Abstract: The various embodiments disclosed herein relate to procedural space maintenance devices, medical device positioning devices, and devices that provide both procedural space maintenance and device positioning. Further embodiments relate to medical device insertion and/or retraction devices.

Abstract: To accurately position multiple tomographic image. An image processing apparatus includes a detecting unit configured to detect motion of an eye in a plurality of polarization-sensitive tomographic images, based on a predetermined region extracted from the plurality of polarization-sensitive tomographic images of the eye, and a positioning unit configured to position a plurality of tomographic luminance images corresponding to the plurality of polarization-sensitive tomographic images, based on the detected movement.

Abstract: Disclosed are computer implemented methods for testing astigmatism which display differently coloured bars against a contrasting background. In one implementation, parallel coloured bars are separated and joined through various angles of rotation against a constant background. In another implementation one set of bars is formed by variable grating pattern which is rotated within an annulus of solid colour bars, desirably against a contrasting intermediate background and a reference background having a linear grating pattern.

Abstract: Illumination can be evaluated for patient using a system including a housing, an adjustable light source mechanically coupled to the housing and configured to illuminate an object for viewing by the patient on an axis substantially perpendicular to a surface of the object. A user-adjustable input coupled to the adjustable light source is to obtain information from a user indicative of a calibrated illuminance and a color property to be provided by the adjustable light source including providing a range of adjustable illuminance and color properties selectable by the user. The adjustable light source can be configured to provide light having an illuminance in excess of 300 lux, and the housing can be configured to provide a first specified distance between the adjustable light source and the object for viewing and to obstruct viewing of the light source directly by the patient.

Abstract: An optical coherence tomographic apparatus which obtains a tomographic image of an object based on light obtained by combining return light from the object irradiated with measurement light through a first lens and reference light corresponding to the measurement light, the apparatus comprises a scanning unit provided on an optical path of the measurement light and configured to scan the measurement light on the object; a second lens disposed between the scanning unit and the object; an optical path branching unit disposed between the first lens and the second lens and configured to make the optical path of the measurement light branch off to an observation optical path for observation of the object; a dividing unit that splits light emitted from a light source into the measurement light and the reference light; and a focus lens disposed between the dividing and scanning units.

Abstract: A method of reducing jitter error in a laser scanning system adapted to produce a scanned image including a number of lines of an object. The method includes the steps of providing a reference object arranged such that the scanned image produced by the laser scanning system includes a reference image of the reference object, processing the reference image to calculate an error arising from non-repeatable displacement of the lines of the reference image, and adjusting at least one operating parameter of the laser scanning system in response to the calculated error.

Abstract: The human eye is constantly in motion. For many imaging applications in the eye, eye motion on the time scale of the image acquisition distorts the images. For imaging applications where the signal is very low, image distortion is so severe that imaging is impossible. According to an exemplary embodiment of the present disclosure, systems, methods and computer-accessible medium can be provided to determine eye motion in real time, and provide real time correction of the eye motion for secondary imaging methods to provide stable images and permit long integration times of single images to increase the signal to noise.

Abstract: In exemplary implementations of this invention, a bi-ocular apparatus presents visual stimuli to one eye of a human subject in order to relax that eye, while measuring refractive aberration of the subject's other eye. Alternately, a monocular device presents stimuli to relax an eye while testing the same eye. The apparatus induces eye relaxation by displaying virtual objects at varying apparent distances from the subject. For example, the apparatus may do so by (i) changing distance between a backlit film and a lens; (ii) using extra lenses; (iii) using an adaptive lens that changes power; (v) selecting distinct positions in a progressive or multi-focal length lens; (vi) selecting distinct optical depths by fiber optical illumination; (vii) displaying a 3D virtual image at any given apparent depth; or (viii) display both a warped version of the real world and a test image at the same time.

Abstract: A apparatus for automatically detecting a pregnancy status of a patient include a patch for adhering to human skin, a uterine contraction sensor, such as electromyography (EMG), coupled to the patch with at least two electrodes, and an inertial sensor for sensing fetal movement, or Fetal Heart Rate (FHR) sensor, such as Fetal EKG or a Doppler Ultrasound. An electronic circuit is coupled to the patch, the EMG sensor and the inertial sensor, and/or FHR sensor. The circuit provides an output based on a uterine contraction signal from the EMG sensor (or Doppler ultrasound) correlated in time to a fetal movement, and/or fetal heart rate. The apparatus may include a thermometer to aid in automatically providing an indication of a pregnancy complication or ovulation status of the patient, based on the output.

Abstract: Methods, apparatuses, and computer readable mediums for choosing a heart rate monitor for a wearable monitoring device. In a particular embodiment, the wearable monitoring device identifies a location of a wearable monitoring device on a user; selects based on an identification of the location, a heart rate monitor from the plurality of heart rate monitors; and uses the selected heart rate monitor to monitor a heart rate of the user.

Abstract: A system for monitoring the health of an individual by providing biometric sensors attached to or inside the skin of a patient, along with a transmitter connected to the sensors for transmitting data from the sensors to a central monitoring station via a receiver located near the sensors. The sensor system is connected to an RFID tag, which communicates with an RFID reader in a remote location. The RFID tag transmits data from the sensors to the reader through the antenna, and the data is then analyzed by a microprocessor and an alert is communicated to a central monitoring station if the data from the sensors exceeds a preset threshold limit.

Abstract: The present invention provides a hybrid imaging system for imaging a volume of interest of a subject, said hybrid system is characterized by: a. a MRI device; b. a photon transmitter, introducible within the body of an animal; c. at least one imaging photon detector located either within or outside said animal, for detecting fluorescence excited within said animal by said transmitted photons; and d. an image processor adapted to superimpose said MRI image and said at least one photon detector image, generating a rendered MRI image of said volume of interest of the subject. The hybrid system is configured to substantially simultaneously acquire MRI image and in vivo fluorescence image.

Abstract: An apparatus can be provided which can include a laser arrangement which can be configured to provide a laser radiation, and can include an optical cavity. The optical cavity can include a dispersive optical first arrangement which can be configured to receive and disperse at least one first electro-magnetic radiation so as to provide at least one second electro-magnetic radiation. Such cavity can also include an active optical modulator second arrangement which can be configured to receive and modulate the at least one second radiation so as to provide at least one third electro-magnetic radiation. The optical cavity can further include a dispersive optical third arrangement which can be configured to receive and disperse at least one third electro-magnetic radiation so as to provide at least one fourth electro-magnetic radiation.

Abstract: A fluorescence observation apparatus including a light source that radiates illumination light and excitation light; a return-light-image generating portion and a fluorescence-image generating portion that generate a return-light image and a fluorescence image, respectively; a fluorescence detecting portion that detects a fluorescence region in the fluorescence image; a return-light-image adjusting portion that adjusts gradation values of the return-light image; a superimposed-image generating portion that generates a superimposed image by using the return-light image, in which the gradation values have been adjusted, and the fluorescence image; and a coefficient setting portion that sets, in the case in which the fluorescence region is detected, a degree-of-reduction of the gradation values, so that the gradation values of the return-light image are decreased as compared with the case in which the fluorescence region is not detected.

Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

Abstract: An apparatus includes a housing with a flexible wall having an outer side configured to contact an external body surface of an animal and an inner side with a light reflective surface towards an interior of the housing. A light source illuminates the light reflective surface, and an image registering part captures image data representing the light reflective surface. A data processing part receives the image data, and based thereon produces at least one signal indicative of at least one physiological parameter of the animal. The apparatus may be arranged on the animal such that the outer side of the flexible wall contacts a neck region of the animal and the data processing part derives a primary signal representing a chewing related parameter.

Abstract: Disclosed herein are portable handheld devices, systems, and methods for the evaluation of tissue pathology and the evaluation and/or monitoring of tissue regeneration. The handheld devices and systems perform laser speckle and hyperspectral imaging to assess tissue pathology and tissue regeneration. The device and system of the disclosure may also perform 3D surface reconstruction.

Abstract: A view point is set inside a hollow organ, a clip plane crossing an internal cavity of the hollow organ is set in a position spaced apart in a visual line direction from the view point, a field of view from the view point is divided into a first field-of-view range in which the inside of the hollow organ is viewed and a second field-of-view range other than the first field-of-view range, a projection image is acquired using a template which is defined so that an inner wall surface of a large intestine is able to be drawn in the first field-of-view range, a projection image is acquired using a template which is defined so that a contact surface with the inner wall surface of the air region of the large intestine is able to be drawn in the second field-of-view range, and the projection images are connected.

Abstract: Methods and sensor delivery devices for monitoring a fluid pressure within a vascular structure, the devices including an elongated sheath sized for sliding along a guidewire, a sensor assembly including a fiber optic sensor, a housing surrounding the sensor, a first cavity between the distal end of the sensor and a distal aperture of the housing, a filler extending from at least the distal end of the housing distally and tapering inward toward the outer surface of the sheath, a second cavity in the filler with an opening at the outer surface of the filler and adjoining the distal aperture of the housing, and an optical fiber. The sensor delivery device may also include an outer layer that partially covers the second cavity with an aperture over the opening of the second cavity.

Abstract: The invention relates to an acoustic-electric imaging method, which includes: a measurement step during which incident ultrasonic waves having different wavefronts are emitted in a medium 1 to be imaged, and at least one electric sensor is used to capture raw electric signals Erawl(t) respectively during the propagation of the incident waves; a step of forming an image, during which an image of the medium including an electric current map is determined from the raw electric signals Erawl(t).

Abstract: An acoustic imaging apparatus includes an image forming unit including a transducer array that includes a downwardly recessed portion on which a plurality of transducers, which include reception surfaces that receive acoustic waves generated by a subject, are arranged. The image forming unit forms an image based on outputs from the transducers. Impedance matching liquid is disposed on the inner side of the transducer array. A cover member is connected to the vessel and covers the transducer array at a side opposite to a side at which the reception surfaces are arranged so that a vessel and the cover member form a housing space that accommodates the transducers. The transducers are provided with signal lines through which electric signals based on the received acoustic waves are output and which extend from the housing space to the outside through a waterproof member.

Abstract: In an acoustic wave detection probe provided with a light guide section that guides measuring light such that the measuring light is outputted toward a subject and an acoustic wave transducer that detects a photoacoustic wave generated in the subject by the projection of the measuring light, the light guide section includes a homogenizer that flat-tops an energy profile of the measuring light entered from the upstream side of the optical system, a light condensing member that condenses the measuring light transmitted through the homogenizer, and a bundle fiber which includes a plurality of optical fibers and is disposed such that the measuring light transmitted through the light condensing member enters from an entrance end of the bundle fiber.

Abstract: The present application is directed to a system for protecting male reproductive health. An example system may comprise at least a temperature control portion and a monitoring device. The temperature control portion may include a thermal accumulation material to absorb heat generated by male genitalia. The monitoring device may include at least one sensor to sense an internal temperature corresponding to a surface temperature of the male genitalia, and possibly a second sensor to sense a temperature external to the temperature control portion. The monitoring device may compare the internal and/or external temperatures to threshold temperature levels, and may take action based on either/both temperatures being at or above the threshold temperature levels.

Abstract: An infrared thermometer includes: a main unit incorporating an infrared sensor; a proximity sensor for detecting that the main unit has been positioned in proximity to a human body; and a controller which calculates body temperature based on quantity of infrared from the infrared sensor when the proximity sensor has detected positioning of the main unit in proximity to a human body. The proximity sensor includes a ground electrode, and a plurality of segmented electrodes arranged about the perimeter of the ground electrode. The controller measures electrostatic capacitance between the ground electrode and the segmented electrodes when positioned in proximity to a human body, and measures the distance between the main unit and the human body, to thereby detect tilt of the main unit with respect to the human body.

Abstract: Blood glucose measurement methods and apparatuses are provided using multiple body signals. The methods and apparatuses are employed to estimate blood glucose in a noninvasive manner by using a change in the absorbance of glucose according to a blood glucose level and to correct the estimated blood glucose using different types of blood glucose measurement methods. The blood glucose measurement apparatus includes a main body worn on a human body, a first light source provided on an inner surface of the main body, a second light source provided on the inner surface of the main body, a light receiver configured to receive light from the first light source and the second light source, and a calculator configured to calculate a glucose level in blood based on an amount of light received by the light receiver and configured to measure blood glucose.

Abstract: Passive physiological monitoring apparatus and method has a sensor for sensing physiological phenomenon. The sensor is a piezoelectric film of polyvinylidene fluoride. A pad may incorporate the PVDF film. The film converts mechanical energy into voltage signals. A microcomputer is used for recording, analyzing and displaying data from the sensor for on-line assessment and for providing realtime response. The sensor may be an array of sensors provided in a MEDEVAC litter or other patient support for measuring acoustic and hydraulic signals from the body of a patient for field monitoring, hospital monitoring, transport monitoring, home, remote monitoring.

Abstract: A method, apparatus, and/or system for patient wellness monitoring is disclosed. In one step, therapy information specifying one or more medical treatments may be received by a wrist-worn device, the wrist-worn device including a wristband monitoring device and a faceplate device. A regimen for the user may be retrieved, the regimen being based on the received therapy. A notification related to a wellness concern may be generated on the wrist-worn device. Affirmative user input may be received by the faceplate device. One or more sensors may be activated to collect vital sign information of the user and the vital sign information may be received. The user input may be associated with the vital sign information. A wellness index may be calculated using the user input and the vital sign information, the wellness index indicating a degree of wellness of the user. A graphical element indicating the wellness index may be provided on the wrist-worn device.

Abstract: A system and method provide the capability to assess relative fluid flow. A light source is configured to generate a coherent light beam and direct the coherent light beam at an object. A detector is configured to receive light remitted from the object and output image data, and a controller is configured to receive the image data and calculate a relative fluid flow value based on a speckle contrast image of the image data.

Abstract: Impaired intraocular blood flow within vascular beds in the human eye is associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for imaging microcirculation within different intraocular regions. A method to quantify SSADA results was developed and used to detect perfusion changes in early stage ocular disease. Associated embodiments relating to methods for quantitatively measuring blood flow at various intraocular vasculature sites, systems for practicing such methods, and use of such methods and systems for diagnosing certain ocular diseases are herein described.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a medical device for measuring blood pressure. The medical device may include an elongated shaft having a proximal region and a distal region. An optical fiber may extend along the proximal region. The optical fiber may be secured to an inner surface of the shaft. An optical pressure sensor may be coupled to the optical fiber. The optical pressure sensor may be disposed along the distal region. A sealing member may be attached to the optical fiber and may have a surface engaged with the inner surface of the shaft.

Abstract: There is provided a device (100) and method for determining a total probability (Ptot) of Return of Spontaneous Circulation (ROSC) during an associated CPR procedure, which is being performed on an associated patient, comprising an input for receiving a set of photoplethysmograpy data (328, 330) having been obtained from the associated patient during the CPR procedure, and a processor (112) being arranged for carrying out one or more processes according to one or more predetermined algorithms (321, 322, 323, 324) so as to calculate the total probability (Ptot) of ROSC based on the one or more parameters, wherein the one or more processes are each, and/or in combination, being arranged for overcoming challenges derived from the CPR process, such as arbitrary signals not related to return of spontaneous circulation. In embodiments, the device and method relies on a plurality of processes in determining the total probability of ROSC.

Abstract: A wrist device includes a first scale and a first hand, an actuator member configured to control movement of the first hand, at least one processor, and at least one memory including a computer program code. The at least one memory and the computer program code are configured, with the at least one processor, to cause the wrist device to perform operations including, obtaining physiological measurement data of a user, and causing, based on the physiological measurement data, the actuator member to move the first hand to indicate a physiological value on the first scale.

Abstract: A photoelectric sensor retainer and a photoelectric pulse wave measuring apparatus including the same are provided. The photoelectric sensor retainer includes a sensor mounting unit on which a photoelectric sensor having a light-receiving surface is attachable and detachable, the light-receiving surface facing a measuring direction. The photoelectric sensor retainer further includes a pressing unit configured to press an upper surface of the sensor mounting unit in the measuring direction to apply pressure to the sensor mounting unit, and a pedestal including a seating plate configured to support the pressing unit, the seating plate having a principal plane perpendicular to a pressing direction of the pressing unit.

Abstract: Methods, systems, and devices are disclosed for implementing magnetoencephalography (MEG) source imaging. In one aspect, a method includes determining a covariance matrix based on sensor signal data in the time domain or frequency domain, the sensor signal data representing magnetic-field signals emitted by a brain of a subject and detected by MEG sensors in a sensor array surrounding the brain, defining a source grid containing source locations within the brain that generate magnetic signals, the source locations having a particular resolution, in which a number of source locations is greater than a number of sensors in the sensor array, and generating a source value of signal power for each location in the source grid by fitting the selected sensor covariance matrix, in which the covariance matrix is time-independent based on time or frequency information of the sensor signal data.

Abstract: A muscular fatigue determination apparatus includes an information obtaining unit that obtains loads applied to a pedal of a bicycle, rotation speeds of a crank of the bicycle, and myoelectric potentials of a user, the myoelectric potentials and the loads being in a one-to-one relationship, the myoelectric potentials and the rotation speeds being in a one-to-one relationship, and a muscular fatigue information generation unit that generates muscular fatigue information regarding the user on the basis of whether a difference between the myoelectric potentials of the user is larger than a first threshold, each of the myoelectric potentials being associated to a load range that is one of load ranges and to a rotation speed range that is one of rotation speed ranges, each of the loads belonging to one of the load ranges and each of the rotation speed ranges belonging to one of the rotation speed ranges.

Abstract: In a method and system for generating twelve-lead ECG signals based on three differential voltages, each of which is defined as a potential difference between two myoelectric signals sensed respectively by two corresponding electrodes that cooperatively constitute a corresponding differential electrode pair and that are disposed on a user's chest at predetermined specific locations, a signal processor generates the twelve-lead ECG signals using a pre-established dynamic system model that is associated with the specific locations of the electrodes on the user's chest and that is configured with temporal and spatial correlations among twelve leads of an ECG.

Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.

Abstract: Methods for quickly estimating apparent diffusion coefficient probability density functions (ADC PDFs) for each image voxel are provided using a “diffusion reproducibility evaluation and measurement” (DREAM) magnetic resonance sequence. Non-diffusion-weighted (reference) images collected simultaneously have blood oxygenation level dependent (BOLD) sensitivity that can be used for resting-state fMRI data to measure functional connectivity, an unbiased parameter reflecting neurological integrity. ADC coefficient of variation (ADC CV) measurements can be used to isolate and label regions of non-enhancing tumor and predict future enhancement independent of FLAIR, T2, or average ADC maps. Functional diffusion mapping (fDMs) using voxel-wise changes in ADC PDFs can be used to spatially visualize and statistically quantify response to treatment.

Abstract: In a magnetic resonance method and apparatus for determining an item of deformation information of an examination object that exhibits a cyclical movement within an examination subject, a spatial magnetization pattern is generated in an MR scanner, and MR signals are acquired from the subject during at least two cycles of the cyclical movement, with the spatial magnetization exhibiting differences in a subsequent cycle of the movement compared to an earlier cycle. Segmented subsequent MR images are acquired in a subsequent cycle and the examination object is localized therein. This localization of the examination object is then used to localize the examination object in segmented earlier MR images from the earlier cycle, and the item of deformation information is determined in a spatial direction from the segmented earlier MR images.

Abstract: The present invention is a device for obtaining an electrical signal from a patient that corresponds to a meridian. One embodiment of the present invention comprises an ergonomically pistol grip device that reduces fatigue by the placement of the head and motor and other key components. Another embodiment of the invention is the location of a fan and sound-deadening foam to limit the noise and heat to which the user is exposed during operation of the probe. Embodiment is the isolation hood which contains a removable tip and ergonomically design to prevent user fatigue and comfort to the patient.

Abstract: A portable device for measuring a bioimpedance-related property of tissue includes a plurality of electrodes arranged in a pattern on a surface and associated software for measuring bio-impedance related data of localized regions of tissue and calculate health-related parameters based on the measured data. These calculated parameters may be representative of muscular health of the localized tissue region.

Abstract: The present invention is related to a system and method to ensure the reproducibility of the position of the feet and lower parts of the legs, during the Magnetic Resonance Imaging (MRI) studies, to obtain robust quantitative information through the time. The system comprises a device that is inserted into the radiofrequency coils of any MRI equipment. Said device comprises a foot support section, a leg support section and a base adapted to allow that the abovementioned sections be fixed in it. With this device and method, through external and internal markers, quantitative studies of the evolution of pathophysiological phenomena that affect the anatomy and physiology of the feet and lower parts of the legs are performed.

Abstract: A surgical navigation system comprising a signal receiver communicatively coupled to a primary processor, the primary processor programmed to utilize a sequential Monte Carlo algorithm to calculate changes in three dimensional position of an inertial measurement unit mounted to a surgical tool, the processor communicatively coupled to a first memory storing tool data unique to each of a plurality of surgical tools, and a second memory storing a model data sufficient to construct a three dimensional model of an anatomical feature, the primary processor communicatively coupled to a display providing visual feedback regarding the three dimensional position of the surgical tool with respect to the anatomical feature.

Abstract: Disclosed is a glucose measuring apparatus including a pressure measurer hat measures a pressure applied to an object, a near infrared ray (NIR) irradiator that irradiates an NIR to the object if the measured pressure is greater than or equal to a preset value, an NIR receiver that receives at least one of an NIR reflected from the object, a scattered NIR, and an NIR that penetrated the object, and an analyzer that measures the blood glucose level based on the received NIR.

Abstract: An apparatus for neural block determination is provided including processing circuitry configured to receive muscle movement measurements, analyze the muscle movement measurements in a frequency domain, and determine an effectiveness of an anesthetic based on the analysis of the muscle movement measurements in the frequency domain.

Abstract: Methods and apparatuses for detecting when a subject gets up out of bed or out of chair by detecting changes in body flexion angle with respect to a threshold. Also described herein are systems for monitoring one or more subjects each wearing an angle-sensing unit.

Abstract: A patient handling device includes a frame for supporting a patient, a controller, and two alert lights which are activated when a controller detects an alert situation, such as, but not limited to, a patient exiting from the patient handling device. The controller is in communication with the alert lights and operable to monitor an integrated bed exit system. The alert lights are positioned adjacent the foot end corners of the frame and are viewable by a user positioned anywhere within a 270 degree section of a circle defined at the center of the patient handling device. The alert lights include one or more Light Emitting Diodes (LEDs).

Abstract: The invention discloses a Bluetooth falling-over alarm insole, including an insole body, wherein the insole body is further provided with a Bluetooth falling-over alarm device that judges through the human body's movement posture whether the people falls down and gives an alarm. The invention has the beneficial effects as follows: the volume is small, it is convenient to carry, it is integrated and mounted in the insole, it has no any auxiliary feeling, it conforms to the people's wearing habit, whether the human body is fallen down is judged in combination with the integration of information detected by the acceleration sensor, the pressure sensor and the angle sensor, the accuracy of judgment is high and is more than 95%.

Abstract: Provided is a monitor for monitoring the condition of the interior of a living organism from the surface of the living organism. The monitor is provided with: a probe which includes an observation window and is attached to the organism surface; a unit which irradiates, with a laser, at least a portion of an observation region; a unit which detects scattered light resulting from the laser irradiation; a Doppler analysis unit and a SORS analysis unit which narrow down the observation spots to a first observation spot; and a CARS analysis unit which obtains the optical spectrum for at least one component, and outputs first information indicating the condition of the organism interior on the basis of the intensity of the spectrum.

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.