Abstract: A flexible chemiresistor (CR) sensor for sensing a molecule of interest in a fluid (liquid or gas) is provided. The flexible CR sensor comprises a flexible chemiresistor (CR) module. The flexible CR module comprises a flexible substrate such polyethylene terephthalate (PET), polyethylene naphthalate (PEN) or polyimide (PI), and a thin film nanoparticle assembly assembled on the flexible substrate. The thin film nanoparticle assembly comprises metal or metal alloy core, ligand-capped nanoparticles and molecular linkers connecting the nanoparticles. The flexible CR sensor and an intelligent pattern recognition engine can be incorporated in a handheld device that can detect a molecule of interest in a fluid (e.g., a liquid or gas) accurately, rapidly, and without false positives. Any sensing array nanomaterial, pattern recognition, and compact/or electronic hardware can be integrated to achieve a desired detection limit and response speed.

Abstract: The present invention relates to a biochip comprising an electrode having a titania coating layer on its surface; an organic coupler comprising two or more carboxylic acid groups and capable of transporting electrons; and bioactive molecules, wherein the organic coupler is covalently bonded to a hydroxyl group of titania on the electrode surface through one carboxylic acid group, and to the bioactive molecules through other one or more carboxylic acid groups, a method for analyzing target molecules using the biochip, a method for diagnosing the development of diseases using the biochip, an electrode provided with a titania coating layer on its surface to which an organic coupler, comprising 2 or more carboxylic acid groups and capable of transporting electrons, is bound, wherein the organic coupler is covalently bonded to a hydroxyl group of titania on the electrode surface through one carboxylic acid group, and a method for preparing the electrode provided with a mesoporous titania coating layer, the method

Abstract: The present invention relates a setting method for a conductive object of electrochemical test strip. In the embodiment, this manufacturing process is not complex, convenient, and has well precision, such that the cost of manufacturing an electrochemical test strip is reduced effectively, and the disadvantage of past manufacturing process is improved. The present invention is highly applied and convenient, so that wide application can be expected in the future.

Abstract: A measurement apparatus to measure a physical quantity related to a measurement target by use of a sensor, comprising: an apparatus enclosure; a control unit to be electrically connected to the sensor; and a moving member including a sensor holding unit to hold the sensor, the moving member being movable to protrude the sensor holding unit outwardly of the apparatus enclosure and further including a conductive member to electrically connect the sensor to the control unit.

Abstract: The present disclosure provides an orientation-nonspecific sensor port for use in analyte meters designed to detect and quantify analyte levels in a fluid sample along with methods of using the same. The present disclosure also provides compositions and methods for facilitating the correct insertion of a sensor into a corresponding analyte meter.

Abstract: Biosensor system measurement devices used to determine the presence and/or concentration of an analyte in a sample include normalized calibration information relating output signal or signals the device generates in response to the analyte concentration of the sample to previously determined reference sample analyte concentrations. The measurement devices use this normalized calibration information to relate one or more output signals from an electrochemical or optical analysis of a sample to the presence and/or concentration of one or more analytes in the sample. The normalized calibration information includes a normalization relationship to normalize output signals measured by the measurement device of the biosensor system and at least one normalized reference correlation relating normalized output signals to reference sample analyte concentrations.

Abstract: Miniature resistive gas detectors incorporate thin films that can selectively identify specific gases when heated to certain characteristic temperatures. A solid state gas sensor module is disclosed that includes a gas sensor, a heater, and a temperature sensor, stacked over an insulating recess. The insulating recess is partially filled with a support material that provides structural integrity. The solid state gas sensor module can be integrated on top of an ASIC on a common substrate. With sufficient thermal insulation, such a gas detector can be provided as a low-power component of mobile electronic devices such as smart phones. A method of operating a multi-sensor array allows detection of relative concentrations of different gas species by either using dedicated sensors, or by thermally tuning the sensors to monitor different gas species.

Abstract: A gas sensor element having a porous protective layer with excellent water repellency. Provided is a gas sensor element having a detection portion, which has a stack of a solid electrolyte body having a pair of electrodes on opposite sides thereof and a heat generating body including a heat generating source, and a porous protective layer formed around the detection portion. The porous protective layer has thermal conductivity ? in the range of 0.2 to 5 W/mK, and has ?Cpp, which is the product of the thermal conductivity ?(W/mK), density ?(g/m3), and specific heat Cp(J/gK), in the range of 5.3×105 to 2.1×107 WJ/m4K2.

Abstract: Low concentrations of silicon in an etchant solution comprising phosphoric acid, an organo-silicon compound and water are analyzed by adding predetermined concentrations of a carboxylic acid and fluoride ions to a test solution comprising a predetermined volume of the etchant solution, and measuring the potential of a fluoride ion specific electrode (FISE) in the test solution. Reaction with silicon ions in the test solution reduces the concentration of fluoride ions, which are present in stoichiometric excess, so that the silicon concentration of the etchant solution can be determined from the difference between the predetermined and measured concentrations of fluoride ions in the test solution.

Abstract: Various aspects are described for selectivity capturing cells or bioparticles on designated surfaces in dielectrophoretic systems and processes. A particular adhesive composition is described for enhancing cell retention. In addition, certain permeable polyester membranes used in the systems and processes are also described.

Abstract: Described is a device that is able to distinguish different nucleic acid concentrations in whole blood or plasma sample directly in under 10 min. By using this device, cell-free DNA in whole blood or plasma can be quantified without extensive sample preparation. The device contains a sample channel, an accumulation channel and a pair of electrodes. Optionally, the device includes power supply connected to the electrodes for generating an electric field to move the DNA from the sample channel to the collection channel, and a sensor to quantify the amount of cell free DNA in the collection channel. Also provided are methods for providing a prognosis for a subject with sepsis or suspected of having sepsis comprising quantifying nucleic acid concentrations in a sample from a subject using a device as described herein.

Abstract: An ionization method for use with mass spectrometry or ion mobility spectrometry is a small molecule compound(s) as a matrix into which is incorporated analyte. The matrix has attributes of sublimation or evaporation when placed in vacuum at or near room temperature and produces both positive and negative charges. Placing the sample into a region of sub-atmospheric pressure, the region being in fluid communication with the vacuum of the mass spectrometer or ion mobility spectrometer, produces gas-phase ions of the analyte for mass-to-charge or drift-time analysis without use of a laser, high voltage, particle bombardment, or a heated ion transfer region. This matrix and vacuum assisted ionization process can operate from atmosphere or vacuum and produces ions from large (e.g. proteins) and small molecules (e.g. drugs) with charge states similar to those observed in electrospray ionization.

Abstract: The invention relates to improved systems and methods for inspecting the tubes of a steam generator of a nuclear reactor that involves modeling the steam generator, comparing signals of a tube from an eddy current sensor with aspects of the model to determine whether further analysis is required, employing primary and secondary analysis processes, and producing a combined report of the primary and secondary analyses results.

Abstract: A sensor operable to sense a characteristic of a fluid. The sensor includes a sensing area, a filter, and a transducer. The sensing area is configured to contain the fluid. The filter covers the sensing area. The filter is configured to allow a liquid portion of the fluid to enter the sensing area and substantially prohibit a gas portion of the fluid to enter the sensing area. The transducer is operable to output a pulse of sound through the liquid portion of the fluid contained within the sensing area, receive the reflected pulse of sound, and output a characteristic of the fluid based on the received pulse of sound.

Abstract: Methods, systems and computer program products for determining a mechanical parameter for a sample having a target region, include determining a prior probability density function that characterizes at least one physical property of the target region; generating a displacement of the sample in the target region to form a shear wave that propagates orthogonal to a direction of the displacement; transmitting tracking pulses in the target region; receiving corresponding echo signals for the tracking pulses in the target region at a plurality of lateral positions; estimating a propagation parameter of the shear wave in response to the echo signals and the prior probability density function using statistical inference; and determining at least one mechanical parameter of the target region based on the estimated propagation parameter.

Abstract: The present invention provides a detector and method for detecting substances in complex mixtures. The detector includes a microfabricated preconcentrator, a separation column with an on-chip thermal conductivity detector, a controller for controlling flow and thermal management and a user interface. The thermal conductivity detector includes a first resistor located at an inlet of the separation column and a second resistor located at an outlet of the separation column.

Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatographic column. The restrictors include a restrictor body having a fluidic channel with an inlet that receives the mobile phase from the column and an outlet through which the mobile phase leaves the fluidic channel. A restrictor tip, disposed adjacent the outlet of the fluidic channel, has an egress opening that is smaller than an internal diameter of the fluidic channel. A heating element, thermally coupled to a subsection of the fluidic channel between its inlet and outlet, heats the mobile phase passing through that subsection of the fluidic channel. The restriction produced by the restrictor tip in response to the heating of the mobile phase enables independent control of system pressure and linear velocity of the mobile phase within the column.

Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.

Abstract: Analytical electronics used to identify compositions and structures of substances, in particular, to the analyzers comprising at least one mass-spectrometer (MS) and may be applied in such fields as medicine, biology, gas and oil industry, metallurgy, energy, geochemistry, hydrology, ecology. Technical result provides the increase in MS resolution capacity, gain in sensitivity, precision and measurement rates of substances compositions and structures concurrently with enhancement of analyzer functional capabilities, downsizing and mass reduction. A multipath method of mass-spectrometry and a three-dimensional reflecting (3D-reflecting) method of mass-spectrometry requiring to use a three-dimensional reflecting IO sub-system (3D-reflector) are developed. A new type of electric field distribution such as transversely discontinuous conic field distribution, including its type of three-dimensional distribution in area of reflection, is proposed to implementing said methods.

Abstract: Certain embodiments described herein are directed to inserts and ion sources. In some examples, an insert can comprise a positioning guide configured to provide for visual positioning of a chromatography column under the positioning guide. In other examples, an ion source configured with an aperture to couple to a carrier tube to render the ion source non-removable from an instrument housing when the carrier tube is coupled to the ion source is described.

Abstract: A preparative separation chromatograph system having a column for temporally separating components in a sample and for discharging an eluate fluid with the components, a detector for obtaining an absorbance spectrum of the eluate fluid, and a fraction collector for continuously creating a chromatogram. The system further includes: a peak section determiner; a differential value determiner for calculating a differential spectrum value and for determining whether or not the absolute value of the differential spectrum value is equal to or less than a predetermined value; and a fraction collector controller for controlling the fraction collector so as to fractionate the eluate fluid during a period of time for which it is determined that the chromatogram peak of the target component is present and for which it is also determined the absolute value of the differential spectrum value is equal to or less than the predetermined value.

Abstract: Provided herein is technology relating to detecting gaseous analytes and particularly, but not exclusively, to devices and methods related to detecting gaseous analytes by monitoring changes in liquid crystals upon exposure to the gaseous analytes.

Abstract: A method for operating a measuring site (1), wherein a measured variable is determined by a sensor (5) that can be calibrated and in which an exact as possible planning of activities, to which, for example, calibration or sensor replacement belong, is possible is obtained, in accordance with the method, in that the sensor (5) is calibrated at presettable calibration points in time, that at least one parameter in conjunction with calibration is stored as a part of reference data of the sensor (5) and that at least one aging-dependent variable of a sensor (8, 6) differing from the sensor (5) is estimated based on reference data of the sensor (5).

Abstract: There are provided methods for analyzing air including monitoring the air. For example, monitoring the air includes electronically sensing the air and determining whether an event in the air is occurring based on at least the electronically sensing. If an event is occurring, a sample of the air is collected for a further analysis. For example, the analysis is carried out to identify components present in the sample. There are also provided systems for analyzing air comprising : an air intake; an electronic sensor and a controller configured to monitor the air. Monitoring air includes controlling the air intake, controlling the electronic sensor to electronically sensing the air and determining whether an event in the air is occurring based on at least the electronically sensing. If an event is occurring, a sample of the air is collected for further analysis (e.g. to identify components present in the sample).

Abstract: A method of testing an air sample and/or testing equipment may comprise introducing aerosolized sample particles into an air flow to create sample air upstream from an air quality sampling device. The method may include introducing the sample air to an offset sample inlet of a bell cap inlet adaptor coupled to a sample tube. The method may include merging at least a portion of the introduced sample air with axially flowing air with little to no turbulence based on the geometry of the bell cap inlet adaptor and/or a containment cavity. The method may include introducing at least a portion of the sample air into the sample tube. Next, a test of at least one of the quality of the sample air and/or the functionality of the bell cap inlet may be performed.

Abstract: In one embodiment, authentication of a beverage is performed by forming an airtight seal with a bottle that contains the beverage, the bottle being sealed with a closure, applying a vacuum to the bottle to draw a sample from the closure that includes traces of the beverage, collecting the sample over time as the vacuum is applied to the closure, and performing testing on the collected sample.

Abstract: A method for determining the total organic carbon in a sample which includes mixing the sample with a reagent containing at least one acid effective for reacting with inorganic carbon-containing materials in the sample, and at least one oxidizing agent effective for oxidizing organic carbon-containing materials in the sample in the presence of ultraviolet radiation, and detecting the carbon dioxide generated, is described. The at least one acid may include phosphoric acid, while the oxidizing agent may include sodium persulfate. In accordance with an embodiment of the inventive concept, the sample is first injected into a reaction chamber, which is continuously flushed with carbon dioxide free gas with no UV light present, and CO2 generated from any inorganic carbon in the sample as carbonates is flowed through the detector, and may be recorded.

Abstract: Method and system is described for hydrocarbon exploration and development. The method and system include one or more remote devices, such as buoys, which are utilized to identify and collect samples of target materials. The buoys include measurement components, sampling components and storage components to manage the obtained samples.

Abstract: Properties of coal are determined from samples processed by a near-infrared spectroscopy (NIR) device that generates wavelengths dependent spectra. Target values of the properties are associated with the NIR spectra by a kernel based regression model generated from training data based on an anisotropic kernel function that is extended by defining the kernel parameters as a smooth function over the wavelengths associated with a spectrum. Like the anisotropic case each wavelength related dimension has its own kernel parameter. Adjacent dimensions are restricted to have similar kernel parameters. Measured spectra with a limited number of features are reconstructed by applying a regression model based on training data of spectra having an extended number of features. Training data are pruned based on a regression model by removing outliers.

Abstract: A geomechanical fluid-solid coupling testing device for water inrush from coal mine collapse column is disclosed, which comprises a testing bed and a collapse column simulating device, wherein the testing bed has a box type structure with an opening at its top and is provided therein with multiple layers of similar materials in which a tunnel or a mining face can be dug out; and the collapse column simulating device comprises a plexiglass barrel with openings at both its top and bottom, the plexiglass barrel is provided at its top opening with a plexiglass lifting device and a hard plastic baffle, and the plexiglass lifting device is provided with a lifting level which is connected with a lifting rope.

Abstract: A filtration system for a soil analysis device and methods of pressure filtration and automated cleaning are disclosed for generating filtrate used in measuring characteristics of a soil sample and preparing the filtration system for repeated measurements. A mixing chamber combines a soil sample and an extractant into a liquid mixture. The filtration system receives and pressure filters the liquid mixture to quickly generate filtrate used to measure characteristics of the sample. The filtrate is passed to a measurement cell for analysis. Once the analysis is complete, the filtration system performs a cleaning process in preparation to receive a subsequent liquid mixture from another soil sample.

Abstract: System includes a sensor operably coupled to a device body. The sensor includes a sensing region and at least one resonant inductor-capacitor-resistor (LCR) circuit. The sensing region is configured to be placed in operational contact with an industrial fluid. The at least one resonant LCR circuit is configured to generate an electrical stimulus that is applied to the industrial fluid via electrodes at the sensing region. The device body includes one or more processors configured to receive an electrical signal from the sensor that is representative of a resonant impedance spectral response of the sensing region in operational contact with the industrial fluid responsive to the electrical stimulus. The one or more processors are further configured to analyze the resonant impedance spectral response and determine both a water concentration in the industrial fluid and an aging level of the industrial fluid based on the resonant impedance spectral response.

Abstract: A system includes a sensor, one or more processors, a transmitter, and a capacitance control structure. The sensor is configured to contact a fluid and measure a characteristic of the fluid. The one or more processors are operably coupled to the sensor. The one or more processors are configured to generate one or more data signals representative of the characteristic of the fluid that is measured by the sensor. The transmitter is operably coupled to the one or more processors. The transmitter is configured to wirelessly communicate the one or more data signals to a remote reader. The capacitance control structure is configured to one or more of reduce or isolate sensor capacitance of the sensor from the one or more processors.

Abstract: A sensing device includes a shell comprising an elastomeric material, the shell including a first portion having a first end and a second portion having a second end. The shell may be egg-shaped. The first portion includes a conducting disc and a plate that includes a temperature sensor, a location sensor, and a micro-fiber composite sensor. The first portion also includes an antenna and a first electrode extending through a first hole in the first portion of the shell. The second portion includes a quantity of a metallic substance embedded on the inside surface of an end of the second portion, and a second electrode extending through a second hole in the second portion of the shell. The sensing device may be inserted into a concrete mixture, obtain measurements relating to the concrete mixture, and transmit data to a database.

Abstract: Embodiments of the present disclosure are directed to methods, systems and devices, for analyzing the molecules. For example, in some embodiments, a system is provided which includes a first volume of conducting fluid, a second volume of conducting fluid, an orifice in communication with said first and second volumes of fluid, and means for applying an electric potential difference between said first and second volumes of fluid. In some such embodiments, a conjugate product is provided which comprises charged polymers each having attached thereto at least one first molecule for analysis, where the product carries a predetermined charge greater than the charge on the first molecule, and upon dissolving a product in the first volume of fluid, the product is directed into the orifice.

Abstract: The present disclosure relates to a test strip handling device (100) that includes a housing (110) having an interior compartment (112) in which the test strips are received and stored. The device (100) facilitates sanitary handling and disposal of the test strips.

Abstract: A disposable cartridge adapted to be used with a sensor-dispensing instrument comprises a housing, test sensors, a mechanical mechanism and moveable seals. The housing forms at least one opening therethrough. The test sensors are stacked in the housing. The test sensors are adapted to assist in testing at least one analyte. The mechanical mechanism is adapted to urge the test sensors in a first direction. One of the test sensors is positioned for ejection from the cartridge. The moveable seals is adapted to be in a closed position that seals the at least one opening so as to provide a substantially moisture-proof and a substantially air-tight cartridge, and one of the moveable seals is adapted to be in an open position that allows one of the test sensors to be moved therethrough.

Abstract: Perfusion device for the dynamic analysis of the thrombotic-ischemic and hemorrhagic pathology, comprising at least one micro-channel (54) able to be connected to a circuit (13) and in which a fluid is able to flow, such as a biological fluid, like blood or other hematic fluids, whether they are animal or human fluids and mixtures of said fluids with additive substances, or a non-biological fluid, and in which at least one reactive substrate is present, intended for the analysis to be carried out, such as a cytoadhesive substrate, in order to simulate a damaged vasal surface and to reproduce hemostasis phenomena and processes. The perfusion chamber is made of a material which allows the optical acquisition in fluorescence light and/or in visible light of images or videos of the flow of fluid inside the at least one micro-channel (54).

Abstract: The present invention relates to a process for evaluating in vitro at least one active agent capable of preserving the functionality of epithelial stem cells, in particular of maintaining or stimulating the growth and/or the density and/or the renewal of a keratin material, consisting in determining the ability of the active agent(s) to mimic a hypoxic state in the keratin material, the active agent(s) being capable of increasing the expression of at least carbonic anhydrase IX as biological marker of hypoxia, in the keratin material treated with the active agent(s) compared with the keratin material not treated with the active agent(s). It also relates to the use of such a process.

Abstract: An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.

Abstract: The disclosure relates to methods for measuring levels of 25(OH)vitamin D (250HD) in a mammalian fluid sample. The disclosure further relates to kits for measuring levels of 25(OH)vitamin D (250HD) in a mammalian fluid, the procedure comprising the step of release of the vitamin D from the serum binding protein (DBP), capturing of the released analyte by a specific antibody and competitive assay of the captured vitamin D against a conjugate between the vitamin D and a tracer. The observed signal is inversely proportional to vitamin D concentration.

Abstract: The present invention is a sensor for detecting a microorganism, which is provided with a detection unit equipped with a detection electrode and a polymer layer, wherein the polymer layer is arranged on the detection electrode and is provided with a template having a three-dimensional structure complementary to a three-dimensional structure of a microorganism to be detected. The sensor detects a microorganism on the basis of the captured state of the microorganism onto the template. The polymer layer is formed by a manufacturing method including a polymerization step of polymerizing a monomer in the presence of the microorganism to be detected to form a polymer layer having the microorganism incorporated therein on the detection electrode, and a disruption step of bringing at least a part of the microorganism incorporated in the polymer layer into contact with a solution containing a lytic enzyme to disrupt the microorganism.

Abstract: A sample assembly includes an outer layer with at least one sample trench. The sample trench includes a first set of antibodies that are bonded on a first surface of a base layer. Target antigens are bonded with the first set of antibodies, and a second set of antibodies are bonded to the target antigens. Further, the sample trench includes nanoparticles that are bonded to the second set of antibodies.

Abstract: A coplanar waveguide transmission line for use in detecting biomolecules and bioparticles is provided that includes a signal conductor disposed on a top surface of the dielectric substrate, a ground conductor disposed on the top surface of the dielectric substrate on each side of the signal conductor, a continuous gap defined between the signal conductor and each of the ground conductors, micro-channels disposed below a top surface of the dielectric substrate, and reservoirs disposed below the top surface of the substrate.

Abstract: An assay device for determining the concentration of multiple analytes or controls, where the device is capable of determining the presence or concentration of at least six analytes or controls includes: a fluid flow path; a liquid sample addition zone; a reagent zone downstream and in fluid communication with the sample addition zone containing one or more reagents; multiple detection zones in fluid communication with the reagent zone. The fluid flow path, which extends through the detection zones, has a length capable of having at least six detection zones linearly spaced at least a sufficient distance apart in order to discriminate each signal peak from its adjacent signal peak. The device further includes a wicking zone in fluid communication with the detection zones having a capacity to receive liquid sample flowing from the detection zone.

Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.

Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.

Abstract: The present disclosure provides recombinant phages, a Wip1 p23 receptor binding protein and a Wip1 p24 receptor binding protein that bind to Bacillus anthracis. The disclosure further provides methods and uses thereof.

Abstract: Methods and kits for assessing the presence of, and for detecting cancer, notably oral cancer, are disclosed. Such methods and kits use one or more lectins operably linked to a fluorophore, wherein the lectin binds differentially to cancerous and non-cancerous tissues, and wherein the fluorophore facilitates visualizing the differential binding. The lectins are applied to the oral mucosa of a subject, the fluorophore is exposed to light, and cancerous regions of the mucosa are visualized. In certain embodiments, the lectin specifically binds to one or more of a ?-galactoside, an ?- or ?-N-acetylglucosamine, or a sialic acid moiety.

Abstract: This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ASCL1 and RET expression levels to identify lung cancer patients having lung adenocarcinoma characterized by neuroendocrine differentiation are provided.