Patents Issued in February 25, 2016
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Publication number: 20160053187Abstract: A method for producing a lubricating base oil, comprising: performing a 13C-NMR analysis regarding an oil to be treated and selecting the oil based on a value for dividing an integrated value of a peak for a tertiary carbon atom by an integrated value of all peaks at 0 to 50 ppm, a value for dividing an integrated value of a peak for a carbon atom constituting a main chain by the integrated value of all peaks at 0 to 50 ppm, and a value for dividing an integrated value of a peak for a branched CH3 bonded to a fifth or the following carbon atom from a terminal carbon atom in the main chain by an integrated value of all peaks at 10 to 25 ppm, and a obtaining a dewaxed oil by isomerization dewaxing of the oil selected in the first step, is disclosed.Type: ApplicationFiled: March 26, 2014Publication date: February 25, 2016Applicant: JX NIPPON OIL & ENERGY CORPORATIONInventors: Kazuaki HAYASAKA, Yasushi WADA, Marie IWAMA, Koshi TAKAHAMA
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Publication number: 20160053188Abstract: A process for taking non-treated re-refined vacuum gas oil and pretreating the product before the product is hydrotreated and used for fuel oil blends.Type: ApplicationFiled: August 17, 2015Publication date: February 25, 2016Inventor: Martin Weiler
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Publication number: 20160053189Abstract: The present invention provides a method for the conversion of asphaltenes to light fractions, including: a process of reacting a hydrogen donor solvent with an asphaltene-containing feedstock, and fractionating reaction products, where a weight ratio of the hydrogen donor solvent to the asphaltene-containing feedstock is 0.1-5:1, a weight hourly space velocity of the reaction is 0.2-5 h?1, reaction pressure is 0.5-25 MPa, reaction temperature is 360-500° C., and the hydrogen donor solvent is a solvent containing polycyclic aromatic compound having ?-hydrogen. The method according to the present invention can effectively achieve light fraction conversion of the asphaltenes to light fractions, and the process operation is simple.Type: ApplicationFiled: January 27, 2015Publication date: February 25, 2016Inventors: GANG WANG, JINSEN GAO, CHUNMING XU, NAN JIN
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Publication number: 20160053190Abstract: There is disclosed a system and method for processing diesel fuel from petroleum-based waste oil on a small scale compared to conventional methods for re-refining waste oil to a valuable product. In an embodiment, the method comprises dehydrating waste oil to remove water from the waste oil, and operating a vertical cylindrical reactor to induce pyrolysis of the dehydrated waste oil and convert it into a hydrocarbon vapour phase. The hydrocarbon vapour derived from pyrolysis is condensed and distilled using a distillation tower to produce diesel fuel, heavy liquid hydrocarbon, light liquid hydrocarbon and light hydrocarbon vapour. A filtering step cleans the processed diesel fuel to obtain a clean diesel fuel product.Type: ApplicationFiled: March 17, 2014Publication date: February 25, 2016Inventors: Orville Middleton, Bernhard G. Habicht (deceased), Todd Habicht, John Winram
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Publication number: 20160053191Abstract: Provided are a method of extracting a biodiesel convertible lipid from microalgae using a supercritical carbon dioxide and a biodiesel convertible lipid extracted by the method. The lipid extraction method is an economical and environmentally friendly technique, which may considerably reduce an extraction time, compared to a conventional supercritical carbon dioxide extraction method, does not use the toxic organic solvents used in the conventional Bligh-Dyer extraction method and Soxhlet extraction method, and exhibits an excellent lipid yield and a FAME yield.Type: ApplicationFiled: May 22, 2015Publication date: February 25, 2016Applicant: HANWOUL ENGINEERING INC.Inventors: Hyun KWAK, Dong Jun PARK, Kyung Seok CHOI, Jong Nam RAH
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Publication number: 20160053192Abstract: A method is disclosed for making a bright stock base oil blend meeting API Group II specifications. The method comprises blending (a) a major amount of a petroleum-derived bright stock component having kinematic viscosity at 100° C. of from 20 to 50 mm2/s with a sufficient amount of (b) a propylene oligomer component having a viscosity index of from 30 to 60, to provide a bright stock base oil blend having a higher viscosity than the petroleum-derived bright stock component and a higher viscosity index than the propylene oligomer component.Type: ApplicationFiled: August 21, 2014Publication date: February 25, 2016Applicant: CHEVRON U.S.A. INC.Inventor: Stephen Joseph MILLER
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Publication number: 20160053193Abstract: This invention is a composition of an ester resulting from the reaction of an oligomer of ethylene oxide in presence or a catalyst, with fatty acids. The resulting water based metal working fluid additive is useful as it imparts property of stable micro-emulsion and helps improving the wear life, coefficient of friction and other tribological properties among other uses.Type: ApplicationFiled: June 30, 2015Publication date: February 25, 2016Inventor: Ravi G.S.
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Publication number: 20160053194Abstract: The present invention relates to a lubricant base stock, a lubricant composition, a method of lubricating an object and the use of a lubricant base stock. The lubricant base stock comprises a first ester which is the reaction product of: a first polyol comprising at least 3 hydroxyl groups; a first mono-carboxylic acid comprising from 4 to 18 carbon atoms; and a poly-carboxylic acid comprising at least 2 carboxyl groups and comprising from 20 to 60 carbon atoms. The lubricant base stock also comprises a second ester which is the reaction product of: a second polyol comprising at least 3 hydroxyl groups; and a second mono-carboxylic acid comprising from 4 to 18 carbon atoms.Type: ApplicationFiled: August 19, 2014Publication date: February 25, 2016Applicant: CRODA, INC.Inventors: Jillian Carli Beyer, Alexei Nikolaevich Kurchan
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Publication number: 20160053195Abstract: Provided herein are processes of producing estolide base oils, including the process comprising providing at least one fatty acid ester, and contacting the at least one fatty acid ester with at least one fatty acid to form an estolide base oil. Exemplary processes include the use of transesterification to form the at least one fatty acid ester and/or estolide base oil.Type: ApplicationFiled: September 3, 2015Publication date: February 25, 2016Inventors: Jakob BREDSGUARD, Travis THOMPSON
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Publication number: 20160053196Abstract: Disclosed is a lubricating oil composition comprising: a lubricating base oil having a kinematic viscosity at 100° C. of 3.5 to 4.5 mm2/s, a viscosity index of 145 or greater, and an urea adduct value of 2 to 7% by mass; and a poly(meth)acrylate pour-point depressant containing structural units represented by the formula (1): wherein R1 represents a hydrogen atom and the like, R2 represents an alkyl group; based on the total amount of the units contained in the depressant, a ratio of the units wherein the R2 is a methyl group is 0 to 10 mol %, a ratio of the units wherein the R2 is an alkyl group having 12C or greater is 90 to 100 mol %; the alkyl group having 12C or greater has an average number of 13-16C; the depressant has a weight-average molecular weight of 10,000 to 200,000.Type: ApplicationFiled: March 26, 2014Publication date: February 25, 2016Applicant: JX NIPPON OIL & ENERGY CORPORATIONInventors: Kazuo TAGAWA, Kazuaki HAYASAKA
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Publication number: 20160053197Abstract: The present invention relates to an antiwear agent and lubricating compositions thereof. The invention further provides for a method of lubricating a driveline device application by employing a lubricating composition containing the antiwear agent.Type: ApplicationFiled: November 5, 2015Publication date: February 25, 2016Inventors: Morey N. Najman, Mark R. Baker, Vera M. Marsic
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Publication number: 20160053198Abstract: A reaction product, useful as a viscosity index improver in a lubricating oil, reacting: a) an oil soluble ethylene-alpha olefin copolymer comprising from 10 to less than 80 weight % ethylene and greater than 20 up to 90 weight % of at least one C3 to C28 alpha olefin, having a number average molecular weight from 5,000 to 120,000 and grafted with 0.5 to 5 weight % of an ethylenically unsaturated acylating agent, with b) a hydrocarbyl substituted poly(oxyalkylene) monoamine of the formula: R1—(O—CHR2—CHR3)x-A wherein: R1 is a hydrocarbyl group having from 1 to 35 carbon atoms; R2 and R3 are each independently hydrogen, methyl, or ethyl and each R2 and R3 are independently selected in each —O—CHR2—CHR3— unit; A is amino, —CH2amino or N-alkyl amino having 1 to 10 carbon atoms; and x is an integer from 2 to 45.Type: ApplicationFiled: November 3, 2015Publication date: February 25, 2016Inventor: William Raymond Ruhe, JR.
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Publication number: 20160053199Abstract: The present invention relates to a method and to an apparatus for extracting virgin olive oil from olives and other oil-fruits allowing to reduce the production time by guarantee the product qualitative level.Type: ApplicationFiled: March 18, 2013Publication date: February 25, 2016Inventor: Maria Lisa CLODOVEO
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Publication number: 20160053200Abstract: (Meth)acrylates are prepared in a single-step method from a mixture of (meth)acrylic acid and at least one biobased oil and/or its derivative(s), including at least one unsaturation. The (meth)acrylates are made by directly adding the (meth)acrylic acid to the biobased oil by reacting in the presence of an acid catalyst, including an inorganic or organic acid having at least one oxygen atom present thereon and which possesses at least one acid functionality having an ionization constant in water which is not greater than 3.Type: ApplicationFiled: May 1, 2014Publication date: February 25, 2016Inventors: Joshua L. Colby, Lianzhou Chen, Kwame Owusu-Adom, Aaron E. Hutt
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Publication number: 20160053201Abstract: Compositions, process mixtures, methods, and kits are provided for removing one or more coatings from a polymeric substrate using single-phase aqueous solution. The single-phase aqueous solution may include an inorganic base composition, a surfactant composition including one or more alkylglycosides, and water.Type: ApplicationFiled: August 19, 2015Publication date: February 25, 2016Inventors: Douglas R. Gels, Anne B. McCoppin
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Publication number: 20160053202Abstract: The present invention concerns the use of C16-alkyl betaine as a fabric softener, notably for fabric softening compositions. The invention also concerns a method of treating fabric which comprises the step of contacting said fabric in the rinse cycle of a fabric washing machine with an aqueous medium containing a composition as defined herein.Type: ApplicationFiled: March 25, 2014Publication date: February 25, 2016Inventors: Lin HE, Hai Zhou ZHANG
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Publication number: 20160053203Abstract: Compositions and methods are disclosed which are effective for removing or stripping varnish and paint or stains from surfaces such as wood or metal which comprises activating NMP and/or BLO with 1-20% by weight of ethyl 3-ethoxypropionate (EEP), preferably 2-15%, and optimally about 3-5%, and with 0.1-10% by weight of NOP/ALC EO, preferably 0.2-5%, most preferably 1 -3% by weight and/or 0.1-5% by weight of Silwett 77, preferably 0.2-3%, and most preferably 0.Type: ApplicationFiled: August 19, 2015Publication date: February 25, 2016Inventor: KOLAZI S. NARAYANAN
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Publication number: 20160053204Abstract: Compositions, process mixtures, and kits are provided for removing one or more coatings from a polymeric film, e.g., a food packaging film, using a single-phase aqueous solution. The single-phase aqueous solution may include water; an inorganic base composition; one or more of a stable peroxygen composition and a monosaccharide salt; and a surfactant composition.Type: ApplicationFiled: August 19, 2015Publication date: February 25, 2016Inventors: Douglas R. Gels, Kenneth J. Heater, Anne B. McCoppin
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Publication number: 20160053205Abstract: Compositions, process mixtures, kits, and methods are provided for removing one or more coatings from a polymeric substrate using a single-phase aqueous solution. The single-phase aqueous solution may include water and an organic ester fraction. The organic ester fraction may include one or more alkyldioic acid dialkylesters.Type: ApplicationFiled: August 19, 2015Publication date: February 25, 2016Inventors: Kenneth J. Heater, Anne B. McCoppin, Douglas R. Gels
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Publication number: 20160053206Abstract: Method of cleansing human skin employing an aqueous soap composition comprising of fatty acid soap, at least one silver (I) compound having a silver ion solubility (in water at 25° C.) of at least 1×10?4 mol/L,and water, which composition provides biocidal activity against Gram positive bacteria in particular S. aureus, in relatively short contact periods.Type: ApplicationFiled: April 9, 2014Publication date: February 25, 2016Applicant: Conopco, Inc., d/b/a UNILEVERInventors: Prem CHANDAR, Guohui WU, Nitish KUMAR, Varnsi Krishna MANTHENA, Vibhav Ramrao SANZGIRI, Anat SHILOACH
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Publication number: 20160053207Abstract: A soap bar comprising: (a) 25 to 85% by weight, based on the total weight of the bar, of fatty acid soap; (b) 0.1 to 100 ppm by weight, based on the total weight of the bar, of at least one silver (I) compound having a selected silver ion solubility, wherein at 25° C., a 1 wt % solution of the bar in water has a pH of from 9 to 11.Type: ApplicationFiled: April 9, 2014Publication date: February 25, 2016Applicant: Conopco, Inc., d/b/a UNILEVERInventors: Prem CHANDAR, Guohui WU, Nitish KUMAR, Vamsi Krishna MANTHENA, Kalpana Kamalakar NAYAK, Vibhav Ramrao SANZGIRI, Anat SHILOACH
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Publication number: 20160053208Abstract: A cosmetic brush cleanser having a solid goat's milk soap base and comprising almond oil, jasmine oil, coconut oil, and lavender oil.Type: ApplicationFiled: August 20, 2015Publication date: February 25, 2016Inventor: Christina Bartelt-Kelly
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Publication number: 20160053209Abstract: A process of producing a paste-form, detergent composition comprises admixing/mixing a particulate detergent composition with a liquid.Type: ApplicationFiled: February 22, 2013Publication date: February 25, 2016Inventors: Roberto Casonati, Igor DABALA, Umberto TONIOLO, Giuseppe DI BONO, Ralf Wiedemann
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Publication number: 20160053210Abstract: A method for producing a beer-taste beverage, characterized in that the method includes adding a hop bract-containing composition having an ?-acid content of less than 1% by weight of the composition in the step of producing a beer-taste beverage. According to the present invention, by the use of the hop bracts, it is possible to realize a balance between the bitterness, aroma derived from hops, and taste that cannot be achieved by a conventional production method. By appropriately adjusting the timing of adding hop bracts, beer-taste beverages having preferred features and strength of the aroma and controlled taste can be provided.Type: ApplicationFiled: February 26, 2014Publication date: February 25, 2016Applicant: Suntory Holdings LimitedInventors: Tomoyuki Nakahama, Takako Inui, Daisaku Yonezawa
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Publication number: 20160053211Abstract: The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of using the polypeptides in beer production.Type: ApplicationFiled: April 11, 2014Publication date: February 25, 2016Applicant: Novozymes A/SInventors: Martin Simon Borchert, Morten Gjermansen, Peter Rahbek Oestergaard, Lone Baekgaard, Alexander Mauch, Hans Peter Heldt-Hansen, Anne Mette Bhatia, Christina Lund, Miguel Duarte Guilherme Pereira Toscano
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Publication number: 20160053212Abstract: The present invention relates to a method for the preparation of a fining agent or yeast flocculating preparation, the method comprising extracting hops with an organic solvent, an aqueous solvent or a mixed solvent. The invention further provides for the use of fining agent or yeast flocculating preparations.Type: ApplicationFiled: March 21, 2014Publication date: February 25, 2016Inventors: David Cook, Robert Linforth
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Publication number: 20160053213Abstract: Aspects of the disclosure relate to bioreactors for maintaining biological objects (e.g., organ or engineered tissues) under culture conditions. In some embodiments, bioreactors and cover assemblies are provided that comprise a support base for supporting a biological object. In some embodiments, bioreactors and cover assemblies are provided that comprise a movable support base configured such that a user can manipulate its position and thus the relative position of the biological object.Type: ApplicationFiled: March 27, 2014Publication date: February 25, 2016Applicant: Harvard Apparatus Regenerative Technology, Inc.Inventor: Herbert Hedberg
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Publication number: 20160053214Abstract: Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a CO2 module, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.Type: ApplicationFiled: November 2, 2015Publication date: February 25, 2016Inventors: Gordana VUNJAK-NOVAKOVIC, Warren GRAYSON, Qun WAN, Donald O. FREYTES, Amandine GODIER-FURNEMONT, Nina TANDON, Keith YEAGER, George ENG, Sarindr BHUMIRATANA, Robert MAIDHOF
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Publication number: 20160053215Abstract: A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well.Type: ApplicationFiled: November 3, 2015Publication date: February 25, 2016Applicant: APPLIED BIOPHYSICS, INC.Inventor: Christian W. RENKEN
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Publication number: 20160053216Abstract: A machine having a housing and an inner receptacle provided inside the housing with at least one tube therein holding the blood desired to be separated for separation of blood into white blood cells. The machine includes the following: at least one coil provided with at least one tube slot formed thereon so as to house the at least one tube and creating a magnetic field on the tube by means of the electric current passed therethrough; at least one motor enabling the coil to be rotated around its own axis so as to create a centrifugal effect on the tube; and at least one injector enabling the separated blood components to be transferred into the determined tubes by entering into the tubes.Type: ApplicationFiled: March 27, 2014Publication date: February 25, 2016Inventors: Orhan ÇEVIK, Melike DEMIRCI
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Publication number: 20160053217Abstract: The present invention relates to an automatic stimulator based on vibrations for cell cultures, fulfilling the function of activating the proliferation of osteoprogenitor cells and of activating the expression of the genes involved in the process of cell differentiation toward the osteogenic line. This effect is produced in the cells by the application of mechanical vibrational load. In this respect, the operation of the stimulator of the present invention comprises a system incorporating an actuator of mechanical type, controlled and regulated according to the specific requirements defined by the user. The actuator is the source of the vibrations which will be applied upon the flasks containing the cell cultures.Type: ApplicationFiled: March 14, 2014Publication date: February 25, 2016Inventors: Jorge Arturo REY CUBILLOS, Astrid RUBIANO FONSECA
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Publication number: 20160053218Abstract: Described herein are systems, methods and kits for culturing and applying fresh microbial inoculants in the field. The system, methods and kits are easy to use, reliable, sealed to prevent contamination, and can be stored on location, for use on demand by those unskilled in the microbiological arts. Particular embodiments described herein may be used to increase agricultural crop yields.Type: ApplicationFiled: December 10, 2014Publication date: February 25, 2016Applicants: Ohio State Innovation Foundation, 3Bar Biologics, Inc.Inventors: Bruce H. CALDWELL, Brian B. McSPADDEN GARDENER
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Publication number: 20160053219Abstract: Systems, methods, and devices are disclosed for improved temperature control, particularly within a predetermined range of temperatures near or above varying ambient temperatures. Previously-unrealized advantages are recognized for maintaining samples, particularly medical and/or biological specimens, at a temperature within a predetermined range of temperatures near or above ambient temperature that selectively promote and/or selectively inhibit organism growth, organism viability, biochemical reactions, and/or chemical reactions. Systems, methods, and devices may include at least phase change material selected and configured to maintain a sample at a predetermined temperature range between about 22° Celsius and about 100° Celsius during a predetermined time period.Type: ApplicationFiled: August 25, 2015Publication date: February 25, 2016Inventors: George Terrance Walker, Tony Rockweiler
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Publication number: 20160053220Abstract: The present invention provides an apparatus and methods for simultaneously producing different compounds in various ratios under set conditions.Type: ApplicationFiled: August 25, 2015Publication date: February 25, 2016Applicant: FULL SPECTRUM LABORATORIES LIMITEDInventors: RICHARD PEET, Mingyang Sun
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Publication number: 20160053221Abstract: The invention provides methods and compositions (such as for example, culture media) for culturing Clostridium difficile and producing the C. difficile Toxins A and B.Type: ApplicationFiled: August 24, 2015Publication date: February 25, 2016Inventors: Aiqi FANG, Andrew James WHITE, Seshu TUMMALA, Lee WILSON
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Publication number: 20160053222Abstract: Herein a Bacillus exosporium molecule delivery (BEMD) system that provides a means to deliver molecules of interest (MOIs) to an environment is disclosed. The system results in the display of MOIs on the exosporium surface of Bacillus family members such that they can be delivered to an environment in a stable and active form. In addition, methods of making and using the system are described.Type: ApplicationFiled: September 9, 2015Publication date: February 25, 2016Inventors: George C. Stewart, Brian Matthew Thompson, Chung-Ho Lin
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Publication number: 20160053223Abstract: The invention relates generally to methods and compositions for maintaining and manipulating microbial cultures of Gram-positive bacteria. Also provided are methods for identifying quorum sensing regulatory proteins and auto-inducing peptides in Gram-positive bacteria. Also provided are methods and compositions for affecting quorum sensing pathways of the genus Clostridium in culture including auto-inducing peptides to direct or maintain Clostridium cultures in a desired differentiated state. Differentiated states include extended serial propagation for the production of butanol or other fermentation products.Type: ApplicationFiled: November 9, 2015Publication date: February 25, 2016Inventor: Donald Mattsson
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Publication number: 20160053224Abstract: The present invention relates to the use of a combination of: (i)a macromolecular erythrocyte sedimentation enhancer, and (ii) dimethyl sulphoxide (DMSO), dimethylglycine (DMG) and/or valine; to recover non-erythrocyte blood cells from a blood cell-containing sample and/or to prime non-erythrocyte blood cells to protect their integrity in subsequent cryopreservation step(s).Type: ApplicationFiled: April 15, 2014Publication date: February 25, 2016Inventor: Jeffrey Drew
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Publication number: 20160053225Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or Inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.Type: ApplicationFiled: March 27, 2014Publication date: February 25, 2016Applicant: GE Healthcare Bio-Sciences ABInventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
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Publication number: 20160053226Abstract: The present invention relates to a method for amplifying a population of neural precursors comprising the step of culturing neural precursors in the presence of a PKA inhibitor.Type: ApplicationFiled: April 15, 2014Publication date: February 25, 2016Inventors: Marc Peschanski, Alexandra Benchoua
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Publication number: 20160053227Abstract: This invention relates to an agent for inducing differentiation of white adipocytes into brown-like adipocytes comprising a compound which is a cyclization reaction product of a hydroxystilbene and which is represented by Formula (1): (wherein each of R1 to R8 is a hydrogen atom, a hydroxyl group, a saturated or unsaturated, straight or branched alkoxy group having 1 to 10 carbon atoms, or a saturated or unsaturated, straight or branched alkyl group having 1 to 10 carbon atoms, and R1 to R8 may be same or different), or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: February 27, 2014Publication date: February 25, 2016Applicant: UHA Mikakuto Co., Ltd.Inventors: Yasuhiro SHINKA, Akinobu KISHI, Taiji MATSUKAWA, Takeki MATSUI, Yasumasa YAMADA, Ichiro YAMADA
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Publication number: 20160053228Abstract: A method for isolating and proliferating at least one type of precursor cell from dental origin from a single donor includes the following isolating the precursor cells from dental origin of a single donor in a sample collection media and preparing a primary stock culture. The primary stock culture is proliferated sequentially to obtain first, second and third sub-cultured stocks with cell counts ranging between 5×106 cells and 10×106 cells, 20×106 cells and 400×106 cells, 150×106 and 300×106 cells respectively. The precursor cells from the third subculture are harvested and cryo-preserved to obtain a precursor cell population for cell transplantation. The dental origin of the precursor cells is from pulp, apical papilla or periodontal ligament. The precursor cell originates from mesenchymal stem cells, ecto-mesenchymal cells, neural stem cells, dental progenitor cells or CD117+ cells.Type: ApplicationFiled: August 20, 2015Publication date: February 25, 2016Inventors: Vijayendran GOVINDASAMY, Premasangery KATHIVALOO
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Publication number: 20160053229Abstract: The present invention provides Jagged 1 and Frizzled 4 as cell surface markers for isolating human cardiomyogenic ventricular progenitor cells, in particular progenitor cells that preferentially differentiate into cardiac ventricular muscle cells. Thus, the invention provides human ventricular progenitor (HVP) cells. The invention provides in vitro methods of the separation of Islet 1+ Jagged 1+ ventricular progenitor cells and/or Islet 1+/Frizzled 4+ ventricular progenitor cells and/or Islet 1+/Jagged 1+/Frizzled 4+ ventricular progenitor cells, and the large scale expansion and propagation thereof. Large clonal populations of isolated Jagged 1+ and/or Frizzled 4+ventricular progenitor cells are also provided. Methods of in vivo use of Jagged 1+ and/or Frizzled 4+ ventricular progenitor cells for cardiac repair or to improve cardiac function are also provided. Methods of using the Jagged 1+ and/or Frizzled 4+ ventricular progenitor cells for cardiac toxicity screening of test compounds are also provided.Type: ApplicationFiled: August 21, 2015Publication date: February 25, 2016Inventors: Kenneth R. CHIEN, Xiaojun LIAN
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Publication number: 20160053230Abstract: Provided are a method of inducing differentiation of pluripotent stem cells, such as induced pluripotent stem cells (hereinafter abbreviated as iPS cells), to hepatocytes in a short period of time, and a substance to be used in the method. Specifically, provided are a method of producing a cell culture formed substantially of hepatoblasts, the method including culturing pluripotent stem cells, such as iPS cells, in a culture medium having a composition shown in Table 1 below, and a culture medium for inducing differentiation of pluripotent stem cells into hepatoblasts, which has a composition shown in Table 1 below.Type: ApplicationFiled: June 25, 2015Publication date: February 25, 2016Inventor: Minoru Tomizawa
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Publication number: 20160053231Abstract: A microfabricated multi-tissue system for in vitro drug toxicity testing having a plurality of layers, each of which is formed of decellularized tissue extracellular matrix (ECM) including parenchymal cells and non-parenchymal cells attached thereto. Also disclosed is a method for producing a decellularized ECM paste, and methods for producing an ECM construct and a porous 3-D scaffold from the decellularized ECM paste.Type: ApplicationFiled: April 9, 2014Publication date: February 25, 2016Inventor: Qiaobing Xu
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Publication number: 20160053232Abstract: This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.Type: ApplicationFiled: September 4, 2014Publication date: February 25, 2016Inventors: Harry E. Gruber, Douglas J. Jolly, Omar D. Perez, Christopher R. Logg
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Publication number: 20160053233Abstract: The present invention discloses a method for terminal inactivation of pathogenic microorganisms, comprising the following steps of: a. vacuum freeze-drying a bio-product packaged in a container, feeding in a gas and sealing to obtain the end product and, b. performing inactivation by dry-heating. The method provided by the present invention can effectively inactivate non-lipid enveloped viruses, with excellent inactivation effects and short inactivation time particularly to parvoviruses, and thus overcome the deficiencies of the conventional terminal dry-heating inactivation methods.Type: ApplicationFiled: December 22, 2014Publication date: February 25, 2016Inventors: Shuguang Ran, Qiang Wang, Dexi Jiang
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Publication number: 20160053234Abstract: The present invention relates to a composition comprising bacteriophage SP-1, the bacteriophage capable of destroying Salmonella once being infected in Salmonella, as an active ingredient, and a method for prevention and treatment of Salmonella infection using the same. Bacteriophage SP-1, the active ingredient of the composition of the present invention, characteristically has the killing activity to Salmonella and has the genome represented by SEQ. ID. NO: 1.Type: ApplicationFiled: November 6, 2015Publication date: February 25, 2016Inventors: Seong Jun Yoon, Sooyoun Jun, Hyoungrok Paik, Gimo Jung, Yoonsik Shin, Sanghyeon Kang
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Publication number: 20160053235Abstract: Methods of assembling modified adenoviruses, libraries of adenoviral gene modules and compositions thereof are provided herein.Type: ApplicationFiled: November 9, 2015Publication date: February 25, 2016Applicant: Salk Institute for Biological StudiesInventors: Clodagh O'Shea, Colin Powers
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Publication number: 20160053236Abstract: Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral drug intermediates, an environmentally friendly solution that can be used to generate pharmaceuticals at much lower costs than conventional techniques. In this context, embodiments of the invention comprise methods and materials designed to allow microorganisms to biosynthesize the nonnatural amino acid L-homoalanine. As is known in the art, L-homoalanine is a chiral precursor of a variety of pharmaceutically valuable compounds including the anticonvulsant medications levetiracetam (sold under the trade name Keppra®) and brivaracetam, as well as ethambutol, a bacteriostatic antimycobacterial drug used to treat tuberculosis. Consequently, embodiments of the invention can be used in low cost, environmentally friendly processes to generate these and other valuable compounds.Type: ApplicationFiled: October 9, 2015Publication date: February 25, 2016Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: James C. Liao, Kechun Zhang, Kwang Myung Cho