Abstract: In one aspect, the present invention provides a device for occluding an aperture in a body, for example, a patent foramen ovale (PFO), including a first side adapted to be disposed on one side of the septum and a second side adapted to be disposed on the opposite side of the septum. The device has an elongated, low-profile delivery configuration and a shortened, radially expanded deployment configuration. The first and second sides are adapted to occlude the aperture upon deployment of the device at its intended delivery location. The device also includes a radially expandable center portion. In some embodiments, the center portion includes a plurality of ribs provided by slits in device. The ribs expand radially when the device is deployed. The expandable center portion facilitates the positioning of the device in the aperture. The device can be secured in the deployed configuration using a catch system.

Abstract: Multilayer structures including a porous layer and a non-porous layer are useful as buttresses when associated with a surgical stapling apparatus.

Abstract: A tissue approximation device comprising two elongate arms, an attachment means to secure the elongate arms to each other, adhesive pads on at least a portion of the elongate arms to anchor the tissue approximation device to the skin, and a locking means to lock the elongate arms in place relative to each other.

Abstract: A reconstruction system and method for fixation of bone to bone, or soft tissue to bone. The reconstruction system comprises two fixation devices (for example, two buttons) joined by a continuous loop of flexible material. Each button is provided with at least one opening that allows the passage of the flexible material. The button may be formed, for example, of metal, PEEK or PLLA. The flexible material may be FIBERWIRE® suture.

Abstract: A method and device for knotless fixation of tissue. A swivel anchor having a rotatable forked anchor tip is used to capture suture, such as a suture chain, for surgical tissue repair without requiring suture knots. Tension on the repair constructs is adjustable through the selection of the specific chain link or links of the suture chain captured by the forked anchor tip of the swivel anchor. The swivel anchor is secured in a hole in bone by advancing a fixation device, such as a cannulated interference screw, over the body of the anchor.

Abstract: A surgical apparatus includes an implant for mutually supporting an upper spinous process of a first vertebral body and a lower spinous process of a second vertebral body. The implant comprises a first implant component and a second implant component movable relative thereto along a clamping direction to transfer the implant out of a basic position in a spreading direction that is oriented transversely relative to the clamping direction into a spread position. The implant includes at least one introduction-side upper supporting element and at least one introduction-side lower supporting element that for laterally supporting the upper spinous process or the lower spinous process on the introduction-side. A fixing device for the implant is used for spreading the at least one introduction-side upper supporting element and the at least one introduction-side lower supporting element relative to each other along the spreading direction in an introduction position of the implant.

Abstract: The present invention provides spinous process implants and associated methods. In one aspect of the invention, the implant includes at least one extension with a first part and a second part where at least one arm is coupled to each of the first part and the second part. The first part and the second part are movable from a compact to a distracted state. In another aspect, the present invention provides a second extension that is slidingly coupled to the first and second arms. The second extension further comprises a third part and a fourth part that move with the first and second part.

Abstract: A spinal rod connector assembly for use with a vertebral bone screw has an articulating clamp for 1) fixing an orientation of the spinal rod connector assembly relative to and on the vertebral bone screw, and 2) attaching a separate spinal rod onto the spinal rod connector assembly in concert with one another. The articulating clamp resides in a body of the spinal rod connector assembly and transfers a received downward force laterally to a spinal rod component of the spinal rod connector assembly which is configured to abut the spinal rod and hold the spinal rod between itself and a spinal rod holder of the spinal rod connector assembly. The articulating clamp thus improves the force transfer efficacy of the system.

Abstract: A method of supporting a defect in the tissue of a living being includes the steps of: a) providing a delivery instrument that includes an elongated instrument, at least one barrier element, and a plurality of connecting members; b) inserting the elongated instrument into the tissue at or near the defect; c) deploying the barrier element from the delivery instrument into tissue at or near the defect, the barrier element having at least one connecting member attached thereto; d) extending at least one passage means from the delivery instrument; e) engaging at least a portion of the at least one connecting member with the at least one passage means, whereby the at least one passage means causes the at least one connecting member to pass through the tissue, and f) withdrawing the elongated instrument from the tissue, thereby deploying and securing the barrier element to support the tissue.

Abstract: The invention relates to bone compression devices and bone compression systems, and in particular, to bone compression devices and systems for use in connection with vertebrae. The bone compression devices and bone compression systems are disposed, or installed, along at least one bone to maintain the at least one bone in a desired spatial relationship. Broadly, the invention is directed to a bone compression device for placing in communication with at least one bone having a bone radius of curvature, the bone compression device comprising a plate having a pre-formed shape, a deformed shape, and at least one elastic shape therebetween, the pre-formed shape having a pre-formed radius of curvature less than the bone radius of curvature, the deformed shape having a deformed radius of curvature greater than the bone radius of curvature, and at least one of the at least one elastic shapes having an elastic radius of curvature that substantially corresponds to the bone radius of curvature.

Abstract: Spine stabilization devices, systems and methods are provided in which a single resilient member or spring is disposed on an elongate element that spans two attachment members attached to different spinal vertebrae. The elongate element passes through at least one of the two attachment members, permitting relative motion therebetween, and terminates in a stop or abutment. A second resilient member is disposed on the elongate element on an opposite side of the sliding attachment member, e.g., in an overhanging orientation. The two resilient members are capable of applying mutually opposing urging forces, and a compressive preload can be applied to one or both of the resilient members.

Abstract: A bone plate for the stabilization of bones includes upper and lower surfaces extending along a central longitudinal axis. The lower surface is configured to contact a target portion of bone when in an operative configuration a through opening extending through the plate from the upper surface to the lower surface. The through opening is sized and shaped to receive a stabilization plate. The through opening has an elongated curved shape selected to conform to a cross-sectional shape of a proximal portion of the stabilization plate.

Abstract: Bone plates and methods of using the bone plates for adjoining bone fragments are disclosed herein. A device for adjoining at least two bone fragments includes a delivery catheter having an elongated shaft with a proximal end, a distal end, and a longitudinal axis therebetween, wherein the delivery catheter has an inner void for passage of at least one filling material and an inner lumen for passage of a light source; a conformable bone plate releasably engaging the distal end of the delivery catheter, wherein the conformable bone plate has a first surface, a second surface, a proximal end, and a distal end and at least one aperture extending from the first surface to the second surface for receiving a fastener; and an adapter releasably engaging the proximal end of the delivery catheter for receiving the light source and a delivery system housing the at least one filling material.

Abstract: An orthopedic plate has a first end including a locking screw hole that receives a locking screw and spaced from that hole is a compression housing that extends from the bone-facing side of the plate and which receives a compression screw that forms an angle of from about 10° to about 70° with a longitudinal axis of the plate. In a further embodiment, the plate also includes a second end with a chamfer for insertion of the plate into bone, and in a still further embodiment, the plate is an MTP plate.

Abstract: A spinal plate having an upper surface and a lower surface, the lower surface adapted to contact bone. A plurality of holes extend from the upper surface to the lower surface through the plate which is configured and adapted to receive bone fasteners for fixing the spinal plate to bone. At least one set screw receiving hole adjacent from each one of the plurality of holes, the set screw receiving hole configured to adapt with a set screw. The lower surface of the spinal plate comprises a ridge that protrudes from the underside of the plate and encloses the plurality of holes spaced inward from the perimeter of the spinal plate.

Abstract: A kind of bone plate gimbal lock pressure device. The body of the bone plate (1) has a microscler slippery hole (2), in which there has a locking slider (3); on the slider (3) there is a cone-shaped screw hole (3-3) with a cone-head screw (4) inside. The shapes at two inside sides of the microscler slippery hole (2) cross section are internal arc-shaped, and the shapes of the two sides of the locking slider (3) are correspondingly external arc (3-1); in the middle of the locking slider (3) there is a notch (3-2). The locking slider (3) can slide in the microscler slippery hole (2) to meet the pressure requirement, and also can sway from side to side to adjust the direction of the cone-head screw (4) according to the requirement. The two sides of the locking slider (3) are arc; after tightening the screw (4), the arc contact will make the locking slider (3) not take off.

Abstract: In an exemplary embodiment, the present invention provides a fastener assembly that can be used for the fixation or anchoring of orthopedic devices or instruments to bone tissue. In particular, the present invention preferably provides a low profile variable angle or fixed angle fastener assembly that is able to securely connect the orthopedic device to bone tissue. Furthermore, in an exemplary embodiment, the present invention provides a fastener assembly having a locking mechanism that will quickly and easily lock the fastener assembly with respect to the orthopedic device.

Abstract: A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body including: a rod receiving portion with a channel for receiving a rod, and a head receiving portion for accommodating a head of a bone anchoring element, the head receiving portion having an open end and being flexible for inserting and clamping of the head, and an exterior surface with a curved portion; and a locking ring around the head receiving portion, wherein the locking ring has an interior surface with a curved portion for engagement with the curved portion of the exterior surface of the head receiving portion for locking a position of the head relative to the head receiving portion.

Abstract: A receiver body for an elongated spinal fixation element includes a housing portion with one or more flanges extending outwardly. In one embodiment, the receiver body includes first and second flanges extending outwardly from the housing portion. The housing portion includes first and second slots that form a passage through the housing portion. Each flange has a circular perimeter edge and a chamfered section, the chamfered section having a notched undercut for engagement with an instrument. In another embodiment, the receiver body includes a housing portion having a circular flange with a first chamfered section and a second chamfered section diametrically opposite the first chamfered section. The first chamfered section has a first aperture that opens out beneath the flange, and the second chamfered section has a second aperture that opens out beneath the flange. The first and second apertures form diametrically opposed pivot-attachment points for an instrument.

Abstract: A therapeutic laser with a source of pulsed electromagnetic radiation, a control device for controlling the intensity and/or the duration of the therapeutic laser applied to the tissue, and a detection device for detecting optoacoustic signals triggered by irradiating the living tissue with the pulsed electromagnetic radiation. The therapeutic laser is characterized by an evaluation device that acts on the control device and is used for calculating a degree of quality B(t) from the optoacoustic signals detected by the detection device for individual laser pulses applied to a predetermined laser spot and determining a fit function f(t) at a predetermined point in time ?t1, the fit function f(t) approximating the mean curve of B(t) for 0?t??t1. The intensity and/or the irradiation time of the therapeutic laser is defined by the parameters for the predetermined laser spot, the parameters being determined for the fit function f(t).

Abstract: A device for providing radiation-based dermatological treatments includes a device body configured to be handheld by a user; a VCSEL laser supported in the device body, the VCSEL laser including multiple spaced-apart VCSEL beam sources configured to generate multiple discrete laser beams for generating multiple discrete treatment spots on the skin; an application end configured to be manually moved across the surface of the skin during a treatment session; and electronics configured to control the multiple VCSEL beam sources to emit the multiple discrete laser beams toward the skin to provide a dermatological treatment.

Abstract: Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.

Abstract: A stent made of a material having a low strength and having a main body circumscribing a cylindrical shape and radially expandable from a contracted starting position into a dilated support position, comprising a) a plurality of support segments disposed around the circumference and arrayed on one another in the axial direction each segment being formed by a strut meandering in its coarse structure in its contracted starting position and having alternately opposing meandering curves expandable into the support position made of flexible material; b) a plurality of axial connectors connecting between zenith points of at least a part of the meandering curves in the axial-parallel direction of the support segments; (c) a plurality of x-ray marker projections, and d) at least one stabilizer for stabilizing the strut coarse structure in its contracted starting position against radial expansion and being automatically detachable upon radial expansion.

Abstract: A vascular method is disclosed comprising introducing a first flexible wire into a blood vessel, wherein the blood vessel has a first vessel end and a second vessel end and wherein the first flexible wire has a first end and a second end, sliding an angiotip along the first flexible wire in a direction away from the first end of the wire and toward the second end of the wire, frictionally engaging the first flexible wire with the angiotip, and pulling the first flexible wire through the blood vessel in the direction of the second vessel end, wherein the pulling of the first flexible wire pulls the angiotip through the blood vessel in the direction of the second vessel end.

Abstract: An endovascular delivery system includes an endovascular prosthetic device and a signal active guide wire engaging the endovascular prosthetic device. A rotary encoder is coupled with the guide wire and the endovascular prosthetic device to provide an encoder signal on the guide wire. The encoder signal is indicative of axial angular position of the endovascular prosthetic device during implantation of the endovascular prosthetic device in a body of a patient.

Abstract: A thoracic arch stent graft (1) has a tubular body of a biocompatible graft material (3) and at least one fenestration (13, 15) in the wall on one side thereof. A combination guide and tubular side arm assembly (20, 22) is mounted into the or each fenestration. The combination guide and tubular side arm assembly comprises a tubular portion (24) and a funnel portion (26) extending from a distal end of the tubular portion. The funnel portion has an angled open end. The tubular portion and the funnel portion are formed from a biocompatible graft material wall and have a lightweight space frame (38 40) formed from a resilient wire and supporting the graft material and defining the combination guide and tubular side arm assembly.

Abstract: Bioabsorbable self-expanding medical devices formed of an integral framework with a multiplicity of fenestrations are provided. The framework is continuous, non-filamentous, non-braided, and non-interlaced. The devices includes a non-blended hydrolysable co-polymeric material comprising an amorphous component with a glass transition temperature that is below ambient body temperature and a crystallizable component that possesses a crystalline melting point in excess of ambient body temperature. The devices radially expand from a compressed first diameter to an uncompressed second diameter equal to or greater than 1.5 times the first diameter within two minutes in an aqueous medium at 37° C. following release of a compressive force placed on the devices. Additionally, the medical device does not change axial length significantly as the radial dimensions of the devices are changed.

Abstract: A method includes covering ostai of branch vessels emanating from a main vessel and an aneurysm with a high metal to vessel ratio stent. A metal to vessel ratio of the high metal to vessel ratio stent is sufficiently high to encourage tissue ingrowth around the high metal to vessel ratio stent yet is sufficiently low to ensure perfusion of the branch vessels through the high metal to vessel ratio stent. The ingrowth of tissue provides secure fixation and sealing of the high metal to vessel ratio stent to the main vessel and remodels and essentially eliminates the aneurysm. Further, as the entire high metal to vessel ratio stent is permeably, the high metal to vessel ratio stent is deployed without having to rotationally position the high metal to vessel ratio stent.

Abstract: A fenestrated stent graft (1) with a tubular side arm (11) extending therefrom in which the side arm can be turned inside out to extend into the stent graft during deployment of the stent graft and extended out during deployment. Also disclosed is a deployment device (19) for such a side arm stent graft which has a deployment catheter (26) and a side arm guide (32), the side arm guide is releasably fastened at a proximal end to the branch tube (11) and is able to be moved independently of the deployment catheter such that the branch tube can be extended from the tubular body of the stent graft while it is fastened onto the side arm guide. The side arm guide can be formed from a side arm catheter (32) and a side arm guide wire (34) carried in the side arm catheter.

Abstract: An endoluminal support structure includes strut members interconnected by pivot joints to form a series of linked scissor mechanisms. The structure can be remotely actuated to compress or expand its shape by adjusting the scissor joints within a range of motion. In particular, the support structure can be repositioned within the body lumen or retrieved from the lumen. The support structure can be employed to introduce and support a prosthetic valve within a body lumen.

Abstract: Methods and devices for assessing the operation of a replacement heart valve. The method includes endovascularly delivering a replacement heart valve to a vicinity of a heart valve in an unexpanded configuration, and assessing the operation of the replacement heart valve in the vicinity of the heart valve before fully expanding the replacement heart valve. Methods and devices for assessing the location of a replacement heart valve. The method includes endovascularly delivering a replacement heart valve to a vicinity of the heart valve in an unexpanded configuration, expanding the replacement heart valve to a partially deployed configuration, and assessing the location of the replacement heart valve in the vicinity of the heart valve before fully expanding the replacement heart valve.

Abstract: A method for treating a body conduit/lumen having an undesired reduced diameter includes determining a target diameter of the conduit/lumen in a target location of the conduit/lumen, and delivering a self-expanding metal stent in a contracted configuration to the target location. In a fully expanded configuration, the stent has a diameter that is more than 50% larger than the target diameter over an entire length of the self-expanding stent.

Abstract: This document provides methods and materials that can be used to replace a circumferential segment of an esophagus. For example, methods and materials that can be used to provide a tubular connection from one stump end of an esophagus to another stump end of the esophagus are provided.

Abstract: Stents and methods of fabricating stents with prohealing layers and drug-polymer layers are disclosed.

Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.

Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self- or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self- or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.

Abstract: An apparatus and method for mitigating prolapsed are disclosed. The apparatus includes a contact member and an elongated rod that can be used to hold the contact member in position for coapting with a patient's native leaflets. A similarly configured sizing apparatus can also be used to facilitate implantation.

Abstract: A system designed to store an implant together with the tools necessary to implant the stored implant, and a method of using such system. Such system includes an implant storage tool adapted to retain the implant within a storage container. The implant storage tool is operable to provide an implant applicator.

Abstract: Intraocular implants and methods of making intraocular implants are provided. The intraocular implants can improve the vision of a patient, such as by increasing the depth of focus of an eye of a patient. In particular, the intraocular implants can include a mask having an annular portion with a relatively low visible light transmission surrounding a relatively high transmission central portion such as a clear lens or aperture. This construct is adapted to provide an annular mask with a small aperture for light to pass through to the retina to increase depth of focus. The intraocular implant may have an optical power for refractive correction. The intraocular implant may be implanted in any location along the optical pathway in the eye, e.g., as an implant in the anterior or posterior chamber.

Abstract: The invention relates to a intraocular lens system having a flexible anterior lens accommodation material behind the lens. The accommodation material may comprise of one or more macromers, which, when polymerized, adjust the properties of the accommodation material. The anterior lens is flexible such that the curvature of the lens changes during accommodation. The anterior lens may be used alone or in combination with a posterior lens.

Abstract: An accommodating intraocular lens has an anterior portion including an anterior viewing element and an anterior biasing element connected to the anterior viewing element. A posterior portion has a posterior viewing element and a posterior biasing element connected to the posterior viewing element. The anterior and posterior biasing elements are connected at first and second apices. First and second distending members are connected to the posterior portion. The first and second distending members extend to locations significantly anterior of an anterior side of the posterior viewing element.

Abstract: A method of dilating an infundibular space within the human head includes directing at least a distal portion of an elongate member of a medical device into a nasal cavity of the human head, the distal portion including a piercing tip and an expandable portion. The piercing tip is directed through tissue of an uncinate process or tissue near an uncinate process and into an ethmoid infundibulum and the expandable portion of the distal end is expanded within the ethmoid infundibulum.

Abstract: Medical delivery devices include a needle and a flexible compressible impermeable tube attached to the needle. The compressible tube has an open interior channel. The device is adapted to releasably hold a length of a medical implant in the open interior channel of the tube. The medical implant can be slidably inserted into the interior channel of the tube and is loosely held by the tube.

Abstract: The present invention involves tissue engineering constructs made from a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and bioceramic particles exposed on its surface using a gas foaming particle leaching (GF/PL) method and infused with collagen. Methods and apparatus for of forming scaffolds are also disclosed.

Abstract: A method for trochanteric reattachment can include positioning a femoral prosthesis relative to a proximal portion of a femur. A first portion of a self-locking adjustable flexible member construct can be coupled to a first attachment region of the prosthesis, and a second portion of the self-locking adjustable flexible member construct can be coupled to a second attachment region of the femoral prosthesis, where the second portion can be opposite the first portion. A trochanter can be positioned relative to the femur and a trochanteric engaging region of the prosthesis, and the self-locking adjustable flexible member construct can be positioned around an outer surface of the trochanter. Free ends of the self-locking adjustable flexible member construct can be tensioned to draw the trochanter into secure engagement with the prosthesis and the femur via the self-locking adjustable flexible member construct in an absence of a knot.

Abstract: Methods and systems are disclosed for accessing and treating the interior of the facet joint for vertebral distraction and immobilization. The systems include a number of tools that facilitate access to the facet joint, distraction of the articulating decortication of the articulating surfaces, and delivery of implants and agents into the facet joint for fusion.

Abstract: A nucleus pulposus replacement is described that includes a containment balloon that can sequester synthetic and/or tissue engineered fill material(s) in the nucleus pulposus region of the IVD thus mitigating migration and expulsion of the fill materials. The containment balloon can be formed of a biocompatible material that includes the structural proteins elastin and collagen. The containment balloon is joined to a closure device that can be used to deliver a fill material, e.g., a hydrogel, to the interior of the containment balloon following implantation of the replacement device in the intervertebral disc area.

Abstract: A multi-material spinal interbody device includes an inner dampener of compressible material in combination with a rigid outer material. The rigidity of the outer periphery of curved surfaces of the device, such as in an eluipsoid shape, provide support as a replacement to the nucleus propulsus, with the inner dampener providing for absorption of spinal forces.

Abstract: An implant having a base with a first contact surface and a hinged element, hingedly interconnected with a first portion of the base, providing a second contact surface. The first portion of the base is displaceable relative to a second portion so that the base can be shortened from an initial length towards a second length. A linking segment is hingedly connected to both the second portion of the base and to the hinged element so that shortening of the base causes the linking segment to push a region of the hinged element away from the base, thereby changing an angle of the second contact surface relative to the first contact surface.

Abstract: A vertebral spacer includes a body having a top side, a bottom side, a front side, and a rear side. The top side is configured to be positioned adjacent to a first vertebra and the bottom side is configured to be positioned against a second vertebra. First, second, third and fourth bores extend through the body. First and second compression fasteners disposable in the first and third bores, and first and second locking fasteners disposable in the second and fourth bores. The first compression fastener and the first locking fastener cooperate to apply and lock a first predetermined compression force between the body and the first vertebra. The second compression fastener and the second locking fastener cooperate to apply and lock a second predetermined compression force between the body and the second vertebra.