Patents Issued in April 26, 2016
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Patent number: 9321681Abstract: A method for making geopolymer cementitious binder compositions for cementitious products such as concrete, precast construction elements and panels, mortar and repair materials, and the like is disclosed. The geopolymer cementitious compositions of some embodiments are made by mixing a synergistic mixture of thermally activated aluminosilicate mineral, calcium aluminate cement, a calcium sulfate and a chemical activator with water.Type: GrantFiled: March 15, 2013Date of Patent: April 26, 2016Assignee: UNITED STATES GYPSUM COMPANYInventor: Ashish Dubey
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Patent number: 9321682Abstract: The present invention relates to building materials, in particular a method for the production of a binder for concrete, mortar or plaster, and a binder produced according to this method as well the use thereof.Type: GrantFiled: June 10, 2013Date of Patent: April 26, 2016Assignee: HEIDELBERGCEMENT AGInventors: Mohsen Ben Haha, Tim Link, Frank Bellmann, Horst-Michael Ludwig
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Patent number: 9321683Abstract: A process for decarbonation of particles of raw meal, to be burnt in a clinkering kiln at a cement plant, the process includes: a) decarbonation of particles of raw meal, in a fluidized bed heat exchanger, the particles being suspended in a rising carrier gas including carbon dioxide, the fluidized bed heat exchanger having a solid heat carrier circulating counter-current relative to the carrier gas, to provide an effluent gas including carbon dioxide and decarbonated raw meal; b) separating the effluent gas and the decarbonated raw meal c) separating the effluent gas into a first and second part; cooling the first part of the effluent gas and recycling to provide carrier gas, d) isolating the second part of effluent gas e) recovering and re-heating the heat carrier and recirculating to step (a).Type: GrantFiled: May 11, 2012Date of Patent: April 26, 2016Assignees: LAFARGE, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE (INPT), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Michel Gimenez, Mehrdji Hemati
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Patent number: 9321684Abstract: A cement clinker manufacturing plant that includes a plant for producing purified syngas, obtained from solid waste, and process for transferring ash recovered from the ash pan of the gasifier to at least one inlet of the feedstock conversion device, which the plant includes, and/or of the furnace for the purpose of incorporating said ash into the feedstock; and a process for conveying the purified syngas to the main tuyere of the furnace and/or to at least one inlet of the feedstock conversion device.Type: GrantFiled: October 27, 2011Date of Patent: April 26, 2016Assignee: VICATInventors: Francois Hue, Michel Pasquier, Martine Pasquier, Philippe Lac
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Patent number: 9321685Abstract: A gypsum composition includes a calcined gypsum and a starch urea phosphate.Type: GrantFiled: May 21, 2013Date of Patent: April 26, 2016Assignee: YOSHINO GYPSUM CO., LTD.Inventors: Yuji Ataka, Yosuke Sato
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Patent number: 9321686Abstract: The invention relates to coating compositions, treated reinforced fibers, reinforced asphalt and portland cement concrete and methods for producing the same. The coating compositions include monomer, prepolymer or mixtures thereof, and graft initiator. The monomer and/or prepolymer include at least one functional group selected from the group consisting of hydroxyl, carboxyl, amino and ester. The graft initiator includes metallic salt.Type: GrantFiled: March 13, 2014Date of Patent: April 26, 2016Assignee: Forta CorporationInventors: Jeffrey B. Lovett, Clifford Norman MacDonald, Daniel T. Biddle
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Patent number: 9321687Abstract: A method for making a low-alkali fly ash cement includes forming a mixture of class C fly ash and an aqueous solution and forming low-alkali fly ash cement from the mixture. The aqueous solution has an alkali at a molar concentration between about 0.002 M and about 2 M. A low-alkali fly ash cement includes class C fly ash and an alkali activating agent. The low-alkali fly ash cement contains between about 3×10?4 wt % alkali activating agent and about 2 wt % alkali activating agent. A method for making fly ash cement includes forming a mixture of class C fly ash and water, wet pressing the mixture and forming fly ash cement from the mixture by curing the mixture at a temperature between about 60° C. and about 90° C.Type: GrantFiled: July 3, 2013Date of Patent: April 26, 2016Assignee: University of North DakotaInventors: Surojit Gupta, M. Faisal Riyad
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Patent number: 9321688Abstract: Disclosed is a method for preparing polycrystalline aluminum oxynitride having enhanced transparency, and preparing polycrystalline aluminum oxynitride by sintering a powder mixture of Al2O3 and AlN under atmospheric pressure, wherein the content of AlN is set to 17 to 26 mol %, a first sintering is performed at 1,575° C. to 1,675° C. so as to enable raw-material powders to have a relative density of 95% or higher, and a second sintering is performed so as to enable the raw-material powders to have a higher relative density.Type: GrantFiled: February 28, 2012Date of Patent: April 26, 2016Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YEUNGNAM UNIVERSITYInventors: Jae Hyung Lee, Ji Hye Kim, Bo Hoon Han, In Chul Jung
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Patent number: 9321689Abstract: A mold (30), which has a first region (10) comprising an electroceramic material and a second region (20) comprising a structural ceramic material, is provided. A heating device with this mold is also specified. Furthermore, a method for producing a mold is provided.Type: GrantFiled: July 24, 2009Date of Patent: April 26, 2016Assignee: EPCOS AGInventors: Jan Ihle, Werner Kahr, Bernhard Steinberger
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Patent number: 9321690Abstract: A sintered material based on silicon carbide (SiC) reactively sintered between 1,100° C. and 1,700° C. to form a silicon nitride binder (Si3N4), intended in particular for fabricating an aluminum electrolysis cell, including 0.05% to 1.5% of boron, the Si3N4/SiC weight ratio being in the range 0.05 to 0.45. Application, in particular, to an electrolysis cell.Type: GrantFiled: February 5, 2009Date of Patent: April 26, 2016Assignee: SAINT-GOBAIN CENTRE DE RECHERCHES ET D'ETUDES EUROPEENInventors: Eric Jorge, Olivier Marguin, Lionel Moitrier, Olivier Citti
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Patent number: 9321691Abstract: A product obtained by solid-phase sintering of a silicon carbide powder and of a sintering additive, the product having a relative density of greater than 98.5% and including: more than 92% by weight of SiC present in the form of grains, less than 2% by weight of elemental oxygen, less than 6% by weight, in total, of other elements, wherein more than 10% by number of the SiC grains, on the basis of the total number of the grains, have an elongation factor F of greater than 3 (F>3), wherein more than 50% by number of the grains, the elongation factor F of which is greater than 3, have a width of greater than 3 micrometers, and wherein the other SiC grains in the product have a mean equivalent diameter of greater than 1 micrometer and less than 20 micrometers.Type: GrantFiled: May 17, 2013Date of Patent: April 26, 2016Assignees: SAINT-GOBAIN CENTRE DE RECHERCHES ET D'ETUDES EUROPEEN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Gilles Rossiquet, Eric Jorge
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Patent number: 9321692Abstract: Production of pore-free carbon/carbon-silicon carbide composite materials with mechanical properties making them suitable for use in such applications as the production of aircraft landing system brake components including brake discs. The method includes: providing a porous carbon-carbon composite preform; surrounding the porous carbon-carbon composite preform with silicon powder to form an intermediate construct; applying a uniaxial load to the construct; applying direct electrical current to an assembly containing the loaded construct of porous carbon-carbon preform surrounded by silicon powder, thereby melting the silicon powder and infiltrating the pores of the carbon-carbon preform with liquid silicon; and initiating a combustion-type reaction between the silicon and carbon in the preform, thereby forming silicon carbide in the preform.Type: GrantFiled: July 31, 2009Date of Patent: April 26, 2016Assignees: Honeywell International Inc., The University of Notre Dame du LacInventors: Manuel Koucouthakis, Douglas J. Steinke, Alexander Mukasyan, Jeremiah D. E. White
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Patent number: 9321694Abstract: A porous discriminating layer is formed on a ceramic support having at least one porous wall by (a) establishing a flow of a gas stream containing highly porous particles through the support to deposit a layer of the highly porous particles of a ceramic or ceramic precursor onto wall(s) of the support and (b) calcining said deposited layer to form the discriminating layer. This method is an inexpensive and effective route to forming a discriminating layer onto the porous wall.Type: GrantFiled: August 17, 2011Date of Patent: April 26, 2016Assignee: Dow Global Technologies LLCInventors: Aleksander J. Pyzik, Jun Cai, Andrey N. Soukhojak, Robert A. Newman
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Patent number: 9321695Abstract: The invention provides a method for manufacturing a glass-ceramic composite using natural raw material and waste glasses. The invention provides a method for manufacturing a white glass-ceramic composite using waste glass and a whitening agent. The invention also provides a method for manufacturing a colored glass-ceramic composite using waste glass, the whitening agent and a coloring agent.Type: GrantFiled: January 8, 2013Date of Patent: April 26, 2016Assignee: King Abdulaziz City for Science and Technology (KACST)Inventors: Mohammed A Binhussain, Paolo Colombo, Enrico Bernardo, Majed A Binmajed, Mauro Marangoni, Hamad H Atalasi, Amer M Alajmi
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Patent number: 9321696Abstract: The invention relates to a method for improving the mechanical strength of a ceramic matrix composite material of the SiC/SiC type, this composite material being obtained by (a) forming a fiber preform from 3rd generation silicon carbide fibers and (b) forming a ceramic matrix around the fiber preform, this ceramic matrix comprising silicon carbide. The method comprises a chemical etching treatment of the surface of the fibers by bringing said fibers into contact with a solution comprising an oxidizer, this treatment being carried out before step (a) or between steps (a) and (b).Type: GrantFiled: December 21, 2012Date of Patent: April 26, 2016Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Emilien Buet, Cédric Sauder, Sylvie Poissonnet, Cathie Vix-Guterl
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Patent number: 9321697Abstract: A recombinant microorganism is provided herein, in particular, a recombinant microorganism of the Azotobacteraceae family. The recombinant Azotobacter microorganism is capable of fixing atmospheric nitrogen continuously in the presence of oxygen and externally fixed nitrogen sources. The present invention further provides a process for production of the recombinant microorganism and a composition comprising the recombinant microorganism for use as biofertilizers and/or for use in the preparation of a fertilizer composition. The recombinant microorganism produced by this invention is an environmental friendly, highly beneficial microorganism.Type: GrantFiled: March 4, 2013Date of Patent: April 26, 2016Assignee: Department of Biotechnology Ministry of Science & Technology+Jawaharlal Nehru UniversityInventors: Hirendra Kumar Das, Umesh Kumar Bageshwar, Madhulika Srivastava
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Patent number: 9321698Abstract: The method is for reaction treatment including: an organic waste in which oxygen is difficult to penetrate and in which a biochemical reaction by microbe is difficult to occur. This method includes: forcedly supplying oxygen to inner parts of the organic waste to elevate, by biochemical reactions, the temperature of the inner parts of the organic waste to which oxygen has been supplied; and maintaining the elevated temperature to continue the biochemical reactions and thereby compost the organic waste. Thereafter, the organic waste which has been composted is held in the presence of oxygen and carbon monoxide to cause an exothermic reaction and thereby reduce the volume of the organic waste or carbonize the waste.Type: GrantFiled: March 25, 2009Date of Patent: April 26, 2016Inventor: Kazunori Iwabuchi
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Patent number: 9321699Abstract: An oil-based coating for fertilizer granules impregnated with a polymer additive and related methods of applying the oil-based coating. The polymer additive can comprise homopolymers, copolymers, or combinations thereof, including polyethylene homopolymers. The polymer additive increases the viscosity of the oil-based coating, thereby increasing the duration for which the coating is capable of controlling or inhibiting the formation of dust particulates from the fertilizer granules.Type: GrantFiled: March 14, 2013Date of Patent: April 26, 2016Assignee: The Mosaic CompanyInventors: Lawrence Alan Peacock, Timothy Gene Holt, Keith Dewayne Cochran
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Patent number: 9321700Abstract: A method of producing nanoparticles can comprise milling a plurality of milling bodies sufficient to produce the nanoparticles from exterior surfaces of the plurality of milling bodies. In this manner, the milling bodies are simultaneously the milling media and the feedstock for production of nanoparticles such that additional solids are not present during milling. Nanoparticles can be readily formed and optional milling agent and capping agents can be provided to stabilize and/or customize the nanoparticles for a particular application.Type: GrantFiled: August 6, 2012Date of Patent: April 26, 2016Assignee: University of Utah Research FoundationInventors: Scott L. Anderson, Brandon McMahon, Jesus Paulo L. Perez
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Patent number: 9321701Abstract: The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.Type: GrantFiled: February 2, 2012Date of Patent: April 26, 2016Assignee: Genomatica, Inc.Inventors: Mark J. Burk, Anthony P. Burgard, Jun Sun, Robin E. Osterhout, Priti Pharkya
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Patent number: 9321702Abstract: Integrated systems are provided for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compositions, from methane using an oxidative coupling of methane system to convert methane to ethylene, followed by conversion of ethylene to selectable higher hydrocarbon products. Integrated systems and processes are provided that process methane through to these higher hydrocarbon products.Type: GrantFiled: July 1, 2015Date of Patent: April 26, 2016Assignee: Siluria Technologies, Inc.Inventors: Greg Nyce, Peter Czerpak, Carlos Faz, Jarod McCormick, William Michalak, Bipinkumar Patel, Guido Radaelli, Tim A. Rappold, Ron Runnebaum, Erik C. Scher, Aihua Zhang, Joel Cizeron
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Patent number: 9321703Abstract: Integrated systems are provided for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compositions, from methane using an oxidative coupling of methane system to convert methane to ethylene, followed by conversion of ethylene to selectable higher hydrocarbon products. Integrated systems and processes are provided that process methane through to these higher hydrocarbon products.Type: GrantFiled: July 1, 2015Date of Patent: April 26, 2016Assignee: Siluria Technologies, Inc.Inventors: Greg Nyce, Peter Czerpak, Carlos Faz, Jarod McCormick, William Michalak, Bipinkumar Patel, Guido Radaelli, Tim A. Rappold, Ron Runnebaum, Erik C. Scher, Aihua Zhang, Joel Cizeron
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Patent number: 9321704Abstract: A cyclohexane dehydrogenation process comprising a step of providing, as a benzene-containing stream, a vapor phase in equilibrium with a liquid phase at a condensation separation system; supplying benzene, hydrogen, and cyclohexane into a dehydrogenation reactor where at least part of the benzene supplied is from the benzene-containing stream. The use of a condensation separation system enables the control of the partial pressure of benzene in the material fed into the dehydrogenation reactor by controlling the temperature of the vapor phase, and hence the control of hydrogen to benzene molar ratio in the dehydrogenation reactor. The process results in a long life of the dehydrogenation catalyst due to reduced coking.Type: GrantFiled: December 2, 2013Date of Patent: April 26, 2016Assignee: ExxonMobil Chemical Patents Inc.Inventors: James R. Lattner, Christopher L. Becker, Tan-Jen Chen
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Patent number: 9321705Abstract: A process of producing isopropyl benzene which solves the problem of high amount of n-propyl benzene according to the prior art. The process separates the polyisopropyl benzene through a suitable rectification into two streams of relatively lighter and heavier components, wherein the content of diisopropylbenzene in the stream of relatively lighter components is controlled to be at least greater than 95 wt %, and the content of tri-isopropyl benzene in the stream of relatively heavier components is controlled to be at least greater than 0.5 wt %. Such a technical solution subjecting the two streams respectively to the transalkylation solves the problem raised from the prior art, and is useful for the industrial production of isopropyl benzene.Type: GrantFiled: November 15, 2011Date of Patent: April 26, 2016Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY, SINOPECInventors: Huanxin Gao, Bin Zhou, Yilun Wei, Ruifang Gu, Hua Fang, Shufang Ji, Hui Yao
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Patent number: 9321706Abstract: Process for the recovery of diene or vinylaromatic monomers from a gas stream, including bringing the gas stream into contact, in an extraction column (C1), with an organic extraction solvent, which absorbs the monomer, and stripping or desorption with an inert gas in (C1), by feeding, at the bottom of (C1) below the feeding of the monomers, a stream of inert gas, a liquid stream having the extraction solvent and the monomer recovered at the bottom of (C1) and an exiting gas stream recovered at the top of (C1), then within a second recovery column C2,recovery of the monomer, wherein the monomer is separated from the extraction solvent by distillation fed with the liquid stream recovered at the bottom of (C1), a stream comprising concentrated monomer(s) recovered at the top of (C2) and a liquid stream having the extraction solvent recovered at the bottom of (C2) and then recycled to the top of (C), the monomer or monomers being dienes, vinylaromatic compounds, or isobutene.Type: GrantFiled: April 17, 2012Date of Patent: April 26, 2016Assignees: COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN, MICHELIN RECHERCHE ET TECHNIQUE S.A.Inventors: Margarita Dorato, Pierre Kiener
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Patent number: 9321707Abstract: Processes for the production of chlorinated propenes are provided. The present processes make use of 1,2-dichloropropane, a by-product in the production of chlorohydrin, as a low cost starting material, alone or in combination with 1,2,3-trichloropropane. At least one chlorination step is conducted in the gas phase. The present processes can also generate anhydrous HCI as a byproduct that can be removed from the process and used as a feedstock for other processes, providing further time and cost savings.Type: GrantFiled: September 13, 2013Date of Patent: April 26, 2016Assignee: Blue Cube IP LLCInventors: Max M. Tirtowidjojo, John D. Myers
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Patent number: 9321708Abstract: Provided is a purification method for efficiently reducing an undesirable organic compound or compound in (E)-1-chloro-3,3,3-trifluoropropene and thereby obtaining (E)-1-chloro-3,3,3-trifluoropropene with high purity. The purification method of OF-1233E according to the present invention is characterized by bringing a composition containing OF-1233E and at least one organic compound selected from the group consisting of HCFC-142 isomers, HCFC-244fa, HFC-245fa, OF-1234E, OF-1234Z and OF-1233Z into contact with a solid adsorbent.Type: GrantFiled: January 24, 2013Date of Patent: April 26, 2016Assignee: Central Glass Company, LimitedInventors: Hideaki Imura, Naoto Takada, Masamune Okamoto
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Patent number: 9321709Abstract: In a process for producing phenol and cyclohexanone, a feed comprising cyclohexylbenzene is oxidized to produce an oxidation reaction product comprising cyclohexyl-1-phenyl-1-hydroperoxide. At least a portion of the oxidation reaction product is then cleaved to produce a cleavage reaction product comprising phenol, cyclohexanone, and at least one contaminant. At least a portion of the cleavage reaction product is contacted with an acidic material to convert at least a portion of the at least one contaminant to a converted contaminant and thereby produce a modified reaction product.Type: GrantFiled: August 16, 2011Date of Patent: April 26, 2016Assignee: ExxonMobil Chemical Patents Inc.Inventors: Keith H. Kuechler, Francisco M. Benitez
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Patent number: 9321710Abstract: In a process for producing phenol, a composition comprising an alkylaromatic compound is contacted with an oxygen-containing stream in the presence of an oxidation catalyst comprising a cyclic imide under oxidation conditions effective to oxidize 15 wt % or less of the alkylaromatic compound based upon the total weight of the composition and produce an oxidation product comprising unreacted alkylaromatic compound and alkylaromatic hydroperoxide in a molar ratio of 6:1 to 100:1. Thereafter, at least a portion of the oxidation product is contacted with an acidic molecular sieve catalyst under cleavage conditions effective to convert at least a portion of the alkylaromatic hydroperoxide into phenol and cyclohexanone.Type: GrantFiled: December 15, 2011Date of Patent: April 26, 2016Assignee: ExxonMobil Chemical Patents Inc.Inventors: Kun Wang, Roberto Garcia, Jihad M. Dakka, Gabor Kiss
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Patent number: 9321711Abstract: A system for producing high-purity phenol and/or cyclohexanone from cyclohexylbenzene oxidation includes a cyclohexylbenzene feed hydrogenation reactor, a bubble column oxidation reactor, a cyclohexylbenzene hydroperoxide concentrator, a cleavage reactor, and a separation and purification sub-system. The components and the integrated system are designed such that high-purity phenol and/or cyclohexanone can be produced at high energy efficiency.Type: GrantFiled: February 21, 2014Date of Patent: April 26, 2016Assignee: ExxonMobil Chemical Patents Inc.Inventors: Christopher L. Becker, James R. Lattner, Francisco M. Benitez, Charles Morris Smith
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Patent number: 9321712Abstract: The present invention is related to the process for the preparation ospemifene or (Z)-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol (I) and to intermediate compounds used in the process.Type: GrantFiled: October 17, 2013Date of Patent: April 26, 2016Assignee: FERMION OYInventors: Jan Tois, Ainoliisa Pihko, Arne Grumann
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Patent number: 9321713Abstract: The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin analogs. The present invention also provides pharmaceutical compositions comprising inventive hyperforin analogs. Hyperforin analogs synthesized using the present synthetic method are envisioned useful in the treatment of various conditions, including, but not limited to, depression and conditions characterized by depression, inflammatory skin conditions, diabetes, asthma, chronic obstructive pulmonary disease (COPD), kidney disorders, and ischemic brain damage.Type: GrantFiled: June 1, 2012Date of Patent: April 26, 2016Assignee: President and Fellows of Harvard CollegeInventors: Matthew D. Shair, Brian A. Sparling, David Moebius
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Patent number: 9321714Abstract: A process of making terephthalic acid or a derivative of terephthalic acid is described. The process includes reacting a derivative of 2,5-dimethylfuran, with a dienophile containing an unsaturated 2-carbon unit, in the presence of a catalyst having Brönsted acidity to form a para-xylene derivative; and optionally reacting the para-xylene derivative to terephthalic acid.Type: GrantFiled: December 5, 2014Date of Patent: April 26, 2016Assignee: UOP LLCInventors: Timothy A. Brandvold, Avram M. Buchbinder, Nancy Iwamoto, Hayim Abrevaya, Phuong T. M. Do
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Patent number: 9321715Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the PUFA product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the PUFA product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said PUFA product beinType: GrantFiled: December 24, 2010Date of Patent: April 26, 2016Assignee: BASF Pharma (Callanish) LimitedInventors: Adam Kelliher, Angus Morrison, Anil Oroskar, Rakesh Vikraman Nair Rema, Abhilesh Agarwal
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Patent number: 9321716Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hyperuricemia, gout, dyslipidemia, obesity, urea cycle disorders, hyperglycemia, insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications, macrovascular complications, lipid disorders, prediabetes, obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, and post prandial hyperglycemia.Type: GrantFiled: November 5, 2014Date of Patent: April 26, 2016Assignee: CELLIX BIO PRIVATE LIMITEDInventor: Mahesh Kandula
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Patent number: 9321717Abstract: Disclosed is a method of rapid identification and preparation of a crystalline form of an organic compound by using sub-gram level of said organic compound, comprising the steps of temperature-cycled slurrying, cooling, antisolvent addition and solvent evaporation as the major crystallization steps.Type: GrantFiled: October 23, 2012Date of Patent: April 26, 2016Assignee: ALLERGAN, INC.Inventors: Ke Wu, Gyorgy F. Ambrus, Scott W. Smith
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Patent number: 9321718Abstract: The invention provides a compound which is (a) a phenylamide derivative of formula (I) or a tautomer thereof, or (b) a pharmaceutically acceptable salt, N-oxide, hydrate, prodrug or solvate thereof: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The compounds are useful in the treatment of diseases mediated by HSP90.Type: GrantFiled: June 10, 2011Date of Patent: April 26, 2016Assignee: CHROMA THERAPEUTICS LTD.Inventors: Alastair David Graham Donald, Joanne McDermott, Sanjay Ratilal Patel, David Festus Charles Moffat
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Patent number: 9321719Abstract: The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate (“SNAC”), including two hydrates, a methanol solvate, and an ethanol solvate, of SNAC. More specifically, the present invention provide six polymorphic forms of SNAC (hereafter referred to as Forms I-VI). The present invention also provides an amorphous form of SNAC.Type: GrantFiled: December 23, 2013Date of Patent: April 26, 2016Assignee: EMISPHERE TECHNOLOGIES, INC.Inventors: Halina Levchik, Shingai Majuru, Brahma Singh, Jamila Harris
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Patent number: 9321720Abstract: Process for preparing isocyanates by reacting the corresponding amines with phos-gene comprising (a) providing at least one amine-comprising feed stream and at least one phosgene-comprising feed stream, (b) mixing the feed streams to form at least one reaction mixture in a mixing zone, (c) reacting the at least one reaction mixture in a reaction zone and (d) working-up the product mixture obtained from (c).Type: GrantFiled: October 14, 2011Date of Patent: April 26, 2016Assignee: BASF SEInventors: Torsten Mattke, Gerhard Olbert
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Patent number: 9321721Abstract: The present invention relates to compounds of formula I or a pharmaceutically acceptable salts thereof; wherein the variables R1—R5, Ar1, and X are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.Type: GrantFiled: March 6, 2014Date of Patent: April 26, 2016Assignee: Allergan, Inc.Inventors: Thomas C. Malone, C. Eugene Hull, III
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Patent number: 9321722Abstract: The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.Type: GrantFiled: July 20, 2012Date of Patent: April 26, 2016Assignee: UNIVERSITE JOSEPH FOURIERInventors: Jean-Noël Denis, Claude Marcelle Jolivalt, Louis Maurin Max Maurin, Olga Nikolaevna Burchak
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Patent number: 9321723Abstract: A method for preparing 1-adamantyltrimethylammonium methylcarbonate or N,N-dimethyl-3,5-dimethylpiperidinium methylcarbonate is disclosed. The method comprises reacting dimethyl carbonate and 3,5-dimethylpiperidine or a 1-adamantylamine compound and in the presence of water in a sealed vessel at a temperature of from 80 to 200° C. The 1-adamantylamine compound is 1-adamantylamine, 1-adamantylmethylamine, or mixtures thereof.Type: GrantFiled: August 28, 2014Date of Patent: April 26, 2016Assignee: Johnson Matthey PLCInventor: Richard Charles Bryan
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Patent number: 9321724Abstract: This invention relates to certain heteroaryl compounds which may be used as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of parasitic infections such as helminth infections and the treatment of parasitosis caused by such infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.Type: GrantFiled: March 27, 2013Date of Patent: April 26, 2016Assignee: Intervet Inc.Inventors: Michael Berger, Marko Eck, Christopher Kern
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Patent number: 9321725Abstract: The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1).Type: GrantFiled: October 23, 2013Date of Patent: April 26, 2016Assignee: Vertex Pharmaceuticals IncorporatedInventors: Mark Thomas Miller, Jason McCartney, Sara Sabina Hadida-Ruah, Jinglan Zhou
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Patent number: 9321726Abstract: The invention relates to a process for the preparation of Roflumilast by reaction of an activated form of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid with an activating agent selected from (a) carbonyldiimidazole (CDI), (b) 1,1?-carbonyl-di-(1,2,4-triazol) (CDT), (c) 1,1?-carbonyl-bis-(2-methylimidazol), (d), 1?-carbonyl-dipyperidin, (e) N,N?-dicyclohexylcarbodiimide (DCC), (f) N,N?-diisopropylcarbodiimide (DIC), (g) 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and a combination of one of the previous (a)-(g) with (h) N-hydroxysuccinimide or (i) N-hydroxyphthalimide, and the subsequent reaction with 3,5-dichloropyridine-4-amine in the presence of an inorganic base. The invention also relates to the synthesis intermediates.Type: GrantFiled: October 16, 2013Date of Patent: April 26, 2016Assignee: Interquim, S.A.Inventors: Josep Salaet Ferre, Francisco Marquillas Olondriz
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Patent number: 9321727Abstract: The invention relates to a compound of formula (I) Wherein R1, R2, R3 and R4 are defined as in the description and in the claims. The said compounds of the invention are preferential agoniste of the Carsonabinocid Receptor 2 and thus useful as medicaments and may be used in treatment of chronic pain, atherosclerosis, ischemic/reperfusion injury and other related diseases. A representative compound of this invention is 6-cyclopropylmethoxy-5-(tetrahydro-pyradine-2-carboxglic acid [1-methyl-1-(5-methyl-(1,2,4]oxadiazol-3-yl)-ethyl)-amide.Type: GrantFiled: June 1, 2012Date of Patent: April 26, 2016Assignee: Hoffmann-La Roche Inc.Inventors: Caterina Bissantz, Uwe Grether, Paul Hebeisen, Atsushi Kimbara, Qingping Liu, Matthias Nettekoven, Marco Prunotto, Stephan Roever, Mark Rogers-Evans, Tanja Schulz-Gasch, Christoph Ullmer, Zhiwei Wang, Wulun Yang
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Patent number: 9321728Abstract: The present invention relates to a beta-alanine derivative, pharmaceutically acceptable salts thereof, and a pharmaceutical composition including the same as an active ingredient. The novel beta-alanine derivative and pharmaceutically acceptable salts thereof according to the present invention may effectively inhibit the activity of DGAT1, which is an enzyme serving as a catalyst in the final step of the synthesis of neutral lipids, to thereby be effectively used as a pharmaceutical composition for preventing or treating various lipid metabolism-related disorders selected from the group consisting of obesity, dyslipidemia, fatty liver, insulin resistance syndrome, and hepatitis.Type: GrantFiled: April 25, 2013Date of Patent: April 26, 2016Assignees: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, HANDOK PHARMACEUTICALS CO., LTD.Inventors: Jin Hee Ahn, H. S. Pagire, Sang Dal Rhee, Ki Young Kim, Won Hoon Jung, Myung-Ae Bae, Jin Sook Song, Kwang-Rok Kim, Hyun Jung Kwak
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Patent number: 9321729Abstract: Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.Type: GrantFiled: December 4, 2014Date of Patent: April 26, 2016Assignee: Janssen Pharmaceutica NVInventors: John M. Keith, Michael A. Letavic, Kiev S. Ly, Neelakandha S. Mani, John E. Mills, Chennagiri R. Pandit, Frank J. Villani, Hua Zhong
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Patent number: 9321730Abstract: The present invention relates methods of preparing quinoline derivative compounds, and administering such compounds in the treatment of solid and non-solid tumors, notably on liver cancer.Type: GrantFiled: August 21, 2007Date of Patent: April 26, 2016Assignee: The Hong Kong Polytechnic UniversityInventors: Albert Sun-chi Chan, Johnny Cheuk-on Tang, Kim-hung Lam, Chung-hin Chui, Stanton Hon-lung Kok, Sau Hing Chan, Filly Cheung, Roberto Gambari, Chor Hing Cheng
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Patent number: 9321731Abstract: This invention provides compounds of formula (I): wherein R1, R2, G, m, n, p and q have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.Type: GrantFiled: July 7, 2015Date of Patent: April 26, 2016Assignee: Millennium Pharmaceuticals, Inc.Inventors: Christopher Blackburn, Jeffrey P. Ciavarri, Kenneth M. Gigstad, He Xu