Abstract: A method to make a PTFE skived film capable of exhibiting, with a single layer, sliding properties, barrier properties with regard to a liquid contact surface, and excellent tear resistance during injection molding. This skived film is obtained by cutting a polytetrafluoroethylene block or a modified polytetrafluoroethylene block subjected to a thermal fusion treatment under reduced pressure or subjected to a pressurized thermal fusion treatment after being subjected to fusion under reduced pressure.

Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound.

Abstract: Biodegradable magnesium alloy implantable medical devices are protected to delay onset of corrosion, and thus biodegradability, or to corrode more uniformly. The protection allows for extended effective use of the devices while maintaining biodegradability. Examples of protective coatings include conversion coatings that at least partially remove exposed second phases from a surface of the magnesium alloy and coatings that provide a barrier between water and the surface of the magnesium alloy.

Abstract: Nanomaterials for neural and orthopedic prostheses are disclosed. Composite carbon nanofibers enhance neuronal growth and minimize glial scar tissue formation. Methods and compositions to promote neuronal growth and minimize scar tissue formation during prolonged monitoring and treatment of neural tissue are disclosed. Composite polyurethane carbon nanofiber is a suitable material for neural implant. Composite carbon nanomaterials decrease adhesion of astrocytes and fibroblasts.

Abstract: Provided are micro-needles and a micro-needle patch for transdermal delivery of a pharmaceutical, medical, or cosmetic substance. The micro-needle may include a biocompatible matrix having a micro-needle-like shape; and porous particles provided at at least a portion of a surface or the interior of the biocompatible matrix.

Abstract: According to an aspect of the present invention, medical devices are provided which comprise: (a) a substrate and (b) bioerodable polymeric layer over the substrate that contains (i) one or more biodegradable polymers (ii) one or more therapeutic agents, and (iii) one or more plasticizers.

Abstract: The present invention relates to an implantable material having at least one external surface grafted with a film including carboxylate and sulfonate functions wherein the film is simultaneously synthesized and grafted directly on the external surface by radical reaction of a bifunctional adhesion primer of Formula (I) or by radical reaction of an adhesion primer and a bifunctional polymerizable monomer of Formula (II). The invention also relates to a process for directly synthesizing and grafting of a film according to the invention onto at least one external surface of an implantable material. The invention further relates to the use of a grafted implantable material for the manufacture of an antiproliferative and/or antibacterial implantable medical device. The invention also relates to compounds of Formula (I) and Formula (II).

Abstract: The present invention provides a novel microdermabrasion system that provides safe and effective treatment for skin conditions such as acne, aging and sallow skin, fine wrinkles, surface skin scars, and other visually unappealing cosmetic skin disfigurements. This new invention provides a universal attachment and air flow/suction regulator which permits micro diamond chip based, crystal free microdermabrasion using a variety of standard vacuums and home based cleaning vacuums. Whereas currently available microdermabrasion devices have required a dedicated internal built in vacuum, this new invention allows the use of the universal attachment to most types of vacuums.

Abstract: An aspirator for aspirating venom or poison from a bite or sting. The aspirator includes an elongated housing defined by a circumferential wall delimiting a suction chamber, with the housing having a suction end with a suction opening and the circumferential wall having at least one slot extending axially from the opposite end; a piston member with a piston head connected to a piston rod which is movable between a fully depressed position and a fully retracted position inside the housing; a grip protruding through the at least one slot of the housing for moving the piston member axially inside the housing to adjust aspiration pressure; and an end closure for closing the opposite end of the housing to confine the piston member inside the housing. The suction end of the elongated housing is partly closed by an annular end wall inclining inside the housing and encircling the suction opening.

Abstract: The present invention relates to a heart pump apparatus comprising a turbine pump for assisting the heart of a human patient. The invention is based on the realization that a turbine without a centre axis would improve the capacity of the heart help pump apparatus. The present invention also relates to a turbine pump system for assisting the heart of a human patient. The present invention also relates to operation methods and methods for surgically placing a rotating body of a turbine pump and a stator of a turbine pump in a patient.

Abstract: The invention relates to an intercardiac pump device comprising a pump (11) whose distal end (13) is connected to a cannula (15) which is provided with a suction head (16) for sucking blood. Said strainer is provided with a non-sucking extension (20) for stabilising the position of said pump device in the heart and mechanically prolonging the cannula (15) without deteriorating hydraulic conditions. Said extension is also used in the form of a spacer in order to avoid that the suction head (16) adheres to a cardiac wall.

Abstract: A method for providing animated feedback on an event state in a blood purification device is disclosed. The method includes detecting a pressed state of an active element on a graphical user interface of the device; triggering an event in the device in response to the detection of the pressed state of the active element; tracking the status of the triggered event, wherein said tracking includes detecting a plurality of states of the event, and wherein each detected event state is assigned a feedback representation variant at the active element; and setting the feedback representation variant at the active element as a user feedback indication in accordance with the detected event state. A device for performing the method is also disclosed.

Abstract: The present disclosure relates to capillary dialyzers for blood purification comprising from 85-95% crimped fibres and from 5-15% non-crimped fibres.

Abstract: An extracorporeal blood treatment device is disclosed. The device includes a blood treatment unit connected to an extracorporeal blood circuit, a waste liquid discharge line for evacuating waste treatment liquid from the blood treatment unit, and a collecting container for collecting waste treatment liquid evacuated via the waste liquid discharge line. The collecting container is removably connected to the waste liquid discharge line via a one way valve. A collecting container for a device is also disclosed. The container includes a waste fluid input line, wherein a one way valve is arranged in the waste fluid input line.

Abstract: Disclosed is a filling device of a fluid conducting system of an extracorporeal blood treatment device that includes a spike for connecting to the single fluid connector of a medical fluid container and a manually operable fluid blocking mechanism arranged directly downstream of the spike that fluidly connects with the spike while the filling device is in operation. The fluid blocking mechanism has at least one fluid outlet connector that is adapted so that a line section or hose of the fluid conducting system such as the arterial line section of a blood purification device can be connected to it in a detachable manner while the filling device is in operation.

Abstract: Method for filtering blood plasma flowing through bone marrow of a subject, including: providing an active filtering device having a pressure increasing mechanism and a filter material configured for filtering flowing blood plasma; attaching the active filtering device to bone inside the subject, the bone includes marrow through which flows blood plasma; exposing filter material to flowing blood plasma; applying pressure increasing mechanism so as to create pressure gradient between flowing blood plasma and filter material; filtering flowing blood plasma; and removing excess fluid from flowing blood plasma. During filtration, water and solutes of blood plasma move and pass through filter material, and waste substances of blood plasma are captured and retained by filter material, forming filtered flowing blood plasma.

Abstract: This is to provide a blood filter comprising a porous element; and a copolymer which exists in at least a part of a surface of the porous element, and which contains a recurring unit containing an organic group of the following formula (a) and a recurring unit containing an organic group of the following formula (b), wherein Ua1, Ua2, Ub1, Ub2 and Ub3, and An? are as defined in the present specification and the claims.

Abstract: A connector for fluidly coupling proximal and distal tubular segments of a fluid conduit is provided. In one embodiment, the connector can include a connector body having an outer surface defining a first outer perimeter and an inner surface defining a lumen. The connector can also include a connecting device having an open configuration and a plurality of closed configurations. The connecting device can include first and second members configured to engage each other to secure the fluid conduit to the connector. The connecting device can also include a plurality of closed configurations for securing fluid conduits of different sizes.

Abstract: An on-body injector and method of use including an on-body injector for use with an injection device. The on-body injector includes a bolus reservoir; a bolus injection needle in fluid communication with the bolus reservoir, the bolus injection needle having a bolus injection needle tip aligned with the injection port, the bolus injection needle being slideably biased away from the injection port to define a gap between the bolus injection needle tip and the injection port; and a button operably connected to the bolus injection needle to slide the bolus injection needle along the injection axis. The button is operable to advance the bolus injection needle tip to close the gap and advance the bolus injection needle tip into the injection port. The button is further operable to advance a plunger through the bolus reservoir to deliver a predetermined bolus volume to the patient through the injection flow path.

Abstract: The present invention provides an emergency supply valve to support the in situ administration of a drug to a subject in need thereof, comprising an infusion needle connected to a movable piston, wherein said piston is forwarded by infusion solution unable to pass the regular drug line due to kinking or obstruction thereof, a self-sealing membrane that is disrupted by the infusion needle when the piston is in a forward position, a connecting unit that connects the needle to the regular drug conduit when the needle is in a forward position, and a pressure sensitive mechanism that retracts the piston from the forward position when an increased pressure of the drug supply is normalized and its use for the treatment of subjects in need thereof.

Abstract: An IV holder for securing an IV needle and Luer fitting assembly. The IV holder includes a frame defining an aperture with a first portion and a second portion, the first portion of the aperture further being covered by a transparent window for protecting and securing the IV needle insertion site. The second portion of the aperture is disposed to tit a cylindrical Luer fitting. The holder is adhesively applied to a patient's skin and situated so that the needle insertion site is under the window and the first portion of the aperture while the Luer fitting is disposed within the second portion of the aperture.

Abstract: A bidirectional valve for medical use or the like provides different threshold opening pressures in different directions using a valve seat and flapper construction providing improved characterization in operation in contrast to cross-slit valves often used for bidirectional operation. A valve disk supported in a central annular region provides movable portions engaging in valve seats at a peripheral region and a central region.

Abstract: A monitoring system comprising a monitor is disclosed that utilizes a vibration sensor to monitor the occurrence and properties of an event. The monitor does not require disassembly of the device to be monitored, or interfere with the operation of the device to be monitored, because the monitor is affixed to the exterior of a device to be monitored or a component thereof, or is integrated into the design of the device to be monitored. In a preferred embodiment, the device to be monitored is a drug delivery device, most preferably an inhaler or autoinjector. The monitoring system includes a display device such as a smartphone or tablet computer for analyzing data related to the device to be monitored usage and displaying information to a user, patient and/or caregiver before, during, and after a usage event. Preferred embodiment monitor the inhalation flow rate through an inhaler, and the dose delivered by an injector.

Abstract: A flow rate sensor is provided in a wireless, leadless package. The flow rate sensor includes a MEMs sensor coupled to an ASIC and an antenna. The flow rate sensor is powered by radiation received from a control module adjacent the flow rate sensor. The flow rate sensor is placed within a fluid and monitors the flow rate of the fluid. The control module is not in the fluid and receives flow rate data from the flow rate sensor.

Abstract: A dosing method using a device for transferring and dosing biomedical fluids between hospital containers includes a syringe body containing a biomedical fluid and a piston sealed fitted therein, the syringe body including a first extremity having joining elements to a first container and to a second container, and a second extremity opposite the first extremity, the method including gripping a handle having a coupling seat for fastening to the second extremity; placing first temporary fastening elements between the coupling seat and second extremity; placing second temporary fastening elements between the piston and thrust rod; operating a thrust rod of a motorised element mounted in the handle for pushing the piston; and dosing using control elements mounted on the handle, associated with the motorised element to dose volumetric quantities of biomedical fluid from the first container and dispensing to the second container.

Abstract: Portable or ambulatory infusion devices and systems capable of remotely updating an ambulatory fluid delivery device include safety protocols that verify the status of the ambulatory fluid delivery device before and after a field update of software. Methods of accomplishing the same field update of software are also described.

Abstract: Systems, and methods relate to a medical device receiving a treatment parameter operating point within a first operating region defined by a first set of operating points for which automatic incremental adjustment of a parameter in the current operation is permitted. In an illustrative example, incremental adjustment may use artificial intelligence based on patient feedback and sensor measurement of outcomes. Some exemplary devices may receive a request to alter the current treatment parameter operating point to a second treatment parameter operating point outside the first operating region and in a second operating region in a known safe operation zone, bounded by a known unsafe zone unavailable to the user. In the second operating region, some examples may restrict the step size of incremental adjustments requested by the user. Data may be collected for cloud-based analysis, for example, to facilitate discovery of more effective treatment protocols.

Abstract: The present invention relates to a torsion spring based automatic injection device for apportioning set doses of a liquid drug and which injection device is provided with an End-of-Dose feedback mechanism providing a user with an audible signal once the set dose has been injected. During injection, the scale drum rotates back to its “zero” position under influence of the torsion spring. This rotation is halted shortly before reaching the “zero” position by stopping means. The scale drum is thereafter only allowed to continue rotation and thus reach the “zero” position once the torque applied to the scale drum by the torsion spring surpasses a threshold value.

Abstract: The present invention relates to a drug delivery device (1, 100) comprising a drug expelling mechanism and a spring (10, 110) releasable during use of the drug delivery device (1,100) to convey stored energy to the drug expelling mechanism. The spring (10, 110) comprises a first helical portion (11, 111) and a second helical portion (13, 113) surrounding at least a portion of the first helical portion (11, 111).

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end, operating the syringe to supply the dose of medicament, and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: An injector includes a syringe unit including a syringe that encapsulates an injection objective substance, an ignition device, and a piston, and an activating unit that activates the syringe unit. The syringe unit includes a cylindrical housing, in which the ignition device and the piston are incorporated, and can be installed in a housing space formed in the housing through an opening section provided in a side surface of the housing. The syringe includes a nozzle and a plunger that forms a sealed space for encapsulating the injection objective substance and that is capable of being propelled toward the nozzle by the piston. When the syringe is installed in the housing, the syringe is fixed to dispose the plunger of the syringe in a position opposed to the piston incorporated in the housing.

Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.

Abstract: A syringe can be used to receive fluid from a patient. The syringe can include a syringe body, a first lumen disposed within an internal space of the syringe body, a second lumen disposed within the internal space of the syringe body, and a plunger slideably received along an internal surface of the second lumen. The syringe can also include a stem elongate along a first direction, a handle coupled to the stem, and a needle coupled to the syringe body. The syringe can be configured such that the plunger is moved through the second lumen along a first direction and the fluid is received into the first lumen along a second direction that is opposite the first direction.

Abstract: A syringe having a finger flange and a finger support is provided. The finger flange includes a radially projecting support surface for a finger and is joined to the syringe body of the syringe at its proximal end. In this case, the finger flange is further designed in one piece and includes at least two finger flange elements, which are movably joined with one another.

Abstract: A detent mechanism for controlling translation between two components in a longitudinal direction includes a resilient beam on one of the components and a rhomboid ramp member on the other component. The resilient beam is essentially straight when relaxed and has a first beam head and is arranged to interact in a ramped engagement with respectively one of two ramps. Each ramp is on one longitudinal side of the rhomboid ramp member such that application of a translative force between the components in one longitudinal direction with the first beam head engaged to one of the ramps in a first state deflects the resilient beam in one transversal direction and such that application of a translative force between the components in the other longitudinal direction with the first beam head engaged to the other one of the ramps deflects the resilient beam in the other transversal direction.

Abstract: An injection device comprises an actuator adapted when actuated to cause commencement of an injection sequence; a locking mechanism adapted to be moved between a locked position in which the locking mechanism prevents the actuator from being actuated, and an unlocked position in which the actuator can be actuated to cause commencement of the injection sequence. An indicator is configured to provide a visual indication of whether the locking mechanism is in its locked position or in its unlocked position.

Abstract: Drive and dosing devices for injection devices are disclosed. An embodiment may include a threaded piston rod moveable in a dispensing direction for dispensing a product. A rotation member may be operatively connected to a stop limiter and threadably engaged with the piston rod. Rotation of the rotation member may cause the piston rod to move in the dispensing direction. An embodiment may include a dose knob rotatable for changing a dose. The device may further include a stop element threadably engaged with the piston rod and having a catch. The dose knob may be coupled with the stop element such that during increase of a dose, the stop element is screwed toward the distal end of the piston rod and the catch is moved towards the stop limiter. The stop element prevents increasing a dose when the catch abuts the stop limiter.

Abstract: A piston for use in an injector comprising a cylinder having a longitudinal axis and an inner wall, which piston has a deformable sealing element with a convex surface, which deformable sealing element when the piston is inserted in the cylinder abuts the inner wall of the cylinder at an abutting interface and seals an annular gap between the piston and the inner wall of the cylinder. The abutting interface and the deformable sealing element have axial dimensions parallel with the longitudinal axis. The ratio between the axial dimension of the abutting interface and the axial dimension of the deformable sealing element is in the range between 0.01 and 0.2. In another aspect, an injector includes the piston and is used in a disposable syringe of the piston. The piston can prevent refilling of a syringe.

Abstract: There is provided an injection device 110 comprising a housing 112 adapted to receive a syringe having a discharge nozzle, the syringe being moveable in the housing on actuation of the injection device along a longitudinal axis from a retracted position in which the discharge nozzle is contained within the housing and an extended position in which the discharge nozzle of the syringe extends from the housing through an exit aperture 118 at a distal end of the device, a sliding component 126 which extends, when in a first position, from the aperture, and is movable towards the housing into a second, retracted, position, wherein the sliding component comprises, at its distal end, a removable contact element 220.

Abstract: An injection device comprising a housing adapted to receive a syringe having a discharge nozzle, and a sliding component which protrudes, when in a first position, from the aperture in the housing, wherein the sliding component is movable into the housing into a second position, wherein the sliding component comprises a contact surface located at a first end of the sliding component which protrudes from the housing when the sliding component is in its first position.

Abstract: An injection device comprises an actuator adapted when actuated to cause commencement of an injection sequence; a locking mechanism adapted to be moved between a locked position in which the locking mechanism prevents the actuator from being actuated, and an unlocked position in which the actuator can be actuated to cause commencement of the injection sequence. The locking mechanism comprises a contact portion which in the locked position of the locking mechanism projects against the actuator. The contact portion comprises a curved surface.

Abstract: An injection device comprises a housing adapted to receive a syringe having a discharge nozzle, the syringe being moveable in the housing on actuation of the injection device along a longitudinal axis from a retracted position in which the discharge nozzle is contained within the housing and an extended position in which the discharge nozzle of the syringe extends from the housing through an exit aperture. There is an actuator and a drive adapted to be acted upon by the actuator and in turn act upon the syringe to advance it from its retracted position to its extended position and discharge its contents through the discharge nozzle. A locking mechanism is moveable from an engaged position in a direction into the housing at the exit aperture into a disengaged position. The locking mechanism is adapted to prevent actuation of the device when it is in its engaged position and permit actuation of the device when it is in its disengaged position.

Abstract: The present invention relates to an automatic injection device (1) comprising: a container aligned on a longitudinal axis A and movable between a first position and a second position, in which the needle is inserted, biasing means, laterally spaced with respect to said longitudinal axis A, and coupled to the container for moving it to its second position, via linking means, retaining means (70) for maintaining said biasing means in a first stressed state, deactivating means (80) capable of moving along a transversal direction for releasing said retaining means, triggering means (90) for releasing said deactivating means.

Abstract: An on-body injector and method of use including an on-body injector for use with an injection device. The on-body injector includes a bolus reservoir; a bolus injection needle in fluid communication with the bolus reservoir, the bolus injection needle having a bolus injection needle tip aligned with the injection port, the bolus injection needle being slideably biased away from the injection port to define a gap between the bolus injection needle tip and the injection port; and a button operably connected to the bolus injection needle to slide the bolus injection needle along the injection axis. The button is operable to advance the bolus injection needle tip to close the gap and advance the bolus injection needle tip into the injection port. The button is further operable to advance a plunger through the bolus reservoir to deliver a predetermined bolus volume to the patient through the injection flow path.

Abstract: A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet along a path into the tissue site, and a manual switch for a user interface input.

Abstract: A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

Abstract: A metered dose inhaler (“MDI”) applicator is disclosed that includes a carrier, a housing, an adjuster and a lever. The carrier defines an aperture configured to receive a boot of a MDI. The housing is configured to be assembled with the carrier and to move in a vertical direction within the MID applicator relative to the carrier. The adjuster is configured to move between a locked position and an unlocked position, wherein when the adjuster is in the locked position, the adjuster is configured to prevent the carrier and the housing from moving in one or more directions relative to one another. The lever is pivotally connected to the housing and is configured to transfer a force applied to the lever to a canister of the MDI and to actuate the MDI to dispense an aerosolized medicine.

Abstract: The present invention relates to pharmaceutical powder compositions used by means of inhalation devices. The present invention more particularly relates to a filling method which provides an ideal volume and density for the compositions used in inhalation devices and delivers a desired amount of a fine particle dose to the patient.

Abstract: The present invention provides for an enhanced eductor element that significantly increases the amount of pressure generated at the siphon tube without significantly increasing the flow resistance through the eductor. The invention further provides for breath-actuated inhalation devices comprising the enhanced eductor element as an actuation mechanism.

Abstract: The present invention connects to tubing through which gas flows to a patient. An alert notifies monitoring personnel that oxygen flow to the patient has been interrupted, because the tubing has been disconnected. The invention comprises an adapter that is connected to a gas or oxygen source and a nipple over which the tubing fits and through which oxygen flows to the patient. When the tubing becomes disconnected from the nipple, the oxygen flow actuates an alert. In one embodiment, the invention includes a fixed arm and a swing arm. A latch and a spring that pull the fixed arm and swing arm toward each other connect the two arms. When the tubing becomes disconnected, one arm rotates and activates a switch that sends a signal to an alert that is preferably audible.