Abstract: A method of processing a signal representing a physiological rhythm of a subject, the method comprising the steps of receiving the signal from the subject, filtering the signal with a band pass filter, extracting an analysis window from the filtered signal, performing a plurality of interval length estimation methods on the filtered signal in the analysis window, summing the outputs of the plurality of interval length estimation methods, and determining an interval length from the sum of the outputs of the plurality of interval length estimation methods.

Abstract: A stochastic Bayesian non-linear filtering system and method that improves the filtering of noisy signals by providing efficiency, power, speed, and flexibility. The filter only requires the likelihood function p(observation|state) to determine the system state and works in various measurement models. This allows for the processing of noisy signals to be used in real time, such as in a biofeedback device that senses noisy surface electromyography muscle electrical activity, filters the sensed signal using the nonlinear filtering method, and provides vibrations based on the muscular activity.

Abstract: Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and the QRS interval signals indicating ventricular activity in the ECG waveforms. In particular, the ECG electrodes on the electrode patch are tailored to be positioned axially along the midline of the sternum for capturing action potential propagation in an orientation that corresponds to the aVF lead used in a conventional 12-lead ECG that is used to sense positive or upright P-waves.

Abstract: Power saving communication techniques for communicating in a medical device system. One example medical device system may be for delivering electrical stimulation therapy to a heart of a patient, and may include a first implantable medical device implanted in a first chamber of the heart and configured to determine one or more parameters, a medical device physically spaced from and communicatively coupled to the first implantable medical device, the medical device configured to deliver electrical stimulation therapy to the heart of the patient, wherein the first implantable medical device is further configured to: compare a value of a first determined parameter to a first threshold; if the value of the first determined parameter passed the first threshold, communicate a first indication to the medical device; and if the value of the first determined parameter has not passed the first threshold, not communicating the first indication to the medical device.

Abstract: Devices for detecting electrical activity in electrically active biological tissues and methods for using the devices are provided. The devices include an electrode array that is configured for implantation on electrically active biological tissue. The electrode array comprises a plurality of electrode sites comprising one or more layers of transparent, electrically conductive graphene disposed on a transparent substrate.

Abstract: Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and the QRS interval signals indicating ventricular activity in the ECG waveforms. In particular, the ECG electrodes on the electrode patch are tailored to be positioned axially along the midline of the sternum for capturing action potential propagation in an orientation that corresponds to the aVF lead used in a conventional 12-lead ECG that is used to sense positive or upright P-waves.

Abstract: Provided is a myoelectric potential measurement device that recognizes a user arm movement, including a bracelet having a plurality of electrodes, at least one memory, and a processor.

Abstract: Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally (in the midline) on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and, to a lesser extent, the QRS interval signals indicating ventricular activity in the ECG waveforms.

Abstract: Devices and methods for monitoring pain in a subject, including a wearable device in communication with an analysis system that monitors pain in a subject using measurements of electrodermal activity in the subject are disclosed.

Abstract: Volumetric Electromagnetic Phase Shift Spectroscopy (VEPS)-based methods of analyzing a tissue are provided. Aspects of the methods comprise obtaining a VEPS-based tissue classifier, or “signature” for a tissue at a single point in time. These methods find particular use in non-invasively determining the condition of a tissue, e.g. brain tissue, lung tissue, heart tissue, muscle tissue, skin tissue, kidney tissue, cornea tissue, liver tissue, abdomen tissue, head tissue, leg tissue, arm tissue, pelvis tissue, chest tissue, trunk tissue, prostate tissue, breast tissue, esophagus tissue, GI tract tissue, etc., in an individual. Devices and systems thereof that find use in practicing the subject methods are also provided.

Abstract: A sensing system includes an off-axis coil in which wire is wound in loops about a roll axis and at an angle to the roll axis. In particular, the loops define respective areas that have a normal direction at a non-zero angle relative to the roll axis. A field generator can generate a variable magnetic field through the coil, and sensor logic can be coupled to the coil and configured to determine a measurement of a roll angle of the coil about the first axis using an electrical signal induced in the coil.

Abstract: Systems and methods for integrating and/or registering a shape sensing fiber in or to various instruments are described herein. Registration fixtures and registration techniques for matching the coordinate system of a fiber to the coordinate system of an elongate instrument or other device are provided. Various systems and methods for integrating a shape sensing fiber into an elongate instrument or other device are also described herein.

Abstract: A device and method for measuring the breathing of an individual being mechanically ventilated is presented, the device having a conduit configured as a Venturi tube with a gas flow path therethrough. Pressure transducers are located at positions in the gas flow path such that flow rate and/or other flow parameters may be determined.

Abstract: The present invention relates to apparatus (10) for determining a respiration volume signal from a subject (12), comprising a processing unit (28) for receiving image data (26) detected from a field of view (42) and for determining an alternating signal (S)including vital sign information (R) of the subject (12) from the image data (26), an analysis unit (30) for determining at least one characteristic parameter (A) corresponding to a respiration parameter of the subject (12) on the basis of the alternating signal (S), a calibration unit (32) for determining a calibration value (V1, V2) on the basis of a breathing volume measured during inhale and/or exhale of the subject (12) by means of an airflow or an air volume measurement, and a calculation unit (34) for calculating the respiration volume of the subject (12) on the basis of the calibration value (V1, V2) and the at least one characteristic parameter (A).

Abstract: Apparatus is disclosed for measuring the circumference of a limb of an individual, e.g., the individual's arm and/or calf. The apparatus uses one or more magnetic strips which surround the limb and contain magnetic coding of length information. Tension is applied to the magnetic strip by a tensioning assembly, which can be a pressure cuff or a stepping motor, and a magnetic read head reads the magnetic coding of length information from the strip. When used in a bioimpedance analysis procedure, the length information can be used to convert measured voltage differences into normalized bioimpedance values, e.g., resistivity values.

Abstract: There is described an integrated unweighted gait training system having an unweighting system comprising a computer controller; a gait measurement system in communication with the controller; and a display in communication with the computer controller adapted and configured to provide real-time feedback to a user of the integrated unweighting gait training system. The unweighting system may be a differential air pressure (DAP) unweighting system or a non-DAP unweighting system.

Abstract: A bed-leaving sensor for detecting bed-leaving by a user on a bed, including: a sitting position detection member that detects a sitting position of the user based on a detection value of a pressure sensor arranged on the bed; a foot movement detection member for detecting foot movement of the user based on the detection value of the pressure sensor; and a bed-leaving behavior detection member that detects bed-leaving behavior of the user with the sitting position or the foot movement being detected within a preset bed-leaving expectation region as a condition.

Abstract: A bed-leaving sensor for detecting bed-leaving by a user on a bed, including: a sitting position detection member that detects a sitting position of the user based on a detection value of a pressure sensor arranged on the bed; and a bed-leaving behavior detection member that detects bed-leaving behavior of the user with at least one of the following as a condition: (i) the sitting position being detected within a preset bed-leaving expectation region, (ii) a movement volume of a sitting position center of gravity which is a center of gravity of the sitting position exceeding a given threshold value within a given time, and (iii) the sitting position center of gravity moving toward a preset bed-leaving range.

Abstract: The invention relates to a device and method for monitoring physical activity of a person. The device comprises an acceleration sensor for providing acceleration data corresponding to movements of the person, a memory unit capable of storing an activity index value describing cumulative physical activity of the person, and data processing unit capable of being operated in at least a first activity monitoring mode in which the data processing unit is adapted to update the activity index value based on the acceleration data. In addition, the processing unit is, in the first activity monitoring mode, configured to determine if, and to update the activity index value only if, the acceleration data corresponds to walking- and/or running-related movements of the person. The invention allows for robust monitoring of activities that have an impact on fitness and health of individuals and reduce the risk of incorrect activity recordings.

Abstract: Improved techniques and systems to calibrate an electronic device that is providing activity sensing are disclosed. The activity being sensed can, for example, correspond to walking or running by a user. In one embodiment, calibration can be performed by a portable electronic device so that activity data it receives from a remote sensor device can be more accurately processed. The improved techniques and systems to calibrate can be used to monitor, process, present and manage data captured by a remote sensor. The portable electronic device can also offer a convenient user interface that can be visual and/or audio based, customized to a particular application, user-friendly and/or dynamic. The portable electronic device can pertain to a portable media player and thus also provide media playback.

Abstract: A method, apparatus, and a kit are capable of improving accuracy of CGS devices using dynamic outputs of continuous glucose sensors.

Abstract: A method and an apparatus for measuring glucose level in the body fluid of a subject, typically blood glucose level, by measuring impedance of a body tissue, with two pairs of electrodes, two electrodes for injecting current into a body tissue and two electrodes for detecting the ensuing voltage of the body tissue. The body tissue is typically a sub-dermal or sub-cutaneous tissue. The measured impedance of the body tissue is used to correlate with directly determined glucose levels to determine the glucose level from the measured impedance. It is thus possible to determine body fluid glucose levels in a reliable and reproducible manner.

Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

Abstract: Devices, systems and methods are provided for the real-time detection of disease through constant or periodic monitoring of biomolecules in an individual without laboratory sampling. Biomolecule detector devices may be worn in contact with skin, or be implanted in fluid communication with a biological fluid to provide information and identity of disease-related circulating biomolecules in an individual.

Abstract: The present invention provides an optical sensor unit (10) for measuring gas concentration, comprising: sensor means (12, 13) and first thermal insulation means (14, 16) at least partially surrounding said sensor means (12, 13). The sensor means (12,13) includes at least one sensing layer (12) adapted to be irradiated with a predetermined radiation (100), and at least one gas-permeable layer (13) adjacent to one side of the at least one sensing layer (12) and adapted to pass gas, which concentration is to measured, through the gas-permeable layer (13) towards the at least one sensing layer (12). The optical sensor unit (10) is adapted to measure an optical response of the at least one sensing layer (12), which optical response depends on the gas concentration.

Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

Abstract: The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis.

Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Abstract: Lancet device includes a housing, a removable front cap mounted to the housing, a lancet holding member, and a trigger. A system is utilized for placing the lancet device in a trigger-set or armed position. A depth adjustment system includes a member that is at least partially rotatably mounted and that has an axis of rotation arranged substantially perpendicular to a center axis of the lancet holding member. An ejection system is utilized for at least one of preventing axial movement of the lancet holding member and removing or ejecting a lancet from the lancet holding member.

Abstract: Computer based systems and methods for estimating a user state are disclosed. In some embodiments, the methods comprise inputting a first input at an intermittent interval and a second input at a frequent interval into a user state estimation model to estimate the user state. In some embodiments, the first inputs are enhanced by injecting a noise input to create a plurality of enhanced first inputs whereby the plurality of enhance first inputs correspond to the plurality of second inputs at the frequent interval. In some embodiments, the first input comprises a self-reported input and the second inputs comprise a physiological input, a performance input or a situational input. In some embodiments, a machine learning algorithm creates the state estimation model. In some embodiments, the state estimation model estimates a future user state. In some embodiments, a computer based system for estimating a user state is provided.

Abstract: The present invention relates to a rapid and accurate polymer-based electrochemical point-of-care (POC) single platform assay for a multi-biomarker detection from whole blood to monitor renal function, including the identification of allograft dysfunction.

Abstract: A hose segment, and a device for using the hose segment, to regulate a volumetric flow rate, including the hose segment through which fluid can flow, and a hose clamp including a basic housing having an accommodating region for the hose segment and a clamping element that can be moved between at least two regulation positions. The clamping element has an effect on the hose segment in interaction with segments of the accommodating region as pressing points at least in one regulation position.

Abstract: A method, device, and system for assessing the quality of balance, the device comprising a plate for receiving the feet of a subject and mounted on a plurality of pressure sensors measuring vertical forces applied to the plate, wherein the method comprises the following steps: measuring, by the pressure sensors thereof, vertical forces applied to the plate, at least before and while the subject mounts the device; calculating, according to the measured values, parameters that are relevant for the assessment, including at least one parameter relating to at least one slowdown in the rise of the values measured by the pressure sensors thereof when the subject mounts the device.

Abstract: A system for assessing the stability of a person relative to a horizontal surface during an assessment session is provided. The system includes a platform having a stage upon which the person stands. A sensing configuration senses when the person is unbalanced on the stage, and conveys this information to a processor. The processor converts this information into meaningful graphics for viewing on a display.

Abstract: A system and method for assessing a patient's balancing ability in order to facilitate ascertaining the patient's current medical status. The system includes a balance plate for measuring the center of gravity dynamic weight distribution in combination with a sensor for measuring the patient's fine motor skills.

Abstract: This document discusses, among other things, systems and methods configured to receive affect information from a patient in response to a provided affect inquiry and to receive real world activity information from the patient in response to a provided real world activity, and to provide patient neurofunction assessment information using the affect information and the real world activity information.

Abstract: An array of methods for assessing vaginal atrophy are disclosed. The methods may be used alone or in combination with a treatment or as part of a kit.

Abstract: The present invention relates to a method of diagnosing, or providing a prognosis to, or for providing the likelihood of developing, malignant melanoma in a subject, the method comprising the steps of: (a) measuring two or more markers in blood perfusion dynamics at and/or around a skin lesion site; and (b) determining if the two or more markers is different to a normal value. The invention also relates to a device for diagnosing/providing a prognosis to/for malignant melanoma in a subject.

Abstract: The present invention provides a hair testing device and a hair testing system. The hair testing device includes a data acquisition part and a transmitting part. The data acquisition part is configured to acquire hair-related data and send the acquired data to the transmitting part. The transmitting part is configured to receive the acquired data and transmit the acquired data to a data processing device which is capable of processing data. The hair testing device further includes a fixing part for fixing to hair, and the data acquisition part and the transmitting part are both located on the fixing part. The hair testing device provided by the present invention is capable of automatically acquiring hair-related data, and sending the acquired data to the data processing device for processing, so as to achieve automatic testing of hair quality.

Abstract: A knee balancing system for measuring performance parameters associated with an orthopedic articular joint comprises a force sensing module and one or more inertial measurement units. The force sensing module comprises a housing that includes an articular surface having a medial portion and a lateral portion, each of which is substantially mechanically isolated from the other. The force sensing module also includes first and second sets of sensors disposed within the housing. The first set of sensors is mechanically coupled to the medial portion of the articular surface and configured to detect information indicative of a first force incident upon the medial portion of the articular surface. The second set of sensors is mechanically coupled to the lateral portion of the articular surface and configured to detect information indicative of a second force incident upon a lateral portion of the articular surface.

Abstract: A method guides evasive actions to avoid effects of a cognitive impairment state. A first buffer, which is communicatively coupled to at least one sensor on a wearable sensor device, is loaded with a first set of sensor readings. The wearable sensor device receives a first cognitive impairment state signal based on an observer of a wearer of the wearable sensor device observing an impairment to a cognitive state of the wearer of the wearable sensor device. Subsequently, a second buffer on the wearable sensor device initiates loading of a second set of sensor readings, and the first buffer and the second buffer are compared. In response to sensors readings from the first and second buffers matching, an alert is issued to the wearer of the wearable sensor device, thus prompting the wearer to take evasive steps to avoid a recurrence of the impairment.

Abstract: A breathing guidance system having an active biofeedback mechanism is provided. The breathing guidance system includes a physiological status detection device, a processing device, a breathing indication device and an instant breathing detection module. The physiological status detection device detects at least one of instant physiological status information of the user. The processing device generates an ideal breathing waveform according to the instant physiological status information to further generate a control signal. The breathing indication device generates a breathing indication signal according to the control signal. The instant breathing detection module detects instant breathing status information of the user. The processing device further generates an instant breathing waveform according to the instant breathing status information to compare the ideal breathing waveform and the instant breathing waveform to generate a breathing condition indication signal.

Abstract: A method for communicating activity-related notifications to a user includes: receiving a record of activity events of a particular activity type performed by the user over a period of time; selecting a first time-based filter from a set of time-based filters; identifying a cluster of activity events in the record of activity events filtered according to the first time-based filter; identifying an early bound and a late bound on start times of activity events of the particular activity type from the cluster; communicating a notification of a first type to the user at a first time within a threshold time of the early bound on a day fulfilling the first time-based filter; and communicating a notification of a second type to the user at a second time within a threshold time of the late bound on a day fulfilling the first time-based filter.

Abstract: The present invention relates to a device, a system and a method for measuring the lung function and the inhalation technique of a human subject, to facilitate the empowerment of patients to self-manage airway diseases, in particular asthma. The device according to the invention comprise a first part capable of measuring the time (s) and volume of air/time (v/s) exhaled from the human subject during a single inhalation, thereby providing a measurement of the lung function, and further comprising a second part capable of measuring the acceleration (m/s2) of air and volume of inhalation from the human subject during a single inhalation, thereby providing a measurement of the inhalation technique, the second part of the device further comprising means for applying metered resistance to the inhalation, the applied resistance impairing the acceleration (m/s2) of air and volume of inhalation from the human subject during the inhalation.

Abstract: Systems, apparatus, and methods of monitoring and reducing snore are discussed herein. Some embodiments may provide for a system including a snore detection module, a movement detection module, a control module, and an actuation module. The snore detection module may be configured to detect snore, such as by detecting vibrations caused by snoring. When snoring is detected, the control module may be configured to instruct the actuation module to apply stimulation to the user that is calibrated to cause the user to shift sleeping position without disturbing sleep. The movement detection module may be configured to monitor user movement. If the user fails to move in response to the actuation, the actuation module may increase the intensity of the actuation. If the user responds to the actuation, the process may be repeated after a predetermined delay to provide continuous snore monitoring and correction throughout user sleep.

Abstract: Adaptive performance trainer for guiding a user toward a psychophysiological state. In an embodiment, psychophysiological signal data is received from one or more sensors, and a current psychophysiological state of a user is determined based on the psychophysiological signal data. The current psychophysiological state is compared to one or more goal states, and one or more control signals are generated based on a difference between the current psychophysiological state and the one or more goal states. The control signal(s) cause one or more feedback devices to generate feedback to guide the user toward the one or more goal states. The feedback may comprise an indication to the user of the current psychophysiological state at a pace that replicates the user's heartbeat.

Abstract: A biological information detecting device includes a first light reception unit which receives light from a subject, a second light reception unit which receives light from the subject, at least one light emission unit which emits light to the subject, and a processing unit. When a distance between the light emission unit and the first light reception unit is L1, and a distance between the light emission unit and the second light reception unit is L2, L1<L2 is satisfied. The processing unit determines an active state of the subject on the basis of a first detection signal detected by the first light reception unit and a second detection signal detected by the second light reception unit, and controls the biological information detecting device according to the active state.

Abstract: A system and method for diagnosing a fluid status of a patient includes non-invasively determining a left ventricular pressure of blood within a left ventricle of a heart of the patient. The left ventricular pressure is compared to a predefined pressure value to diagnose the fluid status.

Abstract: Example headsets and methods for gathering electroencephalographic signals are disclosed herein. An example headset includes an adjustment assembly including a first support to be disposed on a first side of a head of a person and a second support to be disposed on a second side of the head of the person. The example headset also includes an adjustor operatively coupled to the first support. Further, the example headset includes an electrode strip and a tension strap having a first end operatively coupled to the adjustor and a second end operatively coupled to the second support.

Abstract: Described herein is a biometric sensor package. In particular, a biometric sensor package for integration with a garment. Furthermore, methods of manufacturing of such biometric sensor packages are disclosed. Still yet, methods of integrating biometric sensor packages in to garments are disclosed. The biometric sensor packages described herein can easily be manufactured by current biometric sensor manufactures, for example heart rate monitor belt manufacturers. The biometric sensor packages described here can then be easily integrated in to garments by current garment manufacturers without requiring any special knowledge or tooling relating to the actual biometric sensor arrangements within the biometric sensor packages. Through the use of biometric sensor packages described herein biometric sensor arrangements, such as heart rate monitors and EEG sensors can be easily integrated into garments, such as sports bras, shirts and shorts, without disrupting existing supply chains and factories.