Abstract: An ultrasound observation apparatus includes: an analysis unit that analyzes a frequency of a signal using a parameter that differs depending on presence or absence of a contrast agent in a specimen to calculate a frequency spectrum, the signal being generated based on an echo signal reflected from the specimen; a calculation unit configured to calculate a feature of the frequency spectrum; a generating unit that generates feature image data for displaying visual information related to the feature in a display pattern that differs depending on the presence or absence of the contrast agent in the specimen; a determination unit that determines the presence or absence of the contrast agent using the frequency spectrum and information on a known frequency spectrum in the presence of the contrast agent in the specimen; and a control unit that changes a setting of the parameter in accordance with a result of the determination.

Abstract: A storage container to receive and store a biopsy sample of an organism, held by a biopsy sample collector, the storage container comprising a container body defining a containment region with an open end, and a container cap removably located at the open end to seal the containment region, the cap including a passage that is closed by a closure that is able to be ruptured to allow a biopsy sample retaining biopsy sample collector to thereat enter the containment region so that the sample can be stored in the containment region and the sample collector can seal the passage.

Abstract: Disclosed are kits for at least partly liquefying tissue. The kit may include a liquefaction promoting medium (LPM). The LPM may include a non-ionic surfactant; a zwitterionic surfactant; and an abrasive material. The kit may include instructions. The instructions may direct a user to treat a tissue of a living subject by: applying the LPM together with the abrasive material to the tissue of the living subject; and transmitting energy to the tissue of the living subject through the abrasive material in the presence of the LPM effective to cause at least partial dissolution of one or more components of the tissue of the living subject.

Abstract: Tissue plugs for occlusion of hollow anatomical structures and methods for their use are provided.

Abstract: A retractor for implanting a paddle lead of an electrical stimulation system includes a shaft defining a length, an interior lumen, a first end for receiving tools or paddle lead, and a second end opposite the first end and configured and arranged for insertion into tissue of a patient; a handle coupled to the shaft; and at least one divider disposed within the interior lumen and dividing a portion of the interior lumen into at least two compartments, wherein the at least one divider extends from at or near the first end of the shaft and no more than 70% of the length of the shaft. At least one of the compartments is sized for implantation of a paddle lead of an electrical stimulation system therethrough.

Abstract: An ophthalmic tool includes an ophthalmic speculum for holding a patient's eye open and for guiding a lens probe of an eye imaging device to be directly contacted with a cornea of the patient's eye. The ophthalmic speculum includes two eyelid distensible frames, a mechanism to spread the eyelid distensible frames apart, and a probe guiding frame including a plurality of probe guiders spacedly extended from the eyelid distensible frames. Each probe guider has a peak upwardly extended above the eyelid distensible frame that serves as a guiding point and forms a probe guiding cavity within the guiding points of the probe guiders. The lens probe is guided to be disposed within the probe guiding cavity via the guiding points before and after the lens probe is aligned and contacted with the cornea of the patient's eye in a proper upright orientation.

Abstract: Methods and constructs for soft tissue to bone repairs employing tensionable knotless anchors, without knot tying. The tensionable knotless anchors may be used by themselves or in combination with additional constructs (which may have a similar or different configuration, i.e., modified according to the specific repair) and with the flexible strands provided through tissue, around tissue, or through and around tissue to be repaired or fixated.

Abstract: The present disclosure relates to an anchor assembly. The anchor assembly includes an anchor defining a cavity and an opening to the cavity and an insertion member configured for arrangement within the anchor cavity. The insertion member may include a body having a proximal end portion and a flat distal end portion. A method of tissue repair and other anchor assemblies are also disclosed.

Abstract: The present disclosure relates to an anchor assembly. The anchor assembly includes an anchor defining a cavity and an opening to the cavity and an insertion member configured for arrangement within the anchor cavity. Other anchor assemblies, anchors, and delivery devices are also disclosed.

Abstract: The present disclosure relates to a suture anchor. The suture anchor includes a body having a proximal end and a distal end, the body including threads along at least a partial length of the body and at least one through hole, the threads including a profile such that the threads located near the distal end of the body include a first shape and the threads located near the proximal end of the body include a second shape different from the first shape. Delivery devices and anchor dilators are also disclosed.

Abstract: A device for supporting an endoscopic tool is disclosed comprising attachment means for attaching the device to an endoscope, a first guide tube having a distal open end and configured for accepting the endoscopic tool through it, first and second projecting members extending distally of the attachment means and being spaced apart when the device is attached to the endoscope to define a working space between them. The attachment means comprise first and second clamping members and at least one cable linking the clamping members. The cable is remotely actuatable for moving the clamping members relative to each other to adjust a spacing between them, accepting an endoscope. The cable allows for securing the clamping members to the endoscope. The first projecting member is attached to the first clamping member such that it has a fixed or at least one fixable position relative to the first clamping member, and the second projecting member is attached to the second clamping member.

Abstract: In a general aspect, a medical device includes a receiving arm configured to be coupled to at least a portion of an implant, and a clamping arm having a proximal end coupled to the receiving arm and having a track at a distal end of the clamping arm. The medical device also includes a sliding component including a needle and configured to slidably move along the track of the clamping arm.

Abstract: An electromechanical handheld surgical device includes a housing, and a non-planar display screen. The housing encloses a processor, a memory storing instructions, and an orientation detector configured to detect orientation of the electromechanical handheld surgical device with respect to a reference direction. The non-planar display screen is fixedly attached around a portion of the housing and configured to display information. Then instructions, when executed by the processor, cause the non-planar display screen to display the information on a portion of the non-planar display screen. The portion of the non-planar display screen is determined by the processor based on the detected orientation.

Abstract: A surgical severing and stapling instrument, suitable for laparoscopic and endoscopic clinical procedures, clamps tissue within an end effector of an elongate channel pivotally opposed by an anvil. Various embodiments are configured to be operably attached to a robotic system to receive actuation/control motions therefrom.

Abstract: A surgical stapling device that comprises an end effector. According to various embodiments, the end effector comprises a circular anvil having a staple forming surface and a plurality of staples facing the staple forming surface of the anvil. The end effector also comprises a staple driver assembly comprising a plurality of staple drivers. Each staple driver supports one of the plurality of staples and is configured such that, when the staple driver assembly is actuated, each staple driver drives the staple into the staple forming surface of the anvil. A first quantity of the plurality of staple drivers has a first height and a second quantity of the plurality of staple drivers has a second height, wherein the first height is less than the second height.

Abstract: A staple cartridge for use with a stapling device that has an actuator that is selectively actuatable in an axial direction and an anvil portion that is selectively movable between open and closed positions is disclosed. Various embodiments of the present invention include a cartridge body that movably supports first and second staple drivers. The staple drivers each support a staple thereon and serve to drive the staples into forming contact with the anvil upon actuation by the actuator. The various embodiments of the present invention enable the final formed heights of the staples to be varied so as to apply various clamping forces and pressures to soft tissue captured within the staples. In at least one embodiment, the staples can include crowns formed thereon which can be utilized to adjust or control the clamping force and/or pressure applied by the staples.

Abstract: A staple cartridge for use with a stapling device that has an actuator that is selectively actuatable in an axial direction and an anvil portion that is selectively movable between open and closed positions is disclosed. Various embodiments of the present invention include a cartridge body that movably supports first and second staple drivers. The staple drivers each support a staple thereon and serve to drive the staples into forming contact with the anvil upon actuation by the actuator. The various embodiments of the present invention enable the final formed heights of the staples to be varied so as to apply various clamping forces and pressures to soft tissue captured within the staples. In at least one embodiment, the staples can include crowns formed thereon which can be utilized to adjust or control the clamping force and/or pressure applied by the staples.

Abstract: Devices, tools, systems, kits and methods for closing a tissue opening non-invasively are presented. The devices include a tissue closure device that reliably induces eversion of tissue edges that define a tissue opening. The devices may be used in combination with an applicator tool to provide easy and uniform apposition of the tissue closure devices across the tissue opening. Further embodiments provide for releasable locking of the tissue closure devices, allowing for drainage of wound edema and/or treatment of infection, without removal and reapplication of the devices. Still further embodiments allow for the passing of moisture or other substances that may collect under a tissue closure device.

Abstract: A surgical severing and stapling instrument, suitable for laparoscopic and endoscopic clinical procedures, clamps tissue within an end effector of an elongate channel pivotally opposed by an anvil. Various embodiments are configured to be operably attached to a robotic system to receive actuation/control motions therefrom.

Abstract: The present invention includes a surgical stapler having a staple cartridge, an anvil, a cutting member having a cutting surface, and a driver operably engaged with the cutting member to move the cutting member relative to the anvil and the staple cartridge. In at least one embodiment, one of the anvil and the staple cartridge defines a slot which is configured to receive at least a portion of the cutting member and guide the cutting member as it is moved relative to the anvil and the staple cartridge. In these embodiments, the slot can also be configured to receive a portion of the driver operably engaged with cutting member and support the driver when it moves the cutting member. In at least one embodiment, the slot is defined by at least one radius of curvature.

Abstract: Systems and methods for creating an arteriovenous (AV) fistula comprise an elongate member, a distal member connected to the elongate member and movable relative to the elongate member, and a heating member disposed on at least one of the movable distal member and the elongate member. The distal member comprises structure for capturing tissue to be cut to create the fistula, and the heating member is adapted to cut through the tissue to create the fistula. The elongate member comprises an elongate outer tube. A shaft connects the distal member to the elongate member, and is extendable and retractable to extend and retract the distal member relative to the elongate member.

Abstract: A circular stapler apparatus for stapling tissue includes a staple and pledget assembly and a circular staple head operable to drive staples toward an anvil. A staple of the staple and pledget assembly has a pair of legs disposed substantially perpendicular to a crown of the staple in a first position. The pair of legs is operable to advance against a pocket in the anvil to form a staple with bent legs. The staple and pledget assembly includes the staple and a pledget configured to receive the pair of legs of the staple. The pledget comprises a bioabsorbable material. The pledget is configured to advance distal ends of the pair of legs to a position in which the distal ends are laterally offset from a plane in which the crown of the staple is disposed.

Abstract: A novel catheter-based system which ligates the left atrial appendage (LAA) on the outside of the heart, preferably using a combination of catheters and/or instruments, e.g., a guide catheter positioned inside the left atrial appendage which may assist in locating the left atrial appendage and/or assist in the optimal placement of a ligature on the outside of the appendage, and a ligating catheter and/or instrument outside the heart in the pericardial space to set a ligating element at the neck of the left atrial appendage.

Abstract: The present disclosure provides occlusion devices which comprise (a) a self-expanding support frame having a longitudinal axis comprising a plurality of loops each having an orifice, the support frame being self-expandable from a constrained shape to an unconstrained shape, and (b) a covering material covering an orifice of at least one of the loops. Also provided are assemblies and kits that contain such occlusion devices, and methods of delivering such occlusion devices to a patient.

Abstract: Instruments and surgical techniques may be used to correct a bone deformity, such as a bunion in which a metatarsal is misaligned with respect to a medial cuneiform. In some examples, a bone cutting guide is utilized to cut an end of the metatarsal and/or an end of the medial cuneiform to facilitate realignment of the bones. The cutting guide can have a pivotable cut guide surface along which a cutting instrument is translated to provide a precise bone cut. In some applications, after suitably preparing and aligning the bones, the bones are compressed together using a fixation pin. The fixation pin can be driven through one of the bones, into the second bone, and then further driven to compress the bones together.

Abstract: A rotary mill (2) comprising a body portion (4) having a milling surface (10) for milling a first bone, a guide portion (6) having a guide body (22), and inter-engageable guide formations (20, 24) formed on the body portion (4) and guide portion (6), the guide body (22) having a projection (7) which is adapted to hold a second bone (11) away from the rotary mill during the milling operation.

Abstract: When processing bone tissue, the work site is often out of alignment with the insertion path of a tool device. A tool device (1) is provided with an endoscope (2), through the working channel (2.1) of which a guiding part (3) and a tool part (5) guided in this can be moved with their distal ends to a distal working area. The tool part (5) has a tool shaft (5.1) with a rotating tool (5.3). In the tool device there is a secure connection between the endoscope and the guiding part, during the task, and, this connection can be established in a simple manner prior to the beginning of the task and it can also be released again in a simple manner after the task ends. The guiding part (3) is able to be connected rigidly with the endoscope (2) axially.

Abstract: A device (10) for use in orthopaedic surgery includes a metallic central member (30). The device also includes an outer portion (20) comprising a polymer, which can be moulded around the metallic central member. The outer portion thus surrounds the metallic central member. The outer portion has a profiled outer surface (40), such as teeth, ribs or ridges for removing bone. Engagement features for resisting relative movement between the metallic central member and the outer portion can comprise ridges, grooves (34, 36) and apertures (32) of the metallic central member, filled with polymer. The device can be a broach or rasp. A surgical instrument kit includes a plurality of differently sized devices of the kind described herein.

Abstract: A surgical instrument includes an actuator. A member is connected with the actuator and includes a mating part releasably engageable with a tissue engaging element such that the member is interchangeable with a plurality of alternate tissue engaging elements. Systems, implants and methods are described.

Abstract: A drill guide for drilling bone comprising a housing having a bore running through the housing is disclosed. In one embodiment, the drill guide may comprise a locking member coupled to the housing that is adapted to engage with a locking portion of a drill bit to lock the drill bit axially within the housing. The locking member may also be adapted to disengage with the drill bit to allow the drill bit to move within the bore of the housing and be inserted into bone. A movable guide may also be provided with the drill guide, such movable guide including a bore for receiving a portion of the drill bit and allowing the same to move axially within the housing. Methods of using the aforementioned drill guide are also disclosed.

Abstract: A system for replacing a trochlear groove region of a femur. The system includes a prosthesis that includes a bone contact surface and a periphery that defines an outer perimeter. The bone contact surface has a plurality of protrusions and a spatial configuration with respect to one another. Additionally, the system includes a first template that has a plurality of guide holes and a first periphery that defines an outer perimeter that substantially corresponds with the periphery of the prosthesis. Also, included in the system is a second template that has a plurality of guide holes and a second periphery that defines an outer perimeter that substantially corresponds with the periphery of the prosthesis. The plurality of guide holes of the second template are spatially arranged with respect to the second periphery to substantially match the spatial configuration of the plurality of protrusions of the prosthesis.

Abstract: A medical positioning bracket is described that provides users with the ability to attach and secure multiple bone tunnel drill guides into a single working unit. Users can manipulate each drill guide independently and lock the drill guides at desired locations relative to one another to achieve precise bone tunnel angles and locations.

Abstract: The present invention provides devices and methods for percutaneously retrieving an embolized or malpositioned heart valve or foreign bodies from a patient's body. Several of these devices may include a catheter system with expandable and retractable baskets attached to a catheter and guidewire system. The guidewire may be inserted through the lumen of the embolized or malpositioned heart valve, capturing the valve in the baskets, and deploying a mechanism to crush the valve within the baskets. Then the crushed baskets and valve may be retrieved either from the body or to a safer location such as but not limited to the descending aorta. This system is advantageous because it does not require open surgery to retrieve the valve or embolized material.

Abstract: Basket type grasping forceps include a sheath, a main body section, and a manipulation section, the main body section includes a basket section and a manipulation wire, the basket section includes a plurality of basket wires and a distal fixing member fixed to the plurality of basket wires, and the distal fixing member has a wire-fixing section to which a first wire serving which is at least one of the plurality of basket wires is fixed, and a high-strength fixing section to which a second wire which is at least another one of the plurality of basket wires is fixed more strongly than a fixing strength of the first wire in the wire-fixing section.

Abstract: An apparatus includes a generator including a control module that is operably coupled to a power module. The power module is configured to produce an electronic signal to be received by an ultrasonic energy delivery assembly. The ultrasonic energy delivery assembly is characterized by a natural frequency, and the electronic signal is characterized by a frequency. The control module is configured to send a control signal to the power module to randomly vary the frequency of the electronic signal within a range defined at least in part by the natural frequency.

Abstract: A surgical instrument which comprises a first and a second working sections 11a, 11b. The working sections comprises a first and a second gripping surface 15a, 15b at the end portions. The first and the second gripping surface 15a, 15b comprise flat peripheral areas 19a, 19b and a plurality of protrusions 21a, 23a, 12b, 23b inside the flat peripheral areas 19a, 19b.

Abstract: A treatment instrument apparatus, which is an endoscopic treatment instrument, includes a sheath having an opening in a distal end; an actuator placed in the sheath and driven by a gas supplied via a tube; a treatment unit connected with the actuator by a wire and placed on a distal end side of the opening of the sheath; and an opening and closing switch, which is an operation portion used for an operation of supplying the gas into the sheath and supplying the gas to the actuator.

Abstract: A surgical device includes a handle body extending along a handle axis. The handle body is releasably engaged to a tunneling shaft extending along a shaft axis transverse to the handle axis. At least one tool is mounted to the handle body. Each tool includes a working end adapted to actuate an element of an implantable device.

Abstract: A device and method for intravascular dissection of a body lumen, and particularly a blood vessel wall, is disclosed herein. One aspect of the present technology, for example, is directed toward a tubular elongated member having a lumen therethrough, wherein the elongated member includes a distal region configured to be positioned within a blood vessel wall. The distal region can include an angled distal face having a distal-most edge configured to puncture the vessel wall and a proximal-most edge. The member can include an exit port fluidly coupled to the lumen, and positioned along the distal face between the distal-most edge and the proximal-most edge. A central longitudinal axis of the exit port can he offset from a central longitudinal axis of the elongated member such that the exit port is closer to the distal-most edge than the proximal-most edge.

Abstract: The invention is directed to methods and apparatus for centering a microcatheter within a vasculature. In one aspect, the methods and apparatus can be used to support centering and to facilitate a guidewire to cross through a chronic total occlusion. In one embodiment, the catheter apparatus includes: a microcatheter having a lumen, a distal opening and a distal end; one or more guidewires for passing through the lumen of the microcatheter; an inner shaft having a lumen, a distal opening and a distal end for passing the inner shaft over the microcatheter; an outer shaft having a lumen, a distal opening and a distal end for passing the outer shaft over the inner shaft; and a self-expandable scaffold structure disposed towards the distal end of the inner shaft. The self-expandable scaffold structure is preferably non-occluding thereby allowing blood to flow through the scaffold. Preferably, the inner shaft and microcatheter are capable of being independently operable.

Abstract: A surgical knife is provided. The knife has a blade, a handle, an elongated tube connected to the blade and the handle, and a sheath slidable over the tube and blade. The sheath is moveable from a first position that exposes the blade to and second position that conceals the blade. The blade, handle, and tube are in a fixed rigid relationship with each other while the sheath is movable.

Abstract: A minimally invasive tissue incision system for creating joint capsulotomies and releasing/incising various tendon and fibrous band structures. The system contains a penetrating needle which is retractable so as to expose a cutting element, and which may be used as a penetrating needle to pierce the skin and other soft tissue structures. The cutting element provided within the penetrating needle may be used to incise subsequent tissue structures after the initial penetration. The system facilitates such procedures by providing the cutting element with the confines of the needle which provides safe introduction of the cutting element directly to the site via the needle.

Abstract: A treatment device includes a probe having a treatment portion to treat a biological tissue by using the ultrasonic vibration generated in an ultrasonic transducer; an action portion being able to be close to and away from the treatment portion and including a pressing portion that presses the biological tissue to the treatment portion; and a vibration damping portion disposed in a part of the pressing portion in a state of facing the treatment portion, moving following the treatment portion to which the ultrasonic vibration is transmitted when abutting on the treatment portion in a state where the ultrasonic vibration is transmitted to the treatment portion, and prevented from being grinded by the treatment portion to which the ultrasonic vibration is transmitted.

Abstract: A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal region and a distal region and being rotatable by a motor. The distal region has a smaller diameter than the proximal region. A cable is coupled to the distal region of the core and extends distally thereof. A torque tube is positioned over the cable and a coil is positioned over a distal portion of the cable. A distal portion of the cable has a non-linear configuration. A first covering material is positioned over the coil.

Abstract: Described here are devices and methods for performing atherectomies. Generally, the atherectomy devices may comprise a handle, a cutter assembly, and a catheter or catheter assembly therebetween. The cutter assembly may include a cutter housing and a cutter comprising a first cutting element and a second cutting element, each of which may be rotated relative to the atherectomy device to cut occlusive material.

Abstract: A device and method is provided to gain access to interior body regions. The system includes a safety needle assembly, a blade assembly, an obturator assembly, and a dilator assembly. The safety needle assembly accesses an interior body region, after which the blade assembly expands the pathway created by the safety needle assembly. The obturator then further expands the pathway and delivers the dilator assembly to the desired location. The safety needle assembly, obturator assembly, and blade assembly are removed, leaving the dilator assembly in place for future procedures.

Abstract: A device and method is provided to gain access to interior body regions. The system includes a safety needle assembly, a blade assembly, an obturator assembly, and a dilator assembly. The safety needle assembly accesses an interior body region, after which the blade assembly expands the pathway created by the safety needle assembly. The obturator then further expands the pathway and delivers the dilator assembly to the desired location. The safety needle assembly, obturator assembly, and blade assembly are removed, leaving the dilator assembly in place for future procedures.

Abstract: A device and method is provided to gain access to interior body regions. The system includes a stylet needle assembly, a safety needle assembly, a blade assembly, a retractable obturator assembly, and a dilator assembly. The safety needle assembly accesses an interior body region, after which the blade assembly expands the pathway created by the safety needle assembly. The obturator then further expands the pathway and delivers the dilator assembly to the desired location. The safety needle assembly, obturator assembly, and blade assembly are removed, leaving the dilator assembly in place for future procedures.

Abstract: An instrument access device 1 comprises a proximal member 25 for location externally of an opening into a body cavity. A first connector 20 extends between the proximal member 25 and a first instrument receiver 2. A second connector 21 extends between the proximal member and a second instrument receiver 3. Instrument seals can be housed in relatively rigid housings for added strength.

Abstract: Devices, systems and methods are provided for enhancing mechanical strength of tissue, allowing direct and secure access to cardiac and vascular structures, either through tiny incisions or percutaneously. The method for accessing a cardiac chamber or a vascular conduit may include providing an access channel into tissue of the chamber or the conduit. The method may also include providing an energy-transducing element configured to provide heat within the access channel. The method may further include applying energy to the tissue or a tissue-stabilizing composition injected into, around, or adjacent to the tissue to mechanically enhance the access channel.