Abstract: A control system (23) is arranged to control the operation of an apparatus (200) for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (C) for connecting the blood circuit (20) to the vascular system of a patient. The blood circuit (20) comprises a blood processing device (6), and at least one pumping device (3). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit (20) to pump blood from the vascular system via the connection system (C) through the blood processing device (6) and back to the vascular system via the connection system (C). The control system (23) is operable to obtain measurement data from at least one energy transfer sensor (40) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (20).

Abstract: In one embodiment, an exsanguination preventing device includes a collection container having an inlet configured to receive blood from a patient and an outlet configured to discharge the blood; a pump operatively coupled to the collection container; a conduit fluidly coupled to the collection container, which receives the blood from the collection container, the blood being moved by the pump; and an insertion device, which delivers the blood from the conduit to a bodily part of the patient. The collection container is configured to be sealingly coupled to a wound on the patient and air entrapped within the exsanguination preventing device is removed by an air removal system, such to prevent unwanted discharge of air into the bodily part of the patient. All the components of the exsanguination preventing device are sized such to make it portable in a pocket of a garment or backpack of a soldier.

Abstract: A assembly for nasal irrigation for the handheld irrigation of a user's nasal cavity comprising a housing with a refill chamber containing irrigating fluid, an applicator, an actuator for forcing irrigating fluid from the refill chamber through the applicator into the user's nasal cavity during operation, and a solution port for refilling the refill chamber. Some embodiments of the present invention may further comprise a system for nasal irrigation that includes the assembly for nasal irrigation or handheld irrigator, as well as a solution assembly structured for dispensing irrigating fluid to the handheld irrigator, a docking station for removably housing the handheld irrigator, a solution assembly and a refill control, including a check valve.

Abstract: An ambulatory medical device is presented. The ambulatory medical device comprises a function module to provide the intended functionality of the device, a controller module to control the device, a sound generation module with an acoustic transducer to produce an acoustic signal and a signal generator to drive the acoustic transducer with a certain frequency. The signal generation module is arranged within a housing of the device. A tuning module varies the frequency used by the signal generator to drive the acoustic transducer and determines one or more frequencies that correspond to an optimum sound level of the acoustic signal outside of the housing of the device. The optimum sound level of the acoustic signal is a maximum sound level outside of the housing of the device, and/or a maximum perceivable sound level as determined by a user.

Abstract: Tank (11) for a drug infusion device (41), comprising a hollow cylindrical body (13) provided at its front with an opening (15) for the passage of the drug and in its inside with a plunger (25) slidable within the tank for drawing in and/or injecting the drug through said opening, said tank being provided at its rear with a coupling part for ensuring the mechanical connection of the tank (11) with a complementary coupling part provided in the infusion device (41), said coupling parts defining together a bayonet-like connection coupling, said coupling part of the tank (11) being housed inside the cylindrical body (13).

Abstract: An apparatus for the detection of extravasation of an injection fluid infused into a tissue during an imaging procedure is disclosed. The apparatus includes at least a first source of energy to supply an X-ray or gamma ray imaging energy to tissue in the vicinity of a site and at least a first sensor to measure an energy signal resulting from the energy supplied to the tissue by the first imaging energy source, and circuitry configured to compare the energy signal detected by the first sensor to a baseline measurement and provide an alert that extravasation is occurring.

Abstract: This pharmaceutical injection device comprises a main body case; a pharmaceutical syringe mounting portion provided inside the main body case; a piston that is provided so as to be movable with respect to a pharmaceutical syringe that is removably attached to the pharmaceutical syringe mounting portion; a drive mechanism for driving the piston; a controller that is electrically connected to the drive mechanism; and an acceleration sensor that is connected to the controller. When a manual mixing mode of the pharmaceutical syringe is selected, the controller changes to the next step (air venting mode) if the inclination angle of the main body case sensed by the acceleration sensor is greater than a specific value.

Abstract: A drive device of an infusion syringe piston drive head for moving an infusion syringe piston is described. The device includes an advancing means including an advancing slide, an advancing spindle and a multi-part advancing spindle nut having at least one radially movable nut shell, and a blocking means adapted to be automatically triggered by a control sensor for blocking an infeed motion of the drive head in which the advancing slide is drivable by the advancing spindle nut at the advancing spindle and in which the drive head is arranged at the advancing slide, wherein the blocking means adapted to be automatically triggered by a control sensor includes the multi-part advancing spindle nut for blocking the infeed motion of the drive head on the advancing spindle.

Abstract: An embodiment of the invention is directed to a bone marrow aspiration device comprising a plurality of syringes, each of which operates in a series of sequential steps to obtain bone marrow of high quality and therapeutic value, i.e., having a high MSC/ml number. An embodiment of the invention preferably comprises three syringes, wherein a first syringe is used to aspirate bone marrow from a subject, a second syringe contains an anticoagulant, and the third syringe contains a mixture of the bone marrow aspirate and the anticoagulant.

Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes an annular groove formed in a distal end and adapted to receive a circlip disposed in a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.

Abstract: The present invention relates to a finger-grip device designed to be placed on the flange of a cylindrical barrel of a medical syringe or cartridge, increasing the contact surface with the fingers of the operator during the injection or withdrawal of fluids to or from a patient, characterised in that it does not stop or hinder the run of the plunger within the cylindrical barrel.

Abstract: A syringe assembly including a plunger rod having a first end, a second end, and a rod portion extending therebetween, wherein at least a portion of the rod portion is flexible is disclosed. The flexible portion of the rod portion allows a stopper to be moved between a first position and a second position within a syringe barrel while the overall length of the syringe assembly remains the same throughout the movement between the first position and the second position. In another embodiment, a syringe assembly including a restraining member adapted to communicate with the flexible portion of the rod portion such that movement of the first end of the plunger rod in a first direction actuates movement of the second end of the plunger rod in a second direction different than the first direction is disclosed.

Abstract: A stopper adapted for attachment with a plunger rod for use within a syringe barrel includes a main body portion defining an open rearward end configured to receive the plunger rod. The main body portion is manufactured from a rigid or semi-rigid polymeric material having an elastic modulus in the range of about 0.01 GPa to about 5 GPa. When fluid pressure is increased inside the syringe barrel during an injection, at least one of the following actions occurs: a) a flexible roof of the main body portion expands in a radial direction toward an inner wall of the syringe barrel; b) a first perimetrical skirt extending around an outer circumference of the main body portion is forced against an inner wall of the syringe barrel; and c) an engagement between the plunger rod and an engagement portion provided along an inner circumference of the main body portion.

Abstract: A medical delivery system comprising a container which is adapted to be fastened to a dosing assembly. One of the container and the dosing assembly comprises a rotatable element adapted to cooperate with the other one of the container and the dosing assembly, so as to lock/fasten the container to the dosing assembly. Furthermore, the present invention relates to a container and a dosing assembly for use in the medical delivery system.

Abstract: The present invention relates to an electronically assisted injection device adapted to inject doses of a drug from a held cartridge. The injection device may include a first rotational sensor (40) coupled to a driver (6) for sensing a dose setting and a second rotational sensor (50) coupled to a dosing member (8) for sensing an expelled dose. A third axial sensor (60) provides information relating to the axial position of the driver (6). A control circuit is adapted to determine the end of dosed state based on data from the first, the second and the third sensors (40, 50, 60). The injection device may also include an arrangement for determining fluid ingress into the interior of the injection device. The arrangement includes an electrically non-conductive surface portion (63) disposed on a first component (6) and an electrode assembly (62a, 62b, 62c) disposed on a second component (80) wherein the first component (6) and the second component (80) moves relative to each other during operation.

Abstract: A drive assembly for a drug delivery device, comprising a housing with a proximal end and a distal end, and a longitudinal axis (A) extending between the proximal end and the distal end, a rotation sleeve being rotatable relative to the housing, and a piston rod being axially moveable relative to the housing. The piston rod is in mechanical cooperation with the rotation sleeve to be rotatable and moveable in the distal direction relative to the housing when the rotation sleeve rotates in a first direction (D1) and to be stationary in axial direction relative to the housing when the rotation sleeve rotates in a second direction (D2) opposite to the first direction (D1).

Abstract: A dosing mechanism for use with an injection device to adjust a dose to be discharged from the injection device, the dosing mechanism including an adjusting element which can be moved relative to the dosing mechanism and including a coupling element for being releaseably coupled to a threaded bar associated with the injection device such that the adjusting element can be moved relative to the bar in one direction while a relative movement in the opposite direction is prevented, the dosing mechanism further including a retaining element with an engaging element for preventing the bar from being rotated in at least one direction, and a releasing element for uncoupling the adjusting element and bar.

Abstract: Methods and apparatus are disclosed for disposing a valve within a barrel of a conventional syringe to provide, first, a mixing syringe embodiment and, second, a sequential delivery syringe embodiment. Generally, the valve divides the syringe barrel into a proximal and a distal chamber. When used for mixing, the valve is self-displaceable by expansion of decompressing matter disposed within the valve against exterior matter permitting proximal displacement of the valve independent of character of matter in the distal chamber. For sequential delivery, switching of the valve occurs after switch opening causing pressure is relieved, thereby reducing inadvertent uncontrolled flow when the valve opens. In addition, a combination mixing and flush syringe is disclosed whereby a mixing and a flush capability is provided within a conventional syringe.

Abstract: The invention relates to a syringe (20) comprising a syringe barrel (15), an ejector unit (25) arranged at the distal end of the syringe barrel (15) with a plunger rod (17), a coupling part (37) and a plunger (16) and a syringe head (21) arranged at the proximal end of the syringe barrel (15) with a needle unit (12) which is arranged in a guide sleeve (5) and is slidable therein with a cannula (3) and a cannula holder (4) and a pinion (2), by means of which the needle unit (12) is axially movable, relative to a syringe barrel (15) from a rest position to an actuation position. At the distal end of the guide sleeve (5) a sealing element (7) is arranged. The pinion (2) has at least one guide knob (1), which can be brought into engagement optionally with one of two slide tracks (10) provided in the guide sleeve (5), wherein the slide tracks (10) are inclined in opposite directions.

Abstract: A blister piercing element for puncturing the lid of a blister containing a dose of medicament for inhalation by a user. The piercing element has an outlet opening for the passage of medicament entrained in an airflow out of the blister and, a piercing head extending beyond and overhanging the opening that cuts a flap in a lid of a blister and pushes it away from the opening during insertion.

Abstract: The disclosure relates to a medical dispenser, comprising an outlet and a plurality of sealed compartments containing medicament to be sequentially aligned with and dispensed through said outlet. Movement of an actuator sequentially causes mechanical energy to be built up and then released and converted into an indexing movement of the compartments. The disclosure also relates to an indexing method for a medical dispenser.

Abstract: Described is a system including an air pressure supply arrangement, a sensor and a titration device. The air pressure supply arrangement provides air pressure to a patient's airways. The sensor detects input data corresponding to a patient's breathing patterns of a plurality of breaths. The titration device receives and analyzes the input data to determine existence of breathing disorder and corresponding characteristics. The titration device generates output data for adjusting the air pressure supplied to the patient as a function of an index of abnormal respiratory events included in the input data.

Abstract: An inflatable balloon cuff may be adapted to seal a patient's trachea when associated with an endotracheal tube. Configurations of these cuffs that include tapered regions with certain characteristics, such as cuff wall diameter and thickness, may provide improved sealing of the trachea.

Abstract: A venturi connector includes a housing having a mixing chamber defined therein and at least one window that is in fluid communication with the mixing chamber and is open to atmosphere to allow air to be entrained into the mixing chamber. The connector includes a nozzle actuator member includes a body having a plurality of discrete nozzles formed therein. The nozzles are defined by different sized venturi orifices through which gas flows, thereby allowing the concentration of the gas delivered to the patient to be varied. The nozzle actuator member is disposed within one window formed in the housing between the gas port and the mixing chamber such that the position of the nozzle actuator member within the housing can be adjusted so as to position one of the discrete nozzles into the gas flow path, thereby controlling the flow rate of the gas into the mixing chamber and ultimately the concentration of gas delivered to the patient.

Abstract: A breathing apparatus has a first delivery device for adding a volume of a substance to a gas flow, the delivery device having a gas inlet and a gas outlet. A unit monitors a presence of the substance in a gas downstream the delivery device using a first sensor unit at the gas outlet that provides a first measurement value based on an acoustic property of a gas in a first conduit. A second sensor unit at the gas inlet provides a second measurement value based on an acoustic property of a gas present in the second conduit. A control unit determines the presence of the substance based on the first measurement value or based on a comparison of the first measurement value and the second measurement value.

Abstract: A breathing circuit system for supplying a breathable gas from a breathable gas supply system to a patient interface. The system comprises a heated conduit, comprising a hose and a hose heating system associated with the hose, and a plurality of adapter elements. The hose heating system is provided for operating within a first predetermined voltage range. A controller is associated with the breathing circuit and provides voltage within a second predetermined voltage range. Each adapter element comprises at least one electric component provided for adjusting the voltage supplied by the controller from a second range to the first range.

Abstract: Breathing assistance apparatus includes a gases supply unit adapted to, in use, deliver a stream of pressurised gases from an outlet. The gases supply unit is adapted to vary the pressure of the stream of pressurised gases. A supply path includes a flexible self-supporting gases transportation pathway having a first end connected to the outlet so that the gases transportation pathway receives the stream of gases and conveys the gases to a patient. A patient interface is connected to the second end of the gases transportation pathway receives a stream of gases. At least one sensor measures at least one information parameter of the supply path. A control system associated with the gases supply unit receives the information parameter. The control system contains reference data, and compares the received data to reference data, and determines a supply path based on the comparison.

Abstract: A system for providing humidification to gas to be provided to a patient to support breathing including: a humidification component configured for adding water vapor to the gas; and a humidification component controller coupled with the humidification component and configured for receiving humidification target value information, the humidification component controller including: a humidification target value determiner configured for determining, based on received humidification target value information, a humidification target value of at least two possible humidification target values, the humidification target value identifying a humidification level setting corresponding to the patient.

Abstract: A ventilation air pressure oscillation mitigation device for a ventilator includes a housing defining an inlet and an outlet. The device includes a valve seat defining a primary opening and a plurality of secondary openings. A valve body is selectively positionable in a first position and a second position within the device. In the first position, substantially all of a first flow of ventilation air from the inlet to the outlet passes through the primary opening. When the valve body is in the second position, all of a second flow of ventilation air from the inlet to the outlet passes through the plurality of secondary openings. An actuator controls a position of the valve body.

Abstract: An LED lamp comprising a housing, a drive circuit, and a plurality of LED dies driven by the drive circuit, The plurality of LED dies may be in a ratio of at least one of 15 mint LED dies to 5 hyper red LED dies to 4 blue LED dies and 1 mint LED die to 1 hyper red LED die to 1 blue LED die. The drive circuit may operate the LED dies such that a relative peak intensity of the blue LED dies is within the range from 80%-90% or 90%-100% of a peak intensity of the hyper red LED dies, and a relative peak intensity of the mint LED dies is within the range of 50%-60% or 30%-40% of the peak intensity of the hyper red LED dies.

Abstract: A catheter has an entrance opening defined by the first end of a catheter body and non-smooth inner surface. The entrance opening intersects a longitudinal axis extending longitudinally through the center of a lumen adapted to drain urine from a bladder. The non-smooth inner surface can have dimples, channels, or grooves, all of which decrease frictional fluid forces against the inner surface as the urine drains. The catheter is free of any eyelets formed in the side wall of the catheter body. The catheter is further free from any hemispheric tip located at one end.

Abstract: Catheter having a proximal section and a distal section. The proximal section having at least a delivery lumen and a guidewire receiving lumen, the guidewire receiving lumen having a proximal guidewire exit port at a location proximal of the distal end of the proximal section. A reinforcing tubular member located in the proximal section delivery lumen extending from substantially the proximal end of the proximal section to a point distal to the proximal guidewire exit port, wherein the reinforcing tubular member transitions from relatively rigid to relatively more flexible from a proximal point to a distal point thereon and has an outer diameter equal to about the inner diameter of the delivery lumen for at least a portion of the reinforcing tubular member that extends distal to the proximal guidewire exit port. The distal section having at least a delivery lumen and a guidewire receiving lumen.

Abstract: A catheter system for accessing the central venous system through an occlusion in the neck region.

Abstract: For position sensors, e.g., a fiber-based system, that build a shape of an elongated member, such as a catheter, using a sequence of small orientation measurements, a small error in orientation at the proximal end of the sensor will cause large error in position at distal points on the fiber. Exemplary methods and systems are disclosed, which may provide full or partial registration along the length of the sensor to reduce the influence of the measurement error. Additional examples are directed to applying selective filtering at a proximal end of the elongated member to provide a more stable base for distal measurements and thereby reducing the influence of measurement errors.

Abstract: The invention relates to a needle guard for use in a medical device, in particular for use in a catheter device, including a base portion having a needle passage extending in an axial direction from a proximal side of said base portion through said base portion to a distal side of said base portion wherein a needle shaft having a principle outer profile can be movably arranged in said needle passage; first and second arms extending substantially in said axial direction from said distal side of said base portion, wherein said first arm has a distal region and a proximal region; and a distal wall transversely arranged at said distal region of said first arm. The invention further relates to a catheter apparatus including such a needle guard and a needle.

Abstract: Methods and devices for treating obesity are provided, and more particularly, methods and devices for performing gastric bypasses are disclosed. In one exemplary embodiment a gastric bypass procedure is provided that includes forming a gastro-entero anastomosis between a stomach and an intestine and forming an entero-entero anastomosis between a portion of the intestine distal to the gastro-entero anastomosis and a portion of the intestine proximal to the gastro-entero anastomosis. A surrogate path is formed between the esophagus and the gastro-entero anastomosis to at least partially direct fluid from the esophagus to the intestine by way of the gastro-entero anastomosis, thereby bypassing the stomach. A variety of devices that are particularly useful in gastric bypass procedures are also disclosed. The devices include anastomotic devices that can be coupled to or integrally formed with a shunt. The devices can include a plurality of tubular bodies that are configured to have an adjustable length.

Abstract: Medical devices, as well as methods of treatment and manufacturing such devices, are provided for applying vascular therapy locally within the body vessel. The medical devices include an expandable tubular frame and a sleeve or graft material. The medical devices can be used for local delivery of a therapeutic agent within a body vessel or a tamponade for a lacerated body vessel, while simultaneously allowing perfusion of fluid or blood flow distal of the implanted medical device. The tubular frame of the medical device may have a proximal non-expanding portion and a distal self-expanding support structure. The self-expanding support structure can expand radially outward to urge the graft material to contact the wall of the body vessel. In the expanded configuration, a portion of the device allows fluid flow to continue while the sleeve is against the body vessel wall.

Abstract: A method for use with a balloon catheter device that includes a selectively bendable portion with a balloon disposed thereon, a control device for controlling bending of the selectively bendable portion, and a camera located at an end of a distal portion, includes inserting the distal portion into the nostril while the distal portion is straight; viewing an image provided by the camera; stopping insertion of the distal portion after the ethmoidal bulla is viewed in the image; articulating the distal portion in an upward direction to view the opening to the frontal sinus ostium or a downward direction to view the opening to the maxillary sinus ostium using the control device; inserting the distal portion into the frontal sinus ostium or the maxillary sinus ostium while the distal portion remains in the bent position; and inflating the balloon in the frontal sinus ostium or the maxillary sinus ostium.

Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.

Abstract: Drug delivery devices responsive to at least one external stimulus are described, along with methods for their preparation and use. The devices can be configured to respond to the stimulus, providing “on demand” release of one or more deliverables such as pharmaceutical drugs.

Abstract: A compressed article of hygiene is formed by a compressed cloth that has been compressed by dehydration or vacuum pressure into a coin shape and that is expandable upon contact with a liquid, and a plurality of microencapsulated beads containing a material. The microencapsulated beads are attached and embedded in the compressed cloth. Upon contact with water, expansion of the compressed cloth is unconstrained, and the compressed cloth when expanded has a shape of a facial mask with openings for eye, nose and mouth. The material is a facial treatment material that hardens upon drying.

Abstract: An implement for applying a volume of liquid to a treatment surface includes a support onto which is mounted a receptacle. The receptacle defines a reservoir space which receives the liquid. The receptacle includes a wall having a working surface that is used to spread the liquid over the treatment surface. The wall is resiliently deformable such that in use the working surface maintains contact with the treatment surface when spreading the liquid. The implement is used in applying a transdermal lotion to the axilla area of a user. A system for transdermal administration of a physiological active agent from a liquid composition and a method of conducting the same are also provided.

Abstract: Luer connector including a primary Luer male connector, having a secondary female section extending from a top distal part of the primary Luer male connector back towards a proximal part thereof, the primary Luer male connector including a first inner fluid flow channel extending from a proximal end thereof to the secondary female section, the primary Luer male connector being configured to mate with a primary Luer female connector having a secondary male section including a second inner fluid flow channel.

Abstract: A connector against contrary flowing for medical treatment, as to its structure, it includes a connecting seat to connect with a transmitting pipe, an insertion connecting cap fixed on the connecting seat for insertion of an external connecting terminal and a needless injection cylinder, and an elastic valve plug provided between the connecting seat and the insertion connecting cap, when the injection cylinder is pulled out of the insertion connecting cap, the elastic valve plug can impede the reverse pressure generated by the transmitting pipe (or the connecting seat), in order to avoid generating reverse flow of blood of a patient to reduce pain.

Abstract: Luer connector including a primary Luer male connector, having a secondary female section extending from a top distal part of the primary Luer male connector back towards a proximal part thereof, the primary Luer male connector including a first inner fluid flow channel extending from a proximal end thereof to the secondary female section, the primary Luer male connector being configured to mate with a primary Luer female connector having a secondary male section including a second inner fluid flow channel.

Abstract: A peelable lid system includes a peelable lid, a seal configured to seal the peelable lid to a container, a handle coupled to the peelable lid, and a lifting mechanism coupled to handle. The lifting mechanism can be coupled to the peelable lid at a plurality of attachment points, including at least one attachment point coupled to the peelable lid away from the handle. The lifting mechanism can be configured to lift at least one portion of the peelable lid near each of the plurality of attachment points.

Abstract: An embodiment includes simultaneously supplying direct current (DC) energy to recondition cartilage of a knee joint while simultaneously protecting that cartilage by supplying alternating current (AC) energy to stimulate muscle tissue contralateral to the cartilage to at least partially decompress the cartilage and at least partially support the joint. Other embodiments are described herein.

Abstract: Systems, apparatuses, and methods for differentiating between multiple leads that are implanted within a patient include a stimulator configured to be implanted at an implant site within the patient and generate electrical stimulation current, a plurality of leads each comprising one or more electrodes configured to deliver the electrical stimulation current at a stimulation site within the patient, and a shuttle assembly having a plurality of receiving ports each configured to receive a proximal portion of one of the leads and guide the leads from the stimulation site to the implant site of the stimulator. The shuttle assembly is configured to enable a user to differentiate between each of the leads after the leads are guided to the implant site of the stimulator.

Abstract: An electrical lead system includes a shaft to which a series of expandable ring electrodes are attached that follows the contour of the vascular or muscular structures of the heart, such as cardiac veins, arteries, atrial appendages and trabeculae, and provides sensing of electrical cardiac impulses, pacing and high voltage shock or defibrillation. The lead system uses a variety of energy sources to stimulate the heart, such as ultrasound, electromagnetic and electric impulses.

Abstract: Medical devices may include an electrode that has been processed to increase its surface area. In some cases, an electrode may be processed using an ultrafast laser to produce an electrode surface that includes macrostructures formed within the electrode surface and nanostructures formed on the macrostructures. The nanostructures may be formed of material that was removed from the electrode surface in forming the macrostructures.