Abstract: A method of synthesizing carboxylated amines is disclosed. The method comprises reacting a mixture of a potassium salt of either a primary or secondary amine with a potassium salt of a halogenated carboxylic acid wherein the halogenated carboxylic acid is selected from the group consisting of brominated, chlorinated, or iodinated carboxylic acid in the presence of potassium hydroxide, and optionally in heating the reacting mixture; precipitating the potassium salt by optionally chilling the mixture and discarding the precipitate; purifying the carboxylate amine potassium salt from the liquid phase using water soluble alcohol and optionally adding formic acid to obtain the free aminocarboxylic acid and potassium formate. In a preferred embodiment, the halogenated carboxylic acid is chloroacetic acid.

Abstract: The present invention generally relates to processes for the chemocatalytic conversion of a carbohydrate source to an adipic acid product. The present invention includes processes for the conversion of a carbohydrate source to an adipic acid product via a furanic substrate, such as 2,5-furandicarboxylic acid or derivatives thereof. The present invention also includes processes for producing an adipic acid product comprising the catalytic hydrogenation of a furanic substrate to produce a tetrahydrofuranic substrate and the catalytic hydrodeoxygenation of at least a portion of the tetrahydrofuranic substrate to an adipic acid product. The present invention also includes products produced from adipic acid product and processes for the production thereof from such adipic acid product.

Abstract: A process for the reduction and/or removal of permanganate reducing compounds formed by the carbonylation of methanol in the presence of a Group VIII metal carbonylation catalyst to produce acetic acid is disclosed. More specifically, a process for reducing and/or removing permanganate reducing compounds or their precursors from intermediate streams during the formation of acetic acid by said carbonylation processes is disclosed. In particular, a process in which a low boiling overhead vapor stream from a light ends column is subjected to a single distillation to obtain an overhead that is subjected to an extraction to selectively remove and/or reduce PRC's from the process is disclosed.

Abstract: The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).

Abstract: The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compounds and methods of treating diseases using the compounds.

Abstract: The invention relates to a process for the preparation of intermediates useful in the preparation of fungicidally active phenylpropargylether derivatives. The process involves coupling of carboxylic acid with an amine in (a) the absence of a catalyst; (b) the presence of a boronic acid catalyst.

Abstract: The compound of formula (I) is a water-stable, long acting ?2-selective adrenoceptor agonist useful as a bronchodilator in the treatment of bronchoconstriction associated with reversible obstructive airways diseases and the like.

Abstract: The present invention provides new ?-phenylethylidenehydrazine derivatives, processes for preparing them and their use as pharmaceutical compostions.

Abstract: The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method.

Abstract: The present invention discloses both amine compositions and amine-epoxy compositions containing N,N?-dimethyl-meta-xylylenediamine. A novel process for producing amines such as N,N?-dimethyl-meta-xylylenediamine, and structurally similar amines, is also disclosed.

Abstract: A method for producing a polyoxyalkylene derivative represented by the following general formula (1): Z(OA)n-OH]m??(1) wherein Z is a residue of glycerin or diglycerin, OA is an oxyalkylene group having 2 to 4 carbon atoms, n is an average number of moles of the oxyalkylene group added and is 80 to 800, and m is 3 to 4, the method comprising steps (A), (B), (C), (D), (E), and (F) defined in the present description.

Abstract: The process provided herein is concerned with recovery of hydrocarbons from sulfones using an individual alkali and alkaline-earthy base and a mixture of thereof. As the starting materials are sulfones generated by ODS and commercially inexpensive alkali and alkaline-earth bases, the cost and ecological impact of solid waste disposal is minimized.

Abstract: Methods and systems for the hydroxylation of olefenic alcohols are described herein. The methods and systems incorporate the novel use of a high shear device to promote mixing and solubility of peroxides with the olefenic alcohol. The high shear device may allow for lower reaction temperatures and pressures and may also reduce hydroxylation time with existing catalysts.

Abstract: Process for the conversion of ethanoic acid into ethanol by (a) introducing ethanoic acid and H2 into a primary hydrogenation unit in the presence of a precious metal-based catalyst to produce ethanol and ethyl ethanoate and (b) introducing ethyl ethanoate, from step (a), together with H2 into a secondary hydrogenation unit in the presence of a copper-based catalyst to produce ethanol. Ethanol from step (b) is recovered.

Abstract: Provided is an immersion oil for microscope including a liquid olefin polymer (A), a liquid diene polymer (B), a diaryl alkane (C), and an alkyl benzene (D), the immersion oil for microscope being capable of maintaining low fluorescence of its own over a long period of time, having good characteristics required for an immersion oil for microscope, such as good refractive index, Abbe number, viscosity, and resolution, and being particularly suitable as an immersion oil for a fluorescence microscope.

Abstract: A lignocellulosic biomass material is converted into precursors for liquid hydrocarbon transportation fuels by contacting the biomass material with water and carbon monoxide at elevated temperature, typically from 280 to 350° C., an elevated pressure, typically a total system pressure of 12 to 30 MPa and a CO partial pressure from 5 to 10 MPa and a weight ratio of water:biomass material from 0.5:1 to 5.0:1, to dissolve the biomass material into the reaction mixture and depolymerize, deoxygenate and hydrogenate the lignocellulose biomass material, so converting the biomass material into liquid transportation fuel precursors.

Abstract: Process for evaluating the effect of a refinery feedstock on a refinery process by (i) providing a refinery feedstock (ii) treating the refinery feedstock to produce a plurality of fractions each representative of a feedstock for the refinery process, the plurality of fractions having at least two fractions with different properties; (iii) treating each of the plurality of fractions under experimental conditions representative of those in the refinery process, the treatments being carried out in an essentially parallel manner; and (iv) determining one or more performance criteria for each fraction for the refinery process by analyzing the respective product streams produced from each fraction at least partially in parallel.

Abstract: A method for producing a linear paraffin product from natural oil and kerosene includes providing a first feed stream comprising kerosene, pre-fractionating the first feed stream to produce a heart cut paraffin stream comprising paraffins in a heart cut range, and combining the heart cut paraffin stream with a second feed stream comprising natural oil to form a combined stream. The method further includes deoxygenating the natural oil and fractionating the combined stream to remove paraffins that are heavier than the heart cut range.

Abstract: A process for the dimerization of isoolefins is disclosed. The process may include: contacting an isoolefin with sulfurous acid in a reaction zone at conditions of temperature and pressure sufficient to dimerize at least a portion of the isoolefin.

Abstract: The invention provides processes for generating a methane-enriched gas from a gas mixture comprising carbon monoxide and hydrogen such as gas streams generated by gasification of an alkali metal catalyst-loaded carbonaceous feedstock, and a char methanation catalyst useful in such processes.

Abstract: A process of producing PX comprising providing a C8+ feedstock, the C8+ feedstock has C8 hydrocarbons and C9+ hydrocarbons, to a crystallization unit under crystallization conditions to produce a PX enriched stream having a PX concentration of at least 99.5 wt % based on the weight of the PX enriched stream, wherein the C8+ feedstock has a PX concentration of at least 70 wt % based on total weight of xylenes in the C8+ feedstock, which the C8+ feedstock having a C9+ hydrocarbons concentration in a range from 1 wppm to 10 wt % based on the total weight of the C8+ feedstock.

Abstract: A matrix material for safe temporary and/or ultimate disposal of radioactive wastes suitable for the embedment of radioactive wastes, contains graphite and at least inorganic binder which can be glass, aluminosilicate, silicate, borate and lead sulfide.

Abstract: A potty training readiness indicator, which can be utilized in a disposable absorbent article, having at least one indicating member. The potty training readiness indicator which indicates to the caregiver when the wearer is ready to be potty trained.

Abstract: An absorbent article according to the present invention includes: a water-decomposable top sheet, a water-decomposable back sheet; and a water-decomposable absorber placed between the top sheet and the back sheet. The back sheet is formed of multiple sheet pieces each being smaller than a main body of the absorbent article, and each sheet piece at least partially overlapping adjacent one or more of the other sheet pieces. In addition, an adhesive is applied to each overlapping region where adjacent two of the sheet pieces overlap each other.

Abstract: An absorbent layer containing water-absorbing polymeric particles that are surface-treated and that are immobilized by a matrix, formed from a thermoplastic adhesive component, including a thermoplastic polymers and a specific plasticizer, and being free of low weight average molecular weight (e.g. below 1000, or below 2000 or even below 3000 g/mole) tackifiers and plasticizers. The absorbent articles may for example be adult incontinence articles, infant (e.g. baby, toddler) diapers, including training pants, and feminine hygiene articles, such as sanitary napkins.

Abstract: An absorbent article that can be a sanitary napkin. The absorbent article comprises a topsheet joined to a backsheet and has an absorbent core material disposed therebetween, the absorbent core material being a fibrous absorbent material exhibiting on one side thereof discrete raised portions. The raised portions define a continuous network of channels, the channels defining a void region adjacent the topsheet of the sanitary napkin.

Abstract: The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.

Abstract: A method induces cancer, such as ovarian cancer, in primates for testing of therapeutic treatments and preclinical research and development. A nanoparticle delivers plasmid DNA encoding oncogenes and siRNAs for tumor suppressor genes. For example, a biocompatible polymer, chitosan, is complexed with three plasmids including one that carries the cDNA encoding RAS oncogene and two plasmids encoding siRNAs for two tumor supressor genes p53 and Rb. Laproscopic delivery of these nanoparticles to the ovaries of non-human primates causes ovarian carcinoma, which is detected one month after delivery of the nanoparticles.

Abstract: The invention provides transgenic animals having a transgene comprising a genomic human alpha synuclein segment including six exons, five introns and at least one mutation associated with synucleinopathic disease operably linked to a human alpha synuclein promoter. The transgenic animals have characteristics of synucleinopathic disease including elevated levels of alpha synuclein in the brain, formation of intracellular deposits of alpha synuclein that have at least one, and preferably all features of Lewy bodies, formation of alpha-synuclein fragments, or phosphorylated forms of alpha synuclein, loss of neuronal cells, glial cells or oligodentricytes, impairment of motor function and/or impairment of cognitive function.

Abstract: The present disclosure describes an animal model of central neuropathic pain relevant to spinal cord injury, as well as methods of using the model to screen for therapeutic agents and to test existing therapies.

Abstract: A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.

Abstract: A method for increasing production of hybrid seed of bee-pollinated crops, such as alfalfa and soybean at predetermined hybridity levels. Hybrid seed is produced using female and pollenizer plants at a selected ratio of female plants to pollenizer plants. The female plants and the pollenizer plants are intermingled in the hybrid seed production field. Prediction of percentage of hybridity at various female to pollenizer ratios allows for selection of a ratio of female plants to pollenizer plants to provide seed at a test percentage of hybridity. The percentage of hybridity may be increased post-harvest by employing techniques using seed properties such as size differential, color or density to remove a higher percentage of non-hybrid seed. The hybrid seed product is maximized at various hybridity levels. Planting according to subrows allows for separate harvesting of intermingled crops. Testing the hybrid seed product provides verification of percentage of hybridity.

Abstract: A novel maize variety designated X03B509 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X03B509 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X03B509 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X03B509, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X03B509. This invention further relates to methods for producing maize varieties derived from maize variety X03B509.

Abstract: According to the invention, there is provided seed and plants of the hybrid corn variety designated CH157635. The invention thus relates to the plants, seeds and tissue cultures of the variety CH157635, and to methods for producing a corn plant produced by crossing a corn plant of variety CH157635 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH157635.

Abstract: According to the invention, there is provided seed and plants of the hybrid corn variety designated CH533378. The invention thus relates to the plants, seeds and tissue cultures of the variety CH533378, and to methods for producing a corn plant produced by crossing a corn plant of variety CH533378 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH533378.

Abstract: According to the invention, there is provided seed and plants of the hybrid corn variety designated CH355160. The invention thus relates to the plants, seeds and tissue cultures of the variety CH355160, and to methods for producing a corn plant produced by crossing a corn plant of variety CH355160 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH355160.

Abstract: The invention provides seed and plants of sweet corn hybrid SEY6RH1263 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of sweet corn hybrid SEY6RH1263 and the parent lines thereof, and to methods for producing a sweet corn plant produced by crossing such plants with themselves or with another sweet corn plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the parts of such plants.

Abstract: The invention provides seed and plants of sweet corn hybrid SEY6RH1264 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of sweet corn hybrid SEY6RH1264 and the parent lines thereof, and to methods for producing a sweet corn plant produced by crossing such plants with themselves or with another sweet corn plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the parts of such plants.

Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein, enhanced seed oil and modified oil composition. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.

Abstract: The present invention relates to a new plant breeding process. The process improves the agronomic performance of crop plants by using genetic material that is also used in classical breeding. Instead of sexually recombining entire genomes at random, as is done in classical breeding, specific genetic elements are rearranged in vitro and inserted back into individual plant cells. Plants obtained through this new plant breeding process do not contain foreign nucleic acid but only contain nucleic acid from the plant species selected for transformation or plants that are sexually compatible with the selected plant species. Plants developed through this new plant breeding process are provided. In particular, potato plants displaying improved tuber storage and health characteristics are provided.

Abstract: The invention relates to the soybean variety designated A1023487. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1023487. Also provided by the invention are tissue cultures of the soybean variety A1023487 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1023487 with itself or another soybean variety and plants produced by such methods.

Abstract: A novel soybean variety, designated XB29Z11 is provided. Also provided are the seeds of soybean variety XB29Z11, cells from soybean variety XB29Z11, plants of soybean XB29Z11, and plant parts of soybean variety XB29Z11. Methods provided include producing a soybean plant by crossing soybean variety XB29Z11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB29Z11, methods for producing other soybean varieties or plant parts derived from soybean variety XB29Z11, and methods of characterizing soybean variety XB29Z11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB29Z11 are further provided.

Abstract: A novel soybean variety, designated XB32AR11 is provided. Also provided are the seeds of soybean variety XB32AR11, cells from soybean variety XB32AR11, plants of soybean XB32AR11, and plant parts of soybean variety XB32AR11. Methods provided include producing a soybean plant by crossing soybean variety XB32AR11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB32AR11, methods for producing other soybean varieties or plant parts derived from soybean variety XB32AR11, and methods of characterizing soybean variety XB32AR11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB32AR11 are further provided.

Abstract: A novel soybean variety, designated XR35AN11 is provided. Also provided are the seeds of soybean variety XR35AN11, cells from soybean variety XR35AN11, plants of soybean XR35AN11, and plant parts of soybean variety XR35AN11. Methods provided include producing a soybean plant by crossing soybean variety XR35AN11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XR35AN11, methods for producing other soybean varieties or plant parts derived from soybean variety XR35AN11, and methods of characterizing soybean variety XR35AN11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XR35AN11 are further provided.

Abstract: A soybean cultivar designated 14333215 is disclosed. The invention relates to the seeds of soybean cultivar 14333215, to the plants of soybean cultivar 14333215, to the plant parts of soybean cultivar 14333215, and to methods for producing progeny of soybean cultivar 14333215. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 14333215. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 14333215, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 14333215 with another soybean cultivar.

Abstract: A soybean cultivar designated 11374861 is disclosed. The invention relates to the seeds of soybean cultivar 11374861, to the plants of soybean cultivar 11374861, to the plant parts of soybean cultivar 11374861, and to methods for producing progeny of soybean cultivar 11374861. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 11374861. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 11374861, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 11374861 with another soybean cultivar.

Abstract: A soybean cultivar designated 18172925 is disclosed. The invention relates to the seeds of soybean cultivar 18172925, to the plants of soybean cultivar 18172925, to the plant parts of soybean cultivar 18172925, and to methods for producing progeny of soybean cultivar 18172925. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 18172925. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 18172925, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 18172925 with another soybean cultivar.

Abstract: A soybean cultivar designated 16352100 is disclosed. The invention relates to the seeds of soybean cultivar 16352100, to the plants of soybean cultivar 16352100, to the plant parts of soybean cultivar 16352100, and to methods for producing progeny of soybean cultivar 16352100. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 16352100. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 16352100, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 16352100 with another soybean cultivar.

Abstract: A soybean cultivar designated 13203100 is disclosed. The invention relates to the seeds of soybean cultivar 13203100, to the plants of soybean cultivar 13203100, to the plant parts of soybean cultivar 13203100, and to methods for producing progeny of soybean cultivar 13203100. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 13203100. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 13203100, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 13203100 with another soybean cultivar.

Abstract: The invention provides seed and plants of the bean line designated FIVC6V0998. The invention thus relates to the plants, seeds and tissue cultures of bean line FIVC6V0998, and to methods for producing a bean plant produced by crossing a plant of bean line FIVC6V0998 with itself or with another bean plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of bean line FIVC6V0998, including the pods and gametes of such plants.