Patents Issued in January 14, 2016
  • STORAGE-STABLE COMPOSITIONS OF GLYCEROL MONOALKYL ETHERS
    Publication number: 20160008470
    Abstract: The present invention relates to compositions which comprise a combination a) of one or more glycerol monoalkyl ether(s) of the general formula R—O—CH2—CHOH—CH2OH in which R is a branched or unbranched C3-C18-alkyl group, where the alkyl group can be substituted by one or more hydroxyl and/or C1-C4-alkoxy group(s) and/or the alkyl chain can be interrupted by up to four oxygen atoms, with b) an antioxidant or two or more antioxidants as stabilizer(s), the simultaneous presence of phosphocholines and phosphocholine derivatives being excluded.
    Type: Application
    Filed: September 23, 2015
    Publication date: January 14, 2016
    Inventors: Wolfgang BEILFUSS, Ralf GRADTKE
  • TRANSDERMAL FORMULATIONS
    Publication number: 20160008471
    Abstract: The present invention relates to a non-aqueous composition that comprises a permeation enhancer such as a terpene, for delivering an active ingredient transdermally. The composition comprises at least on one active ingredient, a terpene, and a solvent, such as a non-hydroxyl containing solvent, non-heterocyclic ester solvent and/or a tripropylene glycol alkyl ether. The composition can be used to deliver a range of actives, such as anthelmintics. The present invention provides a platform composition and can be used to deliver a wide variety of active ingredients and combinations thereof transdermally to mammals.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 14, 2016
    Inventors: Laurie Robert BATT, Su WIN, Keryn DAVIES, David Anthony GILL, James Robert FALCONER, Douglas Robert CLEVERLY, Zimei WU
  • METAL-ORGANIC FRAMEWORKS WITH EXCEPTIONALLY LARGE PORE APERATURES
    Publication number: 20160008472
    Abstract: The disclosure relates to metal organic frameworks or isoreticular metal organic frameworks, methods of production thereof, and methods of use thereof.
    Type: Application
    Filed: July 13, 2015
    Publication date: January 14, 2016
    Inventors: Omar M. Yaghi, Hiroyasu Furukawa, Hexiang Deng
  • IMMEDIATE RELEASE PHARMACEUTICAL FORMULATION OF 4-[3-(4-CYCLOPROPANECARBONYL-PIPERAZINE-1-CARBONYL)-4-FLUORO-BENZYL]-2H-PHTHALAZIN-1-ONE
    Publication number: 20160008473
    Abstract: The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one for increasing the bioavailability of the drug.
    Type: Application
    Filed: April 16, 2015
    Publication date: January 14, 2016
    Applicant: ASTRAZENECA UK LIMITED
    Inventors: Michael Karl Bechtold, Julie Kay Cahill, Katja Maren Fastnacht, Kieran James Lennon, Bernd Harald Liepold, Claudia Bettina Packhaeuser, Benedikt Steitz
  • PHARMACEUTICAL FORMULATION CONTAINING GLYCOSAMINOGLYCAN
    Publication number: 20160008474
    Abstract: A pharmaceutical formulation containing a glycosaminoglycan is provided. In this pharmaceutical formulation, a glycosaminoglycan layer surrounding a drug layer is used to improve the treatment efficiency of enteric diseases.
    Type: Application
    Filed: April 19, 2013
    Publication date: January 14, 2016
    Inventor: Pao-Ho CHANG
  • COACERVATE MICRO AND/OR NANO DROPLETS AND HYDROGELS
    Publication number: 20160008475
    Abstract: A composition includes a plurality of coacervate micro and/or nanodroplets of oxidized alginate and a methacrylated gelatin.
    Type: Application
    Filed: July 9, 2015
    Publication date: January 14, 2016
    Inventors: Eben Alsberg, Oju Jeon, David Wolfson
  • STABILIZED PEDIATRIC SUSPENSION OF CARISBAMATE
    Publication number: 20160008476
    Abstract: The present invention provides a stabilized pharmaceutical suspension of carisbamate for pediatric and adult use. More particularly, the suspension is stabilized with hypromellose (HPMC) to prevent crystal growth of the suspended particles and to prevent re-crystallization of the drug product with change in polymorphic form.
    Type: Application
    Filed: September 18, 2015
    Publication date: January 14, 2016
    Inventors: Roger EMBRECHTS, Cedric DE LEERSNIJDER
  • PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZOQUINOLIN(AMINES) AND DERIVATIVES THEREOF SUITABLE FOR LOCAL ADMINISTRATION
    Publication number: 20160008477
    Abstract: The present invention relates in general to the field of modulators of the innate immune system, particularly to pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof, preferably suitable for local administration, such as, intravesical administration. In addition, the present invention concerns the use of imidazoquinolin(amines) and derivatives thereof for intravesical treatment of bladder diseases, such as, for example, bladder cancer and cystitis. The present invention furthermore comprises methods of treatment for these diseases as well as methods of administration of the inventive pharmaceutical compositions.
    Type: Application
    Filed: June 26, 2015
    Publication date: January 14, 2016
    Inventors: Lorenzo LEONI, Roberto Maj, Franco Pattarino, Carlo Vecchio
  • Pharmaceutical Formulation Comprising NSAID And Cyclodextrin
    Publication number: 20160008478
    Abstract: A liquid throat spray composition for topical application to a sore throat including an aqueous solution of an NSAID and cyclodextrin.
    Type: Application
    Filed: September 21, 2015
    Publication date: January 14, 2016
    Inventors: Edward Beech, Alden Rodwell, Mark Squires
  • Formulation of Curcumin with Enhanced Bioavailability of Curcumin and method of preparation and treatment thereof
    Publication number: 20160008479
    Abstract: A medicinal composition useful for the treatment of head and neck cancer premalignant lesions. The composition includes a curcuminoid mixture and an essential oil of turmeric. The curcuminoid mixture consists of curcumin, demethoxycurcumin and bisdemethoxycurcumin. The essential oil of turmeric includes about 45% ar-turmerone. The weight ratio of curcuminoid mixture to essential oil of turmeric ranges from about 1:3 to about 99:1. Methods of preparation of the composition is provide. Methods of treatment of head and neck cancer premalignant lesions by oral administration is provided.
    Type: Application
    Filed: April 29, 2015
    Publication date: January 14, 2016
    Inventor: Benny Antony
  • FUSION PROTEIN COMPRISING TARGETING MOIETY, CLEAVAGE SITE, AND CELL MEMBRANE PENETRATING DOMAIN, AND USE THEREOF
    Publication number: 20160008480
    Abstract: A fusion protein including a targeting moiety, a cleavage site, and a cell membrane penetrating domain, a conjugate including the fusion protein and a bioactive molecule, and methods employing the fusion protein and the conjugate are provided.
    Type: Application
    Filed: July 8, 2015
    Publication date: January 14, 2016
    Inventors: Jae Il Lee, Soshin Ahn, Jung Min Kim, Jungmin Lee, Jung-Hoon Lee
  • SELF-ASSEMBLING COMPLEX FOR TARGETING CHEMICAL AGENTS TO CELLS
    Publication number: 20160008481
    Abstract: The present invention relates to a complex that can be injected into the body to hone in on target cells to deliver molecules. In one embodiment, the invention provides a drug delivery system that includes components that self-assemble into one targeted conjugate. In another embodiment, the invention includes a targeted carrier protein and a nucleic acid sequence non-covalently linked to one or more drugs.
    Type: Application
    Filed: July 10, 2015
    Publication date: January 14, 2016
    Inventor: Lali K. MEDINA-KAUWE
  • GLA DOMAINS AS TARGETING AGENTS
    Publication number: 20160008482
    Abstract: The disclosure relates to the recombinant Gla domain proteins and their use targeting phosphatidylserine (PtdS) moieties on the surface of cells, particularly those expressing elevated levels of PtdS, such as cells undergoing apoptosis. These proteins can be linked to both diagnostic and therapeutic payloads, thereby permitting identification and treatment of cells expression elevated PtdS.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 14, 2016
    Inventors: Maxine BAUZON, Terry HERMISTON
  • NOVEL INSULIN ANALOG AND USE THEREOF
    Publication number: 20160008483
    Abstract: The present invention relates to an insulin analog that has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin, a conjugate prepared by linking the insulin analog and a carrier, a long-acting formulation including the conjugate, and a method for preparing the conjugate.
    Type: Application
    Filed: February 26, 2014
    Publication date: January 14, 2016
    Applicant: HANMI PHARM. CO., LTD
    Inventors: Sang Youn HWANG, Yong Ho HUH, Jin Young KIM, Sung Hee HONG, In Young CHOI, Sung Youb JUNG, Se Chang KWON, Dae Jin KIM, Hyun Uk KIM, Myung Hyun JANG, Seung Su KIM
  • IMPROVED PREPARATION METHOD FOR HIGH-YIELD PRODUCTION OF PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE
    Publication number: 20160008484
    Abstract: Provided is a method for preparing a conjugate by linking a physiologically active polypeptide, a non-peptidyl polymer linker, and an immunoglobulin constant region via a covalent bond. The method for efficiently preparing the physiologically active polypeptide conjugate uses a salt in a coupling reaction to solve the problem of low production yield during preparation of the physiologically active polypeptide conjugate. The conjugate of physiologically active polypeptide-non-peptidyl polymer-immunoglobulin constant region can be produced with high purity and yield by the subject method. Due to the method for preparing the physiologically active polypeptide conjugate, production costs can be reduced. Therefore, the method can be used to develop long-acting formulations of physiologically active polypeptides, which have improved industrial applicability and drug regulation compliance.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 14, 2016
    Applicant: HANMI PHARM. CO., LTD.
    Inventors: Myung Hyun JANG, Min Young KIM, Dae Jin KIM, Sung Youb JUNG, Se Chang KWON
  • Engineered Antibody Constant Regions for Site-Specific Conjugation and Methods and Uses Therefor
    Publication number: 20160008485
    Abstract: The present invention is directed to antibodies, and antigen-binding portions thereof, engineered to introduce amino acids for site-specific conjugation. The invention relates to engineered antibody constant region (Fc, C?, C?, and C?) polypeptides, and portions thereof, and antibodies comprising the polypeptides. Further, the invention relates to Fc fusion proteins comprising an engineered Fc region. The invention also relates to methods and uses of the engineered antibodies and portions for, among other things, production of antibody-drug conjugate therapeutics.
    Type: Application
    Filed: December 19, 2012
    Publication date: January 14, 2016
    Inventors: Kimberly Marquette, Eric Bennett, Lioudmila Tchistiakova, L. Nathan Tumey, Jack Bikker, Valerie Calabro, Edmund Graziani
  • DUOCARMYCIN ADCS SHOWING IMPROVED IN VIVO ANTITUMOR ACTIVITY
    Publication number: 20160008486
    Abstract: The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumours and haematological malignancies expressing HER2, in particular breast cancer, gastric cancer, bladder cancer, ovarian cancer, lung cancer, prostate cancer, pancreatic cancer, colorectal cancer, head and neck squamous cell cancer or osteosarcoma, and acute lymphoblastic leukaemia. In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of human solid tumours with HER2 IHC 2+ or 1+ and HER2 FISH negative tissue status. Advantageously, the present invention relates to duocarmycin-containing ADCs for use in the treatment of triple negative breast cancer (TNBC).
    Type: Application
    Filed: September 18, 2015
    Publication date: January 14, 2016
    Applicant: Synthon Biopharmaceuticals B.V.
    Inventors: Willem DOKTER, Peter Johannes GOEDINGS, Gijsbertus Franciscus Maria VERHEIJDEN, Patrick Henry BEUSKER
  • DUOCARMYCIN ADCS FOR USE IN TREATMENT OF ENDOMETRIAL CANCER
    Publication number: 20160008487
    Abstract: The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumours expressing HER2, wherein the human solid tumour expressing HER2 is endometrial cancer, in particular uterine serous carcinoma (USC). In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of endometrial cancer, notably USC, with HER2 IHC 2? or 1+ and HER2 FISH negative tumour tissue status.
    Type: Application
    Filed: September 18, 2015
    Publication date: January 14, 2016
    Inventors: Alessandro Davide SANTIN, Peter Johannes GOEDINGS
  • Vectors And Methods For Genetic Immunization
    Publication number: 20160008488
    Abstract: Improved DNA vaccine plasmids are disclosed that contain novel immunostimulatory RNA compositions. The improved plasmids eliminate all extraneous sequences, incorporate a novel antibiotic free short RNA based selectable marker, increase eukaryotic expression using a novel chimeric promoter, improve yield and stability during bacterial production, and improve immunostimulation. These vectors are utilized in immunization to elicit improved immune responses or therapy to induce type 1 interferon production.
    Type: Application
    Filed: June 29, 2015
    Publication date: January 14, 2016
    Inventor: James A. Williams
  • METHODS FOR MODULATING NUCLEAR ACETYLTRANSFERASE ACTIVITY IN LIVING BRAIN, MEMORY ACCURACY AND FEAR GENERALIZATION
    Publication number: 20160008489
    Abstract: The disclosure provides methods for screening for a modifier or a modulator of a brain function or a cognitive function. The disclosure also provides methods for modifying or modulating a brain function or a cognitive function in an individual.
    Type: Application
    Filed: July 14, 2015
    Publication date: January 14, 2016
    Inventor: Edward KORZUS
  • METAL CHELATE COMPOUNDS FOR BINDING TO THE PLATELET SPECIFIC GLYCOPROTEIN IIB/IIIA
    Publication number: 20160008490
    Abstract: The present invention is directed to compounds that bind to glycoprotein IIb/IIIa and can be used for diagnostic imaging, in particular magnetic resonance imaging of thrombi. The disclosed compounds enable the binding to glycoprotein IIb/IIIa receptor combined with an adequate relaxivity.
    Type: Application
    Filed: February 11, 2014
    Publication date: January 14, 2016
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: MARKUS BERGER, JESSICA LOHRKE, GREGOR JOST, MICHAEL REINHARDT
  • METHOD FOR IMMUNE CELL TRACKING
    Publication number: 20160008491
    Abstract: A method of tracking immune cells to detect immune response. The method including steps of identifying a patient having a disease associated with an organ; administering biocompatible magnetic nanoparticles into the blood stream of the patient; and obtaining a magnetic resonance image of the organ. The presence of hyperintense or hypointense spots in the magnetic resonance image indicates immune response in the patient.
    Type: Application
    Filed: July 10, 2015
    Publication date: January 14, 2016
    Inventors: Chih-Lung Chen, Wen-Yuan Hsieh, Chen-Hsuan Lin, Shian-Jy Wang
  • COMPOSITIONS OF SACCHARIDE COATED NANOPARTICLES AND USES
    Publication number: 20160008492
    Abstract: This disclosure relates to nanoparticles of metals, alloys, metal oxides, and multi-metallic oxides comprising oligosaccharide coatings and uses such as in molecular imaging. Typically, the nanoparticles comprise iron oxide. In certain embodiments, the disclosure relates to compositions comprising iron oxide nanoparticles comprising a saccharide coating of less than 5 nm. In certain embodiments, the average core size is below 5 nm with highly uniform core size and a hydrodynamic size of not greater than 10 nm.
    Type: Application
    Filed: July 13, 2015
    Publication date: January 14, 2016
    Inventors: Hui Mao, Jing Huang
  • RADIOACTIVE SUBSTRATES FOR ALDEHYDE DEHYDROGENASE
    Publication number: 20160008493
    Abstract: A detectable substrate for aldehyde dehydrogenase (ALDH) can include a radiolabel. When acted upon by ALDH in an ALDH-expressing cell, e.g., cancer cells, the radiolabeled substrate accumulates in the ALDH-expressing cell. ALDH-expressing cells can be distinguished by the accumulated radioactivity. When combined with suitable imaging technique, the detectable substrate can be used for in vivo imaging of cancer cells.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 14, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN C. POMPER, HAOFAN WANG, IL MINN, RONNIE C. MEASE
  • TAU IMAGING PROBE
    Publication number: 20160008494
    Abstract: An object of the present invention is to provide a probe for imaging a ?-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: September 22, 2015
    Publication date: January 14, 2016
    Inventors: Yukitsuka KUDO, Shozo FURUMOTO, Nobuyuki OKAMURA
  • Metallocene Compounds and Labeled Molecules Comprising the Same for In Vivo Imaging
    Publication number: 20160008495
    Abstract: The present invention concerns compounds and methods of labeling peptides or other molecules with 18F or 19F or any other suitable radionuclide of use, for example, in PET or NMR in vivo imaging. A targeting molecule such as a protein or a peptide is linked to a substituted metallocene complex which is reacted with the 1gF or 19F shortly before performing the PET or NMR in vivo imaging on the patient. The labeled molecule is then used for targeting a cell, tissue, organ or pathogen to be imaged or detected.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 14, 2016
    Inventors: Guiseppe Zanoni, Alessio Porta, Marco Pazzi, Andrea Gandini, Wolfgang Karl-Diether Brill
  • IMAGING DIAGNOSTICS BY COMBINING CONTRAST AGENTS
    Publication number: 20160008496
    Abstract: The present invention relates to the use of a combination of several contrast agents having different properties with respect to imaging representation.
    Type: Application
    Filed: September 21, 2015
    Publication date: January 14, 2016
    Applicant: MIVENION GMBH
    Inventor: Ulrike WIEBELITZ
  • Method for Treating Lung Carcinoma
    Publication number: 20160008497
    Abstract: Accordingly, the present invention provides a method of treating lung neoplasia in a subject in need of treatment, by subjecting the patient to SIRT.
    Type: Application
    Filed: July 7, 2015
    Publication date: January 14, 2016
    Inventors: Jens Ricke, Holger Amthauer, Oliver Grober
  • METHOD AND ARRANGEMENT FOR STERILIZATION AND STORAGE OF MEDICAL DEVICES
    Publication number: 20160008498
    Abstract: Method of sterilization of a medical device, in particular surgical instrument, placed in a closable airtight container, including placing such medical device inside a closable airtight container; closing the container; placing a Vacuum Ultraviolet Light source against a window of said container, wherein such window is transparent to Vacuum Ultraviolet light and to UVC and/or Middle Ultraviolet light; irradiating a volume inside such closed container with Vacuum Ultraviolet Light through such window in order to generate ozone and/or ozonites within such volume; removing the Vacuum Ultraviolet Light source; and waiting for an incubation time.
    Type: Application
    Filed: February 6, 2014
    Publication date: January 14, 2016
    Inventors: Max BOYSSET, Marc SPALTENSTEIN
  • METHOD AND APPARATUS FOR THE DISINFECTION OR STERILIZATION OF MEDICAL APPAREL AND ACCESSORIES
    Publication number: 20160008499
    Abstract: The present invention provides an apparatus for disinfecting and/or sterilizing medical or laboratory apparel or accessories, comprising: a cabinet, a disinfecting system housed within the cabinet, wherein the disinfecting system comprises at least one disinfecting agent, and an embedded computer or a programmable logic controller (PLC) housed within the cabinet, wherein the embedded computer or the PLC controls one or more systems of the apparatus. The cabinet has advanced tracking features (e.g., RFID readers) that can track the apparel or accessories being disinfected. The embedded computer or PLC has the capabilities to send electronic messages to users or additional computers for further transmission of information at regular intervals. Methods for disinfecting and/or sterilizing medical or laboratory apparel or accessories are also provided.
    Type: Application
    Filed: September 18, 2015
    Publication date: January 14, 2016
    Applicant: NOSOCOM SOLUTIONS, INC.
    Inventors: NARESH SUNKARA, RICARDO R. GARCIA, NIKHIL SANTOSH NAIKAL, JAYA SUNKARA
  • METHOD AND DEVICE FOR PLASMA-TREATING HOLLOW BODIES
    Publication number: 20160008500
    Abstract: The present invention relates to a device for plasma-treating hollow bodies, such as bottles, vials, syringes, shut-off caps, etc., in particular with a view to sterilising said hollow bodies, and is equally suitable for various discharge types such as dielectric barrier discharge and discharges with high frequency and microwave excitation. The device allows a pressure gradient to be set between the interior and the exterior of the object to be treated, which can be advantageously used for process control and plasma formation and forms the basis for an optimised in-line method of plasma-treatment of hollow bodies. An essential feature of the invention is the original combination of a plasma process and a sealing system.
    Type: Application
    Filed: March 4, 2014
    Publication date: January 14, 2016
    Inventors: Joerg EHLBECK, Manfred STIEBER, Klaus-Dieter WELTMANN
  • PEN STERILIZATION DEVICE
    Publication number: 20160008501
    Abstract: A pen sterilization device includes a main body having a first end, a second end and a plurality of opposing sides defining a watertight reservoir for containing a sterilization agent. A pair of watertight valves are positioned along each end of the main body and function to allow ingress and egress of a pen to be cleaned. A partition may be provided within the watertight reservoir having one or more brushes that are suspended in the sterilization agent for scrubbing a pen that is passing through the device.
    Type: Application
    Filed: September 23, 2015
    Publication date: January 14, 2016
    Inventors: Michael Todd Roberts, John Michael Roberts, Lucas Todd Roberts
  • System and Apparatus for Disease Prevention
    Publication number: 20160008502
    Abstract: A hand sanitizer dispenser includes a body portion having a reservoir for holding a liquid. A first end of the body portion has a device for dispensing the liquid. A second end of the body portion (the second end opposes the first end) has a hook portion either formed or affixed to the second end of the body portion.
    Type: Application
    Filed: July 8, 2014
    Publication date: January 14, 2016
    Inventor: Liada LaBonte
  • AUTOCLAVE STERILIZATION CABINET
    Publication number: 20160008503
    Abstract: A sterilization cabinet for use in an autoclave. The sterilization cabinet includes one or more filtered vents permitting sterilization agent to enter and exit the interior space of the cabinet during a sterilization cycle. Each vent is occluded by a cover plate. The cover plate contains a latch configured to accept a rod extending from the center of the vent and engage a notch disposed thereon. The floor of the cabinet is shaped to direct the liquid contained within the cabinet to flow into the drain port disposed within the floor. The drain assembly is used to expel the liquid from the cabinet while preventing microbes and contaminants from entering the cabinet. The hinges connecting the door to the cabinet can be used to adjust an angle of inclination, a horizontal position, and a vertical position of the door.
    Type: Application
    Filed: September 22, 2015
    Publication date: January 14, 2016
    Inventors: Alexis Douglas Webb, Jesus Manuel Pazos, Randel Scott Kristich
  • ELEMENTS FOR DISPERSING FRAGRANCE
    Publication number: 20160008504
    Abstract: A fragrance delivery element may be configured to generate one or more vortices as air flows therethrough. The fragrance delivery element may include one or more airflow apertures, each of which may be configured to receive airflow and convert the airflow to a vortex. As air flows through each airflow aperture and past the fragrance delivery element, fragrance is emitted into the air. Emission of the fragrance may occur without heating the fragrance delivery element or the fragrance. The creation of at least one vortex may extend the distance fragrance is thrown from the fragrance delivery element. Methods and systems for dispersing fragrance are also disclosed.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 14, 2016
    Inventors: Jeffrey Alan Goodsell, Alan K. Farrell, Dallas Robinson, Jeffery W. Palmer
  • Adhesive Composition
    Publication number: 20160008505
    Abstract: The present invention relates to an adhesive composition applicable to skin comprising: (i) a polar oil or fat including (a) at least one triglyceride and/or (b) at least one fatty acid of the formula R—CO2H, wherein R is a C3 to C30 alkyl group; and (ii) at least one homopolymer, and/or copolymer. This invention also relates to a medical adhesive device including such adhesive composition.
    Type: Application
    Filed: July 14, 2015
    Publication date: January 14, 2016
    Applicant: EuroMed Inc.
    Inventors: Ravi RAMJIT, Ta Kang KENG, Jarl JENSEN
  • STEM CELL COMPOSITIONS AND METHODS FOR WOULD HEALING
    Publication number: 20160008506
    Abstract: This application provides compositions for wound repair comprising VSEL stem cells and methods for treating acute and chronic cutaneous wounds, including burns and ulcers.
    Type: Application
    Filed: March 7, 2014
    Publication date: January 14, 2016
    Inventor: Vincent FALANGA
  • ADHESIVE BONE FILLING AGENT AND ADHESIVE BONE FILLING AGENT KIT
    Publication number: 20160008507
    Abstract: Provided is an adhesive bone filling agent which adheres to bone tissue and hardens, and the adhesive bone filling agent is prepared by mixing a liquid component composed of a buffer solution comprising a water-soluble biocompatible polymer with a powder component comprising calcium phosphate and an organic acid-based crosslinking agent.
    Type: Application
    Filed: March 11, 2014
    Publication date: January 14, 2016
    Inventor: Tetsushi TAGUCHI
  • TISSUE REPAIR MATERIAL
    Publication number: 20160008508
    Abstract: A tissue repair material includes gelatin granules, and the tissue repair material exhibits a water absorptivity of 800% by mass or more, and a residual ratio of 60% by mass or less after three hours of decomposition treatment using 1 mol/L hydrochloric acid. A block-shaped tissue repair material includes gelatin, and the block-shaped tissue repair material exhibits a water absorptivity of 800% by mass or more, and a residual ratio of 60% by mass or less after three hours of decomposition treatment using 1 mol/L hydrochloric acid.
    Type: Application
    Filed: August 28, 2015
    Publication date: January 14, 2016
    Applicant: FUJIFILM CORPORATION
    Inventors: Izumi NAKAHARA, Hideo FUSHIMI, Takahiro HIRATSUKA, Ai OKAMURA, Shoji OYA, Hidekazu SAKAI, Yoshitaka OONO
  • NOVEL COLLAGEN MATERIALS AND METHODS FOR OBTAINING SAME
    Publication number: 20160008509
    Abstract: The invention relates to novel collagen materials and, specifically, collagen membranes, tubes and threads. Said materials combine enhanced properties of resilience and strength. The invention also relates to a method for preparing collagen materials using acid fibrous collagen comprising coagulation and, optionally, cross-linking of the collagen in the presence of ammonia gas.
    Type: Application
    Filed: September 21, 2015
    Publication date: January 14, 2016
    Applicant: BIOM'UP
    Inventors: Christian GAGNIEU, Patricia FOREST, Sylvain PICOT
  • Biodegradable Shape-Memory Material and Method
    Publication number: 20160008510
    Abstract: A biodegradable material with shape retention ability may be prepared using a process that includes (a) dissolving a polymer that in a first solvent to obtain a first solution; (b) dissolving a poly-N-vinyl lactam (e.g., polyvinyl pyrrolidone (PVP)) in a second solvent to obtain a second solution; (c) mixing the first solution with the second solution to obtain a liquid mixture; and (d) preparing the biodegradable material using the liquid mixture in an electrospinning process. The polymer may include a copolymer of lactide and caprolactone, where the lactide preferably includes L-lactide. The first solution may be an aprotic solvent preferably ethyl acetate.
    Type: Application
    Filed: July 13, 2015
    Publication date: January 14, 2016
    Inventor: Bronislava G. Belenkaya
  • Flowable Matrix Compositions and Methods
    Publication number: 20160008511
    Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.
    Type: Application
    Filed: September 18, 2015
    Publication date: January 14, 2016
    Inventors: Reginald L. Stilwell, Adrian C. Samaniego, Brent Atkinson
  • Flowable Matrix Compositions and Methods
    Publication number: 20160008512
    Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.
    Type: Application
    Filed: September 18, 2015
    Publication date: January 14, 2016
    Inventors: Reginald L. Stilwell, Adrian C. Samaniego, Brent Atkinson
  • TONSILLECTOMY SPONGE
    Publication number: 20160008513
    Abstract: Described are methods of performing a surgical tonsillectomy, medical devices for treating a void created by removing tonsil tissue from a patient, surgical kits, and use of an extracellular matrix material in the manufacture of a medicament for treating a surgical wound resulting from removal of tonsil tissue from a patient. Also described is a device for wound closure, and methods of making and using thereof.
    Type: Application
    Filed: July 9, 2015
    Publication date: January 14, 2016
    Inventors: Thomas Cherry, Melissa Rose Taylor, Don Patterson
  • Soft Tissue Pouch and Methods of Use Thereof
    Publication number: 20160008514
    Abstract: The invention relates to a soft tissue pouch and methods of use thereof.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 14, 2016
    Applicant: LifeNet Health
    Inventor: Alyce Linthurst JONES
  • Flowable Matrix Compositions and Methods
    Publication number: 20160008515
    Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.
    Type: Application
    Filed: September 18, 2015
    Publication date: January 14, 2016
    Inventors: Reginald L. Stilwell, Adrian C. Samaniego, Brent Atkinson
  • POLY(LACTIC-CO-GLYCOLIC ACID (PLGA) COMPOSITES WITH MAGNESIUM WIRES ENHANCED NETWORKING OF PRIMARY NEURONS
    Publication number: 20160008516
    Abstract: A bioresorbable material incorporating magnesium (Mg) wires into NGCs is disclosed. The bioresorbable material includes magnesium, and a biodegradable polymer, for example, poly(lactic-co-glycolic acid (PLGA). The bioresorbable material can include magnesium wires incorporated into a poly(lactic-co-glycolic acid (PLGA) scaffold to provide both directional and biological cues in a fully bioresorbable material. A method of producing a bioresorbable material is also disclosed, which includes placing a plurality of magnesium (Mg) wires on a layer of a poly(lactic-co-glycolic acid (PLGA) solution, placing a second layer of the poly(lactic-co-glycolic acid (PLGA) solution on the plurality of magnesium (Mg) wires, and drying the plurality of magnesium (Mg) wires between the two layers of poly(lactic-co-glycolic acid (PLGA) solution.
    Type: Application
    Filed: April 16, 2015
    Publication date: January 14, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Huinan LIU, Catherine AUGELLO, Atena ZAHEDI, Iryna ETHELL
  • ANTIMICROBIAL COATING FORMING KINK RESISTANT FEATURE ON A VASCULAR ACCESS DEVICE
    Publication number: 20160008517
    Abstract: A vascular access device includes an antimicrobial coating that provides kink resistance to a catheter. The antimicrobial coating can extend along a length of the catheter to provide antimicrobial protection when the catheter is inserted into the patient's vasculature. The antimicrobial coating can also increase the effective diameter of the catheter to minimize the likelihood that the catheter will become kinked.
    Type: Application
    Filed: July 8, 2014
    Publication date: January 14, 2016
    Inventors: Jonathan Karl Burkholz, Siddarth K. Shevgoor, Tony Farnsworth Adams
  • PHARMACEUTICAL COMPOSITIONS AND DEVICES FOR TREATMENT OF PROLIFERATIVE DISEASES
    Publication number: 20160008518
    Abstract: A balloon catheter for delivering a combination of pharmaceutical active agents to a diseased blood vessel or conduit comprising an exterior coating layer of hydrophobic drugs with a first therapeutic agent is an mTor inhibitor and a second is an NF-k? inhibitor. The pharmaceutical composition for treating proliferative diseases is further comprised of a mixture of two hydrophobic therapeutic agents coated on a medical device, with a first therapeutic agent is an mTor inhibitor and the second therapeutic agent is an NF-k? inhibitor. The device and pharmaceutical combination comprise a method for treating proliferative diseases.
    Type: Application
    Filed: July 10, 2015
    Publication date: January 14, 2016
    Inventor: Thomas Q. Dinh
  • RESORBABLE MEMBRANE FOR GUIDED BONE REGENERATION
    Publication number: 20160008519
    Abstract: The invention relates to membranes for guided bone regeneration, comprising a biodegradable polymer that has been treated with a plasma on one of the faces thereof, and on which at least one or more nanometric layers of active oxides has been deposited on one or both of the faces. The invention also relates to uses of and methods for producing said membranes and to implants based thereon.
    Type: Application
    Filed: December 24, 2013
    Publication date: January 14, 2016
    Inventors: David González Padilla, Alberto García-Perla García, José Luis Gutiérrez Pérez, Daniel Torres Lagares, Gabriel Castillo Dali, Mercedes Salido Peracaula, José Vilches Troya, José Ignacio Vilches Pérez, Antonia Terriza Fernández, Ángel Barranco Quero, Francisco Yubero Valencia, Aránzazu Díaz Cuenca, Agustín Rodríguez González-Elipe