Patents Issued in July 8, 2008
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Patent number: 7396489Abstract: A plasma display device including a green phosphor of which brightness is hardly deteriorated and a production method therefore are disclosed. The plasma display device comprises a plasma display panel in which a plurality of discharge cells of one color or a plurality of colors are disposed, red phosphor layers 110R, green phosphor layers 110G, and blue phosphor layers 110B are arranged correspondingly to the respective discharge cells, and the red phosphor layers 110R, the green phosphor layers 110G, and the blue phosphor layers 110B are excited by ultraviolet rays to emit light. The green phosphor layers 110G include a green phosphor expressed by (Ma-x-yEuxTby)O.MgO.2SiO2 (here, M is at least one element selected from Ca, Sr, and Ba).Type: GrantFiled: December 13, 2004Date of Patent: July 8, 2008Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Keiji Horikawa, Yuichiro Miyamae, Masaki Aoki, Kazuhiko Sugimoto, Junichi Hibino, Yoshinori Tanaka, Hiroshi Setoguchi
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Patent number: 7396490Abstract: A UV-emitting, Ce,Pr-coactivated calcium pyrophosphate phosphor is provided wherein the Pr activator increases the phosphor's sensitivity to excitation by 185 nm radiation. The improved sensitivity to the 185 nm radiation allows the phosphor to make better use of the approximate 10% of the UV radiation that is emitted at 185 nm by a low pressure mercury discharge.Type: GrantFiled: April 6, 2006Date of Patent: July 8, 2008Assignee: Osram Sylvania Inc.Inventors: Gregory A. Marking, Thomas M. Synder
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Patent number: 7396491Abstract: A UV-emitting phosphor and lamp containing same are described. The phosphor is a praseodymium-activated pyrophosphate-based phosphor which may be represented by the general formula (Ca2-x,Srx)P2O7:Pr where 0?x?2. The phosphor is excitable by vacuum ultraviolet (VUV) radiation and in particular it may be excited by Xe-excimer discharges and thereby provide a Hg-free UV-emitting lamp. The phosphor exhibits a broad emission in the UVC region in the wavelength range from about 220 nm to about 280 nm with the peak emission occurring in the wavelength range from about 230 nm to about 240 nm. The emission characteristics of the phosphor may be varied depending on the ratio of Sr/Ca.Type: GrantFiled: April 6, 2006Date of Patent: July 8, 2008Assignee: Osram Sylvania Inc.Inventors: Gregory A. Marking, Thomas M. Synder
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Electrically conductive resin compounds based on polyoxymethylene and highly structured carbon black
Patent number: 7396492Abstract: This invention in one aspect is a polyoxymethylene compound exhibiting an improved balance of properties and volume resistivity of 100-106 ohm-cm, which comprises polyoxymethylene, polyethylene glycol, metal oxide, high-structure carbon black and a comb polymer. The invention is more particularly directed to a polyoxymethylene compounds and molded articles therefrom in which the compound comprises 30 to 98.7% by weight of a polyoxymethylene homopolymer or copolymer, from 0.1 to 10% by weight of a polyalkylene glycol, from 0.1 to 10% by weight of metal oxide, from 1% to 15% of a high structured particulate carbon black, and from 0.1 to 15% by weight of a comb polymer containing a relatively less polar backbone with relatively more polar side chains.Type: GrantFiled: March 30, 2006Date of Patent: July 8, 2008Inventors: Kenneth Leon Price, Jeroen Franklin Visjager, Stefan Kutta -
Patent number: 7396493Abstract: Polymeric multilayer optical films, and laminate bodies that include such films, are provided with a melt zone that extends between a first and second portion of the multilayer optical film. If a shearing operation or other external influence acts on the film in the first portion that causes delamination of individual layers of the multilayer optical film, the melt zone is effective to prevent the delamination from propagating from the first portion to the second portion. The melt zone is characterized at least in part by a deformation of individual layers of the multilayer optical film. The melt zone can be positioned to extend along and proximate to some or all of a periphery of the multilayer optical film.Type: GrantFiled: October 10, 2002Date of Patent: July 8, 2008Assignee: 3M Innovative Properties CompanyInventors: Bruce E. Tait, Steven J. Dobrzynski, David K. Mortenson, John A. Wheatley
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Patent number: 7396494Abstract: Disclosed herein is a composite film comprising an organic polymer film; the organic polymer film having an elastic modulus of less than or equal to about 105 gigapascals when measured at room temperature; and a bundle of carbon fibers disposed in the organic polymer film; each bundle comprising a column and an end face; each bundle also having a longitudinal axis that is substantially parallel to the column and passes through the center of the column; the end face being fibrillated so as to have a surface area measured perpendicular to the longitudinal axis that is about 110 to about 250% greater than the surface area of a cross-section of the carbon fiber measured at the column.Type: GrantFiled: November 27, 2007Date of Patent: July 8, 2008Assignee: International Business Machines CorporationInventors: Kuniaki Sueoka, Yoichi Taira
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Patent number: 7396495Abstract: A method for producing a block having a flat bottom, a flat top which is parallel to the bottom and sidewalls which extend between the bottom and the top is disclosed. At least three cooperating mold parts are assembled on a first plate to produce assembled mold parts having interior surfaces which conform with the shape of the sidewalls of the block and flat, coplanar tops and bottoms. The assembled mold parts are clamped together, and a high slump concrete which is hardenable by hydration of cement therein is charged and worked as required into close proximity to the interiors of the mold parts and to the plate inside the mold parts. A foamable composition capable of forming a body of a thermoset, closed cell, urethane foam having a density of about 10 to 60 pounds per cubic foot which fills the interior of the assembled mold parts above the concrete therein is then charged, and a second plate is clamped over the tops of the mold parts.Type: GrantFiled: September 29, 2004Date of Patent: July 8, 2008Inventor: Charles E. Friesner
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Patent number: 7396496Abstract: Procedure for fabrication of reinforcement elements for concrete, where an extended, preferably continuously fiber bundle (10), especially of carbon fibers, impregnates (3) by a matrix of a plastic material followed by curing. The fiber bundle (10), including a significant amount of single fibers, is brought after impregnation (3) and prior to curing (17) to cooperate with a particle shaped material (15), preferably sand, as adhere to the fiber bundle surface mainly without coming in between the fibers and fixate to the surface by curing, for creation of a reinforcement element.Type: GrantFiled: September 16, 2002Date of Patent: July 8, 2008Assignee: BBA Blackbull ASInventor: Anders Henrik Bull
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Patent number: 7396497Abstract: The present invention provides a method of forming a chemical mechanical polishing pad, comprising providing a tank with polymeric materials and providing a storage hopper with microspheres having an initial bulk density, wherein the storage hopper further comprises a porous membrane provided over a plenum. The method further provides the steps of connecting a fluidizing gas source to the plenum through a gas inlet line and fluidizing the microspheres and reducing the initial bulk density by feeding gas into the plenum. In addition, the method further provides the steps of providing a delivery system for delivering the polymeric materials and the microspheres to a mixer, forming a mixture of the polymeric materials and the microspheres, pouring the mixture into a mold to form a molded product and cutting the molded product into the polishing pad.Type: GrantFiled: September 30, 2004Date of Patent: July 8, 2008Assignee: Rohm and Haas Electronic Materials CMP Holdings, Inc.Inventors: Joseph P. Koetas, Alan E. Leviton, Kari-Ell Norton, Samuel J. November, Malcolm W. Robertson, Alan H. Saikin
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Patent number: 7396498Abstract: The invention disclosed herein relates to a method of treating plastics material fibers, filaments or film to improve their resistance to degradation by UV radiation and/or increase their resistance to gas (oxygen) transmissivity and an improved plastics material so treated, the method including stretching the fiber, filament or film beyond its yield point and allowing the film to at least partially relax.Type: GrantFiled: June 23, 1999Date of Patent: July 8, 2008Assignee: Integrated Packaging Australia Pty. Ltd.Inventor: Peter Johnstone
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Patent number: 7396499Abstract: A multi-layer article includes a fluoropolymer layer and a substrate which are joined permanently through a multi-step cross-linking technique.Type: GrantFiled: September 28, 2004Date of Patent: July 8, 2008Inventors: Thomas E Frankel, Seoung-il Kang, Todd David Ritter, Hong-suk Kim
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Patent number: 7396500Abstract: The present invention thus provides a plastic part with a surface area of a semi-rigid sheet material such as metal, wood or wood-based paper product and a novel process where the sheet material edges are covered with a second plastic component that adheres both to the sheet material and to the first plastic material. A first plastic substrate component is prepared with an adhered sheet material surface area and then the edges of the sheet material are overlapped by a second molded-on, plastic edge-covering component. A preferred sheet material laminate structure is also provided with a backing layer that protects an interior adhesive layer. The second molded-on edge-covering component covers the sheet material edge to provide an aesthetically pleasing surface. This construction produces a more durable sheet material edge covering and eliminates the tendency of the sheet material to peel off the molded part during use.Type: GrantFiled: January 29, 2004Date of Patent: July 8, 2008Assignee: Dow Technologies Inc.Inventors: Vijay Wani, Michael E. Hus, Eric Marchbanks, Curt E. Peterson, Thomas Van Conett
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Patent number: 7396501Abstract: Use of gradient layers and stress modifiers in superhard constructs.Type: GrantFiled: August 27, 2004Date of Patent: July 8, 2008Assignee: Diamicron, Inc.Inventors: Bill J. Pope, Richard H. Dixon, Jeffery K. Taylor, Clayton F. Gardinier, Troy Medford, Dean C. Blackburn, Michael A. Vail, Louis M. Pope, Victoriano Carvajal
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Patent number: 7396502Abstract: The present invention provides a method for producing nano-sized Fe powder having a polymer coated layer on a surface thereof, so as to prevent the nano-sized Fe powder from being oxidized under atmosphere. The method includes: gasifying an iron pentacarbonyl (Fe(CO)5) or an iron acetate ((CH3CO2)2Fe) precursor in a ceramic bubbler; forming nano-sized Fe particles due to the crystallization of Fe gas while mixing the gasified precursor with Ar gas in a reactor; and precipitating the nano-sized Fe particles in a polymer solution in a chamber, before the nano-sized Fe particles are oxidized. According to this technique, Fe powder on the order of tens of nms in size, and having a polymer coated layer, are obtained from the Fe precursor. A system for producing the nano-sized Fe powder is also disclosed.Type: GrantFiled: November 3, 2004Date of Patent: July 8, 2008Assignee: Korea Institute of Machinery and MaterialsInventors: Byung Kee Kim, Dong Won Lee, Chul-Jin Choi
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Patent number: 7396503Abstract: A metallurgical lance for injecting particulate material into a liquid comprises a main gas tube 6 defining an axial main gas passage terminating at its outlet and in a first Laval nozzle 38 downstream of the throat of said nozzle. A shrouding gas passage in the form of a combustion chamber 36 surrounds the main gas tube and terminates in a second Laval nozzle 42. A particulate material transport tube 4 defines a passage for the particulate material to be introduced into the first Laval nozzle 38 downstream of its throat. The first Laval nozzle 38 is provided with a passage 40 for the flow of coolant.Type: GrantFiled: April 15, 2003Date of Patent: July 8, 2008Assignee: The BOC Group plcInventors: Andrew Miller Cameron, Christian Juan Feldermann
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Patent number: 7396504Abstract: The present invention comprises a sealed type container body (50) capable of storing molten metal; a flow passage (57) capable of flowing the molten metal, the passage is formed extended to an outside of the container, and the passage is formed towards an upper portion (57b) from an opening (57a) provided at a position on an inner and near a bottom portion (50a) of the container body (50); and means (101, 0313) for controlling the pressure in the container body. This makes it possible to provide a container or the like requiring no replacement of parts such as a stoke and the like.Type: GrantFiled: June 22, 2001Date of Patent: July 8, 2008Assignee: Hoei Shokai Co., Ltd.Inventors: Toru Kodama, Tsuyoshi Abe, Hiroshi Mizuno, Kazunori Suzuki, Kouji Iyoda, Kenji Noguchi
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Patent number: 7396505Abstract: CoCrMo can be used to enhance biocompatibility of a sintered polycrystalline diamond compact.Type: GrantFiled: August 27, 2004Date of Patent: July 8, 2008Assignee: Diamicron, Inc.Inventors: Bill J. Pope, Richard H. Dixon, Jeffery K. Taylor, Clayton F. Gardinier, Troy Medford, Dean C. Blackburn, Michael A. Vail, Louis M. Pope, Kenneth M. Jensen
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Patent number: 7396506Abstract: A method is described for the preparation of superconductor massive bodies of MgB2, having a density close to the theorical value, which comprises the following passages: mechanical activation of crystalline boron with the formation of activated powders; formation of a porous preform of said powders; assembly of the porous boron preform and massive precursors of metallic magnesium in a container and sealing thereof in an atmosphere of inert gas or with a low oxygen content; thermal treatment of the boron and magnesium as assembled above, at a temperature higher than 700° C. for a time greater than 30 minutes, with the consequent percolation of the magnesium, in liquid phase, through the activated crystalline boron powders.Type: GrantFiled: May 10, 2002Date of Patent: July 8, 2008Assignee: Edison, S.p.AInventors: Giovanni Giunchi, Sergio Ceresara
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Patent number: 7396507Abstract: The present invention provides a method of microbial reduction and/or sterilization of impression materials, specifically elastomeric impression materials, by means of steam sterilization.Type: GrantFiled: June 16, 2003Date of Patent: July 8, 2008Assignee: Heraus Kulzer GmbH & Co. KGInventors: Martin Grunwald, Birgit Esser
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Patent number: 7396508Abstract: Apparatus and methods for automatically staining or treating multiple tissue samples mounted on microscope slides are provided. Individualized slide temperature control is accomplished by the heating system according to the present invention that has thermal platforms radially mounted to the carousel for heating the slides and sensing the temperature of each. The heating system also permits automated de-waxing if necessary.Type: GrantFiled: July 12, 2000Date of Patent: July 8, 2008Assignee: Ventana Medical Systems, Inc.Inventors: William Richards, Charles D. Lemme, Kimberly Christensen, Ethel R. Macrea
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Patent number: 7396509Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.Type: GrantFiled: November 26, 2003Date of Patent: July 8, 2008Assignee: Gen-Probe IncorporatedInventor: Ralph E. Burns
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Patent number: 7396510Abstract: A microdosage device comprises a media reservoir used for accommodating a liquid to be dosed, a nozzle connected via a connecting channel to the media reservoir and adapted to be filled via said connecting channel with the liquid to be dosed, and a drive unit for applying, when actuated, to a liquid contained in the media reservoir and in the nozzle a force of such a nature that a substantially identical pressure will be exerted on said liquid contained in the media reservoir and in the nozzle. Flow resistances of the connecting channel and of the nozzle are dimensioned such that, in response to an actuation of the drive unit, a volumetric flow in the connecting channel will be small in comparison with a volumetric flow in the nozzle, said volumetric flow in the nozzle causing an ejection of the liquid to be dosed from an ejection opening of the nozzle.Type: GrantFiled: January 10, 2002Date of Patent: July 8, 2008Inventors: Roland Zengerle, Peter Koltay
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Patent number: 7396511Abstract: Proposed is dispensing technology capable of reliably spotting a biological sample on a solid phase. A head chip applies a voltage pulse between a diaphragm and separate electrodes based on a drive control signal output from a head driver IC, and discharges a solution containing protein filled in a pressurized chamber as a result of the elastic deformation of the diaphragm. A drive pulse generation circuit generates a drive voltage pulse and supplies this to the head chip in order to discharge a solution containing protein from the head chip. The drive current detection circuit detects a drive current flowing between the diaphragm and separate electrodes. Since the waveform of the detected drive current and the peak current value and so on differ in the case where the discharge status is normal and in the case where it is abnormal, a defective discharge can be discriminated by detecting such change.Type: GrantFiled: July 25, 2003Date of Patent: July 8, 2008Assignee: Seiko Epson CorporationInventors: Masahiro Fujii, Hiroshi Koeda, Fumio Takagi
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Patent number: 7396512Abstract: A rugged, all-electronic fluid dispensing system for use with pipettes or in other contexts indirectly measures fluid flow by using a non-linear system model to correlate vacuum existing at the top of a column of suspended fluid. Non-contact operation is provided to eliminate the need for contact-type closed-loop fluid flow sensing and associated potential cross-contamination risks. In one particular exemplary non-limiting illustrative implementation, an electronic controller within a gun-shaped, cordless self-contained pipetter housing dynamically calculates valve opening time based on a non-linear equation. Calibration is used to derive equation constants, and column vacuum pressure before the valve is opened is used as the independent variable to derive a valve opening time that will result in accurate dispensing of a desired programmed fluid quantity.Type: GrantFiled: November 4, 2003Date of Patent: July 8, 2008Assignee: Drummond Scientific CompanyInventors: Nicholas M. DiTrolio, Eric L. Canfield
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Patent number: 7396513Abstract: A process is provided for converting oxygenate to olefins from a fluidized bed reactor which comprises removal of catalyst fines from a quenched vaporous effluent by contacting with a liquid low in catalyst fines content, e.g., oxygenate feedstock, or by-product water from the oxygenates to olefins conversion which is stripped and/or filtered.Type: GrantFiled: March 6, 2006Date of Patent: July 8, 2008Assignee: ExxonMobile Chemical Patents Inc.Inventors: Cor F. Van Egmond, Zhong Yi Ding
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Patent number: 7396514Abstract: An electronic control system for regulating operational parameters in a pollution removal system. The pollution removal system may contain at least one reaction zone connected to a source of gas and a sorbent feeder containing a supply of sorbent. The system may include a pollutant concentration sensor that measures the concentration of at least one target pollutant in a gas exiting a reaction zone, a differential pressure sensor that measures the differential pressure across a reaction zone, a sorbent feed rate controller that regulates sorbent feed rate to the reaction zone, and a controller in communication with these elements. The controller may use the measured values to adjust sorbent feeder rate to ensure that the target pollutant concentration in a gas exiting the reaction zone is within an acceptable range and that differential pressure across the reaction zone is no greater than a predetermined level.Type: GrantFiled: May 20, 2005Date of Patent: July 8, 2008Assignee: EnviroScrub Technologies CorporationInventor: Charles F. Hammel
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Patent number: 7396515Abstract: A reactor with a reaction chamber (14), which is produced for example by etching or other micro-mechanical production processes. An agitating device (20) is formed for example by an electrical field generator (18), which acts on electrical charge carriers (21) of the sample fluid, and consequently leads to circulation or mixing of the sample fluid. As an alternative, a magnetic field generator which acts on magnetic particles in the sample fluid may also be used. The reactor permits the extensive miniaturization of test reactors for bioprocesses, since circulation of the fluid to achieve a quasi steady-state bioprocess is possible the agitating devices even under extremely confined spatial conditions.Type: GrantFiled: May 27, 2003Date of Patent: July 8, 2008Assignee: Siemens AktiengesellschaftInventors: Frank Arndt, Hendrik Rönsch, Arno Steckenborn
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Patent number: 7396516Abstract: A three-way catalyst (TWC) composition comprises a manganese-containing oxygen storage component (OSC) and at least one optionally doped alumina wherein where the at least one alumina is gamma-alumina it is doped with at least one of a rare earth metal, silicon, germanium, phosphorus, arsenic, calcium, strontium or barium.Type: GrantFiled: November 20, 2001Date of Patent: July 8, 2008Assignee: Johnson Matthey Public Limited CompanyInventors: Janet Mary Fisher, Timothy Ian Hyde, David Thompsett
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Patent number: 7396517Abstract: The hydrocarbon-assisted, selective catalytic reduction of NOx constituents in lean-bum engine exhaust is benefited by passage of the exhaust over a staged catalyst bed comprising a first stage of an alumina-supported silver catalyst for oxidation of NO to NO2 and partial oxidation of added hydrocarbon to an aldehyde. Downstream of the silver catalyst is a second catalyst selected for the reaction of hydrocarbon and aldehyde species with NO2 to reduce it to nitrogen. Gamma-alumina and BaY zeolite are examples of suitable second stage catalysts.Type: GrantFiled: August 5, 2005Date of Patent: July 8, 2008Assignee: GM Global Technology Operations, Inc.Inventor: Jong-Hwan Lee
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Patent number: 7396518Abstract: The present invention provides a method of high-temperature denitration characterized in that NOx in an exhaust gas is reduced at 450° to 800° C. using ammonia as a reducing agent in the presence of a catalyst which comprises zirconium oxide and SO3 or SO42? and has solid acid strength (Ho) of ?11.93 or lower. The present invention also provides a method of high temperature denitration characterized in that NOx in an exhaust gas is reduced at 450° to 800° C. using ammonia as a reducing agent in the presence of a catalyst wherein at least one of tungsten oxide, molybdenum oxide and boron oxide is supported on a carrier comprising zirconium oxide and SO3 or SO42? and having solid acid strength (Ho) of ?11.93 or lower.Type: GrantFiled: March 27, 2003Date of Patent: July 8, 2008Assignee: Hitachi Zosen CorporationInventors: Masayoshi Ichiki, Kazuhiro Yano, Susumu Hikazutani
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Patent number: 7396519Abstract: A high purity aqueous solution of hydroxylamine product is prepared by treating an aqueous solution of hydroxylammonium salt with a base like ammonia at low temperatures. A novel process can be carried out by separating the ammonium salt side product from hydroxylamine with a low temperature filtration and a resin-exchange process. The concentration of the hydroxylamine product is further improved by a safe distillation process that produces a high purity and high concentration hydroxylamine product with reduced risks of explosion.Type: GrantFiled: January 26, 2004Date of Patent: July 8, 2008Assignee: San Fu Chemical Company, Ltd.Inventors: Kaung-Far Lin, Jin-Fu Chen, Wei Te Lin, Ruey-Shing Chen, Kung-Chin Kuo
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Patent number: 7396520Abstract: A mod of combustion and a multi-component reactor to accomplish this mode of combustion are disclosed which produces fullerenes and fullerenic material by combustion. This mode consists of de-coupling an oxidation region of a flame from a post-flame region, thus giving greater control over operating parameters, such as equivalence ratio, temperature, and pressure; allows conditions of the operating parameters of the combustion reaction to be attained which would not be easily attained by conventional methods; and offers the ability to more easily stabilize the combustion reactions to allow for higher throughputs of fuel and oxidant. Several embodiments of a primary zone of a multicomponent reactor are also disclosed. Said primary zone serves as the oxidation region, operates on the principle of providing recycle to the reacting combustion mixture, and which may be operated as approximately a well-mixed reactor.Type: GrantFiled: August 31, 2002Date of Patent: July 8, 2008Assignee: Nano-C, Inc.Inventors: Jack B. Howard, David F. Kronholm, Anthony J. Modestino, Henning Richter
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Patent number: 7396521Abstract: A heat transfer fluid with hetero-nanocapsules. The heat transfer fluid comprises a fluid and a plurality of hetero-nanocapsules, uniformly dispersed in the fluid, in an amount of 0.01 to 10 parts by weight, based on 100 parts by weight of the heat transfer fluid. Since the hetero-nanocapsules are apt to disperse in fluid and have superior thermal conductivity, the heat conduction capability of the heat transfer fluid therewith is enhanced.Type: GrantFiled: July 5, 2006Date of Patent: July 8, 2008Assignee: Industrial Technology Research InstituteInventor: Gan-Lin Hwang
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Patent number: 7396522Abstract: The present invention relates to a catalyst useful for removal of hydrogen sulphide from gas streams and its conversion to sulphur, a process for preparing such catalyst and a method for removing of hydrogen sulphide using said catalyst.Type: GrantFiled: December 5, 2003Date of Patent: July 8, 2008Inventors: Jayalekshmy Ayyer, Pradipkumar Maheshchandra Shah, Virendra Bhikhabhai Patel
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Patent number: 7396523Abstract: The present invention provides radioactive metal heterocomplexes of formula (I): [(Me?N—R)L1L2]+Z (I), wherein Me, R, L1 L2 and Z? have the meanings indicated in the description. The complexes include a trivalent radioactive metal-imido group, typically a technetium- or rhenium-imido group, strongly stabilized by the presence of an ancillary tridentate hetero-diphosphine ligand L1, which allows the formation of substitution-inert [(Me?N—R)L1] moieties. Such moieties are fixed in an intermediate [(Me?N—R)Y2L1)]+ compound which contains two labile, cispositioned, Y ligands, where Y is preferably an halide group. The latter are easily replaced by a bidentate ligand L2 to give the final [(Me?N—R)L1L2]+Z? heterocomplexes. The complexes of the invention are useful for the preparation of radiopharmaceuticals: in fact, a bioactive fragment which confers biological target-seeking properties can be introduced either on the L2 framework or the imido R group.Type: GrantFiled: October 31, 2003Date of Patent: July 8, 2008Assignee: Bracco Imaging S.p.A.Inventors: Francesco Tisato, Cristina Bolzati, Marina Porchia, Fiorenzo Refosco
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Patent number: 7396524Abstract: Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (?) of ICa,L recovery in tissue expressing the L-type calcium channel or any subunit or combination thereof of the L-type calcium channel treated with a test compound to the ventricular repolarization time of cardiac tissue treated with a test compound. The methods further comprise determining an arrhythmic risk score for a specified dose of a test compound.Type: GrantFiled: August 2, 2005Date of Patent: July 8, 2008Assignee: Main Line Health Heart CenterInventor: Gan-Xin Yan
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Patent number: 7396525Abstract: A regime/regimen (and compositions therefor) for inducing and/or stimulating the growth of keratinous fibers and/or slowing the loss and/or increasing the density thereof, notably human hair and/or eyelashes, entails administering to a mammalian subject in need of such treatment, for such period of time as required to elicit the desired effect, a thus effective amount of at least one 2-alkylideneaminooxyacetamide compound having the formula (I):Type: GrantFiled: July 15, 2005Date of Patent: July 8, 2008Assignee: L'OrealInventors: Roger Rozot, Christophe Boulle, Maria Dalko
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Patent number: 7396526Abstract: There are provided compositions which include a retinoid and preferably retinal; a dermatologically active acid; and a volatile base, such as ammonium hydroxide. Another embodiment of the invention includes compositions comprising a retinoid and preferably retinal; a dermatologically active acid; a volatile base; and a second neutralizing agent. There are also provided compositions which include a retinoid, a neutralized ammonium salt of a dermatologically active acid, and optionally a neutralized salt, other than ammonium salt, of an acid. Further provided are methods for reducing fine lines, wrinkles, skin roughness, and pore size and for increasing the clarity of a skin surface, cellular turnover, skin radiance, skin smoothness, skin permeation or collagen synthesis in a mammal in need thereof. Compositions as described above are administered topically to the skin of the animal.Type: GrantFiled: May 5, 2000Date of Patent: July 8, 2008Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Curtis A. Cole, Laura E. Flack, Claudia Kaminski, Victoria Van Leeuwen, Elvin R. Lukenbach
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Patent number: 7396527Abstract: Polymers (i.e. polyesters, polyamides, polythioesters, polyanhydrides, or a mixture thereof) which degrade hydrolytically to provide a combination of a beta-lactam antibiotic (e.g., amoxicillin) and a beta-lactamase inhibitor (e.g., clavulanic acid) (or a pharmaceutically acceptable salt thereof) are provided. Methods of producing these polymers, intermediates useful for preparing these polymers, and methods of using these polymers to deliver a combination of a beta-lactam antibiotic and a beta-lactamase inhibitor (or a pharmaceutically acceptable salt thereof) to a host are also provided.Type: GrantFiled: August 6, 2004Date of Patent: July 8, 2008Assignee: Rutgers, The State University of New JerseyInventor: Kathryn E. Uhrich
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Patent number: 7396528Abstract: The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and allo-transplantation utilising the modified corneal tissue. The method of modifying cells of corneal tissue to express an active agent involves exposing harvested corneal tissue to an effective concentration for transfection of an expression vector which comprises a nucleotide sequence encoding for the active agent for a period sufficient to allow infection, such that cells of the corneal tissue will express the active agent.Type: GrantFiled: January 30, 2006Date of Patent: July 8, 2008Inventors: Keryn Anne Williams, Douglas John Coster, Sonja Klebe
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Patent number: 7396529Abstract: The invention relates to isolated complexes comprising one or more galectin associated with Mgat5 modified glycan or polylactosamine modified glycan, and isolated lectin-Mgt5 modified glycan lattice comprising an array of multivalent interactions among lectins, Mgat5 modified glycans, polylactosamine modified glycans, and/or glycoproteins. Methods for evaluating a test compound for its ability to regulate receptor clustering through glycans on cell surfaces; and methods for regulating receptor clustering on cell surfaces comprising altering glycans on the cell surface associated with receptor clustering are also discovered.Type: GrantFiled: January 11, 2002Date of Patent: July 8, 2008Assignee: Mount Sinai HospitalInventors: Jim Dennis, Michael Demetriou
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Patent number: 7396530Abstract: The invention provides a method of alleviating a granuloma annulare or a sarcoid disease by administering to a patient having the disease, a therapeutically effective amount of an LFA-1 antagonist.Type: GrantFiled: June 8, 2005Date of Patent: July 8, 2008Assignee: Genentech, Inc.Inventor: Bernard S. Goffe
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Patent number: 7396531Abstract: The present invention relates to the use of selected polypeptides from African Swine virus for the prevention and therapy of African Swine infections as well as other infections, including immune deficiencies in mammals and humans.Type: GrantFiled: July 5, 2006Date of Patent: July 8, 2008Inventors: Matthias Rath, Aleksandra Niedzwiecki
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Patent number: 7396532Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: GrantFiled: September 21, 2006Date of Patent: July 8, 2008Assignee: Sanofi Pasteur LimitedInventors: Lynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Eric Houseweart
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Patent number: 7396533Abstract: DNAs are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.Type: GrantFiled: July 28, 2003Date of Patent: July 8, 2008Assignee: Genentech, Inc.Inventors: Arnold J. Levine, Diane Pennica
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Patent number: 7396534Abstract: Disclosed are extracts of Nigrospora sphaerica as cosmetic skin benefit agents, preferably as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle. The inventive extracts, compositions and methods have effective skin lightening properties, may be easier to deliver to the skin, and are commercially available or cost-effective and available in nature.Type: GrantFiled: May 11, 2004Date of Patent: July 8, 2008Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: John Steven Bajor, Michael James Barratt, Carol Annette Bosko
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Patent number: 7396535Abstract: Methods for treating a head banging disorder by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin.Type: GrantFiled: April 25, 2003Date of Patent: July 8, 2008Inventor: Alan H. Ackerman
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Patent number: 7396536Abstract: The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised against such cuticlin proteins; and compounds that inhibit parasitic helminth cuticlin activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.Type: GrantFiled: June 9, 2004Date of Patent: July 8, 2008Assignee: Heska CorporationInventors: Ramaswamy Chandrashekar, Tony H. Morales
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Patent number: 7396537Abstract: A patch for cardiac tissue engineering includes a gel layer supported by an intermediate layer, which is attached to a reinforcement layer. These patches may be implanted in a heart to treat pediatric congenital malformations of the heart as well as adult ischemic myopathies. The gel layer may include cells such as, for example, stem cells; the intermediate layer may be biodegradable porous mesh and the reinforcement layer may be polytetrafluoroethylene. Included are methods for making patches according to the invention and for tissue engineering using patches of the invention.Type: GrantFiled: February 28, 2003Date of Patent: July 8, 2008Assignee: The Trustees of the University of PennsylvaniaInventors: Alexander Krupnick, Daniel Kreisel, Bruce R. Rosengard
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Patent number: 7396538Abstract: The present invention is an apparatus and a method for delivery of mitomycin through an eluting biocompatible implantable medical device. A biocompatible drug release matrix comprises a biocompatible drug release matrix and a drug incorporated into the biocompatible drug release matrix. The drug has antibiotic and anti-proliferative properties and is an analogue related to the quinone-containing alkylating agents of a mitomycin family. The drug is initially released from the biocompatible drug release matrix at a faster rate followed by a release at a slower rate. The drug release rate maintains tissue level concentrations of the drug for at least two weeks after implantation of the medical device. The present invention provides a coating for a vascular prosthesis that elutes the drug at a controlled rate to inhibit proliferation of smooth muscle cells causing restenosis.Type: GrantFiled: September 26, 2003Date of Patent: July 8, 2008Assignee: Endovascular Devices, Inc.Inventors: Juan F. Granada, Simon M. Furnish