Abstract: The present invention is a method of preparing affinity ligands, which method comprises to provide a cyclic scaffold comprising a thiol group, a carbonyl group and an amine group; to derivatize the amine group of said scaffold with an electrophile that carries either a functionality capable of affinity interaction or a functionality capable of a second interaction with a target molecule; and to open up the derivatized scaffold and add an amine that carries either a functionality capable of a second interaction or a functionality capable of affinity interaction with a target molecule. The method provides provide affinity ligands, which are capable of affinity interaction as well as a second kind of interaction.

Abstract: Systems, methods, and apparatus for desalinating water are provided. A vessel includes a water intake system, a reverse osmosis system, a concentrate discharge system, a permeate transfer system, a power source, and a control system. The concentrate discharge system includes a plurality of concentrate discharge ports.

Abstract: Present invention deals with cost-effective surface-modified zeolite materials developed from commercial zeolites and flyash-based zeolites by treating with surface modifiers like hexadecyltrimethyl ammonium bromide (HDTMA-Br). The formation of zeolitic materials with anionic characteristics requires treatment with a surfactant with initial concentrations greater than its critical micelle concentration (CMC). The sorption of oxyanions on the surfactant-modified zeolite (SMZ) is attributed to surface complexation and surface precipitation. Incorporation of metal ions on SMZ showed improved anion uptake for dearsenification of water due to synergistic effects and is able to meet the stringent target of 10 ppb of As on potable water being adopted by most countries. High selectivity, faster kinetics and high adsorption capacity ensures cost effectiveness of this product as compared to other low-cost products for dearsenification.

Abstract: Pollutants, such as heavy metals, phosphorus, and pathogenic organisms, are removed from water by adding a chemical coagulant to water within an enclosure. With mixing, coagulation and flocculation occur, and a floc containing the pollutant settles to the enclosure bottom; so the treated water above the floc is free from at least some of the pollutant. Some of the treated water is removed from the enclosure, and new water is added. The new water and the settled floc are mixed to resuspend floc components. The process is repeated until the floc no longer exhibits contaminant-removal capability. In an alternate system, a matrix element is deployed within the enclosure, which captures a portion of the floc that settles within the water column. Pollutants in new water added to the enclosure encounter these suspended floc particles and are subsequently removed from the water.

Abstract: A wastewater separation system for separating an aqueous phase from an organic phase comprising oil, fat and/or grease in wastewater is disclosed. The wastewater may be collected from restaurant grease traps, as well as other food preparation facilities, schools, hospitals, processing plants and the like. A separator, such as a centrifugal separation device, comprises a wastewater inlet, an organic phase outlet for discharging low density liquid and solids and an aqueous phase outlet for discharging water and possibly other high density liquids and solids. The system can be portable and can be mounted on a vehicle for collection and treatment at various sites. Heat can be introduced to the system to accelerate the separation of the aqueous phase from the organic phase of the wastewater.

Abstract: A contaminant-flushing machine for removing contaminants from a container, such as an engine transmission, air-conditioner coil, or transmission cooler, which includes hoses for coupling to the transmission cooler and a pump for circulating fluid through the hoses and the transmission cooler, and a fluid filter having a reduced tendency towards causing vaporization of the fluid. Also included in the contaminant-flushing machine is an automatic aeration system for injecting air into the circulating fluid at predetermined intervals. Additionally, a reverse flow piping circuit is included to permit automatic and electric manipulation of the flow direction of fluid through said transmission cooler while at the same time not altering the direction of flow of fluid through the pump. The flow reversals are repeated with a cycle of three (3) seconds in one direction followed by a flow in the other direction of one-fourth (¼) of a second, thereby creating an overall flow of fluid primarily in one reverse direction.

Abstract: Disclosed is a method for manufacturing a conductive organic thin film device. An air-bridge type of an upper electrode is formed over a lower electrode by using a sacrificial layer and then a gap having a thickness of several nano meter is formed in a part at which the upper electrode and the lower electrode intersect by removing the sacrificial layer. The conductive organic molecules are uniformly adsorbed between the upper electrode and the lower electrode of the nano gap. Adsorption extent of the conductive organic molecules is confirmed by observing a current flowing through the upper and lower electrodes when the conductive organic molecules are adsorbed. Thus, reproducibility of a manufacturing process is improved and mass production is facilitated by adoption of a standardized process.

Abstract: Fabrication apparatus and methods are disclosed for shaping and finishing difficult materials with no subsurface damage. The apparatus and methods use an atmospheric pressure mixed gas plasma discharge as a sub-aperture polisher of, for example, fused silica and single crystal silicon, silicon carbide and other materials. In one example, workpiece material is removed at the atomic level through reaction with fluorine atoms. In this example, these reactive species are produced by a noble gas plasma from trace constituent fluorocarbons or other fluorine containing gases added to the host argon matrix. The products of the reaction are gas phase compounds that flow from the surface of the workpiece, exposing fresh material to the etchant without condensation and redeposition on the newly created surface. The discharge provides a stable and predictable distribution of reactive species permitting the generation of a predetermined surface by translating the plasma across the workpiece along a calculated path.

Abstract: A method for controlling a plasma in a semiconductor substrate processing chamber is provided. The method includes the steps of supplying a first RF signal to a first electrode within the processing chamber at a first frequency selected to cause plasma sheath oscillation at the first frequency; and supplying a second RF signal from the source to the first electrode at a second frequency selected to cause plasma sheath oscillation at the second frequency, wherein the second frequency is different from the first frequency by a differential equal to a desired frequency selected to cause plasma sheath oscillation at the desired frequency.

Abstract: An ion-ion plasma source, that features a processing chamber containing a large concentration of halogen or halogen-based gases. A second chamber is coupled to the processing chamber and features an electron source which produces a high energy electron beam. The high energy electron beam is injected into the processing chamber where it is shaped and confined by a means for shaping and confining the high energy electron beam. The high energy electron beam produced in the second chamber when injected into the processing chamber ionizes the halogen gas creating a dense, ion-ion plasma in the processing chamber that is continuous in time.

Abstract: A plasma processing apparatus includes a vacuum vessel, a substrate electrode for supporting a substrate, and an antenna disposed in opposition to the substrate electrode and covered with an insulating antenna cover. A first high-frequency power supplies a high-frequency power of a 30 MHz to 3 GHz frequency to the antenna, and a second high-frequency power supply supplies a high-frequency power of a 100 kHz to 20 MHz. A refrigerant supply unit is provided for supplying a refrigerant flow to the antenna, and an electrically conductive sheet is provided between the antenna and the antenna cover. The electrically conductive sheet has a surface that is parallel to the substrate electrode and is larger than an opposing surface of the antenna.

Abstract: Methods are provided for producing large volumes of small antenna arrays. In one embodiment, the method comprises the steps of creating an antenna array pattern as a computer file, printing the created pattern onto the surface of a suitable transfer paper, placing the printed image surface in contact with the surface of a material to be etched, and transferring the printed image to the surface of the material to be etched. The transfer can be effected by any combination of chemicals, heat, and/or pressure. After transfer of the printed image, the transfer paper is removed. The step of removing the transfer paper optionally includes wetting the transfer paper in a manner that dissolves the transfer paper leaving the printed antenna pattern on the surface of the material to be etched.

Abstract: A piezoelectric ceramic composition includes a bismuth layer compound containing at least Sr, Bi and Nb, e.g., (Sr0.9Nd0.1)Bi2Nb2O9, as a main component and 2 parts by weight or less (excluding 0 part by weight), preferably 0.04 part by weight to 0.5 part by weight, of Cu in terms of CuO relative to 100 parts by weight of the main component. From the viewpoint of improvement in sinterability, 0.1 part by weight to 2 parts by weight of Mn in terms of MnCO3 relative to 100 parts by weight of the main component is preferably contained. As a result, it is possible to obtain a piezoelectric ceramic composition resisting no deterioration in piezoelectricity even when a rapid temperature change occurs, and an advantageous piezoelectric component, such as a piezoelectric actuator or a piezoelectric resonator, manufactured using the piezoelectric ceramic composition.

Abstract: Free flowing filler composition based on organofunctional silane and/or mixtures of organofunctional silanes possessing mercaptan and blocked mercaptan functionality. The invention also relates to articles of manufacture, particularly tires, made from the elastomer compositions described herein.

Abstract: The inorganic scintillator of the invention is an inorganic scintillator capable of producing scintillation by radiation, which is a crystal comprising a metal oxide containing Lu, Gd, Ce and Si and belonging to space group C2/c monoclinic crystals, and which satisfies the condition specified by the following inequality (1A), wherein ALu represents the number of Lu atoms in the crystal and AGd represents the number of Gd atoms in the crystal. {ALu/(ALu+AGd)}<0.

Abstract: The invention relates to formulations comprising one or more polymers with semiconducting, charge transport, photoconducting and/or photo- or electroluminescent properties and one or more organic solvents, to their use for the preparation of electrooptical or electronic devices, including field effect transistors (FETs), electroluminescent, photovoltaic and sensor devices, in particular by ink-jet printing, and to FETs and other semiconducting or light emitting components or devices comprising the formulations.

Abstract: For mounting on a substrate by using an electroconductive adhesive, an electroconductive paste for forming an external electrode which has improved moisture resistance and which is resistant to occurrence of external-electrode peeling, as well as a ceramic electronic component including the electroconductive paste are provided. The electroconductive paste includes a base-metal electroconductive powder, first glass frit, and an organic vehicle, wherein the first glass frit has a B2O3 content of 10 to 20 percent by mole, a SiO2 content of 50 to 65 percent by mole, an alkali metal oxide content of 10 to 20 percent by mole, a ZnO content of 1 to 5 percent by mole, a TiO2 content of 1 to 5 percent by mole, a ZrO2 content of 1 to 5 percent by mole, and an Al2O3 content of 1 to 5 percent by mole.

Abstract: Dielectric fluids comprising oil fractions derived from highly paraffinic wax are provided. Further provided are processes for making these dielectric fluids comprising oil fractions derived from highly paraffinic wax. The dielectric fluids are useful as insulating and cooling mediums in new and existing power and distribution electrical apparatus, such as transformers, regulators, circuit breakers, switchgear, underground electrical cables, and attendant equipment.

Abstract: Disclosed is both a method and apparatus for controlling and measuring an embossed texture on a decorative article. The embossed textured article includes both peaks and valleys that are measured and quantified to determine a profile of the textured article. Typically, the textured article comprises both chemically and mechanically embossed areas. The method uses moving average subtraction and peak/valley determinations to eliminate web flutter that often distorts the quantification of the mechanically embossed texture. The resulting profile may then be used to control a desired embossed profile.

Abstract: A one-piece container closure with a collar, leaflets hingedly attached to the collar, and thin flexible foldable webs attached to and extending between the leaflets. The leaflets are flat with the webs folded beneath in closed closure position. The leaflets are pivoted upwardly with webs unfolded therebetween in open position. An integral cap is attached to the collar by a snap-action bow-tie hinge. A central pin on the cap seals with the leaflets when the cap is closed. The closure is integrally molded in open position with raised leaflets and unfolded webs, leaflets then being lowered and the webs folded to closed position while the closure is still warm.

Abstract: Injection molding method and apparatus for ejecting a molded plastic article from a mold. A lifting structure and/or step is provided with a lifting portion which is configured to contact substantially one half of an end of the molded plastic article along a line substantially perpendicular to the lifting direction. Since the molded plastic article is lifted by its end, the article does not have to be solidified at its interior, thus allowing earlier removal of the article from the mold, reducing cycle time. A tapered surface forms an acute angle with respect to the lifting portion to form a tight seal with the mold, preventing leakage. Preferably, the neck ring engages only an outer circumferential portion of the molded plastic article during a majority of a mold opening stroke.

Abstract: A composite material for a bipolar plate of fuel cells is comprised of conductive carbon dispersed in polybenzoxazine matrix. The present invention also provides a composite material for preparing a bipolar plate for fuel cells comprising a polymer where a volume reduction percent is less than 5%, preferably 3%, and more preferably 1% after polymerization of the monomers with respect to total volume of the monomers before the polymerization thereof, and conductive carbon. The polymers of the present invention have good workability since there is little volume change during polymerization, and good mechanical and chemical properties, and they can be manufactured at a low cost.

Abstract: The present invention provides a taphole cooling structure allowing prevention of wear and deformation of peripheral bricks of the taphole and maintaining stable operation of the furnace in high copper matte grade operations and high load operations. The taphole cooling structure is provided with a hollow jacket body to be inserted into an opening penetrated on a furnace wall, wherein a water passage is installed in the internal of the jacket body for circulating cooling water while a flange made of the same material as the furnace wall is provided on the periphery of said jacket body to be weldingly connected to the said furnace wall, wherein a refractory material is filled within a hollow of the said hollow jacket body and perforated with a taphole for draining solutions from the furnace body.

Abstract: A metallic alloy having at least two metallic constituents is produced by first furnishing at least two non-oxide compounds, wherein the non-oxide compounds collectively comprise each of the metallic constituents, and wherein each of the non-oxide compounds is soluble in a mutual solvent. The method further includes dissolving the non-oxide compounds in the mutual solvent to produce a solution containing the metallic constituents, thereafter heating the solution to remove the mutual solvent and oxidize the metallic constituents to produce a mixed metallic oxide, thereafter cooling the mixed metallic oxide to form a substantially homogeneous mixed metallic oxide solid mass, and thereafter chemically reducing the mixed metallic oxide solid mass to produce a metallic alloy. The metallic alloy may be consolidated or otherwise processed.

Abstract: A transport system is provided for a sample testing machine. The transport system includes a carrier holding a set of test sample devices and a drive subsystem for moving the carrier through the sample testing machine. The drive subsystem includes a reciprocating motor-driven block engaging the carrier and moving the carrier back and forth in a predetermined longitudinal path extending along a longitudinal axis from an entrance station to a plurality of processing stations in the sample testing machine. The processing stations are accessed as the carrier is moved along the path. The carrier includes features in the form of slots that are detected by strategically placed optical interrupt sensors. As the carrier moves, the slots are detected by the sensors to thereby continuously track the position of the carrier and the test devices as they are moved through the instrument.

Abstract: This invention relates to test element analysis system for the analytical investigation of body liquids. An evaluation instrument, pertaining to the system, comprises a storage container, where a plurality of test elements is held ready for use, a sample application position, where one test element at a time is brought into contact with the sample, a measuring device for the determination of a measurable variable characteristic for the analysis, and a transport device, by which one test element at a time is taken out of the test element storage container at the take out position and transported to the sample application position.

Abstract: A sample-conveying system has first and second conveying paths which are separated from each other. A first transition base is located at a conveyance terminal end portion of the conveying path. A second transition base is located at a conveyance starting end portion of the conveying path. A mobile unit moves between the first and second conveying paths. The transition base is provided with a receptacle carrier and a rack carrier. The receptacle carrier transfers receptacles on the conveying path to a rack on the transition base. The rack carrier transfers the rack on the transition base onto the mobile unit. The transition base is provided with a rack carrier and a receptacle carrier. The second rack carrier transfers the rack on the mobile unit onto the transition base. The second receptacle carrier transfers each receptacle held in the rack to a holder in the conveying path.

Abstract: A piercing station for piercing sample container caps or thick stoppers is provided. The cap piercing station utilizes a piercing blade having a generally Z-shaped cross-section, a carriage assembly for moving the blade to pierce a cap on a container, an alignment block assembly for preventing the container from being lifted up by friction with the blade when the blade is being withdrawn from a pierced cap, and a latch assembly for latching the alignment block assembly when the blade is being withdrawn.

Abstract: The invention relates to a particle injector for introducing particles into a carrier flow of a microfluidic system, especially for injecting biological cells into the carrier flow of a cell sorter. The particle injector includes an inlet for receiving the carrier flow, an outlet for discharging the carrier flow including the introduced particles, a carrier flow channel which connects the inlet to the outlet, and an injection channel flowing into the carrier flow channel for introducing the particles into the carrier flow. The inventive particle injector is characterized in that the carrier flow channel has substantially no dead volume.

Abstract: For the purpose of obtaining medical preparations by means of a printing technique, a specimen cylinder is provided with a syringe cone segment that can be separated from a cylinder segment. After the syringe cone segment has been removed, a filtering device with a filter which is held so as to be sealed relative to the inner wall of the specimen cylinder projects beyond its holder and beyond the cylinder segment in an operational position of the filtering device and can be pressed onto a specimen carrier in a simple manner.

Abstract: Method and device to simultaneously detect different antibodies and antigens via immunoenzimatic tests and ELISA (Enzyme Linked ImmunoSorbent Assay) constituted by small absorbent cylinders, on which the immunocomplexes are formed, blocked at a modular distance on a probe; that carries a label to identify the sample under examination.

Abstract: A stack type reactor that can adjust a length of channel (reaction time) to react raw substances with each other for a sufficient time and mix completely raw substances to maximize the reaction efficiency. The stack type reactor comprises an upper block with at least two inlets that introduce different kinds of raw substances and a lower channel fluidly connected to the inlets and formed at a lower surface thereof; a unit block including an upper channel corresponding to the lower channel of the upper block and formed on an upper surface thereof, the unit block including a lower channel formed at a lower surface thereof and fluidly connected with the upper channel via a connecting flow passage. The upper block and unit block form a flow path for the raw substances by connecting to the lower channel of the upper block to the upper channel of the unit block.

Abstract: The invention provides a method and apparatus for introducing a high-density hydrocarbon liquid into a hydrocracking reactor. The method comprises atomizing the high-density hydrocarbon liquid and injecting the atomized liquid into the hydrocracking reactor. The method may also comprise mixing hydrogen with the high-density hydrocarbon liquid prior to atomizing the high-density hydrocarbon liquid. The apparatus comprises an injection valve for introducing a high-density hydrocarbon liquid into a hydrocracking reactor comprises an atomizer coupled to receive the high-density hydrocarbon liquid. The atomizer comprises a nozzle configured to atomize the high-density hydrocarbon liquid and inject the high-density hydrocarbon liquid into the hydrocracking reactor. The injection valve may also comprise a mixer coupled to receive hydrogen and the high-density hydrocarbon liquid. The mixer may be configured to mix the hydrogen and high-density hydrocarbon liquid and deliver the mixture to the atomizer.

Abstract: A crystallization system is provided comprising a trial generation station configured to generate crystallization trials in trial zones of a crystallization plate; an imaging station configured to take images of crystallization trials in the crystallization plate; a transport mechanism configured to transport the crystallization plate to the imaging station after generation of the crystallization trials; and a controller including logic for causing the trial generation station to generate the crystallization trials in the crystallization plate, logic for causing the transport mechanism to transport the crystallization plate to the imaging station and logic for causing the imaging station to take images of the crystallization trials.

Abstract: The present invention provides a method for improving the recovery of cesium-131 (Cs-131) from barium (Ba) carbonate. Uses of the Cs-131 purified by the method include cancer research and treatment, such as for the use in brachytherapy. Cesium-131 is particularly useful in the treatment of faster growing tumors.

Abstract: A method for hydride gas purification uses materials having at least one lanthanide metal or lanthanide metal oxide. The method reduces contaminants to less than 100 parts per billion (ppb), preferably 10 ppb, more preferably 1 ppb. The material can also include transition metals and transition metal oxides, rare earth elements and other metal oxides. The invention also includes materials for use in the method of the invention.

Abstract: Process for the production of a metal oxide powder having a BET surface area of at least 20 m2/g by reacting an aerosol with oxygen in a reaction space at a reaction temperature of more than 700° C. and then separating the resulting powder from gaseous substances in the reaction space, wherein the aerosol is obtained by atomisation using a multi-component nozzle of at least one starting material, as such in liquid form or in solution, and at least one atomising gas, the volume-related mean drop diameter D30 of the aerosol is from 30 to 100 ?m and the number of aerosol drops larger than 100 ?m is up to 10%, based on the total number of drops, and metal oxide powder obtainable by this process.

Abstract: The present invention relates to an environmentally benign process for the simultaneous preparation of nanocrystalline anatase titanium dioxide and hydrazine mohydrochloride, in substantial amounts from the acidic aqueous titanium tetrachloride solution by reacting with hydrazine monohydrate at ambient conditions of temperature and pressure. The process of the present invention is simple, easy to operate, pollution free, high in product purity and homogeneous in product particle.

Abstract: This invention relates generally to forming a patterned array of fullerene nanotubes. In one embodiment, a nanoscale array of microwells is provided on a substrate; a metal catalyst is deposited in each microwells; and a stream of hydrocarbon or CO feedstock gas is directed at the substrate under conditions that effect growth of fullerene nanotubes from each microwell.

Abstract: A method and apparatus for the production of hydrogen-rich gas are provided. The method and apparatus prevent over-reduction of iron oxide-based shift catalyst by introducing an oxidative stream along with a carbon monoxide containing gaseous feed stream from a catalytic steam reformer to the catalyst bed region and thereby limits structural deterioration of the catalyst. Various sources may provide the oxidative stream including a shift catalyst bed region and a selective oxidation catalyst region.

Abstract: The present invention relates to new crystalline molecular sieve SSZ-74 prepared using a hexamethylene-1,6-bis-(N-methyl-N-pyrrolidinium) dication as a structure-directing agent, and methods for synthesizing SSZ-74.

Abstract: The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent induces of a range of immune responses.

Abstract: Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then sti

Abstract: Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.

Abstract: An aerosol-based insecticide composition comprising an active ingredient, such as deltamethrin, and a suitable carrier is disclosed as well as a method for its use. The insecticide composition may optionally contain one or more surfactants. Deltamethrin is preferably used as the active ingredient in the insecticide composition because of its tolerance for use on food. Furthermore, it has also been determined that deltamethrin is non-repellant to termites.

Abstract: The present invention relates to the delivery of nonsteroidal antiinflammatory drugs (NSAIDs) through an inhalation route. Specifically, it relates to aerosols containing NSAIDs that are used in inhalation therapy. In a method aspect of the present invention, an NSAID is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of an NSAID, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particle having less than 5% NSAID degradation products. In a kit aspect of the present invention, a kit for delivering an NSAID through an inhalation route is provided which comprises: a) a coating of an NSAID composition and b) a device for dispensing said coating as a condensation aerosol.

Abstract: Topically applicable cosmetic compositions useful for the UV-A photoprotection of the skin and/or hair contain thus effective amounts of at least one silane, siloxane or polysiloxane merocyanine sulfone having at least one of the structural formulae (1), (2) and (3) below:

Abstract: This invention concerns cosmetic compositions and methods involving 4-hydroxy-3-methoxybenzyl alcohol as an active ingredient. This material is shown to be an extremely effective sub-lethal inhibitor of the metabolism of selected corynebacteria and to give significant deodorancy benefits.

Abstract: A process for permanently reshaping keratin fibers, comprising the application to the keratin fibers, before reducing and/or after the fixing, of a pre-treatment and/or post-treatment cosmetic composition comprising, in a cosmetically acceptable medium, at least one aminosilicone, as defined herein, in non-microemulsified form.

Abstract: The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane protein having a hemagglutinin activity. This viral vector showed gene transfer at a high efficiency into host cells. In particular, it was established that genes can be transferred thereby at a high efficiency into cells into which genes can hardly be transferred by the conventional techniques, for example, blood cells and hematopoietic cells including hematopoietic stem cells, and mucous cells including mucosa epithelial cells. The viral vector of the present invention is highly useful as a vector for gene therapy.