Patents Issued in June 6, 2013
  • CELLULOSIC GEL COMPOSITION WITH IMPROVED VISCOSITY STABILITY
    Publication number: 20130142837
    Abstract: The present invention is directed to cellulosic gel compositions having improved viscosity stability through the exclusion of particular antioxidants and/or the exclusion of chemical entities that tend to produce free radicals. Preferably, the composition is an ophthalmic cellulosic gel composition that is suitable as a multi-dose composition.
    Type: Application
    Filed: November 28, 2012
    Publication date: June 6, 2013
    Applicant: ALCON RESEARCH, LTD.
    Inventor: Alcon Research, Ltd.
  • COMPOSITIONS CONTAINING MICRONIZED TANAPROGET PREPARED BY WET GRANULATION
    Publication number: 20130142838
    Abstract: Compositions, preferably pharmaceutical compositions, containing micronized tanaproget, or pharmaceutically acceptable salt thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, butylated hydroxyanisole, povidone, and magnesium stearate, are provided. The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic to disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, and carcinomas and adenocarcinomas of the pituitary, endometrium, kidney, ovary, breast, colon, and prostate and other hormone-dependent tumors, and in the preparation of medicaments useful therefor. Additional uses include stimulation of food intake.
    Type: Application
    Filed: November 29, 2012
    Publication date: June 6, 2013
    Applicant: Wyeth LLC
    Inventor: Wyeth LLC
  • METHOD AND SYSTEM FOR ADDING SENSORY CONDITIONING CUES IN A PHARMACOTHERAPEUTIC REGIMEN
    Publication number: 20130142839
    Abstract: A method and system for administering pharmaceutical agents to a subject is provided. The system includes a course of treatment regimen, which includes a prescribed order of medicine amounts for periodic administration to the subject in the prescribed order. The amount of medicine includes a dose of at least one active pharmacological agent (APA) and an amount of at least one non-active pharmacological agent (NPA). The NPA provides at least one non-visual sensory cue. The dosage amounts of the APA contained within the amounts of medicine periodically administered in the prescribed order are varied within the course of treatment regimen, and the amount of the NPA contained within the amounts of medicine periodically administered in the prescribed order are held constant within the course of treatment regimen.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 6, 2013
    Inventors: Joshua D. Levine, Robert A. Levine
  • DENSE FIBRILLAR COLLAGEN MATRICES FOR TISSUE REPAIR AND THE PREPARATION METHOD THEREOF
    Publication number: 20130142840
    Abstract: Method for preparing a homogeneous collagen-based material by concentration of a collagen solution, includes bringing a collagen solution into contact by way of continuous injection and use of the material for tissue repair.
    Type: Application
    Filed: May 30, 2011
    Publication date: June 6, 2013
    Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE DE VERSAILLES SAINT QUENTIN EN YVELINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Marie-Madeleine Giraud-Guille, Nadine Nassif, Yan Wang, Christophe Helary, Anne Pelle
  • Calcium Carbonate Granulation
    Publication number: 20130142841
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Application
    Filed: January 30, 2013
    Publication date: June 6, 2013
    Applicant: DELAVAU L.L.C.
    Inventor: DELAVAU L.L.C.
  • Calcium Carbonate Granulation
    Publication number: 20130142842
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Application
    Filed: January 30, 2013
    Publication date: June 6, 2013
    Applicant: DELAVAU L.L.C.
    Inventor: Delavau L.L.C.
  • Calcium Carbonate Granulation
    Publication number: 20130142843
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Application
    Filed: January 30, 2013
    Publication date: June 6, 2013
    Applicant: DELAVAU L.L.C.
    Inventor: DELAVAU L.L.C.
  • TISSUE IMPLANTS FOR IMPLANTATION AND METHODS OF PREPARING THE SAME
    Publication number: 20130142844
    Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.
    Type: Application
    Filed: January 30, 2013
    Publication date: June 6, 2013
    Applicant: CRYOLIFE, INC.
    Inventor: CRYOLIFE, INC.
  • USE OF A COMBINATION OF AN OPIOID AGONIST AND AN OPIOID ANTAGONIST FOR THE TREATMENT OF CROHN'S DISEASE AND THE SYMPTOMS ASSOCIATED WITH CROHN'S DISEASE
    Publication number: 20130142845
    Abstract: The present invention is concerned with the use of combinations of opioid agonists and antagonists for treating Crohn's disease.
    Type: Application
    Filed: January 30, 2013
    Publication date: June 6, 2013
    Applicant: Euro-Celtique S.A.
    Inventor: Euro-Celtique S.A.
  • Modified Release Analgesic Suspensions
    Publication number: 20130142846
    Abstract: A pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.
    Type: Application
    Filed: January 31, 2013
    Publication date: June 6, 2013
    Applicant: MCNEIL-PPC, INC
    Inventor: MCNEIL-PPC, INC
  • S-ADENOSYLMETHIONINE FORMULATIONS WITH ENHANCED BIOAVAILABILITY
    Publication number: 20130142847
    Abstract: Provided herein are compositions and methods to enhance the absorption of S-adenosylmethionine (SAMe) and methods of treating various disorders or diseases using non-parenteral SAMe formulations with enhanced-absorption and improved bioavailability. In certain embodiments, the enhanced bioavailability formulations provided herein may be used to treat a variety of diseases or disorders, such as for example, psychiatric disorders including, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, depressive disorders (e.g. major clinical depression) and dysthymia; as well as treating liver disorders, cancer, autoimmune disorders, inflammatory disorders, joint disorders, gastrointestinal disorders and cardiovascular disease.
    Type: Application
    Filed: July 27, 2011
    Publication date: June 6, 2013
    Applicant: Methylation Sciences, Inc.
    Inventors: I. David MacDonald, Nancy Harrison, Aniko Takacs-Cox, Admir Purac, Almira Blazek-Welsh
  • PREPARATION FOR TREATMENT OF SPINAL CORD INJURY
    Publication number: 20130142848
    Abstract: The present invention is a solid sustained-release formulation comprising an agent for inhibiting semaphorin 3A as an active ingredient, which comprises an agent for inhibiting semaphorin 3A and pharmaceutically acceptable hardly water-soluble solid substance, in which the carrier is silicone.
    Type: Application
    Filed: August 4, 2011
    Publication date: June 6, 2013
    Inventors: Miho Maeda, Akiyoshi Kishino, Akihiko Sano, Hideyuki Okano, Masaya Nakamura, Liang Zhang
  • CONTROLLED RELEASE FORMULATIONS OF DRONEDARONE
    Publication number: 20130142849
    Abstract: The present invention relates to controlled release formulation of dronedarone or pharmaceutically acceptable salts, esters, metabolites, prodrugs or enantiomers thereof and controlled release polymers. The use of controlled release formulations of Dronedarone would improve the bioavailability and the patient compliance with reduction in number of dosages to be taken per day.
    Type: Application
    Filed: August 13, 2011
    Publication date: June 6, 2013
    Applicant: LUPIN LIMITED
    Inventors: Ashish Ashokrao Deshmukh, Pravin Meghrajji Bhutada, Sajeev Chandran, Shirish Kulkarni
  • ALLOPLASTIC INJECTABLE DERMAL FILLER AND METHODS OF USE THEREOF
    Publication number: 20130142850
    Abstract: A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided.
    Type: Application
    Filed: January 14, 2013
    Publication date: June 6, 2013
    Inventor: Ayman Boutros
  • Compositions Comprising Components Coated With a Liquid Impermeable but Gas Permeable Layer, Use Thereof for Treating Cutaneous and Other Exocrine Gland Diseases
    Publication number: 20130142851
    Abstract: The present invention relates to medically efficacious agents coated with substance that forms a liquid impermeable but gas permeable layer, the treatment of medical conditions therewith, and particularly medical conditions at least partially characterised by blockage or other malfunction of ducts of exocrine glands and especially ducts of sweat glands.
    Type: Application
    Filed: January 25, 2013
    Publication date: June 6, 2013
    Inventor: Warren Ward
  • NANOFIBER LAMINATE SHEET
    Publication number: 20130142852
    Abstract: A nanofiber laminate sheet including a layer of a nanofiber of a water insoluble polymer and a layer of a water soluble polymer containing a cosmetic component or a medicinal component. The nanofiber is preferably colored. The layer of a water soluble polymer is preferably a layer of a nanofiber of the water soluble polymer containing the cosmetic component or the medicinal component. The nanofiber laminate sheet is suited for use as a cosmetic sheet for makeup.
    Type: Application
    Filed: June 28, 2011
    Publication date: June 6, 2013
    Applicant: KAO CORPORATION
    Inventors: Takehiko Tojo, Masataka Ishikawa, Ritsuko Yamazaki, Yuko Yago, Motoaki Ito, Yoshimi Yamashita
  • Skin Cosmetic
    Publication number: 20130142853
    Abstract: The present invention is a skin cosmetic comprising agar hydrogel particles having an average particle size of 0.2-5 mm obtained by stirring and cooling, in an oil based solvent, an agar aqueous solution prepared such that the breaking stress after the cooling/solidification is 0.005-0.1 MPa and an oil based gel prepared by mixing fine particles of silicone that are three-dimensionally cross-linked chemically and silicone oil and/or hydrocarbon oil. The object of the present invention is to provide a cosmetic that gives a moderate massaging sensation at the time of use.
    Type: Application
    Filed: July 14, 2011
    Publication date: June 6, 2013
    Applicant: SHISEIDO COMPANY, LTD.
    Inventors: Akira Matsuo, Tomomi Furukawara
  • MANICURE COMPOSITION
    Publication number: 20130142854
    Abstract: Provided is a manicure composition of a French nail type which has less disturbance of the lines brought about by a base color and a topcoat and is quickly dried, which does not cause dew condensation on the coating film under a moist environment for coating and has less leveling and less irregular color and which is excellent in a drying property, an adhesive property, flexibility, a masking property, a finished property, a discharge performance and a restirring property. The above manicure composition comprises at least ethanol and propylene glycol monomethyl ether as a solvent, titanium oxide A having an average primary particle diameter of 200 to 400 nm, titanium oxide B having an average primary particle diameter of 10 to 80 nm, an acrylic resin, polyether-modified polydimethylsiloxane and a plasticizer.
    Type: Application
    Filed: August 30, 2011
    Publication date: June 6, 2013
    Inventors: Takayuki Hayakawa, Masaaki Morita
  • MODIFIED SOPHOROLIPIDS COMBINATIONS AS ANTIMICROBIAL AGENTS
    Publication number: 20130142855
    Abstract: A method to control, inhibit, and kill pathogens and normal microbial strains that includes, but not limited to plant, animal and human pathogens, biofilm forming microbes, biofouling microbes, algae, fungi, bacteria, virus and protozoa using natural SL, MSL derivative and combinations thereof encompassed by the combination invention.
    Type: Application
    Filed: February 2, 2013
    Publication date: June 6, 2013
    Applicant: Polytechnic Institute of New York University
    Inventor: Polytechnic Institute of New York University
  • COMPOSITIONS COMPRISING A GERMINANT AND AN ANTIMICROBIAL AGENT
    Publication number: 20130142856
    Abstract: The present invention provides an antiseptic composition comprising a germinant and an antimicrobial agent, wherein the germinant increases a pathogen's susceptibility to attack from the antimicrobial agent and wherein the antimicrobial agent does not inhibit the germinant. The present invention also provides an antiseptic wipe, handwash or paint comprising such antiseptic composition and a method of sterilizing a surface using such a composition.
    Type: Application
    Filed: February 15, 2011
    Publication date: June 6, 2013
    Applicant: INSIGHT HEALTH LIMITED
    Inventors: Tony Worthington, Laura Wheeldon
  • TOILET PAPER
    Publication number: 20130142857
    Abstract: The invention relates to toilet paper which can be used to satisfy human sanitary and hygiene requirements and makes it possible to reduce toilet paper consumption because the central sector of a sheet of the toilet paper has a higher average density and/or a higher average elasticity than the outer sector of said sheet of toilet paper, wherein the outer sector of the sheet of toilet paper completely or partially surrounds the central sector.
    Type: Application
    Filed: July 21, 2011
    Publication date: June 6, 2013
    Inventors: Vladimir Vitalievich Miroshnichenko, Vitaly Evgenievich Pilkin
  • DRUG DELIVERY DEVICES FOR DELIVERY OF OCULAR THERAPEUTIC AGENTS
    Publication number: 20130142858
    Abstract: Drug delivery devices comprising a non-bioabsorbable polymer structure configured to support a composition comprising an active agent. The devices include a plurality of portions fused together and a recess configured to support the composition. At least one of the portions includes an impermeable polymer and at least one other portion includes a rate-limiting water-permeable polymer. The rate-limiting water-permeable polymer allows for transportation of the active agent to an exterior of the device.
    Type: Application
    Filed: May 17, 2011
    Publication date: June 6, 2013
    Applicant: Aerie Pharmaceuticals, Inc.
    Inventors: Casey Kopczynski, Cheng-Wen Lin, Chris Sutay
  • COMPOSITIONS AND METHODS FOR THE SUSTAINED RELEASE OF BETA-ALANINE
    Publication number: 20130142859
    Abstract: Methods and compositions are provided for increasing the anaerobic working capacity of muscle and other tissues. Also provided are compositions formulated for the sustained release of free beta-alanine. Also provided is a dietary supplement formulated, for example, as a solid food product, an edible suspension, liquid or semi-liquid as described herein.
    Type: Application
    Filed: January 31, 2013
    Publication date: June 6, 2013
    Applicant: NATURAL ALTERNATIVES INTERNATIONAL, INC.
    Inventors: NATURAL ALTERNATIVES INTERNATIONAL, INC., Ken Wolf
  • MATERIAL COMPOSITIONS WHICH COMPRISE ADULT STEM CELLS OBTAINED FROM EXOCRINE GLANDULAR TISSUE, IN PARTICULAR FOR USE IN REGENERATIVE MEDICINE
    Publication number: 20130142860
    Abstract: The invention relates to material compositions comprising adult stem cells obtained from exocrine gland tissue and a supporting matrix having the shape of a thread structure and/or of a net. The supporting matrix preferably consists of a plastic material which is physiologically acceptable and degradable in the body. The material compositions of the invention are in particular suited for use in regenerative medicine, e.g. for regeneration of injured or damaged myocard tissue.
    Type: Application
    Filed: November 13, 2012
    Publication date: June 6, 2013
    Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG ANGEWANDTEN FORSCHUNG E.V.
    Inventor: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
  • Compositions And Method For Detecting And Treating Abnormal Liver Homeostasis And Hepatocarcinogenesis
    Publication number: 20130142861
    Abstract: Novel compositions and methods for detecting and preventing and/or treating abnormal liver homeostasis and hepatocarcinoma as well as conditions that may be regulated by microRNA-122 are provided. A transgenic knockout non-human animal comprising a disruption in the endogenous mir-122 gene is also provided.
    Type: Application
    Filed: November 29, 2012
    Publication date: June 6, 2013
    Applicant: NATIONAL YANG MING UNIVERSITY
    Inventor: National Yang Ming University
  • Tumor-Specific Delivery of Therapeutic Agents Via Liposomase
    Publication number: 20130142862
    Abstract: Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with C. novyi plus a single dose of liposomal doxorubicin. The secreted factor responsible for this phenomenon was identified and, surprisingly, proved to be a member of the lipase family. The gene encoding this protein, called liposomase, has the potential to be incorporated into diverse therapeutic methods to deliver specifically a variety of chemotherapeutic agents to tumors.
    Type: Application
    Filed: December 3, 2012
    Publication date: June 6, 2013
    Applicant: JOHNS HOPKINS UNIVERSITY
    Inventor: Johns Hopkins University
  • PHOSPHATIDYLCHOLINE LIPID LIPOSOMES AS BOUNDRY LUBRICANTS IN AQUEOUS MEDIA
    Publication number: 20130142863
    Abstract: The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.
    Type: Application
    Filed: June 16, 2011
    Publication date: June 6, 2013
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD., YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Jacob Klein, Ronit Goldberg, Yechezkel Barenholtz, Avi Schroeder
  • IN VIVO TARGETING OF DENDRITIC CELLS
    Publication number: 20130142864
    Abstract: The invention provides a composition for modulating immunity by the in vivo targeting of an antigen to dendritic cells. The composition comprises: a preparation of antigen-containing membrane vesicles or antigen-containing liposomes which have on their surfaces a plurality of metal chelating groups; and, a ligand for a receptor on the dendritic cells, the ligand being linked to a metal chelating group via a metal affinity tag on the ligand. The composition further includes an immunomodulatory factor. A process for preparing the composition is also provided. The invention further provides a method of modulating an immune disorder, and methods of treating tumours and infections.
    Type: Application
    Filed: December 28, 2012
    Publication date: June 6, 2013
    Applicant: Lipotek Pty Ltd.
    Inventors: Joseph Altin, Christopher Richard Parish
  • FIXED DOSING OF HER ANTIBODIES
    Publication number: 20130142865
    Abstract: The present invention concerns fixed dosing of HER antibodies, such as Pertuzumab.
    Type: Application
    Filed: January 18, 2013
    Publication date: June 6, 2013
    Applicant: GENENTECH, INC.
    Inventor: Genentech, Inc.
  • COMPOSITIONS AND METHODS FOR IMPROVED ORGAN TRANSPLANT PRESERVATION AND ACCEPTANCE
    Publication number: 20130142866
    Abstract: The invention provides a novel aqueous composition for the storage and preservation of transplants, such as organ or tissue allografts. The composition comprises the compound N-octanoyl dopamine in solubilised form. The composition may also be administered as a pre-treatment of transplant donors. Moreover, it may be used in transplant recipients, optionally in combination with immunosuppressants.
    Type: Application
    Filed: August 16, 2011
    Publication date: June 6, 2013
    Applicant: NOVALIQ GMBH
    Inventors: Bastian Theisinger, Sonja Theisinger, Bernhard Günther
  • CANCER-TARGETING PEPTIDES AND USES THEREOF IN CANCER TREATMENT AND DIAGNOSIS
    Publication number: 20130142867
    Abstract: Cancer-targeting peptides having a PX1LX2 motif, in which X1 is His or an amino acid residue with a hydrophobic side chain and X2 is Pro, Phe, or Trp. Also disclosed herein are conjugates containing the cancer-targeting peptides and uses thereof in cancer treatment and diagnosis.
    Type: Application
    Filed: October 25, 2011
    Publication date: June 6, 2013
    Applicant: Academia Sinica
    Inventors: John Yu, Alice L. Yu, H.C. Wu, I-Ju Chen, Sheng-Hung Wang
  • Circumferential Aerosol Device for Delivering Drugs to Olfactory Epithelium and Brain
    Publication number: 20130142868
    Abstract: Methods of delivering a pharmaceutical compounds directly to the olfactory epithelium of a mammal by providing a pharmaceutical aerosol suspension comprising an aerosol and the pharmaceutical compound; aerosolizing the suspension to generate a stream of droplets, the stream having a rotational component, and, delivering the droplets directly to the olfactory epithelium, wherein at least 15% of the droplets are delivered directly to the olfactory deposition. The pharmaceutical compound may be encapsulated within a liposome nanoparticle.
    Type: Application
    Filed: August 19, 2011
    Publication date: June 6, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: John D. Hoekman, Rodney J.Y. Ho
  • Compositions Comprising Non Steroidal Anti-inflammatory Drugs and Methods for Use Thereof
    Publication number: 20130142869
    Abstract: The invention provides analgesic, antipyretic and anti-inflammatory compositions containing epilactose in combination with non-steroidal anti-inflammatory drugs and pharmaceutically acceptable zinc compounds. This invention relates to the use of these novel compositions for significantly improved and synergistic safety and therapeutic profiles.
    Type: Application
    Filed: December 5, 2012
    Publication date: June 6, 2013
    Inventors: Phillip Alex, Ben Johns
  • NERAMEXANE MULTIPLE UNIT DOSAGE FORM
    Publication number: 20130142870
    Abstract: Unit comprising neramexane, a pharmaceutically acceptable salt, solvate, conjugate, prodrug, polymorphic form, isomer, or derivative thereof; and a release-controlling excipient; wherein said unit has a diameter of from 0.1 to less than 6 mm.
    Type: Application
    Filed: June 22, 2011
    Publication date: June 6, 2013
    Applicant: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Bernhard Hauptmeier, Brigitte Purmann
  • ORAL DOSAGE FORM OF DEFERASIROX
    Publication number: 20130142871
    Abstract: The invention relates to an oral dosage form containing deferasirox, binder, disintegrant and optionally wicking agent, wherein the introduction of the dosage form into water leads to a suspension wherein the suspended particles have an average particle size (D50) of 20 ?m to 120 ?m, and also to a method of producing it.
    Type: Application
    Filed: July 7, 2011
    Publication date: June 6, 2013
    Applicant: Ratiopharm GmbH
    Inventors: Jana Paetz, Katrin Rimkus
  • EMP2: Ethyl-Methyl, di Methyl, tri Methyl Pyruvate Acid Esters: A Tool for Regulating HbA1c and a Riboswitch Activator
    Publication number: 20130142872
    Abstract: The invention is a novel series of compounds represented by general formula, its analogs, tautomeric forms, stereoisomers, pharmaceutically acceptable salts and polymorphs wherein said compound described is a group of antisense molecules possessing immediate global cellular penetration due to their molecular structure and lipophilicity. The molecules are combinations of ethyl and methyl pyruvates. They induce riboswitch activity and reduce target RNA and nucleic acids such as HbA1c. They reduce inflammation and enhance energy production. These features improve therapeutic outcomes of diabetes, neuropathy and cellular aging.
    Type: Application
    Filed: August 9, 2012
    Publication date: June 6, 2013
    Inventors: John James Fitzgerald, JR., Ranya Ludwig Alexander, Anthony Joseph Meduri
  • PHARMACEUTICAL COMPOSITIONS OF 7-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-3-YL)-1-((TRANS)-4-METHOXYCYCLOHEXYL)-3,4-DIHYDROPYRAZINO [2,3-B]PYRAZIN-2(1H)-ONE, A SOLID FORM THEREOF AND METHODS OF THEIR USE
    Publication number: 20130142873
    Abstract: Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 6, 2013
    Applicant: SIGNAL PHARMACEUTICALS, LLC
    Inventor: Signal Pharmaceuticals, LLC
  • PHARMACEUTICAL COMPOSITIONS BASED ON DICLOFENAC
    Publication number: 20130142874
    Abstract: New pharmaceutical compositions for oral use containing Diclofenac together with alkali metal bicarbonates in amounts of from 20 to 80 by weight with respect to Diclofenac are described. These compositions are entirely palatable and free from any unpleasant taste or other side effects; in particular, these formulations permit to obtain in human patients higher Cmax of the active principle and shorter Tmax together with a lower coefficient of variation.
    Type: Application
    Filed: May 25, 2012
    Publication date: June 6, 2013
    Applicant: APR Applied Pharma Research SA
    Inventors: Alberto Reiner, Giorgio Reiner
  • METHODS AND COMPOSITIONS FOR TREATING PROSTATE CANCER
    Publication number: 20130142875
    Abstract: Treatment of prostate cancer by regional and prolonged release of one or more nucleotide-based RNAi agents is provided.
    Type: Application
    Filed: November 14, 2012
    Publication date: June 6, 2013
    Applicant: SILENSEED LTD.
    Inventor: SILENSEED LTD.
  • AMPHIPATHIC LIPID-BASED SUSTAINED RELEASE COMPOSITIONS
    Publication number: 20130142876
    Abstract: Chewable sustained release compositions and their methods of production are provided. The sustained release compositions contain amphipathic lipids, which are used to encapsulate various drugs and active ingredients.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 6, 2013
    Applicant: PEGASUS LABORATORIES, INC.
    Inventor: Pegasus Laboratories, Inc.
  • PHARMACEUTICAL DOSAGE FORM COMPRISING ONE OR MORE ANTIRETROVIRAL ACTIVE INGREDIENTS
    Publication number: 20130142877
    Abstract: The invention relates to a pharmaceutical dosage form comprising one or more antiretroviral active ingredients in the form of a solid dispersion or solid solution in a matrix, wherein said matrix comprises an amino(meth)acrylate copolymer, characterized in that the matrix does not contain any essential amounts of pharmaceutically acceptable surfactants with an HLB value from 12 to 18 and in that the matrix comprises a mono carboxylic acid or an alcohol with 12 to 22 carbon atoms or both.
    Type: Application
    Filed: March 3, 2011
    Publication date: June 6, 2013
    Applicant: EVONIK ROEHM GmbH
    Inventors: Pravin Nalawade, Smitha Shetty, Hema Ravishankar, Shripad Gadhinglajkar, Andreas Gryczke, Hans-Ulrich Petereit, Kathrin Nollenberger
  • PEPTIDE PARTICLE FORMULATION
    Publication number: 20130142878
    Abstract: A composition as disclosed is comprised of a plurality of groups of particles. The particles are comprised of a biocompatible polymer which may be a co-polymer such as PLGA combined with a peptide of a sequence of interest, e.g. a sequence which corresponds to a sequence presented on a surface of a cell infected with a virus. A plurality of different groups of particles are provided in the formulation wherein the particles within any single group include peptides of identical amino acid sequence. The particles are sized such that they are sufficiently large so as to prevent more than the contents of a single particle from being presented to a single immune system cell.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 6, 2013
    Applicant: FLOW PHARMA, INC.
    Inventor: FLOW PHARMA, INC
  • SUSPENSION FORMULATIONS
    Publication number: 20130142879
    Abstract: The present invention relates to suspension formulations, especially those for delivering a pharmaceutically active agent in aerosol form using a spray or aerosol device, such as a pressurised metered dose inhaler (pMDI). The formulations may be for pulmonary, nasal, buccal or topical administration, but are preferably for pulmonary inhalation.
    Type: Application
    Filed: January 29, 2013
    Publication date: June 6, 2013
    Applicants: INNOVATA BIOMED LIMITED, VECTURA LIMITED
    Inventors: VECTURA LIMITED, INNOVATA BIOMED LIMITED
  • BECLOMETHASONE DIPROPIONATE COMPOSITIONS IN MODIFIED-RELEASE GASTRO-RESISTANT MICROSPHERES AND PROCESS FOR OBTAINING THEM
    Publication number: 20130142880
    Abstract: The present invention refers to pharmaceutical beclomethasone dipropionate compositions in modified-release gastro-resistant microspheres and to their oral use in the treatment of inflammatory pathologies of the intestinal tract. Said compositions in microspheres comprise: a) a core consisting of a microsphere of inert material; b) a first intermediate coating comprising beclomethasone dipropionate and at least one physiologically acceptable excipient; c) a second modified-release gastro-resistant coating. The present invention also refers to a process for obtaining said compositions.
    Type: Application
    Filed: August 2, 2011
    Publication date: June 6, 2013
    Applicant: SOFAR SPA
    Inventor: Carla Labruzzo
  • Lip Balm Composition
    Publication number: 20130142881
    Abstract: A lip balm composition of natural ingredients, comprising : 54-70 wt. % of one or more oils, 22-28 wt. % beeswax, 3-4 wt. % propolis, 3-5 wt. % pomace, 0.02-3.2 wt. % antioxidant, and optional ingredients, whereby all components add to 100 wt. %.
    Type: Application
    Filed: December 2, 2011
    Publication date: June 6, 2013
    Applicant: THE MOTHERVINE NUTRACEUTICAL CO. LLC
    Inventor: Fountain ODOM
  • METHODS AND COMPOSITIONS FOR TREATMENT, MODIFICATION AND MANAGEMENT OF BONE CANCER PAIN
    Publication number: 20130142882
    Abstract: The present invention provides methods and compositions for treating, preventing, modifying (reducing), or managing bone cancer pain by cyclohexenone compounds.
    Type: Application
    Filed: November 14, 2012
    Publication date: June 6, 2013
    Applicant: GOLDEN BIOTECHNOLOGY CORPORATION
    Inventor: GOLDEN BIOTECHNOLOGY CORPORATION
  • MEDICAL FOOD FOR THE DIETARY MANAGEMENT OF DEPRESSION AND ANXIETY AND METHODS THEREOF
    Publication number: 20130142883
    Abstract: A medical food for the dietary management of depression and/or anxiety includes water containing from 0.0002 to 0.0278 mol. % of isotopologue HOD, preferably, from 0.0178 to 0.0278 mol. % of isotopologue HOD. Further, a method for the dietary management of depression and/or anxiety uses the step of administering to a subject in need thereof the medical food. Further, a method of the treatment of depression includes the steps of administering to a subject an antidepressant drug and administering to the subject the medical food. Further, a method of the treatment of anxiety includes the steps of administering to a subject an antianxiety drug and administering to the subject the medical food.
    Type: Application
    Filed: November 27, 2012
    Publication date: June 6, 2013
    Inventors: Igor Anatolyevich Pomytkin, Anton Sergeevich Chernopyatko
  • Cream for Applying on a Body
    Publication number: 20130142884
    Abstract: A cream has at least two components, one of the components includes stable water clusters, and the cream is applied on a body to produce local surface effects, local deep effects, and non-local effects in the body.
    Type: Application
    Filed: January 28, 2013
    Publication date: June 6, 2013
    Applicant: D & Y Laboratories
    Inventor: D & Y Laboratories
  • IMMOBILIZED METALLIC NANOPARTICLES AS UNIQUE MATERIALS FOR THERAPEUTIC AND BIOSENSOR APPLICATIONS
    Publication number: 20130142885
    Abstract: The present invention relates to compositions and methods by which surface modification techniques can be used to modify wide range polymeric or metal substrates using metal nanoparticles.
    Type: Application
    Filed: January 15, 2013
    Publication date: June 6, 2013
    Applicant: University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Venture Group
    Inventor: University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Ventures Group
  • COMPOSITIONS OF DIBROMOMALANOMIDE AND THEIR USE AS BIOCIDES
    Publication number: 20130142886
    Abstract: A biocidal composition comprising 2,2-dibromomalonamide and a metal selected from silver, copper, and mixtures thereof, and its use for the control of microorganisms in aqueous and water-containing systems.
    Type: Application
    Filed: August 3, 2011
    Publication date: June 6, 2013
    Applicants: DOW GLOBAL TECHNOLOGIES LLC, ROHM AND HAAS CHEMICALS LLC
    Inventors: Freddie L. Singleton, Tirthankar Ghosh, Kimberly S. Cagle