Patents Issued in September 25, 2014
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Publication number: 20140286823Abstract: A decontamination system for decontaminating at least one contaminant in a process stream. Decontaminant liquid is dispersed into the process stream sing atomization. Differential injection pressure and/or injection flow rate are monitored to help ensure that the atomization process is optimized.Type: ApplicationFiled: September 24, 2013Publication date: September 25, 2014Inventor: Lance Witt
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Publication number: 20140286824Abstract: An automated analyzer maintains high processing capacity and dispensation accuracy even when items requiring dilution/pretreatment and general reaction measurement are mixed. A plurality of sample dispensing mechanisms are independently driven and each include a sample collection position, a sample nozzle for collecting the sample, and a washing tank for washing the sample nozzle. The sample dispensing mechanisms are configured to collect the sample from a plurality of sample collection positions and are operated independently to perform sample dispensation into reaction containers on a reaction disc. At least one of the sample dispensing mechanisms is provided for each of a sample requiring dilution/pretreatment and a sample that does not require dilution/pretreatment. The automated analyzer is provided with a control means for causing the respective mechanisms to be operated in a dedicated manner. The sample is dispensed such that no vacancy is created in the reaction containers.Type: ApplicationFiled: October 12, 2012Publication date: September 25, 2014Inventors: Akihiro Yasui, Yoshihiro Suzuki, Hitoshi Tokieda
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Publication number: 20140286825Abstract: The invention relates to a test strip. The test strip comprises an insulating sheet; a metallic circuit layer disposed on the insulating sheet, the metallic circuit layer including at least an electrode section; a sensing reagent layer provided on the electrode section; an intermediate layer disposed to cover the insulating sheet and the metallic circuit layer, the intermediate layer having an opening to expose the sensing reagent layer and the electrode section; and a cover disposed to cover the intermediate layer and the insulating sheet, and expose part of the metallic circuit layer, the cover having two holes corresponding to the opening. The test strip is provided in a combination of printing manner and chemical plating such as metallic ion replacement or electroless plating to form the metallic circuit layer readily so as to enhance the stability of resistance and the test accuracy.Type: ApplicationFiled: September 5, 2013Publication date: September 25, 2014Applicant: Ichia Technologies, Inc.Inventor: Ko-Ju CHEN
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Publication number: 20140286826Abstract: The invention relates to a cartridge (400), a sensor device, and a method for the optical examination of a sample. A first output light beam that originates from a total internal reflection at a detection surface of a TIR chamber and a second output light beam (L2?) that comes from the interior of an inspectable chamber (420) are both received within an observation region (OR). Preferably, these output light beams are detected with the same light detector, e.g. an image sensor. The invention hence allows for observing a total internal reflection at the TIR chamber and for looking into the inspectable chamber (420) from the same observation region (OR). This is for example enabled by different inclinations of the windows encountered by the first and the second output light beams, by different optical elements (407) in the paths of the output light beams, and/or by light scattering surface structures in the inspectable chamber.Type: ApplicationFiled: October 29, 2012Publication date: September 25, 2014Inventors: Jacobus Hermanus Maria Neijzen, Wendy Uyen Dittmer
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Publication number: 20140286827Abstract: An oxidation catalyst, an ozone injection nozzle, a urea-based fluid injection nozzle, and a selective reduction catalyst are arranged in an exhaust pipe of an engine in this order towards its outlet. An exhaust gas purifier includes an air flow sensor that detects an air intake amount of the engine, a NOx sensor that detects a NOx concentration in the exhaust pipe, and first and second temperature sensors that detect inlet temperatures of the catalysts. An ozone generation device to which the ozone injection nozzle is connected includes a compressor, a dryer that dries compressed air, a flow rate sensor that detects a flow rate of this air, an ozone generator that converts this air into ozone, and an ozone concentration sensor that detects a concentration of the ozone. A controller controls the compressor and the ozone generator based on respective detection outputs of the respective sensors.Type: ApplicationFiled: September 18, 2012Publication date: September 25, 2014Applicant: HINO MOTORS, LTD.Inventors: Yoshihiro Kawada, Asahiko Shimizu
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Publication number: 20140286828Abstract: An exhaust purification system of an internal combustion engine provided with an exhaust purification catalyst which reacts NOX and hydrocarbons. The exhaust purification catalyst includes an upstream side catalyst and a downstream side catalyst. The upstream side catalyst has an oxidation ability, while the downstream side catalyst carries precious metal catalyst particles on the exhaust flow surface and is formed with basic exhaust flow surface parts. The exhaust purification catalyst can make the concentration of hydrocarbons vibrate by within a predetermined range of amplitude and by within a predetermined range of period so as to partially oxidize the hydrocarbons or produce reducing intermediates at the upstream side catalyst. When the temperature of the upstream side catalyst is less than a first judgment temperature and the temperature of the downstream side catalyst is higher than a second judgment temperature, the temperature of the upstream side catalyst is made to rise.Type: ApplicationFiled: November 30, 2011Publication date: September 25, 2014Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Kazuhiro Umemoto, Kohei Yoshida, Mikio Inoue
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Publication number: 20140286829Abstract: An ammonia generating and delivery apparatus generating ammonia by heating a precursor material with a heating device controlled by a temperature pulse controller which receives commands from a pressure controller, and delivering ammonia with a flow rate controlled by a three-stage PWM controller. The temperature pulse controller is used in a first feedback loop to create a temperature pulse sequence at a surface of the heating device. A pressure controller in a second feedback loop provides duty-cycle commands to the temperature pulse controller, while in delivering ammonia, effects of pressure variation to delivery accuracy are compensated in the three-stage PWM controller, which includes a flow-rate feedback loop. The ammonia generating and delivery apparatus can also include two containers, in which the precursor material in one container is charged and discharged according to the capability of the other container in generating ammonia.Type: ApplicationFiled: March 8, 2014Publication date: September 25, 2014Inventor: Baohua Qi
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Publication number: 20140286830Abstract: A sanitizing device for toothbrushes is described. The device has a lower housing body, and a vessel for containing a sanitizing liquid being connected to the lower housing body in an upper position according to a vertical axis. The lower housing body has removable basins adapted to contain a head of the toothbrush substantially arranged along the vertical axis. The removable basins are hydraulically connected to the vessel for the controlled flowing down of the sanitizing liquid from the vessel to the basins. The removable basins The lower housing body is removably associated to a cap in an upper position according to the vertical axis, the cap being cup-shaped to enclose the vessel and possible portions of the toothbrush that project upwards from the lower body.Type: ApplicationFiled: October 11, 2012Publication date: September 25, 2014Inventors: Tommaso Biancalani, Clemente Biancalani
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Publication number: 20140286831Abstract: In one embodiment, a system for treating a gas stream comprising NOx generated from an acid pickling solution includes a first chamber and a second chamber. The first chamber includes a first inlet communicating with a source of a gas comprising NOx, a second inlet communicating with a source of ozone, and an interior volume adapted to contact the gas comprising NOx introduced through the first inlet with the ozone introduced through the second inlet. The second chamber directly fluidly communicates with the first chamber and receives gaseous effluent comprising nitric acid from the first chamber. The second chamber includes a third inlet communicating with a source of water vapor, an interior volume adapted to contact the gaseous effluent from the first chamber with the water vapor, thereby solubilizing nitric acid in the gaseous effluent with the water vapor to provide a solubilized nitric acid, and an outlet for collecting solubilized nitric acid from the interior volume of the second chamber.Type: ApplicationFiled: June 9, 2014Publication date: September 25, 2014Inventor: James A. Moore
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Publication number: 20140286832Abstract: An exhaust system is provided. The exhaust system includes an exhaust conduit having a protuberance thereon. A reductant injector is provided on the protuberance. The reductant injector is positioned such that an ejection tip of the reductant injector is inclined with respect to a centerline of the exhaust conduit. A baffle assembly is coupled to an inner wall of the exhaust conduit. The baffle assembly is positioned upstream of the ejection tip of the reductant injector. A first plate of the baffle assembly is positioned parallel to the centerline of the exhaust conduit. A second plate of the baffle assembly extends from the first plate. The second plate is positioned angularly with respect to the first plate. The baffle assembly is configured to deflect at least a portion of an exhaust gas flow over the ejection tip of the reductant injector.Type: ApplicationFiled: June 6, 2014Publication date: September 25, 2014Inventors: Yong Yi, Jinhui Sun, Arvind Jujare
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Publication number: 20140286833Abstract: A method and device for destroying and inhibiting exposure to microbes and infection includes a first element and a second element, and a power source. At least one of the elements includes antimicrobial metal, which, when energized by the power source, produces ions that are lethal to microbes. The device can be incorporated into virtually any useful object. During normal use of the object, electrical communication is established between the two elements, causing current supplied from the power source to flow through the antimicrobial metal. The two elements are configured and arranged to ensure that ions flowing from the antimicrobial metal flow through the region in which it is desired to kill microbes. The antimicrobial metal can be on the surface of the element, incorporated into the material making up the element, or provided in any other way that allows the antimicrobial effect to be achieved.Type: ApplicationFiled: November 26, 2013Publication date: September 25, 2014Applicant: ArgentumCidal Electrics, Inc.Inventors: Thomas A. FULLER, Richard WYSK, Wayne J. SEBASTIANELLI, Paul H. COHEN, Robert C. VOIGT
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Publication number: 20140286834Abstract: A system for separating liquids from solids comprising an immobilization unit comprising an immobilization vessel containing a bed of magnetizable material and a magnet configured to produce a magnetic field within the immobilization vessel, wherein the immobilization vessel further comprises an immobilization vessel outlet and an immobilization vessel inlet for a fluid comprising liquid and metal-containing particles.Type: ApplicationFiled: June 2, 2014Publication date: September 25, 2014Inventors: Sergio MOHEDAS, Harold A. Wright
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Publication number: 20140286835Abstract: A method of making a microfluidic diagnostic device for use in the assaying of biological fluids, whereby a layer of adhesive in a channel pattern is printed onto a surface of a base sheet and a cover sheet is adhered to the base sheet with the adhesive. The layer of adhesive defines at least one channel, wherein the channel passes through the thickness of the adhesive layer.Type: ApplicationFiled: June 9, 2014Publication date: September 25, 2014Inventor: Daniel J. Baril
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Publication number: 20140286836Abstract: A device for sampling and transporting nano-objects for analysis thereof. A cassette portion of the device includes two parts with mutual assembly mechanisms between them including a clipping mechanism configured not to be accessible from outside in assembled position of the parts. Therefore, any inopportune opening of the cassette and thus extraction of the sampling filter accommodated in the cassette somewhere else than the place intended for the analysis are avoided.Type: ApplicationFiled: October 5, 2012Publication date: September 25, 2014Applicants: NANOBADGE, Commissariat à l'energie atomique et aux ene altInventors: Simon Clavaguera, Eric Decolin, Guillaume Hebert, Jean-Loup Rechatin, Francois Tardif
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Publication number: 20140286837Abstract: A container for storing a biological sample for molecular diagnostic testing and/or histological testing is provided. The container includes a first chamber for receiving a sample holder therein, a second chamber, and a closure for enclosing the container. A breakable membrane, such as a piercable foil, extends within the container and separates the two chambers. When the breakable membrane is broken, fluid can pass between the first and second chambers. The membrane may be broken through an activator on the closure, such as a depressible member or a rotatable carrier, causing the sample holder to break through the membrane.Type: ApplicationFiled: June 5, 2014Publication date: September 25, 2014Inventors: Benjamin R. Bartfeld, C. Mark Newby
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Publication number: 20140286838Abstract: The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.Type: ApplicationFiled: June 9, 2014Publication date: September 25, 2014Inventors: Lars Winther, Marc Key, Kristopher Buchanan, John Favuzzi, Benno Guggenheimer
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Publication number: 20140286839Abstract: The present invention relates to a process for selectively removing molybdenum from a solution which contains molybdenum, said process comprising the following steps: bringing the solution to an acid pH lower than or equal to 3, preferably lower than or equal to 2, even more preferably lower than or equal to 0.Type: ApplicationFiled: November 25, 2011Publication date: September 25, 2014Applicant: Eni S.P.A.Inventors: Andrea Bartolini, Emilio Sentimenti
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Publication number: 20140286840Abstract: The present invention refers to a method being easy to recover metals including nickel and aluminum from waste aluminum catalysts, thereby entirely promoting the recovering rate. Said method comprises: preparing and roasting a waste aluminum catalyst with sodium salts, and then obtaining a first solution comprising vanadium and molybdenum, and a dreg comprising nickel and aluminum through leaching and filtrating; collecting and mixing the dreg with alkali powders to obtain a mixture of the dreg and alkali powders, roasting the mixture at 300 to 1000° C. with aluminum in the dreg reacting with hydroxyl generated from the roasting of mixture and further generating aluminum hydroxide, and then obtaining a second solution comprising aluminum and a concentrate having nickel through another leaching and filtrating; and recovering aluminum from the second solution and recovering nickel from the concentrate.Type: ApplicationFiled: May 7, 2013Publication date: September 25, 2014Inventor: Ping-Tao WU
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Publication number: 20140286841Abstract: There are provided methods for separating iron ions from aluminum ions contained in an acidic composition. The methods comprise reacting the acidic composition with a basic aqueous composition having a pH of at least 10.5 so as to obtain a precipitation composition, maintaining the precipitation composition at a pH above 10.5 so as to cause precipitation of the iron ions, at least substantially preventing precipitation of the aluminum ions, and to obtain a mixture comprising a liquid portion and a solid portion; and separating the liquid portion from the solid portion. There are also provided methods for treating an acidic composition comprising iron ions and aluminum ions. Such methods can be useful for preparing products such as alumina, aluminum, hematite etc.Type: ApplicationFiled: July 18, 2012Publication date: September 25, 2014Applicant: ORBITE ALUMINAE INC.Inventors: Richard Boudreault, Joël Fournier, Laury Gauthier
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Publication number: 20140286842Abstract: A method of mineralizing calcium from industrial waste comprising extracting calcium ions from a suspension of calcium rich granular particles and aqueous ammonium chloride to form a calcium-rich first fraction and a heavy second fraction. The heavy second fraction is separated from the first fraction and the calcium-rich first fraction is carbonated with a gas comprising carbon dioxide to form a suspension of precipitated calcium carbonate and aqueous ammonium chloride. The precipitate is separated from the aqueous ammonium chloride by centrifugal means and the separated heavy second fraction comprises an enriched weight percent of iron.Type: ApplicationFiled: June 3, 2014Publication date: September 25, 2014Applicant: COREX MATERIALS, INC.Inventor: Frank A. KARBARZ
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Publication number: 20140286843Abstract: A fluid filtration apparatus, which includes a plurality of optical fibers each having a length, wherein one or more of the plurality of optical fibers exhibits frustrated total internal reflection, thereby emitting light along the length of one or more of the optical fibers, in combination with a photocatalyst disposed on the plurality of optical fibers and a light source interconnected to the plurality of optical fibers.Type: ApplicationFiled: March 17, 2014Publication date: September 25, 2014Inventors: Craig Grossman, Charles Geoffrion
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Publication number: 20140286844Abstract: Provided herein are sorbents for carbon dioxide (CO2) capture, such as from natural gas and coal-fired power plant flue gases, and uses thereofType: ApplicationFiled: March 14, 2014Publication date: September 25, 2014Inventors: Jennifer Wilcox, T. Daniel P. Stack, Zhenan Bao, Brannon Gary, Jiajun He, John To
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Publication number: 20140286845Abstract: This method for removing nitrogen oxides brings exhaust gas containing oxygen and at least one nitrogen oxide selected from the group consisting of nitrogen monoxide and nitrogen dioxide into contact with ammonia without the presence of a catalyst, for at least 0.5 seconds under a temperature of no less than 900 DEG C., and breaks down the nitrogen oxide. According to this method, it is possible to remove nitrogen oxides in a highly efficient manner and significantly reduce the amount of unreacted ammonia.Type: ApplicationFiled: November 2, 2012Publication date: September 25, 2014Applicant: Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.)Inventors: Takeshi Yamashita, Katsuya Akiyama, Noriaki Mizutani
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Publication number: 20140286846Abstract: A process for preparing a mesoporous metal oxide, i.e., transition metal oxide, Lanthanide metal oxide, a post-transition metal oxide and metalloid oxide. The process comprises providing a micellar solution comprising a metal precursor, an interface modifier, a hydrotropic ion precursor, and a surfactant; and heating the micellar solution at a temperature and for a period of time sufficient to form the mesoporous metal oxide. A mesoporous metal oxide prepared by the above process. A method of controlling nano-sized wall crystallinity and mesoporosity in mesoporous metal oxides. The method comprises providing a micellar solution comprising a metal precursor, an interface modifier, a hydrotropic ion precursor, and a surfactant; and heating the micellar solution at a temperature and for a period of time sufficient to control nano-sized wall crystallinity and mesoporosity in the mesoporous metal oxides. Mesoporous metal oxides and a method of tuning structural properties of mesoporous metal oxides.Type: ApplicationFiled: September 25, 2013Publication date: September 25, 2014Applicant: UNIVERSITY OF CONNECTICUTInventors: Steven L. Suib, Altug Suleyman Poyraz
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Publication number: 20140286847Abstract: A method of producing silica from geothermal fluid containing concentration of the silica of less than 1000 ppm includes the steps of treating the geothermal fluid containing the silica by reverse osmosis treatment thereby producing a concentrated fluid containing the silica, seasoning the concentrated fluid thereby producing a slurry having precipitated colloids containing the silica, and separating the silica from the slurry.Type: ApplicationFiled: June 6, 2014Publication date: September 25, 2014Inventor: William L. Bourcier
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Publication number: 20140286848Abstract: The invention relates to a process for producing hydrogen-containing chlorosilanes by reducing Si-based deposits of solid material during the operation of a pressurised reactor comprising one or more reaction spaces, wherein at least one organochlorosilane is reacted with hydrogen in at least one of these reaction spaces for at least some of the time, characterized in that at least one of the optionally two or more reaction spaces in which this reaction takes place is supplied with additional HCl for at least some of the time. The additional HCl is preferably produced by hydrodehalogenation of silicon tetrachloride with hydrogen in at least one of the optionally two or more reaction spaces of the reactor.Type: ApplicationFiled: January 27, 2012Publication date: September 25, 2014Applicant: Evonik Degussa GmbHInventors: Yücel Önal, Guido Stochniol, Jörg Sauer, Ingo Pauli, Norbert Schladerbeck
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Publication number: 20140286849Abstract: Mixtures of ammonia and ionic liquids are provided that are suitable for use as absorption cooling fluids in absorption cycles, and ammonia storage.Type: ApplicationFiled: June 3, 2014Publication date: September 25, 2014Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: MARK BRANDON SHIFLETT, AKIMICHI YOKOZEKI
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Publication number: 20140286850Abstract: A method of making sodium carbonate and/or sodium bicarbonate is disclosed in which carbon dioxide gas is reacted with an aqueous solution sodium hydroxide solution in the presence of a compound of the formula (I): Na+[X—O]? where X is Cl, Br, or I.Type: ApplicationFiled: August 30, 2013Publication date: September 25, 2014Applicant: New York Synthetics, Inc.Inventors: Richard L. Peterson, Luke Ice, Omar Bradley Sheikh, Omar Ayaz Hussein, Vasilios Spiridon Koutsogiannis
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Publication number: 20140286851Abstract: A combinatorial synthesis of the diamond unit cell is disclosed wherein a carbon atom free of meta-stable radical impurities reacts with cyclic hydrocarbon compounds or heterocyclic compounds whose structure is tetrahedral or nearly tetrahedral. Reactions conducted in the vapor phase and in the solid state are disclosed.Type: ApplicationFiled: May 28, 2014Publication date: September 25, 2014Inventor: Daniel Hodes
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Publication number: 20140286852Abstract: A method for producing carbon nanotubes having specific lengths, said method comprising: producing carbon nanotubes having at least two types of zones along their lengths, wherein each zone type has a characteristic structure that confers specific properties; and processing said carbon nanotubes to selectively attack one zone type more aggressively than another zone type.Type: ApplicationFiled: March 19, 2014Publication date: September 25, 2014Inventors: Nolan Nicholas, David Carnahan
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Publication number: 20140286853Abstract: Processes and systems for recovering bromine. A process may comprise contacting a gas stream comprising bromine with a liquid bromide stream comprising bromide anions to produce at least an off-gas stream that is substantially bromine free and a liquid stream comprising bromine anionic complexes; and heating at least a portion of the liquid stream to produce at least bromine from at least a portion of the bromine anionic complexes.Type: ApplicationFiled: March 17, 2014Publication date: September 25, 2014Applicant: MARATHON GTF TECHNOLOGY, LTD.Inventor: John J. Waycuilis
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Publication number: 20140286854Abstract: Discharge water from a coal mine, and/or water from an abandoned coal mine, is used as a source of sulfate ions to precipitate barium from gas well hydrofracture wastewater.Type: ApplicationFiled: June 3, 2014Publication date: September 25, 2014Applicant: ProChemTech International, Inc.Inventor: Timothy Edward Keister
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Publication number: 20140286855Abstract: A catalyst comprising: a platinum group metal, silver, gold, or a mixture thereof, and a carrier containing an oxide other than zirconium oxide and a precipitate layer of zirconium oxide onto the oxide other than zirconium oxide, as well as their uses in production of hydrogen peroxide. A process for producing hydrogen peroxide, comprising reacting hydrogen and oxygen in the presence of such catalyst in a reactor, and a process for producing such catalyst.Type: ApplicationFiled: October 26, 2012Publication date: September 25, 2014Inventors: Frédérique Desmedt, Paul Deschrijver, Yves Vlasselaer, Francine Janssens
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Publication number: 20140286856Abstract: A hydrogen storage method is provided which enables a hydrogen storage alloy to store hydrogen up to a maximum hydrogen storage amount thereof in excess of a generally known theoretical value. In a hydrogenation step, a hydrogen storage ratio calculated as an atomic weight ratio between hydrogen and the hydrogen storage alloy is obtained beforehand as a theoretical value, a pressure at which the hydrogen storage alloy stores hydrogen up to the theoretical value is set as a first pressure value, a pressure value ten or more times greater than the first pressure value is set as a second pressure value, and pressure is increased up to the second pressure value. In a dehydrogenation step, the pressure is decreased from the second pressure value to or below the first pressure value. The hydrogenation step and the dehydrogenation step are repeatedly executed.Type: ApplicationFiled: October 25, 2012Publication date: September 25, 2014Inventors: Naoki Uchiyama, Tomomi Kanai, Kazumi Harada
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Publication number: 20140286857Abstract: A method of preparing a metal containing inorganic ion exchanger in an electrochemical cell is disclosed. In one embodiment, the method comprises: (a) adding the inorganic ion exchanger to the electrochemical cell, wherein the electrochemical cell comprises a conductive electrolyte solution having a liquid phase and a solid phase; (b) depositing metal ions electrochemically into the liquid phase; (c) allowing the metal ions to deposit onto the inorganic ion exchanger during an electrochemical reaction to obtain a metal containing inorganic ion exchanger; (d) collecting the solid phase comprising the metal containing inorganic ion exchanger obtained in step (c); (e) removing remaining metal ions from the liquid phase; and (f) obtaining a substantially metal free liquid phase.Type: ApplicationFiled: March 13, 2014Publication date: September 25, 2014Applicant: BASF CORPORATIONInventors: Ahmad Dehestani, Gerald Koermer, Mukta Rai
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METHOD FOR INDUCING AN IMMUNE RESPONSE FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASES OR CONDITIONS
Publication number: 20140286858Abstract: The invention is related to peptide constracts, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of cancer or the treatment of autoimmune diseases and compositions containing same, methods for producing same, and methods for using same: wherein the peptide constructs have the formula P1-x-P2 where P2 is a peptide associated with forms of cancer or an autoimmune condition and P1 is a peptide which will bind to a class of immune cells such as dendritic cells. The peptide construct can cause the maturation of immature dendritic cells to a more mature state. The peptide construct or the more mature dendritic cells can be administered to a subject to a modulate or to initiate an immune response against cancer cells, and can be sued with dyes, radioisotopes, or therapeutic agents for detection of the immune target and/or treatment of cancer and autoimmune conditions.Type: ApplicationFiled: May 24, 2012Publication date: September 25, 2014Applicant: CEL-SCI CORPORATIONInventors: Daniel H. Zimmerman, Eyal Talor, Kenneth Steven Rosenthal -
Publication number: 20140286859Abstract: The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.Type: ApplicationFiled: September 10, 2012Publication date: September 25, 2014Applicants: PSMA Development Company, LLC, Amgen Fremont Inc.Inventors: Paul J. Maddon, Gerald P. Donovan, William C. Olson, Norbert Schuelke, Jason Gardner, Dangshe Ma, Jaspal S. Kang, Larry Green
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Publication number: 20140286860Abstract: The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.Type: ApplicationFiled: April 22, 2014Publication date: September 25, 2014Applicant: IMMUNOMEDICS, INC.Inventors: Serengulam V. Govindan, Sung-Ju Moon, David M. Goldenberg
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Publication number: 20140286861Abstract: This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.Type: ApplicationFiled: April 23, 2014Publication date: September 25, 2014Applicant: IMMUNOMEDICS, INC.Inventors: Serengulam V. Govindan, Zhengxing Qu, Hans J. Hansen, David M. Goldenberg
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Publication number: 20140286862Abstract: The present application provides an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein (for example, PSA or hK2) for use in the treatment of prostate cancer, and a method for the treatment of prostate cancer in a patient, the method comprising the step of administering a therapeutically effective amount of an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein to the patient.Type: ApplicationFiled: October 26, 2012Publication date: September 25, 2014Inventors: Sven-Erik Strand, Amanda Thuy Tran, Sven-Niklas Anders Axelsson
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Publication number: 20140286863Abstract: The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.Type: ApplicationFiled: December 3, 2013Publication date: September 25, 2014Applicant: The University of the Sciences in PhiladelphiaInventors: Zhlyu LI, Russell DIGATE
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Publication number: 20140286864Abstract: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 ?M), and dimer and multimeric constructs comprising these polypeptides.Type: ApplicationFiled: December 17, 2013Publication date: September 25, 2014Applicants: Bracco Suisse SA, Dyax Corp.Inventors: AARON K. SATO, DANIEL J. SEXTON, DANIEL T. DRANSFIELD, ROBERT CHARLES LADNER, CHRISTOPHE ARBOGAST, PHILIPPE BUSSAT, HONG FAN, SUDHA KHURANA, KAREN E. LINDER, EDMUND R. MARINELLI, PALANIAPPA NANJAPPAN, ADRIAN D. NUNN, RADHAKRISHNA K. PILLAI, SIBYLLE POCHON, KONDAREDDIAR RAMALINGAM, AJAY SHRIVASTAVA, BO SONG, ROLF E. SWENSON, MATHEW A. VON WRONSKI, FENG YAN
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Publication number: 20140286865Abstract: This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the CNS. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention.Type: ApplicationFiled: February 18, 2014Publication date: September 25, 2014Applicant: The Regents of the University of CaliforniaInventors: Timothy J. Deming, Michael V. Sofroniew, Chu-Ya Yang, BingBing Song, Yan Ao
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Publication number: 20140286866Abstract: The invention relates to compounds suitable for use in an imaging agent said imaging agent showing an improved pharmacokinetic profile.Type: ApplicationFiled: June 4, 2014Publication date: September 25, 2014Applicant: GE HEALTHCARE ASInventors: ALAN CUTHBERTSON, MAGNE SOLBAKKEN
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Publication number: 20140286867Abstract: The invention describes methods of treating erosive polyarthritis comprising administering a TNF? antibody, or antigen-binding portion thereof. The invention also describes a method for testing the efficacy of a TNF? antibody, or antigen-binding portion thereof, for the treatment of erosive polyarthritis.Type: ApplicationFiled: April 30, 2014Publication date: September 25, 2014Inventors: Rebecca S. Hoffman, Mark Weinberg
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Publication number: 20140286868Abstract: Immortalized human cell lines derived from prostate cells are disclosed. Immortalized cells derived from a human epithelial prostate tissue cancer tumor are provided, as well as immortalized cells derived from healthy human epithelial prostate tissue from the same patient. Methods for utilizing such immortalized cell lines for researching, screening, and evaluating antimalignancy therapies and drug candidates are also disclosed.Type: ApplicationFiled: June 5, 2014Publication date: September 25, 2014Applicant: TUSKEGEE UNIVERSITYInventors: Clayton Yates, Timothy Turner
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Publication number: 20140286869Abstract: The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity.Type: ApplicationFiled: June 5, 2014Publication date: September 25, 2014Inventors: Kenneth Harris, Dalip Sethi, Venkatesh Ponemone, Gary R. Cohan
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Publication number: 20140286870Abstract: The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity.Type: ApplicationFiled: June 5, 2014Publication date: September 25, 2014Inventors: Kenneth Harris, Dalip Sethi, Venkatesh Ponemone, Gary R. Cohan
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Publication number: 20140286871Abstract: The subject technology relates generally to compositions and methods for producing plasmid DNA of a desired quality. In addition, it relates to the discovery of Escherichia coli (E. coli) bacteria with a constitutive methylase gene stably incorporated into the chromosomal DNA and uses thereof.Type: ApplicationFiled: September 21, 2012Publication date: September 25, 2014Inventor: Alan P. Escher
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Publication number: 20140286872Abstract: Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O6-benzylguanine is covalently coupled, compositions that include the nanoparticle, and methods for using the nanoparticle to treat brain cancers.Type: ApplicationFiled: March 21, 2014Publication date: September 25, 2014Applicant: University of Washington through its Center for CommercializationInventors: Miqin Zhang, Richard G. Ellenbogen, Forrest Kievit, John R. Silber, Zachary Stephen, Omid Veiseh