Patents Issued in June 24, 2008
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Patent number: 7390756Abstract: A dielectric layer containing an atomic layer deposited zirconium silicon oxide film disposed in an integrated circuit and a method of fabricating such a dielectric layer provide a dielectric layer for use in a variety of electronic devices. Embodiments include forming zirconium silicates as dielectric layers in devices in an integrated circuit. In an embodiment, a zirconium silicon oxide film is formed by atomic layer deposition using a zirconium precursor containing silicon and a silicon precursor. Embodiments include structures for capacitors, transistors, memory devices, and electronic systems with dielectric layers containing an atomic layer deposited zirconium silicon oxide film, and methods for forming such structures.Type: GrantFiled: April 28, 2005Date of Patent: June 24, 2008Assignee: Micron Technology, Inc.Inventors: Kie Y. Ahn, Leonard Forbes
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Patent number: 7390757Abstract: The present invention relates to fluorinated silicate glass (FSG) with low dielectric constant and improved gap-fill characteristics. In the present method, a fluorinated silicon source, an optional fluorine source, an optional carbon source, a hydrogen source, and an oxygenator are used as the reactant gases. Inert or carrier gas(es) may also be used. In accordance with the present invention, the reactant gas mixture does not comprise a silane compound having the general formula SixHy, wherein x has a range of 1 to 2, y has a range of 4 to 6. The material deposited is thus referred to herein alternatively as “SixFy-only FSG” or “SixFy-only fluorinated oxide” (“SOFO”).Type: GrantFiled: November 15, 2005Date of Patent: June 24, 2008Assignee: Applied Materials, Inc.Inventors: Seong-Oh Woo, Jun Tae Choi
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Patent number: 7390758Abstract: A sealed type container accommodating a semiconductor substrate is positioned to a load port of a semiconductor manufacturing apparatus. The semiconductor substrate is taken out of the container. An ionizer is used for static-eliminating the semiconductor substrates before and after process treatment in a transport area between the load port and a treatment section. The static-eliminated semiconductor substrate is accommodated in the container positioned to the load port. Thus, it is possible to decrease foreign materials adhering to the semiconductor substrate and errors in handling the semiconductor substrate.Type: GrantFiled: January 26, 2007Date of Patent: June 24, 2008Assignee: Renesas Technology Corp.Inventor: Yoshiaki Kobayashi
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Patent number: 7390759Abstract: The invention provides a steel plate reinforcing sheet having light weight and thin layer, providing sufficient adhesion and reinforcing effect to a steel plate, and having excellent workability. In the steel plate reinforcing sheet comprising a restricting layer and a resin layer, a curing composition is first prepared by mixing rubber components comprising diene-based rubber and rubber having a vinyl group in its side chain, with a cross-linking agent capable of reacting with these rubber components, and then by kneading the mixture. Thereafter, the curing composition thus prepared is rolled by molding, to form a resin layer. Then, the resin layer thus formed is adhesively bonded to the restricting layer, to produce a steel plate reinforcing sheet.Type: GrantFiled: November 16, 2006Date of Patent: June 24, 2008Assignee: Nitto Denko CorporationInventors: Yasuhiko Kawaguchi, Katsuhiko Tachibana
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Patent number: 7390760Abstract: A composite material comprising a plurality of nanofibers intertwined with a plurality of coarse fibers to form one or more layers is provided. The nanofibers can be any suitable type of nanofiber, including electrospun fibers. A composite material comprising a plurality of electrospun fibers intertwined with a plurality of coarse fibers to form a single layer is also provided. A composite material comprising a plurality of electrospun fibers combined with a plurality of coarse fibers to form a plurality of layers, i.e., a multi-layer material, is also provided. In some embodiments, gradients in one or more directions are produced. Embodiments of the invention also provide processes for producing the composite nanofiber material. The materials are useful for any type of disposable garment, wipe, hospital garment, face mask, sterile wrap, air filter, water filter and so forth. Materials described herein can provide strong and varying surface effects, such as wicking.Type: GrantFiled: November 2, 2004Date of Patent: June 24, 2008Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Fung-jou Chen, Lei Huang, Jeffrey D. Lindsay
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Patent number: 7390761Abstract: The invention relates to an alkaline-earth aluminosilicate glass with the following composition (in wt. %, based on oxide content): SiO2 >58-62; B2O3 0 5.5; Al2O3 13.5 17.5; MgO 0-7; CaO 5.5-14; SrO 0-8, BaO 6-14; ZrO2 0-2; CeO2 0.001 0.5; TiO2 0.01-2. The glass is particularly suitable for use as a bulb material for halogen light bulbs.Type: GrantFiled: January 29, 2003Date of Patent: June 24, 2008Assignee: Schott AGInventors: Joery Hinrich Fechner, Peter Brix, Franz Ott
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Patent number: 7390762Abstract: A method for synthesizing high-content NaY molecular sieves with kaolin sprayed microspheres includes adding functional components and deionized water into kaolin so as to be pulped into a mixed slurry. The slurry is sprayed into microspheres. The microspheres are calcined at a temperature between 700 and 1,000° C. and mixed with a directing agent for crystallization. The resultant solid is filtrated and washed with water and then dried to obtain a final in-situ crystallized product with high content of molecular sieves.Type: GrantFiled: November 23, 2005Date of Patent: June 24, 2008Assignee: PetroChina Company LimitedInventors: Xionghou Gao, Honghai Liu, Baojie Wang, Changyan Duan, Xinmei Pang, Li Zhang, Lianhong Zhao, Jiangang Ma, Yunheng Liu
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Patent number: 7390763Abstract: The invention is directed to a method of making a small crystal SSZ-32 zeolite, known as SSZ-32X. The catalyst is suitable for use in a process whereby a feed including straight chain and slightly branched paraffins having 10 or more carbon atoms is dewaxed to produce an isomerized product, with increased yield of isomerized material and decreased production of light ends.Type: GrantFiled: October 31, 2003Date of Patent: June 24, 2008Assignee: Chevron U.S.A. Inc.Inventors: Stacey I. Zones, Guang Zhang, Kamala R. Krishna, Joseph A. Biscardi, Paul Marcantonio, Euthimios Vittoratos
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Patent number: 7390764Abstract: This invention provides catalyst compositions that are useful for polymerizing at least one monomer to produce a polymer This invention also provides catalyst compositions that are useful for polymerizing at least one monomer to produce a polymer, wherein said catalyst composition comprises a post-contacted organometal compound, a post-contacted organoaluminum compound, and a post-contacted fluorided silica-alumina.Type: GrantFiled: December 12, 2005Date of Patent: June 24, 2008Assignee: Phillips Petroleum CompanyInventors: Max P. McDaniel, Elizabeth A. Benham, Michael D. Jensen, Joel L. Martin, Gil R. Hawley
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Patent number: 7390765Abstract: Low-cure powder coating compositions are disclosed. The compositions comprise a polyepoxide and a material having the structure wherein R1 is an organic radical having 6 to 25 carbon atoms; R2 is an organic radical having 1 to 20 carbon atoms; R3 and R4 are independently alkyl or phenyl groups having 1 to 8 carbon atoms; Z is oxygen or nitrogen, and when Z is oxygen R5 is absent and when Z is nitrogen R5 is hydrogen or is and n is 1 to 4. The material can optionally be reacted with an acidic hydrogen-containing compound. The compositions are curable without the use of crosslinking agents or accelerators. Methods for coating a substrate using these compositions, and substrates coated thereby, are also disclosed, as are additional catalysts useful for the same purpose.Type: GrantFiled: June 5, 2007Date of Patent: June 24, 2008Assignee: PPG Industries Ohio, Inc.Inventors: Anthony M. Chasser, Shawn P. Duffy, Ronald R. Ambrose
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Patent number: 7390766Abstract: Stable catalyst carrier impregnating solutions can be prepared using a component of a Group VIB metal, e.g., molybdenum, at high concentration, a component of a Group VIII metal, e.g., nickel, at low concentration, and a phosphorous component, e.g., phosphoric acid, at low concentration, provided that the Group VIII metal is in a substantially water-insoluble form and a particular sequence of addition of the components is followed, even when a substantially water-insoluble form of the Group VIB component is used. The resulting stabilized impregnating solution can be supplemented with additional Group VIII metal in water-soluble form to achieve increased levels of such metal in the final catalyst. Furthermore, uncalcined catalyst carriers impregnated with the stable solution and subsequently shaped, dried and calcined, have unexpectedly improved performance when used in the hydroprocessing of heavy hydrocarbon feedstocks.Type: GrantFiled: November 20, 2003Date of Patent: June 24, 2008Inventor: Darryl P. Klein
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Patent number: 7390767Abstract: This invention relates generally to a method for producing fullerene nanotube catalyst supports and compositions thereof. In one embodiment, fullerene nanotubes or fullerene nanotube structures can be employed as the support material. A transition metal catalyst is added to the fullerene nanotubes. In a preferred embodiment, the catalyst metal cluster is deposited on the open nanotube end by a docking process that insures optimum location for the subsequent growth reaction. The metal atoms may be subjected to reductive conditions.Type: GrantFiled: August 22, 2006Date of Patent: June 24, 2008Assignee: William Marsh Rice UniversityInventors: Richard E. Smalley, Daniel T. Colbert, Hongjie Dai, Jie Liu, Andrew G. Rinzler, Jason H. Hafner, Ken Smith, Ting Guo, Pavel Nikolaev, Andreas Thess
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Patent number: 7390768Abstract: The invention described herein involves a novel approach to the production of oxidation/reduction catalytic systems. The present invention serves to stabilize the tin oxide reducible metal-oxide coating by co-incorporating at least another metal-oxide species, such as zirconium. In one embodiment, a third metal-oxide species is incorporated, selected from the group consisting of cerium, lanthanum, hafnium, and ruthenium. The incorporation of the additional metal oxide components serves to stabilize the active tin-oxide layer in the catalytic process during high-temperature operation in a reducing environment (e.g., automobile exhaust). Moreover, the additional metal oxides are active components due to their oxygen-retention capabilities. Together, these features provide a mechanism to extend the range of operation of the tin-oxide-based catalyst system for automotive applications, while maintaining the existing advantages.Type: GrantFiled: January 22, 2002Date of Patent: June 24, 2008Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Jeffrey D. Jordan, David R. Schryer, Patricia P. Davis, Bradley D. Leighty, Anthony Neal Watkins, Jacqueline L. Schryer, Donald M. Oglesby, Suresh T. Gulati, Jerry C. Summers
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Patent number: 7390770Abstract: A catalyst for purifying an exhaust gas containing carbon monoxide and volatile organic compounds, which has a coat layer of a carrier composed of a porous inorganic compound, wherein the coat layer is a single layer, the porous inorganic compound has a BET specific surface area of 50 m2/g or greater, and the coat layer has, within a 50 ?m depth from the surface thereof, an active metal having a particle size of 15 nm or less and composed of at least one noble metal.Type: GrantFiled: April 14, 2006Date of Patent: June 24, 2008Assignee: Mitsubishi Heavy Industries, Ltd.Inventors: Katsumi Nochi, Masanao Yonemura, Yoshiaki Obayashi, Toshiyuki Onishi
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Patent number: 7390771Abstract: The present invention provides a composition and a recording material made from the composition having an excellent dynamic sensitivity in recording as well as an excellent image stability and, particularly, having excellent resistance for heat and humidity, heat, light, plasticizer and water. The composition and the recording material include the following compounds (1), (2), and (3): wherein R1, R2, R6, R7, R11, and R12 each represents hydrogen or an alkyl group; a1 to a3 each represents an integer of 1-6; n1 to n3 each represents 0, 1 or 2; m1, m4 and m7 each represents 0, 1, 2 or 3; R3, R4, R8, R9, R13 and R14 each represents an alkyl group; m2, m3, m5, m6, m8 and m9 each represents 0, 1 or 2; and Y1 to Y3 each represents CO or NRCO (R represents hydrogen, etc.).Type: GrantFiled: November 30, 2004Date of Patent: June 24, 2008Assignee: Nippon Soda Co., Ltd.Inventors: Tadashi Kawakami, Shinichi Sato, Hiroshi Fujii
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Patent number: 7390772Abstract: The present invention is directed to novel compounds of the general formula wherein R and R1 independently represent a hydrogen or a straight, branched or cyclic hydrocarbon moiety consisting of less than 15, preferably less than 10, most preferably less than 4 carbon atoms and containing single and/or double bonds. Another embodiment of the invention is a method for enhancing a perfume composition by incorporating an olfactory acceptable amount of the compound provided above.Type: GrantFiled: May 18, 2006Date of Patent: June 24, 2008Assignee: International Flavor & Fragrances Inc.Inventors: Anubhav P. S. Narula, Edward Mark Arruda, Patrick M. Merritt, Franc T. Schiet
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Patent number: 7390773Abstract: An aqueous tire wheel cleaner composition useful for cleaning automobile tires are provided. The aqueous tire wheel cleaner composition contains an alkylene glycol, a salt of dialkyl sulfosuccinate, and as surfactants ethanol amine and an ethoxylate phosphate ester.Type: GrantFiled: October 30, 2006Date of Patent: June 24, 2008Assignee: Shell Oil CompanyInventor: Liliana Minevski
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Patent number: 7390774Abstract: Antimicrobial compositions and methods of making and using the same are disclosed. The disclosed antimicrobial compositions provide persistent, broad spectrum, antimicrobial activity. The antimicrobial compositions may be used in the preparation of antimicrobial articles. The antimicrobial compositions may also be used to inhibit the growth of microorganisms by introducing those compositions onto or into an environment subject to microbial attack.Type: GrantFiled: March 3, 2005Date of Patent: June 24, 2008Assignee: Rohm and Haas CompanyInventors: Tirthankar Ghosh, Barry Weinstein
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Patent number: 7390775Abstract: Surfactant-thickened active chlorine-containing bleach compositions including at least one water soluble anionic styrenic polymer are described. The styrenic polymer serves to improve the rheology properties of the thickened bleach composition. The thickened bleach composition additionally includes a surfactant-based thickening system including an amine oxide, and an alkaline agent to maintain the pH of the composition at about 10 or greater. The amine oxide includes at least 75% of one or more C14-C18 alkyl dimethyl amine oxides. The thickened bleach compositions have reduced viscosity, decreased elastic properties, with improved flow and pour properties resulting from the inclusion of the styrenic polymer.Type: GrantFiled: March 7, 2005Date of Patent: June 24, 2008Assignee: S.C. Johnson & Son, Inc.Inventors: Wayne M. Rees, Susan L. Bryant
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Patent number: 7390776Abstract: A liquid detergent builder which is highly compatible with a surfactant and gives transparent liquid detergents having extremely excellent detergency, a liquid detergent containing the builder, and a liquid detergent containing an acrylic acid-based polymer (salt) having excellent clay dispersibility and good compatibility with a surfactant. The liquid detergent builder comprises an acrylic acid/maleic acid-based copolymer (salt), wherein the acrylic acid/maleic acid-based copolymer (salt) contains maleic acid (salt) in an amount of 5-90 mol % per mole of the sum of acrylic acid (salt) and maleic acid (salt), and a product (MA×Mw) of a weight average molecular weight (Mw) of the copolymer (salt) and a proportion (MA (mol %)) of the maleic acid (salt) in the copolymer (salt) is 450,000 or less.Type: GrantFiled: September 11, 2003Date of Patent: June 24, 2008Assignee: Nippon Shokubai Co., Ltd.Inventors: Takahiro Tsumori, Atsuro Yoneda, Akiko Hemmi, Shigeru Yamaguchi
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Patent number: 7390777Abstract: Describes compositions of 1,2-dichloroethylene, particularly trans-1,2-dichloroethylene, stabilized with effective stabilizing amounts of a combination of (a) C3 to C12 alkylene oxide, e.g., butylene oxide, (b) alcohol chosen from aliphatic and cycloaliphatic alcohols having from 2 to 8 carbon atoms, e.g., isopropanol, and (c) a material chosen from (i) C1 to C5 alkoxyphenol, e.g., 4-methoxyphenol, (ii) free radical stabilizer having at least one 2,2,6,6-tetra(lower alkyl)-1-piperidinyloxy-yl group, and (iii) mixtures of (i) and (ii). Also describes use of such compositions for vapor degreasing of soiled articles, e.g., metal parts and soldered circuit boards.Type: GrantFiled: February 13, 2004Date of Patent: June 24, 2008Assignee: PPG Industries Ohio, Inc.Inventors: Michael P. Dobrasko, Ronald D. Olinger
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Patent number: 7390778Abstract: A composition for treating fabrics, comprising: a) a fabric shrinkage reducing composition selected from the group consisting of ethylene glycol, all isomers of propanediol, butanediol, pentanediol, hexanediol and mixtures thereof; b) a liquid cleaning/refreshment composition. The fabric shrinkage reducing composition and the liquid cleaning/refreshment composition are releasably absorbed in a substrate in a weight ratio of from about 1:2 to about 1:5. The fabric shrinkage reducing composition helps to reduce shrinkage of the fabrics treated in an in-home, non-immersion cleaning and refreshing process which is conducted in a clothes dryer, or the like apparatus. Also provided are non-immersion cleaning/refreshment processes using this composition, a kit containing the necessary items to conduct the processes of this invention and a sheet for releasably absorbing the compositions of this invention.Type: GrantFiled: August 24, 1999Date of Patent: June 24, 2008Assignee: The Procter & Gamble CompanyInventors: Janine Morgens Strang, Michael Peter Siklosi
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Patent number: 7390779Abstract: Odourant compounds selected from compounds having the structure: wherein, R1 and R2 may be independently hydrogen or methyl, and n is an integer 1, 2 or 3 provided that n+ the carbon atoms in R1 and R2 is less than 5, their preparation and their use in fine fragrances and perfume components, wherein the compounds provide a musk characteristic.Type: GrantFiled: May 30, 2002Date of Patent: June 24, 2008Assignee: Givaudan SAInventors: Philip Kraft, Riccardo Cadalbert
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Patent number: 7390780Abstract: A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a hydrophilic polymer by a releasable linkage. The liposomes are associated with a nucleic acid for delivery to a cell.Type: GrantFiled: November 19, 2004Date of Patent: June 24, 2008Assignee: Alza CorporationInventors: Shi-Kun Huang, Samuel Zalipsky
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Patent number: 7390781Abstract: Disclosed are novel proteins, referred to as truncated glial cell line-derived neurotrophic factor (truncated GDNF) proteins, that promote dopamine uptake by dopaminergic cells and promote the survival of nerve cells. Also disclosed are processes for obtaining the truncated GDNF proteins by recombinant genetic engineering techniques.Type: GrantFiled: January 7, 2004Date of Patent: June 24, 2008Assignee: Amgen Inc.Inventor: Shaw-Fen Sylvia Hu
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Patent number: 7390782Abstract: The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The invention also involves related compositions and screening assays.Type: GrantFiled: March 17, 2004Date of Patent: June 24, 2008Assignee: University of Vermont and State Agricultural CollegeInventor: Martha Karen Newell
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Patent number: 7390783Abstract: The invention provides a pharmaceutical composition comprising a synthetic or naturally occurring charged phospholipid, which is formulated into a dosage form for administration to a subject or which is administered as a food additive. Negatively charged phospholipid composition increase the net negative charge on intravascular lipoproteins, enhance the clearance of cholesterol and regulate the function of lipolytic enzymes, retard prothrombin formation and aid in the clearance of virus and bacterial particles. Negatively charged lipid compositions can therefore be administered to humans and animals for the treatment of hyperlipidemia and blood coagulation disorders and to reduce the levels of virus, bacteria, and endotoxins in the blood stream. Positively charged lipid compositions can be administered to delay lipoprotein clearance from the plasma compartment and give longer duration of activity for drugs which are associated with lipoproteins.Type: GrantFiled: October 4, 2004Date of Patent: June 24, 2008Assignees: Ottawa Heart Institute Research Corporation, Liponex Inc.Inventor: Daniel L. Sparks
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Patent number: 7390784Abstract: Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. In the subject methods, an effective amount of the bifunctional molecule is administered to the host. The bifunctional molecule binds to the presenter protein to produce a binary complex that exhibits at least one of improved affinity, specificity or selectivity as compared to the corresponding free drug. The subject methods and compositions find use in a variety of therapeutic applications.Type: GrantFiled: December 13, 2004Date of Patent: June 24, 2008Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Roger Briesewitz, Gerald R. Crabtree, Thomas Wandless, Gregory Thomas Ray, Kurt W. Vogel
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Patent number: 7390785Abstract: The invention relates to relatively short peptides (termed ?-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.Type: GrantFiled: November 7, 2005Date of Patent: June 24, 2008Assignees: The University of Utah Research Foundation, Cognetix, Inc.Inventors: Craig Walker, Reshma Shetty, Baldomero M. Olivera, David Hooper, Richard Jacobsen, Doug Steel, Robert Jones
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Patent number: 7390786Abstract: Protein formulations and methods for reducing the viscosity of a protein formulation are provided. The method for reducing the viscosity of a protein formulation comprises adding a viscosity reducing agent, such as calcium chloride or magnesium chloride to the protein formulation.Type: GrantFiled: December 21, 2006Date of Patent: June 24, 2008Assignee: WyethInventors: Nicholas W. Warne, Pilarin Elizabeth Louise Nichols, Paulo Jorge Loureiro
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Patent number: 7390787Abstract: Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.Type: GrantFiled: January 24, 2003Date of Patent: June 24, 2008Assignee: Migenix Inc.Inventors: Janet R. Fraser, Michael H. P. West, Timothy J. Krieger, Robert Taylor, Douglas Erfle
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Patent number: 7390788Abstract: The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example insulin and Peptide T or analog thereof.Type: GrantFiled: June 23, 2006Date of Patent: June 24, 2008Inventors: Candace B. Pert, Michael R. Ruff
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Patent number: 7390789Abstract: The present invention is directed to an ? thio-containing compound that is capable of inhibiting the enzyme, membrane aminopeptidase P (mAPP or APP), whose natural substrate is bradykinin. The compound is useful as a pharmaceutical agent because by inhibiting bradykinin degradation, the compound allows bradykinin to exert its beneficial effects on the cardiovascular system, to improve renal function, and to improve glucose tolerance and insulin-sensitivity. The present invention is also directed to a pharmaceutical composition comprising the mAPP inhibitor of the present invention and a pharmaceutically acceptable carrier. In another aspect, the present invention is directed to a method of inhibiting bradykinin degradation in a mammalian patient, preferably human, in need of treatment comprising administering to the patient a therapeutically effective amount of an ? thio-containing compound of the present invention.Type: GrantFiled: September 13, 2005Date of Patent: June 24, 2008Inventor: William H Simmons
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Patent number: 7390790Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.Type: GrantFiled: October 10, 2006Date of Patent: June 24, 2008Assignee: Sanofi-Aventis Deutschland GmbHInventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
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Patent number: 7390791Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.Type: GrantFiled: March 11, 2004Date of Patent: June 24, 2008Assignee: Gilead Sciences, Inc.Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
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Patent number: 7390792Abstract: Delta protein expression in a cell is reduced by introducing miR-1 into the cell, and detecting a resultant reduction of Delta protein expression in the cell.Type: GrantFiled: December 15, 2005Date of Patent: June 24, 2008Assignee: Board of Regents, The University of Texas SystemInventors: Deepak Srivastava, Chulan Kwon
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Patent number: 7390793Abstract: The present invention provides micelles, solutions comprising micelles, methods for preparing micelles, and methods for delivering micelles to patients. The micelles have fixed, preselected hydrodynamic diameters and are formed from basic or acidic amphiphilic compounds.Type: GrantFiled: April 15, 2005Date of Patent: June 24, 2008Assignee: Eisai Co., Ltd.Inventors: James McShane, Tori Arens, Kazuhiro Kaneko, Tomohiro Watanabe, Kazuhide Ashizawa
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Patent number: 7390795Abstract: A method for the treatment or prevention of tissue damage in a subject having an inflammatory and/or tissue damaging condition, which comprises administering to the subject an effective amount of a compound capable of inhibiting the binding of C-reactive protein (CRP) to an autologous or extrinsic ligand.Type: GrantFiled: December 18, 2000Date of Patent: June 24, 2008Assignee: Pentraxin Therapeutics LimitedInventor: Mark B. Pepys
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Patent number: 7390796Abstract: Compounds are disclosed of the formula in which R3 is C8 to C24 hydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.Type: GrantFiled: November 14, 2006Date of Patent: June 24, 2008Assignee: Sepracor Inc.Inventors: Mark G. Currie, Steven Jones, Charles M. Zepp
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Patent number: 7390797Abstract: The present invention provides a novel fused indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein Z11 and Z12 each independently represent a carbonyl group, a methylene group, etc.; represents a double bond or a single bond; R1a represents a hydrogen atom, etc.; the ring A represents a benzene ring, a naphthalene ring or a 5- to 10-membered aromatic heterocyclic ring, etc.; and R2a, R2b and R2c each independently represent (1) a hydrogen atom, (2) a halogen atom, (3) a nitro group, etc.Type: GrantFiled: February 21, 2003Date of Patent: June 24, 2008Assignee: Eisai Co., Ltd.Inventors: Norihito Ohi, Nobuaki Sato, Naohiro Kohmura
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Patent number: 7390798Abstract: The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache.Type: GrantFiled: February 9, 2005Date of Patent: June 24, 2008Assignee: Merck & Co., Inc.Inventors: Theresa M. Williams, Christopher S. Burgey, Thomas J. Tucker, Craig A. Stump, Ian M. Bell
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Patent number: 7390799Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.Type: GrantFiled: May 12, 2006Date of Patent: June 24, 2008Assignee: Abbott LaboratoriesInventors: Milan Bruncko, Hong Ding, Steven W. Elmore, Aaron R. Kunzer, Christopher L. Lynch, William J. McClellan, Cheol Min Park, Xiahong Song, Xilu Wang
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Patent number: 7390800Abstract: The present invention relates to an adenosine deaminase inhibitor and a novel Bacillus sp. strain which produces it. Particularly, the present 5 invention relates to the adenosine deaminase inhibitor, and the novel Bacillus sp. IADA-7 producing the above adenosine deaminase inhibitor. The adenosine deaminase inhibitor of the present Invention shows superior antibacterial and anticancer activities to the previously reported adenosine deaminase inhibitors.Type: GrantFiled: March 24, 2004Date of Patent: June 24, 2008Assignee: FCB-Pharmicell Co., Ltd.Inventors: Gwang Lee, Young Hwan Ahn, Ki Ho Park, Hong Ki Jun
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Patent number: 7390801Abstract: Disclosed are compounds which inhibit ?-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ?-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.Type: GrantFiled: May 12, 2006Date of Patent: June 24, 2008Assignees: Athena Neurosciences, Inc., Eli Lilly and CompanyInventors: Eugene D. Thorsett, Michael A. Pleiss, Lee H. Latimer, Varghese John, Stephen Freedman, Thomas C. Britton, James A. Audia, Jon K. Reel, Bruce A. Dressman, James J. Droste, Steven S. Henry, Russell D. Stucky, Warren J. Porter
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Patent number: 7390802Abstract: This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A?-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to ?-amyloid production such as Alzheimer's disease and Down's Syndrome.Type: GrantFiled: January 19, 2007Date of Patent: June 24, 2008Assignee: Bristol-Myers Squibb Pharma CorporationInventors: Qi Han, Hong Liu, Richard E. Olson, Michael G. Yang
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Patent number: 7390803Abstract: The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity.Type: GrantFiled: October 24, 2003Date of Patent: June 24, 2008Assignee: Merck & Co., Inc.Inventors: Gabor Butora, Sander G. Mills, Alexander Pasternak, Kothandaraman Shankaran, Lihu Yang, Changyou Zhou, Stephen D. Goble
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Patent number: 7390804Abstract: An N-containing five-membered ring compound of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of inflammatory diseases, diseases induced by apoptosis, diseases induced by disorders of immune responses, autoimmune diseases, diseases induced by decomposition of proteins which compose organism, shock, circulatory system disorders, blood coagulation systems disorders, malignant tumors, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitic diseases, nerve degeneration diseases, pulmonary disorders, bone resorption diseases, endocrinesthenia, etc.Type: GrantFiled: December 22, 2004Date of Patent: June 24, 2008Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Kazuyuki Ohmoto, Iori Itagaki
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Patent number: 7390805Abstract: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.Type: GrantFiled: March 14, 2007Date of Patent: June 24, 2008Assignee: Novartis AGInventors: Guido Bold, Hans-Georg Capraro, Giorgio Caravatti, Peter Traxler
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Patent number: 7390806Abstract: The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.Type: GrantFiled: June 14, 2004Date of Patent: June 24, 2008Assignee: Anacor Pharmaceuticals, Inc.Inventors: Ving Lee, Stephen J. Benkovic, Stephen J. Baker, Kirk R. Maples, Tsutomu Akama, Yong-Kang Zhang, Rajeshwar Singh, Vittorio A. Sauro, Chetan Pandit, Zhuoyi Su, Zhixiang Yang
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Patent number: 7390807Abstract: The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes for preparing the new crystal forms of lamotrigine.Type: GrantFiled: January 31, 2005Date of Patent: June 24, 2008Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Nissim Garti, Yana Berkovich, Ben-Zion Dolitzky, Judith Aronhime, Claude Singer, Anita Liebermann, Neomi Gershon