Abstract: Disclosed is an analyte sensing system (1), comprising: a sensor probe (11) for collecting the analyte content in human body and transmitting the collected analyte content information; a transmitter (13) connected to the sensor probe (11) for receiving the analyte content information transmitted by the sensor probe (11) implanted subcutaneously and converting same into a radio signal to output; and a receiver for receiving the radio signal comprising the analyte content information transmitted by the transmitter (13) and converting same into analyte content data to display to the user. The analyte sensing system (1) uses an automatic installer (122) to implant the sensor probe (11) into the human body, and obtains the analyte content information collected by the sensor probe (11) through the transmitter (13) and the receiver. The analyte sensing system (1) has a small structure, and is easy to use and convenient to operate.

Abstract: The present invention comprises medical diagnostic methods and devices that quantify neutrophil populations in blood by using optical spectroscopy, either ex vivo with collected blood or non-invasively in vivo. In certain embodiments, fluorescent and Raman spectroscopy may be used to distinguish and/or quantify the neutrophils from the other blood components. The methods and devices of the invention advance the detection of sepsis by developing a point of care diagnostic device capable of rapid and/or real-time quantification of neutrophils. Other embodiments of the technology are also envisaged, particularly for analysing blood constituents both endogenous and administered.

Abstract: The present invention relates to a device and a method for extracting physiological information indicative of at least one health symptom from remotely detected electromagnetic radiation. The device comprises an interface (20) for receiving a data stream comprising remotely detected image data representing an observed region comprising at least one subject of interest (12), wherein the image data comprises wavelength-dependent image information, wherein the wavelength-dependent image information is composed of at least two color channels (96, 98, 100) representative of respective wavelength portions; an image processor (22) for detecting channel signal strength information for at least two of the at least two color channels (96, 98, 100); and a data comparison unit (24) for comparing detected channel signal strengths with respective reference values.

Abstract: An optical measurement device includes a light source irradiating a test subject with first light L1 for measuring a degree of oxygen supply to a metabolic system and a photodetector receiving reflected light R1 (or transmitted light) of the first light L1 and second light R2 emitted from the test subject according to a degree of oxygen utilization by the metabolic system. In some cases, the light source irradiates a test subject with excitation light L2 such that the second light R2 is generated. The first light is, for example, light of a wavelength range that is attenuated by being partially absorbed into the test subject by passing through the test subject. Specifically, the first light is light of a wavelength range that is attenuated by being partially absorbed into oxidized hemoglobin or reduced hemoglobin contained in the test subject. The second light is, for example, fluorescence emitted from nicotinamide adenine dinucleotide or flavin adenine dinucleotide.

Abstract: A fluorescence observation device includes an oxygen saturation calculation section, a reference region setting section, a region-of-interest setting section, a normalized fluorescence intensity calculation section, and a fluorescent image generation section. The oxygen saturation calculation section calculates the oxygen saturation of the subject for each pixel. The reference region setting section sets a reference region of the subject based on the oxygen saturation. The region-of-interest setting section sets a region of interest of the subject.

Abstract: A microneedle array device includes a substrate and an array of microneedles on the substrate. Each microneedle includes a redox enzyme and redox mediator and an electrically conductive layer on the substrate. The electrically conductive layer may extend partway up each microneedle exposing the tip thereof.

Abstract: The present invention relates to the field of film materials for biosensors, in particular to a film for biosensors and a preparation method. Provided is an organosilicon polymer, the raw materials thereof comprising the following components: at least one active organosilane, at least one curing agent, at least one optional hydrophilic copolymer and at least one optional regulator and/or filling. The membrane prepared from the provided organosilicon polymer has outstanding oxygen permeability and is adjustable in water absorption rate, and can put regulation and restriction on the diffusion of analytes (e.g. glucose) and interferents (e.g. acetaminophen). Meanwhile, the provided organosilicon polymer film also has indispensable physical strength and superior biocompatibility, and can serve as a multifunctional polymer film material for biosensors, such as anti-interference layer, analyte regulating layer and biocompatible layer.

Abstract: A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.

Abstract: A container assembly is disclosed including an outer container, a hollow inner member, and a closure. The outer container has a closed bottom, an open top, and a sidewall extending therebetween. The hollow inner member is disposed within the outer container and has an inner surface defining at least one capillary channel. The inner member includes a first end adjacent to the open top of the outer container and has an outer periphery seated against the sidewall of the outer container. The closure has a proximal end and a distal end. The closure proximal end is seated at least partially within the first end of the inner member to seal the outer container and inner member and define a fluid collection chamber. The closure distal end defines a recessed area shaped to direct fluid under capillary action to the at least one capillary channel in the inner member.

Abstract: In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.

Abstract: A system and method for modeling patient-specific spinal cord stimulation (SCS) is disclosed. The system and method acquire impedance and evoked compound action potential (ECAP) signals from a lead positioned proximate to a spinal cord (SC). The lead includes at least one electrode. The system and method determine a patient-specific anatomical model based on the impedance and ECAP signals, and transform a dorsal column (DC) map template based on a DC boundary of the patient-specific anatomical model. Further, the system and method map the transformed DC map template to the patient-specific anatomical model. The system and method may also include the algorithms to solve extracellular and intracellular domain electrical fields and propagation along neurons. The system and method may also include the user interfaces to collect patient responses and compare with the patient-specific anatomical model as well as using the patient-specific anatomical model for guiding SCS programming.

Abstract: A method and a device for collecting data for posturography comprising a magnetizable body and an acceleration sensor are located on the platform, which magnetizable body and acceleration sensor are connected to a computer by means of an A/D converter. An electromagnet is located under the platform and is attached so as to be displaceable in two axes parallel to the plane of the platform, wherein the electromagnet is connected to an A/D converter and a power supply by means of a circuit, and a time-variable display, which is connected to the A/D converter, and a digital camera which are connected to the computer. By means of the method and the device it is now possible to standardize posturographic measurements, simultaneously detect the acceleration and the position of the platform, and more variably carry out provocations.

Abstract: Embodiments of the present disclosure provide a method for measuring a movement of the cervical vertebra, a device thereof and a wearable apparatus. The method for measuring a movement of the cervical vertebra comprises: obtaining a movement angle of the cervical vertebra with a sensor; and calculating a movement amount of the cervical vertebra based on the movement angle of the cervical vertebra. Therefore, according to embodiments of the present disclosure, exact data values of the movement angles of the cervical vertebra can be acquired with the sensor, and the movement amount of the cervical vertebra can be calculated on the basis of this, thereby a quantitative value of the movement of the cervical vertebra can be acquired exactly in form of a numerical value, which is convenient for future processings.

Abstract: Methods, systems, and apparatuses are disclosed for neuropathic assistance. In one embodiment, a neuropathic assistance system senses and detects at least one of: an inflammation condition, a wound, and a wound-causing environmental factor in an affected tissue, that may cause at least one of: a visual alert, a tactile alert, and an audio alert, to be output in response to a sensing and detection of at least one of: an inflammation condition, a wound, and a wound-causing environmental factor.

Abstract: Disclosed is a method for an electronic device. The method may include: acquiring a galvanic skin response; generating a first parameter for a first interval and a second parameter for a second interval based on the galvanic skin response, the second interval being an interval before the first interval; determining a first threshold corresponding to the first interval based on the second parameter; and determining an activity state of the first interval based on the first threshold and the first parameter corresponding to the first interval.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Abstract: Method and apparatus for performing multiple measurements and diagnoses include a data acquisition module, a data processing module, an optional treatment output module, a user control module, and a user display system, where the data acquisition module sends a plurality of measurement data simultaneously to the data processing module. The data processing module provides a plurality of outputs which can be made available to the user or combined in the diagnostic module. A treatment algorithm in the treatment module can affect the patient through a feedback mechanism. In response, the data processing module generates treatment information needed by the treatment output module. In one embodiment, the data acquisition module sends multiple different measurement data relating to one or more diseases to the data processing module. In response to further measurements of the parameters, an effectiveness of the treatment can be determined and the treatment regimen can be modified, as necessary.

Abstract: Systems and methods for assessing and managing stress of a user is provided. The system includes a wearable device that can be worn by the user; the wearable device include a sensing device for generating at least one time-series signal by continuous sensing of light intensity of light signals. The time-series signal includes at least one continuous photoplethysmographic (PPG) signal having an LF and an HF component. The system also includes a stress assessment device to determine a stress level of the agent based on a processing of the PPG signal. The stress assessment device further includes a feedback device configured by the processor to provide a feedback including at least one remedial message to the agent based on the determined stress level of the agent.

Abstract: A headset for acquiring a bio-signal from a subject, includes a hub; at least 3 flexible branches, each branch having a first end extending from the hub and a second free end, the 3 flexible branches defining an opening formed by the relative position of the free ends; and at least 3 electrodes, wherein at least one electrode is located on each of the 3 flexible branches, the electrodes being configured for acquiring a bio-signal; the 3 flexible branches having a collapsed state; and an expanded state wherein the 3 electrodes are in contact with the scalp of the subject; and the headset is expanded from its collapsed state to its expanded state by placing the free ends on the top of the subject's head, and progressively lowering and sliding the same while contacting the scalp until the hub is contacted with the top of the head of the subject.

Abstract: An eyeglass-type electroencephalogram interface system is worn on the head of a user. The system includes: an output section for presenting a visual stimulation to the user; an ear electrode portion disposed at a position coming in contact with an ear of the user when the system is worn; a facial electrode portion disposed at a position coming in contact with the face below a straight line connecting an external canthus and an internal canthus of an eye of the user, such that the mass of the system is supported at the position, when the system is worn; and an electroencephalogram measurement and determination section for measuring an event-related potential on the basis of a potential difference between the ear electrode portion and the facial electrode portion based on the visual stimulation being presented by the output section as a starting point.

Abstract: Embodiments of the present disclosure provide techniques and configurations for a wearable sensor apparatus. In one instance, the apparatus may comprise a first flexible substrate, including a first plurality of sensors disposed on a first side of the first flexible substrate to be in direct contact with a user's body, and a first set of conductive connectors disposed on a second side of the first flexible substrate; and a second flexible substrate that includes a second set of conductive connectors disposed on a first side of the second flexible substrate compatibly to the first set of conductive connectors to mechanically and electrically couple the second flexible substrate with the first flexible substrate, and circuitry disposed on a second side of the second flexible substrate to receive and process readings provided by the sensors via the first and second sets of conductive connectors. Other embodiments may be described and/or claimed.

Abstract: A system and method that will serve for measuring the sleep of at least one user. The system will provide the measurement by communicating sleep parameters of at least one user to a mobile third party client application 170 from a sensor device 120. The mobile third party client application 170 is capable to automatically deduce the starting time of sleep without the user indicating the start of sleep. The system is configured to measure the sleep of more than one user by detecting the presence of more than one user in the bed using a matrix of sensors 710.

Abstract: Embodiments of the present disclosure provide techniques and configurations for an apparatus for opportunistic measurements of user's physiological context. In one instance, the apparatus may comprise a work surface that includes one or more electrodes disposed on the work surface to directly or indirectly contact with user's portions of limbs, when the user's portions of limbs are disposed on the work surface to interact with the apparatus, to obtain one or more parameters of user's physiological context; and circuitry coupled with the electrodes to detect direct or indirect contact between the user's portions of limbs and the electrodes and on detection, collect the parameters of the user's physiological context while the direct or indirect contact is maintained. Other embodiments may be described and/or claimed.

Abstract: Embodiments of the present disclosure provide techniques and configurations for an apparatus for opportunistic measurements and processing of user's context. In one instance, the apparatus may include a sensor module with sensors disposed on a work surface to maintain direct or indirect contact with portions of user's limbs for a time period when the portions of user's limbs are disposed on the work surface, to obtain readings of first and second parameters of user's context over the time period of the direct or indirect contact; and a processing module to process the readings of the first and second parameters, including to identify a first feature of the first parameter and a second feature of the second parameter that is temporally correlated with the first feature, and determine a third parameter of the user's context based on the identified first and second features. Other embodiments may be described and/or claimed.

Abstract: A computer-implemented method for biological signal recording, including modulating a sampled evoked biological signal with a carrier sequence code resulting in a modulated evoked biological signal. The carrier sequence code has an autocorrelation function. The method includes demodulating the modulated evoked biological signal by calculating a convolution of the modulated evoked biological signal with the carrier sequence code resulting in an evoked biological signal spectrum. The evoked biological signal spectrum has a peak to sideband ratio as a function of the carrier sequence code. The method includes calculating deviations between each element of the sampled evoked biological signal and the peak to sideband ratio and filtering noise artifacts from the sampled evoked biological signal based on the deviations. Peak to sideband ratios may also be optimized by varying the sampling rate.

Abstract: According to one embodiment, an electronic device is configured to be worn by a user. The electronic device includes a sensor, a wireless transceiver, and a processor. The sensor measures vital data of the user. The wireless transceiver performs wireless communication with an external device. The processor selects a storage method of the vital data corresponding to strength of a signal transmitted from the external device and received by the wireless transceiver.

Abstract: Devices, systems, and methods automatically detecting anomalous waveforms and eliminating these waveforms from physiologic measurements are disclosed. For example, in some instances a method includes collecting a pressure data from an intravascular device positioned within the vessel of the patient, the pressure data including a pressure waveform for each cardiac cycle of the patient; comparing the pressure waveform for each cardiac cycle of the patient to a reference pressure waveform to identify an anomalous pressure waveform; and calculating a pressure ratio utilizing the pressure data from the intravascular device, wherein data from the anomalous pressure waveform is excluded from the calculation.

Abstract: A method and apparatus is disclosed herein for erythema grading for psoriasis. In one embodiment, the method comprises generating Skellam distribution statistics related to differences between readout voltages for one or more psoriasis regions for a patient and a normal skin region for the patient; and generating an erythema grading classification for erythema regions in psoriasis using the Skellam distribution statistics as feature vectors.

Abstract: Devices, systems, and methods of mapping a vessel system of a patient and identifying lesions therein are disclosed. This includes a method of evaluating a vessel of a patient, the method comprising obtaining image data for the vessel of the patient, obtaining physiological measurements for the vessel of the patient, co-registering the obtained physiological measurements with the obtained image data such that the physiological measurements are associated with corresponding portions of the vessel of the patient, analyzing the co-registered physiology measurements to determine a classification of a lesion within the vessel of the patient, and outputting, to a user interface, the classification of the lesion. Other associated methods, systems, and devices are also provided herein.

Abstract: A biological sensing system includes a biological information detector that is placed in a first specified portion of a living thing, and detects biological information of the living thing; a position displacement detector that detects an amount of a displacement of a position of the biological information detector from the first portion when the biological information is detected; and a processor that executes a process including estimating optimum biological information from the biological information detected by the biological information detector in accordance with the amount of the displacement.

Abstract: Doctor and patient communication is improved by electronically transmitting a series of questions to a computing device of the patient, and electronically receiving answers to the questions provided by the patient. A computer server analyzes the answers to the questions to determine if a state of health of the patient is serious and requires the immediate attention of the doctor. If the software determines the state of health to be serious, the server transmits an alert to a computing device of the doctor. The alert can include a series of lights, for example in the form of a traffic light, to quickly convey to the doctor the state of health of the patient.

Abstract: A system includes at least one medical device configured to generate a plurality of messages and a control unit in the at least one device. The control unit is configured to generate an auditory signal corresponding to one of the plurality of messages, wherein the auditory signal is configured based on a functional relationship linking psychological sound perceptions in a clinical environment to acoustic and musical sound properties. The functional relationship includes a plurality of types of auditory messages defining seven unique categories.

Abstract: A tomographic imaging system includes a source configured to irradiate an object; a first image sensor including a first semiconductor substrate having a first face upon which a monolithic first pixel array is located; and a gantry configured to hold the first image sensor and rotate the image sensor around the object about a first rotation axis, the first pixel array including a first plurality of pixels configured to receive light that travels through or from the object based on the irradiation, the first plurality of pixels of the first pixel array being arranged in one or more rows and a plurality of columns such that, a total number of the one or more rows is less than a total number of the plurality of columns, and the one or more rows extend in a first direction, the first image sensor being arranged such that an angle between the first direction and a second direction is greater than 45 degrees and equal to or less than 90 degrees, the second direction being a direction parallel to the rotation axis o

Abstract: A system and method for adjusting the height of a portion of a patient support table to accommodate various types of patients is disclosed. The patient support table includes a center section that is movable relative to first and second sections located on opposite sides of the center section. A lift mechanism is mounted to the support table to raise and lower the center section relative to the stationary first and second sections. When the center section is in its fully raised position, the patient support platform can be moved into and out of the medical scanning device by a platform drive mechanism. The lift mechanism is contained within the patient support table. The platform drive mechanism can be mounted either on the patient support table or on the medical scanning device, depending upon whether the patient support table is stationary or movable.

Abstract: A device (1) for placing the joint of the knee of a person in contraction with a view to performing an examination of the said knee. The device comprises: a structure (2) adapted to receive the person in a seated or recumbent position, locking means (4) for locking a corresponding thigh of the person with respect to the structure, and a toe-clip (5D, 5G), adapted to receive a corresponding foot of the person, the said toe-clip comprising means for locking the foot of the person and being rotatable about an axis (RD, RG) adapted to be placed perpendicular to the foot of the person.

Abstract: An x-ray/gamma ray imaging apparatus includes a pixilated x-ray/gamma ray detector (3) including a member configured to detect incident x-ray/gamma ray wavelength photons, a position for a body under test (2), an x-ray or gamma ray source (1), and a structure configured to perturb the energy spectrum (6), each lying on a common axis. The source is arranged to direct an x-ray gamma ray energy spectrum along the common axis to impinge upon a structure configured to perturb the x-ray energy spectrum and a positioned body/object under test. The structure and the position for the body under test lie between the source and the detector member, and the structure includes at least three adjacent regions, each region different to immediately adjacent regions and configured to perturb the x-ray energy spectrum differently. Detected photons are subject to a random noise reduction algorithm.

Abstract: An imaging system (100) includes a detector array (110) that detects radiation traversing an examination region. The detector array includes at least a set of non-spectral detectors (112) that detects a first sub-portion of the radiation traversing the examination region and generates first signals indicative thereof. The detector array further includes at least a set of spectral detectors (114) that detects a second sub-portion of the radiation traversing the examination region and generates second signals indicative thereof. The imaging system further includes a reconstructor (120) that processes the first and second signals, generating volumetric image data.

Abstract: The invention relates to a method for capturing a three-dimensional x-ray image (1) of an object (2) by means of an x-ray system (3) comprising an x-ray source (4), an x-ray detector (5) and a shutter matrix (7), the shutter matrix (7) having a plurality of shutter elements (18), the x-ray absorption properties of which are controllable. In the first method step, at least one region (21) to be captured of the object (2) is defined, wherein settings are planned for the individual shutter elements (18) of the shutter matrix (7) for different rotary positions (14, 15, 16, 17), taking into account the defined area (21) to be captured. Then, a plurality of two-dimensional x-ray images is captured from the planned rotary positions (14, 15, 16, 17) during at least one partial rotation (9) using the planned settings of the shutter elements (18), wherein the overall three-dimensional x-ray image (1) of the area (21) to be captured is generated from the individual two-dimensional x-ray images.

Abstract: A radiation imaging system includes: multiple radiation imaging apparatuses each including a radiation detecting panel and an enclosure enveloping the radiation detecting panel. The multiple radiation imaging apparatuses are arrayed so that a part of each of the radiation imaging apparatuses spatially overlap as seen from a radiation irradiation side, and a radiation image is acquired based on image signals from each of the multiple radiation imaging apparatuses. The enclosure of at least one radiation imaging apparatus of the multiple radiation imaging apparatuses is formed so that a radiation transmittance of the enclosure which defines the overlapping region is higher than a radiation transmittance of the enclosure which defines a different region.

Abstract: Devices, systems, and methods of evaluating a vascular system of a patient, are provided. In some instances, the method includes obtaining external imaging data associated with the heart; obtaining cardiac test data associated with the heart; generating a three-dimensional graphical representation of the heart using the external imaging data and the cardiac test data; and outputting the graphical representation of the heart to a display device, wherein the graphical representation of the heart includes a graphical representation of the cardiac test data. Corresponding systems and devices are also provided.

Abstract: A computed tomographic (CT) apparatus and for a method of controlling the same are provided. The CT apparatus includes an X-ray scanner configured to divide X-rays penetrating a subject by energy bands, and capture scout images of the respective energy bands. The CT apparatus further includes an image processor configured to generate substance images of substances of the subject, based on the scout images, and a display configured to display a substance image of the substance images. The CT apparatus further includes an input interface configured to receive a scanning region for the displayed substance image.

Abstract: The invention relates to systems and methods for diagnosing strokes. In particular, systems and methods for acquiring timely patient status information are described that enable a physician to make diagnostic and treatment decisions relating to ischemic and hemorrhagic strokes. The systems and methods enable the efficient and quantitative assessment of arterial collaterals within the brain for aiding these decisions in the case of ischemic strokes. In the case of hemorrhagic strokes, the systems and methods are effective in determining if there is a leak and what is the rate of leaking. The systems and methods of the invention can be used to improve the accuracy and confidence of ASPECTS.

Abstract: A breast tomography system includes an X-ray generation tube including a reflection type target, an X-ray detector facing the X-ray generation tube with an imaginary rotation axis placed therebetween, and a gantry that stores the X-ray generation tube and the X-ray detector and that includes a front panel on the subjectee side. A tube axis of the X-ray generation tube is disposed to extend along the front panel.

Abstract: Devices, systems, and methods of evaluating risk associated with a condition of the vessel and providing an objective intervention recommendation based on the evaluated risk are disclosed. The method includes steps of obtaining physiologic measurements from a first instrument and a second instrument positioned within the vessel of the patient while the second instrument is moved longitudinally through the vessel from a first position to a second position, obtaining image data from an image of a vessel system, co-registering the physiologic measurements with the image data to produce co-registered physiologic measurements, and determining whether to perform a first surgical procedure or a second surgical procedure, wherein the determining is based on the co-registered physiologic measurements. Other associated methods, systems, and devices are also provided herein.

Abstract: Devices, systems, and methods for identifying and presenting cardiac treatment options, for assessing the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel, by obtaining an image of the vessel, obtaining pressure measurements from the vessel, generating a diagnostic visualization image, identifying a treatment option, and generating a predictive visualization image. The various images and options are displayed on a medical personnel display and a patient display.

Abstract: Data of a predetermined volume portion of an object under examination is captured by an x-ray system that includes an x-ray source and a detector. The x-ray source is activated to generate x-rays that emerge from the x-ray source, radiate through the volume portion, and after radiating through, impinge on the detector. X-rays impinging on the detector are captured pixel by pixel, in order to capture the data of the predetermined volume portion. With the pixel-by-pixel capture, only a subset of all the pixels of the detector is evaluated.

Abstract: The embodiments relate to a method and device for determining plaque deposits in coronary arteries. According to the method, a coronary angiography radiography image of a subject is obtained using an imaging modality. The obtained radiography image is calibrated for further analysis of the radiography image. Image processing techniques such as thresholding and histogram equalization are applied on the radiography image to extract vessel tree structure for analysis. Further, an inner lumen width and an outer vessel width are computed based on the processed radiography image. Further, a level of plaque deposition is determined based on the inner lumen and outer vessel dimensions. Further, the result based on the analysis is displayed to the user. The result includes the level of plaque deposits within the lumen on the vascular structure and possible risks posed by the plaque deposits to a subject.

Abstract: An X-ray imaging apparatus can include an X-ray detector configured to acquire X-ray data by detecting X-rays and an image processor configured to segment a first image generated based on the acquired X-ray data into two or more segmentation regions, to identify one or more materials present in one segmentation region of the two or more segmentation regions, and to acquire an image relating to an object which includes abnormal materials.

Abstract: Devices, systems, and methods of evaluating risk associated with a condition of the vessel and issuing an automatic recommendation based on co-registered physiological measurements are disclosed. The includes steps of obtaining image data for the vessel of the patient, obtaining physiological measurements for the vessel of the patient, co-registering the obtained physiological measurements with the obtained image data such that the physiological measurements are associated with corresponding portions of the vessel of the patient, analyzing the co-registered physiology measurements to identify a region of interest, and outputting, to a user interface, a suggested diagnostic procedure for the region of interest based on the analysis of the co-registered physiology measurements.

Abstract: Devices, systems, and methods for evaluating patient vasculature are provided. In some instances, the methods can include obtaining external imaging data associated with at least one of a vessel and a heart; obtaining physiology data associated with the vessel; obtaining intravascular imaging data associated with the vessel; co-registering the physiology data and the intravascular imaging data with the external imaging data; generating a three-dimensional graphical representation of the at least one of the vessel and the heart based on the external imaging data, the physiology data, and the intravascular imaging data; and outputting the graphical representation of the at least one of the vessel and the heart to a display device, wherein the graphical representation includes a first indicator associated with a location within the vessel of the co-registered physiology data and a second indicator associated with a location within the vessel of the co-registered intravascular imaging data.