Abstract: Methods and compositions for treating obesity and related disorders. The methods include the use of stem cells treated with BMP-2, -4, -5, -6 and/or -7.

Abstract: The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.

Abstract: The present invention provides a novel CXCL12-?2 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.

Abstract: The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.

Abstract: The invention provides knock-in non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing knock-in cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.

Abstract: The invention relates to binding members, especially antibody molecules, which may neutralize the biological effects of human cytomegalovirus (hCMV). The binding members may be useful for the treatment and prophylaxis of hCMV infection.

Abstract: The present invention addresses a need for improved treatments for filovirus infections.

Abstract: The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.

Abstract: The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions. The present invention also relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge. In particular, the present invention relates to a method for the generation of human antigen-specific, high affinity, heavy chain-only antibodies of any class, or mixture of classes and the isolation and expression of fully functional VH antigen-binding domains.

Abstract: Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.

Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.

Abstract: The present invention relates to binding compounds specific for BTLA and uses thereof. More specifically, the invention relates to fully human antibodies that recognize human BTLA and modulate its activity in cancer, inflammatory, and autoimmune disorders.

Abstract: The invention relates to antibodies against HER3 and their use in the treatment of cancer.

Abstract: The present invention relates to biological materials related to c-Met possibly in combination with VEGF and/or EGFR, and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. Methods and kits for assessing the responsiveness of a patient to c-Met therapy are also described and provided.

Abstract: The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.

Abstract: The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to CD37 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.

Abstract: The present invention relates generally to anti-FN14 antibodies. In particular, the anti-FN14 antibodies described herein are useful for the treatment of diseases, such as a variety of cancers, associated with expression of FN14.

Abstract: The present invention relates to an antibody, particularly a monoclonal antibody, which binds to the ErbB3 receptor, compositions comprising such an antibody as well as methods using such an antibody.

Abstract: There is disclosed compositions and methods relating to or derived from anti-ErbB3 antibodies. More specifically, there is disclosed fully human antibodies that bind ErbB3, ErbB3-binding fragments and derivatives of such antibodies, and ErbB3-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having ErbB3 related disorders or conditions, including various inflammatory disorders and various cancers.

Abstract: The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire of species in the family Camelidae, and to antigen binding polypeptides obtained using this technology platform. In particular, the invention provides an antigen binding polypeptide comprising a VH domain and a VL domain, wherein at least one hypervariable loop or complementarity determining region (CDR) in the VH domain or the VL domain is obtained from a VH or VL domain of a species in the family Camelidae.

Abstract: An oligopeptide microarray and methods for the synthesis thereof are presented. Further presented is a microarray on a solid support comprising at least about 10,000 oligopeptide features per cm2 and preferably at least about 50,000 oligopeptide features per cm2.

Abstract: A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.

Abstract: The invention relates to sulphated polysaccharides which have the general structure of the constituent polysaccharides of heparin and which have a molecular weight of less than 8000 Daltons, comprising two antithrombin III-binding hexasaccharide sequences corresponding to formula (I) in which: R1 represents an OH group when the hexasaccharide of formula (I) is located at the reducing end of the polysaccharide, or else R1 represents a bond with another saccharide unit of said polysaccharide; R2 represents a hydrogen atom when the hexasaccharide of formula (I) is located at the non-reducing end of the polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit of said hexasaccharide is a double bond, or else R2 represents a bond with another saccharide unit of said polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit is a single bond.

Abstract: A monolithic organic porous body includes a continuous macropore structure that includes cellular macropores that overlap to form openings having an average diameter of 20 to 200 ?m, the monolithic organic porous body having a thickness of 1 mm or more and a total pore volume of 0.5 to 5 ml/g, an area of a skeleton observed within an SEM image of a section of the continuous macropore structure (in a dry state) being 25 to 50%. A monolithic ion exchanger is produced by introducing an ion-exchange group into the monolithic organic porous body. The monolithic organic porous body and the monolithic ion exchanger are chemically stable, have high mechanical strength, and ensure a low pressure loss when fluid passes through. The monolithic organic porous body and the monolithic ion exchanger may be used as an adsorbent having a large adsorption capacity or an ion exchanger having a large ion-exchange capacity.

Abstract: Silica-coated alumina activator-supports, and catalyst compositions containing these activator-supports, are disclosed. Methods also are provided for preparing silica-coated alumina activator-supports, for preparing catalyst compositions, and for using the catalyst compositions to polymerize olefins.

Abstract: Disclosed herein are ethylene-based polymers having low densities and narrow molecular weight distributions, but high melt strengths for blown film processing. Such polymers can be produced by peroxide-treating a metallocene-catalyzed resin.

Abstract: An object of the present invention is to provide a golf ball resin composition excellent in shot feeling and resilience. The golf ball resin composition includes (A) at least one resin component selected from the group consisting of (a-1) a binary copolymer composed of an olefin and an ?,?-unsaturated carboxylic acid having 3 to 8 carbon atoms, (a-2) an ionomer resin consisting of a metal ion-neutralized product of the binary copolymer components, (a-3) a ternary copolymer composed of the binary copolymer components and an ?,?-unsaturated carboxylic acid ester, and (a-4) an ionomer resin consisting of a metal ion-neutralized product of the ternary copolymer components; and (B) a basic metal salt of a fatty acid, and having a storage modulus E? (Pa) and a loss modulus E? (Pa) satisfying a following expression; log(E?/E?2)??5.84 when measured in a tensile mode using a dynamic viscoelasticity measuring apparatus.

Abstract: The present invention provides novel polymers having chelating functionality and comprising units derived from an ethylenically unsaturated aminocarboxylate monomer which comprises units derived from ethylenediamine triacetic acid or its salt and a polymerizable vinyl monomer. The polymerizable vinyl monomer may be selected from (0-, m-, p-)DVBMO, allyl glycidyl ether, and glycidyl (meth)acrylate. The polymer may also comprise units derived from one or more ethylenically unsaturated monomers.

Abstract: Provided herein are processes of preparing sulfonated estolide compounds, and the removal of sulfonate residues from those compounds to provide desulfonated estolide base oils. Exemplary sulfonated estolide compounds include those selected from the formula: wherein z is an integer selected from 0 to 15; q is an integer selected from 0 to 15; x is, independently for each occurrence, an integer selected from 0 to 20; y is, independently for each occurrence, an integer selected 0 to 20; n is equal to or greater than 0; R6 is selected from —OH, optionally substituted alkyl, and optionally substituted aryl; and R2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched, wherein each fatty acid chain residue of said compounds is independently optionally substituted.

Abstract: Chlorinated vinyl chloride resin may be produced through a heat chlorination reaction of an aqueous suspension of vinyl chloride resin in a hermetically sealable reaction vessel, the method including carrying out a first heat chlorination reaction while raising the temperature of an aqueous suspension of a vinyl chloride resin powder to a predetermined temperature within the range of 85° C. to 95° C., and subsequently carrying out a second heat chlorination reaction at the predetermined temperature.

Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.

Abstract: The present invention provides a modified polytetrafluoroethylene fine powder which can be processed into molded articles high in thermal stability, chemical resistance and transparency and for which the extrusion pressure can be lowered. The present invention is a modified polytetrafluoroethylene fine powder, wherein the cylinder extrusion pressure at a reduction ratio of 1600 is not higher than 50 MPa and the haze value of molded article a for measurement formed therefrom is not higher than 60.

Abstract: The present invention provides a thermoplastic lignin polycondensate. The thermoplastic lignin polycondensate produces no fumes and odor even at a normal melt processing temperature. The melt viscosity of the thermoplastic lignin polycondensate can be measured even when heated to 200° C. or more. The thermoplastic lignin polycondensate can be prepared by selectively activating the hydroxyl reactive groups of lignin to suppress the crosslinking reaction of the hydroxyl reactive groups, which allows a linear or grafted linear growth of the lignin polycondensate.

Abstract: A reaction mixture containing a copolymer having a number average molecular weight less than about 4,000 amu and a polydispersity less than about 3 formed in the presence of a free radical initiator and a heated liquid reaction mixture fed with one or more added olefinic monomers, the reaction mixture otherwise consisting essentially of non-homopolymerizable olefinic monomer.

Abstract: A ?-conjugated aromatic/heteroaromatic oligomer-containing vinyl monomer is generally provided, which can include a polymerizable group, a linker group, and a ?-conjugated aromatic/heteroaromatic side chain. The ?-conjugated aromatic/heteroaromatic side chain includes a first cyclopentadiene ring covalently attached to the linker group, a set of second cyclopentadiene rings covalently attached to the first cyclopentadiene ring, and a third cyclopentadiene ring positioned at a terminal end of the ?-conjugated aromatic/heteroaromatic side chain such that the set of second cyclopentadiene rings is positioned between the first cyclopentadiene ring and the third cyclopentadiene ring. Methods are also provided for forming a polymer via polymerizing the ?-conjugated aromatic/heteroaromatic oligomer-containing vinyl monomer, and for grafting a ?-conjugated aromatic/heteroaromatic oligomer-containing polymer onto a surface of a nanomaterial.

Abstract: This invention relates to a method for producing a copolymer of a conjugated diene compound and an unconjugated olefin other than the conjugated diene compound having a high cis-1,4 bond content of a conjugated diene compound portion, and more particularly to a method for producing a copolymer characterized by comprising a step of polymerizing a conjugated diene compound and an unconjugated olefin other than the conjugated diene compound in the presence of a polymerization catalyst composition including at least one complex selected from a metallocene complex represented by the following general formula (I): (wherein M is a lanthanoid element, scandium or yttrium, and CpR is independently a non-substituted or substituted indenyl, and Ra-Rf are independently an alkyl group having a carbon number of 1-3 or a hydrogen atom, and L is a neutral Lewis base, and w is an integer of 0-3) and so on.

Abstract: An olefin-metathesis catalyst is provided. The olefin-metathesis catalyst includes a magnetic carrier, a polymer having formula (I) grafted on the magnetic carrier, and a ruthenium complex loaded on the polymer. A method for preparing low-molecular-weight nitrile butadiene rubber is also provided. In formula (I), one of X, Y and Z is nitrogen atom, the others are carbon atoms, R1 and R2, independently, include hydrogen, ester group, C1-10 alkyl group, C3-8 cycloalkyl group, 4-ring to 8-ring heterocycloalkyl or C6-10 aryl group, R3 includes hydrogen or C1-10 alkyl group, m ranges from 10 to 2,000, and n ranges from 0 to 1,000.

Abstract: The invention relates to thermosetting compositions containing isocyanurate ring(s) prepared through chain extension of an epoxy resin (a) with carboxyl-functional oligomers (b), which are the reaction product of polyols (i) containing one or more isocyanurate ring(s) and polycarboxylic acids or their anhydrides (ii). The polyols (i) containing one or more isocyanurate ring(s) can be prepared from the reactions of tris (2-hydroxyalkyl) isocyanurates with a modifier from a caprolactone or alkylene oxide, or glycidyl ester or glycidyl ether and mixtures thereof. The epoxy-functional thermosetting compositions containing an isocyanurate ring(s) can be further reacted with unsaturated acids, preferably (meth)acrylic acid, to obtain a curable polyacrylate. Both epoxy-functional isocyanurate and acrylate-functional isocyanurate thermosetting compositions can be further modified with a polyisocyanate to produce a composition that is useful as a reactive adhesive, binder or in other applications.

Abstract: The invention relates to an aqueously dispersible epoxy resin E, comprising building blocks derived from an aliphatic polyether polyol A, an epoxy resin B having at least two epoxide groups per molecule, an epoxy resin B? having at least two epoxide groups per molecule, which may be identical to B, or different from B, an epoxy-functional fatty acid ester D, and an aromatic polyol C, a process for the preparation thereof, and a method of use thereof.

Abstract: A salicylic acid salt-containing liquid composition useful as an accelerator for a hardener includes a reaction product of (a) salicylic acid; and (b) at least one amine compound compatible with said salicylic acid such that the composition is in liquid form, the composition has a concentration of salicylic acid at from about 35 weight percent to about 55 weight percent, and the composition has a viscosity in the range of from about 500 mPas to about 20,000 mPa-s at 25° C.; a curable epoxy resin composition containing the salicylic acid salt-containing liquid composition accelerator; and a cured product made from the curable composition.

Abstract: A polymer and an organic light-emitting device including the polymer represented by Formula 1 wherein at least one of a first dihedral angle between an A1 ring of an nth repeating unit and a first aromatic ring of an (n?1)th repeating unit and a second dihedral angle between an A2 ring of the nth repeating unit and a second aromatic ring of a (n+1)th repeating unit is equal to or greater than an angle of ?50% represented by Equation 1.

Abstract: Methods of preparing monodispersed polydopamine nano- or microspheres are provided. The methods comprise providing a solvent system comprising water and at least one alcohol having the formula R—OH, wherein R is selected from the group consisting of optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C3-C6 cycloalkenyl, and optionally substituted C6-C7 aryl; adding dopamine to said solvent system to form a reaction mixture; and agitating said reaction mixture for a time period of 1 to 10 days to form said monodispersed polydopamine nano- or microspheres. Methods of preparing carbon and hollow metal or metal oxide nano- or microspheres using the polydopamine nano- or microspheres are also provided.

Abstract: The present invention is directed toward a series of polyesters synthesized utilizing propane diol with tunable ascetics and performance in cosmetic formulation. These novel propane diol polyesters are designed to have great esthetics in cosmetic formulation. The physical properties and aesthetics of the current invention can be tuned rapidly by controlling the fatty groups, as well as the molecular weight of the polymer. The resulting propane diol polyesters have outstanding aesthetics and physical properties.

Abstract: A method for producing a polymer, including: (i) continuously supplying and bringing at least a first monomer, which is ring-opening polymerizable, and a compressive fluid into contact with each other, to thereby allow the first monomer to carry out ring-opening polymerization to continuously generate an intermediate; and (ii) bringing the intermediate and a second monomer, which is identical to or different from the first monomer in kind, into contact with each other, to thereby allow the intermediate and the second monomer to carry out polymerization.

Abstract: The invention belongs to energy chemical technical field, especially relates to a fluidized bed reactor and a method for preparation of polyoxymethylene dimethyl ethers from dimethoxymethane and paraformaldehyde. The fluidized bed reactor comprises a gas inlet, a gas distributor, a catalyst inlet, a gas outlet, a fluid inlet, a catalyst outlet, a bottom component and an interstage component, a bottom component related gas upward channel, an interstage component related gas upward channel, a fluid outlet, a bottom downcomer and an interstage downcomer.

Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.

Abstract: A disulfide-linked covalent organic polymer and a preparation method thereof are described, and more particularly a disulfide-linked covalent organic polymer prepared by a disulfide formation reaction, a preparation method thereof, and the use of the organic polymer as an organic solvent absorbent. A disulfide-linked covalent organic polymer prepared according to the disclosure may be used as an absorbent capable of selectively absorbing various organic solvents in aqueous solutions or wastewater.