Abstract: The present invention provides systems and methods for monitoring tissue regions. In particular, the present invention provides systems and methods for detecting changes in tissue regions over a period of time. In some embodiments, the systems and methods of the present invention are used to evaluate the effectiveness of a particular treatment of a tissue region. In some embodiments, the systems and methods of the present invention provide a parametric response map approach for detecting and analyzing changes in tissue regions over a period of time to detect and monitor disease or tissue health and to monitor the impact of therapeutic interventions.

Abstract: The current invention provides an endotracheal tube fabricated with an array of electrodes disposed on an inflatable cuff on the tube. The array of electrodes includes multiple sense electrodes and a current electrode. The array of electrodes on the inflatable cuff is applied using a positive displacement dispensing system, such as a MicroPen®. A ground electrode is disposed on the tube approximately midway between the inflatable cuff and the midpoint of the endotracheal tube. The endotracheal tube is partially inserted into a mammalian subject's airway such that when the inflatable cuff is inflated, thereby fixing the tube in position, the array of electrodes is brought into close contact with the tracheal mucosa in relative proximity to the aorta. The endotracheal tube is useful in the measurement of cardiac parameters such as cardiac output.

Abstract: One embodiment of the invention includes an implantable electrode lead system that includes a series of shims stacked upon each other, a series of first components, and a series of second components connected to the series of first components through a series of connectors. One of the first components extends from one of the shims, and another of the first components extends from another one of the shims. The shims position the first components in a three dimensional arrangement.

Abstract: Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.

Abstract: A method includes storing in memory preoperative brain atlas data. Neurophysiological data is obtained intra-operatively for a plurality of known sites in a brain of a given patient to provide corresponding intra-operative neurophysiological data for at least a portion of the sites. A constrained optimization is performed to fit the pre-operative brain atlas data based at least in part on the intra-operative neurophysiological data.

Abstract: Techniques for identifying abnormal cardiac substrate, e.g., scar substrate, may be implemented, as an example, during implantation of a left-ventricular (LV) lead, e.g., for cardiac resynchronization therapy (CRT), which may enable placement of the LV lead to avoid the abnormal cardiac substrate. An example system for identifying abnormal cardiac substrate comprises at least one implantable LV lead comprising at least one bipolar electrode pair configured to sense a LV bipolar cardiac electrogram signal of LV tissue proximate the bipolar electrode pair. The system delivers cardiac pacing pulses to a left ventricle via at least one electrodes of the LV lead, which may be different then the electrodes of the bipolar pair, and which may be spaced at least a threshold distance from the bipolar pair of electrodes. The amplitude of paced depolarizations in the bipolar electrogram indicates whether tissue proximate the bipolar electrode pair comprises abnormal cardiac substrate.

Abstract: A biological signal measuring apparatus is provided. The biological signal measuring apparatus includes a first unit measurer configured to measure a first biological signal of a subject based on an electrical characteristic difference between first electrodes contacting the skin of the subject, and a second unit measurer configured to measure a second biological signal of the subject based on an electrical characteristic difference between second electrodes contacting the skin of the subject at positions different from positions of the first electrodes. A plurality of unit measurers including at least the first unit measurer and the second unit measurer are arranged based on characteristics of contact parts of the first and second electrodes.

Abstract: A wire harness for a medical device includes a wiring bundle, a distal flex circuit, and a proximal flex circuit. The wiring bundle includes a plurality of twisted pair wiring and a shield, and operatively or conductively connects the distal flex circuit to the proximal flex circuit. The distal flex circuit may be configured to operatively or conductively connect to an electrically controlled object located in a distal portion of the medical device. The proximal flex circuit may be configured to operatively or conductively connect to an electrical connector.

Abstract: This invention relates to the determination and/or representation of physiological information relating to a heart surface.

Abstract: A medical diagnostic/monitoring system is disclosed herein. The medical diagnostic/monitoring system includes a data acquisition device having a first near field communication device, and a data storage device wirelessly connected to the data acquisition device. The data storage device includes a second near field communication device. The first near field communication device and the second near field communication device are collectively configured to wirelessly transfer power and data from the data acquisition device to the data storage device.

Abstract: The present disclosure uses physiological data, ECG signals as an example, to evaluate cardiac structure and function in mammals. Two approaches are presented, e.g., a model-based analysis and a space-time analysis. The first method uses a modified Matching Pursuit (MMP) algorithm to find a noiseless model of the ECG data that is sparse and does not assume periodicity of the signal. After the model is derived, various metrics and subspaces are extracted to image and characterize cardiovascular tissues using complex-sub-harmonic-frequencies (CSF) quasi-periodic and other mathematical methods. In the second method, space-time domain is divided into a number of regions, the density of the ECG signal is computed in each region and inputted into a learning algorithm to image and characterize the tissues.

Abstract: An improved deformable carrier or connector for an implantable neural interface device is described. The neural interface device comprises a carrier supporting at least one electrode array. The carrier comprises a tubular sidewall extending from a proximal carrier portion to a distal carrier portion. At least one deformable segment is provided in the carrier sidewall. The deformable segment is more pliable than the remainder of the carrier sidewall to preferably move in response to forces imparted on the carrier and the electrode array by the shifting forces in body tissue. The deformable segment takes the form of a thinned sidewall segment or a slitted wall segment.

Abstract: The invention concerns a device for non-invasive detection of malignant processes in human body. Diagnostically informative optical data are obtained by exposing human fingertips to pulsed electric fields strong enough to initiate atmospheric pressure corona discharge. The device that provides reliable information useful for detection of cancer-specific spectral signatures comprises a transparent electrode (4) to generate electric impulses, which is covered by a rigid transparent insulator (3); a flexible transparent membrane (2) positioned loosely on the free surface of the rigid insulator to facilitate the recombination processes; a dark opaque membrane (1) positioned on the transparent membrane to eliminate spurious light; an image-receiving camera (5) mounted beneath the optically transparent electrode and a computer to operate the device and process recorded data.

Abstract: Methods are disclosed for assessing the condition of a cartilage in a joint and assessing cartilage loss, particularly in a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. The amount of cartilage tissue that has been lost, for example as a result of arthritis, can be estimated.

Abstract: Techniques for temperature measurement and correction in long-term MR thermometry utilize a known temperature distribution in an MR imaging area as a baseline for absolute temperature measurement. Phase shifts that arise from magnetic field drifts are detected in one or more portions of the MR imaging area, facilitating correction of temperature measurements in an area of interest.

Abstract: Disclosed is a method and device for detection of H. Pylori in breath emissions utilizing an unlabelled urea, in which a patient ingests a safe quantity of unlabelled urea. After ingestion, expired breath of the patient is analyzed for ammonia, with a detection based on levels of ammonia lower than 50 parts per billion to 500 ppm to detect helicobacter pylori.

Abstract: A method for generating data indicative of lung function of a subject. The method comprises receiving first data which has been obtained from the subject, and inputting said first data to a model of lung function to generate said data indicative of lung function. The model of lung function comprises a first model component modelling transfer of gaseous oxygen from a gaseous space within the lung to biological material within the lung based upon quantitative data indicative of oxygen content in the inhaled gases and oxygen content in the biological material and a second model component modelling the transfer of oxygen from the lungs by oxygenation of venous blood to create oxygenated blood based upon quantitative data indicative of oxygen content in the venous blood.

Abstract: An apparatus for evaluating leg movement characteristics of a patient is provided. The apparatus comprises a base assembly configured to at least partially support the patient's torso; and first and second leg support assemblies independently pivotably mounted about a pivot axis relative to the base assembly. Each leg support assembly is configured to at least partially support a portion of a respective one of the first and second legs, independent of the support of the torso. Each of the leg support assemblies also comprises: a first leg support member including a foot rotation assembly configured to at least partially retain and support an associated foot of the patient and to rotate it about an axis of rotation relative to the base assembly; and a second leg support member configured for supporting a portion of the leg at a location proximal relative to the first leg support member.

Abstract: A support plate with a horizontal flat standing surface carries two posts, and is rotated about a vertical axis. A stationary triangulation measuring head having a camera and a light line projector, projects light lines, which are perpendicular to the plane of the support plate, onto a person who stands upright on the standing surface of the plate. Encoded, photogrammetrically evaluatable marks are arranged on the plate around the standing surface and on the post. Images taken by the camera during rotation of the plate are transferred to a computer to determine a three-dimensional shape of the person or of part of the person. Marking-free fields are arranged on the support plate and on the post. The computer determines the parameters of the triangulation measuring head to performs a self-calibration of the detection process based on positions of the photogrammetric marks and shapes of light traces on the marking-free fields.

Abstract: There is provided a physiological detection device including a finger detection unit, a storage unit and a processing unit. The finger detection unit is configured to detect a current track drawn by a current user and current physiological information of the current user. The storage unit is configured to previously store track features of predetermined tracks drawn, for a predetermined time interval or a predetermined times on the finger detection unit, by a plurality of users and each of the track features is associated with one of the users. The processing unit is configured to analyze the current track and identify the current user according to the track features in the storage unit. There is further provided a physiological detection method and a user identification method.

Abstract: A device for personal identification using a dorsal band vein-pattern in preferable configuration is disclosed. The device utilizes an on-board or external camera using wired or wireless communication operating in both visible and near infrared range, a memory unit, a processor and Speeded-Up Robust Features algorithm for image acquisition, processing and comparison against the existing database of hand vein-pattern images. The matching criterion between the images to be used for the person's authentication. Device can optionally use wireless connection for image transferring and processing.

Abstract: Multi-lancet unit for a lancet device. The unit includes a plurality of lancets arranged in a row. Each lancet has a front end, a needle which extends from the front end, and a rear end. The front end of at least one of the plurality lancets is removably connected to the rear end of another of the plurality of lancets. The lancet device utilizes the multi-lancet unit and includes a body and a holding member which houses the multi-lancet unit. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Abstract: The invention concerns a control device for a medical test system which has a lancing element that can be inserted into body tissue to collect body fluid and a lancing drive for the lancing element. A sensor element for body fluid is arranged on the lancing element and a control unit is coupled to the sensor element for detecting a fault when collecting body fluid. In order to improve the success rate, the control unit actuates the lancing drive for an automatic puncture repetition in less than 1 second when a fault, e.g., inadequate wetting of a detection field, occurs.

Abstract: An orthopedic system to monitor a parameter related to the muscular-skeletal system is disclosed. The orthopedic system includes electronic circuitry, a sensor, and a remote system to monitor and measure. The sensor is configured to measure color or turbidity. The electronic circuitry is coupled to and interfaces with the sensor. The electronic circuit includes a transmitter to transmit measurement data from the sensor to the remote system. The orthopedic system is configured to monitor color or turbidity of a fluid in proximity to the muscular-skeletal system. The orthopedic system can transmit a signal when a predetermined color is detected or when the turbidity of the fluid exceeds a predetermined value. Alternatively, the remote system includes a processor and software configured to analyze the measurement data from the sensor and transmit a signal when a predetermined color is detected or when the turbidity of the fluid exceeds a predetermined value.

Abstract: Generally, methods, devices, and systems for generating a hybrid analyte level output are provided. The uncompensated analyte levels lag in time with respect to the lag-compensated analyte levels, and the hybrid analyte level output tracks between the uncompensated analyte levels and the lag-compensated analyte levels according to predetermined criteria.

Abstract: In general, the invention is directed to methods and devices for determining an ion concentration in the extracellular fluid of a patient. As examples, the ion may be one or more of potassium, sodium, chloride, or calcium. A system includes an electrode deployed in or near a tissue, such as a skeletal muscle, of the patient. A pulse generator supplies one or more stimulations to the tissue, and a sensor, such as an accelerometer, detects the response of the tissue to the stimulations. A processor determines a concentration of ions in the extracellular fluid as a function of the response. The system may detect an ion imbalance based upon the determined concentration of ions.

Abstract: A biological information monitoring apparatus includes: an acquiring section configured to acquire biological information of a patient; a storage section configured to store a threshold which is changed with time from a first time; and a determining section configured to compare the biological information acquired by the acquiring section with a threshold corresponding to a second time when the biological information is acquired by the acquiring section, to perform determination of an abnormality of an living body of the patient.

Abstract: A method and an apparatus to analyze two measured signals that are modeled as containing desired and undesired portions such as noise, FM and AM modulation. Coefficients relate the two signals according to a model defined in accordance with the present invention. In one embodiment, a transformation is used to evaluate a ratio of the two measured signals in order to find appropriate coefficients. The measured signals are then fed into a signal scrubber which uses the coefficients to remove the unwanted portions. The signal scrubbing is performed in either the time domain or in the frequency domain. The method and apparatus are particularly advantageous to blood oximetry and pulserate measurements. In another embodiment, an estimate of the pulserate is obtained by applying a set of rules to a spectral transform of the scrubbed signal. In another embodiment, an estimate of the pulserate is obtained by transforming the scrubbed signal from a first spectral domain into a second spectral domain.

Abstract: The subject matter disclosed herein relates to systems, methods and/or devices for calibrating sensor data to be used in estimating a blood glucose concentration. A relationship between sensor measurements and reference readings may be used to estimate a relationship between sensor measurements and blood glucose concentration. Such sensor measurements may be weighted according to a decreasing function of uncertainty associated with sensor values.

Abstract: Some embodiments provide a system for synchronizing and configuring monitoring devices. In some embodiments, a patient monitoring device settings module is configured to automatically provide configuration settings to a plurality of patient monitoring devices. A monitoring device data module is configured to receive measurement data from at least one of the patient monitoring devices. An electronic medical records system interface is configured to provide patient data at least partially derived from the received measurement data to an electronic medical records system. A patient records interface is configured to provide patient data to at least one of the patient monitoring devices.

Abstract: An apparatus for eliciting a blood sample is presented having a lancet for lancing a body part of a user and a cleaning member of absorbent material operable to clean a surface of the body part, the apparatus being configured such that in use the lancet is moved to lance a body part of a user and subsequently the cleaning member is moved to contact the body part of the user so as to remove blood from the surface of the body part prior to collection of the blood sample from the surface of the body part.

Abstract: The invention relates to a device for measuring the pinch force between a person's thumb and index finger, comprising: first and second parallel blades, said blades being disposed at a distance from one another and embedded at a first longitudinal end thereof; a sensor for measuring the pinch force exerted between the two blades at the second longitudinal end thereof, perpendicularly to the respective main planes thereof; a means for displaying the pinch force; and a means for storing and/or processing the pinch force. According to the invention, the first blade forms part of a rigid parallelepiped frame and the second blade is disposed in the space inside the parallelogram.

Abstract: The present invention relates to a portable device which analyzes cervical tissue using two simultaneous measurements, namely an electrical measurement and an optical measurement. The aforementioned device examines different areas of cervical tissue, taking electrical measurements from same in different frequency ranges and optical measurements in three different wavelengths. Once the measurements have been obtained, they are processed by a configurable device or microcontroller in accordance with mathematical formulae obtained from multiple measurements taken from healthy and cancerous tissues. Three possible responses can be obtained from the processing of the measurements: healthy tissue, cancerous tissue or the presence of human papilloma virus. The inventive device can be used as a self-detection device since it is equipped with an attachment for positioning same upon detection of proximity to the cervix in order to take a correct measurement.

Abstract: A laser catheter with a pressure sensor is provided according to embodiments of the invention. The pressure sensor may be coupled with the distal end of the laser catheter and may comprise any of various piezoelectric materials, for example Polyvinylidene Difluoride (PVDF). In various embodiments of the invention the pressure sensor is configured to detect pressure longitudinally and coaxially. The pressure sensor may provide an electric potential that is proportional to the vessel pressure and may be used to monitor and/or adjust laser parameters. In other embodiments the results from the pressure sensor may be used to determine the vessel size and/or the type of material being ablated.

Abstract: A feedback device for measuring balance related information, and for producing a stimulation of the skin that encodes that information in a way that is useful to the wearer of the device. At least one sensor detects balance information and transmits at least one balance information signal to a signal processing subsystem. The signal processing subsystem converts the received balance information signal into at least one stimulation control signal. The signal processing subsystem then transmits the stimulation control signal to at least one stimulator, which provides stimulation to a wearer of the device reflecting the stimulation control signal received from the signal processing subsystem.

Abstract: A monitoring device configured to be attached to the ear of a person includes a base, an earbud housing extending outwardly from the base that is configured to be positioned within an ear of a subject, and a cover surrounding the earbud housing. The base includes a speaker, an optical emitter, and an optical detector. The cover includes light transmissive material that is in optical communication with the optical emitter and the optical detector and serves as a light guide to deliver light from the optical emitter into the ear canal of the subject wearing the device at one or more predetermined locations and to collect light external to the earbud housing and deliver the collected light to the optical detector.

Abstract: Systems and methods are provided for classifying an impact to a head of a human being as one of a plurality of event classes. A sensor interface is configured to determine an acceleration at a location of interest on the human being from provided sensor data in response to the impact. A feature calculation component is configured to calculate a plurality of impact parameters from the determined acceleration at the location of interest. A pattern recognition classifier is configured to associate the impact with an associated event class of at least three associated event classes according to the calculated plurality of impact parameters. A post-processing component is configured to communicate the associated event class an observer via an associated output device.

Abstract: There is provided a sensing device comprising an electromagnetic wave emitter for emitting electromagnetic waves to a surface; an electromagnetic wave detector for detecting the emitted electromagnetic waves that are reflected from the surface; and a force transmitting member configured to transmit a force applied thereto for detection, wherein the force transmitting member is positioned relative to the electromagnetic wave emitter and electromagnetic wave detector to substantially prevent waves emitted by the electromagnetic wave emitter from travelling directly to the electromagnetic wave detector.

Abstract: A biological signal measuring apparatus is provided. The biological signal measuring apparatus includes a receiving unit configured to receive a biological signal from each of unit measurers arrayed on a subject's skin, and configured to receive a noise signal that is a common component of electrical characteristics, and a noise filtering unit configured to filter noise from a first biological signal between first electrodes of a first unit measurer among the unit measurers, by using a second noise signal between second electrodes of a second unit measurer among the unit measurers. The biological signal corresponds to a difference between the electrical characteristics of electrodes of each of the unit measurers.

Abstract: Methods, devices, and kits are provided for mitigating single point failure of at least one device in an analyte monitoring system.

Abstract: A medical imaging system includes a first x-ray image detector, a first x-ray generator, and a motorized turntable. The first x-ray image detector and the first x-ray generator are each mounted on a base and positioned opposite each other such that x-rays are projected from the first x-ray generator to the first x-ray image detector through a first imaging volume. The motorized turntable is positioned below the first imaging volume and between the first x-ray image detector and the first x-ray generator and is configured to rotate an imaging subject within the imaging volume.

Abstract: Disclosed is a patient support apparatus having a patient support couch, a moveable support plate for supporting a patient, a surgical head fastening unit for fastening a head of the patient in an examination position and/or in an operation position. The patient support apparatus includes a marker unit for marking a maximum occupancy area for the surgical head fastening unit.

Abstract: Disclosed is a radiographic imaging system which is provided with: a plurality of radiographing chambers equipped with a registration device; a console; and a management device for associating and managing the identification information of a portable radiographic imaging device with the identification information of the radiographing chambers. When the identification information of the portable radiographic imaging device is notified by the registration device of a radiographing chamber, the console displays an icon corresponding to the imaging device on a selection screen. When the identification information of the portable radiographic imaging device, as notified by the registration device, is associated with the identification information of another radiographing chamber, the management device discards the association and deletes the icon corresponding to the portable radiographic imaging device from the selection screen of the console, which is associated with said other radiographing chamber.

Abstract: Methods and related systems provide an interactive user interface in which CAD results are displayed in such a way that they may be used for both interpretation of detected abnormalities and for avoiding perceptual oversights. The output of a (multi-view) computer aided detection system is presented to the reader of a screening case in two phases: (1) an interactive phase, and (2) a prompting phase. In the first phase the reader can probe image locations for CAD information. In the second phase regions identified as relevant by the CAD system and not yet probed by the reader are prompted or displayed to the user, as these may have been overlooked by the reader. The CAD results can be calibrated to a probability of malignancy.

Abstract: Embodiments of methods and/or apparatus for a radiographic imaging system can include a radiographic detector including an image receptor to receive incident radiation and generate uncorrected electronic image data; a storage device to store calibration data at the detector, and a processor to generate calibration-corrected image data from the uncorrected electronic image data and the calibration data. The calibration-corrected image data can be further processed by the processor to perform image processing before transmitting a corrected image (e.g., DICOM image) to the radiographic imaging system. The detector can further include a display to display imaging system controls or the corrected image.

Abstract: A novel ultrasound device for needle procedures is disclosed that comprises a needle with an integrated ultrasound transducer. The transducer may be part of a drop-in, self contained beacon unit that fits within the needle shaft. The transducer may alternatively include electrical leads connectable to an electrical subsystem housed within an adapter that is connectable to a handle. Alternatively, the electrical subsystem may be housed within a handle connectable to the needle by a bayonet-mount configuration, a slide-and-click configuration, or a cartridge configuration. The electrical subsystem is preferably configured to control when the transducer emits an ultrasound pulse. The handle may include all or part of a vacuum means for applying negative pressure to tissue disposed near a tissue sample aperture.

Abstract: An ultrasound diagnostic apparatus includes a monitor simultaneously displaying in blocks a series of examination items on an ultrasound diagnosis within a screen in chronological order and a controller causing the monitor to highlight a block of an examination item being currently executed among blocks indicating the series of examination items displayed on the monitor.

Abstract: An ultrasound imaging probe includes a housing (202) having a long axis and an elongate tubular shaft (214) including an internal cavity and first and second end portions (218, 220). The shaft extends along the long axis and is rotatably supported in the housing for rotation relative to the housing through an angular range including one hundred and eighty degrees to a predetermined maximum angle. The probe further includes a transducer array (222), including a plurality of transducer elements along the long axis, affixed to the first end portion (218) of the shaft. The probe further includes an electrical connector (228) fixedly mounted in the housing. The probe further includes an physical electrical pathway (226) having first and second ends and extending along and in the internal cavity of the shaft, wherein a first end of the pathway is connected to transducer array and a second end of the pathway is connected to the electrical connector.

Abstract: An ultrasound transducer and methods of fabricating and using the ultrasound transducer. The ultrasound transducer includes a composite layer having a first surface and comprising a plurality of piezoelectric elements separated by isolating material filled kerfs. The composite layer is configured so that the first surface includes an exposed face of each element of the plurality of piezoelectric elements. The transducer further includes a plurality of electrodes defined on the first surface, the electrodes having boundaries configured so that none of the exposed faces are in contact with more than one of the plurality of electrodes. The electrodes may be defined in a conductive layer deposited on the first surface of the composite body by forming a channel in the conductive layer that is aligned vertically with the dielectric kerfs. The transducer may be used to scan a treatment region with both HIFU and imaging ultrasound signals.

Abstract: An ultrasound diagnostic apparatus includes a monitor displaying an ultrasound image, an operating unit receiving an operating instruction from an operator and a control unit controlling a diagnostic apparatus body. The control unit causes measurement calipers each having a measurement line extending linearly in a vertical direction and a gate portion including an upper gate line and a lower gate line which are disposed parallel to each other on the measurement line to be displayed in a superimposed manner on the ultrasound image displayed on the monitor based on the operating instruction from the operating unit, and measurement is sequentially performed at more than one measurement site using the gate portion of each of the measurement calipers which is capable of rotation and change of the distance between the upper gate line and the lower gate line.