Patents Issued in April 26, 2016
  • Patent number: 9321681
    Abstract: A method for making geopolymer cementitious binder compositions for cementitious products such as concrete, precast construction elements and panels, mortar and repair materials, and the like is disclosed. The geopolymer cementitious compositions of some embodiments are made by mixing a synergistic mixture of thermally activated aluminosilicate mineral, calcium aluminate cement, a calcium sulfate and a chemical activator with water.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: April 26, 2016
    Assignee: UNITED STATES GYPSUM COMPANY
    Inventor: Ashish Dubey
  • Patent number: 9321682
    Abstract: The present invention relates to building materials, in particular a method for the production of a binder for concrete, mortar or plaster, and a binder produced according to this method as well the use thereof.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: April 26, 2016
    Assignee: HEIDELBERGCEMENT AG
    Inventors: Mohsen Ben Haha, Tim Link, Frank Bellmann, Horst-Michael Ludwig
  • Patent number: 9321683
    Abstract: A process for decarbonation of particles of raw meal, to be burnt in a clinkering kiln at a cement plant, the process includes: a) decarbonation of particles of raw meal, in a fluidized bed heat exchanger, the particles being suspended in a rising carrier gas including carbon dioxide, the fluidized bed heat exchanger having a solid heat carrier circulating counter-current relative to the carrier gas, to provide an effluent gas including carbon dioxide and decarbonated raw meal; b) separating the effluent gas and the decarbonated raw meal c) separating the effluent gas into a first and second part; cooling the first part of the effluent gas and recycling to provide carrier gas, d) isolating the second part of effluent gas e) recovering and re-heating the heat carrier and recirculating to step (a).
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: April 26, 2016
    Assignees: LAFARGE, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE (INPT), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Michel Gimenez, Mehrdji Hemati
  • Patent number: 9321684
    Abstract: A cement clinker manufacturing plant that includes a plant for producing purified syngas, obtained from solid waste, and process for transferring ash recovered from the ash pan of the gasifier to at least one inlet of the feedstock conversion device, which the plant includes, and/or of the furnace for the purpose of incorporating said ash into the feedstock; and a process for conveying the purified syngas to the main tuyere of the furnace and/or to at least one inlet of the feedstock conversion device.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: April 26, 2016
    Assignee: VICAT
    Inventors: Francois Hue, Michel Pasquier, Martine Pasquier, Philippe Lac
  • Patent number: 9321685
    Abstract: A gypsum composition includes a calcined gypsum and a starch urea phosphate.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: April 26, 2016
    Assignee: YOSHINO GYPSUM CO., LTD.
    Inventors: Yuji Ataka, Yosuke Sato
  • Patent number: 9321686
    Abstract: The invention relates to coating compositions, treated reinforced fibers, reinforced asphalt and portland cement concrete and methods for producing the same. The coating compositions include monomer, prepolymer or mixtures thereof, and graft initiator. The monomer and/or prepolymer include at least one functional group selected from the group consisting of hydroxyl, carboxyl, amino and ester. The graft initiator includes metallic salt.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: April 26, 2016
    Assignee: Forta Corporation
    Inventors: Jeffrey B. Lovett, Clifford Norman MacDonald, Daniel T. Biddle
  • Patent number: 9321687
    Abstract: A method for making a low-alkali fly ash cement includes forming a mixture of class C fly ash and an aqueous solution and forming low-alkali fly ash cement from the mixture. The aqueous solution has an alkali at a molar concentration between about 0.002 M and about 2 M. A low-alkali fly ash cement includes class C fly ash and an alkali activating agent. The low-alkali fly ash cement contains between about 3×10?4 wt % alkali activating agent and about 2 wt % alkali activating agent. A method for making fly ash cement includes forming a mixture of class C fly ash and water, wet pressing the mixture and forming fly ash cement from the mixture by curing the mixture at a temperature between about 60° C. and about 90° C.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: April 26, 2016
    Assignee: University of North Dakota
    Inventors: Surojit Gupta, M. Faisal Riyad
  • Patent number: 9321688
    Abstract: Disclosed is a method for preparing polycrystalline aluminum oxynitride having enhanced transparency, and preparing polycrystalline aluminum oxynitride by sintering a powder mixture of Al2O3 and AlN under atmospheric pressure, wherein the content of AlN is set to 17 to 26 mol %, a first sintering is performed at 1,575° C. to 1,675° C. so as to enable raw-material powders to have a relative density of 95% or higher, and a second sintering is performed so as to enable the raw-material powders to have a higher relative density.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: April 26, 2016
    Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YEUNGNAM UNIVERSITY
    Inventors: Jae Hyung Lee, Ji Hye Kim, Bo Hoon Han, In Chul Jung
  • Patent number: 9321689
    Abstract: A mold (30), which has a first region (10) comprising an electroceramic material and a second region (20) comprising a structural ceramic material, is provided. A heating device with this mold is also specified. Furthermore, a method for producing a mold is provided.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: April 26, 2016
    Assignee: EPCOS AG
    Inventors: Jan Ihle, Werner Kahr, Bernhard Steinberger
  • Patent number: 9321690
    Abstract: A sintered material based on silicon carbide (SiC) reactively sintered between 1,100° C. and 1,700° C. to form a silicon nitride binder (Si3N4), intended in particular for fabricating an aluminum electrolysis cell, including 0.05% to 1.5% of boron, the Si3N4/SiC weight ratio being in the range 0.05 to 0.45. Application, in particular, to an electrolysis cell.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: April 26, 2016
    Assignee: SAINT-GOBAIN CENTRE DE RECHERCHES ET D'ETUDES EUROPEEN
    Inventors: Eric Jorge, Olivier Marguin, Lionel Moitrier, Olivier Citti
  • Patent number: 9321691
    Abstract: A product obtained by solid-phase sintering of a silicon carbide powder and of a sintering additive, the product having a relative density of greater than 98.5% and including: more than 92% by weight of SiC present in the form of grains, less than 2% by weight of elemental oxygen, less than 6% by weight, in total, of other elements, wherein more than 10% by number of the SiC grains, on the basis of the total number of the grains, have an elongation factor F of greater than 3 (F>3), wherein more than 50% by number of the grains, the elongation factor F of which is greater than 3, have a width of greater than 3 micrometers, and wherein the other SiC grains in the product have a mean equivalent diameter of greater than 1 micrometer and less than 20 micrometers.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: April 26, 2016
    Assignees: SAINT-GOBAIN CENTRE DE RECHERCHES ET D'ETUDES EUROPEEN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Gilles Rossiquet, Eric Jorge
  • Patent number: 9321692
    Abstract: Production of pore-free carbon/carbon-silicon carbide composite materials with mechanical properties making them suitable for use in such applications as the production of aircraft landing system brake components including brake discs. The method includes: providing a porous carbon-carbon composite preform; surrounding the porous carbon-carbon composite preform with silicon powder to form an intermediate construct; applying a uniaxial load to the construct; applying direct electrical current to an assembly containing the loaded construct of porous carbon-carbon preform surrounded by silicon powder, thereby melting the silicon powder and infiltrating the pores of the carbon-carbon preform with liquid silicon; and initiating a combustion-type reaction between the silicon and carbon in the preform, thereby forming silicon carbide in the preform.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: April 26, 2016
    Assignees: Honeywell International Inc., The University of Notre Dame du Lac
    Inventors: Manuel Koucouthakis, Douglas J. Steinke, Alexander Mukasyan, Jeremiah D. E. White
  • Patent number: 9321694
    Abstract: A porous discriminating layer is formed on a ceramic support having at least one porous wall by (a) establishing a flow of a gas stream containing highly porous particles through the support to deposit a layer of the highly porous particles of a ceramic or ceramic precursor onto wall(s) of the support and (b) calcining said deposited layer to form the discriminating layer. This method is an inexpensive and effective route to forming a discriminating layer onto the porous wall.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: April 26, 2016
    Assignee: Dow Global Technologies LLC
    Inventors: Aleksander J. Pyzik, Jun Cai, Andrey N. Soukhojak, Robert A. Newman
  • Patent number: 9321695
    Abstract: The invention provides a method for manufacturing a glass-ceramic composite using natural raw material and waste glasses. The invention provides a method for manufacturing a white glass-ceramic composite using waste glass and a whitening agent. The invention also provides a method for manufacturing a colored glass-ceramic composite using waste glass, the whitening agent and a coloring agent.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: April 26, 2016
    Assignee: King Abdulaziz City for Science and Technology (KACST)
    Inventors: Mohammed A Binhussain, Paolo Colombo, Enrico Bernardo, Majed A Binmajed, Mauro Marangoni, Hamad H Atalasi, Amer M Alajmi
  • Patent number: 9321696
    Abstract: The invention relates to a method for improving the mechanical strength of a ceramic matrix composite material of the SiC/SiC type, this composite material being obtained by (a) forming a fiber preform from 3rd generation silicon carbide fibers and (b) forming a ceramic matrix around the fiber preform, this ceramic matrix comprising silicon carbide. The method comprises a chemical etching treatment of the surface of the fibers by bringing said fibers into contact with a solution comprising an oxidizer, this treatment being carried out before step (a) or between steps (a) and (b).
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: April 26, 2016
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Emilien Buet, Cédric Sauder, Sylvie Poissonnet, Cathie Vix-Guterl
  • Patent number: 9321697
    Abstract: A recombinant microorganism is provided herein, in particular, a recombinant microorganism of the Azotobacteraceae family. The recombinant Azotobacter microorganism is capable of fixing atmospheric nitrogen continuously in the presence of oxygen and externally fixed nitrogen sources. The present invention further provides a process for production of the recombinant microorganism and a composition comprising the recombinant microorganism for use as biofertilizers and/or for use in the preparation of a fertilizer composition. The recombinant microorganism produced by this invention is an environmental friendly, highly beneficial microorganism.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: April 26, 2016
    Assignee: Department of Biotechnology Ministry of Science & Technology+Jawaharlal Nehru University
    Inventors: Hirendra Kumar Das, Umesh Kumar Bageshwar, Madhulika Srivastava
  • Patent number: 9321698
    Abstract: The method is for reaction treatment including: an organic waste in which oxygen is difficult to penetrate and in which a biochemical reaction by microbe is difficult to occur. This method includes: forcedly supplying oxygen to inner parts of the organic waste to elevate, by biochemical reactions, the temperature of the inner parts of the organic waste to which oxygen has been supplied; and maintaining the elevated temperature to continue the biochemical reactions and thereby compost the organic waste. Thereafter, the organic waste which has been composted is held in the presence of oxygen and carbon monoxide to cause an exothermic reaction and thereby reduce the volume of the organic waste or carbonize the waste.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: April 26, 2016
    Inventor: Kazunori Iwabuchi
  • Patent number: 9321699
    Abstract: An oil-based coating for fertilizer granules impregnated with a polymer additive and related methods of applying the oil-based coating. The polymer additive can comprise homopolymers, copolymers, or combinations thereof, including polyethylene homopolymers. The polymer additive increases the viscosity of the oil-based coating, thereby increasing the duration for which the coating is capable of controlling or inhibiting the formation of dust particulates from the fertilizer granules.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 26, 2016
    Assignee: The Mosaic Company
    Inventors: Lawrence Alan Peacock, Timothy Gene Holt, Keith Dewayne Cochran
  • Patent number: 9321700
    Abstract: A method of producing nanoparticles can comprise milling a plurality of milling bodies sufficient to produce the nanoparticles from exterior surfaces of the plurality of milling bodies. In this manner, the milling bodies are simultaneously the milling media and the feedstock for production of nanoparticles such that additional solids are not present during milling. Nanoparticles can be readily formed and optional milling agent and capping agents can be provided to stabilize and/or customize the nanoparticles for a particular application.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: April 26, 2016
    Assignee: University of Utah Research Foundation
    Inventors: Scott L. Anderson, Brandon McMahon, Jesus Paulo L. Perez
  • Patent number: 9321701
    Abstract: The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: April 26, 2016
    Assignee: Genomatica, Inc.
    Inventors: Mark J. Burk, Anthony P. Burgard, Jun Sun, Robin E. Osterhout, Priti Pharkya
  • Patent number: 9321702
    Abstract: Integrated systems are provided for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compositions, from methane using an oxidative coupling of methane system to convert methane to ethylene, followed by conversion of ethylene to selectable higher hydrocarbon products. Integrated systems and processes are provided that process methane through to these higher hydrocarbon products.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: April 26, 2016
    Assignee: Siluria Technologies, Inc.
    Inventors: Greg Nyce, Peter Czerpak, Carlos Faz, Jarod McCormick, William Michalak, Bipinkumar Patel, Guido Radaelli, Tim A. Rappold, Ron Runnebaum, Erik C. Scher, Aihua Zhang, Joel Cizeron
  • Patent number: 9321703
    Abstract: Integrated systems are provided for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compositions, from methane using an oxidative coupling of methane system to convert methane to ethylene, followed by conversion of ethylene to selectable higher hydrocarbon products. Integrated systems and processes are provided that process methane through to these higher hydrocarbon products.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: April 26, 2016
    Assignee: Siluria Technologies, Inc.
    Inventors: Greg Nyce, Peter Czerpak, Carlos Faz, Jarod McCormick, William Michalak, Bipinkumar Patel, Guido Radaelli, Tim A. Rappold, Ron Runnebaum, Erik C. Scher, Aihua Zhang, Joel Cizeron
  • Patent number: 9321704
    Abstract: A cyclohexane dehydrogenation process comprising a step of providing, as a benzene-containing stream, a vapor phase in equilibrium with a liquid phase at a condensation separation system; supplying benzene, hydrogen, and cyclohexane into a dehydrogenation reactor where at least part of the benzene supplied is from the benzene-containing stream. The use of a condensation separation system enables the control of the partial pressure of benzene in the material fed into the dehydrogenation reactor by controlling the temperature of the vapor phase, and hence the control of hydrogen to benzene molar ratio in the dehydrogenation reactor. The process results in a long life of the dehydrogenation catalyst due to reduced coking.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: April 26, 2016
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: James R. Lattner, Christopher L. Becker, Tan-Jen Chen
  • Patent number: 9321705
    Abstract: A process of producing isopropyl benzene which solves the problem of high amount of n-propyl benzene according to the prior art. The process separates the polyisopropyl benzene through a suitable rectification into two streams of relatively lighter and heavier components, wherein the content of diisopropylbenzene in the stream of relatively lighter components is controlled to be at least greater than 95 wt %, and the content of tri-isopropyl benzene in the stream of relatively heavier components is controlled to be at least greater than 0.5 wt %. Such a technical solution subjecting the two streams respectively to the transalkylation solves the problem raised from the prior art, and is useful for the industrial production of isopropyl benzene.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: April 26, 2016
    Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY, SINOPEC
    Inventors: Huanxin Gao, Bin Zhou, Yilun Wei, Ruifang Gu, Hua Fang, Shufang Ji, Hui Yao
  • Patent number: 9321706
    Abstract: Process for the recovery of diene or vinylaromatic monomers from a gas stream, including bringing the gas stream into contact, in an extraction column (C1), with an organic extraction solvent, which absorbs the monomer, and stripping or desorption with an inert gas in (C1), by feeding, at the bottom of (C1) below the feeding of the monomers, a stream of inert gas, a liquid stream having the extraction solvent and the monomer recovered at the bottom of (C1) and an exiting gas stream recovered at the top of (C1), then within a second recovery column C2,recovery of the monomer, wherein the monomer is separated from the extraction solvent by distillation fed with the liquid stream recovered at the bottom of (C1), a stream comprising concentrated monomer(s) recovered at the top of (C2) and a liquid stream having the extraction solvent recovered at the bottom of (C2) and then recycled to the top of (C), the monomer or monomers being dienes, vinylaromatic compounds, or isobutene.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: April 26, 2016
    Assignees: COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN, MICHELIN RECHERCHE ET TECHNIQUE S.A.
    Inventors: Margarita Dorato, Pierre Kiener
  • Patent number: 9321707
    Abstract: Processes for the production of chlorinated propenes are provided. The present processes make use of 1,2-dichloropropane, a by-product in the production of chlorohydrin, as a low cost starting material, alone or in combination with 1,2,3-trichloropropane. At least one chlorination step is conducted in the gas phase. The present processes can also generate anhydrous HCI as a byproduct that can be removed from the process and used as a feedstock for other processes, providing further time and cost savings.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: April 26, 2016
    Assignee: Blue Cube IP LLC
    Inventors: Max M. Tirtowidjojo, John D. Myers
  • Patent number: 9321708
    Abstract: Provided is a purification method for efficiently reducing an undesirable organic compound or compound in (E)-1-chloro-3,3,3-trifluoropropene and thereby obtaining (E)-1-chloro-3,3,3-trifluoropropene with high purity. The purification method of OF-1233E according to the present invention is characterized by bringing a composition containing OF-1233E and at least one organic compound selected from the group consisting of HCFC-142 isomers, HCFC-244fa, HFC-245fa, OF-1234E, OF-1234Z and OF-1233Z into contact with a solid adsorbent.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: April 26, 2016
    Assignee: Central Glass Company, Limited
    Inventors: Hideaki Imura, Naoto Takada, Masamune Okamoto
  • Patent number: 9321709
    Abstract: In a process for producing phenol and cyclohexanone, a feed comprising cyclohexylbenzene is oxidized to produce an oxidation reaction product comprising cyclohexyl-1-phenyl-1-hydroperoxide. At least a portion of the oxidation reaction product is then cleaved to produce a cleavage reaction product comprising phenol, cyclohexanone, and at least one contaminant. At least a portion of the cleavage reaction product is contacted with an acidic material to convert at least a portion of the at least one contaminant to a converted contaminant and thereby produce a modified reaction product.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: April 26, 2016
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Keith H. Kuechler, Francisco M. Benitez
  • Patent number: 9321710
    Abstract: In a process for producing phenol, a composition comprising an alkylaromatic compound is contacted with an oxygen-containing stream in the presence of an oxidation catalyst comprising a cyclic imide under oxidation conditions effective to oxidize 15 wt % or less of the alkylaromatic compound based upon the total weight of the composition and produce an oxidation product comprising unreacted alkylaromatic compound and alkylaromatic hydroperoxide in a molar ratio of 6:1 to 100:1. Thereafter, at least a portion of the oxidation product is contacted with an acidic molecular sieve catalyst under cleavage conditions effective to convert at least a portion of the alkylaromatic hydroperoxide into phenol and cyclohexanone.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: April 26, 2016
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Kun Wang, Roberto Garcia, Jihad M. Dakka, Gabor Kiss
  • Patent number: 9321711
    Abstract: A system for producing high-purity phenol and/or cyclohexanone from cyclohexylbenzene oxidation includes a cyclohexylbenzene feed hydrogenation reactor, a bubble column oxidation reactor, a cyclohexylbenzene hydroperoxide concentrator, a cleavage reactor, and a separation and purification sub-system. The components and the integrated system are designed such that high-purity phenol and/or cyclohexanone can be produced at high energy efficiency.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: April 26, 2016
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Christopher L. Becker, James R. Lattner, Francisco M. Benitez, Charles Morris Smith
  • Patent number: 9321712
    Abstract: The present invention is related to the process for the preparation ospemifene or (Z)-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol (I) and to intermediate compounds used in the process.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: April 26, 2016
    Assignee: FERMION OY
    Inventors: Jan Tois, Ainoliisa Pihko, Arne Grumann
  • Patent number: 9321713
    Abstract: The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin analogs. The present invention also provides pharmaceutical compositions comprising inventive hyperforin analogs. Hyperforin analogs synthesized using the present synthetic method are envisioned useful in the treatment of various conditions, including, but not limited to, depression and conditions characterized by depression, inflammatory skin conditions, diabetes, asthma, chronic obstructive pulmonary disease (COPD), kidney disorders, and ischemic brain damage.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: April 26, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Matthew D. Shair, Brian A. Sparling, David Moebius
  • Patent number: 9321714
    Abstract: A process of making terephthalic acid or a derivative of terephthalic acid is described. The process includes reacting a derivative of 2,5-dimethylfuran, with a dienophile containing an unsaturated 2-carbon unit, in the presence of a catalyst having Brönsted acidity to form a para-xylene derivative; and optionally reacting the para-xylene derivative to terephthalic acid.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: April 26, 2016
    Assignee: UOP LLC
    Inventors: Timothy A. Brandvold, Avram M. Buchbinder, Nancy Iwamoto, Hayim Abrevaya, Phuong T. M. Do
  • Patent number: 9321715
    Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the PUFA product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the PUFA product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said PUFA product bein
    Type: Grant
    Filed: December 24, 2010
    Date of Patent: April 26, 2016
    Assignee: BASF Pharma (Callanish) Limited
    Inventors: Adam Kelliher, Angus Morrison, Anil Oroskar, Rakesh Vikraman Nair Rema, Abhilesh Agarwal
  • Patent number: 9321716
    Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hyperuricemia, gout, dyslipidemia, obesity, urea cycle disorders, hyperglycemia, insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications, macrovascular complications, lipid disorders, prediabetes, obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, and post prandial hyperglycemia.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: April 26, 2016
    Assignee: CELLIX BIO PRIVATE LIMITED
    Inventor: Mahesh Kandula
  • Patent number: 9321717
    Abstract: Disclosed is a method of rapid identification and preparation of a crystalline form of an organic compound by using sub-gram level of said organic compound, comprising the steps of temperature-cycled slurrying, cooling, antisolvent addition and solvent evaporation as the major crystallization steps.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: April 26, 2016
    Assignee: ALLERGAN, INC.
    Inventors: Ke Wu, Gyorgy F. Ambrus, Scott W. Smith
  • Patent number: 9321718
    Abstract: The invention provides a compound which is (a) a phenylamide derivative of formula (I) or a tautomer thereof, or (b) a pharmaceutically acceptable salt, N-oxide, hydrate, prodrug or solvate thereof: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The compounds are useful in the treatment of diseases mediated by HSP90.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: April 26, 2016
    Assignee: CHROMA THERAPEUTICS LTD.
    Inventors: Alastair David Graham Donald, Joanne McDermott, Sanjay Ratilal Patel, David Festus Charles Moffat
  • Patent number: 9321719
    Abstract: The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate (“SNAC”), including two hydrates, a methanol solvate, and an ethanol solvate, of SNAC. More specifically, the present invention provide six polymorphic forms of SNAC (hereafter referred to as Forms I-VI). The present invention also provides an amorphous form of SNAC.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: April 26, 2016
    Assignee: EMISPHERE TECHNOLOGIES, INC.
    Inventors: Halina Levchik, Shingai Majuru, Brahma Singh, Jamila Harris
  • Patent number: 9321720
    Abstract: Process for preparing isocyanates by reacting the corresponding amines with phos-gene comprising (a) providing at least one amine-comprising feed stream and at least one phosgene-comprising feed stream, (b) mixing the feed streams to form at least one reaction mixture in a mixing zone, (c) reacting the at least one reaction mixture in a reaction zone and (d) working-up the product mixture obtained from (c).
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: April 26, 2016
    Assignee: BASF SE
    Inventors: Torsten Mattke, Gerhard Olbert
  • Patent number: 9321721
    Abstract: The present invention relates to compounds of formula I or a pharmaceutically acceptable salts thereof; wherein the variables R1—R5, Ar1, and X are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: April 26, 2016
    Assignee: Allergan, Inc.
    Inventors: Thomas C. Malone, C. Eugene Hull, III
  • Patent number: 9321722
    Abstract: The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: April 26, 2016
    Assignee: UNIVERSITE JOSEPH FOURIER
    Inventors: Jean-Noël Denis, Claude Marcelle Jolivalt, Louis Maurin Max Maurin, Olga Nikolaevna Burchak
  • Patent number: 9321723
    Abstract: A method for preparing 1-adamantyltrimethylammonium methylcarbonate or N,N-dimethyl-3,5-dimethylpiperidinium methylcarbonate is disclosed. The method comprises reacting dimethyl carbonate and 3,5-dimethylpiperidine or a 1-adamantylamine compound and in the presence of water in a sealed vessel at a temperature of from 80 to 200° C. The 1-adamantylamine compound is 1-adamantylamine, 1-adamantylmethylamine, or mixtures thereof.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: April 26, 2016
    Assignee: Johnson Matthey PLC
    Inventor: Richard Charles Bryan
  • Patent number: 9321724
    Abstract: This invention relates to certain heteroaryl compounds which may be used as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of parasitic infections such as helminth infections and the treatment of parasitosis caused by such infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: April 26, 2016
    Assignee: Intervet Inc.
    Inventors: Michael Berger, Marko Eck, Christopher Kern
  • Patent number: 9321725
    Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: April 26, 2016
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Mark Thomas Miller, Jason McCartney, Sara Sabina Hadida-Ruah, Jinglan Zhou
  • Patent number: 9321726
    Abstract: The invention relates to a process for the preparation of Roflumilast by reaction of an activated form of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid with an activating agent selected from (a) carbonyldiimidazole (CDI), (b) 1,1?-carbonyl-di-(1,2,4-triazol) (CDT), (c) 1,1?-carbonyl-bis-(2-methylimidazol), (d), 1?-carbonyl-dipyperidin, (e) N,N?-dicyclohexylcarbodiimide (DCC), (f) N,N?-diisopropylcarbodiimide (DIC), (g) 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and a combination of one of the previous (a)-(g) with (h) N-hydroxysuccinimide or (i) N-hydroxyphthalimide, and the subsequent reaction with 3,5-dichloropyridine-4-amine in the presence of an inorganic base. The invention also relates to the synthesis intermediates.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: April 26, 2016
    Assignee: Interquim, S.A.
    Inventors: Josep Salaet Ferre, Francisco Marquillas Olondriz
  • Patent number: 9321727
    Abstract: The invention relates to a compound of formula (I) Wherein R1, R2, R3 and R4 are defined as in the description and in the claims. The said compounds of the invention are preferential agoniste of the Carsonabinocid Receptor 2 and thus useful as medicaments and may be used in treatment of chronic pain, atherosclerosis, ischemic/reperfusion injury and other related diseases. A representative compound of this invention is 6-cyclopropylmethoxy-5-(tetrahydro-pyradine-2-carboxglic acid [1-methyl-1-(5-methyl-(1,2,4]oxadiazol-3-yl)-ethyl)-amide.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: April 26, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Caterina Bissantz, Uwe Grether, Paul Hebeisen, Atsushi Kimbara, Qingping Liu, Matthias Nettekoven, Marco Prunotto, Stephan Roever, Mark Rogers-Evans, Tanja Schulz-Gasch, Christoph Ullmer, Zhiwei Wang, Wulun Yang
  • Patent number: 9321728
    Abstract: The present invention relates to a beta-alanine derivative, pharmaceutically acceptable salts thereof, and a pharmaceutical composition including the same as an active ingredient. The novel beta-alanine derivative and pharmaceutically acceptable salts thereof according to the present invention may effectively inhibit the activity of DGAT1, which is an enzyme serving as a catalyst in the final step of the synthesis of neutral lipids, to thereby be effectively used as a pharmaceutical composition for preventing or treating various lipid metabolism-related disorders selected from the group consisting of obesity, dyslipidemia, fatty liver, insulin resistance syndrome, and hepatitis.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: April 26, 2016
    Assignees: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, HANDOK PHARMACEUTICALS CO., LTD.
    Inventors: Jin Hee Ahn, H. S. Pagire, Sang Dal Rhee, Ki Young Kim, Won Hoon Jung, Myung-Ae Bae, Jin Sook Song, Kwang-Rok Kim, Hyun Jung Kwak
  • Patent number: 9321729
    Abstract: Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: April 26, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: John M. Keith, Michael A. Letavic, Kiev S. Ly, Neelakandha S. Mani, John E. Mills, Chennagiri R. Pandit, Frank J. Villani, Hua Zhong
  • Patent number: 9321730
    Abstract: The present invention relates methods of preparing quinoline derivative compounds, and administering such compounds in the treatment of solid and non-solid tumors, notably on liver cancer.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: April 26, 2016
    Assignee: The Hong Kong Polytechnic University
    Inventors: Albert Sun-chi Chan, Johnny Cheuk-on Tang, Kim-hung Lam, Chung-hin Chui, Stanton Hon-lung Kok, Sau Hing Chan, Filly Cheung, Roberto Gambari, Chor Hing Cheng
  • Patent number: 9321731
    Abstract: This invention provides compounds of formula (I): wherein R1, R2, G, m, n, p and q have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: April 26, 2016
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Christopher Blackburn, Jeffrey P. Ciavarri, Kenneth M. Gigstad, He Xu