Abstract: One embodiment of the invention relates to an implant having a basic body composed of a biocorrodible material and having an active coating or filling of a cavity, consisting of or containing the components a) at least one pharmaceutically active substance; and b) an ancillary substance for improving the permeability of the at least one pharmaceutically active substance.

Abstract: This invention relates to stents having medicated multi-layer hybrid polymer coatings, useful for the treatment of stenosed vasculature or other body passages.

Abstract: There is described zeolites containing releasably adsorbed nitric oxide, methods of preparing the zeolites, methods of releasing the nitric oxide into a solution or into air and uses of the zeolites in therapy.

Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the composition, and a method of treating a disorder are provided.

Abstract: A method for the prophylaxis or treatment of restenosis comprising administering a therapeutically effective amount of Annexin A5 or a functional analogue or variant thereof to a patient in need of such treatment. A method for the treatment of stenosis in a patient comprising performing an intervention for the treatment of stenosis in conjunction with administering a therapeutically effective amount of Annexin A5 or a functional analogue or variant thereof. A pharmaceutical composition comprising a therapeutically effective amount of Annexin A5 or a functional analogue or variant thereof for the prophylaxis or treatment of restenosis. A drug eluting stent, wherein the drug is Annexin A5 or a functional analogue or variant thereof, and a method of making such a stent.

Abstract: A device for repairing a heart valve comprises a medical device (10). The medical device (10) comprises an element in order to downsize the annulus upon insertion and allow the leaflets to open and close properly. The medical device (10) provides a temporary or permanent downsizing of the heart valve. An annuloplasty implant and/or heart valve prosthesis is in embodiments releasably attached to the medical device for insertion to the annulus and permanent fixation of the latter in a desired shape.

Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.

Abstract: A device for improving the function of a heart valve comprises: a support member formed from a shape memory material, and a restraining member providing a restraining action on a course of the support member. The support member may abut one side of the valve conforming to the shape of the valve annulus upon said shape memory material assuming an activated shape while the restraining member restrains the course of the support member. The restraining action is removable for allowing the support member to assume a desired, altered course. The restraining member may be biodegradable to be degraded within a patient or may be detachable from the support member to be withdrawn. The support member according to another embodiment presents a shape change in that an increased cross-section is associated with a shortened length of the support member. The support member according to yet another embodiment has a first and a second activated shape.

Abstract: An implantable kinetic power generator has an oscillating weight that is physically coupled to a first gear. A second gear with a rotor at its center of rotation is coupled to the first gear. A generating coil is located in close proximity to the rotor. An energy storage unit is electrically coupled to the coil. A shell suitable for implantation in the eye encloses these components. When the rotor rotates, energy generated by the coil is stored in the energy storage unit.

Abstract: A fiber matrix is provided for maintaining space in soft tissue, for example for use in procedures for assisting drainage of aqueous humor from an eye to treat glaucoma. The fiber matrix comprises a plurality of crossing fibers forming a mesh with a plurality of void spaces. The fibers and void spaces are sized and arranged so as to permit passage of fluid through the fiber matrix and to inhibit formation of scar tissue through the fiber matrix. The fibers may comprise a polymeric material, and the fiber matrix may be manufactured by electrospinning. The fibers may comprise a biostable and/or a biodegradable material. In one method of using a fiber matrix, the fiber matrix is positioned under a scleral flap, with at least part of the fiber matrix under the scleral flap.

Abstract: Prosthetic devices, methods and systems are disclosed. Eye position and/or neural activity of a primate are recorded and combined. The combination signal is compared with a predetermined signal. The result of the comparison step is used to actuate the prosthetic device.

Abstract: A control system for an accommodative intraocular lens includes a sensing circuit for sensing a signal that controls a ciliary muscle of an eye and an amplifier circuit for amplifying the sensed signal. The output of the amplifier circuit is used to control an accommodative IOL. At least one electrode located in the vicinity of cranial nerve III, the ciliary ganglion, or the ciliary muscles is used to receive the signal that controls the ciliary muscles. A filter may also be included.

Abstract: An antipathogenic biomedical implant is formed throughout its structure of a matrix material comprising at least about 1 weight percent of a photocatalytically active filler which exhibits an antipathogenic effect upon irradiation with light. The photocatalytically active filler is arranged in the matrix material in the implant to receive light irradiated from an external light source. In another embodiment, an antipathogenic biomedical implant comprises at least about 1 weight percent of a photocatalytically active material which exhibits an antipathogenic effect upon irradiation with light, wherein the photocatalytically active material is arranged in the implant to receive light irradiated from an external light source.

Abstract: Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.

Abstract: Provided herein are anisotropic muscle implants that have a biodegradable scaffold comprising a plurality of fibers oriented along a longitudinal axis. The implants may include mammalian muscle cells seeded and/or fused into myotubes on the scaffold. Methods of forming the muscle implants are provided, as are methods of treating a subject in need of skeletal muscle reconstruction.

Abstract: Methods are provided for manufacturing an internal thread in a porous orthopedic implant, such as an orthopedic anchor. In one embodiment, the internal thread is formed in the orthopedic implant by bonding a pre-formed, internally threaded component to the orthopedic implant. In another embodiment, the internal thread is formed in the orthopedic implant by bonding a solid plug to the orthopedic implant or forming a surface coating on the orthopedic implant and then machining the solid plug or surface coating.

Abstract: A method for reducing prosthetic loading failure including the steps of providing a prosthesis for a vertebral column comprising at least an upper part for attachment to an upper vertebrae and a lower part for attachment to a lower vertebrae, the upper part having a lower curved surface and the lower part having an upper curved surface, wherein the upper and lower curved surfaces have a centre of radius of curvature offset rearwardly with respect to a central vertical axis through the upper and lower vertebrae, and positioning the centroid of at least one of the upper and lower parts substantially on the same vertical axis of the centre of radius of curvature.

Abstract: A bone fusion device, system, kit, and/or method can include an elongated structure including at least two anchor portions and at least one deformable segment connected on each end to one of the at least two anchor portions. Each deformable segment can include a plurality of spaced apart deformable members deformable from an unexpanded configuration to an expanded configuration. The bone fusion device may be implanted between two bone structures in the unexpanded configuration utilizing a minimally invasive surgical procedure. The deformable members can be compressed along a longitudinal axis of the device to deform the deformable members to the expanded configuration into contact with the two bone structures. A bone growth promoting material can be placed in the anchor portion lumen and in the interior of each deformable segment to promote bone in-growth between the bone structures.

Abstract: An elongate, longitudinally oriented outer sleeve includes an outer sleeve surface and has a sleeve body. A stem-receiving cavity extends from a distal sleeve end into the sleeve body. The distal sleeve end includes a sleeve interference protrusion extending from the distal sleeve end away from the sleeve body. A joint articulating member includes an elongate, longitudinally oriented stem. The joint articulating member includes a joint articulating surface spaced apart from a distal stem end by an angularly extending connector neck. When the stem is inserted into the stem-receiving cavity, the stem and the outer sleeve are configured for selective relative rotation about a shared longitudinal axis, and the connector neck impinges upon the sleeve interference protrusion responsive to a predetermined amount of relative rotation between the stem and the outer sleeve to prevent relative rotation between the stem and the outer sleeve outside a predetermined range of allowable rotation.

Abstract: An artificial functional spinal unit including an expandable intervertebral implant that can be inserted via a posterior surgical approach and used with one or more facet replacement devices to provide an anatomically correct range of motion is described. Lordotic and non-lordotic expandable, articulating implants and cages are described, along with embodiments of facet replacement devices and instruments for insertion. Methods of insertion are also described.

Abstract: A biomaterial for an artificial cartilage is disclosed. The biomaterial eliminates the risk of possible adverse effects due to scattering of fragments of the biodegradable and bioabsorbable polymers and shows enhanced adhesiveness which allows more solid adhesion of the artificial cartilage to vertebral bodies and the like. The biomaterial includes an organized structure comprising organic fibers arranged in one of a multiaxial three-dimensional woven or knitted structure having three or more axes and a combined structure of the woven structure and the knitted structure; and a biodegradable and bioabsorbable pin provided inside the organized structure.

Abstract: A radially compressed xerogel spinal nucleus implant is manufactured and utilized for implantation into an intervertebral disc space. The implant has an optimized cross-sectional ellipsoid configuration which facilitates insertion of the implant through a minimal incision in the annulus. Radial compression is achieved by exerting substantially equilateral circumferential compression on an object contained within a radially collapsible member for exerting substantially equilateral circumferential compression on the object. Radial compression may also be achieved by exerting substantially equilateral circumferential compression force on a spinal nucleus implant via gas pressure in a sealed chamber.

Abstract: Instruments and methods for inserting an intervertebral implant. Insertion of the implant is accomplished by grasping the implant between the arms of an insertion instrument having arms which separate from each other and close against each other onto the implant, such that the ends of the arms of the insertion instrument engage recesses of the implant. A spacer may be provided between the arms of the insertion instrument to help position the implant while held by the arms.

Abstract: An elongate, longitudinally oriented outer sleeve includes an outer sleeve surface defining a radially oriented proximal sleeve border, a radially oriented proximal sleeve rim intersecting the outer sleeve surface at the proximal sleeve border, an outer sleeve body enclosed by the outer sleeve surface and the proximal sleeve rim, and an elongate, longitudinally oriented stem-receiving cavity formed in the outer sleeve body and intersecting the proximal sleeve rim to define a stem-receiving aperture. A joint articulating member includes an elongate, longitudinally oriented stem, an articulating surface, and an interface rim. When the stem is at least partially inserted into the stem-receiving cavity, the proximal sleeve rim and the interface rim interact to change a longitudinal relationship between the outer sleeve and the joint articulating member responsive to relative radially-oriented rotation between the stem and the stem-receiving cavity.

Abstract: A prosthetic glenoid component for replicating the behavior of a patient's natural glenoid includes a rim that replicates the patient's natural glenoid labrum.

Abstract: Methods and apparatus for performing knee arthroplasty, including, but not limited to, bicruciate retaining knee arthroplasty, are described herein. Methods and apparatus for preparing a distal femur for a femoral implant as well as methods and apparatus for preparing a proximal tibia for a tibial implant are described. These methods and apparatus, in at least some embodiments and uses, facilitate decreasing the complexity of knee arthroplasty procedures such as bicruciate retaining procedures, while maintaining, if not improving on, the safety, accuracy and/or effectiveness of such procedures.

Abstract: Methods and apparatus of the present invention provide for orthopaedic total replacement of the hip while substantially preserving muscles and soft tissues around the hip joint resulting in reduced healing time and decreased risk of dislocation following the procedure. In an exemplary embodiment, the acetabulum is prepared and fitted with a prosthetic acetabular cup 702 and a prosthetic femoral head 1102 is fitted into the prosthetic acetabular cup 702. An intramedullary rod 1502 is inserted longitudinally into the femur. A prosthetic femoral neck 3102 is then inserted from a point along the side of the patient's body and into the side of the femur and through a pre-existing lateral bore in the intramedullary rod 1502 and through the remainder of the femur to join the prosthetic femoral head 1102. The methods and apparatus include structures and techniques for fixing the prosthetic femoral neck 3102 in relation to the intramedullary rod 1502.

Abstract: The invention relates to a prosthesis for replacing a joint connection, wherein like magnetic fields from the condyle 10, socket 12 and joint collar 14 overlap in such a way that the repulsive forces generate a suspended state of the condyle 10 in the bearing and the damping effect is maximized. The invention is also directed to a method for replacing a bone junction in a mammal, wherein the prosthesis is fastened to the articular bone and repulsive forces generate a levitated state of the condyle 10 under load.

Abstract: An implant includes a body configured to be implanted at least partially within a bone canal. The body has a proximal end, a longitudinal axis and a cavity located at the proximal end. The cavity is configured to mate with an insertion tool and defines a cavity axis that is not parallel to the longitudinal axis of the implant.

Abstract: The invention relates to a process for producing an (ultra) high molecular weight polyethylene (HMWPE) article comprising:—incorporating into the HMWPE resin a Hindered Amine Light Stabilizer (HALS) and—cross-link the (U)HMWPE during or after molding the (U)HMWPE resin.

Abstract: A method of installing a transcutaneous prosthesis which includes a first component, a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells and a third component adapted for location to extend from the skin surface and the third component having an outer surface. The outer surface of the third component has a surface energy that is lower than a surface energy of at least the first component and which is low enough to deter bacterial adhesion.

Abstract: The implant is intended for introduction into an alveolar space. It is configured as an absorbable composite body made of at least a first and a second part body. The first part body is configured as a cone, truncated cone or cylinder having a body base face. The second part body is configured as a cover membrane with a membrane face, which is larger than the body base face. The cover membrane is placed on the body base face, so it projects laterally everywhere over the body base face. The first and second part body are rigidly connected to one another in the region of the mutually adjacent body base face and membrane face.

Abstract: Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.

Abstract: Described are pharmaceutical compositions comprising phentermine, metformin, and at least one pharmaceutically acceptable carrier or excipient. Another aspect of the present invention relates to a method of treating a patient suffering from obesity or needing to lose weight, comprising the step of co-administering to said patient a therapeutically effective amount of phentermine and metformin. In certain embodiments, an aforementioned method is practiced in conjunction or tandem with a medical procedure or the use of a medical device or both.

Abstract: A device for treating obesity of a patient, the device comprising: at least one operable stretching device implantable in the patient and adapted to stretch a portion of the patient's stomach wall, and an implantable control unit for automatically controlling the operable stretching device, when the control unit and stretching device are implanted, to stretch the stomach wall portion in connection with the patient eating such that satiety is created.

Abstract: An external covering and method of making an external covering for hiding the internal endoskeleton of a mechanical (e.g.,prosthetic) device that exhibits skin-like qualities is provided. The external covering generally comprises an internal bulk layer in contact with the endoskeleton of the prosthetic device and an external skin layer disposed about the internal bulk layer. The external skin layer is comprised of a polymer composite with carbon nanotubes embedded therein. The outer surface of the skin layer has multiple cone-shaped projections that provide the external skin layer with superhydrophobicity. The carbon nanotubes are preferably vertically aligned between the inner surface and outer surface of the external skin layer in order to provide the skin layer with the ability to transmit heat. Superhydrophobic powders may optionally be used as part of the polymer composite or applied as a coating to the surface of the skin layer to enhance superhydrophobicity.

Abstract: A hollow tubulous composite structure and method for prosthetic limbs is described.

Abstract: A method, system, and computer program product containing instructions for analyzing audio input to a receiver coupled to an audio player to identify an audio event as one of a plurality of pre-determined audio event types. In response to identifying the audio event, the audio player is caused to adjust an audio output. Adjusting the audio output may include causing the audio player to pause playing audio output or to lower the volume of the audio output. The audio input to the receiver may be recorded. In response to identifying the audio event, the audio player may be caused to replay a recorded portion of the audio input. The recorded portion of the audio input may include a portion recorded prior to identifying the audio event.

Abstract: There is described method for producing a computer file for inclusion in an audio bundle of a digital cinema file in which is encoded a multi-channel vibro-kinetic signal for controlling a motion platform. The audio bundle is for being transported over a digital transport link between a D-Cinema player and a motion decoder. The method comprises: obtaining a succession of blocks of vibro-kinetic samples from a vibro-kinetic file (e.g., a KineLink file); encoding binary data which represents the samples of the multi-channel vibro-kinetic signal into a sequence of monophonic PCM samples, according to a defined structure; and building a computer file using the encoded binary data, the computer file for incorporation into the audio bundle of the digital-cinema file, the encoded binary data for being transported over the digital transport link of the D-Cinema player to a motion decoder controlling the motion platform.

Abstract: An apparatus for producing a personalized 3D object is disclosed. The apparatus, or kiosk, comprises a payment detector, a user input device and a display, an image acquisition system, calculators for calculating a 3D image, a manufacturing device and an exit for delivering the personalized 3D object to the user. The manufacturing device includes a loading device for loading blank 3D objects on a platform, which includes vertical storages and a rotatable tray disposed underneath having a slit therein for receiving the blank 3D objects. The rotatable tray is computer controlled to rotated between various operative positions for loading and unloading the 3D objects.

Abstract: A method and a device for visualizing a workpiece in a visualized model of an automated installation. In accordance with the invention, the method comprises making available a selection device to the user of the visualized model of the automated installation, visualizing the automated installation together with the workpiece and centering the workpiece in the visualized model of the automated installation, where the selection device is used by the user to preselect the workpiece.

Abstract: Method for managing material flows synchronization in a batch manufacturing process including a plurality of activities includes: representing the material flow between each of any two of the connected activities by a pegging arc, where a source activity is supplying at least a portion of an associated quantity of the material to a target activity, where the quantity represents at least a portion of an associated quantity of the material; assigning to each pegging arc an order; following the assigned order, determining, for each pegging arc a speed CT at which the target activity consumes the material, and a speed PT at which the source activity produces the material; and according to CT and PT, determining which portion of a processing time of the production of the material by the source activity is to be dedicated to which portion of a processing time of the target activity.

Abstract: A manufacturing process for automatically delivering an appropriate level of instructions to a manufacturing operator on demand based on the manufacturing operator's level of activity and performance, the particular characteristics of the product being manufactured, and the particular production environment. Responsive to receiving an order for a product, the manufacturing process identifies an authorization level assigned to an operator performing a particular manufacturing activity on a part in the product and assigns a default level of instructions to the operator based on the authorization level. The process collects and models characteristics about the manufacturing environment, performance history of the operator, and knowledge decay of the operator to determine an appropriate level of instructions to provide to the operator performing a particular manufacturing activity. The manufacturing instructions associated with the appropriate level of instructions are then provided to the operator.

Abstract: Computerized methods and apparatuses fit a pillow to an individual based on the characteristics of the individual. A computerized pillow-fitting apparatus has a processor, an input device configured to input a plurality of parameters corresponding to an individual's characteristics; a determination unit which uses the processor to determine, in response to the input of the plurality of parameters, a pillow identifier based on the plurality of parameters; and an output device configured to output the pillow identifier and configured to cause a pillow to be produced based on the pillow identifier.

Abstract: A system for facilitating seasoning a plasma processing chamber. The system includes a computer-readable medium storing a chamber seasoning program (or CS program). The CS program includes code for receiving a first plurality of values and a second plurality of values of a set of parameters related to operation of the plasma processing chamber. The CS program includes code for ascertaining, using the first plurality of values and the second plurality of values, whether current values of the parameters have stabilized. The CS program also includes code for determining, using the second plurality of values but not the first plurality of values, whether the current values of parameters have stabilized within a predetermined range. The system may also include circuit hardware for performing one or more tasks associated with the CS program.

Abstract: An arrangement for implementing an automatic in-situ process control scheme during execution of a recipe is provided. The arrangement includes control-loop sensors configured at least for collecting a first set of sensor data to facilitate monitoring set points during the recipe execution, wherein the control-loop sensors being part of a process control loop. The arrangement also includes independent sensors configured at least for collecting a second set of sensor data, which is not part of the process control loop. The arrangement yet also includes a hub configured for at least receiving at least one of the first set of sensor data and the second set of sensor data. The arrangement yet further includes an analysis computer communicably coupled with the hub and configured for performing analysis of at least one of the first set of sensor data and the second set of sensor data.

Abstract: A process-level troubleshooting architecture (PLTA) configured to facilitate substrate processing in a plasma processing system is provided. The architecture includes a process module controller. The architecture also includes a plurality of sensors, wherein each sensor of the plurality of sensors communicates with the process module controller to collect sensed data about one or more process parameters. The architecture further includes a process-module-level analysis server, wherein the process-module-level analysis server communicates directly with the plurality of sensors and the process module controller. The process-module-level analysis server is configured for receiving data, wherein the data include at least one of the sensed data from the plurality of sensors and process module and chamber data from the process module controller.

Abstract: A method for predicting etch rate uniformity for qualifying health status of a processing chamber during substrate processing of substrates is provided. The method includes executing a recipe and receiving processing data from a first set of sensors. The method further includes analyzing the processing data utilizing a subsystem health check predictive model to determine calculated data, which includes at least one of etch rate data and uniformity data. The subsystem health check predictive model is constructed by correlating measurement data from a set of film substrates with processing data collected during analogous processing of a set of non-film substrates. The method yet also includes performing a comparison of the calculated data against a set of control limits as defined by the subsystem health check predictive model. The method yet further includes generating a warning if the calculated data is outside of the set of control limits.

Abstract: A method for detecting an in-situ fast transient event within a processing chamber during substrate processing is provided. The method includes a set of sensors comparing a data set to a set of criteria (in-situ fast transient events) to determine if the first data set includes a potential in-situ fast transient event. If the first data set includes the potential in-situ fast transient event, the method also includes saving an electrical signature that occurs in a time period during which the potential in-situ fast transient event occurs. The method further includes comparing the electrical signature against a set of stored arc signatures. If a match is determined, the method yet also includes classifying the electrical signature as a first in-situ fast transient event and determining a severity level for the first in-situ fast transient event based on a predefined set of threshold ranges.

Abstract: A control device for a cooling track for cooling a rolling product accepts at least partially characteristic information for a starting enthalpy value. The control device (8) determines a refrigerant volume progression (K) such that a heat volume corresponding to the difference between the starting enthalpy value (EA) and a prespecified end enthalpy value (EE) is removed from a rolling product segment (12) of the rolling product (5) during the movement of said rolling product through the cooling track (1). The control device (8) determines the refrigerant volume progression (K) independently of whether a prespecified end temperature value (TE) assigned to the end enthalpy value (EE) is reached at the end of application of refrigerant (6) to the rolling product (5). The control device (8) applies refrigerant (6) to the rolling product segment (12) during its passage through the cooling track (1) according to the determined refrigerant volume progression (K).