Abstract: The invention relates to compositions and methods for controlling amaranth by application of at least one PPO inhibitor and gibberellic acid to an area in need of weed control.

Abstract: Many herbicidal compositions have been developed and are presently used. However, weeds to be controlled are various in types and their emergence extends over a long period. Accordingly, it is desired to develop a herbicidal composition which has a broader herbicidal spectrum, a high activity and a long-lasting effect. The present invention provides a herbicidal composition comprising, as active ingredients, (a) flazasulfuron or its salt and (b) metribuzin or its salt.

Abstract: The present invention relates generally low volatility herbicidal compositions comprising at least one auxin herbicide and at least one monocarboxylic acid, or monocarboxylate thereof. The invention further relates generally to methods for preparing and using such low volatility herbicidal compositions, including methods for controlling auxin-susceptible plant growth on agricultural and non-agricultural lands.

Abstract: The invention relates to compositions that contain A) one or more copolymers, said copolymers containing one or more structural units obtained from a) 19.9 to 75.9 wt. % glycerin, b) 0.1 to 30 wt. % at least one dicarboxylic acid, and c) 24 to 80 wt. % at least one monocarboxylic acid according to formula (I) R1—COOH (I), in which R1 is (C5-C29)-alkyl; (C7-C29)-alkenyl; phenyl; or naphthyl, and B) one or more solvents that are not miscible with water. The invention is characterized in that said compounds either do not contain water or contain water in a quantity less than or equal to 1.0 wt. % with respect to the total weight of the respective composition. The compositions are advantageously suitable for producing pesticide compositions for example.

Abstract: In a herbicidal composition containing a sulfonylurea compound of the formula (I): a carboxymethylcellulose salt, a ligninsulfonic acid salt, a surfactant and water, growth of particle of the sulfonylurea compound suspended in the herbicidal composition scarcely occurs after the storage.

Abstract: An open type nuclear magnetic resonance magnet system having an iron ring member. A superconducting coil and a superconducting switch form a closed-loop current circuit to generate a magnetic field. The generated magnetic field gains a magnetic flux circuit and executes magnetic field shielding through upper and lower iron yokes and a lateral iron yoke. The magnet system generates a desired magnetic field in a magnet imaging central area via the superconducting coil. To balance the extremely high electromagnetic force between the superconducting coil and the upper and lower iron yokes, an annular iron ring is mounted in a space defined by an inner perimeter wall of in a cryogenic container. The magnetic field distribution between the superconducting coil and the upper and lower iron yokes is changed via the iron ring, so that the electromagnetic interaction force therebetween is reduced.

Abstract: The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.

Abstract: The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.

Abstract: The invention is a method of determining nucleotide sequence of a target nucleic acid using microarray analysis. Hybridization signals from probe sets corresponding to the sense and anti-sense strands are compared at each nucleotide position. If there is a substantial difference in performance between the two strands, probe sets from a poorly performing stand are eliminated from the sequence determination calculation for a particular nucleotide.

Abstract: Provided is an assay method using an encoded particle-based platform. In the assay method, first, a plurality of encoded particles having codes distinguishable from one another according to kinds of included target materials are prepared. The plurality of encoded particles are provided onto a plate including a plurality of wells by pipetting, and disposed in the plurality of wells by a self-assembly method. An analyte is provided into the plurality of wells. The codes of the plurality of encoded particles disposed in the plurality of wells are decoded. The target materials of the plurality of encoded particles are released to cause a reaction between the target materials and the analyte.

Abstract: Provided are a method for retaining in a dormant state a cancer tissue-derived cell mass that can reflect accurately the in vivo behavior of cancer cells, and an evaluation method for examining the sensitivity to various treatments including a drug sensitivity test by using a cancer tissue-derived cell mass in such a dormant state. The cancer tissue-derived cell mass is prepared from an individual. Such a cancer tissue-derived cell mass is cultured in vitro under the conditions of hypoxia and low levels of growth factors. Furthermore, a treatment with a drug, etc. is applied in vitro to the cancer tissue-derived cell mass in the dormant state so that evaluation is achieved by examination of its proliferation state, determination of life and death, and analysis of signals.

Abstract: Materials and methods for using combinations of metabolic syndrome and HPA axis biomarkers for monitoring major depressive disorder.

Abstract: Methods for detecting and identifying microorganisms in a biologic sample are provided. The methods utilize identifying rRNA from microorganisms to both show the presence and identity for the majority of infectious agents present in clinical samples. The methods are preferably adapted for use in a clinical setting.

Abstract: A method of binding a protein to its encoding nucleic acid is disclosed wherein the method of binding is non-covalent at one or more locations between the protein and the encoding nucleic acids.

Abstract: Methods, devices, and kits for diagnosing or evaluating irritable bowel syndrome employ an analysis for the presence and amount of specific cytokines. The levels of such cytokines provide an index for diagnosis and/or evaluation of therapeutic response. Samples to be tested include peripheral blood, serum, plasma, or tissue from a human subject having or suspected of having Irritable Bowel Syndrome.

Abstract: The invention discloses a method for identifying a subset of polynucleotides from an initial set of polynucleotides corresponding to the human genome for the in vitro determination of severity of the host response of a patient having a severe infectious and/or inflammatory condition, in a sample, a measuring device comprising a plurality of different gene probes which represent the entire human genome, the test persons, depending on their infectious and/or inflammatory status, are divided into at least two clinically determined phenotype groups, changes of the gene expression signals between the phenotype groups are compared statistically, and gene probes are selected based on the gene expression signals which have significantly changed statistically between at least two phenotype groups.

Abstract: The present invention relates to uniform nanostructure biosensors and methods of calibrating the response of nanostructure biosensors. The invention overcomes device to device variability that has made quantitative detection difficult. The described biosensors have uniform characteristics that allow for more reliable comparison across devices. The methods of the invention comprise normalizing the initial current rate, as measured by the nanostructure biosensor following the addition of an analyte, to device characteristics of the biosensor. The device characteristics of the biosensor which can be used to normalize the response include baseline current and transconductance. Calibration of responses allows for the generation of calibration curves for use in all devices to quantitatively detect an analyte, without the need for individual device calibration.

Abstract: Methods of detecting influenza, including differentiating between type and subtype are disclosed, for example to detect, type, and/or subtype an influenza infection. A sample suspected of containing a nucleic acid of an influenza virus, is screened for the presence or absence of that nucleic acid. The presence of the influenza virus nucleic acid indicates the presence of influenza virus. Determining whether the influenza virus nucleic acid is present in the sample can be accomplished by detecting hybridization between an influenza specific probe, influenza type specific probe, and/or subtype specific probe and an influenza nucleic acid. Probes and primers for the detection, typing and/or subtyping of influenza virus are also disclosed. Kits and arrays that contain the disclosed probes and/or primers also are disclosed.

Abstract: The present invention provides methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.

Abstract: The present disclosure provides a cover sheet for a microarray reaction device. In one aspect, the present cover sheet or device ensures the reaction units/volumes are stable and/or consistent among assay samples and assay runs, allowing samples (e.g., reaction solutions) to be conveniently added and distributed uniformly.

Abstract: The invention provides biomarkers associated with age related immune function and the use of the biomarkers to identify compositions useful for strengthening immune function in animals and to determine if an animal is responding to treatment targeted to strengthen the immune system.

Abstract: Provided herein is a method of detecting cancer through generalized loss of stability of epigenetic domains as well as compositions useful therein. The present invention is based on the discovery that generalized loss of stability of epigenetic domains was determined to be a characteristic across various cancer types. Genome-scale bisulfite sequencing of cancers revealed a surprising loss of methylation stability in the cancer methylome, involving both CpG islands and shores, as well as large (up to several megabases) blocks of hypomethylation affecting more than half of the genome, with concomitant stochastic variability in gene expression.

Abstract: Provided are methodology, compositions and kits to prevent and treat diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, using processed lysyl oxidase or lysyl oxidase-like protein inhibitors, LOX inhibitors and LOXL inhibitors, or synergistic combinations of such inhibitors with therapeutic agents. Provided are methods for selecting tumor invasion, angiogenesis and metastasis inhibiting agents, by contacting cells in EMT states with candidate agents and detecting changes in such states; and methods, compositions, and kits for diagnosing or monitoring diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, using molecules or agents specifically recognizing processed LOX or LOXL. Provided are methods, compositions, medical devices, systems and kits for preventing or treating diseases and conditions associated with fibrosis, including pathological cardiovascular conditions and diseases, e.g.

Abstract: This invention provides methods and devices for the high-throughput characterization of the mechanical properties of cells or particles. In certain embodiments the devices comprise a microfluidic channel comprising: an oscillating element on a first side of said channel; and a detecting element on a second side of said channel opposite said oscillating element, wherein said detecting element is configured to detect a force transmitted through a cell or microparticle by said oscillating element. In certain embodiments the devices comprise a microfluidic channel comprising an integrated oscillator and sensor element on one first side of said channel, wherein said sensor is configured to detect a force transmitted through a cell or microparticle by said oscillator.

Abstract: The present disclosure refers to a method for a specific, versatile and sensitive detection of IFN-/virus-induced genes, a method for quantifying IFN potency and activity in a pharmaceutical preparation or biological sample, a method for distinguishing between IFN- and viral induction, and/or for distinguishing between different viruses, and a method for the quantification of virus activity. Also, the invention provides the necessary molecular tools like expression active response constructs, suitable cell lines, an array to perform the method and a kit.

Abstract: A system allows for rapid and specific induction of individual genes in eukaryotic cells using a chimeric transcriptional activator that is responsive to hormone inducer. Upon addition of the hormone, cytoplasmic transcriptional activator localizes to the nucleus and subsequently binds to promoters containing sequences that bind to its DNA-binding domain. Genetic modifications allow for rapid and specific degradation of a targeted protein upon addition of hormone by means of a regulated degron method that utilizes a protease variant. This system is useful for discovering new compounds by high throughput screening when introducing compound libraries to these protein-depleted cells.

Abstract: A sensor device has an arrangement of plural sensors for sensing an analyte which is in at least one of liquid phase or a suspension or a gel. Each sensor includes a nano-electrode and is configured to sense the presence of a particle localized to or bound to the nano-electrode. The sensor is configured to discriminate in real-time the binding of particles to respective nano-electrodes.

Abstract: The invention encompasses methods of modulating body fat or weight loss. In addition, the invention encompasses arrays that comprise biomolecules associated with an obese host microbiome or a lean host microbiome.

Abstract: The invention concerns a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule (e.g. a biological target) and further comprising an oligonucleotide (b) or functional analogue thereof. In a first embodiment according to the invention, the chemical compound is characterized in that the oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1?) of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q).

Abstract: Disclosed are compositions and methods for the preparation of RNA libraries for sequencing, gene expression profiling, microarray and other uses and for simplification of the library preparation process. The disclosure provides blocking oligonucleotides which bind to byproduct nucleic acid molecules formed during the ligation of adapters to nucleic acid segments prior to sequencing and inhibit or block amplification of the byproduct nucleic acid molecules in subsequent amplification reactions. Methods for library preparation using blocking oligonucleotides are also provided.

Abstract: Described herein is a thermostable enzyme capable of efficient ligation of two oligomers at high temperature. The embodiments herein have led to the development of an optimized ligation step used in library preparation for sequencing reactions.

Abstract: Device to detect at least an analyte, comprising a transparent substrate (2), having a first surface (3) with which a light source (7) is associated, and a second surface (4) on which a plurality of biological protein probes (12) are disposed, a layer (6) of polymer being interposed between said second surface (4) and said biological protein probes (12). A marker (fluorophore) is associated with said analyte, having determinate characteristics of fluorescence and/or phosphorescence correlated to the emission wavelength of the light source (7). Said light source (7) is suitable to emit a light radiation in a range of wavelengths equal to 400-550 nm, inside which range the absorption peak of said marker (fluorophore) used is comprised. The value of the distance (“s”) between the wavelength corresponding to the absorption peak of the marker (fluorophore) and the wavelength corresponding to the emission peak of fluorescence (phosphorescence) is comprised between 25 and 150 nm.

Abstract: A corrosion control system is disclosed including an anionic oxygen inhibitor, a cationic acid inhibitor or dispersant, and a noxious species inhibitor or scavenger for use in a fluid in contact with a metallic surface at low temperature, moderate temperature and especially at high temperature. A drilling fluid, a completion fluid, a production fluid and a geothermal fluid including an effective amount of the corrosion control system is also disclosed as well as methods for making and using same.

Abstract: Well fluids and methods are provided that can be used for stabilizing a shale formation, especially during drilling of a well into or through a shale formation. The well fluids include: (i) a continuous water phase; (ii) a viscosity-increasing agent, wherein the viscosity-increasing agent comprises water-soluble hydrophilic polymer; (iii) a fluid loss control agent; and (iv) a cyclodextrin-based compound. The methods of drilling include the steps of: (A) introducing the well fluid into a zone of a subterranean formation; and (b) drilling the zone.

Abstract: The present invention relates to compositions comprising tunable polymeric surfactants and methods for enhanced oil recovery.

Abstract: A method and apparatus for combining multiple sources of intake water for use in hydraulic fracturing and other oil and gas drilling operations and treating the water with peracetic acid prior to discharging into one or more frac tanks or into a well. The apparatus includes a manifold assembly that combines water from multiple sources prior to entering a mixer where PAA is injected in a finely dispersed spray under pressure to thoroughly mix the PAA and intake water prior to be discharged into one or more frac tanks. By using a manifold assembly, the apparatus is easily transported to different job site-locations and permits the use of standard connection fittings to easily connect the apparatus to existing fracturing equipment. A method for injecting the PAA and testing and adjusting the level of PAA is also disclosed.

Abstract: The present invention relates to a coating for sliding parts that allows using diamond like carbon (DLC) or DLC-comprising coatings in combination with Molybdenum- and/or Zinc-comprising lubricants in such a manner that enhanced reduction of wear and friction in comparison to the state of the art is attained. The coating system according to the present invention comprises at least a metal-comprising carbon layer of the type Me-C/a)-C:X, whose element composition can be expressed as (MeaC1-a)1-bXb with 0.3?a?0.6 and 0<b?0.3, where Me is a metal or a combination of different metals and X is an element different from Me and different from C or X is a mixture of elements different from Me and which doesn't contain C. Me can be preferably Chromium (Cr) or Molybdenum (Mo) and X can be preferably hydrogen (H) or a mixture of silicon and hydrogen (Si+H).

Abstract: The present application concerns an aqueous metalworking composition comprising in a concentrate or after dilution of a concentrate with water in a diluent: 0.002 to 40% by weight of component (a) which is a lubricity agent comprising at least one water-insoluble compound (a) having at least one hydrophobic aliphatic chain and at least one polar group and having a water solubility at 20° C. of less than 0.1 g/liter; 0.002 to 40% by weight of component (b) comprising at least one water-soluble corrosion inhibiting compound (b) having a water-solubility at 20° C. of more than 0.1 g/liter; 0.002 to 45% by weight of at least one emulsifying and dispersing agent (c) which contains at least one emulsifying and/or dispersing compound (c) which is water-soluble, water-miscible or water-dispersable and which is selected from the group consisting of non-ionic, anionic and zwitterionic surfactants; 0.

Abstract: The invention provides a lubricating grease composition containing the following components (a) and (b): (a) an ionic liquid having as an anion bis(trifluoromethylsulfonyl)imide; and (b) as a thickener a diurea compound of formula (1): R1NH-CO-NH-R2-NH-CO-NH-R3 (1) wherein R2 is an aromatic hydrocarbon group having 6 to 15 carbon atoms; and R1 and R3, which may be the same or different are each an aromatic hydrocarbon group having 6 to 12 carbon atoms, an alicyclic hydrocarbon group having 6 to 12 carbon atoms or a straight-chain alkyl group having 8 to 20 carbon atoms, with the groups represented by R1 and R3 containing the aromatic hydrocarbon group in an amount of 50 to 100 mol %. The lubricating grease composition of the invention can favorably be used under ultra-high vacuum, and under high temperatures of 200 to 300° C.

Abstract: Two-stroke cross-head marine compression-ignited engine system lubrication is effected by a composition comprising a major amount of an oil of lubricating viscosity containing at least 50 mass % of a basestock containing greater than or equal to 90% saturates and less than or equal to 0.03% sulphur or a mixture thereof, and respective minor amounts of an oil-soluble overbased metal alkyl salicylate detergent and an oil-soluble polyalkenyl-substituted carboxylic acid anhydride or an oil-soluble alkylated phenol. The presence of the anhydride or the phenol improves asphaltene dispersency in the lubricant.

Abstract: The present invention is able to provide a lubricating oil composition having excellent thermal/chemical stability even when used for a compression refrigerating machine using a saturated fluorinated hydrocarbon refrigerant having a low carbon number and a low global warming potential, by using a refrigerant containing a saturated fluorinated hydrocarbon having from 1 to 3 carbon atoms, which uses, as a base oil, an oxygen-containing organic compound composed of at least one member selected from a polyoxyalkylene glycol, a polyvinyl ether, a copolymer of a poly(oxy)alkylene glycol and a polyvinyl ether, a copolymer of a poly(oxy)alkylene glycol monoether and a polyvinyl ether, and a polyol ester, each having a water content of not more than 500 ppm by mass.

Abstract: Use of a lubricating oil composition comprising at least one Fischer-Tropsch derived base oil for reducing exhaust port blocking of a 2-stroke engine. The present invention also relates to a 2-stroke lubricating engine oil composition comprising (i) at least one Fischer-Tropsch derived base oil having a kinematic viscosity at 100° C. in the range of from 2 to 30 mm2/s at 100° C. and (ii) 5 wt % or greater of a hydrocarbon solvent; wherein the lubricating engine oil composition has a Blocking Index of greater than 130 as measured by the JASO M343-92 Exhaust System Blocking Test Method.

Abstract: A wet wiper for cleaning accumulated oral debris from removable dental appliances. The wet wiper comprises a water insoluble substrate and a physiologically acceptable cleansing composition. Methods for cleaning removable dental appliances are provided.

Abstract: The present invention relates to a composition comprising: (i) at least 20% by weight, relative to the total weight of the composition, of at least one C2-C4 monoalcohol; (ii) at least one polycondensate of ethylene oxide and of propylene oxide; and (iii) at least one nonionic surfactant other than the polycondensates (ii). The invention also relates to the use of this composition for cleansing the hair, and to a process for cleansing the hair using this composition.

Abstract: The present invention relates to provide a scrub soap and a method for manufacturing the same. A method for manufacturing a scrub soap includes preparing a scrub agent consisting of a shirasu and a hollow shirasu having a different average particle diameter each other, preparing a fatty acid composition consisting of at least one kind of fatty acid, preparing an alkali aqueous solution by dissolving at least one kind of alkali metal hydroxide of which molar ratio to at least one kind of fatty acid is not more than 1, and preparing a soap basis material by mixing the scrub agent, the alkali aqueous solution and the fatty acid composition.

Abstract: Cleaning solutions and processes for cleaning semiconductor devices or semiconductor tooling during manufacture thereof generally include contacting the semiconductor devices or semiconductor tooling with an acidic aqueous cleaning solution free of a fluorine containing compound, the acidic aqueous cleaning solution including at least one antioxidant and at least one non-oxidizing acid.

Abstract: Compositions for chemically removing sulfur deposits from reservoir formations, production tubing, flow lines, and other production equipment due to the production of sour gas and/or oil including reaction products of diamines and aldehydes at a mole ratio between about 1:1 and about 1:6, and methods for making and using same.

Abstract: Cosmetic cleaning agents include, in a suitable carrier, a) at least one alkyl sulfate salt and/or alkyl polyglycol ether sulfate salt, b) at least one amphoteric and/or zwitterionic surfactant according to one of the general formulae (I) or (II) as defined herein, c) at least one sorbitan acid ester and d) at least one non-ionic cellulose ether, with the proviso that the weight ratio of the alkyl sulfate salt(s) and/or alkyl polyglycol ether sulfate salt(s) a) to the amphoteric or zwitterionic surfactant(s) of formula (I) or (II) is in the range from 1:0.65 to 1:1.5.

Abstract: The present invention includes a cleaning composition that includes at least one alkalinity source, at least one surfactant, water and at least one polyglycerol graft polymer. The polyglycerol graft polymer includes a polyglycerol and a residue of at least one carboxylic acid or carboxylate containing compound in an amount less than or equal to about 40% by weight of the polyglycerol graft polymer.

Abstract: Inventive subject matter disclosed herein includes a perfume that includes water; alcohol; oil in a concentration of about 2 to 20% by weight; a scent imparting constituent; and a stabilizing agent in a concentration effective for imparting a capacity to make a misting spray pattern when the perfume is sprayed through a sprayer.