Abstract: The antibody of the invention has high specificity to human c-Met and is cross-reactive to mouse c-Met. The antibody or its antigen-binding fragment of the invention is capable of specifically binding to human c-Met as well as mouse c-Met, more accurate preclinical results can be confirmed in the efficacy evaluation using mouse tumor models. The antibody of the invention inhibits the growth of cancer cells derived from various cancers by a considerable binding affinity to c-Met and the suppression of c-Met function therefrom, inhibits the phosphorylation of c-Met and downstream signaling molecules to suppress c-Met signaling, and inhibits neovascularization, thereby being very efficient in the prevention and treatment of cancers.

Abstract: Disclosed herein are methods to inhibit cleavage of a type I receptor of transforming growth factor beta (T?RI) and reduce cancer cell invasiveness/metastasis, and agents and pharmaceutical compositions for use in these methods. Also disclosed herein are methods for identifying agents that inhibit cleavage of T?RI and methods for diagnosing and/or prognosing cancer based on nuclear localization of a intracellular domain of T?RI, which is a product of T?RI cleavage.

Abstract: Human prion protein, PrP, selectively presents the epitope MDEYSNQNN (SEQ ID No. 14) when PrP misfolds. The misfolded form of human PrP is associated with various disease states. The present invention provides an antibody useful to detect and treat such diseases, including cancer such as ovarian cancer and lymphomas, and transmissible spongiform encephalopathies such as CJD. Also provided is an immunoconjugate in which the antibody is conjugated with urease as cytotoxin.

Abstract: The present invention relates to nucleic acids encoding anti-CD20 antigen binding molecules (ABMs). In particular embodiments, the present invention relates to nucleic acid encoding recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human CD20. In some embodiments, the invention relates to an isolated polynucleotide comprising a) a sequence encoding a polypeptide having a sequence selected from the group consisting of SEQ ID NO:40; SEQ ID NO:32; SEQ ID NO:56; and SEQ ID NO:60; and b) a sequence encoding a polypeptide having the sequence of SEQ ID NO:76. In addition, the present invention relates to vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.

Abstract: New combined therapeutic regimens for treatment of B-cell lymphomas are disclosed which comprise, in particular, administration of anti-CD20 antibodies to patients having low-, intermediate- or high-grade non-Hodgkin's lymphomas.

Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Abstract: Antibodies that bind to a GPR49 protein and have cell proliferation inhibitory activity against cells expressing the GPR49 protein are disclosed. Cell proliferation inhibitory activities are cytotoxic activities such as antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity. Pharmaceutical compositions, cell-proliferation inhibitors, and anticancer agents containing an antibody of the present invention as an active ingredient are also disclosed. Examples of cancer include gastric cancer, colon cancer, hepatocellular carcinoma, lung cancer, prostate cancer, ovarian cancer, Ewing's sarcoma, and glioma. Furthermore, methods for diagnosing cancer by detecting expression of a GPR49 protein or a gene encoding a GPR49 protein, and diagnostic agents and kits to be used in these methods are also disclosed.

Abstract: We have discovered that LRG-47 (also called p47 GTPase), plays a central role in the pathogenesis of multiple sclerosis, and that inhibition of LRG-47 activity by anti-LRG-47 antibodies or of LRG-47 expression by siRNA dramatically reduce the pathology and symptoms of multiple sclerosis. Certain embodiments of the invention are directed to the therapeutic use of anti-LRG-47 antibodies (mouse or rabbit or other antibodies that are humanized or human antibodies to LRG-47, preferably antibodies made against human LRG-47) or siRNA or antisense nucleotides that specifically hybridize with the gene or mRNA or cDNA encoding human LRG-47 to treat or prevent multiple sclerosis and other autoimmune diseases that are T-cell-mediated. Other embodiments are directed to methods for the diagnosis of multiple sclerosis or to determining the aggressiveness of multiple sclerosis by determining the amount of human LRG-47 or LRG-47 mRNA in a biological sample from the patient.

Abstract: Provided is a monoclonal antibody or a fragment thereof that selectively inhibits enzyme activity of EL and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.

Abstract: The transmembrane E3 ubiquitin ligases ZNRF3 and RNF43 are negative regulators of ?-catenin and the Wnt signaling pathway in eukaryotic cells. The activity of ZNRF3 can be modulated by antibody binding to its extracellular domain, thus causing an increase in Wnt signaling. The ZNRF3 antagonizing antibodies can be used to treat diseases with low Wnt signaling, such as short bowel syndrome, osteoporosis, diabetes, neurodegenerative diseases, and mucositis. In addition, the antagonizing antibodies of the invention can be used to enhance Wnt signaling for tissue repair and wound healing.

Abstract: The present invention provides methods of reducing or enhancing T cell activation and/or B cell activation in a subject, comprising administering to a subject an effective amount of an inhibitor or enhancer, respectively, of Semaphorin 6D (Sema6D) activity on T cells and/or B cells.

Abstract: The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.

Abstract: This invention provides a method for hydrophilic cellulose fibers capable of inhibiting decrease in the degree of polymerization and whiteness degree of oxidized cellulose fibers in oxidized cellulose in which a carbon at position 6 of each glucose unit in the cellulose fiber starting material is oxidized to a carboxyl group, the method comprising (A) the step of performing dehalogenation together with reduction, the dehalogenation comprising mixing a dehalogenation agent, a reducing agent, and oxidized cellulose fibers, and removing halogens remaining in the oxidized cellulose fibers, and the reduction comprising reducing a ketone group at position 2 and/or position 3 of each glucose unit in the oxidized cellulose fibers.

Abstract: This specification discloses an improved method for conducting the removal of C5 xylan based sugars from biomass. The improved method involves a series of soakings and washings of the biomass as opposed to conducting one soaking and washing step.

Abstract: The embodiments herein provide a method for isolation and purification of a novel oligosaccharide molecule from the fruits of Rosa arvensis for the treatment of diabetes. The fruit is dried, powdered and subjected to deionized water. The deionized water solution is subjected to silica gel column and the filtrate is subjected to ethanol-water mixture. The filtrate is subjected to column chromatography. The purified extract is structurally and chemically analyzed to find that the molecule is oligosaccharide. The purified oligosaccharide is administered to diabetic patients for 21 days. After the administration of oligosaccharide for 21 days the pancreatic tissues are collected and the blood glucose level in fasting and non fasting states is measured to find that there is significant effect in the blood glucose levels and the pancreatic tissue/cell regeneration after administration of the isolated oligosaccharide. The toxicity tests reveal that the oligosaccharide is non-toxic in nature.

Abstract: A process for producing functional polymer, the process comprising the steps of reacting an anionic initiator including a functional group with a stabilizing monomer to produce a stabilized initiator, reacting the stabilized initiator with monomer capable of being anionically polymerized to produce a polymer, and terminating the polymer.

Abstract: Disclosed herein are methods for controlling bubble formation in a polymerization reactor. The method includes: (a) determining a concentration of at least one component at a location in the reactor using a mathematical model; (b) determining a vapor pressure of the composition based at least in part upon the concentration of the component; (c) determining an operating pressure of the reactor at the location; (d) determining a pressure difference as ?P=PX?PV, wherein PX is the operating pressure and PV is the vapor pressure; (e) comparing the ?P to a threshold value; and (f) implementing an effect when the ?P is less than the threshold value.

Abstract: A process for preparing polyolefin in a polymerization loop reactor can include feeding olefin monomer, liquid diluent, polymerization catalyst, optionally hydrogen, and optionally olefin co-monomer into the polymerization loop reactor. The process can include polymerizing the olefin monomer and optionally the olefin co-monomer to produce a polyolefin slurry in the polymerization loop reactor. The polymerization loop reactor can include a plurality of interconnected pipes defining a flow path for the polyolefin slurry. The polymerization loop reactor can include one or more settling legs provided on at least one horizontal part of the interconnected pipes. The circulation velocity of the polyolefin slurry inside at least one horizontal part of the interconnected pipes provided with one or more settling legs can be reduced by at least 20% and at most 60% compared to a circulation velocity inside a remainder of the polymerization loop reactor.

Abstract: The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety, a hydrolytic stable linker and two polymerizable functional groups are incorporated into the photoinitiator structure.

Abstract: Provided is a non-cyclopentadienyl-based chromium-ligand complex, preferably a chromium-ligand complex of formula (J): LCr(RA)m(D)k (J), wherein L is a non-Cp monoanionic ligand; Cr (chromium) is in a formal oxidation state of +3 or +2; when Cr formally is Cr+3, either m is 1 and RA is hydrocarbylene (a hydrocarbylene chromium-ligand complex of formula (J)) or m is 2 and each RA independently is hydrocarbyl (a dihydrocarbyl chromium-ligand complex of formula (J)), wherein each hydrocarbyl or hydrocarbylene of RA independently is unsubstituted or substituted by from 1 to 5 RAS; each RAS independently is a neutral aprotic heteroalkyl, neutral aprotic heterocycloalkyl, neutral aprotic heteroaryl, or neutral aprotic aryl; when Cr formally is Cr+2, m is 1 and RA is hydrocarbyl (a hydrocarbyl chromium-ligand complex of formula (J)); k is an integer of 0 or 1; D is absent when k is 0 or D is a neutral ligand when k is 1; wherein the chromium-ligand complex of formula (J) is overall neutral and lacks a cyclopentadien

Abstract: Methods and systems for pelletizing low molecular weight semi-crystalline polymers are provided herein. Polymer compositions comprising the semi-crystalline polymer and a solvent are provided to a devolatilizing device, where the solvent is at least partially evaporated under vacuum conditions, resulting in removal of heat from the polymer by evaporative cooling and crystallization of the polymer. Once the polymer has reached the desired temperature, the polymer exits the devolatilizer and is pelletized. Semi-crystalline polymers that may be used in the present invention include propylene-based copolymers, such as propylene-ethylene and propylene-hexene copolymers having a heat of fusion, Hf, from about 5 to about 75 J/g and a weight average molecular weight, Mw, from about 10,000 to about 200,000 g/mol.

Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).

Abstract: Provided herein is a multifunctional particle and methods of forming the same. The multifunctional particle includes: a silica particle; a hydrophobic silane; and a silane coupling agent; where each of the hydrophobic silane and the silane coupling agent are chemically bonded to the surface of the silica particle; where the multifunctional particle is superhydrophobic and chemically reactive.

Abstract: The present invention provides a functional diene polymer, a preparation method thereof and a rubber composition comprising the functional diene polymer. The functional diene polymer comprises at least one type of conjugated diene structural units and silane coupler functional units represented by formula (I) in its molecular chain, and the number-average molecular weight of the functional diene polymer is 50,000˜1,000,000; R1-R4 are C1-C20 linear or branched alkyl or heteroatom-containing C1-C20 linear or branched alkyl, and the heteroatom is selected from one or more of halogen, oxygen, sulfur, silicon, and phosphorus. Not only the relationship between the wet slip resistance and the rolling resistance of the functional diene polymer is effectively improved, but also the offensive odor produced in the rubber mixing process owing to the addition of the silane coupler is reduced.

Abstract: A process for preparing isobutene homo- or copolymer derivatives by (i) polymerizing isobutene or an isobutene-comprising monomer mixture in the presence of an iron halide-donor complex, an aluminum trihalide-donor complex, or an alkylaluminum halide-donor complex, (ii) reacting a resulting high-reactivity isobutene polymer with a compound which introduces a low molecular weight polar group or a substructure thereof, and (iii) in the case of reaction with a substructure, further reacting to complete the formation of the low molecular weight polar group. The homo- or copolymer derivatives include a radical of a hydrophobic polyisobutene polymer having a number-average molecular weight of 110 to 250,000 and low molecular weight polar groups including amino functions, nitro groups, hydroxyl groups, mercaptan groups, carboxylic acid or carboxylic acid derivative functions, sulfonic acid or sulfonic acid derivative functions, aldehyde functions and/or silyl groups.

Abstract: A copolymer obtained by polymerizing two or more types of monomers, wherein among fractions obtained by dividing an eluate showing peaks relative to the copolymer, in an elution curve obtained by gel permeation chromatography (GPC), into eight fractions in order of fractionation, such that each fraction has the same volume, a difference between a monomer composition ratio of a copolymer contained in a first eluted fraction and a monomer composition ratio of all copolymers is ?3 mol % to +3 mol % in any of the constitutional units derived from the respective monomers.

Abstract: The present invention provides a simple, non-destructive and versatile method that enables layer-by-layer (LbL) assembly to be performed on virtually any substrate. A novel catechol-functionalized polymer which adsorbs to virtually all surfaces and can serve as a platform for LbL assembly in a surface-independent fashion is also provided.

Abstract: The present invention relates to a molded article comprising a polypropylene composition, wherein the polypropylene composition comprises comonomer units derived from ethylene in an amount of from 0.5 wt % to 35 wt %, and from at least one C5-12 alpha-olefin in an amount of from 1.0 mol % to 3.0 mol %, wherein the polypropylene composition has an amount of xylene solubles XS of from 20 wt % to 39 wt %, and the xylene solubles have an amount of ethylene-derived comonomer units of from 4.0 wt % to 70 wt %.

Abstract: Provided is an olefin resin composition, and a method of manufacturing an encapsulant for an optoelectronic device, in which the encapsulant exhibits excellent adhesive strength with a back sheet and a front substrate included in various optoelectronic devices. In addition, the encapsulant does not have a bad influence on parts such as optoelectronic units or wiring electrodes encapsulated in an optoelectronic device, and a working environment, and can excellently maintain workability and economic feasibility of device manufacturing.

Abstract: The present invention relates to a tooth-whitening composition comprising (i) a substantially water-insoluble and substantially non-degradable polymer matrix component capable of adhering to the surface of a tooth, provided that if the polymer matrix component is in non-solid form, it is solidifiable by chemical alteration; and (ii) gas- or liquid-filled pores embedded in said polymer matrix component, wherein at least a portion of said gas- or liquid-filled pores have at least one size dimension in the range of about 70 nm to about 5 microns, and wherein the gas- or liquid-filled pores and polymer matrix component possess a difference in refractive index of at least 0.1. The invention is also directed to a tooth-whitening system containing the above composition in combination with an applicator device. The invention is also directed to methods for applying the tooth-whitening composition onto teeth.

Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.

Abstract: According to one embodiment, a polymer material includes two or more different repeating units each containing a quinoxaline backbone. At least one of the repeating units includes a halogen atom.

Abstract: An object of the present invention is to provide a polychloroprene latex with improved rubber coagulability that gives a film superior in strength by dip molding, a polychloroprene latex composition, and a molded article. The polychloroprene latex is prepared by polymerization of 2-chloro-1,3-butadiene alone or by polymerization of raw monomers at least containing 2 -chloro-1,3-butadiene and 2,3-dichloro 1,3-butadiene and has a precipitation rate of 5 to 40%, as calculated according to Equation (I). In Equation (I), A is the mass (g) of the dry product, which is obtained by adding 50 ml of saturated aqueous solution of calcium hydroxide at 23° C. to 50 g of a latex having a solid matter concentration adjusted to 45 to 65 mass % at a liquid temperature of 23° C. over 2 minutes, filtering and collecting the generated precipitate with a 80 -mesh wire mesh, and drying the precipitate at 110° C.

Abstract: It has been found that certain cells in culture can convert more than about 0.002 percent of the carbon available in the cell culture medium into isoprene. These cells have a heterologous nucleic acid that (i) encodes an isoprene synthase polypeptide and (ii) is operably linked to a promoter. The isoprene produced in such a cultured medium can then be recovered and polymerized into synthetic rubbers and other useful polymeric materials. The synthetic isoprene containing polymers of this invention offer the benefit of being verifiable as to being derived from non-petrochemical based resources. They can also be analytically distinguished from rubbers that come from natural sources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has ?13C value of greater than ?22%.

Abstract: The invention relates to a process for the preparation of polymers and to an apparatus for performing this process. The apparatus comprises devices and reactors that are combined in the sequence of first a mixing device, second a flow microwave and optionally third one or more additional reactors.

Abstract: A resin composition having as a main ingredient a block copolymer composed of at least one type of vinyl aromatic hydrocarbon and a conjugated diene, the resin composition being characterized in that the Vicat softening point temperature measured under a 10-N load as per ISO306 is 65-90° C., the flexural strength measured as per ISO178 is 58-80 MPa, the proportion of the conjugated diene in the resin composition is 10-25 mass %, and the resin composition has molecular weight peaks, the peaks being derived from the block copolymer composed of the vinyl aromatic hydrocarbon and the conjugated diene, at molecular weights in the ranges of 70,000-150,000 and 150,000-350,000, respectively.

Abstract: The present invention relates to a method for producing a hydrogenated block copolymer, including the steps of: (a) forming a block copolymer by allowing a living polymer having a specific structure to react with a tetra- or more functional silane coupling agent; (b) hydrogenating the block copolymer to form a hydrogenated block copolymer; (c) isolating the resultant hydrogenated block copolymer; and (d) deactivating a functional group in the silane coupling agent and/or an unreacted functional group present in a coupling agent residue in the block copolymer or the hydrogenated block copolymer prior to the step (c), in which the number of functional groups derived from the coupling agent in the hydrogenated block copolymer recovered in the step (c) is 1.5 or less per block copolymer molecule; a hydrogenated block copolymer obtained by the method; and a composition containing the hydrogenated block copolymer.

Abstract: Transparent and impact-resistant crosslinked acrylic composition consisting of a brittle matrix (I) having a glass transition temperature of greater than 0° C. and of elastomeric domains having a characteristic dimension of less than 100 nm consisting of macromolecular sequences (II) having a flexible nature with a glass transition temperature of less than 0° C.

Abstract: The present invention relates to novel high-latency liquid hardeners for hardening of curable polymer resins, especially epoxy resins, and to epoxy resin compositions comprising liquid hardeners for the production of fiber composite materials.

Abstract: The present invention relates to predominantly open-cell, cold-deformable, rigid polyurethane foams which possess a uniform cell structure with similar cell sizes and similar physical properties, more particularly a similar open-cell content. These foams are suitable for producing automotive interior trim, more particularly roof linings and pillar trim.

Abstract: A curable resin comprising a compound having the structure wherein each carbon 2, together with either its carbon 1 or carbon 3, are members of a fused cycloaliphatic ring, and when carbon 1 is a member of the ring so is N, and wherein each of the aliphatic or aromatic ring-member carbons may either be members of further fused cycloaliphatic rings or be bonded to a group selected from H or linear or branched C1 to C5 alkyl.

Abstract: The present invention relates to a polymer and the associated polymerization process, and to the use of the polymers according to the invention for example as foam suppressant, for the dispersion of solids or as surfactant for washing or cleaning purposes. The polymer is prepared by polymerization of a) at least one alkylene oxide or a cyclic carbonate of the formula (I) where n is 1 to 10, m is 0 to 3 and R1 is C1-C10-alkyl, C2-C10-alkenyl, aryl or aralkyl, b) glycerol carbonate and c) at least one amine.

Abstract: The present invention relates to a method for producing polyetherester carbonate polyols by means of catalytic addition of carbon dioxide, alkylene oxides and cyclic anhydrides to H-functional starter compounds in the presence of double metal cyanide (DMC) catalysts.

Abstract: There is described a process for producing a gel free hyperbranched polyamide polymer having primary amino groups (useful as a crosslinker). The process comprises the step of reacting at least one diamine and at least one unsaturated diester in a molar ratio of diamine to diester greater than 1 but less than 3 (preferably 2.1 to 2.9); to form the polyamide in a two stage reaction Michael addition and then amidation. The diamine in kept in excess with at least 5% of water by total weight of the diamine and diester, a reaction temperature less than the boiling point of the diamine; and is held under reduced pressure (30 mbar to 1 atms). Gelation does not occur even after substantially all ethylenic (—C?C—) double bonds; and >95% ester [—C(O)?O] groups have reacted. This violates the Flory rules which predict a gel would form based on the number of functional groups present and their degree of conversion.

Abstract: Methods of preparing a polyaniline homopolymer or copolymer comprising at least one carboxylic acid group, and homopolymers or copolymers arising therefrom, the methods comprising: preparing a solution of a polyaniline precursor having at least one aromatic amine group and at least one carboxylic acid group (eg. 2-aminobenzoic acid, 3-aminobenzoic acid or 4-aminobenzoic acid) in a solvent selected from aqueous methanesulfonic acid or aqueous ammonia and optionally one or more additional polyaniline precursors (such as aniline); and oxidatively polymerising the polyaniline precursor or precursors.

Abstract: A polyoctatriazacane molecule is disclosed that has a plurality of octatriazacane groups having the structure and a plurality of divalent bridging groups, each divalent bridging group comprising an aromatic group.

Abstract: A polyoctatriazacane molecule is disclosed that has a plurality of octatriazacane groups having the structure and a plurality of divalent bridging groups, each divalent bridging group comprising an aromatic group.

Abstract: The present invention relates to a novel polymeric material for a highly efficient organic thin-film solar cell with high hole mobility and power conversion efficiency. In the polymeric material, a compound containing an electron donating group represented by Formula 1 or 2 and a compound containing an electron accepting group represented by one of Formulae 3 to 8 are repeatedly introduced in an alternating manner.

Abstract: A crosslinkable polysiloxane molecule is in the form of a polysiloxane polymeric chain with a pendant group, that is, a benzoxazine group, and thus is capable of undergoing a cross-linking reaction spontaneously to produce a crosslinkable polysiloxane polymeric material. The benzoxazine group enhances the compatibility between a polysiloxane polymer and a conventional organic polymeric material, functions as a polymer flame retardant or reaction-oriented additive, and widens the application of a polysiloxane polymer to organic polymeric materials in property adjustment and the applicability of the organic polymeric materials.

Abstract: This invention relates to high hydrocarbon resistant chemically cross-linked aromatic polyimide polymers, membranes and methods for making and using these polymers and membranes. The high hydrocarbon resistant chemically cross-linked aromatic polyimide membrane described in the present invention comprises a plurality of repeating units of a first aromatic polyimide comprising hydroxyl groups cross-linked with a second aromatic polyimide comprising carboxylic acid groups via covalent ester bonds. These membranes exhibit high permeability and selectivity in separation of mixtures of gases and liquids.