Abstract: Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.

Abstract: The present disclosure generally provides a multiple balloon assembly used as part of the distal region of a medical device that is capable of delivering a therapeutic agent into a body vessel having bodily fluid. The multiple balloon assembly comprises an inner balloon and an outer balloon. The outer balloon further comprises a proximal taper region, a middle region, and a distal taper region. The inflation of the inner balloon causes the middle region of the outer balloon to contact the inner wall of the body vessel, thereby, occluding the flow of fluid through the body vessel. The proximal taper region and the distal taper region are configured such that they do not touch the inner wall of the body vessel. One of the distal taper and proximal taper regions has a plurality of apertures configured to allow for the therapeutic agent to be delivered into the body vessel at a predetermined rate.

Abstract: The present invention provides a needle suitable for performing ophthalmic surgical procedures. The needle includes a flexible curved tube and an adapter which can attach the needle to a syringe for delivering anesthetic. The flexible curved tube may be of plastic, particularly PTFE, and is typically attached to the adapter by a connector. Employing a needle with a flexible curved tube significantly reduces the risk of trauma of a patient s eye during an ophthalmic surgical procedure such as a sub-Tenon s block procedure.

Abstract: This invention relates to photodynamic therapy (PDT), more specifically PDT for atherosclerotic plaque via delivering PDT-loaded nanoparticles such as liposomes, polymersomes, micelles and polymeric nanoparticles into the diseased vascular tissue. This invention provides method and formulations for delivering multiple drugs and delivering drugs to specific targeted site.

Abstract: A compliant surgical device such as a flexible entry guide employs tendons to operate or steer the device and attaches asymmetric or constant force spring systems to control tension in the tendons. As a result, the surgical device can be compliant and respond to external forces during a surgical procedure without rapidly springing back or otherwise causing a reaction that damages tissue.

Abstract: A catheter assembly (1), including an outer catheter (2) and an inner catheter (6) capable of being inserted into the outer catheter (2). The catheter assembly is characterized in that an outer catheter hub (5) and an inner catheter hub (9) are fixedly fitted to each other so that the two catheters are not rotated nor moved relative to each other, and when fitted to each other, at least a part of the tip of the inner catheter (6) is protruded by 10 mm or shorter from the tip of the outer catheter (2). When the inner catheter is inserted into the outer catheter, operabilities such as kink resistance, press-in performance, and torque transmission performance are excellent and the inner diameter thereof is increased when the catheter is used after indwelling. As a result, the range of choices of a catheter for treatment can be increased.

Abstract: A multi-component connector apparatus having a base component, an intermediate component and an end member are assembled end to end by rotational engagement. An elastic sheath extends over and covers portions of the base member, the intermediate member and the end member in a manner that precludes inadvertent decoupling of these assembled components. The sheath also prevents contamination of the assembled components after sterilization.

Abstract: A proximally trimmable catheter is disclosed. In one embodiment, the catheter includes a multi-lumen catheter tube, one or more extension tubes, and a hub for fluidly connecting the two. In a first unlocked state, the hub is axially slidable along the catheter tube. The hub includes tube pins that are in fluid communication with the extension tubes. A cutting member is positioned to longitudinally cut the catheter tube during axial sliding of the hub along the catheter tube such that distal portions of the tube pins remain disposed within the lumens of the catheter tube. When positioned as desired, the hub is locked into a second locked state and is no longer axially slidable along the catheter tube. The tube pins are fluidly sealed within the lumens of the catheter tube as to establish fluid communication between the extension tubes and the lumens via the tube pins.

Abstract: An infusion medium delivery system, device and method for delivering an infusion medium to a patient-user, includes a needle inserter device and method for inserting a needle and/or cannula into a patient-user to convey the infusion medium to the patient-user. The needle inserter device and method operate to insert a needle and cannula into a patient-user's skin and automatically withdraw the needle from the patient-user, leaving the cannula in place and in fluid flow communication with a reservoir. The delivery device may include a base portion and a durable portion connectable to the base portion, and wherein the base portion can be separated from the durable portion and disposed of after one or more specified number of uses. The base portion supports the reservoir and the needle inserter device, while the durable portion supports a drive device for selectively driving the infusion medium out of the reservoir and into the needle and/or cannula.

Abstract: A urinary catheter with an improved retaining and activating feature is provided which is a safe device with reduced irritation and discomfort to a patient. The retaining mechanism positioned at the proximal end of the catheter assumes a “close” state for introduction and removal of the catheter into and from the urethral tract, and is transitioned into the “open” state when the catheter is in the bladder by mechanically manipulating the retaining mechanism through the activation mechanism. An actuating linkage wire connected between the retaining mechanism and activation mechanism controllably reciprocates in the channel of the catheter to transition the catheter between the “open” and “closed” states.

Abstract: An infusion device having a housing with a reusable control portion and an expendable reservoir portion includes a precise drive for an infusion pump. The drive includes a piezoelectric bender assembly, a limiter and at least one contact stop. The piezoelectric bender assembly includes a cantilevered piezoelectric bender having an member of predetermined thickness fixed to move with the second end. A limiter of dimensionally stable material including a gap and at least a first mounting hole extending to the gap. The member of predetermined thickness extends into the gap. A first contact stop is positioned in the gap to define a critical gap distance limiting movement of the member of predetermined thickness in the gap. A base has a mounting surface, a port through the base and extending to the mounting surface. The port includes a first length having a smaller diameter at the mounting surface and a second length displaced from the mounting surface and having a larger diameter.

Abstract: The invention relates to a method and an electronic pill (20) for the administration of at least one drug (3) to a patient, wherein the delivery profile of the drug is determined according to at least one individual parameter of the patient. The individual parameter may particularly relate to the genotype (GEN) or phenotype of the patient and for example comprise the distribution of proteins in the gastrointestinal tract (GIT). Optionally, the individual parameter may be adjusted based on measurements by the electronic pill or external devices during its passage through the gastrointestinal tract.

Abstract: The invention relates to a hand-held medical instrument, in particular a hand-held surgical or dental instrument, comprising a component that generates mechanical vibrations during operation, and a particle damping element which has at least one hollow space that is designed to receive the mechanical vibrations and is filled at least in part with a plurality of granular particles which dampen the mechanical vibrations by means of dissipative shocks between the granular particles and/or between the granular particles and a wall surrounding the hollow space.

Abstract: System and method of photoaltering a material. The system includes a laser source operable to produce a primary pulsed beam, a holographic optical element configured to receive the primary pulsed beam and transmit a plurality of secondary beams, and a scanner operable to direct the secondary beams to the material. The secondary beams are based on the primary pulsed beam. The method includes phase shifting a pulsed laser beam to produce an input beam, holographically altering the input beam to produce a plurality of transmission beams, and scanning a portion of the material with the transmission beams.

Abstract: A treatment device for the surgical correction of hyperopia in the eye comprising a laser device controlled by a control device. The laser device separating corneal tissue by applying laser radiation. The control device controls the laser device for emitting the laser radiation into the cornea such that a lenticule-shaped volume is isolated. Removal thereof effects the desired correction. The control device (12) predefines the volume such that a posterior surface and an anterior surface are connected via an edge surface that has a width in projection along the visual axis that is wider than the one which a straight line in the same projection, that is perpendicular at the edge of the posterior or the anterior surface would have relative to the associated surface and connects the anterior surface to the posterior surface or to the perceived extension thereof.

Abstract: A treatment apparatus for operatively correcting myopia or hyperopia in an eye includes a laser device controlled by a control device and that separates the corneal tissue by applying a laser beam. The control device controls the laser device to emit the laser beam into the cornea such that a lenticule-shaped volume is isolated in the cornea. The control device, when controlling the laser device, predefines the lenticule-shaped volume such that the volume has a minimum thickness of between 5 and 50 ?m. For myopia correction, the minimum thickness occurs on the edge of the volume, and for hyperopia correction the minimum thickness occurs in the region of the visual axis.

Abstract: Techniques for the treatment of skin segments by application of optical radiation are limited due to dark skin pigmentation. The application of a whitening substance is utilized to temporarily lighten a targeted skin segment. In the temporarily lightened state, optical radiation for skin treatment is applied in a more effective manner.

Abstract: A method and apparatus for monitoring and controlling interventional therapy is described, where the interventional therapy results in the destruction of tissue and the release of chemical markers. When interventional therapy results in destruction of a patient tissue, such as cancerous tissue, a variety of chemical markers may be released into the bloodstream. An in-vitro diagnostic (IVD) device may be used to measure the concentration of an analyte representing a marker and compare the measured concentration with a predetermined set point so as to monitor or control the procedure. The blood for the analysis may be obtained either inter-procedurally or intra-procedurally depending on the promptness of the effect being measured and the speed of measurement.

Abstract: An ablation probe fixation apparatus for securing an ablation probe to tissue is disclosed. The ablation probe fixation apparatus includes a base having a top surface and a skin-contacting bottom surface, wherein the base includes an adhesive layer disposed on the skin-contacting bottom surface. The fixation apparatus also includes a fixation member coupled to the top surface of the base. The base and the fixation member include an aperture defined therein for insertion of the ablation probe therethrough.

Abstract: A return electrode detection and monitoring system and method thereof are provided. The system and method of the present disclosure provide for a combined universal recognition feature, that is to identify whether a return or neutral electrode coupled to an electrosurgical generator is a capacitive electrode or a split or non-split (solid) resistive electrode. Furthermore, the system and method will monitor both capacitive and resistive return electrodes when the electrosurgical generator is operating in the 4 Mhz range to notify an operator when the return electrode is not coupled enough which would effect power delivery to the patient and hence effect on the targeted tissue.

Abstract: A medical coagulation instrument having a shaft as well as at least one electrode tip that extends beyond the distal end of the shaft. To create a coagulation instrument whose electrodes are of simple structure and ensure an atraumatic and safe handling, at least one electrode tip should be widened or be configured as widening in the distal direction.

Abstract: A bipolar coagulation forceps with a fixed forceps leg, a pivot support, and a pivoting forceps leg, which can pivot relative to the fixed forceps leg via a pivot element and which is electrically insulated from the fixed forceps leg is provided, with the forceps legs essentially being made from biocompatible metal. The pivot element is likewise essentially made from biocompatible metal and attaches directly to the moving forceps leg. An insulating body electrically insulating the pivot element and the moving forceps leg from the fixed forceps leg is arranged on or fixed to the fixed forceps leg as a pivot support, on which the moving forceps leg is supported by the pivot element.

Abstract: Tissue clamp systems and methods assess the transmurality of a lesion created by ablation. Exemplary clamp systems for ablating tissue include a first jaw, an ablation element mounted on the first jaw, a second jaw, and a sensing element mounted on the second jaw. The sensing element can be configured to assess transmurality of a lesion created by the ablation element. Systems may also include a connection mechanism that connects the ablation element and the sensing element to a connector for connecting the ablation element and the sensing element to an ablation system.

Abstract: The present disclosure relates to electrosurgical instruments for use in sealing various tissues. The instrument includes a housing having a shaft attached thereto and an end effector assembly attached to a distal end of the shaft, wherein the end effector assembly includes first and second jaw members attached thereto. The jaw members are movable relative to one another from a first position for approximating tissue to at least one additional position for grasping tissue therebetween. The jaw members have an elastomeric material disposed on an inner facing tissue contacting surface thereof with the elastomeric materials including an electrode disposed therein. The electrodes are offset a distance X relative to one another such that when the jaw members are closed about the tissue and when the electrodes are activated, electrosurgical energy flows through the tissue in a generally coplanar manner relative to the tissue contacting surfaces.

Abstract: The present disclosure provides various embodiments of an external fixation connection rod having articulatable joints that can be attached to external supports, such as rings. In some embodiments, the fixation connection rod includes a telescopic rod and connecting mechanisms for coupling the joints of the connection rod to the external supports, and the connecting mechanisms are operable to substantially lock the orientation of the joints. In some other embodiments, the connection rod includes a housing having parallel axial bores defined therethrough and sleeves slidably disposed in the axial bores. Also included in the present disclosure are methods of maintaining the orientation of first and second fixator rings for immobilizing bone segments.

Abstract: A bone treatment device comprises a shaft having a tubular wall, a lumen extending within the tubular wall, openings through the tubular wall, and anchoring elements adjacent the openings that can be deployed out of the openings in the presence of an actuating force within the shaft lumen. The bone treatment device may further comprise an actuator configured to be received within the shaft lumen to deploy the anchoring elements out of the openings.

Abstract: A multi-articular fracture fixation device having a adjustable modulus of rigidity. The implant apparatus includes modular tensioning elements that can be disposed in a ball-and-socket linear array along a length of connecting wire within a medullary canal or percutaneously. The connecting wire includes a threaded end and a stop member at the opposite end, and when a lock nut is threadably disposed on the threaded end and tightened, at least two of the tensioning elements in the array may be swiveled relative to one another and arranged to introduce curvature as desired along the length of the array. Tightening the lock nut is also employed to adjust the modulus of rigidity to be retained during healing.

Abstract: Treating fractures using one or both of an implant, such as an intramedullary nail, and a fastening assembly, such as a lag screw and compression screw assembly. The implant in some embodiments has a proximal section with a transverse aperture having a non-circular cross-section that may be shaped to selectively constrain the fastening assembly within the transverse aperture. Two or more components of the fastening assembly may be received to slide, in a controlled way, in the transverse aperture of the implant, and to cooperate to resist a force moment applied thereto. Without the presence of one of the components, such as the lag screw, another component, such as the compression screw may not resist a force moment applied thereto.

Abstract: Systems, including methods, apparatus, and kits, for fixing bones, such as rib bones, with bone plates.

Abstract: This invention relates to methods and instruments for performing a surgical procedure in a disc space between adjacent vertebrae. The instruments include a distractor and a cutting instrument. In one embodiment the distractor includes a body portion and a pair of flanges extending along opposite sides of the body portion such that a slot is formed between the flanges and the body portion. The cutting instrument is positionable over the body portion and into the slots of the distractor so that the flanges are positioned between the cutting instrument and the adjacent tissue.

Abstract: A bone rifling system for use in prosthesis, which allows improved prosthetic bone fixation. The system comprises orthopedic undercut reamer, which can cut controlled internal groove circles or spiral grooves on the internal surface of host bone. The system converts the commonly reamed smooth bone to grooved or rifled bony tube. Used together with bone cements, the bone rifling system ensures prosthetic bone fixation by significantly increasing the pull out strength, and decreasing the rate of clinical loosening and failure of replacement joints. Also disclosed is a method for preparing a bone for a prosthesis using such a bone rifling system to cut grooves in a host bone for increased prosthetic bone fixation.

Abstract: Methods and apparatus for performing knee arthroplasty, including, but not limited to, bicruciate retaining knee arthroplasty, are described herein. Methods and apparatus for preparing a distal femur for a femoral implant as well as methods and apparatus for preparing a proximal tibia for a tibial implant are described. These methods and apparatus, in at least some embodiments and uses, facilitate decreasing the complexity of knee arthroplasty procedures such as bicruciate retaining procedures, while maintaining, if not improving on, the safety, accuracy and/or effectiveness of such procedures.

Abstract: Methods and apparatus for performing knee arthroplasty, including, but not limited to, bicruciate retaining knee arthroplasty, are described herein. Methods and apparatus for preparing a distal femur for a femoral implant as well as methods and apparatus for preparing a proximal tibia for a tibial implant are described. These methods and apparatus, in at least some embodiments and uses, facilitate decreasing the complexity of knee arthroplasty procedures such as bicruciate retaining procedures, while maintaining, if not improving on, the safety, accuracy and/or effectiveness of such procedures.

Abstract: A surgical instrument for moving tissue, such as bone segments, and more specifically vertebrae of a spinal column, is provided. In particular, a spine compression and/or distraction instrument that can be used to reposition vertebrae is provided. Further, methods for using the surgical instrument to compress and/or distract vertebrae of a spinal column are also provided.

Abstract: An apparatus and methods for delivery of reinforcing materials to a weakened or fractured bone is disclosed. An apparatus for delivering a reinforcing mixture to a bone including a tube having a proximal end, a distal end, and a longitudinal axis therebetween, wherein the tube has at least one inner lumen capable of allowing a bone reinforcing mixture to pass therethrough; a balloon engaging the tube wherein the balloon expands from a substantially deflated state to a substantially inflated state upon the bone reinforcing mixture entering the balloon; and at least one light guide extending through the tube into the balloon to guide a light into the balloon.

Abstract: A slap hammer including an adjustable striking member and a releasable retaining mechanism for releasably retaining a sliding weight is disclosed. One described slap hammer comprises a guide rod having a first end and a second end; a striking member coupled to the second end of the guide rod and movable relative to the first end of the guide rod; a sliding weight slidable along the guide rod between the first end of the guide rod and the striking member; a biasing element positioned between the sliding weight and the first end of the guide rod, the biasing element biasing the sliding weight towards the second end of the guide rod; and a releasable retaining mechanism for releasably retaining the sliding weight against the action of the biasing element.

Abstract: A tool device includes a frame, a barrel extending from the frame, a first magazine having first passages for containing work or drive bits, and a second magazine having second passages for containing fasteners. A shaft is movable over a path that extends through the barrel. When a second passage is vacant and aligned with a selected first passage, a work bit in the first passage is urged by the shaft through the vacant second passage and through the barrel, to be set at a distal end of the barrel for use on a work object. When a second passage containing a fastener is aligned with a selected first passage, a drive bit in the first passage is urged by the shaft to engage the fastener and advance the fastener to the distal end of the barrel, to enable the bit to drive the fastener into the work object.

Abstract: An intracorporeal grasping device includes a tubular member for entering a lumen of a human body and the tubular member having a distal end portion. An elongated core member is disposed within the interior cavity of the tubular member for rotational or slidable movement within the tubular member and the elongated core member having a proximal end portion and a distal end portion. The elongated core member includes a grasping configuration for capturing an object (e.g., clot or debris) therein.

Abstract: An apparatus, device and method are provided to enable performing a treatment in a minimally invasive fashion in a pericardial space. The device includes a needle having a sensing means to detect substantially different bodily tissues to enable a practitioner to determine when the distal end of the needle is in the pericardial space; an anchoring means to secure the distal end of the needle inside or in proximity to the pericardial space; and a delivery means for delivering a guidewire to the pericardial space to perform the treatment.

Abstract: Robotic devices, systems, and methods for use in telesurgical therapies through minimally invasive apertures make use of joint-based data throughout much of the robotic kinematic chain, but selectively rely on information from an image capture device to determine location and orientation along the linkage adjacent a pivotal center at which a shaft of the robotic surgical tool enters the patient. A bias offset may be applied to a pose (including both an orientation and a location) at the pivotal center to enhance accuracy. The bias offset may be applied as a simple rigid transformation from the image-based pivotal center pose to a joint-based pivotal center pose.

Abstract: Configurations are described for conducting minimally invasive medical interventions utilizing elongate robotically controlled instruments and assemblies thereof. In one embodiment, a junction sheath may be utilized to facilitate surgical triangulation of two interventional instrument assemblies, while also directing them to the surgical theater through a minimal single wound or surgical port. One or more instrument drivers, and one or more master input devices comprising an operator workstation, may be utilized to independently and simultaneously control multiple degrees of freedom pertinent to each instrument comprising one or more instrument assembly.

Abstract: A flexible wrist-type element and methods of operation thereof, including variations having an angularly moveable hub housing a rotatable and operable end effector driven via a drive train having one or more universal-type joints and/or other flexible couplings moveable via an input mechanism within a housing.

Abstract: Systems, devices, and methods for robot-assisted microsurgical stenting are described herein. In some embodiments a tele-robotic microsurgical system for eye surgery include: a tele-robotic master and a slave hybrid-robot; wherein the tele-robotic master has at least one master slave interface controlled by a medical professional; wherein the slave hybrid-robot has at least one robotic arm attached to a frame releasably attached to a patient's head; wherein the at least one robotic arm has a parallel robot and a serial robot; and wherein the serial robot includes a stenting unit which includes a support tube, a pre-bent tube mounted within the support tube and a guide wire extending from the support tube for carrying a stent and for piercing a blood vessel.

Abstract: Provided is a medical robot system which includes a medical manipulator capable of handling organs such as a uterine of different shapes and sizes. The medical robot system includes a robot arm, a medical manipulator which is detachably provided in the robot arm and supports an organ to a predetermined position, and a controller unit operable by an operator to control the robot arm and the medical manipulator. The medical manipulator also includes a first arm portion in a base side thereof, a second arm portion in a front side thereof for supporting the organ, and a connection portion connecting the first arm portion with the second arm portion. The control unit adjusts a relative direction of the second arm portion and the first arm portion and a length of the second arm portion in a telescopic manner thereby being suitable for organs of various shapes and sizes.

Abstract: A manipulator includes a main arm, of which the proximal end bears a drive, and a proximal manipulation structure, and of which the distal end bears a controlled distal structure that may itself bear a surgical tool. The main arm passes through a surgical trocar. The proximal manipulation structure includes two opposed contact zones and stress sensors positioned in a central zone between the two opposed contact zones. The stress sensors operate the drive as a function of the stresses applied to the contact zones in order to produce the pivoting and rotating movements of the surgical tool with respect to the main arm. This ensures that there is optimal decoupling of the movements in the various degrees of freedom, thus making it easier to obtain movements through stressing operations that are natural to the operating surgeon.

Abstract: A cosmetic device includes a grip, a keratin removal head detachably attached to the grip, and an epilator head detachably attached to the grip. Either one of the keratin removal head and epilator head is attached to the grip.

Abstract: A compression clip system where compression is used to close a tissue opening, reduce the volume of an organ, ligate dilated blood vessels or compress tissue adjacent to various other types of lesions to induce healing. Compression prevents bleeding and the leakage of body fluids into a body cavity. The opening may be surgery induced as in gastrectomies or formed naturally such as peptic ulcers and hemorrhoids. The system may include a compression clip, a suitable clip applier, a grasper assembly and an endoscope all brought to the compression site via a multi-lumen sleeve.

Abstract: In one embodiment, a continuous suture passer device may include a first jaw, a second jaw, a tissue penetrator which may penetrate through tissue positioned between the first and second jaws, and a suture shuttle which may be releasably secured to the tissue penetrator and adapted to carry a suture. Further, the device may include an actuator which may manipulate at least one of the first or second jaws and the tissue penetrator, and the second jaw may have a suture shuttle retainer seat on which the suture shuttle may be releasably secured. The tissue penetrator may be movable towards the second jaw such that the suture shuttle carried by the tissue penetrator may be transferred to the shuttle retainer seat on the second jaw. Additionally, the first and second jaws may be substantially parallel to one another at any position to which the at least one jaw is manipulated.

Abstract: A tissue engineering construct made from a nonwoven fabric. The fabric is made from first and second staple fibers. The first staple fibers are made from a first biocompatible, bioabsorbable material, and the second staple fibers are made from a second biocompatible, bioabsorbable material. The first material has a melting temperature lower than the second material. The fabric is formed into a three-dimensional construct suitable for the repair of urinary tract structures.

Abstract: Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.