Abstract: The present invention provides novel organic compounds of Formula (I): methods of use, and pharmaceutical compositions thereof.

Abstract: The present invention provides oxadiazole pyridine derivatives of Formula (I), their use as medicaments and their use for treating multiple sclerosis and other diseases.

Abstract: The present invention relates to novel anthranilic diamide derivatives of the general formula (I) in which R1, R2, R3, R4, R5, R6, A, Q and n have the meanings given in the description, to their use as insecticides and acaricides for controlling animal pests, also in combination with other agents for activity boosting, and a plurality of processes for their preparation.

Abstract: The present invention relates to N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amine derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to formula (I) Wherein R1, R2, R3, R4, R5, R6 have the meaning defined in the claims. The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

Abstract: The present invention provides a formulation comprising a pesticide and/or a plant growth regulator; an acyl morpholine of the formula (I) where R is H, CH3 or C2H5; and a polar aprotic co-solvent different from an acyl morpholine of formula (I). The formulation can be used in treatment of plants, and is especially well suited for use as a soluble liquid formulation.

Abstract: The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.

Abstract: The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula (I). Where Cy1 is pyridinonyl, pyridinyl, quinolinyl or 9-ethyl-9H-beta-carbolinyl, each of which optionally substituted and where Cy2 is phenyl naphthyl.

Abstract: The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.

Abstract: This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.

Abstract: Block copolymer pharmaceutical compositions containing 3,3?-diindolylmethane (DIM). The pharmaceutical composition for peroral administration comprises 3,3?-diindolylmethane as an active component and a target additive, the target additive being a block copolymer of oxyethylene and oxypropylene, in which the content of the hydrophobic oxypropylene block is less than 50 mass % and the molecular mass of the hydrophilic oxyethylene block is equal to 2,250 Da or more, at a ratio of the active component to the selected block copolymer varying between 1:2 and 1:10. The composition improves absorption of the active compound by the bloodstream upon peroral delivery.

Abstract: The invention provides a crystalline hydrochloride salt of (S)-3-[(S)-1-(4-chlorophenoxy)-2-methylpropyl]pyrrolidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.

Abstract: The present invention relates to a stable pharmaceutical composition for injection containing docetaxel and a method of preparing the same. More particularly, the present invention relates to a pharmaceutical composition for injection containing docetaxel having better storage stability than conventional medications, which is prepared by dissolving docetaxel, a water-insoluble compound, in distilled water after mixing it with cyclodextrin (CD) and a water-soluble polymer such as hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP) and lyophilizing the mixture, and a method of preparing the same.

Abstract: An avermectin-based topical formulation is disclosed which is useful for prevention and treatment of head lice (Pediculus humanus capitis). This topical formulation may be formulated as a shampoo-condition which comprises an effective amount of avermectin, solubilizers, suspending agents, preservatives, non-ionic surfactants, humectants, a silicone compound, and water. Also disclosed are methods of using the topical formulations disclosed within this specification to treat either a susceptible or treatment-resistant strain of lice, as well as uses in the manufacture of a medicament for treating or preventing a lice infestation from a susceptible or treatment-resistant strain in a human patient.

Abstract: The present invention is an ophthalmic composition containing a relatively high concentration of olopatadine. The composition is typically an ophthalmic aqueous solution containing relatively high concentrations of olopatadine solubilized within the solution. The composition is preferably capable of providing enhanced relief from symptoms of ocular allergic conjunctivitis, particularly late phase symptoms of ocular allergic conjunctivitis.

Abstract: The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondria) disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

Abstract: A polyacetylenes and application thereof. The polyacetylenes is isolated from an extract of the sporophores of Antrodia Cinnamomea and has a function of inhibiting the production of nitric oxide. Therefore, the polyacetylenes can be used for preparing a pharmaceutical composition for anti-inflammation. The present invention also teaches the representative metabolites of the sporophores of Antrodia Cinnamomea, which can be used to evaluate the quality thereof.

Abstract: Methods of inhibiting cytochrome P450 2D6 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450 2D6. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 2D6 enzymes.

Abstract: The present invention includes methods for treating Meibomian gland dysfunctions. The invention also includes methods for improving tear lipid composition, for treating abnormal Meibomian gland secretion and for normalizing Meibomian gland secretions.

Abstract: A compound having an ability to bind to an SIP receptor and represented by formula (I), a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like: wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.

Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.

Abstract: The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

Abstract: This invention relates to deuterated compounds which are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: Novel melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR8; Y is selected from the group consisting of hydrogen, aryl, heteroaryl, C1-C6 alkyl, C3-C6 cycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, —OCF3, CF3, C1-C8 alkyl, C1-C8 alkyloxy, C1-C8 alkylthio, halogen and —Z—(CH2)p-A; R1 is selected from the group consisting of C1-C4 alkyl, C3-C6 cycloalkyl, CF3, hydroxy-substituted C1-C4 alkyl, hydroxy-substituted C3-C8 cycloalkyl, and NHR5, wherein R5 is C1-C3 alkyl or C3-C6 cycloalkyl; R2 is selected from the group consisting of: hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R3 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R and R3 may be connected together to form an —O—(CH2)v bridge representing with the carbon atoms to which th

Abstract: The present invention relates to a monolithic solid catalyst for carrying out a heterogeneous catalytic chemical reaction in a reaction fluid which flows through the catalyst and comprises at least one educt, wherein the catalyst has at least one passage opening for the reaction fluid to flow through the catalyst. In order to obtain a larger and targeted yield and selectivity of the sought reaction products with a smaller design of the reactors, smaller energy feed and smaller reaction pressures and/or lower reaction temperatures, it is proposed according to the invention that, to increase the effectiveness of the chemical reaction, the catalyst has at least one mechanical oscillator by which, while carrying out the chemical reaction, the catalyst can be subjected to a mechanical frequency in the range of from 20 kHz to 2 GHz.

Abstract: This invention discloses a method for making a dimethylether (DME) product from a synthesis gas (syngas) in the presence of a catalyst in a fluid pluralized bed reactor operating in the gas phase. The reactions generate a significant amount of heat and the heat management is balanced between supplying quench recycle syngas to the pluralized sections along the reactor and also by controlling the preheat temperature of the reactant streams. Gas phase fluidization of the catalyst is controlled so that the pluralized reactive zones are maintained in a backmix configuration.

Abstract: The invention provides a method for producing methanol and its products exclusively from a geothermal source as the sole source material also using the needed energy from the geothermal energy source. The method includes separating or isolating carbon dioxide accompanying hot water or steam of the source, generating hydrogen from the water and subsequently preparing methanol from the carbon dioxide and hydrogen. The methanol can be further converted into dimethyl ether or other products.

Abstract: A composition including an effective amount of trans-1,3,3,3-tetrafluoropropene component combined with an effective amount of an alcohol selected from the group of methanol, ethanol, propanol, isopropanol, tert-butanol, isobutanol, 2-ethyl hexanol and any combination thereof, where the composition has azeotropic properties.

Abstract: A viscoelastic polyurethane foam is the reaction product of at least one natural oil derived polyol and at least one aromatic compound having an average of more than one isocyanate group. A viscoelastic polyurethane foam has an air flow of at least about 0.5 l/s, wherein the foam is formed in the substantial absence of copolymer polyol and has not (yet) been mechanically reticulated and is preferably prepared using at least one natural oil derived polyol, more preferably in an amount of at least about 20 weight percent of the polyols used. A process of preparing a viscoelastic foam, comprises steps of (A) forming a reaction mixture including at least one polyol, at least one polyisocyanate, water, at least one catalyst wherein a the polyol comprises at least one natural oil derived polyol; and (B) subjecting the reaction mixture to conditions sufficient to result in the reaction mixture to expand and cure to form a viscoelastic polyurethane foam.

Abstract: The present invention relates to a fluorene-based resin polymer, and a photosensitive resin composition including the same, and the fluorene-based resin polymer according to the exemplary embodiment of the present invention has a high molecular weight, a low acid value, and excellent developing property, adhesive property and stability.

Abstract: Disclosed is a photocurable organopolysiloxane composition including (A) 100 parts by weight of diorganopolysiloxane having at least two silicon atoms having a hydroxyl group and/or hydrolyzable group attached thereto in one molecule; and (B) 0.1 to 30 parts by weight of a complex compound composed of titanium(meth)acrylate-trialkoxide and ?-diketone. It will find use as a sealing agent, adhesive, coating material. It is particularly suitable for micro pars and precision molding on account of its good curability and very little cure shrinkage.

Abstract: Biodegradable coatings for implantable medical devices are disclosed.

Abstract: A paste is provided from which bone cement can be formed, which is to the largest extent possible bubble-free and has a high impact strength. The paste includes (i) 15-50 weight percent of at least one mono-functional, hydrophobic methacrylic acid ester, (ii) 40-85 weight percent of at least one filler, (iii) 0.01-4 weight percent of at least one radical initiator soluble in the methacrylic acid ester (i) and having at least one peroxide group, (iv) 0.01-4 weight percent of at least one radical initiator soluble in the methacrylic acid ester (i) and having no peroxide groups, (v) 0.000001-3 weight percent of at least one accelerator soluble in the methacrylic acid ester (i) and capable of forming radicals from the radical initiators according to (iii) and (iv), (vi) 0.001-5 weight percent of at least one halide salt, and (vii) 0.2-3 weight percent of at least one cross-linking agent.

Abstract: An insulating ink composition for forming an insulating film, which sufficiently achieves a low calcination temperature, solvent resistance and an insulating property, is provided. Furthermore, an ink composition for forming an insulating film which can form, by the printing method, fine insulating film patterns necessary for formation of highly integrated organic transistors is provided. The present invention provides an ink composition which forms an insulating film, and includes an organic solvent, a polyvinylphenol-based resin, an epoxy resin and a cross-linking aid. Particularly, the ink composition is a composition wherein the organic solvent includes an organic solvent which has a vapor pressure of 11.3×102 Pa or higher at 20° C. and a boiling point of lower than 115° C. under atmospheric pressure and an organic solvent which has a vapor pressure of less than 11.3×102 Pa at 20° C. and a boiling point of 115° C.

Abstract: An ink composition includes a particulate pigment, a hydrocarbon vehicle, an organic polyamine and an organic polyacid. A ratio by weight percent of the organic polyamine to the organic polyacid in the hydrocarbon vehicle is sufficient to render a conductivity of the ink composition to equal to or less than 15 nanosiemens per centimeter. The ink composition is prepared by combining the particulate pigment with a composition that includes the hydrocarbon vehicle, the organic polyamine and the organic polyacid. The combination is subjected to conditions under which the particulate pigment becomes dispersed in the composition.

Abstract: Disclosed is a liquid coagulant which can be injected into the inside of a tire without removing the tire from a rim and which can prevent the scattering of a residue of a tire puncture sealing material when the tire is removed from the rim. The liquid coagulant can coagulate an emulsion that contains a natural rubber latex. The liquid coagulant comprises a urethane resin and/or an acrylic resin which has a pH value of 2.0 to 4.0 and contains a cationic functional group.

Abstract: The invention is directed to a process and apparatus for carrying out reactions with reaction mixtures comprising different physical phases. In a first aspect, the present invention is directed to a process for carrying out chemical reactions comprising a step wherein a reaction mixture comprising at least two different physical phases, wherein at least one of these phases being liquid, is subjected to the action of Dean vortices, which Dean vortices result from said liquid flowing through a channel having at least two curvatures, wherein the channel comprises for at least a fraction of its total length a smooth inner surface.

Abstract: An elastomer composite with silica-containing filler is described, along with methods to make the same. The advantages achieved with the elastomer composite and methods are further described.

Abstract: A fiber-cement product which includes a treated cellulose wood pulp fiber. The fiber is treated with fibrillated carboxymethyl cellulose or a carboxyethyl cellulose and poly(diallyldimethylammonium chloride). The fiber can be bleached or partially bleached, refined or unrefined or a mixture of refined and unrefined fiber.

Abstract: Thermoplastic molding compositions comprising A) from 29 to 99.7% by weight of a thermoplastic polyester, B) from 0.3 to 3% by weight (based on 100% by weight of A)+B)) of an imide salt of the formula or a mixture of these, where Me is intended to be an alkali metal, C) from 0 to 70% by weight of further additives, where the total of the percentages by weight of A) to C) is 100%.

Abstract: Polyamide-reinforced polyacrylate polymer compositions comprising a continuous polyacrylate polymer phase and a discontinuous polyamide phase are produced by a melt mixing process. When crosslinked with peroxide curatives the polyamide-reinforced polyacrylate polymer compositions exhibit enhanced resistance to heat aging compared to carbon black-reinforced polyacrylate polymer compositions.

Abstract: A reinforced poly(phenylene ether)-polysiloxane block copolymer composition includes specific amounts of a poly(phenylene ether)-polysiloxane block copolymer reaction product, a flame retardant, and a reinforcing filler. The composition exhibits a desirable balance of flame retardancy, heat resistance, and stiffness relative to a corresponding poly(phenylene ether) composition, and it is useful to fabricate articles including fuser holders for electrophotographic copiers.

Abstract: The object of the present invention is to provide a solar cell sealing film obtained from a composition comprising chiefly ethylene-vinyl acetate copolymer and organic peroxides for giving crosslinked structure, which suppresses the occurrence of blisters without reduction of crosslink rate, even if the film contains silane-coupling agents for improving adhesive strength. The solar cell sealing film comprises ethylene-vinyl acetate copolymer, an organic peroxide, a silane-coupling agent, and a phosphite compound represented by formula (I): P(OR1)3??(I) wherein, R1 is a branched-chain aliphatic alkyl group having 8 to 14 carbon atoms, and three R1s are the same as or different from each other and further wherein the content of the vinyl acetate recurring unit of the ethylene-vinyl acetate copolymer is in the range of 20 to 35% by weight.

Abstract: Disclosed is a method for defoaming a vinyl chloride resin slurry. The agent of the present invention may prevent generation of Fish eyes and deteriorate in production efficiency caused by slurry foams without inhibiting inherent transparency of vinyl chloride resins, in the process of preparing the vinyl chloride resins by polymerizing a monomer mixture containing vinyl chloride as a main component in a polymerization reactor.

Abstract: A two-component polyurethane adhesive is provided, which comprises a component A comprising at least one polyol with a molecular weight of more than 500 g/mol, a component B comprising at least one polyisocyanate with a molecular weight of less than 1000 g/mol, and additional additives. The component A contains 0.1 to 10 wt. % sterically hindered amines having primary amino groups.

Abstract: The invention provides an adhesive or sealant comprising (A) at least one compound selected from the group consisting of polyurethanes, polyureas, polyacrylates, polysulphides, silylated polyurethanes, silylated polyureas, silylated polyethers, silylated polysulphides and silyl-terminated acrylates, and (B) at least 0.32% by weight of 2-ethylhexyl methyl terephthalate, based on the overall adhesive or sealant. A process is disclosed for preparing the adhesive or sealant, and also disclosed is the use thereof for producing material bonds between parts to be joined.

Abstract: A method of determining that a thermoplastic was insufficiently dried before forming into a molded plastic part. The method comprises preparing a mixture of a thermoplastic polymer and an off-gassing compound, wherein the off-gassing compound is selected to release all water of hydration in response to target drying conditions specified for the thermoplastic polymer. The mixture is dried at actual drying conditions, and then heated to reduce the viscosity of the thermoplastic polymer and allow the mixture to flow. The mixture is then made to flow into a mold to form a plastic part at a molding temperature, wherein the molding temperature will cause any remaining water of hydration in the off-gas sing compound to off-gas and form surface irregularities in the plastic part. Non-limiting examples of the off-gassing compound include hydrated metal halides and ionic hydrates.

Abstract: A polyester composition containing: a) aluminum atoms; and b) alkaline earth atoms or alkali metal atoms or alkali compound residues such as lithium atoms; and c) particles comprising titanium, zirconium, vanadium, niobium, hafnium, tantalum, chromium, tungsten, molybdenum, iron, or nickel atoms or combinations thereof, where the particles improve the reheat rate of the polyester composition. The polyester polymer compositions may also contain phosphorus catalyst deactivators/stabilizers. The polyester compositions and the articles made from the compositions such as bottle preforms and stretch blow molded bottles have improved reheat rate while maintaining low haze, high L*, a b* below 3, and have low levels of acetaldehyde. In the process for making the polyester polymer, the polymer melt is polycondensed in the presence of a) and b), with the particles c) added in a melt phase process or added to the polymer in an injection molding machine or extruder.

Abstract: The present disclosure relates a polymer composite comprising a polystyrene or a polystyrene derivative comprising styrene or styrene derivative monomer units in which at least about 1% (mole fraction) of a phosphonium ion salt ionic liquid is incorporated into the structure of the polystyrene or polystyrene derivative, and processes for the production thereof.

Abstract: A thermoplastic composition comprises, based on the total weight of the composition: 51-90 wt % polyester, 10-49 wt % ABS impact modifier; 0-20 wt % of multifunctional epoxy compound; 0-40 wt % filler; 0-2 wt % fibrillated fluoropolymer; and more than 0 to 5 wt % of a stabilizer composition. An article blow molded or injection molded from the composition has a multi-axial impact total energy from 30-100 Joules at ?30° C. and a ductility of more than 90%; a permeability of more than 0 and less than or equal to 1.5 g/m2-day to ASTM D 471-98 Fuel C, measured after exposure to ASTM D 471-98 Fuel C vapor for 20 weeks at 40° C.; an MVR of 1-20 cc/10 min., measured at 265° C.; a flexural modulus of greater than 1300 MPa; and retains at least 75% of its initial tensile elongation at break, after exposure to Fuel E85 for 28 days at 70° C.

Abstract: The present invention provides one component aqueous compositions comprising (i) a cationic stain blocking polymer chosen from (a) 0.01 to 7 wt. % of anion exchange resin copolymer gelular or dual morphology beads that have a weight average particle size of from 0.1 to 20 ?m and a low copolymerized crosslinker content of from 0.5 to 2.0 wt. %, (b) from 1 to 30 wt. % a crosslinked cationic addition polymer and (c) mixtures thereof, (ii) one or more emulsion copolymer having a copolymerized residue of at least one phosphorus acid monomer, and (iii) a stabilizer of from 0.1 to 2 wt. % of an inorganic phosphorus containing dispersant, and from 0.2 to 5.0 wt. % of a mixture of a nonionic surfactant and an anionic surfactant, both wt. % s based on the total weight of emulsion copolymer solids. The compositions provide stabilized binders for in a single coat primer plus topcoat coatings and paints.