Abstract: The present invention relates to an electrophysiological measuring arrangement (100) and to an electrophysiological measuring method, in which a carrier (12) made of a carrier material (12?) and an aperture region (10) in the region of the carrier (12) are provided for the controlled sealing accumulation of a biological object (O). The aperture region (10) is formed with at least one aperture (14) and with a wall region (11) which, as the aperture inner wall (11i), surrounds the aperture (14), forming the latter.

Abstract: A method and system for remotely monitoring intoxication of a user, comprising: prompting the user to provide a breath sample at a time point; at a breath sample acquisition device, generating a breath sample signal upon reception of the breath sample from the user, and broadcasting a unique signature proximal in time to the time point; using a sensor of a mobile computing device, generating an authentication signal derived from detection of the unique signature; at a processing system in communication with the mobile computing device and the sample acquisition device, receiving the breath sample signal and the authentication signal; generating a verification assessment that validates provision of the breath sample by the user; determining a value of an intoxication metric for the user based upon the breath sample signal; and transforming the verification assessment and the value of the intoxication metric into an analysis of intoxication of the user.

Abstract: In certain embodiments methods of identifying T cell receptors that respond to specific target cell antigens are provided, where the methods comprise providing a substrate bearing a plurality of target cells (e.g., mammalian cells); contacting the target cells on the substrate with CD8+ T cells; and using label-free optical imaging to identify an increase in mass of a T-cell and/or a decrease in mass of a target cell, where an increase in mass of a T cell and/or a decrease in mass of a target cell is an indicator that said T cell bears a T cell receptor activated by antigens presented on said target cell.

Abstract: The present invention relates to a system for screening personalized anticancer agents, a method for screening personalized anticancer agents using the system, and an apparatus for screening personalized anticancer agents. When the inventive system for screening personalized anticancer agents is used, an anticancer agent showing an optimal anticancer activity against cancer cells collected from a patient can be selected from a variety of anticancer agents, and it is possible to previously examine a therapeutic response that can appear when the selected anticancer agent is administered into the patient. Thus, the risk of trial and error in cancer therapy can be reduced, and the cost and time required for cancer therapy can be reduced.

Abstract: The present invention relates to a mitochondrial UQCRB mutant cell line expressing the UQCRB mutant protein. The present invention is directed to a novel research method for UQCRB activity evaluation using a novel mitochondrial UQCRB mutant cell line, and provides a method for anticancer activity evaluation, a method for angiogenesis inhibitory activity evaluation, and a method for screening a UQCRB activity inhibitor. In particular, the cell line of the present invention is a novel cell line having cell proliferative and angiogenesis inducing activities, and provides a method for screening an angiogenesis inhibitor or an anticancer material through the UQCRB activity inhibitory mechanism, and thus can be applied in the development of therapeutic agents against angiogenesis or mitochondria-mediated diseases and various cancers.

Abstract: An object of the present invention is to elucidate a molecular mechanism of ligand-independent activation of EphA2 in cancer cells, make EphA2 a more useful target in the treatment of cancer, and provide a cancer testing method and the like using the mechanism. The present invention provides, for example, a cancer testing method including a step of measuring an amount of an EphA2 protein fragment having a molecular weight of from 30 kDa to 80 kDa in a sample derived from a subject.

Abstract: The method comprises the steps wherein the tumour cells from a tumor tissue sample previously taken from a particular patient are incubated ex vivo with the active agent concerned and the IC50 value thereof for these cells is determined; wherein the same patient is treated with this active agent in accordance with evidence-based therapy rules; wherein the therapy outcome is documented and classified; and wherein the documentation and/or classification of the therapy outcome obtained is assigned to the IC50 value determined ex vivo.

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Abstract: A system and method for capturing a target analyte in advance of performing spectroscopic analysis to determine the existence of the target analyte from a source contacted with a collection substrate. The collection substrate is fabricated of a material selected to have an affinity for the target analyte, sufficiently transparent in a spectral region of interest and capable of immobilizing the target analyte thereon in a manner that limits scattering sufficient to obscure spectral analysis. The collection substrate may be coated with a material selected to react with, bind to, or absorb the target analyte. The method optionally includes the step of transferring the captured target analyte to a second substrate, which may be an optical substrate. The target analyte may be captured to the collection substrate by one or more of wiping, dabbing or swabbing a target analyte carrier with the collection substrate.

Abstract: A resonator sensor module is disclosed. The resonator sensor module includes one or more sensing resonators that includes binding sites for an analyte material; one or more reference resonators that lacks any binding sites for the analyte material; a module interface; and one or more switches each including a first position that operatively couples at least one of the one or more sensing resonators and the module interface and a second position that operatively couples at least one of the one or more reference resonators and the module interface.

Abstract: A method of immobilising a target molecule on a substrate, which comprises exposing the target molecule to the substrate in the presence of a metal complex, wherein the target molecule is an unmodified target molecule, and wherein the metal complex is selected to provide a stable binding interaction between the target molecule and the substrate.

Abstract: Methods for detecting an infection with Mtb in a subject are disclosed. The methods include detecting the presence of CD8+ T cells that specifically recognize an Mtb polypeptide. The methods include in vitro assays for detecting the presence of CD8+ T cells in a biological sample, and in vivo assays that detect a delayed type hypersensitivity reaction. The methods also include detecting Mtb polypeptides and polynucleotides.

Abstract: The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits.

Abstract: In certain embodiments, the method may comprise: a) obtaining the antibody sequences from a population of B cells; b) grouping the antibody sequences to provide a plurality of groups of lineage-related antibodies; c) testing a single antibody from each of the groups in a bioassay and, after the first antibody has been identified, d) testing further antibodies that are in the same group as the first antibody in a second bioassay. In another embodiment, the method may comprise: a) testing a plurality of antibodies obtained from a first portion of an antibody producing organ of an animal; b) obtaining the sequence of a first identified antibody; c) obtaining from a second portion of said antibody producing organ the sequences of further antibodies that are related by lineage to said first antibody; and, c) testing the further antibodies in a second bioassay.

Abstract: The present invention provides methods for treating specific populations of cancer patients by immunotherapy. The methods comprise administering an immunogenic composition eliciting an immune response to measles virus to patients having measles virus-immunoreactive cancer cells.

Abstract: ADAM 12 expression and activity are up regulated in patients that have cancers of epithelial origin, such as breast cancer, colon cancer, prostate cancer, liver cancer, bladder cancer, pancreatic cancer, ovarian cancer, cervical cancer, lung cancer, and skin cancer, as well as others: Accordingly. the present invention is directed to methods for prognostic evaluation, and diagnosis of cancers of epithelial origin. In particular, the presence of ADAM 12 in a biological sample is indicative of cancer of epithelial origin. Further, the amount of ADAM 12 protein detected in biological samples, e.g. urine, correlate with disease status such that ADAM 12 levels can be used to predict the presence of, as well as the metastatic potential of cancer. Thus, measuring the level of ADAM 12 in biological samples (e.g. urine or blood) provides a quick, easy, and safe screen that can be used to both diagnose and prognose cancer in a patient.

Abstract: The present invention relates to a method for diagnosing a cancer disease, comprising (a) determining the expression of CD95L in a cancer sample, and (b) classifying the cancer disease according the level of CD95L expression.

Abstract: The present invention relates to a method for determining prognosis of cancer in a subject, which comprises the step of detecting phosphorylation of a tyrosine residue at position 2681 of TRIO in a sample obtained from the subject.

Abstract: The invention provides a device for detecting FABP in a blood sample from a patient, methods for analyzing blood on the presence of FABP, as well as methods and kits for the detection of FABP in a blood sample from a patient.

Abstract: The invention provides a method of detecting the presence of anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and detecting the binding or absence of binding of antibodies to said recombinant MHC molecules. This method allows the detection and/or identification of one or more specific MHC particularly HLA allele antibodies.

Abstract: Described herein are methods and systems for distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) and celiac disease. The methods and systems can utilize the detection of anti-vinculin antibodies and anti-CdtB antibodies to distinguish IBS from IBD and celiac disease. Further described are methods for selecting a therapy to treat IBS, IBD or celiac disease.

Abstract: The invention discloses a method for the analysis of N-glycans attached to immunoglobulin G (IgG) or IgG N-glycopeptides from human blood plasma in which relative abundance of two or more glycans is determined, out of total six, and for these glycans it is determined that they strongly correlate with age.

Abstract: The present invention provides, inter alia, methods for measuring the amount of a marker of elastic fiber injury in a sample. The methods include contacting a sample with a compound of formula (1) and carrying out mass spectrometry on the sample containing the compound of formula (1). Also provided are methods of diagnosing whether a subject has a disease characterized by elastic fiber injury, a method for improving the accuracy and precision of mass spectroscopy analysis of a marker of elastic fiber injury, and kits for determining, by mass spectrometry, the amount of a marker of elastic fiber injury in a sample from a subject. Further provided are methods for preventing the progression of the effects associated with alpha-1 antitrypsin deficiency (AATD) in a subject with normal lung function.

Abstract: The present disclosure relates to a diagnostic kit capable of accurately diagnosing diseases or disorders related with abnormal aggregation or misfolding of proteins, including disorders or diseases caused by aggregation of ?-amyloid such as Alzheimer's disease as well as disorders or diseases caused by aggregation of other proteins, based on concentration analysis of the aggregated proteins before and after dissociation.

Abstract: This invention relates to compositions and methods for diagnosing and treating concussion/mTBI.

Abstract: Compounds include carbamate derivatives of vitamin D including vitamin D3 and vitamin D2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.

Abstract: A method for testing platelet function, wherein platelet function is tested by allowing anticoagulated blood, to which a weak platelet-activating reagent has been mixed, to pass through a capillary having a platelet-adhesive surface on at least a part of its inner surface, and observing or measuring the behavior of the blood in the capillary.

Abstract: The present invention concerns methods and tools for analysing biomarkers useful for diagnosing an individual, in particular a newborn, with a respiratory disease, especially a newborn suffering from respiratory distress syndrome (RDS). The method and tools of the invention can in one embodiment be used for very rapidly detecting the ratio between lecithin and sphingomyelin in very small body fluid samples, e.g. gastric aspirate of a newborn. The invention is thus useful for obtaining a rapid treatment of RDS by administration of surfactant.

Abstract: The present invention provides blood based methods for assessing adolescent depression in a subject.

Abstract: Systems and methods for isolated sensor device protection are provided. In one embodiment, an isolated sensor device comprises: a housing having an isolation chamber; an isolator sealed within the isolation chamber; an inertial sensor assembly sealed within the isolation chamber, the inertial sensor assembly coupled to an inner surface of the isolation chamber by the isolator; and at least one progressive impact interface applied to a periphery of the inertial sensor assembly, wherein the at least one progressive impact interface extends outward from the inertial sensor assembly towards the inner surface.

Abstract: A sensor assembly comprises an electronic component portion, wherein the electronic component is a metal electrode leadless face style component and a terminal portion, wherein the terminal portion defines a through hole and the electronic component portion is received within the through hole. The electronic component portion has a press fit with the terminal portion to retain the electronic component portion to the terminal portion.

Abstract: An automotive component assembly comprises an input circuit portion for a sensor and a component portion. The input circuit portion is aligned with the component portion in a desired assembly position. A pocket is at least partially defined by the component portion to receive the input circuit portion and a clamping force retains the input circuit portion between a first layer and a second layer of the component portion forming the pocket. An overmold material is applied to retain the input circuit portion and the component portion to one another.

Abstract: A vehicle speedometer, method of communicating speed to a driver, and a set of stickers for affixing to a vehicle speedometer, wherein speed is displayed in intuitive, easily understood units which indicate to a driver of the vehicle the number of meters the vehicle travels in a very short period of time such as one second.

Abstract: A capacitive physical quantity sensor includes a first substrate a movable electrode, a fixed electrode, a second substrate, a signal applying unit a C-V conversion circuit, and an auxiliary electrode. The auxiliary electrode is disposed from a portion of the second substrate which faces the movable electrode to a portion of the second substrate which faces a displaceable region of the movable electrode. The signal applying unit applies a predetermined potential to the auxiliary electrode at the time of self-diagnosis, to thereby increase a density of electric force lines generated between the fixed electrode located in a direction of displacing the movable electrode and the movable electrode.

Abstract: An electronic device comprising: a sensor; a communication unit; and at least one processor configured to: receive a first speed measurement from the sensor; receive, via the communication unit, speed information transmitted by an external device; calculate at least one correction parameter based on the first speed measurement and the speed information; and adjust a second speed measurement that is received from the sensor based on the correction parameter.

Abstract: Described herein are embodiments of an electrical terminal test point that can be temporarily attached to an electrical terminal (e.g., terminal block) in order to provide an interface between the test leads/jumpers of a test device and the electrical contact points of the electrical terminal. In one aspect, embodiments of the electrical terminal test point provide a shield for the electrical contact points of the electrical terminal (whether or not being used for testing) from inadvertent contact and prevents test leads/jumpers of test device from accidentally falling of or being knocked off of their contact points. Electrical terminal test point can be installed and removed without affecting the electrical connections made by electrical terminal (e.g., without removing terminal screws of electrical terminal).

Abstract: A test apparatus for testing a first flash memory chip is provided. The testing apparatus includes: an interface printed circuit board (PCB), a separate PCB, and a socket device. The separate PCB is disposed over the interface PCB, and a second flash chip is placed between the interface PCB and the separate PCB. The second flash memory chip includes a first embedded flash chip and a dynamic random access memory (DRAM), and the second flash memory chip is connected to the interface PCB through corresponding first pins of the DRAM. The socket device is disposed over the separate PCB and is configured to install the first flash memory chip. The first flash memory chip is connected to the interface PCB through corresponding second pins.

Abstract: Probe head assemblies, components of probe head assemblies, test systems including the probe head assemblies and/or components thereof, and methods of operating the same. The probe head assemblies are configured to convey a plurality of test signals to and/or from a device under test and include a space transformer, a contacting assembly, and a riser that spatially separates the space transformer from the contacting assembly and conveys the plurality of test signals between the space transformer and the contacting assembly. The contacting assembly may include a frame that defines an aperture and has a coefficient of thermal expansion that is within a threshold difference of that of the device under test, a flexible dielectric body that is attached to the frame, maintained in tension by the frame, and extends across the aperture, and a plurality of conductive probes. The plurality of conductive probes may include a dual-faceted probe tip.

Abstract: A mixed-domain oscilloscope (MDO) includes a signal generator configured to generate a test signal having a span ranging from a user-configurable start frequency to a user configurable stop frequency, an output channel coupled to the signal generator and configured to transmit the test signal, an RF input channel configured to receive a return signal based on the test signal, an acquisition section configured to acquire and digitize the return signal as an acquisition record, and a ramp busy signal generator configured to substantially time-align the acquisition record with the test signal. The test signal includes a chirp signal that is a linearly swept sine wave that spans between the user-configurable start frequency and the user-configurable stop frequency. Methods include calibrating the chirp signal, connecting the MDO in various test configurations relative to external return loss bridge and DUT equipment, and performing measurements such as S21 (db), S11 (db), and distance-to-fault type measurements.

Abstract: An example circuit may include an inductor; a low-frequency sensor connected to the inductor; a high-frequency sensor connected to the inductor; and an integrator connected to the low-frequency sensor and the high frequency sensor, comprising one or more resistive devices and one or more capacitive devices, wherein the integrator is characterized by a time constant that varies as a function of the inductance of the inductor. The inductor may, for example, be part of a switched-mode power supply or an amplifier.

Abstract: According to one embodiment of a system for measuring a load impedance, comprising: a switch module, a first reference impedance, a second reference impedance, and a control module, wherein the switch module connects the first reference impedance, the second reference impedance, and the load impedance, respectively; the control module connects the switch module; the control module connects the first reference impedance via controlling the switch module to obtain a first voltage value; the control module connects the second reference impedance via controlling the switch module to obtain a second voltage value; the control module connects the load impedance via controlling the switch module to obtain a load voltage value; and the control module calculates the measured value of the load impedance according to the first voltage value, the second voltage value, and the load voltage value.

Abstract: The total current flow in a given electric circuit path is estimated by measuring the current in a second parallel current path and applying a ratio of the conductivity of the main and secondary path. Earth leakage current is measured by passing three wires through a toroid so as to detect differential current flow. Each wire is a conduction path wire parallel to each phase cable. The relative harmonic content between the fundamental and higher frequency components of a load current are calculated using a conduction path parallel to the main power cables.

Abstract: A peak detector circuit receives an oscillating power supply signal. A capacitor is selectably coupled to the signal and charged to a value corresponding to a peak value of the signal. A switch is then opened to isolate the capacitor. When the signal rises to within a selected threshold, relative to the stored value, a comparator produces a command signal to close the switch, again coupling the capacitor to the signal. The peak detector can also include a tracking circuit that controls the capacitor to track the oscillating signal while the switch is closed, a timer circuit that closes the switch and activates the tracking circuit if more than a selected time passes without production of a command signal, a circuit that controls the polarity of a leakage current of the capacitor, a further auxiliary capacitor and a further auxiliary switch with a further control logic.

Abstract: A semiconductor device operates with electric power supplied from a direct-current power supply to an internal circuit in a state where a bypass capacitor is connected to a power supply terminal. The semiconductor device includes a load current control unit and a detection unit. The load current control unit changes an electric current supplied from the power supply terminal only in a predetermined operation period. The detection unit detects a voltage of the power supply terminal. The detection unit outputs a detection signal when the voltage is higher than a threshold upper limit in a case of being provided with the threshold upper limit. Alternatively, the detection unit outputs a detection signal when the voltage is lower than a threshold lower limit in a case of being provided with the threshold lower limit.

Abstract: Software that uses actual, historic building management system (BMS) data and/or machine logic to estimate an amount of energy that would have been consumed (and saved) had the BMS been operated under the control of an energy management system (EMS). The software performs the following steps: (i) receiving first actual BMS information relating to operation of a first set of appliance(s) located in a first building during a first time interval; (ii) selecting a first proposed EMS rule set; and (iii) determining a first contrafactual energy resource use value based, at least in part, on the first actual BMS information, with the first contrafactual use value corresponding to an amount of energy resources that would have been consumed by the first set of appliance(s) if the BMS had operated the first set of appliance(s) under control of the first proposed EMS rule set.

Abstract: A circuit apparatus measures, records, transmits, and displays actual and estimated power consumption in a branch circuit of an electrical distribution system. The apparatus includes a display driver coupled to one or more current sensors which derives or estimates power consumption from measured current. The accuracy of power consumption is improved by additional measurement of actual supplied voltage. A plurality of current sensors determine differential current to provide ground fault interruption to a desired range of precision. A store enables display of surge and average current measurements and power measurements in addition to immediate results.

Abstract: A vehicle electrical power flow monitoring system including at least one channel power monitor node corresponding to a respective power distribution channel of a vehicle electrical power system, the at least one channel power monitor node being common to at least another different vehicle monitoring system, and at least one data acquisition node within each power distribution channel, each of the at least one data acquisition node being common to the at least another different vehicle monitoring system and communicably connected to a respective channel power monitor node, and wherein the at least one channel power monitor node is configured to receive electrical power flow data from a corresponding data acquisition node and determine an operating state of the vehicle electrical power system based on the electrical power flow data.

Abstract: A method for storing information within a utility meter that includes storing a data stream comprising a plurality of data values regarding a metered quantity delivered to a load corresponding to a plurality of time periods, wherein the plurality of data values are stored sequentially based on their corresponding time periods. The method also includes responsive to a power outage, inserting into the data stream a time stamp corresponding to a time period in the plurality of time periods in which the power outage occurred.

Abstract: Identification of a power source in a multiple power source scenario and characterization of loads. Embodiments herein relate to loads being supplied by multiple power sources and more particularly to identifying the power source supplying power to the load. Embodiments herein disclose a method and system for determining a power source providing power to a load, wherein the load is connected to a plurality of power sources. Disclosed herein is a method and system for characterizing at least one load currently connected to at least one power supply.

Abstract: Some embodiments include an apparatus for determining statistical mean and maximum expected of electromagnetic energy transmission between coupled cavities. Other embodiments of related apparatuses and methods are also disclosed.