Abstract: The methods and systems described herein may involve determining at least one lifeotype of at least one individual, analyzing the at least one lifeotype, and delivering content to at least one individual based on the analysis. The methods and systems described herein may involve providing a game, determining at least one lifeotype of at least one player of the game, analyzing the at least one lifeotype, and affecting the game play based on the analysis. The methods and systems described herein may involve providing an interactive space, determining at least one lifeotype of at least one individual in the space, analyzing the at least one lifeotype, and modifying at least one attribute of the space based on the analysis.

Abstract: A system is configured to receive voice emotion information, related to an audio recording, indicating that a vocal utterance of a speaker is spoken with negative or positive emotion. The system is configured to associate the voice emotion information with attribute information related to the audio recording, and aggregate the associated voice emotion and attribute information with other associated voice emotion and attribute information to form aggregated information. The system is configured to generate a report based on the aggregated information and one or more report parameters, and provide the report.

Abstract: An intelligent system that supports real-time and offline feedback based on automated analysis of a trainee's performance using data streams captured in the training process is disclosed.

Abstract: The present invention, in one embodiment, is a model and/or related kit for practicing surgical protocols in the maxillary and/or mandibular arch. The model and related kit comprises a base in the shape of at least a portion of a maxillary dental arch or mandibular dental arch including a defect on the surface of the base. The model and related kit also comprises a multi-layer tissue model configured to overlay at least a portion of the base in a covering relationship with the defect and surrounding tissue. The multi-layer tissue model includes an adhesive gingival simulating layer attached to an adhesive connective tissue simulating layer. The adhesive connective tissue simulating layer is configured to adhere the multi-layer tissue model to the base.

Abstract: A method of teaching patient care is provided. The method includes providing a medical simulator including a model of at least a portion of a human body. The simulator is configured to execute a simulated medical scenario. The method also includes defining a plurality of palette items, each of the plurality of palette items associated with a physiological state of the simulator, and defining at least one scenario, the at least one scenario including a series of linked palette items. The method also includes selecting a scenario for execution by the simulator, communicating the selected scenario to the simulator, and utilizing the simulator to execute the selected scenario.

Abstract: A human surrogate neck model includes a spinal neck region containing cervical vertebrae. A biosimulant intervertebral material is inserted between the cervical vertebrae. The spinal neck region is surrounded by a first silicone material mixed with a polymeric cross-linking inhibitor. One or more elastic tension bands are anchored to a top interface and a bottom interface of the neck model. A second silicone material mixed with a polymeric cross-linking inhibitor is applied to surround the spinal neck region and the first silicone material and to embed the tension bands. One or more of the elastic tension bands and/or a concentration ratio of the first silicone material or second silicone material to the polymeric cross-linking inhibitor can be adjusted for variable test conditions to closely simulate or mimic the static and dynamic characteristics of a human neck in various scenarios.

Abstract: The invention relates to an improvement and advanced use of the 12 hour and 24 hour insert/facing of the clock to aid as a teaching tool to inform the individual of the time of day or night each organ comes on shift. The insert/facing of the clock will aid in determining which organ is most effective during a certain time of the 24 hour day. The advantage of knowing this will aid in determining which organ is weak. Pain at certain times depicts deficiency/weakness. this invention can be used by professionals in the health arena or by individuals. It also tells the time of the day using the 24 hour clock or the 12 hour clock.

Abstract: A medical simulation model is provided for use in medical training, and having a wall defining a chamber, and having a slit in the wall providing access to the interior of the chamber. A pair of rib-cage members is located within the chamber such that adjacent edges of each member are spaced apart from each other. Resilient biasing elements are connected to each rib-cage member and configured such that adjacent edges of the rib-cage members may be brought into contact with each other, or further spaced-apart, against the action of the resilient biasing elements. A conduit is provided to enable fluid to be introduced into the chamber, and a facsimile of a mammalian heart is located within the chamber.

Abstract: The method assumes that a single solution or addition or subtraction of solutions of Schrodinger equation represented by polar or parabolic coordinates having its maximum value at the origin gives a wave function and an electric potential of a hydrogen atom. The method further: (1) regards the result of applying a gradient vector operation and thereafter a sign inversion to the wave function as an electric field; regards segments connected successively along the direction of the electric field as electric lines of force; and draws the electric lines of force so as to be approximately proportional in number to the percentage of the wave function with a difference between the maximum and minimum values of the wave function regarded as 100; and (2) displaying the wave function as an electric potential in a contour drawing.

Abstract: Disclosed herein is a multipurpose rotation structure which is installed indoors or outdoors to be utilized for multiple purposes such as experience teaching tools by using repelling force between magnets disposed in an outer ring frame having the shape of a ring and in a weight body rotating in an inner space of the outer ring frame, by particularly using repelling force between magnets disposed in a weight body and a second weight body placed on the same guide ring, or by using repelling force between magnets disposed in an outer ring frame and an inner ring frame that are opposite to each other with respect to a weight body, or by using attractive force and repulsive force between magnets while sequentially changing the polarity of electromagnets disposed in an outer ring frame and an inner ring frame.

Abstract: A system for tagging atomic learning units of instructional content and for dynamically generating a curriculum tailored to an individual using the tagged units is disclosed. The system includes a tagging module for tagging atomic learning units of instructional content with at least one standard and at least one level of rigor to form learning objects. The system further includes a learning objects database for storing the learning objects. The system further includes a dynamic curriculum generation module for dynamically generating a curriculum tailored to an individual by selecting individual learning objects from the database using the tags and for presenting the curriculum to the individual.

Abstract: Computer implemented methods, systems, and products uses learning cycles of individual and group work to emphasize the importance of collaborative behaviors and demonstrate the values of effective team work on outcomes. The computer implemented methods, systems, and products relate to team based learning with individual and group assessment for addressing a project or a problem, particularly to promote interaction between participants. In the computer implemented learning cycle, a team works as individuals and then as a group to determine responses to an overall project or problem. In addition to assessing the performance of the individuals and the determined individualized and overall responses, the computer implemented methods, systems, and products track the progress and activity of individuals and the team. Through the cycle of learning activities, individuals demonstrate personal responsibility, collaborative orientation, communication skills, conflict management, and problem solving.

Abstract: Disclosed herein are e-learning lesson delivery platforms, products, programs, and methods comprising a digital processing device and a program that creates a lesson delivery server, wherein said server comprises: a plurality of learning activities, wherein said activities are organized according to an instructional plan designed to accomplish one or more educational objectives in at least one subject, wherein said plan identifies one or more activities for use in a guided environment and one or more activities for assignment as independent work; a module for displaying and providing access to said one or more activities in a guided environment; a module for assigning said one or more activities as independent work to one or more learners, wherein said module is only accessible by a mentor; and a module for displaying and providing access to activities assigned as independent work, wherein said module is accessible by a mentor or a learner.

Abstract: A method for a response device to wirelessly communicate data in an audience response system having a plurality of response devices includes transmitting a first signal, receiving a first acknowledgement signal indicating to the response device to transmit non user selection signals. The method further includes transmitting a non user selection signal in response to the first acknowledgement signal and receiving a second acknowledgement signal indicating to the response device to cease transmitting non user selection signals.

Abstract: A computer-implemented method and apparatus for supporting decisions in sequential clinical risk assessment examinations, the method comprising receiving one or more first test results and a question, both associated with a patient; and assessing by a processor associated with a computing platform, information gain provided by a second test which may be performed for the patient, as the conditional mutual information between a second test and the question, using the first test result.

Abstract: A services-oriented system for knowledge assessment and learning performs a method of receiving a plurality of two-dimensional answers to a plurality of first multiple-choice questions, determining, after a period of time, which of the answered multiple choice questions remain unfinished and which are completed, separating the unfinished questions from the completed questions, determining which of the unfinished and completed questions to include in a mastery-eligible list of questions, assigning a weight to each of the mastery-eligible questions based on the current learning state of the learner, a target learning score of the learner, and a calculated dopamine level of the learner.

Abstract: An apparatus, method, and program product are provided for games for learning regulatory best practices. A display module presents a virtual learning environment for an organization associated with an industry sector. A gaming module presents a game within the virtual learning environment that is designed to train and/or test a user on regulations associated with the industry sector. A reporting module provides a graphical representation of results of the game. The results indicate understanding of the regulations.

Abstract: An educational tool is presented that provides a user with the ability to easily relate and understand how a complex subject's facts and concepts relate in a way which enhances the speed, ease, and depth a subject can be learned.

Abstract: A web-based educational system comprising at least one area of skill, interest, or expertise, a plurality of activities associated with each area of skill, interest, or expertise, and at least three navigational modes, wherein the navigational modes comprise a sequenced navigational mode, a guided navigational mode, and an independent navigational mode. Optionally, the learner can switch between available navigational modes.

Abstract: An electronic clipboard with an optional associated remote personal unit worn by a player. The clipboard can include a flat electronic unit with an optionally writeable flat display. The associated unit can be a wrist or other unit with a small display worn by a player. A protective cover can be pulled over the display to protect it during play. Plays from a library of plays, or plays written on the electronic clipboard, can be transmitted by radio to the remote personal unit and displayed. The electronic coach's clipboard that could store and recall images of plays that the coach could carry or have immediately available. Optionally real-time game photographs can be displayed on the coach's electronic clipboard.

Abstract: Active vibration isolation (AVVI) systems are becoming more available in various markets, one such market being vehicle operator seating. Unfamiliarity with the performance of such systems may cause users initial perceptions of system performance to be unfavorable. AVI systems can include a demonstration system capable of providing simulations too users of various types of vibration isolation systems under various input conditions, so that users can be introduced to the system benefits over other systems before using an AVI equipped product in its intended application.

Abstract: The present disclosure describes one or more systems, methods, routines and/or techniques for guiding a child (or other person) to perform tasks. The present disclosure may help children (or other people) perform various tasks (e.g., taking a shower) without a parent having to be present with the child during each task. One or more embodiments may describe a guidance device comprising a display and circuitry and/or computer code disposed in the guidance device. The display may show a figure with multiple parts. The guidance device may be operable to progress through multiple defined time segments. During each one of the multiple defined time segments, the guidance device may indicate one or more of the multiple parts of the figure that are associated with a sub-task that the user should perform. The guidance device may indicate completion progress of the time segment and the sub-task.

Abstract: The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.

Abstract: Disclosed herein is an RGD-enriched solubilized extracellular matrix composition derived from endothelial cell culture that can be used to modify the immunogenicity or thrombogenicity of an organ intended for transplant. The RGD-enriched solubilized extracellular matrix composition is applied to the lumen of the vasculature of the organ, thereby placing a barrier between the antigens on the lumenal surfaces of the transplanted organ and the blood of the recipient.

Abstract: The present invention relates to a solution for preservation, perfusion, and/or reperfusion of an organ, especially the heart, for transplantation. The solution contains peptide inhibitor(s) of protein kinase C ? (PKC ?). Methods for using the inventive solution are also disclosed, including methods for preserving an organ for transplantation, for protecting an ischemic organ from damage, for attenuating organ dysfunction after ischemia, for maintaining nitric oxide release and/or inhibiting superoxide release in an ischemic organ, and for protecting an organ from damage when isolated from the circulatory system.

Abstract: A donor organ treatment apparatus has a container for holding an organ and a perfusion liquid circuit. The perfusion circuit includes a supply conduit downstream of an oxygenator and a heat exchanger for supplying perfusion liquid from the oxygenator and the heat exchanger to an organ in the container and a return conduit upstream of the oxygenator and the heat exchanger for guiding perfusion liquid from the organ inside the container to the oxygenator and the heat exchanger. The supply conduit is provided with an outlet port coupling for connection to a perfusion catheter and the return conduit is provided with an inlet port coupling for connection to a return catheter. A method for successively perfusing an organ in-situ and ex-vivo with liquid circulating through the same perfusion circuit is also described.

Abstract: Disclosed herein are methods for cryopreserving cells and tissues under clinical conditions, allowing production of viable cell products suitable for transplantation.

Abstract: Disclosed are devices for collecting blood that contain an anti-coagulant and an additive that delays clotting by inhibiting the contact pathway for thrombin generation. The additive is a coagulation contact pathway inhibitor additive that is at least one of a Factor XI inhibitor, a Factor XII inhibitor, a kallikrein inhibitor and combinations thereof, each in an amount effective to mediate or suppress the contact pathway for thrombin generation. Methods of making and using the devices, and kits containing the devices, are also provided.

Abstract: This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique ?-N-acetylgalactosaminidases and ?-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique ?-N-acetylgalactosaminidases and ?-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof: (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells: and (iii) a favorable kinetic constant Km with mono- and oligosaccharide substrates.

Abstract: Provided herein are compositions and processes that allow for sensitive detection of up to fifteen individual HPV sequences or types in a single, multiplexed test. High risk types that can be detected are HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 73. Processes and compositions described herein are based in part on the presence or absence of HPV nucleic acid, including HPV DNA and RNA.

Abstract: Techniques for generating microtissues, including a micro-fabricated platform including at least one micro-well including a plurality of micro-cantilevers coupled thereto and surrounded by a plurality of ridges, each micro-cantilever including a cap at a terminal end thereof. The platform can be immersed in a suspension of cells. The suspension of cells can be driven into at least one micro-well, and the ridges can be de-wetted to remove excess suspension and isolate the suspension of cells in each micro-well. The cells can be driven in the suspension of each micro-well toward a top surface of the suspension, which can be polymerized to form a matrix. The cells can be cultivated to spontaneously compact the matrix such that the micro-cantilevers anchor and constrain the contracting matrix to form a band of microtissue that spans across the micro-cantilevers.

Abstract: A method of design and synthesis of a new drug. This invention may be used in human and veterinary medicine for the design of new drugs that are effective in the treatment of oncological and viral human and animal illnesses and for the design of new medicines. In the method a biopolymer target for the drug action is selected; then the quantity of nitrogen-containing positively charged groups available for modification is calculated. Biopolymer target may be cut into oligomer fragments. Some of calculated nitrogen-containing positively charged groups are substituted with negatively charged groups by combinatorial modification. The obtained supramolecular assemblies are used as drug for the biopolymer target.

Abstract: A device and method for particle separation. The device includes at least one collimated light source operable to generate at least one collimated light source beam. The device further includes a first channel in a first plane and a focused particle stream nozzle operably connected to the first channel. The device further includes a second channel in a second plane orthogonal to the first plane. The second channel communicates with the first channel. The second channel comprises a second channel cross-section. The second channel is oriented to receive the collimated light source beam. The device further includes a third channel in a third plane orthogonal to the second plane. The third channel communicates with the second channel. The collimated light source beam is oriented to enter a cross-section of the first channel, then to pass through the second channel, and then to enter a cross-section of the third channel.

Abstract: Disclosed are new and improved methods and systems for nucleic acid sequence analysis that can analyze data indicative of natural by-products of nucleotide incorporation events without the need for exogenous labels or dyes to identify nucleic acid sequences of interest. In particular, the methods and systems of the present teachings can process such data and various forms thereof to align fragments of the nucleic acid(s) of interest, particularly those analyzed using an addition sequencing technique, for example, as occurs with the use of nucleotide flows.

Abstract: This invention relates to a quantitative method for determining whether a human subject has an impaired DNA mismatch repair function; providing a diagnostic sample taken from said human and producing a nuclear extract from said sample; providing MMR proficient and MMR deficient nuclear extracts as positive and negative controls, respectively; combining each nuclear extract with at least one mismatch bearing substrate DNA molecule; performing a mismatch repair assay; and determining whether said sample nuclear extract is capable of repairing said substrate DNA molecule; wherein said sample comprises normal, non-malignant constitutive cells, such as fibroblasts. The invention further relates to a kit providing necessary reagents for use in said method.

Abstract: The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.

Abstract: Methods are provided for diagnosing in a subject a condition, such as a carcinoma, sarcoma or leukemia, associated with hypermethylation of genes by isolating the genes from tissue containing as few as 50 to 1000 tumor cells. Using quantitative multiplex methylation specific PCR (QM-MSP), multiple genes can be quantitatively evaluated from samples usually yielding sufficient DNA for analyses of only 1 or 2 genes. DNA sequences isolated from the sample are simultaneously co-amplified in an initial multiplex round of PCR, and the methylation status of individual hypermethylation-prone gene promoter sequences is then determined separately or in multiplex using a real time PCR round that is methylation status-specific. Within genes of the panel, the level of promoter hypermethylation as well as the incidence of promoter hypermethylation can be determined and the level of genes in the panel can be scored cumulatively. The QM-MSP method is adaptable for high throughput automated technology.

Abstract: Predictive biomarkers identify those patients suffering from immunoglobulin positive (Ig+) B lineage malignancies that are responsive to active immunotherapy, where the active immunotherapy comprises vaccination with a tumor-specific idiotype-immunogen. It is shown herein that patient responsiveness to the idiotype-immunogen is dependent upon the sequence of the immunogen, where an immunogen having a low number of tyrosine residues in the CDR1 (herein termed CDR1-Y10) regions of one or both of the immunogen heavy and light chains is predictive of a positive anti-tumor response, while a high number of CDR1 tyrosine residues (herein termed CDR1-Yhi) is predictive of a low anti tumor response.

Abstract: A fluid identification system comprising a plurality of particles, each particle encapsulating therein at least one tracer material having an identifiable DNA, the at least one tracer material being encapsulated by an encapsulation material, wherein the particles are adapted to retain the at least one tracer material in an encapsulated form after exposure of the particles to a temperature of at least 75° C. and/or a pressure of at least 1000 psi (6.9×106 N/m2).

Abstract: Seed coat color is a very important trait in oilseed type Brassica crops. Identification of the genes controlling the seed coat color is essential to the manipulation of these genes to develop new yellow-seeded germ plasm for oilseed breeding. The Brassica TTG1 and TT1 genes may be used to control seed color in plants.

Abstract: Disclosed herein are methods and materials for facilitating the detection of nucleic acid analytes of interest. Specifically exemplified herein are methods for detecting mycobacterial microorganisms, namely Mycobacterium avium spp. paratuberculosis. Also disclosed is new hybridizing magnetic relaxation nanosensor (hMRS) particularly adapted to detect a target nucleic acid analyte of interest.

Abstract: The invention concerns in vitro proteomic analysis of cells to determine the sensitizing potential (including allergic potential) of compounds on said cells. Several protein markers are provided that allow assays to be performed to determine whether a chemical has a sensitizing potential of contact and/or respiratory sensitizers.

Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r?s, RHD*DIIIa, RHD*DIVa-2, RHCE*css and RHCE*ce733G. The method comprises genotyping a sample obtained from a human subject at one or more positions in intron 7 of the RHD gene and/or in intron 7 of the RHCE gene. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.

Abstract: The disclosure provides methods and means for identifying plants comprising a plant phenotype of interest. In particular, the disclosure provides breeding tools that can be used for the selection of a plant comprising a phenotype of interest and for the selection of an optimal plant genotype for the introduction of a trait.

Abstract: Digital assay system, including methods and apparatus, for characterizing telomere length.

Abstract: The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Abstract: The present invention relates to detection of materials derived from transgenic plant events. In particular, the invention provides methods, reagents, kits and reference materials for detecting the presence or absence in a sample of genetic material derived from and attributable to select transgenic plant events.

Abstract: Various embodiments provide methods for the detection, the diagnosis, and/or the progression monitoring of Alzheimer's disease by observing the epigenetic markers in leukocytes. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate labeling the sample to identify at least one epigenetic marker; determining an amount of the at least one epigenetic marker; comparing the amount to a reference value; and determining a state of Alzheimer's disease.

Abstract: Disclosed embodiments concern a probe comprising one or more pairs of monomers capable of targeting a nucleic acid target. The pair of monomers may be arranged in a manner that promotes thermoinstability of the probe complex, thus producing a probe capable of locating and/or detecting a target. The probe also may comprise one or more natural or non-natural nucleotides capable of Watson-Crick base pairing with an isosequential nucleic acid target. Particular disclosed embodiments concern a method of using the disclosed probe to target nucleic acids. In particular disclosed embodiments, the probe may be incubated with a target nucleic acid and then be detected.

Abstract: The invention provides a method for fixing an RNA molecule in a biological sample. The method comprises contacting the biological sample with an aldehyde-containing fixative, and subsequently contacting the sample with a solution comprising a carbodiimide and a heterocyclic derivative selected from the group consisting of an imidazole, pyrazole, triazole or tetrazole or a combination thereof. A method for differentiating cells in a biological sample is also provided. A method for quantification of RNA retention in a biological sample is also provided. A kit for fixing RNA in a sample is provided as well.