Patents Issued in September 25, 2014
  • Publication number: 20140287373
    Abstract: A device for heating a substrate according to a predetermined temperature profile for crystallizing a material on the substrate includes: a housing, at least a process chamber situated inside the housing and provided with a first and second opening for passing through a substrate, an inlet for introducing a process gas which includes the material in vapour phase into the chamber, at least two transport rollers attached to the housing for transporting the substrate into the chamber. The device further includes passage spaces for preventing the escape of process gas from the chamber to a space between the chamber and housing, which are situated near respective ends of the transport rollers in the chamber, the respective passage spaces having a first passage opening on an inner wall of the chamber, a second passage opening on an outer wall of the chamber and a first flange fixed around the transport roller.
    Type: Application
    Filed: October 25, 2012
    Publication date: September 25, 2014
    Inventors: Gerard Kaper, Wiro Rudolf Zijlmans
  • Publication number: 20140287374
    Abstract: The present invention relates to a cartridge-type inline heater including: a heat exchanging unit including a body part in which a mounting part is formed in a longitudinal direction, and swirl parts coiled in a spiral along the longitudinal direction of the body part, and configured to induce a flowing-in working fluid to flow along the swirl parts; and a heater inserted in a longitudinal direction of the heat exchanging part to heat the working fluid which is in contact with the heat exchanging unit. Accordingly, the cartridge-type inline heater capable of heating the working fluid so as to have improved durability and uniform temperature distribution is provided.
    Type: Application
    Filed: November 16, 2012
    Publication date: September 25, 2014
    Applicant: KOREA INSTITUTE OF MACHINERY & MATERIALS
    Inventors: Jung Ho Lee, Kong Hoon Lee, Seok Ho Yoon, Young Kim
  • Publication number: 20140287375
    Abstract: A heat insulation structure, which has a cylindrical side wall part formed in a multilayer structure, includes: a cooling gas supply port provided in an upper portion of a side wall outer layer disposed in an outer side of the side wall part; a cooling gas passage provided between a side wall inner layer disposed in an inner side of the side wall part and the side wall outer layer; a space provided in an inner side of the side wall inner layer; a plurality of blowout holes provided in the side wall inner layer for distributing cooling gas from the cooling gas passage to the space; a buffer area continuously provided in the cooling gas supply port and the cooling gas passage; and a throttle part configured to reduce a cross-sectional area of a boundary surface between the buffer area and the cooling gas passage.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 25, 2014
    Applicant: HITACHI KOKUSAI ELECTRIC INC.
    Inventors: Tetsuya KOSUGI, Motoya TAKEWAKI, Hitoshi MURATA, Masaaki UENO
  • Publication number: 20140287376
    Abstract: Bracket guide features and use of such features to guide placement of orthodontic brackets.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 25, 2014
    Inventors: Bruce Willard Hultgren, Michael Craig Marshall
  • Publication number: 20140287377
    Abstract: A dental implantation system is provided, comprising an implantation device adapted to prepare a site within a mouth of a patient for receiving a dental implant. A guidance device is operably engaged with the implantation device and is adapted to operably engage the mouth of the patient. The engagement between the guidance device and the mouth of the patient provides a fiducial marker for guiding the implantation device to prepare the site for receiving the dental implant. An associated method of implanting a dental implant, and associated devices, are also provided.
    Type: Application
    Filed: June 5, 2014
    Publication date: September 25, 2014
    Inventors: Juan Ricardo Salcedo, Federico Grande
  • Publication number: 20140287378
    Abstract: Embodiments of the present invention include dental curing lights comprising a battery, and a fire resistant mesh bag at least partially enclosing the battery therein. Additionally, the battery and fire resistant mesh bag may be located within the dental curing light. Additional embodiments of the present invention include methods of manufacturing a dental curing lights. The methods may comprise enclosing a battery within a fire resistant mesh bag, and positioning the battery and fire resistant mesh bag into the dental curing light.
    Type: Application
    Filed: March 25, 2014
    Publication date: September 25, 2014
    Applicant: CAO GROUP, Inc.
    Inventor: Steven D. Jensen
  • Publication number: 20140287379
    Abstract: An apparatus including a bite frame and a bite shaped member is provided. The bite frame includes one or more arcuate frame elements defining an opening for accommodating a mesh element or the bite shaped member that receives a bite registration material for registering a bite impression. The bite shaped member has a geometrical body structure, upper and lower channels of configurable shapes, and upper and lower windows. The upper and lower windows are separated by a space for receiving and allowing flow of the bite registration material to register a vertical distance between the upper and lower jaws. An image processing system operably connected to the apparatus determines the three-dimensional relation between the upper and lower jaws with reference to temporomandibular joints using panoramic images of the upper and lower jaws, reference points provided by radio-opaque markers, three-dimensional scanned images of the bite impression, and three-dimensional head surface images.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 25, 2014
    Applicant: Hankookin, Inc.
    Inventors: James Jiwen Chun, Andrew Youngho Chun, Angela Soyoung Chun, Jennifer Miseong Chun
  • Publication number: 20140287380
    Abstract: The invention provides an orally acceptable plaque indicator gel comprising a dye in sufficient concentration to visibly stain plaque upon application, optionally for use in combination with an orally acceptable plaque removal gel comprising an antiplaque agent in sufficient concentration to remove plaque and or kill bacteria upon application, in each case the gel having a specific viscosity permitting efficient application using a pen dispenser, as well as reduced dye or antiplaque agent concentration, together with methods of using the same.
    Type: Application
    Filed: November 15, 2011
    Publication date: September 25, 2014
    Applicant: COLGATE-PALMOLIVE COMPANY
    Inventors: Elva Chen, Sharon Kennedy, Yelloji-Rao Mirajkar, Suzanne Jogun, Michael Prencipe
  • Publication number: 20140287381
    Abstract: An application for an adaptive training system includes a computer interfaced to one or more graphics displays, one of more input/output devices and having access to a plurality of training segments. The input/output devices are in communication with a trainee. Software operates in either a simulation mode in which a trainee interacts with the adaptive training system as if the trainee was operating a target vehicle or in a training mode in which the trainee receives computer-based training from the adaptive training system, in particular, when the trainee does not perform well during the simulation mode of operation.
    Type: Application
    Filed: May 22, 2014
    Publication date: September 25, 2014
    Applicant: ADVANCED TRAINING SYSTEM LLC
    Inventors: Aaron M. Best, J. Ken Barton, David J. Havell, Reginald T. Welles, Darrell R. Turpin, James W. Voorhees, John Kearney, SR., Camille B. Price, Nathan P. Stahlman, Aaron J. Turpin, Aaron M. Purvis
  • Publication number: 20140287382
    Abstract: The invention relates to a board for blind persons, which makes it easier to write, draw and learn shapes through positive relief elements that can be reused. When writing or drawing, it is possible to check what has been done and to correct errors detected with the fingertip (4). Said board has a grid (3) for picking up, putting down and storing small-size relief elements (1). Said relief elements are placed on a panel (2) with a matrix of holes, forming letters and drawings. There is a means for making copies of what was written or drawn. Drawing tools or stencils that can be attached with pins to the matrix of the panel are provided. Once the activity is finished, there is a means of collecting the relief elements and storing same in the container in the panel or the grid.
    Type: Application
    Filed: August 3, 2012
    Publication date: September 25, 2014
    Applicant: KAPARAZOOM, S.L.U.
    Inventor: Javier Villar Cloquell
  • Publication number: 20140287383
    Abstract: A scoring server for assessing technical skills in a practical environment. A client application acts as a middle man between a terminal and an operating system to capture and forward all input from and output to students to the scoring server. The scoring server compares recorded student activity against a list of tasks deemed capable of accomplishing course objectives assigned to students. As objectives are met by a student, the students' grade is updated in real-time. Each student passes or fails an exam based on tasks performed and skills employed. The client application exists for two operating system types: windows and LINUX. A LINUX client employs a pseudoterminal to permit access to terminal input/output and communication through stdin, stdout, and stderr channels. A windows client (WC) comprises a WC command line activity logger and a WC monitor process to intercept all communication through stdin, stdout, and stderr communication channels.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 25, 2014
    Applicant: TeleCommunications Systems, Inc.
    Inventors: Jeremy Willingham, Brendan Watters, Anthony Hendricks, Brian Reider, Rob Odom, Robert Ledesma
  • Publication number: 20140287384
    Abstract: A system having an incorporated software program attempts to tailor a person's diet with the person's desired nutritional goal and their current food consumption. The system provides food exchange lists to assist a person making food choices from a category of food.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Inventor: Jeffery Boyes
  • Publication number: 20140287385
    Abstract: This invention relates an enunciation device comprising a hollow device shaped in a manner to fit a mouth. This enunciation device assists with improving enunciation, slowing speech, and strengthens mouth, tongue, and jaw muscles so that a user can build confidence while speaking.
    Type: Application
    Filed: November 21, 2012
    Publication date: September 25, 2014
    Inventor: Daniel G. Floyd
  • Publication number: 20140287386
    Abstract: The present invention is a teaching and learning tool built on the principle that the human sense of touch makes a significant contribution in the visualization of objects. Sighted individuals can produce visual images inside the brain (commonly referred to as the “mind's eye”) via the sense of touch, where we use our minds, rather than our eyes, to visualize concrete objects allowing us to “get a picture” of that object. A “brain-sight” apparatus is disclosed that provides a box for containing object manipulatives and/or math manipulatives, two openings for receiving hands of a user, which openings are covered by a veil such that the user cannot see into the box. A user who places his hands into the box and manipulates the object manipulatives and/or math manipulatives in response to a posed problem, and then solves the posed problem in a traditional manner, benefits from cognitive enhancement provided by multi-modal stimulation of the somatosensory cortex and lateral occipital cortex.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 25, 2014
    Inventor: Kenneth Wesson
  • Publication number: 20140287387
    Abstract: Systems and methods are provided for assessing, monitoring and predicting a person's emotive state based on the person's day-to-day social and physical activity, including biometric, geospatial and other data, and storing the emotive state in a form that can be used by others to enhance interaction with the person. Such interaction may be in the form of downloadable application, such as a video game, in which the play interaction is altered based upon the detected emotive state of the player.
    Type: Application
    Filed: March 22, 2014
    Publication date: September 25, 2014
    Applicant: EMOZIA, INC.
    Inventors: ALEKSANDAR VUKASINOVIC, Andrew Maxwell Fooden
  • Publication number: 20140287388
    Abstract: A system for training and reviewing gymnast skills. A student performs a sequence of gymnastic maneuvers in front of a screen and a motion-capturing camera. The sequence of movements are captured by the camera and analyzed. The captured movements are projected alongside an animated silhouette character performing the defined movements of the gymnastic maneuver in sequence.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 25, 2014
    Inventor: Jenna Ferrier
  • Publication number: 20140287389
    Abstract: Virtual reality-based adaptive systems and methods are disclosed for improving the delivery of physical therapy and rehabilitation. The invention comprises an interactive software solution for tracking, monitoring and logging user performance wherever sensor capability is present. To provide therapists with the ability to observe and analyze different motion characteristics from the exercises performed by patients, novel visualization techniques are provided for specific solutions. These visualization techniques include color-coded therapist-customized visualization features for motion analysis.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Marcelo Kallmann, Carlo Camporesi, Jay Han
  • Publication number: 20140287390
    Abstract: This invention relates to a device for controlling of movement of limbs of a user in a substantially mirror symmetrical manner, a user's limb or limbs being held in position via support arms, said device comprising a bar (or bars) adapted to move about a point of rotation, said bar (or bars) having a first end and a second end, said ends separated by the point of rotation, a first support arm(s) operatively coupled at or towards one end of said bar and a second support arm(s) operatively coupled at or towards a different end of the bar wherein the first and second support arms are adapted to substantially support and/or hold the limbs of a user of said device, the first and second support arms and the bar (or bars) configured such that, in use, as the bar (or bars) rotate(s) the support arms move in a substantially tandem synchronised manner with respect to each other.
    Type: Application
    Filed: April 15, 2014
    Publication date: September 25, 2014
    Applicant: Auckland Uniservices Limited
    Inventors: Winston Dean John Byblow, James William Stinear, Raymond Wayne Prikkel
  • Publication number: 20140287391
    Abstract: A method and system is provided for training athletes using films or videotapes of game situations so that a player's reaction can be applied to such situations. The videos are taken from the player's eye-level perspectives on the field or court. The method and system can be used for various sports, including basketball, football, baseball, hockey, soccer, volleyball, wrestling, and any other sport, particularly team sports. Using this system and method of the present invention will enhance and expedite training of athletes.
    Type: Application
    Filed: June 6, 2014
    Publication date: September 25, 2014
    Inventor: Curt Krull
  • Publication number: 20140287392
    Abstract: Provided is a board game instrument for learning. The board game instrument includes at least two projectiles, a launch pad, at least two baskets, a game board, and at least two magic cards. The projectiles are thrown in a basket using a launch pad. The launch pad launches the projectile using an elastic force. The baskets are formed to be concave so as to hold the projectile launched from the launch pad and have a rim of a top surface and a bottom surface thereof formed to be flat. The game board includes an area in which the baskets are placed, and is configured such that at least three baskets acquired in a game are stacked up into a pyramid of two or more tiers on the area.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 25, 2014
    Applicant: Korea Board Games Co., Ltd.
    Inventor: Gil-Oh KIM
  • Publication number: 20140287393
    Abstract: A system to assist in at least one of the evaluation of or the improvement of skills to perform minimally invasive surgery includes a minimally invasive surgical system, a video system arranged to record at least one of a user's interaction with the minimally invasive surgical system or tasks performed with the minimally invasive surgical system, and a data storage and processing system in communication with the minimally invasive surgical system and in communication with the video system. The minimally invasive surgical system provides at least one of motion data, ergonomics adjustment data, electrical interface interaction data or mechanical interface interaction data of at least a component of the minimally invasive surgical system in conjunction with time registered video signals from the video system.
    Type: Application
    Filed: May 6, 2011
    Publication date: September 25, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Rajesh Kumar, Gregory D. Hager, Amod S. Jog, David D. Yuh
  • Publication number: 20140287394
    Abstract: Brushing systems include a base configured to assist in keeping the system in an upright position. The base is coupled to a stand being sized, shaped, and positioned so as to couple the base and a support structure. The support structure is configured to provide support for a audio/video device positioned thereon, the audio/video device being configured to provide an audio/visual presentation to a child while brushing his or her teeth, the audio/visual presentation including information on proper oral hygiene habits.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 25, 2014
    Applicant: My Pet Flag, LLC
    Inventor: Linette Bond
  • Publication number: 20140287395
    Abstract: A method for medical skills training is provided that includes simulating a current condition of at least one simulated patient wherein the current condition comprises dynamic physiology, appearance, and behavior of the patient using one or more physiology models; outputting the simulated patient in the current condition on a visual display; receiving input from one or more users, wherein the input represents one or more medical interactions to be virtually applied to the simulated patient; processing the inputs using the physiology model in conjunction with one or more physiological variables that change over time based on the physiology model, in response to corresponding deterioration clocks and the inputs; and outputting one or more changes to the current condition of the simulated patient by applying different animations to the simulated patient based on the processed inputs. As system and computer readable media for medical skills training are also provided.
    Type: Application
    Filed: March 19, 2014
    Publication date: September 25, 2014
    Applicant: VCOM3D, INC.
    Inventors: Daniel Stephen Silverglate, Tu Thanh Lam, Edward Mitford Sims
  • Publication number: 20140287396
    Abstract: An application for a method and system providing educational seekers a search tool that finds education opportunities across a large number of educational/training providers. The search tool finds courses and/or programs of interest such as certifications, vocational programs, two-year programs, four-year programs, MBA programs, certain financial aide features, specific course offerings, specific sports programs, placement success, etc, The system includes educational software robots called edu bots that visit educational program hosting web sites of the various educational/training providers, extracting information regarding the programs, courses, faculty, financial assistance, sports programs, location, extra-curricular activities, etc. The information is then stored in a common, searchable database for later searching by the educational seeker.
    Type: Application
    Filed: April 13, 2011
    Publication date: September 25, 2014
    Applicant: GEOGRAPHIC SOLUTIONS, INC.
    Inventors: Bill Megargel, Levi Richards, Paul Toomey
  • Publication number: 20140287397
    Abstract: A computer-implemented method according to various aspects of the present disclosure includes: retrieving, by a computer system, a lesson module from a database; receiving, by the computer system, information regarding a student; modifying the lesson module, by the computer system, based on the information regarding the student; and providing the lesson module to the student.
    Type: Application
    Filed: February 13, 2014
    Publication date: September 25, 2014
    Applicant: NEURON FUEL, INC.
    Inventors: Kelvin Voon-Kit Chong, Srinivas A. Mandyam, Vidya S. Mandyam, Krishna Vedati
  • Publication number: 20140287398
    Abstract: A system and method for assessing the co-scholastic skills of users have been disclosed. The system envisaged by the present disclosure envisages screening speechless short films to individuals in order to assess their strengths and weaknesses in co scholastic areas such as attitude towards life, moral values, critical thinking skills, creative thinking skills, decision making skills, analytical skills; problem solving skills, communication skills and emotional sensitivity. The system exploits various ideas, concepts and messages imparted by the short speechless movies to enhance the co-scholastic skills of individuals. The user is required to view the short speechless film displayed on a user interface. Subsequent to viewing the short speechless film, the user is required to answer an assessment test, preferably online assessment test. Based on the answers of users to the displayed assessment questions, the user's competency in co-scholastic skills is determined by an assessment processor.
    Type: Application
    Filed: June 5, 2014
    Publication date: September 25, 2014
    Inventor: Gautam Singh
  • Publication number: 20140287399
    Abstract: The technique relates to a system and method for learning and learning oriented assessment of at least one learner based on a role to be performed by the at least one learner. This technique involves identifying knowledge areas related to a particular role to be performed by the learner. Under each knowledge area different learning workflows are identified and relevant topics are mapped to the learning workflows. The performance expectation from the learner at each learning workflow level is defined. The one more challenges related to the mapped topics are created and presented to the learner to solve and a score is generated for solving the challenges. This score is compared with the predefined performance expectation to determine the learning effectiveness of the learner and a capability index is computed for the learner.
    Type: Application
    Filed: February 13, 2014
    Publication date: September 25, 2014
    Applicant: Infosys Limited
    Inventors: Subraya Beleyur Manjappa, Manjunatha Prasanna Sathyanarayana, Meenakshi Sahasranaman, Rengarajan Ramanujam, Amit Purohit, Anooja Mary Jacob
  • Publication number: 20140287400
    Abstract: A system including an object-oriented programming language for building state-based applications with flow control, event loops, measures of similarity, and Boolean logic to dynamically control the interaction between members in a social network around content and, in particular, project-based activities, where the system collects and groups individuals who are members of a social network, projects or assignments and their content, and activities or processes within projects based on the attributes of the objects and runtime events to create a social context for learning or for other interaction.
    Type: Application
    Filed: June 4, 2014
    Publication date: September 25, 2014
    Inventors: Linda T. Dozier, Edmund J. Fish, Nina Zolt, Miles R. Gilburne
  • Publication number: 20140287401
    Abstract: The present disclosure is directed to model figures of beings or objects, such as animate and inanimate objects. Animate objects include living beings, such as humans, animals, plants. Such models may comprise a wire frame formed of body segments movably connected with three-way, two-way and one-way joints. The frame may be wrapped with an additional wire. The joints may also include multi-axial joints.
    Type: Application
    Filed: October 31, 2012
    Publication date: September 25, 2014
    Inventors: Christopher T. Hardy, Keying Zhang
  • Publication number: 20140287402
    Abstract: The invention relates to high throughput screening methods for identifying, isolating and retrieving cells secreting antibodies of interest, e.g., having functional activity and/or multi-antigen specificities. It further provides methods for the cloning of said antibodies VH/VL sequences and the generation of recombinant monoclonal antibodies derived thereof having the features of interest.
    Type: Application
    Filed: June 27, 2012
    Publication date: September 25, 2014
    Applicant: VALNEVA
    Inventors: Pierre Garrone, Riad Abès, Nicola Beltraminelli, Majid Mehtali
  • Publication number: 20140287403
    Abstract: Motion detector comprising a flexible support (1,5) adapted to hold at least one object (6-9), a sensor (4) for measuring the displacement of said support (1) and processing means for differentiating the fluctuations of said support (1) from those induced by said object (6-9).
    Type: Application
    Filed: October 12, 2012
    Publication date: September 25, 2014
    Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Sandor Kasas, Giovanni Longo, Giovanni Dietler, Livan Bladimir Alonso Sarduy
  • Publication number: 20140287404
    Abstract: The invention is to improved compositions and methods for the detection of target bisulfite converted methylated nucleotide sequences.
    Type: Application
    Filed: February 21, 2014
    Publication date: September 25, 2014
    Inventors: Shihai X. Huang, Edward N. Granados
  • Publication number: 20140287405
    Abstract: Provided is a method of detecting or quantifying a wheat species-specific DNA in a test sample by polymerase chain reaction. The method comprises a step of amplifying a nucleic acid molecule having a partial sequence of a nucleotide sequence identified as SEQ ID NO: 1 using a nucleic acid molecule in the test sample or a nucleic acid molecule extracted from the test sample as the template and using a primer pair capable of amplifying the partial sequence and a step of detecting or quantifying the amplified nucleic acid molecule.
    Type: Application
    Filed: February 25, 2014
    Publication date: September 25, 2014
    Applicant: Nisshin Seifun Group Inc.
    Inventors: Kazumi KITTA, Satoshi FURUI, Junichi MANO, Shinjiro IMAI, Keiko TANAKA, Yasuyuki MATSUOKA, Shinichiro ARAMI, Megumi SATO, Hiroyuki HARAGUCHI, Youichi KURIMOTO
  • Publication number: 20140287406
    Abstract: The present invention provides a corn plant designated MON88017 and DNA compositions contained therein. Also provided are assays for detecting the presence of the corn plant MON88017 based on a DNA sequence and the use of this DNA sequence as a molecular marker in a DNA detection method.
    Type: Application
    Filed: February 26, 2014
    Publication date: September 25, 2014
    Applicant: Monsanto Technology LLC
    Inventors: Kim A. Beazley, Timothy R. Coombe, Mark E. Groth, Terri B. Hinchey, Jay C. Pershing, Ty T. Vaughn, Bei Zhang
  • Publication number: 20140287407
    Abstract: This disclosure concerns a system and method for detecting heterologous DNA in plant materials.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 25, 2014
    Applicant: DOW AGROSCIENCES LLC
    Inventors: John P. Davies, Warren S. Lee, Vaka S. Reddy, Xing Liang Liu, Satyalinga S. Gampala
  • Publication number: 20140287408
    Abstract: The present invention provides methods, systems, kits, and compositions for magnetically purifying target nucleic acid sequences from a sample using bait molecules configured to bind both target nucleic acid sequences and magnetic binding particles. In certain embodiments, the bait molecules comprise a short target capture sequence (e.g., 18 to 48 bases), and the methods employ a short hybridization time (e.g., 1-4 hours) and a low hybridization temperature (e.g., about room temperature).
    Type: Application
    Filed: March 13, 2014
    Publication date: September 25, 2014
    Applicant: Abbott Molecular Inc.
    Inventors: Hong Su, Shihai Huang
  • Publication number: 20140287409
    Abstract: Compositions and methods related to assessing the risk of cancer, such as breast cancer, lung cancer and bladder cancer, through analyzing the length of telomeres, such as chromosome 9p, 15p, and/or Xp telomere, such as the short arm of the 9p, 15p, and/or Xp telomere.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicant: Georgetown University
    Inventor: Yun-Ling Zheng
  • Publication number: 20140287410
    Abstract: Probe systems and methods are provided for detecting nucleic acid targets using labeled polynucleotide probes and antiprobes that interact together and with complementary targets. These interactions result in signaling changes that indicate target frequency and provide error-checking functions that facilitate single base discrimination. These probe:antiprobe compositions enable real-time PCR detection, end-point detection and microarray detection of microbial species, drug resistant mutants, and cancer related variants. The probe:antiprobe may be an internal probe between two primers or may be a primer-probe. The probe also may be modified by introducing a base mismatch to increase thermodynamic discrimination of a correct versus incorrect target differing by a single base. Probe systems also are provided for use in methods of increasing target amplification and detecting specific single base variants.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Inventor: David A. Shafer
  • Publication number: 20140287411
    Abstract: Provided are compositions, kits, and methods for the identification of Listeria. In certain aspects and embodiments, the compositions, kits, and methods may provide improvements in relation to specificity, sensitivity, and speed of detection.
    Type: Application
    Filed: May 2, 2014
    Publication date: September 25, 2014
    Inventors: Michael R. RESHATOFF, Kristin W. LIVEZEY, James J. HOGAN
  • Publication number: 20140287412
    Abstract: The present invention provides a method for detecting ACF by analyzing a test region of large intestine tissue at the molecular level. Namely, the present invention relates to a method for detecting aberrant crypt foci (ACF) that comprises detecting an ACF detection marker in a test region of large intestine tissue, by using one or more types of molecules for which ACF-specific expression increases as the ACF detection marker, the molecule being selected from the group consisting of SLC2a1, and SLC7a7; an ACF detection marker for detecting the ACF in human-derived large intestine tissue, that is SLC2a1, or SLC7a7; and, a method for evaluating risk of colorectal cancer and colorectal adenoma in subjects based on the results of detecting ACF in a test region of large intestine tissue of the subjects using the aforementioned ACF detection method.
    Type: Application
    Filed: June 6, 2014
    Publication date: September 25, 2014
    Applicants: OLYMPUS CORPORATION, THE UNIVERSITY OF TOKUSHIMA
    Inventors: Fumiko Ono, Yoko Horino, Tetsuji Takayama, Naoki Muguruma, Koichi Okamoto
  • Publication number: 20140287413
    Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.
    Type: Application
    Filed: June 9, 2014
    Publication date: September 25, 2014
    Applicants: Battelle Memorial Institute, Institute for Systems Biology
    Inventors: David Galas, Richard Evan Gelinas, Clay Braden Marsh, Melissa Garnet Piper, Kai Wang, Shile Zhang
  • Publication number: 20140287414
    Abstract: A DNA analysis system that controls DNA analysis by wireless using an application of a mobile device and a very small DNA analysis apparatus, and that receives a DNA analysis result in real time on the spot is provided. Therefore, by performing DNA analysis by simultaneously controlling a plurality of small DNA analysis apparatuses using signal processing and screen display functions of a mobile device, analysis speed of DNA is improved, and an analysis result of DNA can be provided in real time. Further, by forming a DNA analysis apparatus in a very small size, DNA can be immediately analyzed with low power consumption on the spot using a small sample, and the DNA analysis apparatus can be carried.
    Type: Application
    Filed: August 28, 2013
    Publication date: September 25, 2014
    Applicant: Electronics and Telecommunications Research Institute
    Inventors: Kwang Hyo CHUNG, Jin Tae KIM, Doo Hyeb YOUN, Ki-Chul KIM, Young-Jun YU, Jin Sik CHOI, Choon Gi CHOI
  • Publication number: 20140287415
    Abstract: Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays.
    Type: Application
    Filed: December 20, 2013
    Publication date: September 25, 2014
    Applicant: ILLUMINA, INC.
    Inventors: Geoffrey Paul Smith, Roberto Rigatti, Tobias William Barr Ost, Shankar Balasubramanian, Raquel Maria Sanches-Kuiper
  • Publication number: 20140287416
    Abstract: A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided.
    Type: Application
    Filed: February 14, 2014
    Publication date: September 25, 2014
    Inventors: Michael HARROLD, Aldrich LAU, Ben JOHNSON, Gilbert AMPARO, Frank MERCER
  • Publication number: 20140287417
    Abstract: Improved methods of assessing status of a solid-tumor cancer in a subject involving detection of tumor-associated mutations in the subject's blood.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 25, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Peter Meldgaard, Boe Sorensen, Julie Tsai, Wei Wen, Lin Wu
  • Publication number: 20140287418
    Abstract: The invention relates to a concentrated and buffered liquid composition for amplifying nucleic acids, comprising at least one dNTP, at least one enzyme required for the amplification, at least one oligonucleotide primer, and at least one fluorescent nucleotide probe, in the presence of a polyol and/or of polyvinylpyrrolidone (PVP).
    Type: Application
    Filed: March 13, 2014
    Publication date: September 25, 2014
    Applicant: Bio-Rad Innovations
    Inventors: Chantal SAVOYE, Patrice SARFATI
  • Publication number: 20140287419
    Abstract: Compositions and methods comprising polynucleotides and polypeptides having dicamba decarboxylase activity are provided. Further provided are nucleic acid constructs, host cells, plants, plant cells, explants, seeds and grain having the dicamba decarboxylase sequences. Various methods of employing the dicamba decarboxylase sequences are provided. Such methods include, for example, methods for decarboxylating an auxin-analog, method for producing an auxin-analog tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein. Methods are also provided to identify additional dicamba decarboxylase variants.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Inventors: Eric Althoff, Yih-En Andrew Ban, Linda A. Castle, Daniela Grabs, Jian Lu, Phillip A. Patten, Yumin Tao, Alexandre Zanghellini
  • Publication number: 20140287420
    Abstract: The present invention relates to a method and system for Polymerase Chain Reaction (“PCR”), High Resolution Melt (“HRM”) analysis and microfluidics, and, more specifically, to a method and system for implementing the processes of PCR and HRM on a microscale in a microfluidics chamber for certain purposes including for purposes of DNA detection and/or extraction.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Applicant: Syracuse University
    Inventor: Molly M. Cadle-Davidson
  • Publication number: 20140287421
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Application
    Filed: April 21, 2014
    Publication date: September 25, 2014
    Applicant: Genomic Health, Inc.
    Inventors: Melody A. Cobleigh, Steven Shak, Joffre B. Baker, Maureen T. Cronin
  • Publication number: 20140287422
    Abstract: The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased lung. The present invention also identifies and quantifies expression profiles which serve as useful diagnostic markers as well as markers that are useful to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.
    Type: Application
    Filed: April 30, 2014
    Publication date: September 25, 2014
    Applicant: UNIVERSITY OF TOLEDO
    Inventors: Jeffrey P. Demuth, Erin L. Crawford, James C. Willey, David A. Weaver, Kristy A. Warner, Timothy G. Graves