Abstract: A combustion system is provided for an oxy-combustion furnace. The combustion system includes at least one windbox mountable on the oxy-combustion furnace and having at least one main firing location. At least one primary inlet is positioned in the at least one main firing location for conveying fuel and the first oxidant into the oxy-combustion furnace. At least one secondary inlet is positioned in the at least one main firing location for conveying the second oxidant into the oxy-combustion furnace. The at least one secondary inlet is angularly offset from the at least one primary inlet.

Abstract: The invention relates to a measuring apparatus comprising a coating probe and a probe holder which is disposed on a wall of a sample chamber. The coating probe is displaceable into the sample chamber on one side and is displaceable out from the sample chamber on the opposite side. As a result, practical investigations of boiler coatings are made possible.

Abstract: Orthodontic appliances and related methods are provided, including a fast-dissolving and humidity-resistant coating, containing a colorant and a binder selected from a polyamide, cellulose derivative, or homopolymer/copolymer of poly(ethylene oxide). The coating can facilitate appliance identification and serve as a reference marking to assist the practitioner in appliance placement. Advantageously, the composition of these coatings allows the color marking to be rinsed off quickly, and yet the color of the coating does not bleed during storage even in high humidity environments. The fast-dissolving nature of these coatings also allows the coating to be deposited in concave and recessed areas of the appliance, such as the archwire slot and vertical slot, since these coatings can be removed prior to archwire installation.

Abstract: The present invention employs a self-ligating orthodontic bracket comprising a body having a pair of laterally spaced gingival tie wings and a pair of laterally spaced occlusal tie wings, the gingival and occlusal tie wings projecting from a labial surface of the body; an arch wire slot extending mesially-distally across the body and between the gingival and occlusal tie wings to accommodate an arch wire; a free-sliding, controlled-locking, or pivoting clip wherein the clip allows placement and removal of the arch wire when in the open position and prevents the displacement of the arch wire from the bracket member when in the closed position.

Abstract: A heating apparatus (10) for heating materials used in dental treatment is provided. The heating apparatus (10) comprises a heating compartment (33) with a heating element (35) for heating air inside the heating compartment (33), at least one socket for receiving and holding at least a part of the materials used in dental treatment inside the heating compartment (33), and an airflow generator (32, 34) for generating an airflow in the heating compartment (33).

Abstract: A light for use with an oral anesthesia syringe that is received into a passageway of a barrel of the light. When the syringe is received into a first opening in a proximal end of the barrel's passageway, the needle of the syringe extends through a second opening at the proximal end of the barrel. At least one lamp and preferably a plurality of lamps at the distal end of the barrel illuminate the needle and the interior of a patient's mouth. A battery is included in the light for powering the lamps. The insertion of the syringe into the barrel closes a pair of contacts to cause the battery to power the lamps, or the battery may be removed to remove power from the lamps.

Abstract: A medical or dental treatment device for use in an oral or dental procedure, comprises a base part with a power supply unit and an electrical or electronic control device and a set of different parts for use with the base part. The set of different parts comprises at least one delivery part for a first treatment phase and comprising a sound or ultrasound source, a movable piston and a piston operating element operable to deliver a substance from the delivery part to a treatment site, and at least one active part for use in a second treatment phase to act on the treatment site. The active part comprises a sound source, an ultrasound source and/or an electromagnetic radiation source. The delivery part and the active part are selectively connectible to the base part for use in consecutive treatment phases (the first can precede or follow the second).

Abstract: A method for detecting a movable object in a location includes —providing a first 3D representation of at least part of a surface by scanning; —providing a second 3D representation of at least part of the surface by scanning; —determining for the first 3D representation a first excluded volume; —determining for the second 3D representation a second excluded volume; —if a portion of the surface in the first 3D representation is located in space in the second excluded volume, the portion of the surface in the first 3D representation is disregarded, and/or —if a portion of the surface in the second 3D representation is located in space in the first excluded volume, the portion of the surface in the second 3D representation is disregarded

Abstract: A coupling device for detachably connecting a medical or dental instrument to a drive unit or a supply hose for transfer of at least one of data, energy, a driving movement and a working medium between the drive unit or the supply hose and the instrument comprises a first coupling element and a second coupling element. One of the coupling elements comprises a coupling recess and the other comprises a coupling protrusion insertible therein. One of the coupling elements comprises a positioning element and the other comprises an indentation into which the positioning element can be inserted to position the coupling elements in a defined angular position about a shared axis. One of the coupling elements comprises a memory unit for storage of data and the other comprises a transfer unit, so that data can be transferred from the memory unit by the transfer unit to the other coupling element.

Abstract: A cleaning instrument for an endodontic procedure such as a root canal provides a distal portion for agitating an irrigant, comprising in some embodiments agitating structures that stir the irrigant to assist in removing the smear layer and dislodging loosely adhered organic debris. The structures may also be designed to assist in evacuating irrigant from the canal. Some embodiments provide orifices through which an irrigating fluid can traverse the distal portion of the instrument and enter the canal to wash away loosened debris and sterilize the canal.

Abstract: An In-situ Tooth Filling System and Method Utilizing External Curing Step. The method and system utilizes the heat-/light-/vacuum-curing process normally available only in a dental laboratory. Like the conventional dental prosthetic production process, the filling is attached to the tooth void utilizing curable cement. Unlike the conventional (indirect) method, however, the instant method is completed totally within a single appointment in the dentist's office. The system utilizes fill stems that are made from curable filling material. These stems will become a part of the filling when the filling is cured. The filling is partially cured and then removed from the tooth for final curing in a vacuum oven that heat- and/or light-cures the filling.

Abstract: A composite capsule for receiving and dispensing a dental compound. The composite capsule has a receiving space, which is surrounded by a capsule wall and which extends between a discharge opening and a receiving opening, wherein the discharge opening is arranged at a front end of the receiving space, and the receiving opening is arranged at a rear end of the receiving space. The composite capsule comprises a support face, which protrudes outward in relation to the capsule wall and which is oriented in the direction of the front end. The support face is interrupted by a thread recess. By way of the thread recess, the composite capsule can be connected to a storage container, in order to introduce a desired amount of dental compound into the composite capsule.

Abstract: A dental mouthpiece is provided that may be attached to a high-suction dental adapter for the purpose of assisting the dental staff during dental procedures through chair-side, hands-free suction, and isolation. Such a mouthpiece may comprise a main body portion, a cheek retractor portion, and a suction connector portion. In some embodiments, the main body portion, cheek retractor portion, and suction connector portion (and sub-portions thereof) may be molded in one piece, preferably by injection molding. In an exemplary embodiment, the mouthpiece may be made of a material that is flexible, translucent, conducive to injection molding, high heat-resistant, and autoclavable. Such a material may include silicone. Because the mouthpiece may be made of a high heat-resistant and autoclavable material, such a mouthpiece may be reusable.

Abstract: A dental mouthpiece is provided that may be attached to a high-suction dental adapter for the purpose of assisting the dental staff during dental procedures through chair-side, hands-free suction, and isolation. Such a mouthpiece may comprise a main body portion, a cheek retractor portion, and a suction connector portion. In some embodiments, the main body portion, cheek retractor portion, and suction connector portion (and sub-portions thereof) may be molded in one piece, preferably by injection molding. In an exemplary embodiment, the mouthpiece may be made of a material that is flexible, translucent, conducive to injection molding, high heat-resistant, and autoclavable. Such a material may include silicone. Because the mouthpiece may be made of a high heat-resistant and autoclavable material, such a mouthpiece may be reusable.

Abstract: A dental mouthpiece is provided that may be attached to a high-suction dental adapter for the purpose of assisting the dental staff during dental procedures through chair-side, hands-free suction, and isolation. Such a mouthpiece may comprise a main body portion, a cheek retractor portion, and a suction connector portion. In some embodiments, the main body portion, cheek retractor portion, and suction connector portion (and sub-portions thereof) may be molded in one piece, preferably by injection molding. In an exemplary embodiment, the mouthpiece may be made of a material that is flexible, translucent, conducive to injection molding, high heat-resistant, and autoclavable. Such a material may include silicone. Because the mouthpiece may be made of a high heat-resistant and autoclavable material, such a mouthpiece may be reusable.

Abstract: A dental mouthpiece is provided that may be attached to a high-suction dental adapter for the purpose of assisting the dental staff during dental procedures through chair-side, hands-free suction, and isolation. Such a mouthpiece may comprise a main body portion, a cheek retractor portion, and a suction connector portion. In some embodiments, the main body portion, cheek retractor portion, and suction connector portion (and sub-portions thereof) may be molded in one piece, preferably by injection molding. In an exemplary embodiment, the mouthpiece may be made of a material that is flexible, translucent, conducive to injection molding, high heat-resistant, and autoclavable. Such a material may include silicone. Because the mouthpiece may be made of a high heat-resistant and autoclavable material, such a mouthpiece may be reusable.

Abstract: A dental mouthpiece is provided that may be attached to a high-suction dental adapter for the purpose of assisting the dental staff during dental procedures through chair-side, hands-free suction, and isolation. Such a mouthpiece may comprise a main body portion, a cheek retractor portion, and a suction connector portion. In some embodiments, the main body portion, cheek retractor portion, and suction connector portion (and sub-portions thereof) may be molded in one piece, preferably by injection molding. In an exemplary embodiment, the mouthpiece may be made of a material that is flexible, translucent, conducive to injection molding, high heat-resistant, and autoclavable. Such a material may include silicone. Because the mouthpiece may be made of a high heat-resistant and autoclavable material, such a mouthpiece may be reusable.

Abstract: The invention relates to a dental prosthesis, comprising an implant body (1) and an abutment (2) that can be inserted into a receptacle of the implant body (2), said abutment forming a passage opening (5) for accommodating a head screw (4) that engages in a female thread (6) of the implant body (1) and supports a tooth structure (3) secured against twisting. In order to ensure simple constructional conditions it is proposed that the head (7) of the head screw (4) is connected in an interlocking manner to an anti-rotation device (9) which can only be twisted together with the head screw (4) and which is glued together with the tooth structure (3).

Abstract: The present invention relates to dental implants, and more particularly to custom dental implant fixture that shortens the extraction to completed restoration period from 6-8 months to 4 months. The invention is to use the existing extraction site as is to place custom implant fixture, thereby avoiding a lengthy extraction healing stage and the subsequent osteotomy surgery.

Abstract: A dental-implant system (1) having a first implant part (2) provided for being inserted into a jawbone and having a second implant part (4) associated therewith, provided for fixing a dental prosthetic piece, the implant parts (2, 4) being mechanically connectable to each other via a connection pin (8) which is formed onto one of the implant parts (4) and which can be pushed into a receiving channel (10) provided in the other implant part (2), and the cross-section of the connection pin (8) and the cross-section of the receiving channel (10) associated therewith each presenting in an indexing area a number of main directions (20) in which the radius takes in each case a relative maximum value, shall offer an even increased mechanic load-carrying ability and thus a particularly long service life when used in the patient's mouth.

Abstract: The current disclosure is directed to a dental implant system and method that modifies the screw access channel of an implant-supported abutment in order to improve cement retention within the abutment chamber and to improve retention strength of prosthesis. The cement-retaining system comprises an abutment screw and a longitudinal extension of the abutment screw that channels excess cement into the chamber. The extension may be made from a variety of materials, including metal alloys, plastic materials, or materials that have a low melting point and can be removed in order to allow easy access to the screw head. In one implementation, the extension is affixed at the head of an abutment screw. In other implementations, the extension and the abutment screw are a continuous unit. Experiments demonstrate that the extension increases the volume of cement within the abutment chamber and improves the retention ability of the abutment-restoration complex.

Abstract: An excavator (10) has a quick coupler (24) coupled to the distal end (22) of its excavator arm (12). The quick coupler (24) can be operated from the cab (14) of the excavator (10), and is connected to a warning control system (48) or an instructional device (102). The warning control system (48) is connected to a coupler control circuit (46), which controls the coupler (24) and the system or circuit acquires information on the coupler's status. A control system activation warning circuit is then arranged to be responsible for issuing warning signals (53, 54) to personnel located external of the cab when the coupler control circuit (46) is activated into an accessory coupling procedure mode, or an accessory decoupling procedure mode. To do this, the warning circuit (48) is coupled to an audio and/or visual alarm (50, 52) for directing the warnings (53, 54) to the personnel, including bystanders. The instructional device, however, instructs the operator as to how to use the coupler.

Abstract: A method and apparatus for assessing performance in operating an aircraft. Information for assessing a performance of a group of operations performed by a number of crew members of the aircraft is displayed on a display system during operation of the aircraft by the number of crew members for which the group of operations is assessed. User input assessing the performance of the group of operations by the number of crew members is received through an input system. The user input is stored. A report on the performance of the group of operations performed by the number of crew members using the user input is generated.

Abstract: A system and method for minimizing or eliminating Coriolis-tumbling sensations on a trainee in a centrifuge-based simulator is described. In one example methodology, a simulator transitions its rate of rotation to replicate flight conditions in which G-forces are unloaded on a trainee from a first-G-force value to a nominal-G-force value. Before reaching the nominal-G-force value, an intermediate-G-force value—which is more than the nominal-G-force value, but less than the first-G-force value—is imparted and maintained on the trainee for a suitable duration of time. This intermediate-G-force value may be determined based on several factors including: (i) the angle of rotation of a gondola at during the first-G-force value, and/or (ii) the first-G-force value. After the intermediate-G-force value is imparted and maintained for a suitable duration of time, the G-forces imparted on the trainee may be further unloaded till the nominal-G force value is reached.

Abstract: A driving skill in input driving data is acquired from driving skill classification unit, driving data, which includes a driving skill higher than the driving skill in the input driving data and of which a similarity to the input driving data is at least a predetermined similarity, is selected from among driving data stored in a driving data storage unit, a difference between the selected driving data and the input driving data is detected, and a notice on the detected difference is issued as driving advice. As a result, it is possible to present suitable advice to improve a driving skill taking into account the skill and type of a driver.

Abstract: A body weight management device includes: a change obtainment unit for obtaining an intra-day body weight change value on a daily basis based body weight measurement values of a measurement subject measured on a daily basis; an achievement rate obtainment unit for comparing the intra-day body weight change value obtained by the change obtainment unit with an intra-day target weight loss value and obtaining, based on a result of the comparison, a target achievement rate indicating a percentage of total days in a predetermined period in which the intra-day body weight change value has reached the intra-day target weight loss value; and a target obtainment unit for obtaining, based on the target achievement rate obtained by the achievement rate obtainment unit, a new intra-day target weight loss value to serve as a target for future body weight measurement.

Abstract: My Binary Mixed Equation is a new math equation format and my Binary Quads Puzzles, Binary Quads Games and Binary-School Cads are new math related instructional aids I created to introduce students to the world of Base Two numbers, while reinforcing their math kills. I used Binary Coded Decimal number sequences of ones (1) and zeros (0) to represent decimal numbers within a traditional equation format. I then created my Binary Quads Puzzles and Games by combining my Binary Mixed Equations and traditional equations into mathematically functional equation based puzzle designs. I developed a process of individually pivoting a group of equations from their traditional horizontal orientation and then rotating each of them to different angles from 0 to 360 degree before arranging each equation within a crisscrossing, intersecting and bisecting design to create multiple puzzle designs that are functional, instructive and recreational.

Abstract: An apparatus and methods for training workers to recognize distortions. One example method includes positioning vacuum arms on a tilt-table top of a distortion training table situated in a horizontal position. The method further includes positioning locator arms on the tilt-table top in proximity to the vacuum arms, positioning a body panel on the locator arms to situate an inner surface of the body panel adjacent to each of the vacuum arms, applying suction to the inner surface of the body panel using the vacuum arms wherein the suction creates non-destructive distortions on an outer surface of the body panel, instructing the workers in tactile recognition of the distortions on the outer surface of the body panel, moving the tilt-table top from the horizontal position to a vertical position, and instructing the workers in visual recognition of the distortions on the outer surface of the body panel.

Abstract: A multi-modal interaction modeling system can model a number of different aspects of a human interaction across one or more temporal interaction sequences. Some versions of the system can generate assessments of the nature or quality of the interaction or portions thereof, which can be used to, among other things, provide assistance to one or more of the participants in the interaction.

Abstract: A multi-modal interaction modeling system can model a number of different aspects of a human interaction across one or more temporal interaction sequences. Some versions of the system can generate assessments of the nature or quality of the interaction or portions thereof, which can be used to, among other things, provide assistance to one or more of the participants in the interaction.

Abstract: The present disclosure relates to a fitness system which includes an input device; a display device; and a processor. The processor is configured to transmit a survey to a user, wherein the survey comprises a plurality of questions related to the physical or performance abilities of the user for a predetermined plurality of exercises; receive answers to the survey from the input device; determine a suggested exercise routine based on at least the answers to the survey; and transmit the suggested exercise routine to the user.

Abstract: A necklace that contains a gear assembly within a housing where gears of the gear assembly are rotated by a driving component. The driving component is a necklace chain where the chain, for example is a ball chain or a box chain that passes through openings in a housing wall and is configured to physically rotate gears.

Abstract: One or more systems and/or techniques are provided for generating a workout routine. For example, a first input including a first tool available to a user and/or a second input including a modality may be received. A set of movements may be generated based upon the first tool and/or the modality. A workout routine may be generated based upon the set of movements. The workout routine can be generated based upon a selection of one or more movements from the set of movements. In an example, the one or more movements are randomly selected from the set of movements. The results of the workout routine may also be tracked.

Abstract: The invention provides a training aide for swimmers and sportsperson. The device includes a tail piece which extends from a head support. The tail piece is aligned so that it will contact with the body, so as to provide feedback to the wearer when their head has moved and is not properly aligned. The tailpiece may be aligned so that raising the head causes the tailpiece to press against the back of the neck or shoulders. The head support may be integrated into the strap of swimming goggles, or have a separate head strap suited for holding the training device.

Abstract: An object designed to improve the hand-eye coordination of a user. The object comprising a plurality of distinct zones with each zone have a unique indicator. In use a user will verbally identify the indicator prior to catching the object. Preferably, the object is a spherical shaped ball.

Abstract: A virtual-reality method for surgical training simulates the task of detecting sentinel lymph nodes using a nuclear uptake probe. The simulator can be used with lymphoscintigraphic clinical imaging data to provide patient-specific training scenarios. In yet another embodiment, the apparatus can use a database representing mathematical phantoms to simulate different patient sizes, node distributions, node uptakes, and combinations thereof.

Abstract: An educational suturing apparatus is presented. The educational suturing apparatus may include a support layer and an imitation skin layer. The support layer may include an insert protruding from the support layer. An inner surface of the imitation skin layer may fit over the insert. The imitation skin layer may be made of an elastomer so that an incision may be cut and sutured back together.

Abstract: Devices, systems, and methods appropriate for use in medical training are provided. In some implementations, the devices, systems, and methods are not dependent on external power supplies or internal batteries. A patient simulator is provided that includes a simulated patient body portion; and an electric-harvesting system positioned within the simulated patient body portion. The electric-harvesting system converts mechanical energy applied to the simulated patient body portion into electric energy for use by one or more components of the simulated body portion.

Abstract: Simulated pregnant abdominal systems and associated devices, systems, and methods are provided. The pregnant abdominal systems allow an interactive scenario simulating a routine gestation palpation of a fetal baby, the performance of an external cephalic version as well as the Leopold's Maneuvers. Further, the pregnant abdominal systems can be used as a platform to physically hear the fetus heartbeat using stethoscope, Doppler Instrument, or a Pre-Natal Monitor. Further, in some implementations the fetus can be visualized using standard ultrasound systems.

Abstract: Systems and methods are disclosed for an apparatus and method for practicing injection techniques through an injectable apparatus. The injectable apparatus may contain a camera that is configured to provide three-dimensional location information for a testing tool based on light attenuated from the testing tool after it is injected into a simulated human or animal body parts. A training tool may be connected to a user display device to generate a display of the injection apparatus as well as the performance parameters of a trainee.

Abstract: A system for enabling real time live proctoring of an exam across a distributed network includes a first remote computer. The first remote computer is capable of real time audio visual capture and display of an image of a user of the first remote computer. A second remote computer is capable of real time audio visual capture and display of an image of the user of the second remote computer. A server is in communication with the first remote computer and the second remote computer, and provides an interactive web based scheduling portal accessible from the first remote computer and the second remote computer. A database is associated with the server for storing data regarding the rules for proctoring of an exam including the rate at which an exam may be proctored at a given date and time.

Abstract: A method of inducing a learner to log into a learning content-providing server, which is performed by a learner terminal, the method including: receiving an input of uniform resource locator (URL) information that is printed in a textbook; accessing a location in the learning content-providing server, which corresponds to the URL information; receiving and playing a learning content file, which is stored in the location in the learning content-providing server; and if a period or number of times the received learning content file is played expires, frequently accessing the learning content-providing server and requesting to extend the period or number of times the learning content file is played.

Abstract: The present disclosure is drawn to a device for monitoring and controlling live cells and associated methods. In an example, the device can include a plurality of elongated nanostructures affixed to a substrate. The elongated nanostructures can each have an attachment end and a free end opposite the attachment end. The free end includes a metal and the attachment end is affixed to the substrate. The device can further include a functionalization layer that is coated on the free end of at least a portion of the plurality of elongated nanostructures. The functionalization layer can be formulated to retain live cells, and the device can be configured to be used in conjunction with a detector, such as a Raman spectrometer, in order to monitor growth of live cells.

Abstract: The invention provides a method and kit for the separation and purification of cellular components including polar and non-polar metabolites, genomic DNA, RNA and proteins from a single biological sample where two steps of lysis of the cells are performed sequentially, before and after a metabolite isolation step. The first lysis step is mechanical and performed in order to be incomplete, whereas the second is chemical or both mechanical and chemical. A sequential isolation of genomic DNA, RNA and proteins is carried out after the second lysis step.

Abstract: Provided herein is a proximity assay that, in certain embodiments, involves: (a) hybridizing a first oligonucleotide and a second oligonucleotide with a target nucleic acid, wherein the first oligonucleotide comprises: i. a region that is complementary to a first sequence in the target nucleic acid and ii. a barcode sequence; and the second oligonucleotide comprises i. a region that is complementary to a second region in the target and ii. the complement of the barcode sequence; and (b) detecting hybridization between the barcode sequence and the complement of the barcode sequence, wherein hybridization between the barcode sequence and the complement of the barcode sequence indicates that the first and second target sequences are proximal to one another in the sample.

Abstract: The present invention relates to compositions on a FET sensor for detecting wide variety of biological entities. The composition of the FET sensor comprises a linker probe having a region for binding a biological entity, and enzymatic region that can cleave or change the position of a cargo molecule bound to the linker probe. The binding of the biological entity may cause a first strand of DNA to dehybridize from a second strand of DNA resulting in a change in conductance of the FET sensor. When the conformation of the probe changes, the conductance of the FET changes. This method provides an advantage over the conventional FET biosensors that use antibodies as probes since the size of nucleotide aptamer probes is smaller, their conformation/shape is well controlled, and their charge is fixed for a wider range of solution conditions, enabling robust detection of target entities with high sensitivity and specificity.

Abstract: Methods for extracting high quality nucleic acids from a heterogenous collection of nucleic acid-containing materials from a biological sample are disclosed. The heterogenous collection of nucleic-acid containing materials may contain cells or microvesicles, or both. The extractions obtained by the methods described herein are characterized by high yield and high integrity, making the extracted nucleic acids useful for various applications in which high quality nucleic acid extractions are preferred, e.g., a diagnosis, prognosis, or therapy evaluation for a medical condition.

Abstract: A method of elucidating the identity of an unknown metabolite comprising measuring amounts of known and unknown metabolites in subjects; associating the unknown metabolite with a specific gene from a gene association study; determining a protein associated with the specific gene and analyzing information for the protein; associating the unknown metabolite with concentrations and/or ratios of other metabolites in subjects; obtaining chemical structural data for the unknown metabolite; and using the information obtained to elucidate the identity of the unknown metabolite.

Abstract: The present disclosure relates generally to the field of epigenetics and in particular epigenetic profiles associated with a pathological condition. The present specification teaches screening of individuals and populations for epigenetic profiles associated with a pathological condition. Epigenetic profiles are disclosed from the following sites in the FMR1 gene: FREE3, intron 2, an intron, intron/exon boundary and/or splicing region downstream of intron 2, and a site within the FREE2 portion of intron 1 in combination with a FM. Epigenetic profiles are also disclosed from a region in the FMR genetic locus selected from an intron, intron/exon boundary, a splicing region or an intragenic region in combination with an expansion mutation. Kits and diagnostic assays are also taught herein as are computer programs to monitor changes in epigenetic patterns and profiles.

Abstract: Methods for enhancing the binding of oligonucleotide probes to DNA and RNA are disclosed. The methods make use of thermodynamic and kinetic effects to reduce probe mismatches and failure of complementary probes to bind to DNA and RNA templates. Mapping and sequencing of the probed DNA and RNA samples are contemplated herein.