Abstract: The invention provides compositions and methods for controlling setting of carbonatable calcium silicate compositions that are contaminated with hydrating materials. These carbonatable calcium silicate cements are suitable for use as non-hydraulic cement that hardens by a carbonation process and may be applied in a variety of concrete components in the infrastructure, construction, pavement and landscaping industries.
Abstract: An expanded lightweight aggregate has compositional ranges (Wt. % Range) of about: (a) 40 to 60% ground glass or pumice, 40 to 60% water, 3 to 15% sodium silicate, and 0.1 to 5% NaNO3 for the slurry; and (b) 50 to 85% ground glass or pumice, and 15 to 50% slurry for the granulator.
Abstract: A heat-resistant member 10 includes a member 12 that is a target to be protected and a protective layer 14 arranged on the whole or part of a surface of the member 12. The protective layer 14 includes an oxide ceramic containing an Fe3O4 phase in which a solute component capable of forming a spinel-type oxide with Fe is solid-dissolved.
Abstract: A window material for an ultraviolet light emitting device for emitting an ultraviolet light having a wavelength of 300 nm or less is mounted on at least an ultraviolet light emitting side of the ultraviolet light emitting device. The window material for an ultraviolet light emitting device contains a translucent alumina substrate, and a surface of the window material has an average grain diameter of 6 to 60 ?m.
Abstract: A honeycomb structural body 40 includes: a partition wall 48 formed of a porous ceramic which forms and defines a plurality of cells 47 each functioning as a flow path of a fluid and extending from one end surface to the other end surface; and an outer circumference wall 49 formed along the outermost circumference, where an oxide ceramic containing a Fe3O4 phase in which a solute component capable of forming a spinel-type oxide with Fe is solid-dissolved is formed.
Abstract: A method of making a fiber tow coating is provided. The method includes providing a fiber tow selected from the group consisting of carbon and silicon; and applying an oxide-based fiber interface coating onto the fiber tow using directed vapor deposition or other like deposition method.
Type:
Application
Filed:
October 6, 2015
Publication date:
April 7, 2016
Inventors:
Adam L. Chamberlain, Andrew J. Lazur, Kang N. Lee
Abstract: Processes capable of producing bulk materials suitable for use by the horticulture industry, resulting bulk materials produced thereby, and applications for these processes and materials. Preferred bulk materials have physical properties similar to peat moss and comprise individual materials, each at least partially having a twisted, curled, clumped and rolled structure. The individual materials may further comprise small granular particles dispersed throughout the twisted, curled, clumped and rolled structure. The individual materials may be rolled fibers such that the bulk material has physical properties similar to sphagnum peat moss so as to be particularly suitable as, for example, a soil conditioner, an absorbent material, a chemical carrier, or a filtering material. Alternatively, the individual materials may be rolled particles such that the bulk material has physical properties similar to milled peat moss so as to be particularly suitable as propagation media.
Type:
Application
Filed:
September 17, 2015
Publication date:
April 7, 2016
Inventors:
Mont Andrew Handley, Matt Collins Knapp, Mark David Goldman
Abstract: A solid combustible propellant composition is disclosed comprising a solid oxidizer composition comprising ammonium nitrate and at least one other solid oxidizer having a decomposition or melting temperature of at least 500° C., a fuel, and a polymer binder that decomposes by chain scission to undergo liquefaction during combustion of the propellant composition.
Abstract: Methods for forming bio-derived fuel products, upgrading bio-derived feedstocks, and processing bio-derived normal nonane are provided. In an embodiment, a method for forming a bio-derived fuel product includes providing a bio-derived hydrocarbon stream comprising at least about 50 wt % normal nonane and having a research octane number of less than about 10. The method further includes isomerizing the bio-derived hydrocarbon stream over a non-zeolitic, non-sulfated and/or non-halogenated catalyst to form the bio-derived fuel product with a research octane number of greater than about 50.
Abstract: A fractionation system for a polymerization reactor includes a membrane separation system designed to separate light components, such as unreacted monomer and inerts, from diluent. The membrane separation system may employ one or more membrane modules designed to separate hydrocarbons based on size, solubility, or combinations thereof. The fractionation system also may include a heavies fractionation column designed to separate heavy components, such as unreacted comonomer and oligomers, from the diluent.
Type:
Application
Filed:
December 14, 2015
Publication date:
April 7, 2016
Inventors:
Andrew J. Mills, Andrea L. Hoener, Ralph W. Romig
Abstract: Disclosed are systems and methods which provide a process stream comprising a gaseous component, capture the gaseous component from the process stream by an ionic liquid solvent of a separator, and recover a captured gaseous component from the ionic liquid solvent in a regenerator. A second gaseous component from the process stream may be captured by the ionic liquid solvent of the separator, and the second gaseous component may be recovered from the ionic liquid solvent in the regenerator. Alternatively, the second gaseous component from the process stream may be uncaptured by the ionic liquid solvent, and the uncaptured second gaseous component may be recovered from a membrane unit.
Type:
Application
Filed:
December 11, 2015
Publication date:
April 7, 2016
Inventors:
Lei JI, Ai-Fu CHANG, Michael S. DRIVER, Hye-Kyung TIMKEN
Abstract: In the halogenation reaction of olefin/halo-olefin (i.e., organic), an excess amount of halogen gas (fluorine, chlorine, vaporized bromine and iodine, or their combination) is normally used in order to achieve as complete as possible conversion of the organic. In a conventional process, the excess halogen gas in the off-gas stream is scrubbed by caustic solution which increases the consumption of halogen and generates waste for disposal. The present invention provides a novel process to recover and reuse the excess halogen gas and thus reduce the operating cost of the process.
Abstract: A method for preparing 2,3,3,3-tetrafluoropropene, including: a) heating and vaporizing hydrogen fluoride and 1,1,2,3-tetrachloropropene (TCP), and introducing hydrogen fluoride and TCP to a first reactor for reaction in the presence of an A-type catalyst to yield a first product mixture including 2,3-dichloro-3,3-difluoropropene (“HCFO-1232xf”), where the mole ratio between hydrogen fluoride and TCP is between 5:1 and 60:1, the reaction temperature is between 200 and 500° C., and the space velocity is between 200 and 2000 h?1; b) preheating the first product mixture including HCFO-1232xf, introducing the first product mixture including HCFO-1232xf to a second reactor for reaction in the presence of a B-type catalyst to yield a second product mixture including HFO-1234yf, where the temperature of the preheated first product mixture including HCFO-1232xf is higher than the reaction temperature of the first reactor and lower than the reaction temperature of the second reactor.
Type:
Application
Filed:
December 11, 2015
Publication date:
April 7, 2016
Inventors:
Jun LEI, Bo YANG, Yan ZHANG, Yang ZHAO, Huadong ZHOU, Qiang ZHOU, Gang SU
Abstract: The invention provides a process for the preparation of monoethylene glycol from sucrose comprising the steps of: i) hydrolysing sucrose to form a reaction product stream comprising glucose and fructose; ii) separating the reaction product stream comprising glucose and fructose into a fructose or fructose derivative rich stream and a glucose rich stream; and iii) contacting the glucose rich stream with hydrogen in a reactor in the presence of a solvent and a catalyst system with catalytic hydrogenation abilities to produce a product stream comprising monoethylene glycol.
Type:
Application
Filed:
April 23, 2014
Publication date:
April 7, 2016
Inventors:
Jean Paul Andre Marie Joseph Gishlain LANGE, Pieter HUIZENGA
Abstract: The invention provides a process for the recovery of 1,4-butanediol from an aqueous stream, said process comprising the steps of providing the aqueous stream, providing a first solvent stream, combining said aqueous stream with said first solvent stream and recovering at least a portion of the 1,4-butanediol by liquid-liquid extraction.
Type:
Application
Filed:
May 28, 2014
Publication date:
April 7, 2016
Applicant:
SHELL OIL COMPANY
Inventors:
Wouter KOOT, Sipke Hidde WADMAN, Jean Paul Andre Marie Joseph Gishlain LANGE, Kai Jürgen FISCHER
Abstract: A method of making an anti-Markovnikov addition product, comprises reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said anti-Markovnikov addition product; the dual catalyst reaction system comprising a single electron oxidation catalyst in combination with a hydrogen atom donor catalyst. Dual catalyst composition useful for carrying out such methods are also described.
Abstract: Provided is a method for preparing a diaryl ether compound through the dehydration of an aromatic alcohol compound in the presence of a halogenated rare earth element oxide catalyst, wherein the used dehydration catalyst may be regenerated by a halogenation step. The rare earth element oxide is an oxide of a light rare earth element, an oxide of a medium rare earth element, an oxide of a heavy rare earth element, an oxide of yttrium, or a mixtures of two or more thereof.
Type:
Application
Filed:
June 9, 2014
Publication date:
April 7, 2016
Inventors:
Paul R. Elowe, David G. Barton, Adam Chojecki, Beata A. Kilos, Dennis W. Jewell, Adam S. Cieszlak, Bruce D. Hook
Abstract: A system and process for the recovery of at least one halogenated hydrocarbon from a gas stream. The recovery includes adsorption by exposing the gas stream to an adsorbent with a lattice structure having pore diameters with an average pore opening of between about 5 and about 50 angstroms. The adsorbent is then regenerated by exposing the adsorbent to a purge gas under conditions which efficiently desorb the at least one adsorbed halogenated hydrocarbon from the adsorbent. The at least one halogenated hydrocarbon (and impurities or reaction products) can be condensed from the purge gas and subjected to fractional distillation to provide a recovered halogenated hydrocarbon.
Type:
Application
Filed:
December 11, 2015
Publication date:
April 7, 2016
Inventors:
Dusanka FILIPOVIC, Laurence WHITBY, Biljna MILIN, Frederick CASHIN
Abstract: A catalyst composition is useful for producing a ketone from a compound containing at least one epoxide group, and the catalyst composition contains at least one precious metal; and at least one mixed oxide; wherein the mixed oxide contains zirconium dioxide and silicon dioxide; wherein the precious metal is supported and the support is not entirely made of the mixed oxide; and wherein a mass ratio of zirconium dioxide to silicon dioxide in the mixed oxide is 86:14 to 99.9:0.1.
Abstract: Compounds of structure (I): including stereoisomers, tautomers and salts thereof, wherein R1, R2, R3, R4, R5, R6, X, Y and Z are as defined herein. Such compounds are useful for the preparation of diarylpropane compounds. Methods for the preparation of compounds of structure (I) are also disclosed, as are methods employing compounds of structure (I) for the preparation of diarylpropanes.
Type:
Application
Filed:
April 29, 2015
Publication date:
April 7, 2016
Inventors:
Sandip K. Nandy, Abeysinghe Arrachchigae Padmapriya
Abstract: The method disclosed herein relates to two stage catalytic processes for converting syngas to acetic acid, acrylic acid and/or propylene. More specifically, the method described and claimed herein relate to a method of producing acrylic acid and acetic acid comprising the steps of: a) providing a feedstream comprising syngas; b) contacting the feedstream with a first catalyst to produce a first product stream comprising C2-C3 olefins and/or C2-C3 paraffins; and c) contacting the first product stream with oxygen gas and a second catalyst, thereby producing a second product stream comprising acrylic acid and acetic acid, wherein there is no step for separating the components of the first product stream before the first product stream is contacted with the second catalyst.
Abstract: Provided is a method of separating lactic acid or a salt thereof. The method includes removing a coloring material, including hydroxymethylfurfural (HMF), from a fermentation broth, which includes at least one of lactic acid and a salt thereof; and recovering lactic acid or a salt thereof from the fermentation broth, from which the coloring material has been removed.
Type:
Application
Filed:
October 7, 2015
Publication date:
April 7, 2016
Inventors:
Jaeeun Kim, Donwook Lee, Jinkyu Kang, Eunsuk Kwon, Hyerim Gwon, Kwangmyung Cho
Abstract: Disclosed is a method of reducing the ultraviolet-light absorbing properties of a composition comprising dioctyl phthalate, the method comprising (a) obtaining a composition comprising dioctyl phthalate and phthalide, wherein said composition has an absorbance of greater than 0.1 at a wavelength of about from 230 to 360 nm, (b) contacting the composition with activated carbon, silica gel, or diatomaceous earth, for a sufficient amount of time to allow the phthalide to contact the activated carbon, silica gel, or diatomaceous earth, and (c) removing the composition from the activated carbon, silica gel, or diatomaceous earth, wherein the composition obtained from step (c) has an absorbance equal to or less than about 0.1 at a wavelength of about from 230 to 360 nm and has a reduced amount of phthalide when compared with the composition from step (a).
Type:
Application
Filed:
June 4, 2014
Publication date:
April 7, 2016
Inventors:
Mubarik Ali BASHIR, Mohammad RAFI, Emmanuel OSEI-TWUN
Abstract: The invention relates to (among other things) oligomer-amino acid conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated amino acid compounds.
Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
Type:
Application
Filed:
September 9, 2015
Publication date:
April 7, 2016
Inventors:
Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
Abstract: A modular system and method for producing urea from stranded natural gas includes removal of foreign particulate matter to obtain a substantially homogeneous gas. The gas is processed by controlling the quality of the stranded natural gas to maintain a substantially homogenous mixture The resultant gas stream is further cleaned and compressed to a high pressure of about 3,000 psi. The resultant ammonia stream is processed in a bypass recycling loop system at 30% conversion rate at a high pressure of about 6,000 to 7,000 psi. The equipment associated with each of the process steps may be skid mounted for portability and/or contained within the footprint of a standard 48-foot flatbed trailer.
Type:
Application
Filed:
July 17, 2015
Publication date:
April 7, 2016
Inventors:
James L. Simonton, Terry R. Collins, Mario G. Beruvides, Jessie Lozada, JR.
Abstract: A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino group, primary aromatic amino group, or secondary aromatic amino group, and (2) a guanylating agent; (b) allowing or inducing reaction of the amine compound and the guanylating agent to form a guanylated amine compound; (c) combining (1) the guanylated amine compound, and (2) a reactive monomer comprising (i) at least one ethylenically unsaturated group and (ii) at least one group that is reactive with an amino group; and (d) allowing or inducing reaction of the guanylated amine compound and the reactive monomer to form a guanidino-functional, free radically polymerizable compound.
Type:
Application
Filed:
June 12, 2014
Publication date:
April 7, 2016
Inventors:
Jerald K. Rasmussen, George W. Griesgraber, James I. Hembre
Abstract: The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R1 represents a methyl group or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.
Abstract: The present invention is a compound of the formula or a pharmaceutically acceptable salt thereof. The compounds are useful as HDAC inhibitors.
Type:
Application
Filed:
May 12, 2014
Publication date:
April 7, 2016
Inventors:
Stephen J. Shuttleworth, Cyrille D. Tomassi, Alexander R. Cecil, Somhairle MacCormick, William J. Nodes, Franck A. Silva
Abstract: There is provided a compound of formula I, which compound has antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and has use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
Abstract: The present disclosure relates to co-crystals comprising N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and a co-former and methods for their preparation. The present disclosure further relates to pharmaceutical compositions comprising the co-crystal forms, as well as methods of treatment therewith and kits.
Type:
Application
Filed:
October 7, 2015
Publication date:
April 7, 2016
Applicant:
Vertex Pharmaceuticals Incorporated
Inventors:
Mark Strohmeier, John Caesar, JR., Patrick Raymond Connelly, Majed Fawaz, Eduard Luss-Lusis, Brian McClain, Ales Medek, Hai Miao, Kwame Wiredu Nti-Addae, Ping Yin, Yuegang Zhang
Abstract: A method of resolving a racemic mixture of (±)-Huperzine A to (?)-Huperzine A includes: separating the (?)-Huperzine A from the racemic mixture of (±)-Huperzine A by chiral high performance liquid chromatography (HPLC), the chiral HPLC being performed utilizing a mobile phase including a solution including an alcohol and one selected from dichloromethane, trichloromethane, and a mixture thereof, and the chiral HPLC being performed utilizing a chiral stationary phase including a polysaccharide derivative.
Type:
Application
Filed:
June 26, 2015
Publication date:
April 7, 2016
Inventors:
Yonggang Xu, Hao Wei, Song Chen, Haoning Zhang
Abstract: The present invention relates to fluorene derivatives and to electronic devices in which these compounds are used as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.
Abstract: This invention provides enantioenriched N,O-heterocyclic compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
Type:
Application
Filed:
October 7, 2015
Publication date:
April 7, 2016
Inventors:
Brian M. Stoltz, Yoshitaka Numajiri, Douglas C. Behenna
Abstract: Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine D3 receptor, 5-HT1A receptor and 5-HT2A receptor, but also can observably improve the symptoms of schizophrenia relevant to apomorphine model and MK-801 model mice, with oral absorption being good, safety being high and side-effect being less, and having developmental value as new anti-neurotic disease drugs. The present invention is the compounds having a structure of general formula (I), or geometric isomers, free alkalies, salts, hydrates or solvates thereof.
Type:
Application
Filed:
May 8, 2014
Publication date:
April 7, 2016
Applicant:
SHANAGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
Inventors:
Jianqi LI, Xiaowen CHEN, Zhilong MA, Li ZHANG, Ning CUI
Abstract: Substances and methods are disclosed for reducing or preventing metastatic behaviour in VGSC expressing cancer by the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part. Inhibition of metastatic cell behaviours such as detachability, lateral motility, transverse migration and invasiveness is demonstrated using the known drugs ranolazine and riluzole.
Abstract: Tetrahydrofuran-(THF)-2,5-dicarbaldehyde and a process of preparing the same are described. The process involves reacting THF-diols in an inert organic solvent with an oxidizing agent at a temperature up to about 50 C. The process can use either HMF or THF-diols as starting materials, and enables a single-step conversion of THF-diols into a precursor material that can be transformed into a multitude of furanic derivative compounds. THF dicarbaldehyde can be modified according to certain reaction processes to generate either new or existing derivative compounds.
Abstract: The present invention relates to a method for producing dehydro rose oxide by reacting isoprenol and prenal in the presence of at least one sulfonic acid of formula R1—SO3H as catalyst, wherein R1 is selected from phenyl which carries 2 or 3 C1-C4-alkyl substituents, phenyl which carries one C8-C20-alkyl substituent and optionally also 1 or 2 C1-C4-alkyl substituents, and naphthyl which optionally carries 1 or 2 C1-C4-alkyl substituents.
Type:
Application
Filed:
May 15, 2014
Publication date:
April 7, 2016
Inventors:
Marcus G. Schrems, Jan EGGERT, Jan U MÜLLER, Jan-Dirk ARNDT, Günter GOTTWALD, Volker HÜTT
Abstract: The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this compound or a solvate of this compound. The present invention also provides: this T-type calcium channel inhibitor; a pharmaceutical product containing this T-type calcium channel inhibitor; and a therapeutic agent or prophylactic agent for diseases, the effective action of which is a T-type calcium channel inhibitory action.
Abstract: A method of preparing an intermediate of salmeterol (Compound 1, 2-amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol) includes: reacting compound 2 with 2-methoxypropene in a first organic solvent to produce a reaction solution including compound 3, compound 2 including a 2-bromo precursor of Compound 1; reacting compound 3 with a nitrogen source to produce compound 4; reacting compound 4 with sodium borohydride in a second organic solvent to produce compound 5; and debenzylating compound 5 by ammonium formate/palladium-carbon catalytic transfer hydrogenation in a third organic solvent to produce Compound 1. A method of preparing salmeterol includes preparing Compound 1, and reacting Compound 1 to prepare salmeterol.
Type:
Application
Filed:
May 15, 2015
Publication date:
April 7, 2016
Inventors:
Yinhua Qiu, Zhengyuan Wu, Song Chen, Haoning Zhang
Abstract: Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.
Type:
Application
Filed:
September 4, 2015
Publication date:
April 7, 2016
Inventors:
Yariv Donde, Jeremiah H. Nguyen, Karen M. Kedzie, Daniel W. Gil, John E. Donello, Wha-Bin Im
Abstract: Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNF? in a mammal.
Type:
Application
Filed:
October 6, 2015
Publication date:
April 7, 2016
Inventors:
George W. MULLER, David I. STIRLING, Roger Shen-Chu CHEN
Abstract: The present invention relates to a process for preparing N-substituted 1H-pyrazole-5-carboxylic acid compounds of the formula I-A and derivatives thereof, in particular the corresponding carbonylchloride compounds (acid chlorides). It also relates to the use of these acid chlorides for preparing anthranilamide derivatives that are useful pesticides.
Type:
Application
Filed:
May 16, 2014
Publication date:
April 7, 2016
Inventors:
Christopher KORADIN, Thomas ZIERKE, Ralf HOOCK, Karsten KOERBER
Abstract: This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in ˜12% of acute myeloid leukemia (AML). The inv(16) fusion results in expression of the CBF?-SMMHC fusion protein in the blood cells of afflicted patients. The present invention provides compounds which inhibit the function of both CBF? and the CBF?-SMMHC fusion. These compounds block the growth of an inv(16) leukemia cell line as well as increase its apoptosis, while showing minimal effects against non inv(16) cell lines. As a mechanism to develop inhibitors with selectivity for the CBF?-SMMHC fusion protein, the present invention further provides dimeric derivatives of these compounds which show both increased potency as well as selectivity for CBF?-SMMHC. These compounds show potent inhibition of an inv(16) leukemia cell line with minimal effects on non inv(16) cell lines.
Type:
Application
Filed:
December 14, 2015
Publication date:
April 7, 2016
Inventors:
John H. Bushweller, Jolanta Grembecka, Anuradha Illendula, Lauren Dixon
Abstract: A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
Abstract: Biologically active cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as medicaments, pharmacological tools or biomarkers. Pharmaceutical compositions may include one or more of the nitrate ester compounds. Medicaments include one or more of the cannabinergic nitrate ester compounds and are useful in treating a variety of diseases. A method of treating, preventing or reducing the severity of a condition includes administering at least one of the disclosed nitrate ester compounds to an individual or animal in need thereof.