Patents Issued in February 4, 2016
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Publication number: 20160030639Abstract: There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose tissue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.Type: ApplicationFiled: October 12, 2015Publication date: February 4, 2016Applicant: ALLOSOURCEInventor: Yaling Shi
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Publication number: 20160030640Abstract: The present invention relates to a novel composition comprising carbon nanotubes and/or graphene and a supporting material that can be used as an implant, patch or construct for the treatment, repair or replacement of biological tissue, including musculoskeletal tissue, fascia tissue, dura tissue, epidermal tissue, blood vessels and arteries, and organs. The present invention is also a method of manufacturing the novel composition, and a method of using the novel composition to treat, repair or replace biological tissue.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Inventors: Joshua Schroeder, Colin Nuckolls, Frank P. Cammisa, Jr., Celeste Abjornson, Bumjung Kim
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Publication number: 20160030641Abstract: A method of preparing a mixed-phase thermoplastic biomaterial comprises contacting and reacting a diol and a graft pre-polymer comprising a diol and at least one covalently bonded unsaturated monomer with an organic diisocyanate compound. The reaction is conducted within an aprotic solvent and for a period of time and at a temperature sufficient to produce the mixed-phase thermoplastic biomaterial. The diol may be selected from the group consisting of siloxane diols, polyether diols, polyester diols and polycarbonate diols while the at least one covalently bonded unsaturated monomer may be selected from the group consisting of a fluorinated monomer, a siloxane monomer, an aliphatic ester of methacrylic acid, a cyclic ester of methacrylic acid, a charged monomer, a sulfonium salt, a vinyl monomer with phenol or benzoic acid, N-vinyl pyrrolidone, an aminoglucoside, and a therapeutic agent. The mixed-phase thermoplastic biomaterial may further include an anti-microbial, a therapeutic agent or both.Type: ApplicationFiled: July 30, 2015Publication date: February 4, 2016Applicant: Proton Innovations, LLCInventor: James A. Bonafini, JR.
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Publication number: 20160030642Abstract: This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating.Type: ApplicationFiled: October 9, 2015Publication date: February 4, 2016Inventors: Bin Huang, David C. Gale, Daniel A. Castro, Vincent J. Gueriguian
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Publication number: 20160030643Abstract: Provided herein is a coated coronary stent including a stent framework, heparin molecules attached to the stent framework and a rapamycin-polymer coating wherein at least part of rapamycin is a crystalline form. In one embodiment, the rapamycin-polymer coating comprises one or more resorbable polymers. Methods for preparing stents are also disclosed.Type: ApplicationFiled: May 21, 2015Publication date: February 4, 2016Applicant: MICELL TECHNOLOGIES, INC.Inventor: James B. McClain
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Publication number: 20160030644Abstract: A stent that includes a stent body and one or more weld joints, wherein the weld joints include a radiopaque material, and a method of making a stent that includes using a radiopaque filler material in a welding process.Type: ApplicationFiled: July 30, 2014Publication date: February 4, 2016Inventor: Syamala Rani Pulugurtha
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Publication number: 20160030645Abstract: Systems, method, and devices are disclosed that involve reconfiguring lumens or unblocking lumens relative to a blockage to maintain flow of reduced pressure to a subcutaneous tissue site. In one instance, a multi-lumen applicator includes an applicator body having a distal end and a proximal end and formed with a plurality of apertures for receiving fluid from the tissue site and for delivering reduced pressure, a first lumen fluidly coupled to the plurality of apertures, a first activation member having at least a closed position and a open position, and a second lumen fluidly coupled to the plurality of apertures but for the first activation member being in closed position. The configuration is such that when the first activation member is moved to the open position, the second lumen is fluidly coupled to the plurality of apertures. Other systems, methods, and devices are disclosed.Type: ApplicationFiled: October 9, 2015Publication date: February 4, 2016Inventors: Jonathan KAGAN, Douglas A. CORNET
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Publication number: 20160030646Abstract: Apparatuses and methods disclosed herein relate to various embodiments of wound fillers that, in some cases, preferentially collapse in one direction as compared to another direction. Such apparatuses and methods may aid in the closure of wounds and may further be used in combination with pressure sensors and controllers to provide for controlled collapse of the wound fillers.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Inventors: Edward Yerbury Hartwell, John Kenneth Hicks, Carl Saxby, Elizabeth Mary Huddleston, John Christian Hoggarth, Tim Stern, Andrew Linton
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Publication number: 20160030647Abstract: A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein.Type: ApplicationFiled: October 12, 2015Publication date: February 4, 2016Inventor: F. Nicholas Franano
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Publication number: 20160030648Abstract: A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein.Type: ApplicationFiled: October 12, 2015Publication date: February 4, 2016Inventor: F. Nicholas Franano
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Publication number: 20160030649Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.Type: ApplicationFiled: March 5, 2014Publication date: February 4, 2016Applicant: THORATEC CORPORATIONInventor: Zijing Zeng
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Publication number: 20160030650Abstract: A TET system is operable to vary an amount of power transmitted from an external power supply to an implantable power unit in accordance with a monitored condition of the implantable power unit. The amount of power supplied to the implantable power unit for operating a pump, for example, can be varied in accordance with a cardiac cycle, so as to maintain the monitored condition in the power circuit within a desired range throughout the cardiac cycle.Type: ApplicationFiled: October 15, 2015Publication date: February 4, 2016Inventors: Barry M. Yomtov, John Robert Batty
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Publication number: 20160030651Abstract: An implantable device for improving the pump function of the heart of a human patient by applying an external force on the heart muscle is disclosed. The device includes at least one pump device having a pump. The pump includes: a piston adapted for reciprocating movement, an operating device for operating the piston, and a heart contacting organ. The movement of the piston assists the pump function of the heart through the heart contacting organ.Type: ApplicationFiled: April 13, 2015Publication date: February 4, 2016Inventor: Peter Forsell
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Publication number: 20160030652Abstract: An implantable cable connection device is provided with a cable connector which can comprise several plug-in connection elements, to which in each case an implantable cable can be connected by way of a plug-in connection, where the cable connector is designed as a rigid body of a biocompatible material.Type: ApplicationFiled: April 4, 2014Publication date: February 4, 2016Inventors: Andreas ARNDT, Peter NÜSSER, Kim Peter WINTERWERBER
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Publication number: 20160030653Abstract: A system and method for determining a concentration of total chlorine in dialysis water are provided. The system comprises a main unit housing an iodide/water sample chamber and a reducing agent chamber. An electrode pair bridges the two chambers and generates tri-iodide proportional to the amount of total chlorine in the dialysis water. The electrode pair detects the amount of tri-iodide generated in proportion to the amount of active chloride in the dialysis water. The system is suitable for use in connection with, or for incorporation into, a water purification system for generating dialysis fluid, and may include a display that alerts the user to stop or prevent a hemodialysis treatment if the total chlorine level exceeds a predetermined level.Type: ApplicationFiled: September 25, 2015Publication date: February 4, 2016Inventors: Jeff White, Ye Chen, Yuanpang Samuel Ding, Joel Titus, Justin Rohde, Shincy Maliekkal, Kevin Cooper
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Publication number: 20160030654Abstract: In some aspects, a dialysis machine support assembly includes a platform configured to support a dialysis machine and a drive assembly configured to move the platform vertically.Type: ApplicationFiled: October 14, 2015Publication date: February 4, 2016Inventors: Gurpreet Singh, Sean Farrell, Michael David Young
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Publication number: 20160030655Abstract: This disclosure relates to detecting fluid in medical tubing. In certain aspects, a method is performed by a data processing apparatus. The method includes controlling repetitive activation of the ultrasonic transmitter. The method also includes receiving a signal from the ultrasonic receiver during an activation of the ultrasonic transmitter. The method also includes determining that fluid is absent or present in a portion of the medical fluid tube based on a comparison between the signal and a threshold value.Type: ApplicationFiled: October 9, 2015Publication date: February 4, 2016Inventors: Nigel Wright, Samuel Ernest Magargi, III, Jeremy Thomas Harbaugh, Michael John Zang, Regis Joseph Winniewicz, JR., Joseph Stephen Beri, Douglas Mark Zatezalo, Tom Monahan, Ronald Robert Fox
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Publication number: 20160030656Abstract: Disclosed is an anti-contamination device for preventing contamination of a fluid stored in a fluid container with a spike and a manually operable fluid blocking mechanism arranged directly downstream of the spike. A non-return valve is arranged between the spike and the fluid blocking mechanism, and that valve is adapted to allow only a flow from the spike in the direction of the manually operable fluid blocking mechanism.Type: ApplicationFiled: April 16, 2014Publication date: February 4, 2016Inventors: GUIDO EIKELMANN, RAINER HECTOR
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Publication number: 20160030657Abstract: A dialysis system includes an extracorporeal circuit, a dialysis fluid circuit including first and second balance chambers, a fresh dialysis fluid pump in fluid communication with first and second fresh compartments of the first and second balance chambers, respectively. The first and second fresh compartments are in fluid communication with a fresh dialysate fluid inlet of the dialyzer, and a used dialysis fluid pump is in fluid communication with first and second spent compartments of the first and second balance chambers, respectively. The system is configured to run a blood rinseback sequence in which (i) at least one of the fresh used dialysis fluid pumps is operated to pump dialysis fluid through the dialyzer and into the extracorporeal circuit and (ii) the blood pump is operated to push blood back to a patient connected to the extracorporeal circuit.Type: ApplicationFiled: September 3, 2015Publication date: February 4, 2016Inventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed M. El Sayyid, Shahid Din
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Publication number: 20160030658Abstract: A system for detecting whether a vascular access has been interrupted in an arrangement in which two catheters or needles are present in a blood vessel, fistula or graft. A fluid line leading to a pump is connected via a first connector to a first indwelling catheter, and a fluid line leading from a pump is connected via a second connector to a second indwelling catheter. Each connector is equipped with an electrode in contact with the lumen of the connector, the electrodes electrically connected to an electronic circuit that measures the impedance or conductivity of fluid between the first connector and second connectors via a fluid path through the blood vessel, fistula or graft. An electronic controller receives the impedance or conductivity data and processes the data to determine whether a vascular access disconnection has occurred.Type: ApplicationFiled: May 27, 2015Publication date: February 4, 2016Inventors: Dirk A. van der Merwe, Michael G. Norris, Michael A. Baker, Todd A. Ballantyne, Michael J. Wilt
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Publication number: 20160030659Abstract: The present disclosure relates to methods of removing soluble NKG2D ligands, including soluble MICA, soluble MICB and soluble ULBP proteins, from blood to treat diseases characterized by abnormal levels of soluble NKG2D ligands. Further provided are systems and devices for carrying out the therapeutic methods.Type: ApplicationFiled: March 15, 2014Publication date: February 4, 2016Inventor: IAN WAYNE CHENEY
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Publication number: 20160030660Abstract: The present disclosure describes a system and method for microfluidic separation. More particularly, the disclosure describes a system and method for the purification of a fluid by the removal of undesired particles. The device includes microfluidic separation channels that include multiple outlets. The device also includes isolation slots positioned between each of the microfluidic separation channels. The device's base includes multiple acoustic transducers which in some implementations are configured to protrude into the isolation slots. The acoustic transducers are configured to generate aggregation axes within the separation channels, which are used to separate out undesired particles.Type: ApplicationFiled: July 31, 2015Publication date: February 4, 2016Inventors: Hoi-Cheong Steve Sun, Jason Oliver Fiering
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Publication number: 20160030661Abstract: The present invention relates to a blood separation container for extracting self-platelet. According to the present invention, since a second coupling portion is formed at a release prevention member coupled to a lower portion of a main body in a PRP separation container, and an ascending member having a bolt structure is screwed to the second coupling portion to ascend a lower cover disposed in a lower fluid chamber of the main body, a separate second main body is unnecessary unlike the related art. Therefore, the PRP separation container is easy to carry, manufacturing costs can be reduced to thereby ensure competitive price, and a PRP can be easily separated and extracted.Type: ApplicationFiled: October 8, 2015Publication date: February 4, 2016Applicant: GOOD MORNING BIO CO., LTD.Inventor: Eui Jae HWANG
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Publication number: 20160030662Abstract: A configurable fluid delivery system and methods for its use are disclosed. The system may include one or more control units, fluid delivery units, fluid actuator units, and disposable units. Data sources and sensors on each of the delivery units, actuator units, and disposable units may provide data to the control unit, thereby identifying the components along with the manner in which they may be configured. The control unit may notify a user regarding the status of any one or more of the delivery, actuator, and disposable units to indicate their appropriateness for delivering a fluid according to one or more selected procedures and protocols. Also disclosed are methods by which the configurable fluid delivery system may provide data to a user to assist the user in assembling and testing a particular configuration of the fluid delivery system for a specific use.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: BAYER MEDICAL CARE INC.Inventors: ARTHUR E. UBER, III, MARK TROCKI
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Publication number: 20160030663Abstract: Method and system for controllably administering and/or withdrawing fluid from a patient. In one embodiment, the system may include a needle assembly, an ultrasound imager, a fluid supply storage unit, a waste storage unit, a fluid pump, and a foot pedal assembly. A syringe may serve as the fluid supply storage unit and the waste storage unit. The pump may include a bi-directional motor and a gear coupled to the motor. The gear may be engageable with a rack on the syringe plunger to drive the plunger either for fluid aspiration or infusion. Depression of one portion of the foot pedal assembly causes the motor to drive the gear in one direction, and depression of another portion of the foot pedal assembly causes the motor to drive the gear the other direction. The system may include a control device to keep pressure in the fluid path from exceeding a limit.Type: ApplicationFiled: March 17, 2014Publication date: February 4, 2016Inventors: George Adaniya, Howard Donnelly, Eric Mathews, Hayden Taylor, Andrew Whitehead
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Publication number: 20160030664Abstract: A portable therapeutic fluid delivery device and a method for delivering a therapeutic fluid into a body of a patient are provided. In one aspect the therapeutic fluid delivery device and the method can be implemented using at least one housing securable to the body of the patient, a reservoir coupled to the at least one housing, a therapeutic fluid dispensing mechanism, a memory component, a controller, at least one bolus delivery button configured to signal the controller to initiate the delivery of the therapeutic fluid into the body of the patient; and, an inadvertent initiation prevention mechanism adapted for preventing the patient from activating the at least one bolus delivery button.Type: ApplicationFiled: October 15, 2015Publication date: February 4, 2016Inventors: Ofer Yodfat, Danna Perlman
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Publication number: 20160030665Abstract: A cartridge interface assembly (80) characterized by a driving plunger (82) including an outer shaft (84), and a driver (86) including an inner shaft (88) moveable telescopically with respect to the outer shaft (84), wherein rotation of the driver (86) causes the driving plunger (82) to advance in a direction away from the driver (86), and wherein the cartridge interface assembly (80) is inserted in a cartridge (22) in which a plunger (24) is slidingly disposed, and rotation of the driver (86) causes the driving plunger (82) to advance distally in the cartridge (22) until abutting against the plunger (24).Type: ApplicationFiled: October 12, 2015Publication date: February 4, 2016Applicant: MEDIMOP MEDICAL PROJECTS LTD.Inventor: Oz CABIRI
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Publication number: 20160030666Abstract: The present invention involves a method and a system for using electrical stimulation and/or chemical stimulation to treat a cognitive impairment and/or disorder. More particularly, the method comprises surgically implanting an electrode and/or catheter that is in communication with a predetermined site which is coupled to a pulse generating source and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the cognitive disorder and/or enhancing the cognitive ability.Type: ApplicationFiled: December 30, 2014Publication date: February 4, 2016Applicant: Functional Neuromodulation, Inc.Inventors: Andres M. Lozano, Helen S. Mayberg
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Publication number: 20160030667Abstract: An insertion device for an infusion set includes an advancement unit or a sliding element for moving the infusion set along a central axis from a proximal position into a distal position, a retaining element for retaining the infusion set that includes a guide element, a base part for accommodating the retaining element that includes a mating guide element and a contact surface for placing the insertion device on an application point of a patient's body, and a head part arranged rotatably about a central axis in relation to the base part. Upon relative rotation between the head part and the base part in one direction, the guide element of the retaining element can be guided with the mating guide element provided on the base part such that the retaining element is movable along the central axis relative to the base part from the distal position into the proximal position.Type: ApplicationFiled: July 28, 2015Publication date: February 4, 2016Inventors: Jürg Hirschel, Mario Bernhard
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Publication number: 20160030668Abstract: A method of infusing a fluid includes receiving values of one or more infusion parameters for an infusion of a fluid, Based on the received infusion parameter values, an occlusion pressure threshold for the infusion of the fluid is automatically calculated. During the infusion, a fluid pressure value is sensed. An indication is provided responsive to whether a value of the sensed fluid pressure is greater than the occlusion pressure threshold.Type: ApplicationFiled: October 13, 2015Publication date: February 4, 2016Inventors: Erik BARNES, Robert Dwaine BUTTERFIELD
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Publication number: 20160030669Abstract: A portable infusion pump can communicate with continuous glucose monitor (CGM) to receive continuous feedback relating to a user's blood glucose level during insulin or other medicament therapy and can automatically deliver insulin to a user when the CGM data indicates a need for additional insulin. Because patient behavior can interfere with the accuracy and efficacy of such closed loop or semi-closed loop therapy, a system can employ various mechanisms for manual temporary suspension of closed-loop therapy when a patient is aware that current or future behavior may inhibit therapy.Type: ApplicationFiled: July 30, 2015Publication date: February 4, 2016Inventors: Paul Harris, David Berger
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Publication number: 20160030670Abstract: Embodiments of the invention provide a system and method for administering a pharmaceutical to an individual through a dispenser control system. Input data is acquired from an input device coupled to a controller of the dispenser control system. The controller is in communication with the input device and configured to execute a stored program to calibrate pump settings of the dispenser control system based on the acquired input data. The stored program also computes a delivery schedule based on the pump settings for the individual and activates the dispenser control system to deliver at least one dose of the pharmaceutical according to the delivery schedule. The delivery schedule is characterized by a waveform other than a square-wave.Type: ApplicationFiled: July 31, 2015Publication date: February 4, 2016Inventor: Bruce Fischl
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Publication number: 20160030671Abstract: A multi-chamber injection device includes multiple syringes. The multiple syringes may be arrayed in a circular, linear, or other format. In some implementations, a needle, port, or similar may be shared by all the syringes in configuration that allows only one syringe to deliver contents at a time while blocking the other syringes from delivering their respective contents. In some implementations, the syringes may be all stored in the same container. One or more of the chambers of a multi-chamber injection device may be preloaded with medication. Different medications may be loaded into different chambers. The medications may be selected to treat the same medical condition.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Inventors: Patrick O. Tennican, L. Myles Phipps
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Publication number: 20160030672Abstract: The present invention inter alia relates to an apparatus. The apparatus comprises a body part, wherein the body part is made from a cyclic olefin polymer material or a cyclic olefin copolymer material or a mixture therefrom, and a diaphragm valve with a diaphragm, wherein at least a surface portion of the diaphragm is made from a diaphragm material, wherein said diaphragm material is a fluoroelastomer material or a perfluoroelastomer material or a mixture therefrom.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Inventors: Markus Manderscheid, James Alexander Davies
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Publication number: 20160030673Abstract: An apparatus for measuring liquid volume in a container includes a plurality of light sources for emitting electromagnetic radiation (EMR) toward the container, a plurality of sensors optically coupleable to the plurality of light sources, each sensor of the plurality of sensors for detecting the EMR emitted by at least a portion of the plurality of light sources, a temperature sensor for measuring at least one temperature associated with a liquid in the container, and at least one processor for receiving data representative of the portion of the detected EMR from each of the plurality of sensors, comparing the at least one measured temperature to a temperature guideline to identify any temperature events associated with the received data; normalizing the received data based on any temperature events associated with the received data; and converting the normalized data into a signature representative of the EMR detected by the plurality of sensors.Type: ApplicationFiled: August 3, 2015Publication date: February 4, 2016Inventors: James White, Richard Whalley, Kevin Sihlanick, Matthew Legrand
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Publication number: 20160030674Abstract: Various syringe systems are disclosed. One such syringe system may include a body having a hollow lumen and a distal end, a vacuum chamber disposed within the hollow lumen of the syringe body, a first plunger connected to a distal portion of the vacuum chamber, the first plunger forming a first seal against an inner surface of the syringe body and defining a fluid volume between the first plunger and the distal end of the syringe body, a second plunger disposed within the vacuum chamber, the second plunger forming a second seal against an inner surface of the vacuum chamber and defining proximal and distal volume compartments within the vacuum chamber, and a piston affixed to the second plunger, the piston configured to move the second plunger within the vacuum chamber, thereby altering a volume of the proximal volume compartment and a volume of the distal volume compartment.Type: ApplicationFiled: March 11, 2014Publication date: February 4, 2016Inventors: KEVIN P. COWAN, BARRY L. TUCKER
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Publication number: 20160030675Abstract: An assembly for a drug delivery device is provided, the assembly comprising at least one feedback feature. The feedback feature is configured to indicate the end of a dispense operation to a user by giving an audible and/or tactile feedback.Type: ApplicationFiled: March 10, 2014Publication date: February 4, 2016Inventors: Paul Richard Draper, Paul Griffin
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Publication number: 20160030676Abstract: A device for prevention of unintentional syringe aspiration includes a syringe cartridge. The syringe cartridge includes a syringe barrel having a first end and a second end, and an outlet at the second end. A plunger is slidably disposed in the barrel between the first end and the second end. A cap is engaged with the first end of the cartridge; and the cap includes a force element. When a substance in the barrel is cooled and frozen and then thawed, the force element tends to force the plunger to move back toward the second end of the barrel.Type: ApplicationFiled: April 3, 2014Publication date: February 4, 2016Inventors: Timothy Bresina, Michael Blomquist
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Publication number: 20160030677Abstract: Methods and systems for an injection system are provided. An example injection system includes a container for a pharmaceutical that is sealed at a proximal end with a plunger having a pushing surface for engaging an inner surface of the hollow body. A plunger rod extends axially from the proximal end of the container and is covered with a plunger rod cover. Removal of the cover activates the system and allows for delivery of the pharmaceutical product from the container by advancing the plunger within the container towards the seal.Type: ApplicationFiled: July 31, 2015Publication date: February 4, 2016Inventors: John Sundquist, Ben Rush, Edward Paul Browka, David L. Foshee, Gretchen E. Willard, Stephen Myers, Hector Rodriguez, John Coleman Horton, IV
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Publication number: 20160030678Abstract: Drive Mechanisnn of a Drug Delivery Device The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: —a housing (30) extending in an axial direction (1, 2), —a piston rod (90) to operably engage with a piston (16) of a cartridge (14) to displace the piston (16) in an axial distal direction (1), a last dose sleeve (100) rotatably supported in the housing (30) and being selectively engageable with a dose setting mechanism for setting of a dose, —a last dose member (105) threadedly engaged to the housing (30), rotatably locked to the last dose sleeve (100) and axially displaceable relative to the last dose sleeve (100).Type: ApplicationFiled: April 8, 2014Publication date: February 4, 2016Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Björn Wilden
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Publication number: 20160030679Abstract: A drug delivery system comprises means to create a log of expelled dose amounts of drug. Stored dose amounts determined within a given time period are combined to a single combined dose amount. The given time period is initiated by a detected expelling event taking place (i) a given amount of time after a previous detected expelling event, or (ii) after a given detected action. By this arrangement it is possible to create a log corresponding to what a user considers to be a single dose, i.e. combining “split doses” to create a single log entry for a per se split dose.Type: ApplicationFiled: April 3, 2014Publication date: February 4, 2016Inventors: Preben Mikael NIELSEN, Nikolaj Frogner KRUSELL
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Publication number: 20160030680Abstract: A supplemental device for attachment to an injection device, the supplemental device having a housing containing at least two electromechanical switches each having an open state and a closed state and a protrusion associated with each switch configured to protrude from the housing so as to contact a rotatable surface of the injection device while the supplemental device is attached to the injection device; and a processor arrangement configured to detect a change in the state of each of the switches; and to determine a direction of rotation of the rotatable surface of the injection device from the detected state changes.Type: ApplicationFiled: May 2, 2014Publication date: February 4, 2016Applicant: Sanofi-Aventis Deutschland GmbHInventors: Robert Veasey, David Aubrey Plumptre, Paul Richard Draper, David Richard Mercer
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Publication number: 20160030681Abstract: The invention refers to an injection device comprising a housing (10) having a first aperture (11) or window, a dose indicator (120) positioned within the housing (10) and rotatable with respect to the housing (10) during dose setting and during dose dispensing, and a gauge element (110), which is interposed between the housing (10) and the dose indicator (120). The gauge element (110) has a second aperture (111) or window, which is positioned with respect to the first aperture (11) or window of the housing (10) such that at least a part of the dose indicator (120) is visible through the first and second apertures (11, 111) or windows- Further, the gauge element (110) is axially guided within the housing (10) and in threaded engagement with the dose indicator (120) such that rotation of the dose indicator (120) causes an axial displacement of the gauge element (110).Type: ApplicationFiled: April 8, 2014Publication date: February 4, 2016Inventors: Matthew Jones, Simon Lewis Bilton
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Publication number: 20160030682Abstract: Described is a needle assembly retainer (1) comprising a body (2) adapted to hold a needle assembly (10). The needle assembly (10) comprises a hub (11) having an external surface (14) with at least one spline (15) and a needle having a proximal tip (10.1) and a distal tip (10.2). The body (2) has a proximal portion adapted to hold the hub (11) and a distal portion adapted to cover the distal tip (10.2). The needle assembly retainer (1) further comprises a resilient arm (6) formed on the proximal portion and adapted to engage the at least one spline (15) when the needle assembly (10) is rotated relative to the body (2).Type: ApplicationFiled: March 24, 2014Publication date: February 4, 2016Inventors: Uwe DASBACH, Peter NOBER, Fiete SONNTAG
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Publication number: 20160030683Abstract: Smart sensors are employed to determine one or more of drug identification, dose, flow rate, concentration, agglomeration, and degradation and/or other characteristics of drug administration that can be detected via sensing technology. A smart sensor(s) can be coupled to or retrofitted onto injection pen injectors and/or drug delivery cartridges and/or infusion sets or cannulae, enabling infusion sets, pen injector systems or drug delivery cartridges to improve tracking of drug self-administration and stop medication errors that occur primarily through self or automated injection (e.g., due to incorrect or incomplete dosing, excessive dose or rate, incorrect drug, or drug degradation).Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: BECTON, DICKINSON AND COMPANYInventors: Margaret Taylor, David Feygin, Elizabeth Nelson, Bart Peterson, Karthik Ranganathan, Richard Byrd
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Publication number: 20160030684Abstract: A luer adapter fitting has a luer at one end and an elongate cylindrical insert at another end. The insert has a plurality of longitudinal ribs spatially formed about the insert. Each of the ribs has a sharp longitudinal edge. A needle extends from the end of the insert away from the luer. The luer adapter fitting is press-fitted to an internally threaded through bore at the neck of a tube holder. The circumferential dimension formed by the plurality of ribs is larger than the opening of the threaded through bore, so that when the insert is press-fitted to the through bore, the longitudinal sharp edges of the ribs would score the threads at the through bore to prevent relative rotation between the fitting and the holder. A flange at the insert snap catches onto the interior shoulder of the holder to fixedly couple the insert to the holder.Type: ApplicationFiled: July 24, 2015Publication date: February 4, 2016Applicant: SMITHS MEDICAL ASD, INC.Inventor: Charles Pratt
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Publication number: 20160030685Abstract: Various embodiments of the present invention are directed to a device for the reduction of needle insertion site pain in patients. Various embodiments comprise a shell defining a hollow interior cavity filled at least in part by a freezable substance. The shell defines a first surface and a second surface opposite the first surface, and a passage extending through the shell between the first surface and the second surface, wherein the passage is configured to at least partially surround a needle insertion site while a needle is inserted therethrough. At least one of the first and second surfaces comprise a plurality of protrusions distributed therein and configured to be depressed into the skin of the patient. When chilled and depressed against the patient's skin, the freezable device provides a sensory confusion sensation to the patient, thereby reducing perceived pain caused by the needle insertion.Type: ApplicationFiled: June 26, 2015Publication date: February 4, 2016Inventor: Joshua Edward Lane
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Publication number: 20160030686Abstract: Devices are disclosed that include a positionable elongated member configured to support and delivery tube and maintain a distal end of the tube in a desired position, and to allow the position of the distal end of the tube to be adjusted by a user, and an attachment device configured to allow a proximal end of the elongated member to be secured in a fixed position. These devices may be used, for example, in the delivery of vaporized medicine to a patient, e.g., a child or infant on a bed.Type: ApplicationFiled: October 13, 2015Publication date: February 4, 2016Inventors: Sarah Cota, Mathew S. Smith
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Publication number: 20160030687Abstract: A delivery device includes a toroidal shaped housing defining an interior chamber and a central open space. The housing includes an input port communicating with the interior chamber and a delivery port positioned on an inner periphery of the housing. The delivery port is in fluid communication between the interior chamber and the central open space. The delivery port is spaced from the input port, which is adapted to receive an aerosolized medicament. In another aspect, a kit includes an outer ring-like housing component and a plurality of differently configured inner ring-like housing components mateable with the outer ring-like housing to form a holding chamber. A method of delivering an inhalable substance is also provided. A mask, including mounting and sealing portions is also provided, together with a method of manufacturing such a mask. Delivery devices include various alternative adapters to be used with a mask and a substance dispenser.Type: ApplicationFiled: September 15, 2015Publication date: February 4, 2016Applicant: TRUDELL MEDICAL INTERNATIONALInventors: DANIEL ENGELBRETH, MARTIN P. FOLEY, JERRY GRYCHOWSKI, JAMES SCHMIDT, JENNIFER PEVLER
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Publication number: 20160030688Abstract: A spacer chamber for an inhaler includes a housing chamber, a mouthpiece arranged on a side of the housing chamber, and a connecting means arranged on the housing chamber opposite to the mouthpiece to connect the inhaler. A lever means is held on the housing chamber which is movable to two positions and has an active surface that is arranged in such a manner that the active surface can act on an activation element of the inhaler in any one of the positions, if the inhaler is connected to the connecting means. The lever means includes a lever element and a lever carrier for carrying the lever element, which is fastened to the housing chamber.Type: ApplicationFiled: July 21, 2015Publication date: February 4, 2016Inventors: Ulf Krueger, Emir Jelovac, Birgit Lohre