter, water filter and so forth. Materials described herein can provide strong and varying surface effects, such as wicking.
    Type: Grant
    Filed: November 2, 2004
    Date of Patent: June 24, 2008
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Fung-jou Chen, Lei Huang, Jeffrey D. Lindsay
  • Patent number: 7390761
    Abstract: The invention relates to an alkaline-earth aluminosilicate glass with the following composition (in wt. %, based on oxide content): SiO2 >58-62; B2O3 0 5.5; Al2O3 13.5 17.5; MgO 0-7; CaO 5.5-14; SrO 0-8, BaO 6-14; ZrO2 0-2; CeO2 0.001 0.5; TiO2 0.01-2. The glass is particularly suitable for use as a bulb material for halogen light bulbs.
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: June 24, 2008
    Assignee: Schott AG
    Inventors: Joery Hinrich Fechner, Peter Brix, Franz Ott
  • Patent number: 7390762
    Abstract: A method for synthesizing high-content NaY molecular sieves with kaolin sprayed microspheres includes adding functional components and deionized water into kaolin so as to be pulped into a mixed slurry. The slurry is sprayed into microspheres. The microspheres are calcined at a temperature between 700 and 1,000° C. and mixed with a directing agent for crystallization. The resultant solid is filtrated and washed with water and then dried to obtain a final in-situ crystallized product with high content of molecular sieves.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: June 24, 2008
    Assignee: PetroChina Company Limited
    Inventors: Xionghou Gao, Honghai Liu, Baojie Wang, Changyan Duan, Xinmei Pang, Li Zhang, Lianhong Zhao, Jiangang Ma, Yunheng Liu
  • Patent number: 7390763
    Abstract: The invention is directed to a method of making a small crystal SSZ-32 zeolite, known as SSZ-32X. The catalyst is suitable for use in a process whereby a feed including straight chain and slightly branched paraffins having 10 or more carbon atoms is dewaxed to produce an isomerized product, with increased yield of isomerized material and decreased production of light ends.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: June 24, 2008
    Assignee: Chevron U.S.A. Inc.
    Inventors: Stacey I. Zones, Guang Zhang, Kamala R. Krishna, Joseph A. Biscardi, Paul Marcantonio, Euthimios Vittoratos
  • Patent number: 7390764
    Abstract: This invention provides catalyst compositions that are useful for polymerizing at least one monomer to produce a polymer This invention also provides catalyst compositions that are useful for polymerizing at least one monomer to produce a polymer, wherein said catalyst composition comprises a post-contacted organometal compound, a post-contacted organoaluminum compound, and a post-contacted fluorided silica-alumina.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: June 24, 2008
    Assignee: Phillips Petroleum Company
    Inventors: Max P. McDaniel, Elizabeth A. Benham, Michael D. Jensen, Joel L. Martin, Gil R. Hawley
  • Patent number: 7390765
    Abstract: Low-cure powder coating compositions are disclosed. The compositions comprise a polyepoxide and a material having the structure wherein R1 is an organic radical having 6 to 25 carbon atoms; R2 is an organic radical having 1 to 20 carbon atoms; R3 and R4 are independently alkyl or phenyl groups having 1 to 8 carbon atoms; Z is oxygen or nitrogen, and when Z is oxygen R5 is absent and when Z is nitrogen R5 is hydrogen or is and n is 1 to 4. The material can optionally be reacted with an acidic hydrogen-containing compound. The compositions are curable without the use of crosslinking agents or accelerators. Methods for coating a substrate using these compositions, and substrates coated thereby, are also disclosed, as are additional catalysts useful for the same purpose.
    Type: Grant
    Filed: June 5, 2007
    Date of Patent: June 24, 2008
    Assignee: PPG Industries Ohio, Inc.
    Inventors: Anthony M. Chasser, Shawn P. Duffy, Ronald R. Ambrose
  • Patent number: 7390766
    Abstract: Stable catalyst carrier impregnating solutions can be prepared using a component of a Group VIB metal, e.g., molybdenum, at high concentration, a component of a Group VIII metal, e.g., nickel, at low concentration, and a phosphorous component, e.g., phosphoric acid, at low concentration, provided that the Group VIII metal is in a substantially water-insoluble form and a particular sequence of addition of the components is followed, even when a substantially water-insoluble form of the Group VIB component is used. The resulting stabilized impregnating solution can be supplemented with additional Group VIII metal in water-soluble form to achieve increased levels of such metal in the final catalyst. Furthermore, uncalcined catalyst carriers impregnated with the stable solution and subsequently shaped, dried and calcined, have unexpectedly improved performance when used in the hydroprocessing of heavy hydrocarbon feedstocks.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: June 24, 2008
    Inventor: Darryl P. Klein
  • Patent number: 7390767
    Abstract: This invention relates generally to a method for producing fullerene nanotube catalyst supports and compositions thereof. In one embodiment, fullerene nanotubes or fullerene nanotube structures can be employed as the support material. A transition metal catalyst is added to the fullerene nanotubes. In a preferred embodiment, the catalyst metal cluster is deposited on the open nanotube end by a docking process that insures optimum location for the subsequent growth reaction. The metal atoms may be subjected to reductive conditions.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: June 24, 2008
    Assignee: William Marsh Rice University
    Inventors: Richard E. Smalley, Daniel T. Colbert, Hongjie Dai, Jie Liu, Andrew G. Rinzler, Jason H. Hafner, Ken Smith, Ting Guo, Pavel Nikolaev, Andreas Thess
  • Patent number: 7390768
    Abstract: The invention described herein involves a novel approach to the production of oxidation/reduction catalytic systems. The present invention serves to stabilize the tin oxide reducible metal-oxide coating by co-incorporating at least another metal-oxide species, such as zirconium. In one embodiment, a third metal-oxide species is incorporated, selected from the group consisting of cerium, lanthanum, hafnium, and ruthenium. The incorporation of the additional metal oxide components serves to stabilize the active tin-oxide layer in the catalytic process during high-temperature operation in a reducing environment (e.g., automobile exhaust). Moreover, the additional metal oxides are active components due to their oxygen-retention capabilities. Together, these features provide a mechanism to extend the range of operation of the tin-oxide-based catalyst system for automotive applications, while maintaining the existing advantages.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: June 24, 2008
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Jeffrey D. Jordan, David R. Schryer, Patricia P. Davis, Bradley D. Leighty, Anthony Neal Watkins, Jacqueline L. Schryer, Donald M. Oglesby, Suresh T. Gulati, Jerry C. Summers
  • Patent number: 7390770
    Abstract: A catalyst for purifying an exhaust gas containing carbon monoxide and volatile organic compounds, which has a coat layer of a carrier composed of a porous inorganic compound, wherein the coat layer is a single layer, the porous inorganic compound has a BET specific surface area of 50 m2/g or greater, and the coat layer has, within a 50 ?m depth from the surface thereof, an active metal having a particle size of 15 nm or less and composed of at least one noble metal.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: June 24, 2008
    Assignee: Mitsubishi Heavy Industries, Ltd.
    Inventors: Katsumi Nochi, Masanao Yonemura, Yoshiaki Obayashi, Toshiyuki Onishi
  • Patent number: 7390771
    Abstract: The present invention provides a composition and a recording material made from the composition having an excellent dynamic sensitivity in recording as well as an excellent image stability and, particularly, having excellent resistance for heat and humidity, heat, light, plasticizer and water. The composition and the recording material include the following compounds (1), (2), and (3): wherein R1, R2, R6, R7, R11, and R12 each represents hydrogen or an alkyl group; a1 to a3 each represents an integer of 1-6; n1 to n3 each represents 0, 1 or 2; m1, m4 and m7 each represents 0, 1, 2 or 3; R3, R4, R8, R9, R13 and R14 each represents an alkyl group; m2, m3, m5, m6, m8 and m9 each represents 0, 1 or 2; and Y1 to Y3 each represents CO or NRCO (R represents hydrogen, etc.).
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: June 24, 2008
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Tadashi Kawakami, Shinichi Sato, Hiroshi Fujii
  • Patent number: 7390772
    Abstract: The present invention is directed to novel compounds of the general formula wherein R and R1 independently represent a hydrogen or a straight, branched or cyclic hydrocarbon moiety consisting of less than 15, preferably less than 10, most preferably less than 4 carbon atoms and containing single and/or double bonds. Another embodiment of the invention is a method for enhancing a perfume composition by incorporating an olfactory acceptable amount of the compound provided above.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: June 24, 2008
    Assignee: International Flavor & Fragrances Inc.
    Inventors: Anubhav P. S. Narula, Edward Mark Arruda, Patrick M. Merritt, Franc T. Schiet
  • Patent number: 7390773
    Abstract: An aqueous tire wheel cleaner composition useful for cleaning automobile tires are provided. The aqueous tire wheel cleaner composition contains an alkylene glycol, a salt of dialkyl sulfosuccinate, and as surfactants ethanol amine and an ethoxylate phosphate ester.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: June 24, 2008
    Assignee: Shell Oil Company
    Inventor: Liliana Minevski
  • Patent number: 7390774
    Abstract: Antimicrobial compositions and methods of making and using the same are disclosed. The disclosed antimicrobial compositions provide persistent, broad spectrum, antimicrobial activity. The antimicrobial compositions may be used in the preparation of antimicrobial articles. The antimicrobial compositions may also be used to inhibit the growth of microorganisms by introducing those compositions onto or into an environment subject to microbial attack.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: June 24, 2008
    Assignee: Rohm and Haas Company
    Inventors: Tirthankar Ghosh, Barry Weinstein
  • Patent number: 7390775
    Abstract: Surfactant-thickened active chlorine-containing bleach compositions including at least one water soluble anionic styrenic polymer are described. The styrenic polymer serves to improve the rheology properties of the thickened bleach composition. The thickened bleach composition additionally includes a surfactant-based thickening system including an amine oxide, and an alkaline agent to maintain the pH of the composition at about 10 or greater. The amine oxide includes at least 75% of one or more C14-C18 alkyl dimethyl amine oxides. The thickened bleach compositions have reduced viscosity, decreased elastic properties, with improved flow and pour properties resulting from the inclusion of the styrenic polymer.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: June 24, 2008
    Assignee: S.C. Johnson & Son, Inc.
    Inventors: Wayne M. Rees, Susan L. Bryant
  • Patent number: 7390776
    Abstract: A liquid detergent builder which is highly compatible with a surfactant and gives transparent liquid detergents having extremely excellent detergency, a liquid detergent containing the builder, and a liquid detergent containing an acrylic acid-based polymer (salt) having excellent clay dispersibility and good compatibility with a surfactant. The liquid detergent builder comprises an acrylic acid/maleic acid-based copolymer (salt), wherein the acrylic acid/maleic acid-based copolymer (salt) contains maleic acid (salt) in an amount of 5-90 mol % per mole of the sum of acrylic acid (salt) and maleic acid (salt), and a product (MA×Mw) of a weight average molecular weight (Mw) of the copolymer (salt) and a proportion (MA (mol %)) of the maleic acid (salt) in the copolymer (salt) is 450,000 or less.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: June 24, 2008
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Takahiro Tsumori, Atsuro Yoneda, Akiko Hemmi, Shigeru Yamaguchi
  • Patent number: 7390777
    Abstract: Describes compositions of 1,2-dichloroethylene, particularly trans-1,2-dichloroethylene, stabilized with effective stabilizing amounts of a combination of (a) C3 to C12 alkylene oxide, e.g., butylene oxide, (b) alcohol chosen from aliphatic and cycloaliphatic alcohols having from 2 to 8 carbon atoms, e.g., isopropanol, and (c) a material chosen from (i) C1 to C5 alkoxyphenol, e.g., 4-methoxyphenol, (ii) free radical stabilizer having at least one 2,2,6,6-tetra(lower alkyl)-1-piperidinyloxy-yl group, and (iii) mixtures of (i) and (ii). Also describes use of such compositions for vapor degreasing of soiled articles, e.g., metal parts and soldered circuit boards.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: June 24, 2008
    Assignee: PPG Industries Ohio, Inc.
    Inventors: Michael P. Dobrasko, Ronald D. Olinger
  • Patent number: 7390778
    Abstract: A composition for treating fabrics, comprising: a) a fabric shrinkage reducing composition selected from the group consisting of ethylene glycol, all isomers of propanediol, butanediol, pentanediol, hexanediol and mixtures thereof; b) a liquid cleaning/refreshment composition. The fabric shrinkage reducing composition and the liquid cleaning/refreshment composition are releasably absorbed in a substrate in a weight ratio of from about 1:2 to about 1:5. The fabric shrinkage reducing composition helps to reduce shrinkage of the fabrics treated in an in-home, non-immersion cleaning and refreshing process which is conducted in a clothes dryer, or the like apparatus. Also provided are non-immersion cleaning/refreshment processes using this composition, a kit containing the necessary items to conduct the processes of this invention and a sheet for releasably absorbing the compositions of this invention.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: June 24, 2008
    Assignee: The Procter & Gamble Company
    Inventors: Janine Morgens Strang, Michael Peter Siklosi
  • Patent number: 7390779
    Abstract: Odourant compounds selected from compounds having the structure: wherein, R1 and R2 may be independently hydrogen or methyl, and n is an integer 1, 2 or 3 provided that n+ the carbon atoms in R1 and R2 is less than 5, their preparation and their use in fine fragrances and perfume components, wherein the compounds provide a musk characteristic.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: June 24, 2008
    Assignee: Givaudan SA
    Inventors: Philip Kraft, Riccardo Cadalbert
  • Patent number: 7390780
    Abstract: A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a hydrophilic polymer by a releasable linkage. The liposomes are associated with a nucleic acid for delivery to a cell.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: June 24, 2008
    Assignee: Alza Corporation
    Inventors: Shi-Kun Huang, Samuel Zalipsky
  • Patent number: 7390781
    Abstract: Disclosed are novel proteins, referred to as truncated glial cell line-derived neurotrophic factor (truncated GDNF) proteins, that promote dopamine uptake by dopaminergic cells and promote the survival of nerve cells. Also disclosed are processes for obtaining the truncated GDNF proteins by recombinant genetic engineering techniques.
    Type: Grant
    Filed: January 7, 2004
    Date of Patent: June 24, 2008
    Assignee: Amgen Inc.
    Inventor: Shaw-Fen Sylvia Hu
  • Patent number: 7390782
    Abstract: The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The invention also involves related compositions and screening assays.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: June 24, 2008
    Assignee: University of Vermont and State Agricultural College
    Inventor: Martha Karen Newell
  • Patent number: 7390783
    Abstract: The invention provides a pharmaceutical composition comprising a synthetic or naturally occurring charged phospholipid, which is formulated into a dosage form for administration to a subject or which is administered as a food additive. Negatively charged phospholipid composition increase the net negative charge on intravascular lipoproteins, enhance the clearance of cholesterol and regulate the function of lipolytic enzymes, retard prothrombin formation and aid in the clearance of virus and bacterial particles. Negatively charged lipid compositions can therefore be administered to humans and animals for the treatment of hyperlipidemia and blood coagulation disorders and to reduce the levels of virus, bacteria, and endotoxins in the blood stream. Positively charged lipid compositions can be administered to delay lipoprotein clearance from the plasma compartment and give longer duration of activity for drugs which are associated with lipoproteins.
    Type: Grant
    Filed: October 4, 2004
    Date of Patent: June 24, 2008
    Assignees: Ottawa Heart Institute Research Corporation, Liponex Inc.
    Inventor: Daniel L. Sparks
  • Patent number: 7390784
    Abstract: Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. In the subject methods, an effective amount of the bifunctional molecule is administered to the host. The bifunctional molecule binds to the presenter protein to produce a binary complex that exhibits at least one of improved affinity, specificity or selectivity as compared to the corresponding free drug. The subject methods and compositions find use in a variety of therapeutic applications.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: June 24, 2008
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Roger Briesewitz, Gerald R. Crabtree, Thomas Wandless, Gregory Thomas Ray, Kurt W. Vogel
  • Patent number: 7390785
    Abstract: The invention relates to relatively short peptides (termed ?-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: June 24, 2008
    Assignees: The University of Utah Research Foundation, Cognetix, Inc.
    Inventors: Craig Walker, Reshma Shetty, Baldomero M. Olivera, David Hooper, Richard Jacobsen, Doug Steel, Robert Jones
  • Patent number: 7390786
    Abstract: Protein formulations and methods for reducing the viscosity of a protein formulation are provided. The method for reducing the viscosity of a protein formulation comprises adding a viscosity reducing agent, such as calcium chloride or magnesium chloride to the protein formulation.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: June 24, 2008
    Assignee: Wyeth
    Inventors: Nicholas W. Warne, Pilarin Elizabeth Louise Nichols, Paulo Jorge Loureiro
  • Patent number: 7390787
    Abstract: Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: June 24, 2008
    Assignee: Migenix Inc.
    Inventors: Janet R. Fraser, Michael H. P. West, Timothy J. Krieger, Robert Taylor, Douglas Erfle
  • Patent number: 7390788
    Abstract: The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example insulin and Peptide T or analog thereof.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: June 24, 2008
    Inventors: Candace B. Pert, Michael R. Ruff
  • Patent number: 7390789
    Abstract: The present invention is directed to an ? thio-containing compound that is capable of inhibiting the enzyme, membrane aminopeptidase P (mAPP or APP), whose natural substrate is bradykinin. The compound is useful as a pharmaceutical agent because by inhibiting bradykinin degradation, the compound allows bradykinin to exert its beneficial effects on the cardiovascular system, to improve renal function, and to improve glucose tolerance and insulin-sensitivity. The present invention is also directed to a pharmaceutical composition comprising the mAPP inhibitor of the present invention and a pharmaceutically acceptable carrier. In another aspect, the present invention is directed to a method of inhibiting bradykinin degradation in a mammalian patient, preferably human, in need of treatment comprising administering to the patient a therapeutically effective amount of an ? thio-containing compound of the present invention.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: June 24, 2008
    Inventor: William H Simmons
  • Patent number: 7390790
    Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: June 24, 2008
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
  • Patent number: 7390791
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: June 24, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
  • Patent number: 7390792
    Abstract: Delta protein expression in a cell is reduced by introducing miR-1 into the cell, and detecting a resultant reduction of Delta protein expression in the cell.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: June 24, 2008
    Assignee: Board of Regents, The University of Texas System
    Inventors: Deepak Srivastava, Chulan Kwon
  • Patent number: 7390793
    Abstract: The present invention provides micelles, solutions comprising micelles, methods for preparing micelles, and methods for delivering micelles to patients. The micelles have fixed, preselected hydrodynamic diameters and are formed from basic or acidic amphiphilic compounds.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: June 24, 2008
    Assignee: Eisai Co., Ltd.
    Inventors: James McShane, Tori Arens, Kazuhiro Kaneko, Tomohiro Watanabe, Kazuhide Ashizawa
  • Patent number: 7390795
    Abstract: A method for the treatment or prevention of tissue damage in a subject having an inflammatory and/or tissue damaging condition, which comprises administering to the subject an effective amount of a compound capable of inhibiting the binding of C-reactive protein (CRP) to an autologous or extrinsic ligand.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: June 24, 2008
    Assignee: Pentraxin Therapeutics Limited
    Inventor: Mark B. Pepys
  • Patent number: 7390796
    Abstract: Compounds are disclosed of the formula in which R3 is C8 to C24 hydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: June 24, 2008
    Assignee: Sepracor Inc.
    Inventors: Mark G. Currie, Steven Jones, Charles M. Zepp
  • Patent number: 7390797
    Abstract: The present invention provides a novel fused indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein Z11 and Z12 each independently represent a carbonyl group, a methylene group, etc.; represents a double bond or a single bond; R1a represents a hydrogen atom, etc.; the ring A represents a benzene ring, a naphthalene ring or a 5- to 10-membered aromatic heterocyclic ring, etc.; and R2a, R2b and R2c each independently represent (1) a hydrogen atom, (2) a halogen atom, (3) a nitro group, etc.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: June 24, 2008
    Assignee: Eisai Co., Ltd.
    Inventors: Norihito Ohi, Nobuaki Sato, Naohiro Kohmura
  • Patent number: 7390798
    Abstract: The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache.
    Type: Grant
    Filed: February 9, 2005
    Date of Patent: June 24, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Theresa M. Williams, Christopher S. Burgey, Thomas J. Tucker, Craig A. Stump, Ian M. Bell
  • Patent number: 7390799
    Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: June 24, 2008
    Assignee: Abbott Laboratories
    Inventors: Milan Bruncko, Hong Ding, Steven W. Elmore, Aaron R. Kunzer, Christopher L. Lynch, William J. McClellan, Cheol Min Park, Xiahong Song, Xilu Wang
  • Patent number: 7390800
    Abstract: The present invention relates to an adenosine deaminase inhibitor and a novel Bacillus sp. strain which produces it. Particularly, the present 5 invention relates to the adenosine deaminase inhibitor, and the novel Bacillus sp. IADA-7 producing the above adenosine deaminase inhibitor. The adenosine deaminase inhibitor of the present Invention shows superior antibacterial and anticancer activities to the previously reported adenosine deaminase inhibitors.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: June 24, 2008
    Assignee: FCB-Pharmicell Co., Ltd.
    Inventors: Gwang Lee, Young Hwan Ahn, Ki Ho Park, Hong Ki Jun
  • Patent number: 7390801
    Abstract: Disclosed are compounds which inhibit ?-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ?-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: June 24, 2008
    Assignees: Athena Neurosciences, Inc., Eli Lilly and Company
    Inventors: Eugene D. Thorsett, Michael A. Pleiss, Lee H. Latimer, Varghese John, Stephen Freedman, Thomas C. Britton, James A. Audia, Jon K. Reel, Bruce A. Dressman, James J. Droste, Steven S. Henry, Russell D. Stucky, Warren J. Porter
  • Patent number: 7390802
    Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: June 24, 2008
    Assignee: Bristol-Myers Squibb Pharma Corporation
    Inventors: Qi Han, Hong Liu, Richard E. Olson, Michael G. Yang
  • Patent number: 7390803
    Abstract: The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: June 24, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Gabor Butora, Sander G. Mills, Alexander Pasternak, Kothandaraman Shankaran, Lihu Yang, Changyou Zhou, Stephen D. Goble
  • Patent number: 7390804
    Abstract: An N-containing five-membered ring compound of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of inflammatory diseases, diseases induced by apoptosis, diseases induced by disorders of immune responses, autoimmune diseases, diseases induced by decomposition of proteins which compose organism, shock, circulatory system disorders, blood coagulation systems disorders, malignant tumors, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitic diseases, nerve degeneration diseases, pulmonary disorders, bone resorption diseases, endocrinesthenia, etc.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: June 24, 2008
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Kazuyuki Ohmoto, Iori Itagaki
  • Patent number: 7390805
    Abstract: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: June 24, 2008
    Assignee: Novartis AG
    Inventors: Guido Bold, Hans-Georg Capraro, Giorgio Caravatti, Peter Traxler
  • Patent number: 7390806
    Abstract: The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: June 24, 2008
    Assignee: Anacor Pharmaceuticals, Inc.
    Inventors: Ving Lee, Stephen J. Benkovic, Stephen J. Baker, Kirk R. Maples, Tsutomu Akama, Yong-Kang Zhang, Rajeshwar Singh, Vittorio A. Sauro, Chetan Pandit, Zhuoyi Su, Zhixiang Yang
  • Patent number: 7390807
    Abstract: The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes for preparing the new crystal forms of lamotrigine.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: June 24, 2008
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Nissim Garti, Yana Berkovich, Ben-Zion Dolitzky, Judith Aronhime, Claude Singer, Anita Liebermann, Neomi Gershon