Patents Issued in February 4, 2016
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Publication number: 20160030589Abstract: Provided is a method for making the compound of Formula 1: Various compounds utilized in that method are also provided, as are methods of making those compounds. Also provided is a compound having the formula XO—CO—(CH2)nNH2, where n is an integer greater than 2. A method of making that compound is additionally provided. Further provided is a method of making a prodrug of a bioactive compound.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: Genspera, Inc.Inventors: John K Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
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Publication number: 20160030590Abstract: The disclosure provides for peptide-based bolaamphiphile vectors that are capable of encapsulating a variety of agents, including peptides, proteins, nucleic acids, and drugs. The disclosure further provides for delivering these agents across biological membranes using the peptide-based bolaamphiphile vectors.Type: ApplicationFiled: July 30, 2015Publication date: February 4, 2016Inventors: Zhibin Guan, Hanxiang Zeng, Mark Edward Johnson
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Publication number: 20160030591Abstract: The present disclosure relates to linker compounds that are useful in covalently linking biologically active molecules with Ligands. The disclosed compounds also relate to biologically active molecules and Ligand conjugates, wherein the biologically active molecule is linked to the Ligand through a linker. The disclosure further provides compositions comprising biologically active molecule-ligand conjugates, methods of modifying abnormal cell growth and methods of treatment using the conjugates or the compositions.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Inventor: Thomas NITTOLI
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Publication number: 20160030592Abstract: In the present disclosure, polymer conjugates, including polymer-antibody-drug conjugates (polymer ADCs) are described, as well as the use of such conjugates to treat human disease. The polymer conjugates can contain a large number of polymer-bound agents, thus effectively increasing the drug antibody ration (DAR) of the antibody significantly beyond the currently available technology. This may be of particular importance when antibodies to low density antigens are used as target antibodies. The described polymer-ADCs have improved pharmacokinetics and solubility relative to traditional ADCs. The linker between agent and the polymer can be tailored to provide release of toxin at the desired site and under the desired conditions within the tumor. An additional feature of the polymer-ADCs of the current disclosure is that a purification moiety can be attached to the polymer backbone to provide ease of purification of the polymer-ADCs.Type: ApplicationFiled: July 31, 2015Publication date: February 4, 2016Inventors: Randall W. MOREADITH, Michael D. Bentley, Zhihao Fang, Tacey Viegas
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Publication number: 20160030593Abstract: The present invention generally relates to an antibody composition including antibodies conjugated to nanoparticles. The antibody composition may be used in methods to treat drug use, drug addiction, and effects of drug use.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Applicant: Board of Trustees of the University of ArkansasInventors: Eric C. Peterson, Nisha Nanaware-Kharade, Guillermo Gonzalez III
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Publication number: 20160030594Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.Type: ApplicationFiled: March 12, 2014Publication date: February 4, 2016Inventors: Tinya ABRAMS, Steven COHEN, Christie P. FANTON, Catrin FINNER, Thomas HUBER, Kathy MILLER, Siew Ho SCHLEYER, Kathrin Ulrike TISSOT-DAGUETTE
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Publication number: 20160030595Abstract: Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed.Type: ApplicationFiled: October 9, 2015Publication date: February 4, 2016Inventors: Scott A. Waldman, Michael S. Magee, Adam E. Snook
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Publication number: 20160030596Abstract: Provided herein are various gas-filled particles having a stabilized membrane that encapsulates the gas. Pharmaceutical compositions, methods of use and treatment, and methods of preparation are also described.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: John Kheir, Brian D. Polizzotti
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Publication number: 20160030597Abstract: Isolated polynucleotides comprising a S100B mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: July 24, 2015Publication date: February 4, 2016Inventors: Elizabeth M. Simpson, Charles de Leeuw, Wyeth W. Wasserman, Daniel Goldowitz
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Publication number: 20160030598Abstract: Disclosed are compounds and methods useful in the detection of e.g., Zn2+, in vitro and in vivo. The compounds include amino acids and peptides functionalized with a moiety that binds, e.g., Zn2+. Importantly, the compounds do not exhibit substantial fluorescence in the absence of zinc.Type: ApplicationFiled: April 28, 2014Publication date: February 4, 2016Inventors: Robert J. Radford, Stephen J. Lippard, Wen Chyan
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Publication number: 20160030599Abstract: The present invention relates to particles, useful for drug release detection, comprising: at least one luminescent metal complex of formula [Ln].[L], wherein: Ln is a lanthanide ion, L is an organic ligand comprising a hydrophilic unit with at least 6 chelating groups chosen from the group consisting of hydroxyl, carboxyl, optionally in the carboxylate form, carbonyl, ether, phosphonate, phosphinate, thiolate, amino and imino functions, and at least one drug comprising a conjugated aromatic system, wherein said drug is not covalently bonded to the metal complex, said particle having a size comprised from 3 nm to 2000 nm, and wherein the distribution of the metal complex and the drug within the particle is such that the mean distance between a drug molecule and a metal complex is less than 15 nm.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Inventors: Eva Jakab Toth, Stéphane Petoud, Sara Lacerda, Célia Bonnet
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Publication number: 20160030600Abstract: This invention relates to nanoparticles for use in the in vivo diagnostics of epicardial derived cells (EPDCs) to nano particles for use in the treatment of cardiac injury. The invention further relates to a method for analyzing EPDCs, to a method for labeling EPDCs, and to a method for transferring a therapeutic agent into an EPDC.Type: ApplicationFiled: March 6, 2014Publication date: February 4, 2016Inventor: Juergen SCHRADER
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Publication number: 20160030601Abstract: A radiopaque composition is provided that includes an inorganic opacifying agent distributed through an aqueous gelatinous substance in an aqueous solvent. A process for making a radiodense vascular fill composition includes adding a gelatinous substance to an aqueous solution. An inorganic opacifying agent suspension is formed in a saline solution or water. The inorganic opacifying agent and gelatin are mixed with water or saline. A process of imaging a vascular system of a subject includes placing a subject under anesthesia or sedation and exsanguinating the subject. An isotonic fluid is then flushed through the vascular system and the radiopaque composition is infused into the subject circulatory system at a temperature of 40 degrees Celsius or greater. After waiting a given time interval for the radiopaque composition to cool and form a solid gel, an imaging scan is performed on the subject.Type: ApplicationFiled: August 26, 2015Publication date: February 4, 2016Inventor: Michael Scott Echols
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Publication number: 20160030602Abstract: This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Inventors: Matthew J. DREHER, Bradford J. WOOD, Ayele H. NEGUSSIE, Andrew Leonard LEWIS, Yiqing TANG
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Publication number: 20160030603Abstract: The invention provides a method of detecting acute renal allograft rejection in a subject as well as a method of stratifying a subject received a renal allograft and undergoing immunosuppressive therapy for alteration of the therapy. These methods comprise administering to the subject a probe capable of specifically binding to T lymphocytes, the probe being detectable by ultrasound. An allotransplanted kidney of the subject is exposed to ultrasound. The level of T lymphocytes in the kidney is detected. An elevated level of T lymphocytes in the kidney indicates an increased risk of renal allograft rejection and/or that the subject is in need of an alteration of the immunosuppressive therapy.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Inventors: Stefan Reuter, Klaus Tiemann
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Publication number: 20160030604Abstract: The invention provides compositions and methods for evaluating neuromuscular function in a subject, e.g., a subject at risk for or suffering from a neuromuscular disorder.Type: ApplicationFiled: March 12, 2014Publication date: February 4, 2016Applicant: BIOGEN MA INC.Inventors: Ajay Verma, Jack Hoppin
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Publication number: 20160030605Abstract: Compounds of Marlush formula (I) described in the claims are useful in diagnostic methods for detecting and/or identifying cells presenting PSMA. Disclosed are also methods for preparing the compounds.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Inventors: Clifford Berkman, Svetlana A. Stekhova
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Publication number: 20160030606Abstract: The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (VHH) or functional fragments thereof, wherein said VHH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g., HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions, for use in methods for the prevention and/or treatment of cancer.Type: ApplicationFiled: July 17, 2015Publication date: February 4, 2016Inventors: Nick Devoogdt, Jens De Vos, Matthias D'Huyvetter, Tony Lahoutte
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Publication number: 20160030607Abstract: A freezer apparatus for treating a product with cryogen includes a source of cryogen liquid and a source of cryogen gas; a first conduit for delivering a first amount of the cryogen liquid; a second conduit in fluid communication with the first conduit for delivering a second amount of the cryogen gas into the cryogen fluid for being mixed therewith to provide a cryogen mixture having a ratio selected of cryogen gas:cryogen liquid; and a delivery apparatus in fluid communication with the first conduit downstream of the second conduit, the delivery apparatus including at least one outlet through which the cryogen mixture passes for contacting a surface of the product. A related method is also provided.Type: ApplicationFiled: August 4, 2014Publication date: February 4, 2016Inventor: Michael D. Newman
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Publication number: 20160030608Abstract: Provided is an autoclave for sterilisation including a sterilisation chamber, a tank of water, connection means configured to connect the tank to the sterilisation chamber in a fluidic through connection, heating means configured to heat and to pressurise the water and to supply the sterilisation chamber to perform sterilisation cycles, in which the tank includes a filter, the tank is in addition divided into a high potential portion and a low potential portion, the portions being in reciprocal fluidic through connection through the filter, the filter comprising a plurality of filtering layers including distribution layers configured to slow down and improve the distribution of the water along the entire area of the layers and active layers configured to perform purification functions of the water.Type: ApplicationFiled: March 11, 2014Publication date: February 4, 2016Applicant: ABSOLUTE UP S.R.L.Inventors: Daniele Giovanni ONGARO, Maria Pia GHILARDI
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Publication number: 20160030609Abstract: Disclosed herein is a light fixture. The light fixture includes at least one first light source that emits at a peak wavelength in a range of approximately 380 nm to approximately 420 nm and at least one second light source that emits at a different peak wavelength, wherein a combined light output of the at least one first light source and the at least one second light source emits a colored light that is perceived as white light. The white light is defined by having a color rendering index (CRI) value of more than approximately 50. The at least one second light source that emits at a different peak wavelength consists of an xy coordinate on a International Commission on Illumination (CIE) 1931 xy color space diagram above a black body curve within a bounded area defined by a first line of approximately y=2.23989x?0.382773 and a second line of approximately y=1.1551x?0.195082.Type: ApplicationFiled: July 29, 2015Publication date: February 4, 2016Inventors: James W. Peterson, Jorel Lalicki
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Publication number: 20160030610Abstract: Disclosed herein is a light fixture. The light fixture includes at least one first light source that emits at a peak wavelength in a range of approximately 380 nm to approximately 420 nm and at least one second light source that emits at a different peak wavelength, wherein a combined light output of the at least one first light source and the at least one second light source emits a colored light that is perceived as white light. The white light is defined by having a color rendering index (CRI) value of more than approximately 50. The at least one second light source that emits at a different peak wavelength consists of an xy coordinate on a International Commission on Illumination (CIE) 1931 xy color space diagram above a black body curve within a bounded area defined by a first line of approximately y=2.23989x?0.382773 and a second line of approximately y=1.1551x?0.195082.Type: ApplicationFiled: September 30, 2014Publication date: February 4, 2016Inventors: James W. Peterson, Jorel Lalicki
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Publication number: 20160030611Abstract: A processing unit and method for separating hydrocarbons from feedstock material. The processing unit includes at least one rotating conveyor in communication with a material inlet and a material outlet; a vacuum pump providing a vacuum atmosphere within the rotating conveyor; at least one material transfer device positioned at the material inlet and at least one material transfer device positioned at the material outlet, each material transfer device configured to allow transfer of feedstock material into or out of the rotating conveyor whilst maintaining the vacuum atmosphere within the rotating conveyor; and an electrostatic generator connected to the rotating conveyor providing a static charge to the vacuum atmosphere within the rotating conveyor.Type: ApplicationFiled: April 25, 2013Publication date: February 4, 2016Inventor: Phillip Cauley
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Publication number: 20160030612Abstract: A mobile phone charger with a sterilization UV LED may include: a charger case having a space formed therein and including a mobile phone stand formed at the front surface thereof; and one or more first UV LEDs installed at one side of the space of the charger case.Type: ApplicationFiled: February 26, 2014Publication date: February 4, 2016Applicant: SEOUL VIOSYS CO., LTD.Inventors: Jong Rack Kim, Dae Wong Suh, Seong Min Lee, Ik Hwan Ko
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Publication number: 20160030613Abstract: Devices, methods and systems of disinfecting medical instruments, more particularly blood glucose meters. A disinfection cradle including a flat base for positioning the cradle on a surface, the cradle having a receptacle configured to receive the diagnostic apparatus, and a UV source positioned in the receptacle that is configured to administer a disinfection cycle to the diagnostic apparatus by directing UV light outward at the diagnostic apparatus received in the receptacle, the UV light being able to act as a disinfecting agent to the disinfection cradle and diagnostic apparatus.Type: ApplicationFiled: July 30, 2015Publication date: February 4, 2016Inventors: Patrick J. Paul, Edward David Arguello, Brent E. Modzelewski
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Publication number: 20160030614Abstract: Antiseptic compositions comprising at least one salt of EDTA are disclosed. These compositions have broad spectrum antimicrobial and antifungal activity and they also have anticoagulant properties. The antiseptic compositions have also demonstrated activity in penetrating and breaking down microbial slime, or biofilms. They are safe for human and medical uses and may be used as prophylactic preparations to prevent infection, or to reduce the proliferation of and/or eliminate existing or established infections.Type: ApplicationFiled: September 4, 2015Publication date: February 4, 2016Inventors: Peter Kite, David Hatton
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Publication number: 20160030615Abstract: Device (10, 110) for evaporating a liquid, including: a reservoir (14) containing the liquid; an organ for absorbing the liquid (16); and an organ for producing a gas flow (18), which is directed towards the absorption organ (16); characterised in that the absorption organ (16) comprises a plurality of absorbent strips (24) suited to retain the liquid.Type: ApplicationFiled: October 9, 2015Publication date: February 4, 2016Inventor: Alberto SARDO
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Publication number: 20160030616Abstract: The present invention provides an incubator hood having a hydrophilized portion on at least a part of its inner surface, the hydrophilized portion containing a hydrophilic polymer and an antibacterial agent, and a surface of the hydrophilized portion having a water contact angle of up to 30°, and also provides an incubator having the incubator hood as well as a hydrophilic sheet and a hydrophilic antibacterial film for use in forming the hydrophilized portion on the incubator hood. Thus the present invention provides an incubator hood, an incubator, a hydrophilic sheet and a hydrophilic antibacterial film that have excellent antifogging properties and antibacterial properties and can suppress the growth of bacteria.Type: ApplicationFiled: July 28, 2015Publication date: February 4, 2016Applicant: FUJIFILM CorporationInventors: Fumito NARIYUKI, Toshiyuki NABETA, Michihiro SHIBATA, Hideo NAGASAKI, Setsuko SHIRATSUCHI, Shigeaki OHTANI
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Publication number: 20160030617Abstract: A sterilization container includes a floor. A first sidewall is connected to a first side of the floor and a second sidewall is connected to a second side of the floor wherein each of the first and second sidewalls has an elongated blind cavity formed along a length thereof. A first hinge is positioned partially within the blind cavity of the first sidewall, and a second hinge is positioned partially within the blind cavity of the second sidewall, wherein each of the first and second hinges are movable along a length of the first and second blind cavities, respectively. A lid is connected between the first and second hinges and is positionable between a first position substantially parallel with the floor on a third side of the floor, and a second position substantially parallel with the floor on a fourth side of the floor.Type: ApplicationFiled: July 29, 2014Publication date: February 4, 2016Inventors: Jason Hawkes, Robert Zeuge
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Publication number: 20160030618Abstract: A preventative solution includes an aqueous base, 1 wt % to 6 wt % titanium dioxide having an average particle size of not greater than 100 nm, 0.5 wt % to 20 wt % alcohol having 2 to 4 carbons, and 3 wt % to 15 wt % of a binding agent. The preventative solution can be dispersed using a fogger, for example, sequentially with an odor neutralizing solution or a disinfectant solution.Type: ApplicationFiled: August 10, 2015Publication date: February 4, 2016Inventors: Babak R. Samani, Morey E. Osbourn
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Publication number: 20160030619Abstract: A fruit and clove pomander kit for efficiently creating a pomander using fruit and cloves. The fruit and clove pomander kit includes a carving and piercing tool having a piercing end adapted to create pierced holes within a fruit and a carving end opposite of the piercing end. The kit further includes a plurality of dried cloves, a rubber band, a writing instrument and at least one hanger hook. The hanger hook is comprised of a helical portion, an engaging portion extending upwardly from the helical portion and an end portion extending downwardly from the helical portion opposite of the engaging portion. The end user uses the kit to create a pomander with a piece of fruit.Type: ApplicationFiled: June 29, 2015Publication date: February 4, 2016Inventor: Teresa Maureen Clark
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Publication number: 20160030620Abstract: Automated air freshener dispensers and cartridges therefor are provided herein. Air freshener dispensers include a housing having a cavity for receiving a cartridge containing an air freshening substance for release, a fan that induces an airflow through the housing and directs the airflow to an area outside of the air freshener dispenser, such that released air freshening substance is entrained in the airflow, a motor for driving the fan, at least one sensor, and a controller that receives a signal from the at least one sensor and directs operation of the fan in response thereto.Type: ApplicationFiled: July 29, 2015Publication date: February 4, 2016Applicant: GEORGIA-PACIFIC CONSUMER PRODUCTS LPInventors: Eric Paul Peterson, Todd Richard Lappi, Daniel M. D'Amico
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Publication number: 20160030621Abstract: A method and system of controlling operation of a diffusion appliance to treat the atmosphere within an enclosed space. The appliance may be programmed to operate according to a control scheme specifying a flow rate of liquid to a diffusion means and a periodic operation of the diffusion means. Control schemes may be associated with different volumes of spaces to be treated by the appliance. Anti-fatigue schemes may provide variation of the flow rate or periodic operation of the appliance. Initiation controls schemes may be used to start treatment of the space before the appliance is programmed to operate according to one of the control schemes.Type: ApplicationFiled: April 3, 2015Publication date: February 4, 2016Inventors: Richard Weening, Marc Robert
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Publication number: 20160030622Abstract: The present invention relates to an air purification system with plasma driven catalyst technology. The system comprises a plurality of plasma driven catalyst reactors in a parallel setup. Zigzag electrodes comprising zigzag structures are used to facilitate plasma generation. The system of the present invention provides the advantages with ease of fabrication and scaling-up, and improvement of air purification performance.Type: ApplicationFiled: January 9, 2015Publication date: February 4, 2016Inventors: Jifan LI, Lei WANG, Ka Chun LEE, Wai Yan CHAN
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Publication number: 20160030623Abstract: An absorbent layer for moderating blood flow from a wound has a non-woven fabric layer of water-insoluble chitosan fibers having a coating of water-absorbent starch on at least one face of the fabric layer. The coating of water-absorbent starch penetrates into the fabric layer from a first surface over the chitosan fibers to a depth of at least 25% of the fabric layer of chitosan fibers. The chitosan fibers have average diameters of from 5 to 30 micrometers. The average weight of starch/chitosan may decrease from the first surface from which the starch has penetrated into the fabric to the depth of at least 50% of the fabric layer. The starch may be modified to include hydrophilic groups into or onto molecular chains of the starch.Type: ApplicationFiled: August 4, 2014Publication date: February 4, 2016Inventor: James F. Drake
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Publication number: 20160030624Abstract: The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polyelectrolytes to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.Type: ApplicationFiled: October 14, 2015Publication date: February 4, 2016Inventors: Nicholas L. Abbott, Ankit Agarwal, Christopher J. Murphy, Jonathan F. McAnulty
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Publication number: 20160030625Abstract: Porous polymer composites and methods of preparing porous polymer composites are provided herein. In some embodiments, a method for preparing porous polymer composites may include mixing a first polymer with a solvent and a particulate filler to form a first polymer composition, wherein the amount of particulate filler in the first polymer composition is below a mechanical percolation threshold; and removing the solvent from the first polymer composition to concentrate the first polymer and particulate filler into a second polymer composition having a porous structure, wherein the particulate filler concentration in the second polymer composition is increased above the mechanical percolation threshold during solvent removal.Type: ApplicationFiled: July 29, 2014Publication date: February 4, 2016Inventors: Randy A. Mrozek, Joseph L. Lenhart, Michael C. Berg, Eric J. Robinette
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Publication number: 20160030626Abstract: Rapid setting high strength calcium phosphate cements and methods of using the same are provided. Aspects of the cements include fine and coarse calcium phosphate particulate reactants and a cyclodextrin which, upon combination with a setting fluid, produce a flowable composition that rapidly sets into a high strength product. The flowable compositions find use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.Type: ApplicationFiled: August 4, 2015Publication date: February 4, 2016Inventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
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Publication number: 20160030627Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.Type: ApplicationFiled: October 9, 2015Publication date: February 4, 2016Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, JUNSEI EDUCATIONAL INSTITUTIONInventors: Yasuhiro YOSHIDA, Masato TANAKA, Kazuomi SUZUKI, Toshifumi OZAKI, Tomohiro TAKAHATA, Masao IRIE, Mariko NAKAMURA, Mitsunobu KAWASHIMA, Yamato NOJIRI, Koichi OKADA, Masahiro NAGAO
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Publication number: 20160030628Abstract: Materials and methods for treating bile leakage are disclosed. A peptide comprising between about 7 amino acids to about 32 amino acids may be introduced to a target site. The peptide may undergo self-assembly upon adjustment of a pH level of the solution to a physiological pH level.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Applicant: 3-D MATRIX, LTD.Inventor: Satoru Kobayashi
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Publication number: 20160030629Abstract: Peptide-albumin hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and albumin. The peptide comprises a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.Type: ApplicationFiled: December 6, 2013Publication date: February 4, 2016Inventors: Xiuzhi S. Sun, Hongzhou Huang, Thu Annelise Nguyen
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Publication number: 20160030630Abstract: The present invention relates generally to methods and related kit to maximize the effectiveness of anti-fungus medicines including Vicks Vapor Rub and to mitigate the spread of infection to other toes or fingers and to other people. The kit consists of part of disposable nitrile glove or the like, anti-fungus medicine such as topical drug, and a tape. Barrier-inverting method and rolling-up method have been disclosed on how to apply the kit to the infected areas.Type: ApplicationFiled: July 30, 2014Publication date: February 4, 2016Inventor: Scot Douglas Kingsbury
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Publication number: 20160030631Abstract: Bone filler compositions, methods of making and using the same, and methods of treating osteoporosis and cancer-induced bone defects, are described.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Applicant: THE UNIVERSITY OF TOLEDOInventors: Anand K. Agarwal, Vijay K. Goel, Dong-Shik Kim, Sarit B. Bhaduri, Boren Lin
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Publication number: 20160030632Abstract: Described is a medical implant having a CoCr cast body and a commercially pure (CP) Ti coating. The CP Ti coating is diffusion bonded to the CoCr body and is 5-3000 ?m thick. Also described is a process for producing the medical implant that includes preparing the cast CoCr body for coating, applying a coating using a cold spray process, and diffusion bonding the coating to the body using hot isostatic pressing.Type: ApplicationFiled: March 5, 2013Publication date: February 4, 2016Inventors: John Schleicher, James K. Barrett, James Ault
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Publication number: 20160030633Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.Type: ApplicationFiled: July 20, 2015Publication date: February 4, 2016Applicant: MIMEDX GROUP, INC.Inventors: John Daniel, Randall Spencer, John Russo, Robert Tofe
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Publication number: 20160030634Abstract: A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.Type: ApplicationFiled: October 13, 2015Publication date: February 4, 2016Applicant: Mimedx Group, Inc.Inventor: John Daniel
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Publication number: 20160030635Abstract: Provided herein are methods of producing extracellular matrix (ECM) that are superior to previously-described methods. Extracellular matrix (ECM) comprises protein that forms many structures in the body including tendons, ligaments, and sheets that support skin and internal organs. There remains a need in the art for ECM compositions that have improved cell attachment characteristics and methods of making such ECM compositions.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: ANTHROGENESIS CORPORATIONInventors: Mohit B. Bhatia, Aleksandr Kaplunovsky, Xuan Guo
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Publication number: 20160030636Abstract: The subject invention pertains to materials and methods for processing tissue to produce a natural, acellular replacement tissue that is immunocompatible with a recipient. According to the subject invention, harvested tissue is subjected to wash solutions wherein only amphoteric detergent(s) are used (e.g., anionic detergents are excluded). Following extraction by amphoteric detergent(s), the tissue is washed with a buffer system to facilitate the clearance of cellular components and detergent. In one embodiment, the subject invention pertains to a replacement tissue that is a nerve graft that supports axonal regeneration, guides axons toward the distal nerve end and/or is immunologically tolerated. Preferably, the nerve graft retains essential extracellular matrix scaffolding as well as biological components that promote nerve regeneration through the nerve graft.Type: ApplicationFiled: March 17, 2014Publication date: February 4, 2016Inventor: David F. MUIR
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Publication number: 20160030637Abstract: The invention provides a method for maintaining capillary lumen diameter, reducing a decrease in capillary vessel lumen diameter or expanding capillary vessel lumen diameter in a re-endothelialized decellularized organ or tissue graft with an intact extracellular matrix vascular network. The method is based on administration of endothelial cells and microparticles to the decellularized ECM.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Inventors: Jeffrey Ross, Dominique Seetapun
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Publication number: 20160030638Abstract: The invention provides a method for preparing a perfusion based islet cell containing extracellular matrix of liver, an islet cell recellularized extracellular matrix, and methods of using the recellularized matrix.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Inventor: Jeffrey Ross