Abstract: A crankshaft flaw detection device (1) used for detecting flaws in the crank pin, web, and fillet section of a crankshaft comprises: a pair of shaft flaw detection heads (2, 3) configured so as to be capable of sandwiching the crank pin (C2) therebetween, and having a first probe (2b) capable of detecting flaws on the shaft surface of the crank pin (C2) or a second probe (3b) capable of detecting flaws in a fillet section at the base of the shaft; and a perpendicular surface flaw detection head (4) configured so as to be capable of coming in contact with the crank pin (C2) and having a third probe (4b) capable of detecting flaws in the side surface of the web (C3).

Abstract: Embodiments of the present invention feature methods and apparatus for performing chromatographic separations. The invention feature methods and control means in the form of computer programs and software that control the formation of a concentration gradient at two or more total flow rates, with an elution period occurring in a slow flow rate and at least other portions of the gradient occurring during a fast total flow rate.

Abstract: A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position.

Abstract: This analysis method includes: subjecting a sample solution of a dye-containing sample in an organic solvent to normal-phase liquid chromatography to separate the sample solution and detect separated components. The normal-phase liquid chromatography involves (B1) using a separation column filled with a column packing material which is prepared by modifying a base material with a polar modifying group, and (B2) using as an eluent a polar organic solvent containing an acid.

Abstract: An odor sensing system including a plurality of odor sensors, each odor sensor being configured to output a detection signal in response to at least one odor molecule; at least one chromatographic membrane disposed at the plurality of odor sensors through which the odor molecule diffuses to reach the odor sensor; and a pattern analyzer configured to analyze the detection signals over time to identify the odor molecule is described.

Abstract: A method of using an absorptive sensor element includes: providing the absorptive sensor element, heating the absorptive sensor element to a temperature in a range of from 30° C. to 100° C., exposing the absorptive sensor element to an analyte vapor, and measuring a capacitance-related property of the absorptive sensor element and/or a spectral feature upon reflection of incident light. The absorptive sensor element comprises: a substrate, a first member disposed on the substrate, a second member, and a detection layer comprising a polymer of intrinsic microporosity disposed between and contacting the first member and the second member.

Abstract: An antenna installation comprises a plurality of antenna assemblies (10) mounted in respective enclosures (12). The enclosures are interconnected by flow connections (14) allowing passage of dry air supplied from a dry air panel (16). Having passed through all the enclosures, the dry air exhausts through a dry air return (18). The dew point of the air in the dry air return is detected by a dew point sensor (22). An air flow sensor (24) is disposed downstream of the dew point sensor and signals alarm if the air flow falls below a preset threshold.

Abstract: Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (NO) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of NO being delivered to the patient that can drive one or more baseline calibrations. The calibration schedules can be used reduce the amount of times the sensor goes offline. Systems and methods described may factor in in actions occurring at the delivery system and/or aspects of the surrounding environment, prior to performing a baseline calibration, and may postpone the calibration and/or rejected using the sensor's output for the calibration.

Abstract: A flammable gas concentration detection apparatus (1) including an energization control unit (50) that switches the energization state of heating resistor (34) at regular time periods TW, and a gas concentration computation unit (7). The heating resistor has first and second set temperatures CH and CL. The voltage detected across the heating resistor at the first and second set temperatures corresponds to a high and low temperature voltage, respectively. The gas concentration computation unit computes the concentration of a flammable gas based on a first information group including an average high temperature voltage averaging the values of two temporally successive high temperature voltages, the low temperature voltage in a period of time between two high temperature voltages, and an environment temperature in the period of time in which the low temperature voltage is detected.

Abstract: A method and apparatus are described for detecting the presence of explosives. The invention utilizes Laser Induced Acoustics (LIA), wherein an area of a substrate surface is irradiated, via deep UV pulsed laser, with laser pulses to generate a detectable audible signal. The invention also provides substantial improvements in the eye-safety of otherwise potentially harmful laser beams. Thus, the invention is particularly well-suited to use in public venues where detection of explosives or improved laser safety may be required.

Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.

Abstract: A method of analyzing a biological sample, for example serum or other blood-based samples, using a MALDI-TOF mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a MALDI-TOF sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument. In some embodiments at least 100,000 laser shots and even 500,000 shots are directed onto the sample. It has been discovered that this approach, referred to as “deep-MALDI”, leads to a reduction in the noise level in the mass spectra and that a significant amount of additional spectral information can be obtained from the sample. Moreover, peaks visible at lower number of shots become better defined and allow for more reliable comparisons between samples.

Abstract: The present invention discloses a biological measuring device with auto coding capabilities. In accordance with one embodiment of the present invention, the biological measuring device with auto coding capabilities may include a test strip associated with a code pattern; and a code reader electrically coupled to the test strip to read the code pattern, wherein the code reader is configured to read an output from the code pattern consisted of a first logical value, a second logical value, and a third logical value.

Abstract: The present invention generally relates to an apparatus, method, system for the determination of the aggregation rate of red blood cells. More specifically, the invention concerns a method, system, and the relative apparatus used to determine the aggregation rate of red blood cells, and other parameters related to these, such as viscosity, deformability, elasticity, density, in the field of in vitro medical analyses, using optical systems after or during inducted forces for red blood cell disruption and redistribution generated by ultrasound waves.

Abstract: Electrophysiology culture plates are provided and are formed from a transparent microelectrode array (MEA) plate. The MEA plate comprises a substrate, a first layer and a first insulating layer. The substrate has a plurality of vias extending from an upper to a lower surface, each via being in electrical contact with each of a plurality of contact pads disposed on the lower surface. The first layer is disposed on the upper surface of the substrate and has a plurality of MEA arrays in in electrical communication with at least a first routing layer. Each MEA array comprises a plurality of reference electrodes and a plurality of microelectrodes and the first routing layer is in electrical communication with a select number of the plurality of vias. A first insulating layer is disposed on the first layer.

Abstract: A cell sorter including a well that has a microspace filled with a liquid and having a typical length of 1 mm or less, and that has a bottom surface made of a light-permeable material allowing optical observation of an interior of the microspace; a matrix provided on the bottom surface in the well; a bone fragment placed on the matrix in the well; and osteoclasts placed between the matrix and the bone fragment.

Abstract: The present invention provides methods of identifying subjects that are suitable and not suitable for high-dose cyclophosphamide treatment.

Abstract: A quantum dot-polymer nanocomposite for optical chemical and biological sensing is formed by stably incorporating functionalized quantum dots into a pH sensitive hydrogel polymer network. At least one monomer of the pH sensitive hydrogel has functional groups selectively chosen to correspond to functionalized groups on the quantum dots to enable conjugation between the hydrogel polymer network and the functionalized quantum dots. The resulting quantum dot-polymer nanocomposite is placed in a solution having a known pH and addition of a chemical composition or biological agent of interest generates a change in pH of that solution. The nanocomposite expands or contracts responsive to the pH change. The pH change is optically detected by measuring the intensity level of fluorescence from the quantum dots when the nanocomposite is subjected to an excitation light source.

Abstract: Methods, assays, and products for the detection of small molecules are provided. In one aspect, for example, a method of detecting a small molecule in a sample can include reacting together a first half of a DNA split aptamer having a first reactive group coupled thereto, a second half of a DNA split aptamer having a second reactive group coupled thereto, where the DNA split aptamer is selective for the small molecule, and a sample containing the small molecule. The first half and the second half bind to the small molecule and the first reactive group and the second reactive group react to form an aptamer ligation product of the first half and the second half. The method can also include assaying for the aptamer ligation product in order to detect the small molecule presence in the sample.

Abstract: Compounds that exhibit aggregation induced emission (AIE), and more particularly to water-soluble conjugated polyene compounds that exhibit aggregation induced emission. The conjugated polyene compounds can be used as bioprobes for DNA detection, G-quadruplex identification, and potassium-ion sensing. The polyenes also can be utilized as an external fluorescent marker to study conformational structures, to monitor folding processes of label-free oligonucleotides with G-rich strand sequences, and to visualize DNA bands in PAGE assay. The polyenes have applications in high-throughput anticancer drug screening and are useful for the development of efficient anti-cancer drugs. Furthermore, the present subject matter can also be used to monitor fibrillation of amyloid proteins and to facilitate the storage and delivery thereof.

Abstract: The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject having celiac disease.

Abstract: Disclosed herein is a method of detecting and identifying antigens that are shed into human bodily fluids during infection. The disclosed method allows circulating antigens associated with a particular infection to be detected within minutes or hours from testing as compared to days required with the current methods. Methods of identifying diagnostic indicators/targets for a given condition or disease are disclosed which include immunizing a verterinary subject with biological fluids obtained from a human infected with particular antigens to identify diagnostic targets for immunoassay. Also disclosed are methods of diagnosing and monitoring a B. pseudomallei-associated condition, such as melioidosis. Point-of-care immunoassays are also provided that can be used to diagnose or monitor the efficacy of a B. pseudomallei-associated condition treatment. These immunoassays can also be used for rapid diagnosis of infection produced by B. pseudomallei, such as meliodosis.

Abstract: Provided are a method for accurately evaluating the differentiation status of stem cells by selectively staining only stem cells in an undifferentiated state, and a method for positively isolating only stem cells in an undifferentiated state. Specifically provided is a method for determining differentiation of a cell comprising a step of contacting a test cell with a probe comprising protein (A) or (B) below and a step of detecting the presence of binding of the probe to the test cell. The method for determining differentiation of a cell is capable of detecting the presence or absence of an undifferentiated stem cell in test cells by using a probe that specifically reacts with undifferentiated stem cells and detecting the presence of bonding to the test cell.

Abstract: Cell binding peptides are provided for binding to cells including urothelial and thyroid follicular cells. The peptides are useful for detection and diagnosis of cancer including bladder and thyroid cancer. A device and method for using the device for capturing cells is provided, the device includes a support having attached cell binding peptide. The support can be a slide and the device can be used for detection and diagnosis of cancer including bladder and thyroid cancer. A kit is provided with instructions for capturing cells and a support with attached cell binding peptide for detection and diagnosis of bladder and thyroid cancer.

Abstract: Disclosed herein are methods of predicting whether or not a subject will benefit from treatment with a Src inhibitor on the basis of the expression of one or more of Von Hippel Lindau (VHL), Src, PTP1B, pFAK, HIF-1?, and/or CA-IX in a tumor sample from the subject.

Abstract: The present invention relates to the prognosis, therapeutic stratification and treatment of colorectal cancer. More in particular, the present invention discloses that significantly increased levels of transmembrane type 1 neuregulin-1 in tumor-associated mesenchymal cells present in a sample of a patient indicate that the patient has a worse prognosis when compared to patients having low levels of transmembrane type 1 neuregulin-1 in tumor-associated mesenchymal cells. Moreover, the present invention relates to the usage of transmembrane type 1 neuregulin-1 expression in tumor-associated mesenchymal cells to predict resistance to HER1 inhibitors during colorectal cancer therapy and/or to predict whether a patient would benefit from a therapy based on the prevention of neuregulin-1 and/or HER3 activity.

Abstract: The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.

Abstract: The present invention generally relates to an apparatus for structural mapping of a macromolecule comprising an amount of persulfide effective to generate hydroxyl radicals upon contact with an aqueous solution. The present invention further relates to methods for structural mapping a macromolecule in an aqueous solution and methods for structural mapping a plurality of macromolecules in parallel, wherein each macromolecule is in a separate aqueous solution.

Abstract: The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of Streptococcus pneumoniae infections. In particular, these antibodies may kill Streptococcus pneumoniae or limit the replication of Streptococcus pneumoniae. Also disclosed are improved methods for producing such monoclonal antibodies.

Abstract: The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin.

Abstract: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.

Abstract: A non-optical bio-disc, a bio-disc device including the non-optical bio-disc and/or optical disc, a bio-driver apparatus in which a controller disc including a controller for the bio-disc is installed, and an assay method using the same, which are suitable for labs-on-a-chips for various diagnostic assays, nucleic acid hybridization assays, and immunoassays, are provided. The bio-driver apparatus is compatible with general optical discs, including audio, CD-ROMs, DVD players, etc. Thus, the bio-driver apparatus and the assay method offer and economical and convenient alternative to existing products. In addition, the bio-driver apparatus can be readily and easily applied in connection with a computer for remote diagnosis via the internet.

Abstract: A sample processing system is disclosed which includes at least one processor and at least one memory that stores programs executable collectively by the at least one processor. According to the stored programs, the at least one processor transports sample containers through a conveying path along which there are arranged at least one first module for testing of samples and at least one second module for processing of samples which have been tested by the at least one first module. The at least one second module is switchable between an active state and an inactive state. The at least one processor further obtains a determination result as to whether a sample which has been tested by the at least one first module is necessary to be processed by the at least one second module.

Abstract: A method for manipulating a droplet by a droplet manipulating device including a flow channel, a first magnetic field generator, and a second magnetic field generator is provided. The first magnetic field generator includes two first magnetic field modules and are at two sides of the flow channel. The second magnetic field generator is between the two first magnetic field modules and includes multiple second magnetic field coils. The droplet is provided in the flow channel and includes a magnetic particle. A first magnetic field is produced on the flow channel by the first magnetic field modules, so the magnetic particle in the droplet has the direction of magnetic field corresponding to the first magnetic field. A second magnetic field is produced on the flow channel by the second magnetic field coils, for driving the magnetic particle in the droplet to be in motion in the flow channel.

Abstract: A system for heating the sound-reflective mirror surface of a phased array monostatic sodar apparatus. The system has a heat source located at a position that is spaced from the mirror, a control system that controls the operation of the heat source, a working fluid that is heated by the heat source and used to transfer heat from the source to the mirror, and a delivery system that constrains the heated working fluid and delivers it from the heat source to the mirror.

Abstract: A micromechanical structure includes: a substrate which has a main plane of extension; and a mass which is movable relative to the substrate, the movable mass being elastically suspended via at least one coupling spring. A first subregion of the movable mass is situated, at least partially, between the substrate and the coupling spring along a vertical direction which is essentially perpendicular to the main plane of extension.

Abstract: There is provided an optical accelerometer including a first substrate, a second substrate, a spacer and a processing unit. The first substrate includes a frame, a movable member and at least one elastic member. Periodic slots are formed on the movable member along at least one direction to be served as a diffraction grating. The elastic member is connected between the frame and the movable member. The second substrate includes at least one sensing unit configured to detect a diffraction pattern formed by the diffraction grating. The spacer is disposed between the first substrate and the second substrate to define a predetermined height. The processing unit is coupled to the sensing unit and configured to calculate a 3D acceleration according to the diffraction pattern.

Abstract: Accelerometers and associated techniques for detecting motion are described. For a resonant accelerometer, an externally-applied acceleration can cause a change in the electrical spring constant Ke of the electromechanical system. A resonant accelerometer can be driven to resonate in a bulk acoustic wave mode of vibration, which can have a high resonant frequency. Other accelerometers and associated techniques are disclosed.

Abstract: A MEMS-sensor structure comprising first means and second means coupled for double differential detection and positioned symmetrically to provide quantities for the double differential detection in a phase shift. If the sensor deforms, due to a specifically symmetric positioning of the first and second means, the effect of the displacement is at least partly eliminated.

Abstract: An inertial force sensor of the present invention includes a detection element, a detection circuit for detecting the amount of inertia corresponding to the inertial force applied to the detection element; a first low-pass filter connected to the output side of the detection circuit; and a correction circuit for correcting the output of the first low-pass filter. The correction circuit includes a correction amount generation unit connected to the output side of the first low-pass filter; a correction amount storage unit connected to the output side of the correction amount generation unit; and a correction unit connected to the output side of the first low-pass filter and to the output side of the correction amount storage unit. The correction unit corrects an output value of the first low-pass filter based on a correction amount stored in the correction amount storage unit.

Abstract: Reliability and accuracy of a sensor are secured while adjustment cost of a sensor module is suppressed. A signal component analysis part 10 receives a signal output from a signal processing part 7 before passing through a low-pass filter 8, analyzes whether or not application of a fragile frequency with respect to a physical quantity is equal to or more than a threshold level, if the application of the fragile frequency is equal to or more than the threshold level, outputs output stop signals to output signal control parts 9, 16. The output signal control parts 9, 16 receive control signals output from the signal component analysis part 10, and outputs an acceleration signal and a physical quantity signal from which noise has been removed by the low-pass filters 8, 15 through the signal processing parts 7, 14.

Abstract: Provided is a sample fixing member for an atomic force microscope capable of reducing the drift amount of a sample during measurement. A sample fixing member for an atomic force microscope of the present invention includes a fibrous columnar structure including a plurality of fibrous columnar objects each having a length of 200 ?m or more.

Abstract: A probe apparatus and method of terminating a probe that probes a semiconductor device with a signal cable from a tester side by side at a proximal end of the probe and a distal end of the signal cable. In one embodiment, the probe apparatus includes: a chassis; a dielectric block mounted in the chassis for retaining the probe, the probe extending on the chassis from a proximal end of the probe to the dielectric block, extending through the dielectric block, and projecting from the dielectric block towards the semiconductor device at a distal end of the probe; and a terminating apparatus, mounted in the chassis, for terminating the proximal end of the probe with a distal end of the signal cable side by side.

Abstract: The formation of test probe structures is described. One test probe structure includes a tip portion and a handle portion spaced a distance away from the tip portion. The test probe structure also includes a body bend portion positioned between the tip portion and the handle portion, and an intermediate portion positioned between the body bend portion and the handle portion. The body bend portion may include a curved shape extending from the intermediate portion to the tip portion. The tip portion may be formed to be offset from a longitudinal axis defined by the intermediate portion. The test probe structure defines a length and includes a cross-sectional area that is different at a plurality of positions along the length. Other embodiments are described and claimed.

Abstract: A probe card includes a circuit board and an integrated circuit (IC) test interface. The IC test interface includes a first probe assembly, disposed on a terminal of the circuit board, and a second probe assembly, disposed on another terminal of the circuit board, wherein the first probe assembly and the second probe assembly are separated to allow being independently assembled to, or disassembled from, the circuit board. Each of the first probe assembly and the second probe assembly includes a probe base, disposed on the circuit board; a plurality of needles, which are cantilever needles; and a covering layer, for covering the plurality of needles, and fixed on a surface of the probe base.

Abstract: A method and apparatus for measuring an AC voltage. In one embodiment, the apparatus includes an AC voltage monitoring circuit, coupled to at least one AC line, for producing a digital representation of a voltage on the at least one AC line, processing the digital representation to create a data stream containing information regarding the digital representation, and coupling the data stream through an isolation device to form an output signal.

Abstract: Disclosed are an online alternating current detection device and method. The method includes the following steps: firstly fixedly connecting two sampling points to a segment of wire; amplifying the voltage difference of the sampling points to obtain a median value; subsequently rectifying and filtering and amplifying the median to obtain a direct current amplified value; then utilizing the amplified value, the median value, the multiplying power there between and the resistance value of the wire between the two sampling points to calculate an estimated value of an alternating current; comparing the estimated value to a reference value measured by a standard device between the two sampling points; then adjusting the multiplying power of the amplified value relative to the median until the estimated value coincides with the reference value, only then can the alternating current be measured online.

Abstract: A voltage sensor includes an insulator with mutually insulated electrodes embedded therein. The electrodes are coaxial and cylindrical and overlap axially along part of their lengths. They are mutually staggered and control the surfaces of electric equipotential such that there is a substantially homogeneous electric field outside the insulator and a substantially homogeneous but higher field within a sensing cavity within the insulator. A field sensor is arranged within the sensing cavity to locally measure the field. This design allows for the production of compact voltage sensors for high voltage applications.

Abstract: A method for detecting a load type is described. The method includes placing an electronic device in a forward phase mode. The method also includes operating a load at a maximum allowable level. The method additionally includes capturing a voltage waveform. The method further includes capturing a current waveform. The method also includes obtaining a voltage zero-cross based on the voltage waveform. The method additionally includes obtaining a current zero-cross based on the current waveform. The method further includes determining the load type based on the voltage zero-cross and the current zero-cross.

Abstract: The invention relates to a device for measuring the direct component of alternating current, applicable in current measuring systems where a low direct component of alternating current and a high amplitude of the alternating component of alternating current occur. The device for measuring the direct component of alternating current comprises a current-carrying wire (1) around which there is located a magnetic core (2) provided with a gap (3) in which a magnetic field sensor (4) with insulated terminals (5) is located and it comprises a shorted compensating winding (6) or (9) which is made in the form of a single turn coil placed on the core (2).