Abstract: A safety needle device for a medical injector supporting a needle projecting forwardly from the front of the injector body has a tubular sleeve for a supported needle, the sleeve being slidable rearwardly with respect to the needle to expose at least the tip thereof. The sleeve has a forward end for contacting an injection site and a removable cover is engaged in sealing contact with the forward end of the sleeve. The sleeve may have an in-turned flange at its forward end defining an orifice through which the needle projects when the sleeve slides rearwardly. The removable cover may effect a seal to that flange.

Abstract: The present invention discloses multiple approaches to preventing the capsule walls and other material from interfering with the performance of an electronic device once the device is activated by surrounding fluid. In accordance with the teachings of the present invention, a miniature ingestible device (MID) may be created using excipients and films. The MID, in accordance with various aspects of the present invention, will have a coating or laminating surrounding an electronic device and separating and isolating the device from the pharmaceutical product or drug within the capsule once the capsule is ingested as well as from the capsule itself as the capsule walls begin to collapse during the disintegration process.

Abstract: A hazardous agent injection system including from about 0.02 ml to about 4.0 ml of methotrexate at a concentration of from about 7.5 mg/ml to about 150 mg/ml; a needle-assisted jet injector including a container configured to contain the methotrexate; a injection outlet member associated with the container; an injection-assisting needle coupled to the injection outlet member; a firing mechanism associated with the container; an energy source associated with the firing mechanism; and a trigger mechanism associated with the firing mechanism, wherein the needle-assisted jet injector is configured to eject the methotrexate from the injection outlet member such that the Cmax, Tmax and bioavailability of the needle-assisted jet injected methotrexate falls between about 80% and about 125% of the Cmax, Tmax and bioavailability of methotrexate delivered by a hand-powered syringe.

Abstract: Described herein is an implantable device including: a housing including a connection opening defined therein, wherein the connection opening includes posts and slots and is configured to receive at least one connection associated with a neuromodulation device; a connection holding cap having posts, wherein the posts are configured to oppose the posts of the connection opening and wherein the connection holding cap is configured to receive the at least one connection associated with the neuromodulation device and configured to be operably connected to the connection opening by interconnecting the opposing posts after receiving the at least one connection associated with the neuromodulation device; a neuromodulation device holder operably connected to the device housing and configured to receive the neuromodulation device and secure the neuromodulation device within the device housing; and a cover operably connected to the device housing and configured to seal the device housing.

Abstract: Vascular introducer systems, kits, and methods providing or creating access to vessels, such as radial or femoral arteries, are disclosed. A vascular introducer system includes a removable inner tubular member, a removable outer tubular, tear-away member, and an expandable passage member positioned between the inner and outer tubular members. The removable inner tubular member and the removable outer tubular, tear-away member help protect and maintain a contracted configuration of the expandable passage member when the introducer system is advanced into a vessel. The expandable passage member includes an inner surface configured to receive an elongate treatment device, for example, following removal of the inner and outer tubular members. In some examples, the expandable passage member includes one or more kink-resistant members extending along a portion of the passage member.

Abstract: A plurality of different vascular access assemblies are described which protect a clinician from accidental needle stick injury upon withdrawal of a needle from a catheter assembly. Each of the vascular access assemblies include a safety device for guarding the needle tip of the needle upon withdrawal of a needle from the catheter assembly.

Abstract: The present invention discloses a catheter instrument (1000) comprising a needle tip shielding device (100), a needle (303), a needle carrying unit, and a catheter unit, said catheter unit comprising a catheter hub (200) and a catheter (201), and said needle tip shielding device (100) and said catheter hub (200) being separable from one another, wherein said needle tip shielding device (100) is kept in contact with said catheter unit upon withdrawal of said needle (303) via at least one interface surface between said needle tip shielding device (100) and said catheter unit, and wherein said at least one interface surface of said needle tip shielding device (100) being at least partly of a first polymeric material and said at least one interface surface of said catheter unit being at least partly of a second polymeric material.

Abstract: A trocar comprising an alignment channel and an instrument seal comprising a bending portion and a base portion. The bending and base portions of the instrument seal are spaced relative the alignment channel such that when a surgical instrument is retracted the bending portion inverts and the lip does not enter the alignment channel.

Abstract: Angiocatheter systems with anti-leak features for helping to prevent leaking or blood splashes that could possibly pose a health risk to the patient and/or practitioner. The systems may feature slidable anti-leak components that regulate opening and closing of the hub's hole, wherein the anti-leak components are moveable upon insertion or removal of a secondary device. The systems may feature a moveable inner wall or components on the inner wall that regulate opening of the hub's hole, wherein the wall or components of the wall are movable upon insertion or removal of a secondary device. The systems may feature compressible valves or twistable bases that regulate opening of the hub's hole, wherein the valves or bases are manipulated upon insertion or removable of a secondary device.

Abstract: A method of manufacturing a microneedle including forming a plurality of first linear grooves on a substrate in parallel to one another along a first direction using grinding and forming a plurality of second linear grooves on the substrate in parallel to one another in a second direction intersecting the first direction using grinding. At least one of the forming of a plurality of first linear grooves and the forming of a plurality of second linear grooves includes forming first stage grooves using a first dicing blade; and processing the first stage grooves by tracing the first stage grooves using a second dicing blade having a side surface different from that of the first dicing blade to thereby form second stage grooves.

Abstract: An automatic injection device including a housing element, at least one resilient element arranged to be located within the housing element, a syringe including at least one syringe piston, a needle guard adapted for selectable positioning with respect to the housing element and a selectable driving element adapted, when actuated, to be driven by the at least one resilient element for initially displacing the syringe relative to the housing element from a non-penetration position to a penetration position and thereafter displacing the at least one syringe piston in the syringe to effect drug delivery and displacing the needle guard into a needle guarding position.

Abstract: A folding panel needle guard comprises front and rear panels coupled together at hinges, a collar attached to the front panels at hinges, a guard base element coupled to the rear panels at hinges, a hub and a spring to unfold and lock the front and rear panels in a co-linear needle shielded configuration. The folding panel needle guard is mountable to a needle or syringe assembly.

Abstract: The invention relates to a safe support device for a syringe, said support comprising a support sheath for the body of a syringe, and safety means which comprise an inner sheath suitable for sliding relative to said support sheath between a waiting retracted position, in which said inner sheath is substantially retracted inside said support sheath, and an active protection position, in which said inner sheath projects from said support sheath. The inner sheath has a free end portion formed by a flexible end-piece. The invention also relates to an assembly comprising such a safe support device and a syringe having a body, a piston and a needle disposed at one end of said body.

Abstract: The present invention relates to a cartridge holder assembly for a drug delivery device as well as to such drug delivery device and to a corresponding method of assembly, wherein the cartridge holder assembly comprises: a cartridge holder (14; 40) adapted to receive a cartridge (12) to be filled with a medicinal product to be dispensed by the drug delivery device, wherein the cartridge holder (14; 40) comprises at least one through opening at a distal end section to receive a piercing element (20) being adapted to penetrate a sealing septum (22) of the cartridge (12), a constriction member (26; 42) being adapted to axially abut against the septum (22) and comprising a through opening (34; 52) to receive the piercing element (20), wherein said through opening (34; 52) is adjustable in diameter.

Abstract: A container for collecting, transporting, storing, delivering and dispensing fluid. The container has a hollow tube with an outer circumference diameter and is configured to receive a plunger. The container also has a circumferential seal assembly secured at one end of the hollow tube. The seal assembly outer diameter is substantially similar to the hollow tube outer diameter.

Abstract: A medical appliance having a slidable coating layer that moves in contact with an inner surface of a medical member or that of a lumen and has the slidable coating layer formed at a part thereof which contacts the medical member or the lumen. The slidable coating layer is formed of a composition which does not contain solid fine particles and contains a silicone-based resin which is a product of an addition reaction between silicone having a vinyl group and silicone having a hydrogen group bonded to a silicon atom.

Abstract: The drive assembly comprises a guide nut (4), a locking means (9), and a fastener (14), the fastener being movable with respect to the locking means into and out of a position, in which the fastener engages the locking means with the guide nut.

Abstract: A plunger kit for a medicine syringe provided with a syringe barrel includes a piston having an internal screw and a plunger rod having an external screw. The internal screw and external screw have a mutually non-complementary, basic groove profile and basic thread profile, respectively. A following flank of each thread of the external screw and a groove flank of a corresponding groove of the internal screw are formed such that, when the piston and plunger rod are slidably fit in the syringe barrel and the piston is then slid in a pull direction, the following flank can come into contact with the groove flank more strongly at a first part and more weakly at a second part to increase thread engagement strength between the external screw and the internal screw without any substantial expansion of the piston by the external screw.

Abstract: An injection device has a housing (34), and a carpule container (44) for receiving a carpule (50) having a fluid (52) to be injected and having a piston (48) displaceable in said carpule (50). It further has a piston rod (38) with end plate (46?) which serves, in the context of an injection, to displace the piston (48) of a carpule (50) inserted into the carpule container (44) and thereby to eject fluid (52) from the carpule (50). In order to minimize patient error in adjusting the amount of fluid medication (52) to be injected, the mechanism includes a first component (68) and a second component (92) which link (98) and interact with each other, to control when the carpule container (44) can rotate with respect to the housing (34), and to prevent creation of an axial gap (62) between end plate (46?) and piston (48).

Abstract: An automatic injection syringe assembly having an integrated and tillable medicine container that includes a medicine container within a housing and a conduit assembly. The medicine container includes a piston having an aperture at a distal end thereof for the passage of fluid therethrough. The conduit assembly includes a conduit member that is releasably connected to the housing and has an open proximal end and an open distal end. The open distal end of the conduit member is releasably engaged with the piston and in fluid communication with the piston aperture. The open proximal end and the open distal end of the conduit member are in fluid communication via a conduit within the conduit member.

Abstract: A catheter has at least two irrigated ablation electrodes and a coaxial irrigation tubing to transport fluid to the electrodes by separate and dedicated flow paths. A valve is used to control flow of fluid into the coaxial irrigation tubing by means of a plunger assembly that allows fluid to flow through one lumen of the coaxial irrigation tubing while regulating the flow into the other lumen of the coaxial irrigation tubing in response to the fluid flow rate and pressure applied to the plunger assembly.

Abstract: Positive displacement using a connector with dual diaphragms is provided. For example, the connector includes a single fluid flow path, an air chamber and a valve. The single fluid flow path is configured for delivering fluid to a person and configured for receiving fluid from a person. The air chamber configured for expelling air from the air chamber when an actuator is inserted into the connector and for receiving air into the chamber when the actuator is removed from the connector. The valve plug comprises two diaphragms that separate the air chamber from the single fluid flow path. The valve plug is configured for creating positive displacement by returning the valve plug to its uncompressed state when the actuator is removed from the connector.

Abstract: A coupling apparatus includes a first component having a first non-mechanical valve, a second component having a second non-mechanical valve, and a third component having a first end for coupling with the first valve and a second end for coupling with the second valve. The third component has an elongated bore such that when the first end is coupled to the first valve and the second end is coupled to the second valve, a passageway is defined therethrough. The coupling apparatus includes a breakaway portion disposed between the third component and the second component and the first and second valves automatically close when the second and third components are separated from one another.

Abstract: For the examiner's convenience, a clean text version of the replacement abstract (114 words) is presented below: A blood treatment machine has a housing and a blood treatment module to hold components of an extracorporeal blood circulation. The machine simplifies access to a securing means for securing objects, in particular containers such as bags containing medicinal fluids, that is attached to a rod-shaped means attached to the blood treatment machine. Vertical and horizontal directions are defined by the orientation of the housing during the use of the blood treatment machine. The rod-shaped means has at least one first section and a second section, whereby the axial extent in the second section runs in a different direction than in the first section. In another embodiment, the rod-shaped means has a cropped course.

Abstract: The present invention provides in some embodiments, a method for insert molding a coupling between catheter segments with different diameters and/or a catheter having different diameters. Generally, the method can include the steps of providing first and second tubes having larger and smaller diameters, respectively and positioning the first and second tubes onto a core pin assembly having an outer surface at one section which forms a contoured inner profile for a joint section to join the first and second tubes. Additionally, the method can include injection molding the joint section to join the first and second tubes, to form the catheter tube with the contoured inner profile at the joint section.

Abstract: Needle comprising a polyarylene material comprising a polyarylene. The needle can meet all the advantages of metal, while avoiding its drawbacks. It has a high rigidity and ductility, and is excellent in penetrability and ability to hold a sharp edge. It is easily disposable and recyclable. It is non toxic and non irritant.

Abstract: The invention relates to a catheter apparatus comprising: a catheter; a catheter hub having a distal section and a proximal section, wherein the distal section is joined to the catheter and the proximal section defines a chamber; a needle extending through the catheter hub and the catheter and defining an axial direction, wherein the needle has opposite proximal and distal ends, the distal end forming a needle tip; a needle hub attached to the proximal end of the needle; and a needle guard slidably arranged on the needle, wherein the needle guard is retained in the chamber of the catheter hub when the needle extends through the catheter hub and the catheter, and wherein the needle guard is removable from the catheter hub once the needle tip is received in the needle guard upon withdrawal of the needle from the catheter.

Abstract: A device and a method for manufacturing said device, the device comprising an applicator member and a flexible retention web (1) intended to be introduced into a vaginal cavity (17), said web being equipped with a means (7) for removal and being made from an atraumatic material whereof the dimensions are adapted so as to be able to retain and/or slow down bodily discharges of small quantity, characterized in that: the applicator member comprises a body (8) that is at least partially hollow defining an internal storage volume (9), said body having a proximal end (10) on the one hand, and on the other hand, a distal end (11) intended to be inserted into the vaginal cavity of a user, said distal end having an open section emerging in the internal volume, the web comprises a central zone (13) housed in the internal volume, and at least one peripheral zone (14) protruding from the body so as to cover at least the distal end of the body.

Abstract: An eye treatment apparatus having a guide device structured to guide a nozzle of an applicator to a position in front of an eye is provided. The guide device includes a guide surface and a stop. The guide surface is easily accessible. That is, the nozzle of an applicator may be moved, generally laterally, into contact with the guide surface. The nozzle may then slide over the guide surface to the stop. The stop is positioned so that the nozzle is disposed centrally in front of the eye.

Abstract: Systems and methods for a reduced-pressure interface for providing reduced pressure through a sealing member to a distribution manifold includes a housing having a flange portion and a cavity wall portion such that the cavity wall portion forms a cavity having a tissue-facing cavity opening. A conduit port is coupled to the cavity wall and has a conduit aperture, such that the conduit port is adapted to receive a reduced-pressure delivery conduit. An attachment device is coupled to a tissue-facing side of the flange portion of the housing such that the attachment device couples the housing to the sealing member. Additionally, a cutting element is at least temporarily coupled to the housing proximate to the tissue-facing cavity opening such that the cutting element is adapted to form an aperture in the sealing member when the cutting element is driven into the sealing member with a driving force.

Abstract: A connecting device (2) for use in the treatment of wounds has a conduit (10) which can be evacuated and a flat, extended vacuum-tight carrier (12) on which the conduit (10) is held in a vacuum-tight fashion, wherein the carrier (12) can be disposed onto a vacuum dressing (6) covering the wound. The conduit (10) communicates with the wound space through openings. An adhesion-promoting layer (24) is provided on the side (22) of the carrier (12) facing the wound and has a middle supporting layer (26), a first adhesive layer (28) held on the supporting layer (26) and facing the carrier (12) and a second adhesive layer (30) held on the supporting layer (26) and facing away from the carrier (12). The adhesion-promoting layer does not block an opening (18) in the carrier (12).

Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.

Abstract: An ostomy device (1) has an implant (10) arranged, in use, to be located inside the body of person near the site of a stoma (S). A discharge device (20) is arranged, in use, to provide means for intestinal waste to exit to the exterior of the body of the person. In addition, there is means, in use, to be operatively associated with the implant (10) and removably locate the discharge device (20) at the site of the stoma (S). The discharge device (20) is retained at the site of the stoma (S) by magnetic attraction between the implant (10) and the discharge device (20).

Abstract: A disposable diaper has a central slit formed along the lengthwise direction L so that the absorber can be curved to be convex in the inward direction, and a pair of side slits formed along the lengthwise direction L so that the absorber can be curved to be convex in the outward direction. An average total weight of a water absorbent polymer at the central portion CT and the side edge portion SL, SR is smaller than an average total weight of the water absorbent polymer at the middle portion ML, MR.

Abstract: A method of forming a film resistant to blocking including the steps of providing a polymeric film having a first and second surface; applying the anti-blocking agent in a fluid or molten state to at least the first surface of the polymeric film; and gathering the treated film. The anti-blocking agent may be substantially acrylic free.

Abstract: A packaging medium is provided only on non-skin side surfaces of a third portion and a fourth portion. The length of the packaging medium in a lengthwise direction of a sanitary napkin is shorter than the length of the sanitary napkin. A second portion includes a folded end portion which is formed by a first folded portion provided on a side of a first portion of the sanitary napkin which opposes a first folding portion. The folded end portion is folded over a non-skin side surface of the second portion.

Abstract: A hygienic article for a male is disclosed. The hygienic article includes a tube having a first end adapted to receive a limp penis and a closed second end, the elasticized tube being formed of breathable material, a retaining portion adjacent the first end of the tube adapted to retain the hygienic article on the penis without substantially constricting blood flow, and an absorbent material extending at least within the second end of the tube adapted to absorb fluids.

Abstract: A disposable worn article diaper includes: a central slit formed in an absorber such that the absorber is curved to be convex toward an inward direction toward a wearer in a crotch region; side curved portions formed in the absorber along the lengthwise direction such that the absorber is curved to be convex toward the outward direction. The disposable worn article diaper includes a crossing elastic member crossing the absorber in middle crotch regions and fixed to the absorber. The absorber is contracted by the crossing elastic member toward a center of the absorber in the widthwise direction.

Abstract: A male incontinence guard having a longitudinal extension defined between a first and a second end and a triangular base shape, the male incontinence guard comprising a liquid permeable top sheet, a liquid impermeable back sheet; an absorbent core, the absorbent core having straight longitudinal side edges; a side barrier at each longitudinal side edge of the absorbent core, each side barrier having an outer edge facing away from the respective longitudinal side edge of the absorbent core and an elastic fixed to at least the back sheet between the longitudinal side edge and the outer edge; wherein a distance between the elastics of the side barriers and the respective longitudinal side edge of the absorbent core in a direction perpendicular to the longitudinal side edge differs along the longitudinal direction.

Abstract: The present invention relates to a contact protection apparatus for covering a connection point of a medical fluid-conducting cassette for a medical fluid treatment, having at least one covering device for covering the connection point before the use of the cassette, and having at least one connection section for detachably connecting or holding the contact protection apparatus on the cassette. The present invention further relates to a medical fluid-conducting cassette having at least one contact protection apparatus according to the present invention.

Abstract: Air-in-line sensor systems and methods of using same are provided. In a general embodiment, the present disclosure provides an adapter including first and second cylindrical portions defining a fluid flow channel, the first cylindrical portion comprising two adjacent wedge-shaped protrusions. Each wedge-shaped protrusion is infrared transmittive and defines an outer surface and an inner surface. In another embodiment, an air-in-line sensor device includes a tube and an infrared reflective sensor having an infrared light emitter and an infrared light detector. The infrared light emitter and the infrared light detector are positioned at or near an adapter so that an infrared light can be transmitted to the adapter and at least a portion of the infrared light reflected off the adapter can be detected by the infrared light detector.

Abstract: The present disclosure provides a textured dilatation balloon that includes a balloon body having a proximal end, a distal end, and at least one indentation in the balloon body in an un-inflated state, wherein the balloon body comprises a continuous polymer tube with an external surface having at least one therapeutic agent disposed within the at least one indentation.

Abstract: Fluidic components, systems, and methods for use in ophthalmic surgeries are disclosed. In some embodiments, a fluidics cassette for use with an ophthalmic surgical console system is provided. The fluidics cassette includes a housing, a fluid passageway extending through the housing, a membrane positioned in fluid communication with the fluid passageway such that a fluid passing through the fluid passageway contacts the membrane, and an opening extending at least partially through the housing such that the opening is in communication with the membrane and is configured to be coupled to a vacuum source. When the vacuum source is coupled to the opening, fluid passing through the passageway is subjected to the vacuum generated by the vacuum source through the membrane to remove dissolved gasses from the fluid.

Abstract: A cannula for transferring a substance to and/or from a patient includes a tubular support sleeve and a transfer tube. The support sleeve includes a rigid tubular member defining a lumen extending from a proximal end to a distal end of the tubular member. The transfer tube is positioned in the lumen and extends beyond each of the proximal end and the distal end of the tubular member. The tubular member includes a rigid, MRI-compatible material.

Abstract: The instant application is directed to an assembly for a drug delivery device which is arranged to operate in two distinct modes, a priming mode starting from a pre-priming state and a dispense mode operating in a post-priming state, and a drug delivery device comprising this assembly. The assembly comprises a dose member, an actuating member and a piston rod which is configured to act on a bung of an assembled cartridge containing the drug. In the pre-priming state the actuating member is configured to be moved by a user such that the movement of the actuating member causes a movement of the dose member and such that the movement of the dose member causes a movement of the piston rod. In the post-priming state the dose member is configured to be moved by a user without causing a movement of the actuating member in order to perform a set and dispense action of the drug delivery device.

Abstract: A catheter for delivery of sclerosant to a tubular member or vein of the body to cause ablation. The catheter has one or more balloons located near the distal end to enhance effectiveness of the sclerosant and prevent its delivery to the deep venous system. The catheter has an orifice located near the distal end of the catheter to direct the sclerosant into the vessel and one or more effluent openings to provide for removal of the sclerosant fluid. A heating member such as an electrical resistance element, a Laser probe, or an RF electrode located within the catheter lumen or on the outside of the catheter shaft heats the sclerosant fluid to improve its ablation effectiveness.

Abstract: Methods, systems, and devices are disclosed for providing selective and non-selective cooling and warming of a patient. Multiple embodiments of devices are disclosed for performing rapid induction and maintenance of therapeutic hypothermia either in a hospital setting or in the field so that hypothermic treatment can be quickly instituted before significant tissue damage occurs. Methods are also disclosed for targeting brain cooling by irrigating the upper airway, aerodigestive tract, and/or more generalized cooling by irrigating the esophagus and/or stomach.

Abstract: A method and device for mixing substances to form a mixture that can he administered to a patient are disclosed. Such a device can include a hollow cylindrical member, a barrier sealing an opening of the member, and a tether attached to the barrier so that the harrier at least partially ruptures when the tether is pulled in a direction away from the barrier. Such a method for mixing substances can include providing a device with a first substance contained within the hollow cylindrical member. The method can also include the step of inserting the device into the barrel of an administering system, where the administering system includes a second substance, and the step of pulling the component in a direction away from the barrier such that the tether causes the barrier to at least partially rupture.

Abstract: A sacrificial catheter assembly and method of use for placing a functional catheter within the body of a patient, such as into the patient's vasculature, is disclosed. In one embodiment, the sacrificial catheter assembly comprises a sacrificial catheter including an elongate body that defines a longitudinally extending lumen. A stylet is removably received within the lumen of the sacrificial catheter such that the catheter and stylet can be advanced together to a target destination within the body of the patient. The sacrificial catheter is configured so as to then be proximally slid over the stylet to remove the sacrificial catheter from the body while the stylet remains in place at the target destination. A functional catheter can then be distally slid over the stylet to place the functional catheter at the target destination. The stylet can then be removed from the body of the patient.

Abstract: An antiseptic cap and packaging for use with a connector are provided. The antiseptic cap includes a material containing an antiseptic solution. Upon application of the cap to the connector, the material compresses thereby releasing the antiseptic solution. Packaging of the antiseptic cap typically includes a cap holder and a lid. A user could remove the cap from the cap holder before applying it to a connector. Alternatively, the cap holder may be used to apply the cap to the connector.