Abstract: An applicator insertable into a living body includes a nozzle having an elongated nozzle main body and a nozzle head on a front end side of the nozzle main body and through which liquid together with gas is expelled, with the nozzle main body including a flexible curved section. The applicator also includes an outer tube in which is positioned a portion of the nozzle main body so as to be movable along a longitudinal direction. The angle or degree of curvature of the curved section is changed by inserting the curved section into the outer tube to thereby adjust the direction of the nozzle head relative to the axis of the nozzle main body. In addition, a longitudinally extending gap exists between the outer tube and the nozzle. The gap functions as a discharge path for discharging the gas within the body cavity.

Abstract: A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood contacting medical system includes at least one seal, and a purge system via which a flushing fluid is introduced under pressure over a blood-side face of the seal and caused to flow through a space on the blood side of the seal. The system can further include a rotatable member. The space on the blood side of the seal can be in fluid connection with an annular space adjacent to a rotating element operatively connected to the rotatable member.

Abstract: The present invention relates to a method for checking and/or monitoring the leak tightness of a plurality of pneumatically or hydraulically actuated actuators of a machine, in particular a plurality of valve actuators of a medical treatment machine, wherein pressure is exerted on the actuators in different combinations during the operation of the machine, wherein the common pressure drop occurring during a stationary operating phase at the actuators on which pressure is exerted in the respective combination is measured for a plurality of different combinations of actuators on which pressure is exerted, and wherein a respective leak tightness value is determined for individual actuators and/or groups of actuators with the pressure drop which is measured for those combinations and in which the respective actuator and/or the respective group of actuators on which pressure is exerted being taken into said leak tightness value.

Abstract: A nozzle for jetting devices is described comprising e.g. one patterned silicon substrate enabling semiconductor mass production. The method of manufacturing the nozzle is characterized by using one mask layer deposited on the silicon substrate. The etching of the silicon substrate is done by means of a first isotropic etching step and a second anisotropic etching step through the mask layer, resulting in a perfectly aligned nozzle.

Abstract: A drug delivery device is provided that includes a device body, a number of solid, compressed drug tablets, and a retention frame. The device body includes a drug reservoir lumen and a retention frame lumen. The number of solid, compressed drug tablets are positioned in the drug reservoir lumen, and the retention frame is positioned in the retention frame lumen. The drug tablets may be mini-tablets aligned in the drug reservoir lumen, with an interstice formed between any two adjacent drug tablets facilitating deformation of the device body. Systems and method are also provided for loading a drug delivery device. In one embodiment, the method includes positioning one or more solid drug units upstream of the drug delivery device; and driving the drug units into the drug delivery device with a flow of pressurized gas.

Abstract: The present disclosure provides electrode structures and integrated electrode structures having one or more conductive materials coextruded with one or more dielectric materials. The disclosed electrode structures can be configured for use as analyte sensors. Also provided, are methods of making and using the electrode structures and integrated electrode structures described herein.

Abstract: Devices capable of deterring or preventing bulk extraction of drugs from, for example, drug-delivery systems are exemplarily disclosed. In one embodiment, such a device may include a package releasably retaining a drug and an agent. The agent is configured to suppress a physiological effect of the drug when the agent contacts the drug or is coadministered with the drug. The cell package is configured such that an amount of the drug is selectively releasable with respect to the agent when the package is operably proximate to an encoded key. The package, however, may be configured to impose a relatively high likelihood that either the drug will not be accessed or the drug will be contaminated by the agent if access to the contents of the package is sought without the use of an encoded key.

Abstract: A drug storage and delivery device (1) comprising a reservoir (102) containing a liquid, a vial (101) containing a dry drug, such as a lyophilized drug, means (110) for forcing the liquid from the reservoir to the vial, via an established fluid connection, and valve means (106-108) to ensure a tight fluid connection between reservoir and vial can be established before the fluid paths are opened.

Abstract: A surgical device comprising a container and a tether used for delivering a sterile appliance into a body cavity during endoscopic procedures. Once positioned in the body cavity, a force is applied to the container through the tether. The force opens the container and releases the sterile appliance into the body cavity. In various embodiments, gas or liquid may be used to open the container.

Abstract: In one embodiment, the present disclosure provides a biodegradable, self-powered medical device for preventing or reducing reperfusion injury, comprising a galvanic cell, the galvanic cell comprising: a first biodegradable electrode member; and a second biodegradable electrode member comprising a biodegradable conductive polymer and an electrode-releasable therapeutic agent, wherein the galvanic cell generates an electric force sufficient to cause the electrode-releasable therapeutic agent to be released from the biodegradable conductive polymer and elute to a target location. The device may further include a reservoir material containing a burst-release therapeutic agent.

Abstract: Steerable medical delivery devices and their methods of use.

Abstract: The nose device has a conical portion with a distal end intended to be arranged adjacent a nose bone and a proximal end intended to be arranged adjacent a nostril. A screw winding is arranged centrally at the outer surface of the conical portion. A tab portion is arranged at the proximal end of the conical device. The nose device is inserted in the nose of the person until the distal end is positioned adjacent the nose bone of the person. Then, the nose device is rotated so that the distal end is positioned adjacent the nose bone of the person. When the nose device is rotated, the screw windings cooperate with the walls of the nose channel in order to pull them slightly outwards and stretch them, in order to thereby keep the nose channels open. A filter may be arranged for filtering the inhaled air.

Abstract: A syringe assembly includes a syringe barrel having an inside surface defining a chamber, an open proximal end, a distal end, and an outlet; a plunger assembly disposed at least partially within the syringe barrel, including an elongate plunger rod having a locking flange formed thereon; and a plunger head having a distal sealing surface, the plunger rod being engageable with the plunger head such that the plunger rod is adapted to move the plunger head within the chamber of the syringe barrel through an injection cycle; and a flange lock disposed at the open proximal end of the barrel. The flange lock is integral with the open proximal end of the syringe barrel. During the injection cycle, the flange lock engages the locking flange of the plunger rod so as to prevent removal of the plunger rod from the syringe barrel.

Abstract: A method of removing air from a flow path of a medical fluid injection system is described. An exemplary method performed by the medical fluid injection device includes delivering a first amount of fluid to a fluid flow path, isolating fluid flow along the flow path, forming a vacuum condition upstream of the fluid isolation, re-establishing fluid communications along the flow path, and delivering a second amount of fluid to the flow path.

Abstract: The present disclosure relates to catheterization systems and components thereof. In one embodiment of the present disclosure, a catheterization system is disclosed that includes a catheter including a body with proximal and distal ends and defining first and second lumens extending therethrough, and a stylet. The stylet includes first and second stylet portions each having proximal and distal end regions, wherein the distal end regions of the first and second stylet portions together define a tapered penetrating portion. The first and second stylet portions are configured and dimensioned to be slidably positioned within the first and second lumens of the catheter, respectively. The first and second stylet portions extend from the proximal end of the catheter and beyond the distal end of the catheter, and are independently movable in relation to each other to facilitate selective removal of the first stylet portion and/or the second stylet portion from the catheter.

Abstract: A device and method for positioning a catheter to establish a fluid access site into the vasculature of a patient includes a luer assembly that incorporates the catheter. Also included is a shuttle assembly that has a stylet for stiffening the catheter. In combination, the stiffened catheter and the shuttle assembly are held on a handle by the interaction of the luer assembly with the handle. Once the stiffened catheter is inserted into the vasculature, the luer assembly is separated from the handle and from the stylet, and is left in place. With this separation, the shuttle assembly is also released to be repositioned and concealed within the handle.

Abstract: A system for providing integrated guidance for positioning a needle in a body has two levels of guidance: a coarse guidance and a fine guidance. The system comprises a non-invasive imaging system for obtaining an image of the biopsy device in the body, for providing the coarse guidance. Furthermore, the system comprises an optical element mounted on the needle for obtaining optical information discriminating tissue in the body, for providing the fine guidance.

Abstract: A surgical seal assembly includes a sleeve housing adapted to be operatively connected to a surgical sleeve, a seal housing adapted for releasable mounting to the sleeve housing and having a seal member with inner portions adapted to permit passage of a surgical object in substantial sealed relation therewith, and a manual lock member associated with the sleeve housing. The manual lock member is adapted for movement relative to the seal housing between a first position corresponding to a release position of the seal housing to permit removal of the seal housing from mounting to the sleeve housing and a second position corresponding to a lock position of the seal housing to secure the seal housing to the sleeve housing. The manual lock member is preferably adapted for rotational movement relative to a longitudinal axis of the seal housing to move between the first and second positions thereof.

Abstract: A tearaway introducer sheath assembly (100,200) having an integrated valve (300). The valve is seated within a valve housing (222) defined by the hub portion (200) of the sheath (200). The valve (300) includes a pair of distally extending opposed side walls or flaps (324) extending to converge at a distal tip (328) having a virtual opening (334) therethrough. The valve further includes a pair of tensioners (340) along outer surfaces of the opposed side walls (324) that extend radially outwardly to engage and bear against the interior valve housing surface (230) to press the opposed side walls (324) together at the distal tip (328) for sealing, both when a dilator extends through the valve and sheath and afterward upon removal of the dilator.

Abstract: The present invention relates to a dressing (1) for protecting the skin around objects projecting out from the skin, the dressing including a first liquid impermeable film layer (2) coated with a skin friendly adhesive (3) on the lower side thereof, i.e. the side intended to adhere to the skin when the dressing is used. According to the invention a body (4) of absorbent material is enclosed between the first film layer (2) and a second liquid impermeable film layer (5), the second film layer being affixed to the first film layer in parts extending beyond the periphery of the body of absorbent material, and the dressing includes an element (8) for facilitating passing of an object projecting out from the skin through the dressing.

Abstract: An improved spindle and bearing combination for a drug delivery device is provided that has a first connection between the spindle and bearing comprising a web and a second connection that replaces the first connection when the web is severed that allows the spindle to rotate relative to the bearing.

Abstract: An adaptor for discriminating connection of an oral tip having a length greater than 0.50 (12.70 mm) to a feeding line and for preventing sealed connection with a standard semi-rigid luer tip having a length less than or equal to 0.50 in (12.70 mm) is disclosed. The adaptor includes a duckbill valve spaced at least 0.50 in (12.70 mm) downstream from a first open end of the body such that when an oral tip is fully inserted into a connection port, the oral tip engages valve flaps of the duckbill valve and opens the valve, and when a standard semi-rigid luer tip is fully inserted into the connection port, the standard semi-rigid luer tip does not contact the valve flaps and the valve flaps remain in a closed position.

Abstract: A resetting mechanism for a reusable drug delivery device. The device comprises a spindle and a spindle guide engaging the spindle. During a resetting step of the resetting mechanism, the spindle rotates while the spindle guide does not rotate.

Abstract: A method and system for priming a drug delivery device. The drug delivery device includes a forced priming feature that requires the user to move the dose dial sleeve axially to cause the spindle to pre-load a cartridge bung before a first dose can be dialed.

Abstract: A spindle for driving a bung of a cartridge. The spindle includes a generally circular shaft having an outer surface. The generally circular shaft extends from a distal end to a proximal end of said circular shaft. A first helical groove is provided along a first portion of the outer surface. The first helical groove having a first pitch. A second helical groove provided along a second portion of the outer surface of the generally circular shaft. The second helical groove overlapping the first helical groove. The second helical groove having a second pitch.

Abstract: A method and system for a dose setting mechanism of a drug delivery device. The dose setting mechanism includes an inner housing having a helical groove along an external surface of the housing. The inner housing includes a rotational stop feature near one end of the helical groove. The dose setting mechanism also includes a dial sleeve rotatably engaged with the helical groove of the inner housing. When a user rotates the dial sleeve to select a dose, the rotational stop member prevents the user from selecting a dose greater than a pre-defined maximum selectable dose.

Abstract: A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.

Abstract: The invention is directed to a laser catheter (1) for bypass surgery, wherein the distal part (2) of the catheter (1) is provided with: a tubular arrangement (3) of optical fibres (4) having distal ends (5) defining a ring-shaped light emergence surface (6) for emitting a tubular bundle of light beams in the distal direction (D) of the catheter (1); and a stop surface (7) extending around the tubular arrangement (3) of optical fibres (4) and facing in the distal direction (D), the stop surface (7) being arranged at a distance (A) proximally from the light emergence surface (6). The light emergence surface (6) slants at a slanting angle (?) in the range of [20°, 60°] with respect to the longitudinal axis (8) of the catheter (1). The invention further relates to an assembly comprising such a catheter.

Abstract: A flow element (50) for use with flexible needles and flexible needle assemblies (10) to minimize flow occlusion within a flexible needle (15) is provided. The flow element (50) is particularly suited for uses with a flexible needle (15) for minimizing incidence of post-dural puncture headache. The flow element (50) includes a body having an internal flow path for conducting a fluid through a flexible needle, and an anti-restriction member (56). The anti-restriction member (56) includes an elongated body (58), a proximal end (70) coupled to the body within the internal flow path, and a distal end (60) for positioning at least a portion of the elongated body within a flexible needle.

Abstract: The invention relates to a hair removal device (1) having a hair removal unit (30) and a skin cooling unit (10), wherein the skin cooling unit (10) has a skin contact surface (11), and the skin cooling unit (10) is equipped to apply an application substance (80) onto the skin by way of the skin contact surface (11) during use of the hair removal device. In addition to the cooling of the skin by means of contact cooling, a further cooling effect may also be achieved in such a hair removal device in that an application substance is applied, which contributes to the cooling of the skin, for example, by means of evaporation. The hair removal device may comprise a removable attachment, which also comprises at least the skin.

Abstract: An ocular device for insertion into an eye is provided and includes a body having an anterior surface and a posterior surface for placement on one of superior sclera and inferior sclera of the eye. The posterior surface is defined by a base curve that is substantially identical to a radius of curvature of the one of the superior sclera and inferior sclera of the eye. In one embodiment, the ocular device serves as an ocular drug delivery device and contains an active pharmaceutical agent, a lubricant, etc.

Abstract: The composite wound dressing apparatus promotes healing of a wound via the use of a vacuum pump. The vacuum pump applies a vacuum pressure to the wound to effectively draw wound fluid or exudate away from the wound bed. The vacuum pump is tethered to the wound dressing and is portable, preferably, carried by the patient in a support bag, which permits patient mobility. Moreover, the patient does not need to be constrained for any period of time while exudate is being removed from the wound.

Abstract: Packaging for an extra-labial fluid voiding apparatus includes a tube having a cylindrical wall, a closed end, and an open end. The cylindrical wall and closed end define a cavity that can contain the voiding apparatus. The cylindrical wall is pliable and has an inner diameter. A cap is adapted to respectively close and open the tube at the open end. The cap has an end plate with an annular flange extending therefrom. The annular flange is rigid and has an outer diameter. The annular flange is insertable into the cavity at the open end of the tube and within the inner diameter of the cylindrical wall. The outer diameter of the flange is larger than the inner diameter of the cylindrical wall to a degree such that the outer diameter and the inner diameter are engageable in a press-fit arrangement, when the cap is connected to the tube.

Abstract: Apparatuses and methods for producing an absorbent article are provided. Graphics are printed on a substrate, where consecutive graphics are separated in the machine direction by a first repeat pitch length. The substrate is activated, or incrementally stretched, in a first direction to define a second repeat pitch distance. The second repeat pitch distance is substantially equal to the pitch length of the absorbent article pitch length. The substrate is activated, or incrementally stretched, in the machine direction subsequent to printing to increase the repeat pitch distance. The substrate may be activated in the cross direction to increase the width of the substrate. Only portions of the substrate may undergo activation. The activation may be performed with rollers and/or stamping.

Abstract: Provided herein are composition comprising a farnesene interpolymer. The farnesene interpolymer can be derived from a farnesene and at least one vinyl monomer. In some embodiments, the mole percent ratio of the farnesene to the at least one vinyl monomer is from about 1:4 to about 100:1. In certain embodiments, the farnesene is ?-farnesene, ?-farnesene or a combination thereof. In some embodiments, the at least one vinyl monomer is ethylene, an ?-olefin such as styrene, or a substituted or unsubstituted vinyl halide, vinyl ether, acrylonitrile, acrylic ester, methacrylic ester, acrylamide or methacrylamide, or a combination thereof.

Abstract: According to an absorptive article (disposable diaper) 10 of the present invention, an absorber (absorptive structure) 12 is provided with a first region 55 disposed on an internal surface sheet 41 side and having a higher content ratio of the superabsorptive polymer than a content ratio of the hydrophilic fiber, a second region 56 disposed on an external surface sheet 42 side and having a lower content ratio of the superabsorptive polymer than the content ratio of the superabsorptive polymer in the first region and a higher content ratio of the hydrophilic fiber than the content ratio of the hydrophilic fiber in the first region, and a space that penetrates from the external surface sheet 42 side of the second region 56 to the first region 55, and that can be entered by the superabsorptive polymer that is swollen by absorbing a body fluid in the first region 55.

Abstract: The present invention provides a water-absorbent resin produced by a reversed-phase suspension polymerization method, which contains a small amount of a petroleum hydrocarbon dispersion medium remaining therein used in reversed-phase suspension polymerization, and thus reducing an odor originating from the petroleum hydrocarbon dispersion medium, when the water-absorbent resin absorbs water, and also which is suitable for use in hygienic materials; an absorbent material and an absorbent article. More particularly, the present invention provides a water-absorbent resin obtained by subjecting an aqueous solution of a water-soluble ethylenically unsaturated monomer to reversed-phase suspension polymerization in a petroleum hydrocarbon dispersion medium in the presence of a surfactant, wherein the amount of the petroleum hydrocarbon dispersion medium remaining in the water-absorbent resin is 2,000 ppm or less; and an absorbent material and an absorbent article using the same.

Abstract: [Problem] To provide an absorbent pad that can be easily unstuck from a diaper or lower-body underwear [Means for Solving Problem] An absorbent pad 200 where a hook tape 32 is exposed on an outer surface of the absorbent pad 200 configured by forming an attachment panel 31, that can be divided, via a folding portion 31c, into an extended portion 31a provided with the hook tape 32 formed on the top surface side thereof and a base portion 31b fixed to an outer sheet 25; and by folding back the attachment panel 31 via the folding portion 31c such that the extended portion 31a is layered on the base portion 31b side

Abstract: An absorbent article (1), such as an incontinence protector, sanitary napkin or the like, includes a liquid permeable top sheet (3), a backing sheet (4) and an absorbent core (5,6,7) enclosed therebetween. The absorbent core includes an upper absorbent layer (5) proximal to the top sheet and a lower absorbent layer (6) distal to the top sheet. An elongated hole (8) extending in the longitudinal direction of the article is made in the absorbent core. First and second elastic elements (9,10) attached to opposite lateral edges of the absorbent core (5,6,7) extend along the hole in a longitudinal direction and the top sheet (3) is affixed to the elastic elements and to the bottom of the hole (8).

Abstract: It is intended to provide an absorbent article which has a barrier sheet for insulating the wearer's skin from excretory substances and in which the opening area in the connecting section formed in the barrier sheet is prevented from narrowing. An absorbent article which comprises a barrier sheet (3) which is located in the body side of a chassis and formed in a separable manner from the chassis in the crotch area, and a pair of leakage-blocking cuffs (4) which are located in the body side of the barrier sheet (3) and extend along the front-back direction (Z). The barrier sheet (3) is bonded to the leakage-blocking cuffs (4) via a bonding site (48). The bonding site (48) is located at a free marginal section of the leakage-blocking cuffs (4) separable from the chassis and overlaps an elastic member of the barrier sheet (39).

Abstract: A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove. The inner housing guides a driver having either a blocking or locking member disposed inside the driver that can lock a flexible tab to an internal groove during dose delivery in the inner housing such that the driver follows the path of the groove and to advance a spindle to move a cartridge bung. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing.

Abstract: Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.

Abstract: A dispenser is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials that may react upon exposure to air, such as glue. Means are provided in the dispenser to effect controlled delivery of a pre-determined amount of the substance contained in the dispenser. A one-way valve is provided to hermetically seal the portion of the dispenser containing the substance to be dispensed.

Abstract: Materials and methods for making conformable stents. The stents can be generated by, for example, injecting a fluid into a scaffold on the outer surface of an angioplasty balloon inflated at the site of a stenosis, and allowing the fluid to harden or set, thus generating a stent that can remain in the vessel at the site of stenosis.

Abstract: Embodiments of the invention provide a device, system and method for the transdermal iontophoretic delivery of therapeutic agents. One embodiment provides a method comprising applying first and second patches to the skin. The first patch comprises a delivery electrode, a therapeutic agent and two lateral electrodes. The second patch comprises at least a delivery electrode. A first current is delivered to the skin and create a first driving force to transport the agent into the skin. A second current is delivered to the skin and creates a second driving force to oscillate the agent in a direction substantially parallel to the skin. The agent is transported across the skin using the first driving force to propel the agent into the skin, and the second driving force to oscillate the agent substantially parallel to the skin surface so that it is sieved through pathways of least diffusional resistance in the skin.

Abstract: Embodiments of the invention provide electrode assemblies and associated methods for the iontophoretic transdermal delivery of therapeutic agents. Many embodiments provide a corrosion resistant electrode for the iontophoretic transdermal delivery of various therapeutic agents. Such embodiments allow for the iontophoretic transdermal delivery of therapeutic agents such as iron compounds for prolonged periods without any substantial corrosion of the electrode, impedance increases or discoloration or irritation of the skin. Embodiments of the invention are particularly useful for the long term treatment of various chronic medical conditions such as iron deficient anemia.

Abstract: The present invention describes pharmaceutical formulations and methods suitable for iontophoretic delivery of the formulations to a subject. The formulations comprise an immunomodulator, such as imiquimod, and optionally include various agents and excipients. The formulations can be used as a treatment for skin diseases and conditions such as actinic keratosis, basal cell carcinoma and genital warts. The short term iontophoretic delivery of the formulations results in the creation of a depot effect in the skin of the subject, allowing for a sustained delivery. The shortened delivery time minimizes local side effects at the application site.

Abstract: Cerebral Catheter devices and methods for use are provided. The catheter devices provided may include an anti-thrombotic agent coating on the exterior surface. The catheter devices may include unique tip configurations to allow improved fluid delivery capabilities. Further, the catheter devices may also or alternatively include one or more sensor devices in communication with a controller that allow automatically adjusting the delivery of a therapeutic fluid, for example a vasodilator, in response to the condition sensed by the catheter device, such as increased pressure. Moreover, the catheter devices may also be used in conjunction with blood flow transducers to detect and timely prevent and treatment vasospasms or other conditions. Methods for preventing and treatment vasospasm, neoplasm, or other pathological conditions while prolonged using the catheter device are also provided.

Abstract: Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter and a needle disposed within the catheter and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle may be configured to create a tissue space surrounding a distal or lateral surface of the needle, into which the bioactive agent to be infused.

Abstract: Methods, apparatus and compositions are provided for treatment of cancer of a selected organ by intraluminal delivery of oncolytic agents through a blood vessel or duct leading to the cancer tissue. During the time the oncolytic agents are being applied to the targeted tissue downstream, the designated vessel or duct can be selectively occluded to increase concentration and pressure of the applied agents at the target site. Oncolytic compositions including oncolytic viruses formulated with delivery visualization markers are provided.